psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N13	R:R:W14	6.78	No	No	0	6	5
2	R:R:E18	R:R:W14	11.99	Yes	No	0	5	5
3	R:R:V272	R:R:W14	13.48	No	No	0	3	5
4	R:R:E18	R:R:L21	5.3	Yes	No	0	5	4
5	R:R:E18	R:R:V271	4.28	Yes	No	0	5	2
6	R:R:E18	R:R:S275	11.5	Yes	No	0	5	1
7	R:R:E22	R:R:Y83	8.98	No	Yes	0	5	5
8	R:R:K23	R:R:Y24	21.5	No	No	0	4	3
9	R:R:F29	R:R:Y25	21.66	No	No	1	5	4
10	R:R:V279	R:R:Y25	8.83	No	No	0	5	4
11	R:R:P282	R:R:Y25	5.56	No	No	1	5	4
12	R:R:L26	R:R:Y30	8.21	No	Yes	0	6	8
13	R:R:L26	R:R:Y83	5.86	No	Yes	0	6	5
14	R:R:I278	R:R:L26	5.71	No	No	0	4	6
15	R:R:F29	R:R:P282	10.11	No	No	1	5	5
16	R:R:L76	R:R:Y30	5.86	No	Yes	0	8	8
17	R:R:R281	R:R:Y30	5.14	Yes	Yes	1	6	8
18	R:R:P282	R:R:Y30	11.13	No	Yes	1	5	8
19	R:R:F285	R:R:Y30	9.28	Yes	Yes	1	7	8
20	L:L:?1	R:R:Y30	11.06	Yes	Yes	1	0	8
21	R:R:E33	R:R:F285	4.66	No	Yes	0	7	7
22	R:R:F34	R:R:V38	5.24	No	No	0	7	6
23	R:R:F34	R:R:P77	11.56	No	No	0	7	8
24	R:R:G37	R:R:V289	5.52	No	No	0	8	8
25	R:R:G40	R:R:P292	4.06	No	No	0	8	9
26	R:R:D69	R:R:N41	6.73	Yes	Yes	0	9	9
27	R:R:L70	R:R:N41	6.87	No	Yes	0	8	9
28	R:R:L73	R:R:N41	4.12	Yes	Yes	0	6	9
29	R:R:N41	R:R:P292	9.77	Yes	No	0	9	9
30	R:R:P292	R:R:V44	5.3	No	No	0	9	9
31	R:R:F296	R:R:V44	7.87	Yes	No	0	6	9
32	R:R:Q309	R:R:Y46	7.89	No	No	0	5	4
33	R:R:L62	R:R:Y48	7.03	No	Yes	0	8	7
34	R:R:F63	R:R:Y48	6.19	No	Yes	0	6	7
35	R:R:S66	R:R:Y48	5.09	No	Yes	0	9	7
36	R:R:F296	R:R:Y48	11.35	Yes	Yes	0	6	7
37	R:R:F63	R:R:W55	7.02	No	No	0	6	6
38	R:R:N56	R:R:N59	9.54	No	No	0	7	7
39	R:R:N56	R:R:R129	14.46	No	No	0	7	5
40	R:R:D119	R:R:S57	7.36	No	No	0	8	6
41	R:R:D119	R:R:S58	4.42	No	No	0	8	8
42	R:R:I60	R:R:N64	4.25	Yes	No	0	7	9
43	R:R:A139	R:R:I60	4.87	No	Yes	0	7	7
44	R:R:I140	R:R:I60	5.89	No	Yes	0	4	7
45	R:R:F115	R:R:Y61	5.16	Yes	No	5	6	7
46	R:R:D119	R:R:Y61	5.75	No	No	0	8	7
47	R:R:I142	R:R:Y61	7.25	No	No	5	5	7
48	R:R:F63	R:R:V67	6.55	No	No	0	6	7
49	R:R:F112	R:R:N64	13.29	Yes	No	2	8	9
50	R:R:N64	R:R:S143	10.43	No	No	2	9	7
51	R:R:L113	R:R:L65	6.92	No	No	6	8	9
52	R:R:I116	R:R:L65	4.28	No	No	0	9	9
53	R:R:L65	R:R:N291	6.87	No	Yes	6	9	9
54	R:R:S68	R:R:T108	6.4	No	No	2	8	7
55	R:R:S109	R:R:S68	4.89	No	No	0	9	8
56	R:R:S68	R:R:W147	6.18	No	Yes	2	8	9
57	R:R:D69	R:R:S109	5.89	Yes	No	0	9	9
58	R:R:D69	R:R:S288	8.83	Yes	No	0	9	9
59	R:R:D69	R:R:N291	9.42	Yes	Yes	0	9	9
60	R:R:A71	R:R:N105	4.69	No	No	0	6	8
61	R:R:F72	R:R:L102	9.74	Yes	Yes	1	7	7
62	R:R:F72	R:R:L106	4.87	Yes	No	0	7	8
63	R:R:F285	R:R:F72	13.93	Yes	Yes	1	7	7
64	R:R:F72	R:R:S288	9.25	Yes	No	0	7	9
65	R:R:L73	R:R:L76	4.15	Yes	No	0	6	8
66	R:R:L73	R:R:S288	4.5	Yes	No	0	6	9
67	R:R:N98	R:R:T75	10.24	No	No	0	4	6
68	R:R:L102	R:R:T75	7.37	Yes	No	0	7	6
69	R:R:M78	R:R:W88	6.98	No	Yes	0	7	8
70	R:R:M78	R:R:Y90	8.38	No	Yes	0	7	7
71	R:R:M78	R:R:N98	15.43	No	No	0	7	4
72	R:R:L79	R:R:Y83	4.69	No	Yes	1	6	5
73	R:R:L79	R:R:N98	4.12	No	No	0	6	4
74	L:L:?1	R:R:L79	6.53	Yes	No	1	0	6
75	R:R:N85	R:R:R81	4.82	No	No	3	3	5
76	R:R:I89	R:R:R81	8.77	No	No	3	3	5
77	R:R:R81	R:R:Y90	16.46	No	Yes	3	5	7
78	R:R:S82	R:R:W88	8.65	No	Yes	0	5	8
79	R:R:D174	R:R:Y83	5.75	Yes	Yes	1	5	5
