psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q267	R:R:T10	4.25	No	No	0	7	9
2	R:R:C11	R:R:W14	3.92	No	Yes	0	7	5
3	R:R:C11	R:R:C268	7.28	No	No	0	7	1
4	R:R:V272	R:R:W14	11.03	No	Yes	0	3	5
5	R:R:L15	R:R:V271	5.96	No	No	0	7	2
6	R:R:E18	R:R:V271	4.28	No	No	0	5	2
7	R:R:E18	R:R:N274	10.52	No	No	0	5	3
8	R:R:L21	R:R:Y25	8.21	No	Yes	0	4	4
9	R:R:E22	R:R:I278	5.47	No	No	0	5	4
10	R:R:K23	R:R:Y24	14.33	No	No	0	4	3
11	R:R:F29	R:R:Y25	9.28	No	Yes	5	5	4
12	R:R:V279	R:R:Y25	5.05	No	Yes	0	5	4
13	R:R:P282	R:R:Y25	9.74	No	Yes	5	5	4
14	R:R:L26	R:R:Y30	5.86	No	Yes	0	6	8
15	R:R:L26	R:R:Y83	5.86	No	No	0	6	5
16	R:R:I278	R:R:L26	5.71	No	No	0	4	6
17	R:R:E33	R:R:F29	10.49	Yes	No	0	7	5
18	R:R:F29	R:R:P282	5.78	No	No	5	5	5
19	R:R:F285	R:R:Y30	9.28	No	Yes	0	7	8
20	L:L:?1	R:R:Y30	4.16	Yes	Yes	0	0	8
21	R:R:E33	R:R:F285	5.83	Yes	No	0	7	7
22	R:R:E33	R:R:L286	6.63	Yes	Yes	0	7	5
23	R:R:F34	R:R:V38	6.55	No	No	0	7	6
24	R:R:F34	R:R:P77	8.67	No	No	0	7	8
25	R:R:G37	R:R:V289	3.68	No	No	0	8	8
26	R:R:D69	R:R:N41	6.73	Yes	No	0	9	9
27	R:R:L70	R:R:N41	4.12	No	No	0	8	9
28	R:R:N41	R:R:P292	6.52	No	No	0	9	9
29	R:R:I43	R:R:Y46	13.3	No	Yes	0	6	4
30	R:R:F296	R:R:V44	14.42	Yes	No	0	6	9
31	R:R:F63	R:R:V45	5.24	Yes	No	0	6	8
32	R:R:F50	R:R:Y46	9.28	No	Yes	0	4	4
33	R:R:L310	R:R:Y46	9.38	No	Yes	0	6	4
34	R:R:N59	R:R:Y48	10.47	No	Yes	0	7	7
35	R:R:L62	R:R:Y48	4.69	Yes	Yes	4	8	7
36	R:R:F63	R:R:Y48	5.16	Yes	Yes	0	6	7
37	R:R:F296	R:R:Y48	10.32	Yes	Yes	4	6	7
38	R:R:F302	R:R:Y48	6.19	No	Yes	4	8	7
39	R:R:F63	R:R:I49	3.77	Yes	No	0	6	4
40	R:R:M305	R:R:S51	6.13	No	No	0	4	5
41	R:R:Q309	R:R:S51	12.99	No	No	0	5	5
42	R:R:L52	R:R:W55	7.97	No	No	0	5	6
43	R:R:L52	R:R:N59	5.49	No	No	0	5	7
44	R:R:L52	R:R:M305	7.07	No	No	0	5	4
45	R:R:K53	R:R:N54	5.6	No	No	0	5	6
46	R:R:F63	R:R:W55	11.02	Yes	No	0	6	6
47	R:R:N56	R:R:N59	10.9	No	No	0	7	7
48	R:R:N56	R:R:R129	7.23	No	Yes	0	7	5
49	R:R:S57	R:R:Y61	6.36	No	No	0	6	7
50	R:R:A139	R:R:S57	3.42	No	No	0	7	6
51	R:R:D119	R:R:S58	8.83	No	No	0	8	8
52	R:R:A139	R:R:I60	6.5	No	No	0	7	7
53	R:R:F115	R:R:Y61	7.22	No	No	6	6	7
54	R:R:I142	R:R:Y61	4.84	No	No	6	5	7
55	R:R:I116	R:R:L62	4.28	No	Yes	0	9	8
56	R:R:L62	R:R:Y295	3.52	Yes	Yes	0	8	9
57	R:R:F296	R:R:L62	12.18	Yes	Yes	4	6	8
58	R:R:F63	R:R:S66	3.96	Yes	No	0	6	9
59	R:R:F63	R:R:V67	3.93	Yes	No	0	6	7
60	R:R:F112	R:R:N64	14.5	Yes	No	3	8	9
61	R:R:N64	R:R:S143	8.94	No	No	3	9	7
62	R:R:D69	R:R:L65	4.07	Yes	Yes	3	9	9
63	R:R:L113	R:R:L65	5.54	No	Yes	0	8	9
64	R:R:L65	R:R:N291	5.49	Yes	No	3	9	9
65	R:R:S68	R:R:W147	4.94	No	No	0	8	9
66	R:R:D69	R:R:S109	4.42	Yes	No	0	9	9
67	R:R:D69	R:R:N291	6.73	Yes	No	3	9	9
68	R:R:A71	R:R:N105	4.69	No	No	0	6	8
69	R:R:F72	R:R:L102	6.09	Yes	Yes	0	7	7
70	R:R:F72	R:R:N105	3.62	Yes	No	0	7	8
71	R:R:F72	R:R:L106	4.87	Yes	No	0	7	8
72	R:R:F285	R:R:F72	13.93	No	Yes	0	7	7
