psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K12	R:R:T10	9.01	No	No	0	4	9
2	R:R:N13	R:R:T10	5.85	No	No	0	6	9
3	R:R:C11	R:R:C268	7.28	No	No	2	7	1
4	R:R:N13	R:R:W14	6.78	No	No	0	6	5
5	R:R:S275	R:R:W14	3.71	No	No	0	1	5
6	R:R:E18	R:R:V271	9.98	No	No	0	5	2
7	R:R:E18	R:R:S275	4.31	No	No	0	5	1
8	R:R:L21	R:R:Y25	5.86	No	Yes	0	4	4
9	R:R:E22	R:R:Y83	5.61	No	Yes	0	5	5
10	R:R:E22	R:R:I278	4.1	No	Yes	0	5	4
11	R:R:K23	R:R:Y24	14.33	No	No	0	4	3
12	R:R:F29	R:R:Y25	10.32	Yes	Yes	1	5	4
13	R:R:P282	R:R:Y25	5.56	Yes	Yes	1	5	4
14	R:R:L26	R:R:Y30	5.86	Yes	Yes	1	6	8
15	R:R:L26	R:R:Y83	4.69	Yes	Yes	1	6	5
16	R:R:I278	R:R:L26	4.28	Yes	Yes	1	4	6
17	R:R:L26	R:R:R281	4.86	Yes	Yes	1	6	6
18	R:R:F29	R:R:I32	5.02	Yes	No	0	5	6
19	R:R:E33	R:R:F29	12.83	No	Yes	0	7	5
20	R:R:F29	R:R:P282	8.67	Yes	Yes	1	5	5
21	R:R:I80	R:R:Y30	4.84	Yes	Yes	0	6	8
22	R:R:F285	R:R:Y30	7.22	Yes	Yes	1	7	8
23	L:L:?1	R:R:Y30	5.81	Yes	Yes	1	0	8
24	R:R:E33	R:R:L286	6.63	No	No	0	7	5
25	R:R:F34	R:R:V38	3.93	No	No	0	7	6
26	R:R:F34	R:R:P77	14.45	No	No	0	7	8
27	R:R:G37	R:R:L73	5.13	No	No	0	8	6
28	R:R:G37	R:R:V289	3.68	No	No	0	8	8
29	R:R:G40	R:R:L39	5.13	No	No	0	8	4
30	R:R:D69	R:R:N41	6.73	Yes	No	0	9	9
31	R:R:L70	R:R:N41	5.49	No	No	0	8	9
32	R:R:N41	R:R:P292	6.52	No	No	0	9	9
33	R:R:F296	R:R:V44	13.11	Yes	No	0	6	9
34	R:R:Q309	R:R:Y46	6.76	No	No	0	5	4
35	R:R:L310	R:R:Y46	3.52	No	No	0	6	4
36	R:R:G47	R:R:S51	3.71	No	No	0	7	5
37	R:R:W55	R:R:Y48	3.86	No	Yes	4	6	7
38	R:R:N59	R:R:Y48	12.79	No	Yes	0	7	7
39	R:R:L62	R:R:Y48	4.69	No	Yes	4	8	7
40	R:R:F63	R:R:Y48	6.19	Yes	Yes	4	6	7
41	R:R:F296	R:R:Y48	7.22	Yes	Yes	4	6	7
42	R:R:F50	R:R:I49	10.05	No	No	0	4	4
43	R:R:M305	R:R:S51	4.6	No	No	0	4	5
44	R:R:Q309	R:R:S51	12.99	No	No	0	5	5
45	R:R:I60	R:R:W55	3.52	Yes	No	0	7	6
46	R:R:F63	R:R:W55	8.02	Yes	No	4	6	6
47	R:R:N56	R:R:N59	10.9	No	No	0	7	7
48	R:R:N56	R:R:R129	12.05	No	No	0	7	5
49	R:R:D119	R:R:S57	5.89	No	No	0	8	6
50	R:R:D119	R:R:S58	8.83	No	No	0	8	8
51	R:R:A139	R:R:I60	4.87	No	Yes	0	7	7
52	R:R:F115	R:R:Y61	4.13	No	Yes	5	6	7
53	R:R:D119	R:R:Y61	6.9	No	Yes	0	8	7
54	R:R:A139	R:R:Y61	4	No	Yes	0	7	7
55	R:R:I142	R:R:Y61	7.25	No	Yes	5	5	7
56	R:R:L62	R:R:Y295	3.52	No	Yes	0	8	9
57	R:R:F296	R:R:L62	12.18	Yes	No	4	6	8
58	R:R:F63	R:R:V67	5.24	Yes	No	0	6	7
59	R:R:F112	R:R:N64	13.29	Yes	No	3	8	9
60	R:R:N64	R:R:S143	10.43	No	No	3	9	7
61	R:R:N64	R:R:W147	4.52	No	Yes	3	9	9
62	R:R:D69	R:R:L65	5.43	Yes	No	0	9	9
63	R:R:L113	R:R:L65	5.54	No	No	0	8	9
64	R:R:I116	R:R:L65	4.28	No	No	0	9	9
65	R:R:S68	R:R:T108	4.8	No	No	3	8	7
66	R:R:S68	R:R:W147	7.41	No	Yes	3	8	9
67	R:R:D69	R:R:S109	4.42	Yes	No	0	9	9
68	R:R:D69	R:R:S288	8.83	Yes	No	0	9	9
69	R:R:D69	R:R:N291	6.73	Yes	No	0	9	9
70	R:R:A71	R:R:N105	4.69	No	No	0	6	8
71	R:R:F72	R:R:L102	10.96	Yes	Yes	1	7	7
72	R:R:F72	R:R:N105	3.62	Yes	No	0	7	8
73	R:R:F285	R:R:F72	12.86	Yes	Yes	1	7	7
74	R:R:F72	R:R:S288	7.93	Yes	No	0	7	9
75	R:R:L73	R:R:S288	4.5	No	No	0	6	9
76	R:R:N98	R:R:T75	11.7	No	No	0	4	6
77	R:R:L102	R:R:T75	5.9	Yes	No	0	7	6
78	R:R:M78	R:R:W88	4.65	No	Yes	6	7	8
