psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C263	R:R:C7	7.28	No	No	0	4	5
2	R:R:C7	R:R:K266	6.47	No	No	0	5	4
3	R:R:A267	R:R:W10	9.08	No	No	0	4	3
4	R:R:C270	R:R:W10	5.22	No	No	0	1	3
5	R:R:K266	R:R:L11	12.69	No	No	0	4	5
6	R:R:E14	R:R:K269	20.25	No	No	0	3	4
7	R:R:K18	R:R:Y79	7.17	No	No	0	2	4
8	R:R:K19	R:R:Y20	15.53	No	No	0	4	5
9	R:R:F25	R:R:Y21	8.25	No	Yes	5	4	5
10	R:R:L274	R:R:Y21	11.72	No	Yes	0	5	5
11	R:R:P277	R:R:Y21	6.95	No	Yes	5	5	5
12	R:R:L22	R:R:Y26	8.21	No	Yes	0	6	8
13	R:R:L22	R:R:Y79	11.72	No	No	0	6	4
14	R:R:I273	R:R:L22	4.28	No	No	0	4	6
15	R:R:E29	R:R:F25	8.16	No	No	0	7	4
16	R:R:F25	R:R:P277	14.45	No	No	5	4	5
17	R:R:L72	R:R:Y26	4.69	No	Yes	0	7	8
18	R:R:P277	R:R:Y26	6.95	No	Yes	0	5	8
19	R:R:F280	R:R:Y26	9.28	No	Yes	0	7	8
20	R:R:E29	R:R:L281	7.95	No	No	0	7	5
21	R:R:F30	R:R:M34	8.71	No	No	0	7	6
22	R:R:F30	R:R:P73	10.11	No	No	0	7	9
23	R:R:F38	R:R:M34	6.22	No	No	0	3	6
24	R:R:N37	R:R:S62	4.47	No	No	0	9	8
25	R:R:D65	R:R:N37	12.12	Yes	No	0	9	9
26	R:R:N37	R:R:P287	8.15	No	No	0	9	9
27	R:R:F38	R:R:L66	8.53	No	No	0	3	7
28	R:R:V40	R:R:Y290	21.45	No	Yes	3	9	9
29	R:R:F297	R:R:V40	5.24	Yes	No	3	8	9
30	R:R:F59	R:R:V41	6.55	Yes	No	0	6	7
31	R:R:F42	R:R:F46	9.65	No	No	0	4	4
32	R:R:M48	R:R:Y44	11.97	Yes	Yes	3	6	7
33	R:R:W51	R:R:Y44	5.79	Yes	Yes	3	6	7
34	R:R:N55	R:R:Y44	11.63	No	Yes	3	8	7
35	R:R:L58	R:R:Y44	4.69	No	Yes	3	8	7
36	R:R:F59	R:R:Y44	5.16	Yes	Yes	3	6	7
37	R:R:Y290	R:R:Y44	12.91	Yes	Yes	3	9	7
38	R:R:F297	R:R:Y44	8.25	Yes	Yes	3	8	7
39	R:R:F59	R:R:L45	4.87	Yes	No	0	6	4
40	R:R:M48	R:R:W51	4.65	Yes	Yes	3	6	6
41	R:R:D295	R:R:M48	4.16	No	Yes	0	4	6
42	R:R:F297	R:R:M48	4.98	Yes	Yes	3	8	6
43	R:R:N55	R:R:W51	7.91	No	Yes	3	8	6
44	R:R:F59	R:R:W51	12.03	Yes	Yes	3	6	6
45	R:R:N52	R:R:S54	4.47	No	No	0	7	7
46	R:R:N52	R:R:N55	13.62	No	No	0	7	8
47	R:R:N52	R:R:R125	14.46	No	Yes	0	7	4
48	R:R:D115	R:R:S53	8.83	No	No	0	8	6
49	R:R:D115	R:R:S54	5.89	No	No	0	8	7
50	R:R:R116	R:R:S54	6.59	No	No	0	9	7
51	R:R:A135	R:R:V56	5.09	No	No	0	7	6
52	R:R:F111	R:R:Y57	10.32	No	Yes	6	7	8
53	R:R:I112	R:R:Y57	4.84	No	Yes	0	9	8
54	R:R:I138	R:R:Y57	7.25	No	Yes	6	6	8
55	R:R:L58	R:R:Y290	11.72	No	Yes	3	8	9
56	R:R:F59	R:R:I63	6.28	Yes	No	0	6	6
57	R:R:F108	R:R:N60	13.29	Yes	No	2	7	9
58	R:R:N60	R:R:S139	10.43	No	No	0	9	8
59	R:R:N60	R:R:W143	4.52	No	Yes	2	9	9
60	R:R:L109	R:R:L61	4.15	No	No	0	8	9