80	L:L:?1	R:R:Y83	6.63	Yes	Yes	1	0	5
81	R:R:I89	R:R:N85	5.66	No	No	3	3	3
82	R:R:C95	R:R:W88	7.84	No	Yes	0	9	8
83	R:R:C172	R:R:W88	7.84	No	Yes	0	9	8
84	R:R:I89	R:R:Y90	6.04	No	Yes	3	3	7
85	R:R:L94	R:R:Y90	5.86	No	Yes	0	6	7
86	R:R:I161	R:R:I96	5.89	No	No	0	4	7
87	R:R:I161	R:R:R99	7.52	No	No	0	4	6
88	R:R:D174	R:R:R99	5.96	Yes	No	1	5	6
89	L:L:?1	R:R:R99	5.73	Yes	No	1	0	6
90	R:R:T151	R:R:Y100	4.99	No	Yes	0	4	6
91	R:R:L154	R:R:Y100	4.69	Yes	Yes	0	7	6
92	R:R:L158	R:R:Y100	4.69	No	Yes	0	4	6
93	R:R:F285	R:R:L102	4.87	Yes	Yes	1	7	7
94	L:L:?1	R:R:L102	5.22	Yes	Yes	1	0	7
95	R:R:F175	R:R:H103	9.05	Yes	No	0	4	5
96	L:L:?1	R:R:H103	7.28	Yes	No	0	0	5
97	R:R:N105	R:R:W147	5.65	No	Yes	0	8	9
98	R:R:L106	R:R:Y107	7.03	No	Yes	0	8	7
99	R:R:L191	R:R:Y107	11.72	No	Yes	0	5	7
100	R:R:H249	R:R:Y107	7.62	Yes	Yes	1	8	7
101	R:R:R252	R:R:Y107	6.17	Yes	Yes	1	6	7
102	R:R:T108	R:R:W147	12.13	No	Yes	2	7	9
103	R:R:T108	R:R:V150	7.93	No	No	0	7	8
104	R:R:F241	R:R:I110	6.28	Yes	No	1	9	8
105	R:R:F245	R:R:I110	10.05	Yes	No	1	8	8
106	R:R:I146	R:R:L111	5.71	No	No	0	7	6
107	R:R:F112	R:R:S143	5.28	Yes	No	2	8	7
108	R:R:F112	R:R:I146	12.56	Yes	No	0	8	7
109	R:R:F112	R:R:W147	5.01	Yes	Yes	2	8	9
110	R:R:L113	R:R:N291	5.49	No	Yes	6	8	9
111	R:R:L113	R:R:Y295	4.69	No	No	0	8	9
112	R:R:P199	R:R:T114	5.25	Yes	No	0	8	7
113	R:R:F115	R:R:I142	10.05	Yes	No	5	6	5
114	R:R:F115	R:R:I146	7.54	Yes	No	0	6	7
115	R:R:I116	R:R:R120	5.01	No	No	0	9	9
116	R:R:M203	R:R:S117	6.13	No	No	1	8	9
117	R:R:S117	R:R:Y207	8.9	No	Yes	1	9	9
118	R:R:F206	R:R:I118	7.54	No	No	0	8	6
119	R:R:R120	R:R:Y207	8.23	No	Yes	0	9	9
120	R:R:R120	R:R:Y295	6.17	No	No	0	9	9
121	R:R:K125	R:R:Y121	8.36	No	Yes	0	7	8
122	R:R:F206	R:R:Y121	10.32	No	Yes	0	8	8
123	R:R:K209	R:R:Y121	5.97	No	Yes	0	4	8
124	R:R:I210	R:R:Y121	4.84	No	Yes	0	8	8
125	R:R:L122	R:R:Q134	6.65	No	Yes	0	5	7
126	R:R:I123	R:R:R129	8.77	No	No	4	8	5
127	R:R:I123	R:R:Q134	4.12	No	Yes	4	8	7
128	R:R:F213	R:R:I124	15.07	No	No	0	5	8
129	R:R:K125	R:R:Y126	17.91	No	Yes	0	7	6
130	R:R:H131	R:R:Y126	10.89	No	Yes	0	4	6
131	R:R:Q134	R:R:Y126	4.51	Yes	Yes	0	7	6
132	R:R:F128	R:R:P127	4.33	No	No	0	5	8
133	R:R:E130	R:R:F128	11.66	No	No	0	5	5
134	R:R:Q134	R:R:R129	7.01	Yes	No	4	7	5
135	R:R:H131	R:R:L133	7.71	No	No	0	4	3
136	R:R:F138	R:R:K135	7.44	No	No	0	4	6
137	R:R:E153	R:R:V150	4.28	No	No	0	5	8
138	R:R:I157	R:R:L154	4.28	Yes	Yes	1	4	7
139	R:R:L154	R:R:Y187	4.69	Yes	Yes	1	7	5
140	R:R:P156	R:R:Y187	12.52	No	Yes	0	8	5
141	R:R:I157	R:R:I161	4.42	Yes	No	0	4	4
142	R:R:F175	R:R:I157	11.3	Yes	Yes	1	4	4
143	R:R:I157	R:R:Y187	6.04	Yes	Yes	1	4	5
144	R:R:P159	R:R:Y183	5.56	No	No	0	4	2
145	R:R:L160	R:R:Y183	8.21	No	No	0	5	2
146	R:R:L160	R:R:N184	5.49	No	No	0	5	3
147	R:R:N173	R:R:T171	7.31	No	No	0	4	3
148	R:R:N173	R:R:S177	4.47	No	No	0	4	4
149	R:R:D174	R:R:R281	8.34	Yes	Yes	1	5	6
150	L:L:?1	R:R:D174	15.36	Yes	Yes	1	0	5
151	R:R:F175	R:R:N184	4.83	Yes	No	0	4	3
152	R:R:F175	R:R:Y187	4.13	Yes	Yes	1	4	5
153	R:R:F175	R:R:R252	5.34	Yes	Yes	1	4	6
154	R:R:A176	R:R:Y277	5.34	No	Yes	0	6	5