79	R:R:M78	R:R:Y90	7.18	No	Yes	6	7	7
80	R:R:L79	R:R:Y83	3.52	No	Yes	1	6	5
81	L:L:?1	R:R:L79	4.11	Yes	No	1	0	6
82	R:R:N85	R:R:R81	15.67	No	No	0	3	5
83	R:R:S82	R:R:W88	9.88	No	Yes	0	5	8
84	L:L:?1	R:R:Y83	9.29	Yes	Yes	1	0	5
85	R:R:W88	R:R:Y90	13.5	Yes	Yes	6	8	7
86	R:R:C95	R:R:W88	10.45	No	Yes	0	9	8
87	R:R:I89	R:R:Y90	13.3	No	Yes	0	3	7
88	R:R:D92	R:R:P163	17.71	No	No	0	2	5
89	R:R:D92	R:R:T170	10.12	No	No	0	2	5
90	R:R:C172	R:R:C95	7.28	No	No	0	9	9
91	R:R:H103	R:R:R99	4.51	Yes	No	1	5	6
92	R:R:I161	R:R:R99	6.26	Yes	No	0	4	6
93	L:L:?1	R:R:R99	7.22	Yes	No	1	0	6
94	R:R:T151	R:R:Y100	3.75	No	Yes	0	4	6
95	R:R:L154	R:R:Y100	3.52	No	Yes	0	7	6
96	R:R:L155	R:R:Y100	4.69	No	Yes	0	4	6
97	R:R:L158	R:R:Y100	5.86	No	Yes	0	4	6
98	R:R:H103	R:R:L102	3.86	Yes	Yes	1	5	7
99	R:R:F285	R:R:L102	4.87	Yes	Yes	1	7	7
100	L:L:?1	R:R:L102	4.11	Yes	Yes	1	0	7
101	R:R:H103	R:R:L154	3.86	Yes	No	0	5	7
102	R:R:H103	R:R:I157	3.98	Yes	Yes	1	5	4
103	R:R:F175	R:R:H103	4.53	Yes	Yes	1	4	5
104	L:L:?1	R:R:H103	7.64	Yes	Yes	1	0	5
105	R:R:F245	R:R:L106	3.65	Yes	No	0	8	8
106	R:R:L154	R:R:Y107	3.52	No	Yes	0	7	7
107	R:R:L191	R:R:Y107	14.07	No	Yes	1	5	7
108	R:R:H249	R:R:Y107	4.36	Yes	Yes	1	8	7
109	R:R:R252	R:R:Y107	4.12	Yes	Yes	1	6	7
110	R:R:T108	R:R:W147	4.85	No	Yes	3	7	9
111	R:R:T108	R:R:V150	7.93	No	No	0	7	8
112	R:R:I110	R:R:P199	3.39	No	No	0	8	8
113	R:R:F241	R:R:I110	5.02	Yes	No	1	9	8
114	R:R:F245	R:R:I110	7.54	Yes	No	1	8	8
115	R:R:I146	R:R:L111	7.14	No	No	0	7	6
116	R:R:F112	R:R:S143	6.61	Yes	No	3	8	7
117	R:R:F112	R:R:I146	8.79	Yes	No	0	8	7
118	R:R:F112	R:R:W147	7.02	Yes	Yes	3	8	9
119	R:R:L113	R:R:Y295	4.69	No	Yes	0	8	9
120	R:R:P199	R:R:T114	5.25	No	No	0	8	7
121	R:R:F115	R:R:I142	11.3	No	No	5	6	5
122	R:R:F115	R:R:I146	6.28	No	No	0	6	7
123	R:R:M203	R:R:S117	4.6	No	No	1	8	9
124	R:R:S117	R:R:Y207	6.36	No	Yes	1	9	9
125	R:R:F206	R:R:I118	7.54	No	No	0	8	6
126	R:R:R120	R:R:Y207	8.23	No	Yes	0	9	9
127	R:R:R120	R:R:Y295	6.17	No	Yes	0	9	9
128	R:R:K125	R:R:Y121	9.55	No	Yes	0	7	8
129	R:R:F206	R:R:Y121	9.28	No	Yes	0	8	8
130	R:R:K209	R:R:Y121	9.55	No	Yes	0	4	8
131	R:R:I210	R:R:Y121	4.84	No	Yes	0	8	8
132	R:R:L122	R:R:Q134	3.99	No	Yes	0	5	7
133	R:R:I123	R:R:R129	7.52	No	No	0	8	5
134	R:R:F213	R:R:I124	7.54	No	No	0	5	8
135	R:R:K125	R:R:Y126	3.58	No	Yes	0	7	6
136	R:R:F213	R:R:K125	4.96	No	No	0	5	7
137	R:R:E130	R:R:Y126	5.61	No	Yes	0	5	6
138	R:R:H131	R:R:Y126	14.16	Yes	Yes	7	4	6
139	R:R:Q134	R:R:Y126	5.64	Yes	Yes	7	7	6
140	R:R:E130	R:R:F128	9.33	No	No	0	5	5
141	R:R:Q134	R:R:R129	7.01	Yes	No	0	7	5
142	R:R:H131	R:R:L133	3.86	Yes	No	0	4	3
143	R:R:H131	R:R:Q134	6.18	Yes	Yes	7	4	7
144	R:R:E137	R:R:K135	12.15	No	No	0	3	6
145	R:R:L152	R:R:L155	4.15	No	No	0	4	4
146	R:R:E153	R:R:L194	6.63	No	No	0	5	5
147	R:R:P156	R:R:Y187	8.34	No	Yes	0	8	5
148	R:R:I157	R:R:I161	5.89	Yes	Yes	0	4	4
149	R:R:F175	R:R:I157	5.02	Yes	Yes	1	4	4
150	R:R:I157	R:R:Y187	3.63	Yes	Yes	1	4	5
151	R:R:P159	R:R:Y183	4.17	No	No	0	4	2
152	R:R:L160	R:R:Y183	9.38	No	No	0	5	2
153	R:R:L160	R:R:N184	9.61	No	No	0	5	3