61	R:R:L61	R:R:N286	13.73	No	Yes	0	9	9
62	R:R:S62	R:R:Y290	6.36	No	Yes	0	8	9
63	R:R:N101	R:R:S64	5.96	Yes	No	2	8	8
64	R:R:S64	R:R:T104	4.8	No	Yes	2	8	7
65	R:R:S64	R:R:W143	4.94	No	Yes	2	8	9
66	R:R:D65	R:R:N101	6.73	Yes	Yes	2	9	8
67	R:R:D65	R:R:S283	4.42	Yes	Yes	2	9	8
68	R:R:D65	R:R:N286	12.12	Yes	Yes	0	9	9
69	R:R:F68	R:R:L72	8.53	Yes	No	0	7	7
70	R:R:F68	R:R:L98	6.09	Yes	No	2	7	7
71	R:R:F68	R:R:N101	10.87	Yes	Yes	2	7	8
72	R:R:F280	R:R:F68	5.36	No	Yes	2	7	7
73	R:R:F68	R:R:S283	5.28	Yes	Yes	2	7	8
74	R:R:L69	R:R:S283	7.51	No	Yes	0	5	8
75	R:R:N94	R:R:T71	13.16	No	No	0	5	6
76	R:R:M74	R:R:W84	4.65	Yes	Yes	4	7	8
77	R:R:M74	R:R:Y86	19.16	Yes	No	4	7	7
78	R:R:L90	R:R:M74	8.48	No	Yes	0	6	7
79	R:R:M74	R:R:N94	7.01	Yes	No	0	7	5
80	R:R:S78	R:R:W84	6.18	No	Yes	0	5	8
81	R:R:N83	R:R:T85	4.39	No	No	0	4	3
82	R:R:W84	R:R:Y86	12.54	Yes	No	4	8	7
83	R:R:C91	R:R:W84	5.22	No	Yes	4	9	8
84	R:R:C168	R:R:W84	16.98	No	Yes	4	9	8
85	R:R:T85	R:R:Y86	7.49	No	No	0	3	7
86	R:R:C168	R:R:C91	7.28	No	No	4	9	9
87	R:R:I157	R:R:I92	4.42	No	No	7	4	7
88	R:R:I157	R:R:R95	5.01	No	No	0	4	6
89	R:R:A100	R:R:Y96	6.67	No	Yes	0	5	5
90	R:R:T147	R:R:Y96	9.99	No	Yes	0	4	5
91	R:R:H99	R:R:L98	7.71	No	No	0	5	7
92	R:R:F280	R:R:L98	8.53	No	No	2	7	7
93	R:R:H99	R:R:M153	13.13	No	No	0	5	3
94	R:R:N101	R:R:S105	4.47	Yes	No	0	8	9
95	R:R:N101	R:R:S283	4.47	Yes	Yes	2	8	8
96	R:R:F241	R:R:L102	8.53	Yes	No	0	8	7
97	R:R:L102	R:R:Y244	4.69	No	Yes	0	7	6
98	R:R:L187	R:R:Y103	10.55	Yes	Yes	1	5	7
99	R:R:G191	R:R:Y103	4.35	No	Yes	0	5	7
100	R:R:H245	R:R:Y103	7.62	Yes	Yes	1	8	7
101	R:R:R248	R:R:Y103	5.14	Yes	Yes	1	6	7
102	R:R:F108	R:R:T104	7.78	Yes	Yes	2	7	7
103	R:R:T104	R:R:W143	7.28	Yes	Yes	2	7	9
104	R:R:T104	R:R:V146	4.76	Yes	No	0	7	7
105	R:R:N282	R:R:S105	8.94	Yes	No	0	9	9
106	R:R:I106	R:R:P195	6.77	No	No	0	8	9
107	R:R:F237	R:R:I106	16.33	No	No	0	9	8
108	R:R:L107	R:R:V142	5.96	No	No	0	5	7
109	R:R:F108	R:R:V142	9.18	Yes	No	0	7	7
110	R:R:F108	R:R:W143	6.01	Yes	Yes	2	7	9
111	R:R:A233	R:R:L109	4.73	No	No	0	8	8
112	R:R:F289	R:R:L109	15.83	Yes	No	0	7	8
113	R:R:M199	R:R:T110	6.02	No	No	0	8	7
114	R:R:F111	R:R:I138	10.05	No	No	6	7	6
115	R:R:I112	R:R:L229	5.71	No	No	0	9	8
116	R:R:M199	R:R:S113	4.6	No	No	0	8	9
117	R:R:S113	R:R:V230	8.08	No	No	0	9	7
118	R:R:F202	R:R:I114	13.82	No	No	0	8	7
119	R:R:D115	R:R:R125	10.72	No	Yes	0	8	4