155	R:R:R255	R:R:S177	5.27	No	No	0	5	4
156	R:R:D180	R:R:P181	6.44	No	No	0	3	1
157	R:R:D180	R:R:N182	12.12	No	No	0	3	1
158	R:R:P181	R:R:R259	7.21	No	No	0	1	3
159	R:R:L260	R:R:P181	4.93	No	No	0	1	1
160	R:R:L260	R:R:N182	4.12	No	No	0	1	1
161	R:R:I256	R:R:N184	14.16	No	No	0	5	3
162	R:R:I256	R:R:L185	5.71	No	No	0	5	4
163	R:R:L191	R:R:Y187	8.21	No	Yes	0	5	5
164	R:R:R252	R:R:S188	7.91	Yes	No	0	6	5
165	R:R:N253	R:R:S188	5.96	No	No	0	6	5
166	R:R:M189	R:R:N253	9.82	No	No	0	5	6
167	R:R:H249	R:R:T192	9.58	Yes	No	0	8	6
168	R:R:N253	R:R:T192	7.31	No	No	0	6	6
169	R:R:G195	R:R:P199	4.06	No	Yes	0	6	8
170	R:R:F196	R:R:L197	4.87	Yes	No	0	8	4
171	R:R:F196	R:R:L200	4.87	Yes	No	1	8	6
172	R:R:F196	R:R:F241	5.36	Yes	Yes	1	8	9
173	R:R:F196	R:R:F245	5.36	Yes	Yes	1	8	8
174	R:R:F196	R:R:T246	9.08	Yes	Yes	0	8	5
175	R:R:F196	R:R:H249	19.23	Yes	Yes	1	8	8
176	R:R:F241	R:R:L200	4.87	Yes	No	1	9	6
177	R:R:M203	R:R:Y207	4.79	No	Yes	1	8	9
178	R:R:F241	R:R:M203	9.95	Yes	No	1	9	8
179	R:R:F205	R:R:F206	9.65	No	No	0	4	8
180	R:R:F205	R:R:K209	8.69	No	No	0	4	4
181	R:R:V234	R:R:Y207	8.83	No	Yes	0	8	9
182	R:R:V238	R:R:Y207	5.05	No	Yes	0	8	9
183	R:R:L212	R:R:Y208	16.41	No	No	0	3	3
184	R:R:F213	R:R:R217	9.62	No	No	0	5	5
185	R:R:L214	R:R:L227	4.15	No	No	0	7	6
186	R:R:K215	R:R:L231	4.23	No	No	0	4	6
187	R:R:Q220	R:R:R217	8.18	No	No	0	2	5
188	R:R:N218	R:R:P226	4.89	No	Yes	0	4	5
189	R:R:P226	R:R:R219	12.97	Yes	No	0	5	4
190	R:R:E228	R:R:P226	9.43	No	Yes	0	5	5
191	R:R:K229	R:R:L233	4.23	No	No	0	7	8
192	R:R:L233	R:R:L298	4.15	No	No	0	8	6
193	R:R:M236	R:R:V239	7.61	No	No	0	5	5
194	R:R:I240	R:R:I290	4.42	No	No	0	7	6
195	R:R:F294	R:R:I240	5.02	Yes	No	0	7	7
196	R:R:F241	R:R:F245	11.79	Yes	Yes	1	9	8
197	R:R:L244	R:R:N287	6.87	No	No	0	9	9
198	R:R:F245	R:R:N287	13.29	Yes	No	0	8	9
199	R:R:H249	R:R:Y248	6.53	Yes	Yes	1	8	7
200	R:R:R252	R:R:Y248	12.35	Yes	Yes	1	6	7
201	R:R:Y248	R:R:Y277	10.92	Yes	Yes	1	7	5
202	R:R:R281	R:R:Y248	4.12	Yes	Yes	1	6	7
203	R:R:A284	R:R:Y248	6.67	No	Yes	0	8	7
204	R:R:H249	R:R:R252	10.16	Yes	Yes	1	8	6
205	R:R:M251	R:R:V254	4.56	No	No	0	4	5
206	R:R:M251	R:R:T280	9.03	No	No	0	4	7
207	R:R:R252	R:R:Y277	8.23	Yes	Yes	1	6	5
208	R:R:N274	R:R:R255	12.05	No	No	0	3	5
209	R:R:F276	R:R:V272	5.24	No	No	0	5	3
210	R:R:I278	R:R:N274	7.08	No	No	0	4	3
211	R:R:R281	R:R:Y277	22.64	Yes	Yes	1	6	5
212	R:R:F285	R:R:R281	4.28	Yes	Yes	1	7	6
213	L:L:?1	R:R:R281	28.65	Yes	Yes	1	0	6
214	L:L:?1	R:R:F285	8.04	Yes	Yes	1	0	7
215	R:R:I290	R:R:L286	7.14	No	No	0	6	5
216	R:R:N287	R:R:N291	6.81	No	Yes	0	9	9
217	R:R:F294	R:R:Y295	7.22	Yes	No	0	7	9
218	R:R:F296	R:R:F302	8.57	Yes	No	0	6	8
219	R:R:F296	R:R:L306	7.31	Yes	No	0	6	7
220	R:R:D300	R:R:R303	8.34	No	No	0	5	8
221	R:R:H301	R:R:M305	6.57	No	No	0	6	4
222	R:R:A237	R:R:Y207	4	No	Yes	0	8	9
223	R:R:C95	R:R:P163	3.77	No	Yes	0	9	5
224	R:R:F115	R:R:I118	3.77	Yes	No	0	6	6
225	R:R:F138	R:R:I142	3.77	No	No	0	4	5
226	R:R:T280	R:R:Y248	3.75	No	Yes	0	7	7
227	R:R:F294	R:R:M236	3.73	Yes	No	0	7	5
228	R:R:F276	R:R:M251	3.73	No	No	0	5	4
229	R:R:F294	R:R:L233	3.65	Yes	No	0	7	8