154	R:R:L160	R:R:Y187	3.52	No	Yes	0	5	5
155	R:R:N162	R:R:P163	4.89	No	No	0	4	5
156	R:R:T171	R:R:V164	4.76	No	No	0	3	1
157	R:R:D167	R:R:T166	11.56	No	No	0	4	1
158	R:R:N173	R:R:S178	5.96	No	No	0	4	3
159	R:R:D174	R:R:S177	8.83	No	No	0	5	4
160	L:L:?1	R:R:D174	5.38	Yes	No	0	0	5
161	R:R:F175	R:R:N184	7.25	Yes	No	0	4	3
162	R:R:F175	R:R:Y187	4.13	Yes	Yes	1	4	5
163	R:R:F175	R:R:R252	4.28	Yes	Yes	1	4	6
164	R:R:A176	R:R:Y277	5.34	No	Yes	0	6	5
165	R:R:R255	R:R:S177	6.59	Yes	No	0	5	4
166	R:R:D180	R:R:P181	6.44	No	No	0	3	1
167	R:R:D180	R:R:N182	6.73	No	No	0	3	1
168	R:R:L260	R:R:N182	6.87	No	No	0	1	1
169	R:R:I256	R:R:N184	9.91	No	No	0	5	3
170	R:R:I256	R:R:L185	7.14	No	No	0	5	4
171	R:R:L191	R:R:Y187	3.52	No	Yes	1	5	5
172	R:R:R252	R:R:S188	7.91	Yes	No	0	6	5
173	R:R:N253	R:R:S188	4.47	No	No	0	6	5
174	R:R:M189	R:R:N253	9.82	No	No	0	5	6
175	R:R:L191	R:R:R252	3.64	No	Yes	1	5	6
176	R:R:H249	R:R:T192	5.48	Yes	No	0	8	6
177	R:R:N253	R:R:T192	7.31	No	No	0	6	6
178	R:R:L193	R:R:L197	4.15	No	No	0	5	4
179	R:R:F196	R:R:L197	3.65	Yes	No	0	8	4
180	R:R:F196	R:R:F241	4.29	Yes	Yes	1	8	9
181	R:R:F196	R:R:F245	4.29	Yes	Yes	1	8	8
182	R:R:F196	R:R:T246	3.89	Yes	Yes	0	8	5
183	R:R:F196	R:R:H249	18.1	Yes	Yes	1	8	8
184	R:R:I198	R:R:P199	5.08	No	No	0	6	8
185	R:R:F241	R:R:L200	4.87	Yes	No	0	9	6
186	R:R:M203	R:R:Y207	4.79	No	Yes	1	8	9
187	R:R:F241	R:R:M203	7.46	Yes	No	1	9	8
188	R:R:F205	R:R:K209	13.65	No	No	0	4	4
189	R:R:V234	R:R:Y207	8.83	No	Yes	0	8	9
190	R:R:A237	R:R:Y207	4	No	Yes	0	8	9
191	R:R:V238	R:R:Y207	5.05	No	Yes	0	8	9
192	R:R:Q216	R:R:Q220	3.84	No	No	0	5	2
193	R:R:Q220	R:R:R217	4.67	No	No	0	2	5
194	R:R:N218	R:R:P226	4.89	No	No	0	4	5
195	R:R:Q220	R:R:R219	8.18	No	No	0	2	4
196	R:R:E228	R:R:P226	11	No	No	0	5	5
197	R:R:M236	R:R:V239	4.56	No	No	0	5	5
198	R:R:F294	R:R:I240	3.77	Yes	No	0	7	7
199	R:R:F241	R:R:F245	7.5	Yes	Yes	1	9	8
200	R:R:L244	R:R:N287	12.36	No	No	0	9	9
201	R:R:F245	R:R:N287	13.29	Yes	No	0	8	9
202	R:R:P247	R:R:T246	3.5	No	Yes	0	9	5
203	R:R:H249	R:R:Y248	4.36	Yes	Yes	1	8	7
204	R:R:R252	R:R:Y248	6.17	Yes	Yes	1	6	7
205	R:R:Y248	R:R:Y277	7.94	Yes	Yes	1	7	5
206	R:R:A284	R:R:Y248	4	No	Yes	0	8	7
207	R:R:H249	R:R:R252	5.64	Yes	Yes	1	8	6
208	R:R:F276	R:R:M251	3.73	No	No	0	5	4
209	R:R:R252	R:R:Y277	6.17	Yes	Yes	1	6	5
210	R:R:I273	R:R:V254	4.61	No	No	0	5	5
211	R:R:R255	R:R:R259	7.46	Yes	No	0	5	3
212	R:R:N274	R:R:R255	16.87	No	Yes	0	3	5
213	R:R:R255	R:R:Y277	5.14	Yes	Yes	0	5	5
214	R:R:Q270	R:R:S258	5.78	No	No	0	3	2
215	R:R:I273	R:R:S258	6.19	No	No	0	5	2
216	R:R:K264	R:R:W263	3.48	No	No	0	3	1
217	R:R:K264	R:R:Y266	13.14	No	No	2	3	5
218	R:R:K264	R:R:T269	6.01	No	No	2	3	1
219	R:R:C268	R:R:Y266	5.38	No	No	2	1	5
220	R:R:T269	R:R:Y266	11.24	No	No	2	1	5
221	R:R:I278	R:R:N274	5.66	Yes	No	0	4	3
222	R:R:R281	R:R:Y277	13.38	Yes	Yes	1	6	5
223	R:R:I278	R:R:R281	6.26	Yes	Yes	1	4	6
224	L:L:?1	R:R:R281	13.24	Yes	Yes	1	0	6
225	L:L:?1	R:R:F285	3.62	Yes	Yes	1	0	7
226	R:R:I290	R:R:L286	5.71	No	No	0	6	5
227	R:R:N291	R:R:Y295	5.81	No	Yes	0	9	9