120	R:R:L119	R:R:R116	4.86	No	No	0	7	9
121	R:R:R116	R:R:V293	10.46	No	No	0	9	7
122	R:R:K121	R:R:Y117	14.33	No	Yes	0	8	8
123	R:R:F202	R:R:Y117	7.22	No	Yes	0	8	8
124	R:R:K205	R:R:Y117	9.55	No	Yes	0	4	8
125	R:R:M206	R:R:Y117	5.99	No	Yes	0	8	8
126	R:R:L118	R:R:Q130	5.32	No	Yes	0	5	6
127	R:R:L119	R:R:R125	8.5	No	Yes	0	7	4
128	R:R:M120	R:R:M206	10.11	Yes	No	0	8	8
129	R:R:F209	R:R:M120	8.71	No	Yes	0	4	8
130	R:R:L210	R:R:M120	5.65	No	Yes	0	8	8
131	R:R:F122	R:R:K121	11.17	Yes	No	0	6	8
132	R:R:F209	R:R:K121	7.44	No	No	0	4	8
133	R:R:F122	R:R:H127	14.71	Yes	No	8	6	5
134	R:R:F122	R:R:Q130	5.86	Yes	Yes	8	6	6
135	R:R:E126	R:R:F124	5.83	No	No	0	6	5
136	R:R:Q130	R:R:R125	9.35	Yes	Yes	0	6	4
137	R:R:H127	R:R:Q130	6.18	No	Yes	8	5	6
138	R:R:F134	R:R:L129	8.53	No	No	0	3	2
139	R:R:E133	R:R:K132	8.1	No	No	0	4	3
140	R:R:F134	R:R:I138	7.54	No	No	0	3	6
141	R:R:E149	R:R:L145	9.28	No	No	0	5	5
142	R:R:P152	R:R:Y183	12.52	No	Yes	0	8	6
143	R:R:M153	R:R:Y171	16.76	No	Yes	1	3	3
144	R:R:M153	R:R:Y183	9.58	No	Yes	1	3	6
145	R:R:F156	R:R:T155	7.78	No	No	0	4	5
146	R:R:F156	R:R:S180	9.25	No	No	0	4	4
147	R:R:F156	R:R:Y183	7.22	No	Yes	0	4	6
148	R:R:D170	R:R:Y272	10.34	No	Yes	1	5	5
149	R:R:D170	R:R:R276	14.29	No	No	1	5	5
150	R:R:S180	R:R:Y171	7.63	No	Yes	0	4	3
151	R:R:Y171	R:R:Y183	7.94	Yes	Yes	1	3	6
152	R:R:S184	R:R:Y171	6.36	No	Yes	1	5	3
153	R:R:R248	R:R:Y171	5.14	Yes	Yes	1	6	3
154	R:R:A172	R:R:Y272	5.34	No	Yes	0	5	5
155	R:R:R251	R:R:S173	5.27	Yes	No	0	4	4
156	R:R:N176	R:R:P177	6.52	No	No	0	2	1
157	R:R:N176	R:R:Y179	6.98	No	No	0	2	3
158	R:R:P177	R:R:R255	10.09	No	No	0	1	3
159	R:R:L256	R:R:P177	6.57	No	No	0	2	1
160	R:R:K178	R:R:Y179	10.75	No	No	0	1	3
161	R:R:I252	R:R:S180	6.19	No	No	0	5	4
162	R:R:L181	R:R:L185	5.54	No	No	0	3	4
163	R:R:L187	R:R:Y183	9.38	Yes	Yes	1	5	6
164	R:R:R248	R:R:S184	9.22	Yes	No	1	6	5
165	R:R:N249	R:R:S184	8.94	No	No	0	5	5
166	R:R:L185	R:R:N249	9.61	No	No	0	4	5
167	R:R:L187	R:R:R248	4.86	Yes	Yes	1	5	6
168	R:R:H245	R:R:T188	10.95	Yes	No	0	8	5
169	R:R:N249	R:R:T188	7.31	No	No	0	5	5
170	R:R:I194	R:R:L189	5.71	No	No	0	6	4
171	R:R:F192	R:R:L193	4.87	Yes	No	0	8	4
172	R:R:F192	R:R:L196	6.09	Yes	No	0	8	6
173	R:R:F192	R:R:F241	12.86	Yes	Yes	1	8	8
174	R:R:F192	R:R:H245	18.1	Yes	Yes	1	8	8
175	R:R:L196	R:R:S238	4.5	No	No	0	6	6
176	R:R:F201	R:R:F202	12.86	No	No	0	5	8