230	R:R:F296	R:R:L297	3.65	Yes	No	0	6	7
231	R:R:G40	R:R:I43	3.53	No	No	0	8	6
232	R:R:P247	R:R:T246	3.5	No	Yes	0	9	5
233	R:R:P247	R:R:T280	3.5	No	No	0	9	7
234	R:R:D180	R:R:Y183	3.45	No	No	0	3	2
235	R:R:G37	R:R:L73	3.42	No	Yes	0	8	6
236	R:R:I110	R:R:P199	3.39	No	Yes	0	8	8
237	R:R:I198	R:R:P199	3.39	No	Yes	0	6	8
238	R:R:E130	R:R:Y126	3.37	No	Yes	0	5	6
239	R:R:K229	R:R:P230	3.35	No	No	0	7	7
240	R:R:L214	R:R:P230	3.28	No	No	0	7	7
241	R:R:L225	R:R:P226	3.28	No	Yes	0	3	5
242	R:R:S66	R:R:V45	3.23	No	No	0	9	8
243	R:R:D92	R:R:P163	3.22	No	Yes	0	2	5
244	R:R:V289	R:R:V36	3.21	No	No	0	8	6
245	R:R:C11	R:R:L15	3.17	No	No	0	7	7
246	R:R:T75	R:R:V101	3.17	No	No	0	6	5
247	R:R:T114	R:R:V202	3.17	No	No	0	7	7
248	R:R:T151	R:R:V148	3.17	No	No	0	4	5
249	R:R:C204	R:R:L200	3.17	No	No	0	5	6
250	R:R:A104	R:R:L154	3.15	No	Yes	0	5	7
251	R:R:A257	R:R:L185	3.15	No	No	0	4	4
252	R:R:I273	R:R:T269	3.04	No	No	0	5	1
253	R:R:A17	R:R:E18	3.02	No	Yes	0	2	5
254	R:R:F296	R:R:G47	3.01	Yes	No	0	6	7
255	R:R:L15	R:R:V271	2.98	No	No	0	7	2
256	R:R:L152	R:R:V148	2.98	No	No	0	4	5
257	R:R:D92	R:R:V93	2.92	No	No	0	2	2
258	R:R:I60	R:R:K136	2.91	Yes	No	0	7	1
259	R:R:Q270	R:R:T269	2.83	No	No	0	3	1
260	R:R:G91	R:R:W88	2.81	No	Yes	0	8	8
261	R:R:L227	R:R:N218	2.75	No	No	0	6	4
262	R:R:L231	R:R:N232	2.75	No	No	0	6	5
263	R:R:E137	R:R:K135	2.7	No	No	0	3	6
264	R:R:L212	R:R:Q216	2.66	No	No	0	3	5
265	R:R:E153	R:R:L194	2.65	No	No	0	5	5
266	R:R:I273	R:R:R255	2.51	No	No	0	5	5
267	R:R:I80	R:R:Y30	2.42	No	Yes	0	6	8
268	R:R:L306	R:R:Y46	2.34	No	No	0	7	4
269	R:R:L155	R:R:Y100	2.34	No	Yes	0	4	6
270	R:R:F302	R:R:H301	2.26	No	No	0	8	6
271	R:R:G179	R:R:S178	1.86	No	No	0	1	3
272	R:R:P163	R:R:V164	1.77	Yes	No	0	5	1
273	R:R:G31	R:R:I80	1.76	No	No	0	5	6
274	R:R:G40	R:R:L39	1.71	No	No	0	8	4
275	R:R:G179	R:R:L160	1.71	No	No	0	1	5
276	R:R:G261	R:R:L260	1.71	No	No	0	2	1
277	R:R:A211	R:R:V234	1.7	No	No	0	5	8
278	R:R:A224	R:R:V221	1.7	No	No	0	2	3
279	R:R:L76	R:R:P77	1.64	No	No	0	8	8
280	R:R:C190	R:R:I186	1.64	No	No	0	4	4
281	R:R:N162	R:R:P163	1.63	No	Yes	0	4	5
282	R:R:S97	R:R:V93	1.62	No	No	0	5	2
283	R:R:S242	R:R:V243	1.62	No	No	0	6	6
284	R:R:V239	R:R:V243	1.6	No	No	0	5	6
285	R:R:S242	R:R:T246	1.6	No	Yes	0	6	5
286	R:R:T42	R:R:V38	1.59	No	No	0	4	6
287	R:R:C74	R:R:L70	1.59	No	No	0	5	8
288	R:R:T246	R:R:V250	1.59	Yes	No	0	5	7
289	R:R:A211	R:R:L231	1.58	No	No	0	5	6
290	R:R:A84	R:R:N85	1.56	No	No	0	5	3
291	R:R:I80	R:R:S27	1.55	No	No	0	6	5
292	R:R:I273	R:R:S258	1.55	No	No	0	5	2
293	R:R:I49	R:R:V45	1.54	No	No	0	4	8
294	R:R:I235	R:R:V239	1.54	No	No	0	4	5
295	R:R:I123	R:R:I124	1.47	No	No	0	8	8
296	R:R:I198	R:R:L193	1.43	No	No	0	6	5
297	R:R:D300	R:R:K229	1.38	No	No	0	5	7
298	R:R:E33	R:R:I32	1.37	No	No	0	7	6
299	R:R:A20	R:R:Y24	1.33	No	No	0	3	3
300	R:R:H131	R:R:L132	1.29	No	No	0	4	4
301	R:R:F29	R:R:I28	1.26	No	No	0	5	6
302	R:R:K209	R:R:Y208	1.19	No	No	0	4	3
303	R:R:N87	R:R:W88	1.13	No	Yes	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:E18	7.218	5	0	5
2	R:R:Y30	7.58571	7	1	8
3	R:R:N41	6.8725	4	0	9