228	R:R:F294	R:R:Y295	5.16	Yes	Yes	0	7	9
229	R:R:F296	R:R:F302	5.36	Yes	No	0	6	8
230	R:R:D300	R:R:H301	10.08	Yes	No	0	5	6
231	R:R:L306	R:R:L310	4.15	No	No	0	7	6
232	R:R:N308	R:R:R311	4.82	No	No	0	4	5
233	R:R:N313	R:R:Q309	5.28	No	No	0	2	5
234	R:R:H312	R:R:N313	20.41	No	No	0	3	2
235	R:R:F314	R:R:T318	10.38	No	No	0	2	6
236	R:R:L317	R:R:S316	4.5	No	No	0	3	7
237	R:R:K229	R:R:P230	3.35	No	No	0	7	7
238	R:R:L26	R:R:P282	3.28	Yes	Yes	1	6	5
239	R:R:L214	R:R:P230	3.28	No	No	0	7	7
240	R:R:L227	R:R:P230	3.28	No	No	0	6	7
241	R:R:S66	R:R:V45	3.23	No	No	0	9	8
242	R:R:S242	R:R:V243	3.23	No	No	0	6	6
243	R:R:F213	R:R:R217	3.21	No	No	0	5	5
244	R:R:T75	R:R:V101	3.17	No	No	0	6	5
245	R:R:T114	R:R:V202	3.17	No	No	0	7	7
246	R:R:T166	R:R:V164	3.17	No	No	0	1	1
247	R:R:C204	R:R:L200	3.17	No	No	0	5	6
248	R:R:T280	R:R:V279	3.17	No	No	0	7	5
249	R:R:I80	R:R:S27	3.1	Yes	No	0	6	5
250	R:R:I161	R:R:S178	3.1	Yes	No	0	4	3
251	R:R:R81	R:R:Y90	3.09	No	Yes	0	5	7
252	R:R:L297	R:R:V293	2.98	No	No	0	7	6
253	R:R:I60	R:R:K136	2.91	Yes	No	0	7	1
254	R:R:G195	R:R:Y107	2.9	No	Yes	0	6	7
255	R:R:F128	R:R:P127	2.89	No	No	0	5	8
256	R:R:P181	R:R:R259	2.88	No	No	0	1	3
257	R:R:I80	R:R:L76	2.85	Yes	No	0	6	8
258	R:R:I210	R:R:L214	2.85	No	No	0	8	7
259	R:R:I235	R:R:L231	2.85	No	No	0	4	6
260	R:R:L52	R:R:M305	2.83	No	No	0	5	4
261	R:R:Q270	R:R:T269	2.83	No	No	0	3	1
262	R:R:K229	R:R:L233	2.82	No	No	0	7	8
263	R:R:K53	R:R:N54	2.8	No	No	0	5	6
264	R:R:L193	R:R:L194	2.77	No	No	0	5	5
265	R:R:L52	R:R:N59	2.75	No	No	0	5	7
266	R:R:N13	R:R:N8	2.72	No	No	0	6	9
267	R:R:F63	R:R:S66	2.64	Yes	No	0	6	9
268	R:R:F296	R:R:S66	2.64	Yes	No	0	6	9
269	R:R:A257	R:R:W263	2.59	No	No	0	4	1
270	R:R:V279	R:R:Y25	2.52	No	Yes	0	5	4
271	R:R:F63	R:R:I49	2.51	Yes	No	0	6	4
272	R:R:F294	R:R:M236	2.49	Yes	No	0	7	5
273	R:R:F34	R:R:L76	2.44	No	No	0	7	8
274	R:R:F294	R:R:L298	2.44	Yes	No	0	7	6
275	R:R:F302	R:R:L297	2.44	No	No	0	8	7
276	R:R:I186	R:R:Y183	2.42	No	No	0	4	2
277	R:R:L94	R:R:Y90	2.34	No	Yes	0	6	7
278	R:R:L212	R:R:Y208	2.34	No	No	0	3	3
279	R:R:G40	R:R:P292	2.03	No	No	0	8	9
280	R:R:G179	R:R:S178	1.86	No	No	0	1	3
281	R:R:G37	R:R:V36	1.84	No	No	0	8	6
282	R:R:G31	R:R:I80	1.76	No	Yes	0	5	6
283	R:R:G40	R:R:I43	1.76	No	No	0	8	6
284	R:R:G86	R:R:K23	1.74	No	No	0	4	4
285	R:R:C11	R:R:V271	1.71	No	No	2	7	2
286	R:R:A84	R:R:S27	1.71	No	No	0	5	5
287	R:R:G91	R:R:L94	1.71	No	No	0	8	6
288	R:R:C268	R:R:V271	1.71	No	No	2	1	2
289	R:R:G86	R:R:N87	1.7	No	No	0	4	4
290	R:R:A104	R:R:V150	1.7	No	No	0	5	8
291	R:R:A211	R:R:V234	1.7	No	No	0	5	8
292	R:R:A224	R:R:V221	1.7	No	No	0	2	3
293	R:R:I96	R:R:P163	1.69	No	No	0	7	5
294	R:R:D300	R:R:G299	1.68	Yes	No	0	5	8
295	R:R:C95	R:R:I96	1.64	No	No	0	9	7
296	R:R:L225	R:R:P226	1.64	No	No	0	3	5
297	R:R:L283	R:R:P282	1.64	No	Yes	0	7	5
298	R:R:S97	R:R:V101	1.62	No	No	0	5	5
299	R:R:V239	R:R:V243	1.6	No	No	0	5	6
300	R:R:S242	R:R:T246	1.6	No	Yes	0	6	5
301	R:R:T246	R:R:V250	1.59	Yes	No	0	5	7
302	R:R:A17	R:R:L21	1.58	No	No	0	2	4
303	R:R:A257	R:R:L185	1.58	No	No	0	4	4