177	R:R:F201	R:R:K205	11.17	No	No	0	5	4
178	R:R:V207	R:R:Y203	6.31	No	No	0	6	8
179	R:R:V231	R:R:Y203	5.05	No	No	0	4	8
180	R:R:V208	R:R:Y204	7.57	No	No	0	3	3
181	R:R:F209	R:R:R213	17.1	No	No	0	4	5
182	R:R:L210	R:R:L227	4.15	No	No	0	8	6
183	R:R:K225	R:R:R228	16.09	No	No	0	7	6
184	R:R:L292	R:R:R228	7.29	No	No	0	7	6
185	R:R:F289	R:R:L229	4.87	Yes	No	0	7	8
186	R:R:L229	R:R:L292	4.15	No	No	0	8	7
187	R:R:I236	R:R:L232	7.14	No	No	0	6	6
188	R:R:F289	R:R:L232	6.09	Yes	No	0	7	6
189	R:R:F237	R:R:F241	9.65	No	Yes	1	9	8
190	R:R:F237	R:R:N282	4.83	No	Yes	1	9	9
191	R:R:F241	R:R:H245	6.79	Yes	Yes	1	8	8
192	R:R:F241	R:R:N282	4.83	Yes	Yes	1	8	9
193	R:R:H245	R:R:Y244	10.89	Yes	Yes	1	8	6
194	R:R:R248	R:R:Y244	10.29	Yes	Yes	1	6	6
195	R:R:Y244	R:R:Y272	5.96	Yes	Yes	1	6	5
196	R:R:A279	R:R:Y244	5.34	No	Yes	0	8	6
197	R:R:H245	R:R:R248	5.64	Yes	Yes	1	8	6
198	R:R:M247	R:R:T275	6.02	No	No	0	5	7
199	R:R:R248	R:R:Y272	8.23	Yes	Yes	1	6	5
200	R:R:I268	R:R:V250	4.61	No	No	0	5	5
201	R:R:R251	R:R:R255	5.33	Yes	No	0	4	3
202	R:R:K269	R:R:R251	13.61	No	Yes	0	4	4
203	R:R:R251	R:R:Y272	7.2	Yes	Yes	0	4	5
204	R:R:S254	R:R:W259	7.41	No	Yes	0	3	1
205	R:R:I268	R:R:S254	7.74	No	No	0	5	3
206	R:R:P260	R:R:W259	14.86	No	Yes	0	1	1
207	R:R:Q265	R:R:W259	5.48	No	Yes	0	3	1
208	R:R:R276	R:R:Y272	14.4	No	Yes	1	5	5
209	R:R:I273	R:R:R276	5.01	No	No	0	4	5
210	R:R:N282	R:R:N286	6.81	Yes	Yes	0	9	9
211	R:R:N286	R:R:P287	6.52	Yes	No	0	9	9
212	R:R:F297	R:R:Y290	7.22	Yes	Yes	3	8	9
213	R:R:F291	R:R:F297	6.43	No	Yes	0	7	8
214	R:R:D295	R:R:V293	4.38	No	No	0	4	7
215	R:R:D299	R:R:H296	8.82	No	No	0	5	6
216	R:R:F297	R:R:L301	10.96	Yes	No	0	8	7
217	R:R:F302	R:R:R298	5.34	No	No	0	1	8
218	R:R:R306	R:R:S303	5.27	No	No	0	7	4
219	R:R:K304	R:R:Y308	19.11	No	No	0	5	6
220	R:R:F309	R:R:K310	7.44	No	No	0	3	6
221	R:R:K310	R:R:T313	4.5	No	No	0	6	7
222	R:R:F46	R:R:Y308	4.13	No	No	0	4	6
223	R:R:A135	R:R:Y57	4	No	Yes	0	7	8
224	R:R:C263	R:R:W10	3.92	No	No	0	4	3
225	R:R:F192	R:R:T242	3.89	Yes	No	0	8	6
226	R:R:V150	R:R:Y96	3.79	No	Yes	0	6	5
227	R:R:F289	R:R:I288	3.77	Yes	No	0	7	6
228	R:R:I76	R:R:R77	3.76	Yes	No	0	7	4
229	R:R:T275	R:R:Y244	3.75	No	Yes	0	7	6
230	R:R:F30	R:R:L72	3.65	No	No	0	7	7
231	R:R:G36	R:R:T39	3.64	No	No	0	7	5
232	R:R:G27	R:R:I76	3.53	No	Yes	0	5	7
233	R:R:L17	R:R:Y21	3.52	No	Yes	0	4	5