4	R:R:Y48	7.415	4	0	7
5	R:R:I60	4.48	4	0	7
6	R:R:D69	7.7175	4	0	9
7	R:R:F72	9.4475	4	1	7
8	R:R:L73	4.0475	4	0	6
9	R:R:Y83	6.382	5	1	5
10	R:R:W88	5.875	6	0	8
11	R:R:Y90	9.185	4	3	7
12	R:R:Y100	4.1775	4	0	6
13	R:R:L102	6.8	4	1	7
14	R:R:Y107	8.135	4	1	7
15	R:R:F112	9.035	4	2	8
16	R:R:F115	6.63	4	5	6
17	R:R:Y121	7.3725	4	0	8
18	R:R:Y126	9.17	4	0	6
19	R:R:Q134	5.5725	4	4	7
20	R:R:W147	7.2425	4	2	9
21	R:R:L154	4.2025	4	1	7
22	R:R:I157	6.51	4	1	4
23	R:R:P163	2.5975	4	0	5
24	R:R:D174	8.8525	4	1	5
25	R:R:F175	6.93	5	1	4
26	R:R:Y187	7.118	5	1	5
27	R:R:F196	8.12833	6	1	8
28	R:R:P199	4.0225	4	0	8
29	R:R:Y207	6.63333	6	1	9
30	R:R:P226	7.6425	4	0	5
31	R:R:F241	7.65	5	1	9
32	R:R:F245	10.1225	4	1	8
33	R:R:T246	3.9425	4	0	5
34	R:R:Y248	7.39	6	1	7
35	R:R:H249	10.624	5	1	8
36	R:R:R252	8.36	6	1	6
37	R:R:Y277	11.7825	4	1	5
38	R:R:R281	12.195	6	1	6
39	R:R:F285	7.51	6	1	7
40	R:R:N291	7.1475	4	6	9
41	R:R:F294	4.905	4	0	7
42	R:R:F296	6.96	6	0	6
43	L:L:?1	10.5	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E18	R:R:W14	12.28	11.99	Yes	No	0	5	5
2	R:R:V272	R:R:W14	15.5574	13.48	No	No	0	3	5
3	R:R:R281	R:R:Y248	34.5456	4.12	Yes	Yes	1	6	7
4	R:R:T280	R:R:Y248	22.7256	3.75	No	Yes	0	7	7
5	R:R:M251	R:R:T280	22.2604	9.03	No	No	0	4	7
6	R:R:F276	R:R:M251	18.9301	3.73	No	No	0	5	4
7	R:R:F276	R:R:V272	17.249	5.24	No	No	0	5	3
8	L:L:?1	R:R:R281	12.354	28.65	Yes	Yes	1	0	6
9	R:R:P282	R:R:Y30	12.8932	11.13	No	Yes	1	5	8
10	R:R:R281	R:R:Y30	16.4191	5.14	Yes	Yes	1	6	8
11	R:R:L26	R:R:Y30	26.7907	8.21	No	Yes	0	6	8
12	R:R:I278	R:R:L26	29.0162	5.71	No	No	0	4	6
13	R:R:L76	R:R:Y30	44.3146	5.86	No	Yes	0	8	8
14	R:R:L73	R:R:L76	46.0062	4.15	Yes	No	0	6	8
15	R:R:N41	R:R:P292	44.2882	9.77	Yes	No	0	9	9
16	R:R:L73	R:R:N41	40.4557	4.12	Yes	Yes	0	6	9
17	R:R:D69	R:R:S288	86.0073	8.83	Yes	No	0	9	9
18	R:R:F72	R:R:S288	79.2938	9.25	Yes	No	0	7	9
19	R:R:F285	R:R:F72	29.307	13.93	Yes	Yes	1	7	7
20	R:R:P292	R:R:V44	36.5914	5.3	No	No	0	9	9
21	R:R:F296	R:R:V44	34.6408	7.87	Yes	No	0	6	9
22	R:R:F296	R:R:Y48	16.7257	11.35	Yes	Yes	0	6	7
23	R:R:D69	R:R:S109	100	5.89	Yes	No	0	9	9
24	R:R:S109	R:R:S68	98.5727	4.89	No	No	0	9	8
25	R:R:S68	R:R:W147	90.1781	6.18	No	Yes	2	8	9
26	R:R:F112	R:R:W147	86.7738	5.01	Yes	Yes	2	8	9
27	R:R:F112	R:R:I146	75.8947	12.56	Yes	No	0	8	7
28	R:R:F115	R:R:I146	72.6754	7.54	Yes	No	0	6	7
29	R:R:F115	R:R:I118	57.7311	3.77	Yes	No	0	6	6
30	R:R:F206	R:R:I118	56.0184	7.54	No	No	0	8	6
31	R:R:F206	R:R:Y121	44.9913	10.32	No	Yes	0	8	8
32	R:R:K125	R:R:Y121	34.3553	8.36	No	Yes	0	7	8
33	R:R:K125	R:R:Y126	32.521	17.91	No	Yes	0	7	6
34	R:R:Q134	R:R:Y126	19.3847	4.51	Yes	Yes	0	7	6
35	R:R:F112	R:R:N64	10.0122	13.29	Yes	No	2	8	9
36	R:R:L113	R:R:N291	39.1288	5.49	No	Yes	6	8	9
37	R:R:N287	R:R:N291	24.7185	6.81	No	Yes	0	9	9
38	R:R:F245	R:R:N287	23.9256	13.29	Yes	No	0	8	9
39	R:R:F196	R:R:F245	23.0163	5.36	Yes	Yes	1	8	8
40	R:R:F196	R:R:T246	17.3072	9.08	Yes	Yes	0	8	5
41	R:R:F196	R:R:H249	51.2132	19.23	Yes	Yes	1	8	8
42	R:R:H249	R:R:Y248	21.2296	6.53	Yes	Yes	1	8	7
43	R:R:R120	R:R:Y207	19.612	8.23	No	Yes	0	9	9