304	R:R:A211	R:R:L231	1.58	No	No	0	5	6
305	R:R:I273	R:R:V272	1.54	No	No	0	5	3
306	R:R:I43	R:R:T42	1.52	No	No	0	6	4
307	R:R:I165	R:R:T170	1.52	No	No	0	1	5
308	R:R:M251	R:R:T280	1.51	No	No	0	4	7
309	R:R:L39	R:R:V35	1.49	No	No	0	4	4
310	R:R:N218	R:R:V221	1.48	No	No	0	4	3
311	R:R:I140	R:R:I60	1.47	No	Yes	0	4	7
312	R:R:I161	R:R:I96	1.47	Yes	No	0	4	7
313	R:R:K215	R:R:L212	1.41	No	No	0	4	3
314	R:R:K215	R:R:L231	1.41	No	No	0	4	6
315	R:R:M307	R:R:N308	1.4	No	No	0	4	4
316	R:R:L227	R:R:N218	1.37	No	No	0	6	4
317	R:R:N85	R:R:N87	1.36	No	No	0	3	4
318	R:R:E137	R:R:K136	1.35	No	No	0	3	1
319	R:R:D300	R:R:D304	1.33	Yes	No	8	5	4
320	R:R:H131	R:R:L132	1.29	Yes	No	0	4	4
321	R:R:F138	R:R:K135	1.24	No	No	0	4	6
322	R:R:M307	R:R:R303	1.24	No	No	0	4	8
323	R:R:D300	R:R:R303	1.19	Yes	No	8	5	8
324	R:R:D304	R:R:R303	1.19	No	No	8	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y25	6.065	4	1	4
2	R:R:L26	4.594	5	1	6
3	R:R:F29	9.21	4	1	5
4	R:R:Y30	5.9325	4	1	8
5	R:R:Y48	6.95	5	4	7
6	R:R:I60	3.1925	4	0	7
7	R:R:Y61	5.57	4	5	7
8	R:R:F63	4.92	5	4	6
9	R:R:D69	6.428	5	0	9
10	R:R:F72	8.8425	4	1	7
11	R:R:I80	3.1375	4	0	6
12	R:R:Y83	5.7775	4	1	5
13	R:R:W88	9.62	4	6	8
14	R:R:Y90	7.882	5	6	7
15	R:R:Y100	4.455	4	0	6
16	R:R:L102	5.94	5	1	7
17	R:R:H103	4.73	6	1	5
18	R:R:Y107	5.794	5	1	7
19	R:R:F112	8.9275	4	3	8
20	R:R:Y121	8.305	4	0	8
21	R:R:Y126	7.2475	4	7	6
22	R:R:H131	6.3725	4	7	4
23	R:R:Q134	5.705	4	7	7
24	R:R:W147	5.95	4	3	9
25	R:R:I157	4.63	4	1	4
26	R:R:I161	4.18	4	0	4
27	R:R:F175	5.042	5	1	4
28	R:R:Y187	4.628	5	1	5
29	R:R:F196	6.844	5	1	8
30	R:R:Y207	6.21	6	1	9
31	R:R:F241	5.828	5	1	9
32	R:R:F245	7.254	5	1	8
33	R:R:T246	2.645	4	0	5
34	R:R:Y248	5.6175	4	1	7
35	R:R:H249	7.588	5	1	8
36	R:R:R252	5.41857	7	1	6
37	R:R:R255	9.015	4	0	5
38	R:R:Y277	7.594	5	1	5
39	R:R:I278	5.075	4	1	4
40	R:R:R281	9.435	4	1	6
41	R:R:P282	4.7875	4	1	5
42	R:R:F285	7.1425	4	1	7
43	R:R:F294	3.465	4	0	7
44	R:R:Y295	5.07	5	0	9
45	R:R:F296	8.102	5	4	6
46	R:R:D300	3.57	4	8	5
47	L:L:?1	6.71333	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C268	R:R:Y266	11.653	5.38	No	No	2	1	5
2	R:R:K264	R:R:Y266	12.5417	13.14	No	No	2	3	5
3	R:R:K264	R:R:W263	20.5103	3.48	No	No	0	3	1
4	R:R:A257	R:R:W263	21.5841	2.59	No	No	0	4	1
5	R:R:A257	R:R:L185	22.6505	1.58	No	No	0	4	4
6	R:R:I256	R:R:L185	23.7095	7.14	No	No	0	5	4
7	R:R:I256	R:R:N184	24.7612	9.91	No	No	0	5	3
8	R:R:F175	R:R:N184	29.1343	7.25	Yes	No	0	4	3
9	R:R:F175	R:R:H103	28.0419	4.53	Yes	Yes	1	4	5
10	L:L:?1	R:R:H103	15.2929	7.64	Yes	Yes	1	0	5
11	L:L:?1	R:R:Y30	12.5824	5.81	Yes	Yes	1	0	8
12	R:R:L26	R:R:Y30	15.3781	5.86	Yes	Yes	1	6	8
13	R:R:L26	R:R:P282	27.4643	3.28	Yes	Yes	1	6	5
14	R:R:P282	R:R:Y25	13.7821	5.56	Yes	Yes	1	5	4
15	L:L:?1	R:R:R281	19.8437	13.24	Yes	Yes	1	0	6
16	R:R:L26	R:R:R281	15.4336	4.86	Yes	Yes	1	6	6
17	R:R:F175	R:R:R252	20.1474	4.28	Yes	Yes	1	4	6
18	R:R:R252	R:R:Y277	16.4038	6.17	Yes	Yes	1	6	5
19	R:R:R281	R:R:Y277	24.2465	13.38	Yes	Yes	1	6	5
20	R:R:I157	R:R:I161	20.3918	5.89	Yes	Yes	0	4	4
21	R:R:I161	R:R:I96	51.1627	1.47	Yes	No	0	4	7