73	R:R:F72	R:R:S288	3.96	Yes	No	0	7	9
74	R:R:N98	R:R:T75	5.85	No	No	0	4	6
75	R:R:T75	R:R:V101	4.76	No	No	0	6	5
76	R:R:L102	R:R:T75	8.84	Yes	No	0	7	6
77	R:R:M78	R:R:W88	3.49	No	Yes	1	7	8
78	R:R:M78	R:R:Y90	9.58	No	Yes	1	7	7
79	R:R:L94	R:R:M78	7.07	No	No	1	6	7
80	R:R:L79	R:R:N98	4.12	No	No	0	6	4
81	R:R:L79	R:R:R99	3.64	No	Yes	1	6	6
82	L:L:?1	R:R:L79	3.69	Yes	No	1	0	6
83	R:R:R81	R:R:Y90	12.35	No	Yes	0	5	7
84	R:R:S82	R:R:W88	6.18	No	Yes	0	5	8
85	L:L:?1	R:R:Y83	5.2	Yes	No	0	0	5
86	R:R:I89	R:R:N87	4.25	No	No	0	3	4
87	R:R:W88	R:R:Y90	11.58	Yes	Yes	1	8	7
88	R:R:C95	R:R:W88	10.45	No	Yes	1	9	8
89	R:R:C172	R:R:W88	10.45	No	Yes	1	9	8
90	R:R:I89	R:R:Y90	7.25	No	Yes	0	3	7
91	R:R:L94	R:R:Y90	7.03	No	Yes	1	6	7
92	R:R:D92	R:R:P163	12.88	No	No	0	2	5
93	R:R:C172	R:R:C95	5.46	No	No	1	9	9
94	R:R:I161	R:R:I96	4.42	No	No	0	4	7
95	R:R:I96	R:R:P163	3.39	No	No	0	7	5
96	R:R:I161	R:R:R99	7.52	No	Yes	0	4	6
97	R:R:C172	R:R:R99	4.18	No	Yes	1	9	6
98	L:L:?1	R:R:R99	16.18	Yes	Yes	1	0	6
99	R:R:T151	R:R:Y100	3.75	No	Yes	0	4	6
100	R:R:L154	R:R:Y100	3.52	No	Yes	0	7	6
101	R:R:H103	R:R:L102	3.86	No	Yes	1	5	7
102	L:L:?1	R:R:L102	7.37	Yes	Yes	1	0	7
103	R:R:F175	R:R:H103	4.53	Yes	No	1	4	5
104	L:L:?1	R:R:H103	7.99	Yes	No	1	0	5
105	R:R:L191	R:R:Y107	10.55	No	No	0	5	7
106	R:R:H249	R:R:Y107	7.62	Yes	No	1	8	7
107	R:R:R252	R:R:Y107	6.17	Yes	No	1	6	7
108	R:R:F112	R:R:T108	3.89	Yes	No	3	8	7
109	R:R:T108	R:R:W147	9.7	No	No	3	7	9
110	R:R:T108	R:R:V150	7.93	No	No	0	7	8
111	R:R:I110	R:R:P199	3.39	No	Yes	0	8	8
112	R:R:F241	R:R:I110	6.28	Yes	No	1	9	8
113	R:R:F245	R:R:I110	6.28	Yes	No	1	8	8
114	R:R:I146	R:R:L111	4.28	No	No	0	7	6
115	R:R:F112	R:R:S143	5.28	Yes	No	3	8	7
116	R:R:F112	R:R:I146	6.28	Yes	No	0	8	7
117	R:R:F112	R:R:W147	7.02	Yes	No	3	8	9
118	R:R:L113	R:R:Y295	4.69	No	Yes	0	8	9
119	R:R:P199	R:R:T114	3.5	Yes	No	0	8	7
120	R:R:M203	R:R:T114	4.52	No	No	0	8	7
121	R:R:F115	R:R:I142	7.54	No	No	6	6	5
122	R:R:F115	R:R:I146	6.28	No	No	0	6	7
123	R:R:I116	R:R:R120	5.01	No	No	0	9	9
124	R:R:M203	R:R:S117	6.13	No	No	7	8	9
125	R:R:S117	R:R:Y207	6.36	No	Yes	7	9	9
126	R:R:F206	R:R:I118	7.54	No	No	0	8	6
127	R:R:R120	R:R:Y207	9.26	No	Yes	0	9	9
128	R:R:R120	R:R:Y295	4.12	No	Yes	0	9	9
129	R:R:L122	R:R:Y121	4.69	No	Yes	2	5	8
130	R:R:I124	R:R:Y121	4.84	No	Yes	0	8	8
131	R:R:K125	R:R:Y121	11.94	No	Yes	0	7	8
132	R:R:F206	R:R:Y121	7.22	No	Yes	2	8	8
133	R:R:K209	R:R:Y121	11.94	No	Yes	2	4	8
134	R:R:I210	R:R:Y121	6.04	No	Yes	0	8	8
135	R:R:L122	R:R:Y126	3.52	No	Yes	2	5	6
136	R:R:H131	R:R:L122	3.86	Yes	No	2	4	5
137	R:R:I123	R:R:R129	6.26	No	Yes	2	8	5
138	R:R:I123	R:R:Q134	5.49	No	No	2	8	7
139	R:R:F213	R:R:I124	18.84	No	No	0	5	8
140	R:R:K125	R:R:Y126	10.75	No	Yes	0	7	6
141	R:R:E130	R:R:Y126	7.86	No	Yes	0	5	6
142	R:R:H131	R:R:Y126	14.16	Yes	Yes	2	4	6