44	R:R:M203	R:R:Y207	16.1654	4.79	No	Yes	1	8	9
45	R:R:F241	R:R:M203	18.9301	9.95	Yes	No	1	9	8
46	R:R:F196	R:R:F241	23.4604	5.36	Yes	Yes	1	8	9
47	L:L:?1	R:R:L102	13.1205	5.22	Yes	Yes	1	0	7
48	R:R:L106	R:R:Y107	22.2763	7.03	No	Yes	0	8	7
49	R:R:H249	R:R:Y107	10.5461	7.62	Yes	Yes	1	8	7
50	L:L:?1	R:R:L79	22.5194	6.53	Yes	No	1	0	6
51	R:R:L79	R:R:N98	22.4719	4.12	No	No	0	6	4
52	R:R:L102	R:R:T75	22.4613	7.37	Yes	No	0	7	6
53	R:R:M78	R:R:N98	38.1826	15.43	No	No	0	7	4
54	R:R:M78	R:R:W88	22.3873	6.98	No	Yes	0	7	8
55	R:R:M78	R:R:Y90	15.0922	8.38	No	Yes	0	7	7
56	R:R:C95	R:R:W88	13.2421	7.84	No	Yes	0	9	8
57	L:L:?1	R:R:R99	10.2395	5.73	Yes	No	1	0	6
58	R:R:F175	R:R:I157	13.5169	11.3	Yes	Yes	1	4	4
59	R:R:F175	R:R:R252	32.2726	5.34	Yes	Yes	1	4	6
60	R:R:I157	R:R:L154	15.1768	4.28	Yes	Yes	1	4	7
61	R:R:L154	R:R:Y100	26.796	4.69	Yes	Yes	0	7	6
62	R:R:T151	R:R:Y100	13.4429	4.99	No	Yes	0	4	6
63	R:R:F175	R:R:Y187	13.057	4.13	Yes	Yes	1	4	5
64	R:R:L154	R:R:Y187	20.2833	4.69	Yes	Yes	1	7	5
65	R:R:F175	R:R:H103	33.0602	9.05	Yes	No	0	4	5
66	L:L:?1	R:R:H103	34.0065	7.28	Yes	No	0	0	5
67	R:R:L191	R:R:Y107	15.05	11.72	No	Yes	0	5	7
68	R:R:F245	R:R:I110	11.3179	10.05	Yes	No	1	8	8
69	R:R:R120	R:R:Y295	14.4632	6.17	No	No	0	9	9
70	R:R:L113	R:R:Y295	37.5905	4.69	No	No	0	8	9
71	R:R:S242	R:R:T246	14.8332	1.6	No	Yes	0	6	5
72	R:R:S242	R:R:V243	13.0306	1.62	No	No	0	6	6
73	R:R:V239	R:R:V243	11.7883	1.6	No	No	0	5	6
74	R:R:M236	R:R:V239	10.6888	7.61	No	No	0	5	5
75	R:R:F294	R:R:M236	11.0483	3.73	Yes	No	0	7	5
76	R:R:F294	R:R:Y295	37.6434	7.22	Yes	No	0	7	9
77	R:R:I110	R:R:P199	16.2975	3.39	No	Yes	0	8	8
78	R:R:F175	R:R:N184	39.0865	4.83	Yes	No	0	4	3
79	R:R:L160	R:R:N184	30.1633	5.49	No	No	0	5	3
80	R:R:L160	R:R:Y183	23.3599	8.21	No	No	0	5	2
81	R:R:I278	R:R:N274	26.1617	7.08	No	No	0	4	3
82	R:R:N274	R:R:R255	23.2965	12.05	No	No	0	3	5
83	R:R:D180	R:R:Y183	18.7715	3.45	No	No	0	3	2
84	R:R:V234	R:R:Y207	11.3602	8.83	No	Yes	0	8	9
85	R:R:K209	R:R:Y208	11.635	1.19	No	No	0	4	3
86	R:R:L214	R:R:P230	17.8358	3.28	No	No	0	7	7
87	R:R:K229	R:R:P230	20.3785	3.35	No	No	0	7	7
88	R:R:K229	R:R:L233	27.7317	4.23	No	No	0	7	8
89	R:R:F294	R:R:L233	32.5474	3.65	Yes	No	0	7	8
90	R:R:L214	R:R:L227	15.494	4.15	No	No	0	7	6
91	R:R:L227	R:R:N218	12.9355	2.75	No	No	0	6	4
92	R:R:N218	R:R:P226	10.3663	4.89	No	Yes	0	4	5
93	R:R:C95	R:R:P163	11.3813	3.77	No	Yes	0	9	5
94	R:R:I273	R:R:R255	11.7302	2.51	No	No	0	5	5
95	L:L:?1	R:R:Y30	20.9653	11.06	Yes	Yes	1	0	8
96	L:L:?1	R:R:F285	11.6509	8.04	Yes	Yes	1	0	7
97	R:R:F72	R:R:L102	30.7607	9.74	Yes	Yes	1	7	7
98	R:R:D69	R:R:N291	56.214	9.42	Yes	Yes	0	9	9
99	R:R:F72	R:R:L106	22.7943	4.87	Yes	No	0	7	8
100	R:R:N98	R:R:T75	17.7037	10.24	No	No	0	4	6
101	R:R:L191	R:R:Y187	13.4006	8.21	No	Yes	0	5	5
102	R:R:F285	R:R:Y30	10.932	9.28	Yes	Yes	1	7	8
103	R:R:D69	R:R:N41	39.0072	6.73	Yes	Yes	0	9	9
104	R:R:L73	R:R:S288	22.9582	4.5	Yes	No	0	6	9
105	R:R:H249	R:R:R252	22.1547	10.16	Yes	Yes	1	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E22	R:R:Y83	8.98	0	No	Yes	5	5	2	1