22	R:R:C95	R:R:I96	36.877	1.64	No	No	0	9	7
23	R:R:C95	R:R:W88	32.0558	10.45	No	Yes	0	9	8
24	R:R:W88	R:R:Y90	24.7315	13.5	Yes	Yes	6	8	7
25	R:R:R81	R:R:Y90	14.9485	3.09	No	Yes	0	5	7
26	R:R:N85	R:R:R81	12.475	15.67	No	No	0	3	5
27	R:R:I80	R:R:Y30	14.0969	4.84	Yes	Yes	0	6	8
28	R:R:H103	R:R:L102	46.5156	3.86	Yes	Yes	1	5	7
29	L:L:?1	R:R:F285	21.2508	3.62	Yes	Yes	1	0	7
30	R:R:F72	R:R:S288	95.5899	7.93	Yes	No	0	7	9
31	R:R:F72	R:R:L102	65.5595	10.96	Yes	Yes	1	7	7
32	R:R:D69	R:R:N41	11.5789	6.73	Yes	No	0	9	9
33	R:R:D69	R:R:S288	92.9053	8.83	Yes	No	0	9	9
34	R:R:L62	R:R:Y295	100	3.52	No	Yes	0	8	9
35	R:R:N291	R:R:Y295	84.8811	5.81	No	Yes	0	9	9
36	R:R:D69	R:R:N291	85.3625	6.73	Yes	No	0	9	9
37	R:R:L62	R:R:Y48	90.7058	4.69	No	Yes	4	8	7
38	R:R:N59	R:R:Y48	62.6416	12.79	No	Yes	0	7	7
39	R:R:L52	R:R:N59	14.7523	2.75	No	No	0	5	7
40	R:R:L52	R:R:M305	13.3267	2.83	No	No	0	5	4
41	R:R:M305	R:R:S51	11.8751	4.6	No	No	0	4	5
42	R:R:W55	R:R:Y48	33.4222	3.86	No	Yes	4	6	7
43	R:R:I60	R:R:W55	32.6224	3.52	Yes	No	0	7	6
44	R:R:N56	R:R:N59	49.3631	10.9	No	No	0	7	7
45	R:R:N56	R:R:R129	48.1004	12.05	No	No	0	7	5
46	R:R:A139	R:R:Y61	23.0838	4	No	Yes	0	7	7
47	R:R:A139	R:R:I60	24.4686	4.87	No	Yes	0	7	7
48	R:R:F115	R:R:Y61	16.0853	4.13	No	Yes	5	6	7
49	R:R:F112	R:R:I146	11.8159	8.79	Yes	No	0	8	7
50	R:R:F115	R:R:I146	14.6967	6.28	No	No	0	6	7
51	R:R:I96	R:R:P163	12.475	1.69	No	No	0	7	5
52	R:R:H103	R:R:R99	12.6268	4.51	Yes	No	1	5	6
53	R:R:H103	R:R:L154	10.3496	3.86	Yes	No	0	5	7
54	R:R:F196	R:R:H249	44.005	18.1	Yes	Yes	1	8	8
55	R:R:H249	R:R:R252	25.9091	5.64	Yes	Yes	1	8	6
56	R:R:F196	R:R:F241	28.7418	4.29	Yes	Yes	1	8	9
57	R:R:F241	R:R:M203	26.4608	7.46	Yes	No	1	9	8
58	R:R:M203	R:R:Y207	24.9981	4.79	No	Yes	1	8	9
59	R:R:K125	R:R:Y121	24.4872	9.55	No	Yes	0	7	8
60	R:R:K125	R:R:Y126	33.9295	3.58	No	Yes	0	7	6
61	R:R:Q134	R:R:Y126	38.9062	5.64	Yes	Yes	7	7	6
62	R:R:Q134	R:R:R129	45.6602	7.01	Yes	No	0	7	5
63	R:R:R120	R:R:Y207	23.28	8.23	No	Yes	0	9	9
64	R:R:I210	R:R:Y121	17.4517	4.84	No	Yes	0	8	8
65	R:R:R255	R:R:Y277	15.7669	5.14	Yes	Yes	0	5	5
66	R:R:D180	R:R:P181	10.4829	6.44	No	No	0	3	1
67	R:R:P181	R:R:R259	13.9636	2.88	No	No	0	1	3
68	R:R:R255	R:R:R259	17.4369	7.46	Yes	No	0	5	3
69	R:R:I210	R:R:L214	16.0224	2.85	No	No	0	8	7
70	R:R:L214	R:R:P230	14.5819	3.28	No	No	0	7	7
71	R:R:L227	R:R:P230	10.3199	3.28	No	No	0	6	7
72	R:R:I161	R:R:R99	40.2022	6.26	Yes	No	0	4	6
73	L:L:?1	R:R:R99	29.5601	7.22	Yes	No	1	0	6
74	R:R:F285	R:R:Y30	11.69	7.22	Yes	Yes	1	7	8
75	R:R:F285	R:R:F72	32.004	12.86	Yes	Yes	1	7	7
76	L:L:?1	R:R:L102	22.3284	4.11	Yes	Yes	1	0	7
77	R:R:H103	R:R:I157	16.6482	3.98	Yes	Yes	1	5	4
78	R:R:H249	R:R:Y248	11.3049	4.36	Yes	Yes	1	8	7
79	R:R:Y248	R:R:Y277	10.9642	7.94	Yes	Yes	1	7	5
80	R:R:R120	R:R:Y295	23.7132	6.17	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E22	R:R:Y83	5.61	0	No	Yes	5	5	2	1
R:R:E22	R:R:I278	4.1	0	No	Yes	5	4	2	2
R:R:L26	R:R:Y30	5.86	1	Yes	Yes	6	8	2	1
R:R:L26	R:R:Y83	4.69	1	Yes	Yes	6	5	2	1
R:R:I278	R:R:L26	4.28	1	Yes	Yes	4	6	2	2