143	R:R:E130	R:R:F128	7	No	No	0	5	5
144	R:R:Q134	R:R:R129	7.01	No	Yes	2	7	5
145	R:R:H131	R:R:L133	7.71	Yes	No	0	4	3
146	R:R:H131	R:R:Q134	3.71	Yes	No	2	4	7
147	R:R:F138	R:R:L132	9.74	No	No	0	4	4
148	R:R:E137	R:R:K135	9.45	No	No	0	3	6
149	R:R:E153	R:R:L149	3.98	No	No	0	5	4
150	R:R:E153	R:R:L194	3.98	No	No	0	5	5
151	R:R:P156	R:R:Y187	8.34	No	Yes	0	8	5
152	R:R:I157	R:R:I161	4.42	Yes	No	0	4	4
153	R:R:F175	R:R:I157	6.28	Yes	Yes	1	4	4
154	R:R:I157	R:R:Y187	7.25	Yes	Yes	1	4	5
155	R:R:P159	R:R:Y183	5.56	No	No	0	4	2
156	R:R:L160	R:R:Y183	8.21	No	No	0	5	2
157	R:R:L160	R:R:N184	9.61	No	Yes	0	5	3
158	R:R:N162	R:R:P163	8.15	No	No	0	4	5
159	R:R:N173	R:R:V164	4.43	No	No	0	4	1
160	R:R:D167	R:R:T166	7.23	No	No	0	4	1
161	R:R:N173	R:R:S178	7.45	No	No	0	4	3
162	R:R:D174	R:R:S177	8.83	Yes	No	0	5	4
163	R:R:D174	R:R:Y277	4.6	Yes	Yes	1	5	5
164	R:R:D174	R:R:R281	4.76	Yes	No	1	5	6
165	L:L:?1	R:R:D174	3.61	Yes	Yes	1	0	5
166	R:R:F175	R:R:N184	4.83	Yes	Yes	0	4	3
167	R:R:F175	R:R:Y187	4.13	Yes	Yes	1	4	5
168	R:R:F175	R:R:S188	3.96	Yes	No	1	4	5
169	R:R:F175	R:R:R252	6.41	Yes	Yes	1	4	6
170	R:R:A176	R:R:R255	4.15	No	Yes	1	6	5
171	R:R:A176	R:R:Y277	5.34	No	Yes	1	6	5
172	R:R:R255	R:R:S177	9.22	Yes	No	0	5	4
173	R:R:L260	R:R:P181	4.93	No	No	0	1	1
174	R:R:L260	R:R:N182	4.12	No	No	0	1	1
175	R:R:I256	R:R:N184	8.5	No	Yes	0	5	3
176	R:R:N184	R:R:R259	3.62	Yes	No	0	3	3
177	R:R:I256	R:R:L185	5.71	No	No	0	5	4
178	R:R:L191	R:R:Y187	8.21	No	Yes	0	5	5
179	R:R:R252	R:R:S188	7.91	Yes	No	1	6	5
180	R:R:N253	R:R:S188	5.96	No	No	0	6	5
181	R:R:M189	R:R:N253	7.01	No	No	0	5	6
182	R:R:H249	R:R:T192	6.85	Yes	No	1	8	6
183	R:R:R252	R:R:T192	3.88	Yes	No	1	6	6
184	R:R:N253	R:R:T192	7.31	No	No	0	6	6
185	R:R:G195	R:R:P199	4.06	No	Yes	0	6	8
186	R:R:F196	R:R:L197	3.65	Yes	No	0	8	4
187	R:R:F196	R:R:L200	3.65	Yes	Yes	1	8	6
188	R:R:F196	R:R:F241	4.29	Yes	Yes	1	8	9
189	R:R:F196	R:R:F245	4.29	Yes	Yes	1	8	8
190	R:R:F196	R:R:T246	5.19	Yes	No	0	8	5
191	R:R:F196	R:R:H249	19.23	Yes	Yes	1	8	8
192	R:R:I198	R:R:P199	3.39	No	Yes	0	6	8
193	R:R:F241	R:R:L200	4.87	Yes	Yes	1	9	6
194	R:R:L200	R:R:S242	4.5	Yes	No	0	6	6
195	R:R:M203	R:R:Y207	4.79	No	Yes	7	8	9
196	R:R:F205	R:R:K209	14.89	No	No	0	4	4
197	R:R:F206	R:R:K209	4.96	No	No	2	8	4
198	R:R:V234	R:R:Y207	8.83	No	Yes	0	8	9
199	R:R:A237	R:R:Y207	4	No	Yes	0	8	9
200	R:R:V238	R:R:Y207	5.05	No	Yes	0	8	9
201	R:R:L212	R:R:Y208	14.07	No	No	0	3	3
202	R:R:K215	R:R:L212	4.23	No	No	0	4	3
203	R:R:L214	R:R:P230	6.57	No	No	0	7	7
204	R:R:L214	R:R:L231	4.15	No	Yes	0	7	6
205	R:R:R217	R:R:V221	9.15	No	No	0	5	3
206	R:R:N218	R:R:P226	4.89	No	No	8	4	5
207	R:R:E228	R:R:N218	5.26	No	No	8	5	4
208	R:R:E228	R:R:P226	6.29	No	No	8	5	5
209	R:R:F294	R:R:M236	4.98	Yes	No	0	7	5
210	R:R:F241	R:R:F245	9.65	Yes	Yes	1	9	8
211	R:R:L244	R:R:L286	4.15	No	Yes	0	9	5