234	R:R:L75	R:R:Y26	3.52	No	Yes	0	6	8
235	R:R:L75	R:R:Y79	3.52	No	No	0	6	4
236	R:R:P243	R:R:T242	3.5	No	No	0	9	6
237	R:R:P243	R:R:T275	3.5	No	No	0	9	7
238	R:R:C7	R:R:S6	3.44	No	No	0	5	7
239	R:R:G33	R:R:L69	3.42	No	No	0	8	5
240	R:R:C200	R:R:V234	3.42	No	No	0	5	8
241	R:R:A284	R:R:V32	3.39	No	No	0	8	5
242	R:R:I194	R:R:P195	3.39	No	No	0	6	9
243	R:R:M120	R:R:P226	3.35	Yes	No	0	8	8
244	R:R:L278	R:R:P243	3.28	No	No	0	8	9
245	R:R:C47	R:R:K304	3.23	No	No	0	5	5
246	R:R:S173	R:R:V169	3.23	No	No	0	4	4
247	R:R:S174	R:R:V169	3.23	No	No	0	1	4
248	R:R:F38	R:R:F42	3.22	No	No	0	3	4
249	R:R:C270	R:R:L17	3.17	No	No	0	1	4
250	R:R:T110	R:R:V198	3.17	No	No	0	7	6
251	R:R:A253	R:R:L181	3.15	No	No	0	4	3
252	R:R:I136	R:R:V56	3.07	No	No	0	3	6
253	R:R:I236	R:R:V285	3.07	No	No	0	6	5
254	R:R:M206	R:R:V230	3.04	No	No	0	8	7
255	R:R:K211	R:R:V207	3.04	No	No	0	5	6
256	R:R:I246	R:R:T242	3.04	No	No	0	6	6
257	R:R:M247	R:R:V250	3.04	No	No	0	5	5
258	R:R:F297	R:R:G43	3.01	Yes	No	0	8	7
259	R:R:L90	R:R:S93	3	No	No	0	6	5
260	R:R:L227	R:R:V207	2.98	No	No	0	6	6
261	R:R:M300	R:R:M48	2.89	No	Yes	0	4	6
262	R:R:F124	R:R:P123	2.89	No	No	0	5	8
263	R:R:I236	R:R:L240	2.85	No	No	0	6	9
264	R:R:L271	R:R:M247	2.83	No	No	0	5	5
265	R:R:G87	R:R:W84	2.81	No	Yes	0	8	8
266	R:R:C91	R:R:R95	2.79	No	No	0	9	6
267	R:R:H99	R:R:V150	2.77	No	No	0	5	6
268	R:R:E133	R:R:K131	2.7	No	No	0	4	7
269	R:R:E149	R:R:L187	2.65	No	Yes	0	5	5
270	R:R:E149	R:R:L190	2.65	No	No	0	5	4
271	R:R:E8	R:R:N9	2.63	No	No	0	4	8
272	R:R:F68	R:R:T71	2.59	Yes	No	0	7	6
273	R:R:V97	R:R:Y96	2.52	No	Yes	0	6	5
274	R:R:S167	R:R:W84	2.47	No	Yes	0	4	8
275	R:R:S264	R:R:W259	2.47	No	Yes	0	1	1
276	R:R:I76	R:R:Y26	2.42	Yes	Yes	0	7	8
277	R:R:D299	R:R:R298	2.38	No	No	0	5	8
278	R:R:F291	R:R:R298	2.14	No	No	0	7	8
279	R:R:A284	R:R:G33	1.95	No	No	0	8	8
280	R:R:G175	R:R:S174	1.86	No	No	0	2	1
281	R:R:G82	R:R:T81	1.82	No	No	0	4	4
282	R:R:G294	R:R:K225	1.74	No	No	0	8	7
283	R:R:A80	R:R:S23	1.71	No	No	0	4	5
284	R:R:G36	R:R:L35	1.71	No	No	0	7	5
285	R:R:L151	R:R:P152	1.64	No	No	0	4	8
286	R:R:C186	R:R:I182	1.64	No	No	0	3	3
287	R:R:C70	R:R:M34	1.62	No	No	0	5	6
288	R:R:S238	R:R:V234	1.62	No	No	0	6	8
289	R:R:V231	R:R:V235	1.6	No	No	0	4	5
290	R:R:S314	R:R:T313	1.6	No	No	0	7	7
291	R:R:C270	R:R:L13	1.59	No	No	0	1	5
292	R:R:I76	R:R:S23	1.55	Yes	No	0	7	5
293	R:R:I28	R:R:V32	1.54	No	No	0	5	5