R:R:L26	R:R:Y30	8.21	0	No	Yes	6	8	2	1
R:R:L26	R:R:Y83	5.86	0	No	Yes	6	5	2	1
R:R:L76	R:R:Y30	5.86	0	No	Yes	8	8	2	1
R:R:R281	R:R:Y30	5.14	1	Yes	Yes	6	8	1	1
R:R:P282	R:R:Y30	11.13	1	No	Yes	5	8	2	1
R:R:F285	R:R:Y30	9.28	1	Yes	Yes	7	8	1	1
L:L:?1	R:R:Y30	11.06	1	Yes	Yes	0	8	0	1
R:R:E33	R:R:F285	4.66	0	No	Yes	7	7	2	1
R:R:F72	R:R:L102	9.74	1	Yes	Yes	7	7	2	1
R:R:F285	R:R:F72	13.93	1	Yes	Yes	7	7	1	2
R:R:N98	R:R:T75	10.24	0	No	No	4	6	2	2
R:R:L102	R:R:T75	7.37	1	Yes	No	7	6	1	2
R:R:L79	R:R:Y83	4.69	1	No	Yes	6	5	1	1
R:R:L79	R:R:N98	4.12	1	No	No	6	4	1	2
L:L:?1	R:R:L79	6.53	1	Yes	No	0	6	0	1
R:R:D174	R:R:Y83	5.75	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:Y83	6.63	1	Yes	Yes	0	5	0	1
R:R:I161	R:R:R99	7.52	0	No	No	4	6	2	1
R:R:D174	R:R:R99	5.96	1	Yes	No	5	6	1	1
L:L:?1	R:R:R99	5.73	1	Yes	No	0	6	0	1
R:R:F285	R:R:L102	4.87	1	Yes	Yes	7	7	1	1
L:L:?1	R:R:L102	5.22	1	Yes	Yes	0	7	0	1
R:R:F175	R:R:H103	9.05	1	Yes	No	4	5	2	1
L:L:?1	R:R:H103	7.28	1	Yes	No	0	5	0	1
R:R:D174	R:R:R281	8.34	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:D174	15.36	1	Yes	Yes	0	5	0	1
R:R:Y248	R:R:Y277	10.92	1	Yes	Yes	7	5	2	2
R:R:R281	R:R:Y248	4.12	1	Yes	Yes	6	7	1	2
R:R:R281	R:R:Y277	22.64	1	Yes	Yes	6	5	1	2
R:R:F285	R:R:R281	4.28	1	Yes	Yes	7	6	1	1
L:L:?1	R:R:R281	28.65	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F285	8.04	1	Yes	Yes	0	7	0	1
R:R:I80	R:R:Y30	2.42	0	No	Yes	6	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YKX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.05
Number of Linked Nodes	264
Number of Links	303
Number of Hubs	43
Number of Links mediated by Hubs	161
Number of Communities	6
Number of Nodes involved in Communities	49
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	57636
Length Of Smallest Path	3
Average Path Length	13.3262
Length of Longest Path	32
Minimum Path Strength	1.57
Average Path Strength	7.09986
Maximum Path Strength	25.645
Minimum Path Correlation	0.7
Average Path Correlation	0.925638
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	50.2541
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.2793
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • macrophage activation involved in immune response • immune response • cell activation • cell activation involved in immune response • myeloid cell activation involved in immune response • myeloid leukocyte activation • leukocyte activation • immune effector process • macrophage activation • leukocyte activation involved in immune response • regulation of defense response • regulation of response to external stimulus • defense response • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • positive regulation of defense response • inflammatory response • response to metal ion • response to calcium ion • chemotaxis • positive regulation of locomotion • regulation of chemotaxis • positive regulation of chemotaxis • taxis • regulation of locomotion • locomotion • regulation of systemic arterial blood pressure by renin-angiotensin • renin secretion into blood