212	R:R:L244	R:R:N287	9.61	No	No	0	9	9
213	R:R:F245	R:R:N287	10.87	Yes	No	0	8	9
214	R:R:P247	R:R:T246	3.5	No	No	0	9	5
215	R:R:H249	R:R:Y248	4.36	Yes	Yes	1	8	7
216	R:R:R252	R:R:Y248	6.17	Yes	Yes	1	6	7
217	R:R:Y248	R:R:Y277	7.94	Yes	Yes	1	7	5
218	R:R:A284	R:R:Y248	4	No	Yes	0	8	7
219	R:R:H249	R:R:R252	5.64	Yes	Yes	1	8	6
220	R:R:M251	R:R:V254	4.56	No	No	0	4	5
221	R:R:M251	R:R:T280	4.52	No	No	0	4	7
222	R:R:R252	R:R:Y277	8.23	Yes	Yes	1	6	5
223	R:R:N274	R:R:R255	12.05	No	Yes	0	3	5
224	R:R:R255	R:R:Y277	8.23	Yes	Yes	1	5	5
225	R:R:I273	R:R:S258	4.64	No	No	0	5	2
226	R:R:Q265	R:R:Q270	5.12	No	No	9	1	3
227	R:R:Q267	R:R:Y266	10.15	No	No	0	7	5
228	R:R:T269	R:R:Y266	6.24	No	No	0	1	5
229	R:R:I278	R:R:N274	7.08	No	No	0	4	3
230	R:R:R281	R:R:Y277	17.49	No	Yes	1	6	5
231	L:L:?1	R:R:R281	14.02	Yes	No	1	0	6
232	R:R:L286	R:R:V289	4.47	Yes	No	0	5	8
233	R:R:I290	R:R:L286	4.28	No	Yes	0	6	5
234	R:R:N291	R:R:Y295	5.81	No	Yes	0	9	9
235	R:R:F294	R:R:Y295	7.22	Yes	Yes	0	7	9
236	R:R:F296	R:R:F302	9.65	Yes	No	4	6	8
237	R:R:D300	R:R:R303	9.53	No	No	0	5	8
238	R:R:D304	R:R:R303	3.57	No	No	0	4	8
239	R:R:K229	R:R:P230	3.35	No	No	0	7	7
240	R:R:L227	R:R:P230	3.28	No	No	0	6	7
241	R:R:T114	R:R:V202	3.17	No	No	0	7	7
242	R:R:C204	R:R:L200	3.17	No	Yes	0	5	6
243	R:R:T280	R:R:V279	3.17	No	No	0	7	5
244	R:R:A257	R:R:L185	3.15	No	No	0	4	4
245	R:R:I273	R:R:V254	3.07	No	No	0	5	5
246	R:R:C268	R:R:Q265	3.05	No	No	0	1	1
247	R:R:I165	R:R:T170	3.04	No	No	0	1	5
248	R:R:L73	R:R:S288	3	No	No	0	6	9
249	R:R:L70	R:R:T42	2.95	No	No	0	8	4
250	R:R:I140	R:R:I60	2.94	No	No	0	4	7
251	R:R:I60	R:R:K136	2.91	No	No	0	7	1
252	R:R:G47	R:R:Y46	2.9	No	Yes	0	7	4
253	R:R:F128	R:R:P127	2.89	No	No	0	5	8
254	R:R:P181	R:R:R259	2.88	No	No	0	1	3
255	R:R:I43	R:R:L306	2.85	No	No	0	6	7
256	R:R:I157	R:R:L154	2.85	Yes	No	0	4	7
257	R:R:I240	R:R:L244	2.85	No	No	0	7	9
258	R:R:I186	R:R:N182	2.83	No	No	0	4	1
259	R:R:K215	R:R:L231	2.82	No	Yes	0	4	6
260	R:R:K229	R:R:L233	2.82	No	No	0	7	8
261	R:R:G261	R:R:W263	2.81	No	No	0	2	1
262	R:R:L193	R:R:L197	2.77	No	No	0	5	4
263	R:R:L227	R:R:N218	2.75	No	No	0	6	4
264	R:R:E33	R:R:L76	2.65	Yes	No	0	7	8
265	R:R:R129	R:R:S58	2.64	Yes	No	0	5	8
266	R:R:F276	R:R:S275	2.64	No	No	0	5	1
267	R:R:F50	R:R:I49	2.51	No	No	0	4	4
268	R:R:F276	R:R:M251	2.49	No	No	0	5	4
269	R:R:V271	R:R:W14	2.45	No	Yes	0	2	5
270	R:R:F34	R:R:L76	2.44	No	No	0	7	8
271	R:R:F112	R:R:L65	2.44	Yes	Yes	3	8	9
272	R:R:F138	R:R:L133	2.44	No	No	0	4	3
273	R:R:F201	R:R:L197	2.44	No	No	0	3	4
274	R:R:F294	R:R:L233	2.44	Yes	No	0	7	8
275	R:R:F294	R:R:L298	2.44	Yes	No	0	7	6
276	R:R:I80	R:R:Y30	2.42	No	Yes	0	6	8
277	R:R:L155	R:R:Y100	2.34	No	Yes	0	4	6
278	R:R:L158	R:R:Y100	2.34	No	Yes	0	4	6
279	R:R:F213	R:R:Q216	2.34	No	No	0	5	5
280	R:R:Q265	R:R:W263	2.19	No	No	9	1	1
281	R:R:Q270	R:R:W263	2.19	No	No	9	3	1