294	R:R:K132	R:R:V56	1.52	No	No	0	3	6
295	R:R:K212	R:R:V208	1.52	No	No	0	5	3
296	R:R:L256	R:R:S258	1.5	No	No	0	2	1
297	R:R:L148	R:R:V144	1.49	No	No	0	4	4
298	R:R:L240	R:R:V239	1.49	No	No	0	9	6
299	R:R:L301	R:R:T39	1.47	No	No	0	7	5
300	R:R:L312	R:R:T313	1.47	No	No	0	5	7
301	R:R:N83	R:R:T81	1.46	No	No	0	4	4
302	R:R:F122	R:R:P123	1.44	Yes	No	0	6	8
303	R:R:I31	R:R:L35	1.43	No	No	0	5	5
304	R:R:I92	R:R:L154	1.43	No	No	7	7	4
305	R:R:I157	R:R:L154	1.43	No	No	7	4	4
306	R:R:K18	R:R:N15	1.4	No	No	0	2	4
307	R:R:L148	R:R:L151	1.38	No	No	0	4	4
308	R:R:L227	R:R:N224	1.37	No	No	0	6	5
309	R:R:F134	R:R:I128	1.26	No	No	0	3	3
310	R:R:F315	R:R:L317	1.22	No	No	0	7	5
311	R:R:K205	R:R:Y204	1.19	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y21	7.61	4	5	5
2	R:R:Y26	5.845	6	0	8
3	R:R:Y44	8.62857	7	3	7
4	R:R:M48	5.73	5	3	6
5	R:R:W51	7.595	4	3	6
6	R:R:Y57	6.6025	4	6	8
7	R:R:F59	6.978	5	3	6
8	R:R:D65	8.8475	4	2	9
9	R:R:F68	6.45333	6	2	7
10	R:R:M74	9.825	4	4	7
11	R:R:I76	2.815	4	0	7
12	R:R:W84	7.26429	7	4	8
13	R:R:Y96	5.7425	4	0	5
14	R:R:N101	6.5	5	2	8
15	R:R:Y103	6.915	4	1	7
16	R:R:T104	6.155	4	2	7
17	R:R:F108	9.065	4	2	7
18	R:R:Y117	9.2725	4	0	8
19	R:R:M120	6.955	4	0	8
20	R:R:F122	8.295	4	8	6
21	R:R:R125	10.7575	4	0	4
22	R:R:Q130	6.6775	4	8	6
23	R:R:W143	5.6875	4	2	9
24	R:R:Y171	8.766	5	1	3
25	R:R:Y183	9.328	5	1	6
26	R:R:L187	6.86	4	1	5
27	R:R:F192	9.162	5	1	8
28	R:R:F241	8.532	5	1	8
29	R:R:Y244	6.82	6	1	6
30	R:R:H245	9.99833	6	1	8
31	R:R:R248	6.93143	7	1	6
32	R:R:R251	7.8525	4	0	4
33	R:R:W259	7.555	4	0	1
34	R:R:Y272	8.57833	6	1	5
35	R:R:N282	6.3525	4	1	9
36	R:R:S283	5.42	4	2	8
37	R:R:N286	9.795	4	0	9
38	R:R:F289	7.64	4	0	7
39	R:R:Y290	11.932	5	3	9
40	R:R:F297	6.58429	7	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C270	R:R:W10	11.3491	5.22	No	No	0	1	3
2	R:R:C270	R:R:L17	14.5496	3.17	No	No	0	1	4
3	R:R:L17	R:R:Y21	16.1427	3.52	No	Yes	0	4	5
4	R:R:P277	R:R:Y21	19.2293	6.95	No	Yes	5	5	5
5	R:R:P277	R:R:Y26	25.6019	6.95	No	Yes	0	5	8
6	R:R:L22	R:R:Y26	14.7942	8.21	No	Yes	0	6	8
7	R:R:I273	R:R:L22	10.4041	4.28	No	No	0	4	6
8	R:R:R251	R:R:Y272	28.6671	7.2	Yes	Yes	0	4	5
9	R:R:L72	R:R:Y26	23.617	4.69	No	Yes	0	7	8
10	R:R:F280	R:R:Y26	23.6383	9.28	No	Yes	0	7	8
11	R:R:F30	R:R:L72	10.0123	3.65	No	No	0	7	7
12	R:R:F68	R:R:L72	30.7113	8.53	Yes	No	0	7	7