stream • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • renal system process • regulation of blood pressure • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • regulation of systemic arterial blood pressure • endocrine process • regulation of protein metabolic process • regulation of macromolecule metabolic process • regulation of angiotensin metabolic process • protein metabolic process • macromolecule metabolic process • multicellular organismal-level homeostasis • homeostatic process • energy homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MAE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	MAE
Name	Maleic acid
Synonyms	(Z)-2-butenedioic acid
Identifier
Formula	C4 H4 O4
Molecular Weight	116.072
SMILES
PubChem	444266
Formal Charge	0
Total Atoms	12
Total Chiral Atoms	0
Total Bonds	11
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXA5
Sequence	>8YKX_nogp_Chain_R C K N W L A A E A A L E K Y Y L S I F Y G I E F V V G V L G N T I V V Y G Y I W N S S N I Y L F N L S V S D L A F L C T L P M L I R S Y A N G N W I Y G D V L C I S N R Y V L H A N L Y T S I L F L T F I S I D R Y L I I K Y P F R E H L L Q K K E F A I L I S L A I W V L V T L E L L P I L P L I N P V T C N D F A S S G D P N Y N L I Y S M C L T L L G F L I P L F V M C F F Y Y K I A L F L K Q R N R Q V A T A L P L E K P L N L V I M A V V I F S V L F T P Y H V M R N V R I A S R L G T Q V V I N S F Y I V T R P L A F L N S V I N P V F Y F L L G D H F R D M L M N Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6IBB	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	-	-	-	2.12	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	6RNK	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	NF-56-EJ40	-	-	1.94	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	6Z10	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	PubChem 154585554	-	-	2.27	2020-09-16	doi.org/10.1021/acs.jmedchem.0c01020
	8JPN	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ1	2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPN (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	chim(Gs-CtGq)/β1/γ1	3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8YKW	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ1	2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKW (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-	Gi1/β1/γ1	2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-		2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8WOG	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ2	2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WOG (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ2	3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1 (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8YKV	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-	Gi1/β1/γ2	2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKV (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-		2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.