282	R:R:G40	R:R:P292	2.03	No	No	0	8	9
283	R:R:G179	R:R:S178	1.86	No	No	0	1	3
284	R:R:G37	R:R:V36	1.84	No	No	0	8	6
285	R:R:G169	R:R:T166	1.82	No	No	0	1	1
286	R:R:G31	R:R:I80	1.76	No	No	0	5	6
287	R:R:G40	R:R:L39	1.71	No	No	0	8	4
288	R:R:G179	R:R:L160	1.71	No	No	0	1	5
289	R:R:G195	R:R:L194	1.71	No	No	0	6	5
290	R:R:A9	R:R:T10	1.68	No	No	0	6	9
291	R:R:D180	R:R:G179	1.68	No	No	0	3	1
292	R:R:D300	R:R:G299	1.68	No	No	0	5	8
293	R:R:C190	R:R:I186	1.64	No	No	0	4	4
294	R:R:L225	R:R:P226	1.64	No	No	0	3	5
295	R:R:S97	R:R:V101	1.62	No	No	0	5	5
296	R:R:V35	R:R:V36	1.6	No	No	0	4	6
297	R:R:V239	R:R:V243	1.6	No	No	0	5	6
298	R:R:V250	R:R:V254	1.6	No	No	0	7	5
299	R:R:T269	R:R:V272	1.59	No	No	0	1	3
300	R:R:A104	R:R:L154	1.58	No	No	0	5	7
301	R:R:A211	R:R:L231	1.58	No	Yes	0	5	6
302	R:R:I28	R:R:S27	1.55	No	No	0	6	5
303	R:R:I80	R:R:S27	1.55	No	No	0	6	5
304	R:R:I32	R:R:V36	1.54	No	No	0	6	6
305	R:R:I235	R:R:V239	1.54	No	No	0	4	5
306	R:R:L152	R:R:V148	1.49	No	No	0	4	5
307	R:R:L297	R:R:V293	1.49	No	No	0	7	6
308	R:R:L298	R:R:V293	1.49	No	No	0	6	6
309	R:R:G91	R:R:Y90	1.45	No	Yes	0	8	7
310	R:R:I235	R:R:L231	1.43	No	Yes	0	4	6
311	R:R:K135	R:R:L132	1.41	No	No	0	6	4
312	R:R:K12	R:R:N13	1.4	No	No	0	4	6
313	R:R:M307	R:R:N308	1.4	No	No	0	4	4
314	R:R:D304	R:R:M307	1.39	No	No	0	4	4
315	R:R:N85	R:R:N87	1.36	No	No	0	3	4
316	R:R:L227	R:R:R217	1.21	No	No	0	6	5
317	R:R:K264	R:R:Y266	1.19	No	No	0	3	5
318	R:R:L283	R:R:Y25	1.17	No	Yes	0	7	4
319	R:R:Q220	R:R:R219	1.17	No	No	0	2	4
320	R:R:N13	R:R:W14	1.13	No	Yes	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W14	4.6325	4	0	5
2	R:R:Y25	6.69	5	5	4
3	R:R:Y30	5.43	4	0	8
4	R:R:E33	6.4	4	0	7
5	R:R:Y46	8.715	4	0	4
6	R:R:Y48	7.366	5	4	7
7	R:R:L62	6.1675	4	4	8
8	R:R:F63	5.51333	6	0	6
9	R:R:L65	4.385	4	3	9
10	R:R:D69	5.4875	4	3	9
11	R:R:F72	6.494	5	0	7
12	R:R:W88	8.43	5	1	8
13	R:R:Y90	8.20667	6	1	7
14	R:R:R99	7.88	4	1	6
15	R:R:Y100	2.9875	4	0	6
16	R:R:L102	6.54	4	1	7
17	R:R:F112	6.56833	6	3	8
18	R:R:Y121	7.77833	6	2	8
19	R:R:Y126	9.0725	4	2	6
20	R:R:R129	5.785	4	2	5
21	R:R:H131	7.36	4	2	4
22	R:R:I157	5.2	4	1	4
23	R:R:D174	5.45	4	1	5
24	R:R:F175	5.02333	6	1	4
25	R:R:N184	6.64	4	0	3
26	R:R:Y187	6.9825	4	1	5
27	R:R:F196	6.71667	6	1	8
28	R:R:P199	3.585	4	0	8
29	R:R:L200	4.0475	4	1	6
30	R:R:Y207	6.38167	6	7	9
31	R:R:L231	2.495	4	0	6
32	R:R:F241	6.2725	4	1	9
33	R:R:F245	7.7725	4	1	8
34	R:R:Y248	5.6175	4	1	7
35	R:R:H249	8.74	5	1	8
36	R:R:R252	6.34429	7	1	6
37	R:R:R255	8.4125	4	1	5
38	R:R:Y277	8.63833	6	1	5
39	R:R:L286	4.8825	4	0	5
40	R:R:F294	4.27	4	0	7
41	R:R:Y295	5.072	5	0	9
42	R:R:F296	11.6425	4	4	6
43	L:L:?1	7.7775	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V271	R:R:W14	17.9954	2.45	No	Yes	0	2	5
2	R:R:E18	R:R:V271	20.205	4.28	No	No	0	5	2
3	R:R:E18	R:R:N274	21.2054	10.52	No	No	0	5	3