13	R:R:F68	R:R:N101	38.3993	10.87	Yes	Yes	2	7	8
14	R:R:D65	R:R:N101	32.993	6.73	Yes	Yes	2	9	8
15	R:R:D65	R:R:N37	74.4314	12.12	Yes	No	0	9	9
16	R:R:F280	R:R:F68	22.4108	5.36	No	Yes	2	7	7
17	R:R:F68	R:R:S283	31.9175	5.28	Yes	Yes	2	7	8
18	R:R:D65	R:R:S283	32.3876	4.42	Yes	Yes	2	9	8
19	R:R:N37	R:R:S62	100	4.47	No	No	0	9	8
20	R:R:N37	R:R:P287	27.7625	8.15	No	No	0	9	9
21	R:R:D65	R:R:N286	44.9641	12.12	Yes	Yes	0	9	9
22	R:R:N286	R:R:P287	27.9904	6.52	Yes	No	0	9	9
23	R:R:S62	R:R:Y290	98.8817	6.36	No	Yes	0	8	9
24	R:R:F297	R:R:Y290	22.1853	7.22	Yes	Yes	3	8	9
25	R:R:Y290	R:R:Y44	73.1113	12.91	Yes	Yes	3	9	7
26	R:R:N55	R:R:Y44	60.9692	11.63	No	Yes	3	8	7
27	R:R:N52	R:R:N55	60.4397	13.62	No	No	0	7	8
28	R:R:N52	R:R:R125	53.7799	14.46	No	Yes	0	7	4
29	R:R:I112	R:R:Y57	15.5824	4.84	No	Yes	0	9	8
30	R:R:I112	R:R:L229	16.8503	5.71	No	No	0	9	8
31	R:R:F289	R:R:L229	23.1184	4.87	Yes	No	0	7	8
32	R:R:F289	R:R:L109	31.6943	15.83	Yes	No	0	7	8
33	R:R:L109	R:R:L61	34.1018	4.15	No	No	0	8	9
34	R:R:L61	R:R:N286	35.2984	13.73	No	Yes	0	9	9
35	R:R:N101	R:R:S64	10.0266	5.96	Yes	No	2	8	8
36	R:R:F68	R:R:T71	21.7365	2.59	Yes	No	0	7	6
37	R:R:N94	R:R:T71	20.6942	13.16	No	No	0	5	6
38	R:R:M74	R:R:N94	19.6472	7.01	Yes	No	0	7	5
39	R:R:M74	R:R:W84	10.9811	4.65	Yes	Yes	4	7	8
40	R:R:H99	R:R:L98	14.59	7.71	No	No	0	5	7
41	R:R:H99	R:R:M153	11.2019	13.13	No	No	0	5	3
42	R:R:N101	R:R:S105	10.2593	4.47	Yes	No	0	8	9
43	R:R:N282	R:R:S105	10.1667	8.94	Yes	No	0	9	9
44	R:R:F241	R:R:N282	61.2304	4.83	Yes	Yes	1	8	9
45	R:R:Y244	R:R:Y272	22.3539	5.96	Yes	Yes	1	6	5
46	R:R:L102	R:R:Y244	16.5582	4.69	No	Yes	0	7	6
47	R:R:R248	R:R:Y272	14.381	8.23	Yes	Yes	1	6	5
48	R:R:H245	R:R:Y244	17.9021	10.89	Yes	Yes	1	8	6
49	R:R:H245	R:R:R248	17.356	5.64	Yes	Yes	1	8	6
50	R:R:Q130	R:R:R125	48.9434	9.35	Yes	Yes	0	6	4
51	R:R:F122	R:R:Q130	44.9	5.86	Yes	Yes	8	6	6
52	R:R:F122	R:R:K121	39.6196	11.17	Yes	No	0	6	8
53	R:R:K121	R:R:Y117	21.3021	14.33	No	Yes	0	8	8
54	R:R:F209	R:R:K121	17.0497	7.44	No	No	0	4	8
55	R:R:F209	R:R:M120	14.2481	8.71	No	Yes	0	4	8
56	R:R:L210	R:R:M120	11.6981	5.65	No	Yes	0	8	8
57	R:R:R251	R:R:R255	14.457	5.33	Yes	No	0	4	3
58	R:R:P177	R:R:R255	12.4056	10.09	No	No	0	1	3
59	R:R:L210	R:R:L227	10.2521	4.15	No	No	0	8	6
60	R:R:T275	R:R:Y244	15.4779	3.75	No	Yes	0	7	6
61	R:R:M247	R:R:T275	13.4812	6.02	No	No	0	5	7
62	R:R:M247	R:R:V250	10.5181	3.04	No	No	0	5	5