R:R:L26	R:R:R281	4.86	1	Yes	Yes	6	6	2	1
R:R:I80	R:R:Y30	4.84	0	Yes	Yes	6	8	2	1
R:R:F285	R:R:Y30	7.22	1	Yes	Yes	7	8	1	1
L:L:?1	R:R:Y30	5.81	1	Yes	Yes	0	8	0	1
R:R:F72	R:R:L102	10.96	1	Yes	Yes	7	7	2	1
R:R:F285	R:R:F72	12.86	1	Yes	Yes	7	7	1	2
R:R:L102	R:R:T75	5.9	1	Yes	No	7	6	1	2
R:R:L79	R:R:Y83	3.52	1	No	Yes	6	5	1	1
L:L:?1	R:R:L79	4.11	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y83	9.29	1	Yes	Yes	0	5	0	1
R:R:H103	R:R:R99	4.51	1	Yes	No	5	6	1	1
R:R:I161	R:R:R99	6.26	0	Yes	No	4	6	2	1
L:L:?1	R:R:R99	7.22	1	Yes	No	0	6	0	1
R:R:H103	R:R:L102	3.86	1	Yes	Yes	5	7	1	1
R:R:F285	R:R:L102	4.87	1	Yes	Yes	7	7	1	1
L:L:?1	R:R:L102	4.11	1	Yes	Yes	0	7	0	1
R:R:H103	R:R:L154	3.86	1	Yes	No	5	7	1	2
R:R:H103	R:R:I157	3.98	1	Yes	Yes	5	4	1	2
R:R:F175	R:R:H103	4.53	1	Yes	Yes	4	5	2	1
L:L:?1	R:R:H103	7.64	1	Yes	Yes	0	5	0	1
R:R:I157	R:R:I161	5.89	1	Yes	Yes	4	4	2	2
R:R:F175	R:R:I157	5.02	1	Yes	Yes	4	4	2	2
R:R:D174	R:R:S177	8.83	0	No	No	5	4	1	2
L:L:?1	R:R:D174	5.38	1	Yes	No	0	5	0	1
R:R:R281	R:R:Y277	13.38	1	Yes	Yes	6	5	1	2
R:R:I278	R:R:R281	6.26	1	Yes	Yes	4	6	2	1
L:L:?1	R:R:R281	13.24	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F285	3.62	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WOG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	287
Number of Links	324
Number of Hubs	47
Number of Links mediated by Hubs	166
Number of Communities	8
Number of Nodes involved in Communities	60
Number of Links involved in Communities	84

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	62081
Length Of Smallest Path	3
Average Path Length	14.3641
Length of Longest Path	39
Minimum Path Strength	1.215
Average Path Strength	6.33855
Maximum Path Strength	13.915
Minimum Path Correlation	0.7
Average Path Correlation	0.935947
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	51.6602
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.7678
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • macrophage activation involved in immune response • immune response • cell activation • cell activation involved in immune response • myeloid cell activation involved in immune response • myeloid leukocyte activation • leukocyte activation • immune effector process • macrophage activation • leukocyte activation involved in immune response • regulation of defense response • regulation of response to external stimulus • defense response • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • response to metal ion • response to calcium ion • chemotaxis • positive regulation of locomotion • regulation of chemotaxis • positive regulation of chemotaxis • taxis • regulation of locomotion • locomotion • regulation of systemic arterial blood pressure by renin-angiotensin • renin secretion into blood stream • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • renal system process involved in regulation of systemic arterial blood pressure • blood circulation • renal system process • regulation of blood pressure • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • regulation of systemic arterial blood pressure • endocrine process • regulation of protein metabolic process • regulation of macromolecule metabolic process • regulation of angiotensin metabolic process • protein metabolic process • macromolecule metabolic process • multicellular organismal-level homeostasis • homeostatic process • energy homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SIN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SIN
Name	Succinic acid
Synonyms	Acidum succinicum
Identifier
Formula	C4 H6 O4
Molecular Weight	118.088
SMILES
PubChem	1110
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	13
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXA5
Sequence	>8WOG_nogp_Chain_R N A T C K N W L A A E A A L E K Y Y L S I F Y G I E F V V G V L G N T I V V Y G Y I F S L K N W N S S N I Y L F N L S V S D L A F L C T L P M L I R S Y A N G N W I Y G D V L C I S N R Y V L H A N L Y T S I L F L T F I S I D R Y L I I K Y P F R E H L L Q K K E F A I L I S L A I W V L V T L E L L P I L P L I N P V I T D N G T T C N D F A S S G D P N Y N L I Y S M C L T L L G F L I P L F V M C F F Y Y K I A L F L K Q R N R Q V A T A L P L E K P L N L V I M A V V I F S V L F T P Y H V M R N V R I A S R L G S W K Q Y Q C T Q V V I N S F Y I V T R P L A F L N S V I N P V F Y F L L G D H F R D M L M N Q L R H N F K S L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6IBB	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	-	-	-	2.12	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	6RNK	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	NF-56-EJ40	-	-	1.94	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	6Z10	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	PubChem 154585554	-	-	2.27	2020-09-16	doi.org/10.1021/acs.jmedchem.0c01020
	8JPN	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ1	2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPN (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	chim(Gs-CtGq)/β1/γ1	3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8YKW	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ1	2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKW (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-	Gi1/β1/γ1	2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-		2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8WOG	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ2	2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WOG (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ2	3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1 (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8YKV	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-	Gi1/β1/γ2	2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKV (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-		2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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