4	L:L:?1	R:R:D174	17.5002	3.61	Yes	Yes	1	0	5
5	R:R:N274	R:R:R255	21.9382	12.05	No	Yes	0	3	5
6	R:R:D174	R:R:Y277	18.3474	4.6	Yes	Yes	1	5	5
7	R:R:R255	R:R:Y277	23.093	8.23	Yes	Yes	1	5	5
8	L:L:?1	R:R:R281	16.7196	14.02	Yes	No	1	0	6
9	R:R:R281	R:R:Y277	17.5335	17.49	No	Yes	1	6	5
10	R:R:N291	R:R:Y295	17.3281	5.81	No	Yes	0	9	9
11	R:R:R120	R:R:Y295	66.7995	4.12	No	Yes	0	9	9
12	R:R:R120	R:R:Y207	95.0945	9.26	No	Yes	0	9	9
13	R:R:M203	R:R:Y207	96.3725	4.79	No	Yes	7	8	9
14	R:R:M203	R:R:T114	97.273	4.52	No	No	0	8	7
15	R:R:P199	R:R:T114	97.9681	3.5	Yes	No	0	8	7
16	R:R:I110	R:R:P199	100	3.39	No	Yes	0	8	8
17	R:R:F241	R:R:I110	46.106	6.28	Yes	No	1	9	8
18	R:R:F196	R:R:F241	45.5619	4.29	Yes	Yes	1	8	9
19	R:R:F196	R:R:H249	91.4481	19.23	Yes	Yes	1	8	8
20	R:R:H249	R:R:Y248	28.7291	4.36	Yes	Yes	1	8	7
21	R:R:Y248	R:R:Y277	28.1451	7.94	Yes	Yes	1	7	5
22	R:R:F245	R:R:I110	54.2238	6.28	Yes	No	1	8	8
23	R:R:F196	R:R:F245	46.1482	4.29	Yes	Yes	1	8	8
24	R:R:H249	R:R:R252	59.4368	5.64	Yes	Yes	1	8	6
25	R:R:R252	R:R:Y277	29.513	8.23	Yes	Yes	1	6	5
26	R:R:F63	R:R:Y48	14.3868	5.16	Yes	Yes	0	6	7
27	R:R:L62	R:R:Y48	54.2693	4.69	Yes	Yes	4	8	7
28	R:R:I116	R:R:L62	27.621	4.28	No	Yes	0	9	8
29	R:R:I116	R:R:R120	28.1217	5.01	No	No	0	9	9
30	R:R:L62	R:R:Y295	31.4683	3.52	Yes	Yes	0	8	9
31	R:R:N59	R:R:Y48	38.5512	10.47	No	Yes	0	7	7
32	R:R:N56	R:R:N59	32.7319	10.9	No	No	0	7	7
33	R:R:N56	R:R:R129	31.5416	7.23	No	Yes	0	7	5
34	R:R:L113	R:R:Y295	12.1827	4.69	No	Yes	0	8	9
35	R:R:L113	R:R:L65	11.5809	5.54	No	Yes	0	8	9
36	R:R:F112	R:R:L65	22.027	2.44	Yes	Yes	3	8	9
37	R:R:F112	R:R:I146	13.0344	6.28	Yes	No	0	8	7
38	R:R:F115	R:R:I146	10.4439	6.28	No	No	0	6	7
39	R:R:L65	R:R:N291	11.572	5.49	Yes	No	3	9	9
40	R:R:C172	R:R:W88	31.4494	10.45	No	Yes	1	9	8
41	R:R:C172	R:R:R99	37.0101	4.18	No	Yes	1	9	6
42	L:L:?1	R:R:R99	34.3463	16.18	Yes	Yes	1	0	6
43	R:R:W88	R:R:Y90	20.0362	11.58	Yes	Yes	1	8	7
44	R:R:F175	R:R:I157	12.9655	6.28	Yes	Yes	1	4	4
45	R:R:F175	R:R:R252	32.2245	6.41	Yes	Yes	1	4	6
46	R:R:F175	R:R:H103	13.9393	4.53	Yes	No	1	4	5
47	R:R:L122	R:R:Y121	11.0102	4.69	No	Yes	2	5	8
48	R:R:H131	R:R:L122	12.1894	3.86	Yes	No	2	4	5
49	R:R:H131	R:R:Q134	25.5824	3.71	Yes	No	2	4	7
50	R:R:Q134	R:R:R129	26.7571	7.01	No	Yes	2	7	5
51	R:R:F175	R:R:N184	11.0624	4.83	Yes	Yes	0	4	3
52	R:R:K229	R:R:P230	11.2767	3.35	No	No	0	7	7
53	R:R:K229	R:R:L233	11.9307	2.82	No	No	0	7	8
54	R:R:F294	R:R:L233	12.5214	2.44	Yes	No	0	7	8
55	R:R:F294	R:R:Y295	15.7147	7.22	Yes	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L26	R:R:Y30	5.86	0	No	Yes	6	8	2	1
R:R:L26	R:R:Y83	5.86	0	No	No	6	5	2	1
R:R:F285	R:R:Y30	9.28	0	No	Yes	7	8	2	1
L:L:?1	R:R:Y30	4.16	1	Yes	Yes	0	8	0	1
R:R:F72	R:R:L102	6.09	0	Yes	Yes	7	7	2	1
R:R:F285	R:R:F72	13.93	0	No	Yes	7	7	2	2