63	R:R:F241	R:R:L102	16.9666	8.53	Yes	No	0	8	7
64	R:R:N282	R:R:N286	55.3493	6.81	Yes	Yes	0	9	9
65	R:R:F241	R:R:H245	38.9026	6.79	Yes	Yes	1	8	8
66	R:R:F68	R:R:L98	13.3197	6.09	Yes	No	2	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6IBB

PDB Summary
PDB	6IBB
Class	A
SubFamily	Alicarboxylic acid
Type	Succinate
SubType	Succinate
Species	Rattus norvegicus
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.12
Date	2019-08-14
D.O.I.	10.1038/s41586-019-1663-8

Net Summary
I_min	4.14
Number of Linked Nodes	274
Number of Links	311
Number of Hubs	40
Number of Links mediated by Hubs	150
Number of Communities	8
Number of Nodes involved in Communities	53
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	78273
Length Of Smallest Path	3
Average Path Length	14.8158
Length of Longest Path	32
Minimum Path Strength	1.435
Average Path Strength	7.60774
Maximum Path Strength	17.18
Minimum Path Correlation	0.7
Average Path Correlation	0.941104
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	55.0503
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.247
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q6IYF9
Sequence	>6IBB_Chain_R S C E N W L A L E N I L K K Y Y L S A F Y G I E F I V G M L G N F T V V F G Y L F C M K N W N S S N V Y L F N L S I S D L A F L C T L P M L I R S Y A T G N W T Y G D V L C I S N R Y V L H A N L Y T S I L F L T F I S I D R Y L L M K F P F R E H I L Q K K E F A I L I S L A V W V L V T L E V L P M L T F I T S S C V D Y A S S G N P K Y S L I Y S L C L T L L G F L I P L S V M C F F Y Y K M V V F L K K R N K P L R L V V L A V V I F S V L F T P Y H I M R N V R I A S R L D S W P Q G C S Q K A I K C L Y I L T R P L A F L N S A V N P I F Y F L V G D H F R D M L F S K L R Q Y F K S L T S F R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6IBB	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	-	-	-	2.12	2019-08-14	10.1038/s41586-019-1663-8
	6RNK	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	NF-56-EJ40	-	-	1.94	2019-08-14	10.1038/s41586-019-1663-8
	6Z10	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	PubChem 154585554	-	-	2.27	2020-09-16	10.1021/acs.jmedchem.0c01020

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6IBB.zip

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