R:R:N98	R:R:T75	5.85	0	No	No	4	6	2	2
R:R:L102	R:R:T75	8.84	1	Yes	No	7	6	1	2
R:R:L79	R:R:N98	4.12	1	No	No	6	4	1	2
R:R:L79	R:R:R99	3.64	1	No	Yes	6	6	1	1
L:L:?1	R:R:L79	3.69	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y83	5.2	1	Yes	No	0	5	0	1
R:R:I161	R:R:R99	7.52	0	No	Yes	4	6	2	1
R:R:C172	R:R:R99	4.18	1	No	Yes	9	6	2	1
L:L:?1	R:R:R99	16.18	1	Yes	Yes	0	6	0	1
R:R:H103	R:R:L102	3.86	1	No	Yes	5	7	1	1
L:L:?1	R:R:L102	7.37	1	Yes	Yes	0	7	0	1
R:R:F175	R:R:H103	4.53	1	Yes	No	4	5	2	1
L:L:?1	R:R:H103	7.99	1	Yes	No	0	5	0	1
R:R:D174	R:R:S177	8.83	1	Yes	No	5	4	1	2
R:R:D174	R:R:Y277	4.6	1	Yes	Yes	5	5	1	2
R:R:D174	R:R:R281	4.76	1	Yes	No	5	6	1	1
L:L:?1	R:R:D174	3.61	1	Yes	Yes	0	5	0	1
R:R:R281	R:R:Y277	17.49	1	No	Yes	6	5	1	2
L:L:?1	R:R:R281	14.02	1	Yes	No	0	6	0	1
R:R:I80	R:R:Y30	2.42	0	No	Yes	6	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WP1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	284
Number of Links	320
Number of Hubs	43
Number of Links mediated by Hubs	167
Number of Communities	9
Number of Nodes involved in Communities	66
Number of Links involved in Communities	88

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	117451
Length Of Smallest Path	3
Average Path Length	19.2027
Length of Longest Path	35
Minimum Path Strength	1.265
Average Path Strength	6.53748
Maximum Path Strength	15.8967
Minimum Path Correlation	0.7
Average Path Correlation	0.926834
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	39.6795
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.7934
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • macrophage activation involved in immune response • immune response • cell activation • cell activation involved in immune response • myeloid cell activation involved in immune response • myeloid leukocyte activation • leukocyte activation • immune effector process • macrophage activation • leukocyte activation involved in immune response • regulation of defense response • regulation of response to external stimulus • defense response • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • response to metal ion • response to calcium ion • chemotaxis • positive regulation of locomotion • regulation of chemotaxis • positive regulation of chemotaxis • taxis • regulation of locomotion • locomotion • regulation of systemic arterial blood pressure by renin-angiotensin • renin secretion into blood stream • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • renal system process • regulation of blood pressure • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • regulation of systemic arterial blood pressure • endocrine process • regulation of protein metabolic process • regulation of macromolecule metabolic process • regulation of angiotensin metabolic process • protein metabolic process • macromolecule metabolic process • multicellular organismal-level homeostasis • homeostatic process • energy homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U9S
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U9S
Name	(2R,3S)-oxirane-2,3-dicarboxylic acid
Synonyms	cis-2,3-epoxysuccinic acid
Identifier
Formula	C4 H4 O5
Molecular Weight	132.072
SMILES
PubChem	2734802
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	2
Total Bonds	13
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXA5
Sequence	>8WP1_nogp_Chain_R A T C K N W L A A E A A L E K Y Y L S I F Y G I E F V V G V L G N T I V V Y G Y I F S L K N W N S S N I Y L F N L S V S D L A F L C T L P M L I R S Y A N G N W I Y G D V L C I S N R Y V L H A N L Y T S I L F L T F I S I D R Y L I I K Y P F R E H L L Q K K E F A I L I S L A I W V L V T L E L L P I L P L I N P V I T D N G T T C N D F A S S G D P N Y N L I Y S M C L T L L G F L I P L F V M C F F Y Y K I A L F L K Q R N R Q V A T A L P L E K P L N L V I M A V V I F S V L F T P Y H V M R N V R I A S R L G S W K Q Y Q C T Q V V I N S F Y I V T R P L A F L N S V I N P V F Y F L L G D H F R D M L M N Q L R H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6Z10	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	PubChem 154585554	-	-	2.27	2020-09-16	doi.org/10.1021/acs.jmedchem.0c01020
	8JPN	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ1	2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPN (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	chim(Gs-CtGq)/β1/γ1	3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8YKW	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ1	2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKW (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-	Gi1/β1/γ1	2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-		2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	6IBB	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	-	-	-	2.12	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	6RNK	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	NF-56-EJ40	-	-	1.94	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	8WOG	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ2	2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WOG (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ2	3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1 (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8YKV	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-	Gi1/β1/γ2	2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKV (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-		2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7

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