psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C11	R:R:C268	7.28	No	No	0	7	1
2	R:R:V272	R:R:W14	18.39	No	Yes	0	3	5
3	R:R:E18	R:R:V271	5.7	No	No	0	5	2
4	R:R:E18	R:R:N274	13.15	No	No	0	5	3
5	R:R:L21	R:R:Y25	7.03	No	Yes	0	4	4
6	R:R:E22	R:R:Y83	8.98	No	Yes	0	5	5
7	R:R:K23	R:R:Y24	10.75	No	No	0	4	3
8	R:R:F29	R:R:Y25	13.41	No	Yes	1	5	4
9	R:R:V279	R:R:Y25	5.05	No	Yes	0	5	4
10	R:R:P282	R:R:Y25	9.74	Yes	Yes	1	5	4
11	R:R:L26	R:R:Y30	8.21	Yes	Yes	1	6	8
12	R:R:L26	R:R:Y83	8.21	Yes	Yes	1	6	5
13	R:R:L26	R:R:P282	4.93	Yes	Yes	1	6	5
14	R:R:E33	R:R:F29	13.99	No	No	0	7	5
15	R:R:F29	R:R:P282	13	No	Yes	1	5	5
16	R:R:I80	R:R:Y30	4.84	No	Yes	0	6	8
17	R:R:P282	R:R:Y30	11.13	Yes	Yes	1	5	8
18	L:L:?1	R:R:Y30	10.45	Yes	Yes	1	0	8
19	R:R:E33	R:R:L286	11.93	No	No	0	7	5
20	R:R:E33	R:R:V289	5.7	No	No	0	7	8
21	R:R:F34	R:R:L73	4.87	Yes	No	0	7	6
22	R:R:F34	R:R:L76	8.53	Yes	No	0	7	8
23	R:R:F34	R:R:P77	13	Yes	No	0	7	8
24	R:R:V289	R:R:V36	4.81	No	No	0	8	6
25	R:R:G37	R:R:L73	5.13	No	No	0	8	6
26	R:R:D69	R:R:N41	6.73	Yes	No	0	9	9
27	R:R:L70	R:R:N41	5.49	No	No	0	8	9
28	R:R:N41	R:R:P292	8.15	No	No	0	9	9
29	R:R:S66	R:R:V44	4.85	No	No	0	9	9
30	R:R:F296	R:R:V44	17.04	Yes	No	0	6	9
31	R:R:F50	R:R:Y46	9.28	No	No	0	4	4
32	R:R:Q309	R:R:Y46	13.53	No	No	0	5	4
33	R:R:G47	R:R:L306	5.13	No	Yes	0	7	7
34	R:R:W55	R:R:Y48	5.79	No	Yes	2	6	7
35	R:R:N59	R:R:Y48	11.63	No	Yes	0	7	7
36	R:R:L62	R:R:Y48	5.86	No	Yes	2	8	7
37	R:R:F63	R:R:Y48	6.19	Yes	Yes	2	6	7
38	R:R:F296	R:R:Y48	9.28	Yes	Yes	2	6	7
39	R:R:F302	R:R:Y48	5.16	Yes	Yes	2	8	7
40	R:R:F50	R:R:I49	5.02	No	No	0	4	4
41	R:R:F63	R:R:I49	5.02	Yes	No	0	6	4
42	R:R:Q309	R:R:S51	10.11	No	No	0	5	5
43	R:R:L52	R:R:N59	5.49	No	No	0	5	7
44	R:R:F63	R:R:W55	13.03	Yes	No	2	6	6
45	R:R:N56	R:R:S58	5.96	Yes	No	0	7	8
46	R:R:N56	R:R:N59	10.9	Yes	No	0	7	7
47	R:R:N56	R:R:R129	12.05	Yes	No	0	7	5
48	R:R:S57	R:R:Y61	5.09	No	Yes	3	6	7
49	R:R:D119	R:R:S57	8.83	No	No	3	8	6
50	R:R:A139	R:R:I60	4.87	No	No	0	7	7
51	R:R:F115	R:R:Y61	10.32	No	Yes	3	6	7
52	R:R:D119	R:R:Y61	6.9	No	Yes	3	8	7
53	R:R:I142	R:R:Y61	9.67	No	Yes	3	5	7
54	R:R:F296	R:R:L62	6.09	Yes	No	2	6	8
55	R:R:F63	R:R:V67	6.55	Yes	No	0	6	7
56	R:R:F112	R:R:N64	13.29	No	No	6	8	9
57	R:R:N64	R:R:S143	7.45	No	No	0	9	7
58	R:R:N64	R:R:W147	5.65	No	No	6	9	9
59	R:R:L113	R:R:L65	6.92	No	No	0	8	9
60	R:R:S109	R:R:S68	4.89	No	No	0	9	8
61	R:R:D69	R:R:S109	5.89	Yes	No	0	9	9
62	R:R:D69	R:R:S288	5.89	Yes	No	0	9	9
63	R:R:D69	R:R:N291	6.73	Yes	No	0	9	9
64	R:R:A71	R:R:N105	4.69	No	No	0	6	8
65	R:R:F72	R:R:L102	7.31	Yes	No	1	7	7
66	R:R:F72	R:R:L106	6.09	Yes	No	0	7	8
67	R:R:F285	R:R:F72	12.86	No	Yes	1	7	7
68	R:R:F72	R:R:S288	6.61	Yes	No	0	7	9
69	R:R:L73	R:R:S288	6.01	No	No	0	6	9
70	R:R:N98	R:R:T75	7.31	No	No	0	4	6
71	R:R:L102	R:R:T75	5.9	No	No	0	7	6
72	R:R:M78	R:R:W88	6.98	No	Yes	8	7	8
73	R:R:M78	R:R:Y90	4.79	No	No	8	7	7
74	R:R:L79	R:R:Y83	4.69	No	Yes	1	6	5
75	L:L:?1	R:R:L79	6.86	Yes	No	1	0	6
76	R:R:S82	R:R:W88	7.41	No	Yes	0	5	8
77	R:R:R281	R:R:Y83	5.14	Yes	Yes	1	6	5
78	L:L:?1	R:R:Y83	10.45	Yes	Yes	1	0	5
79	R:R:I89	R:R:N87	5.66	No	No	0	3	4
80	R:R:W88	R:R:Y90	23.15	Yes	No	8	8	7
81	R:R:C95	R:R:W88	10.45	No	Yes	0	9	8
82	R:R:T170	R:R:W88	7.28	No	Yes	0	5	8
83	R:R:D92	R:R:P163	6.44	No	Yes	0	2	5
84	R:R:D92	R:R:T170	5.78	No	No	0	2	5
85	R:R:C95	R:R:R99	5.57	No	No	0	9	6
86	R:R:C172	R:R:C95	7.28	No	No	0	9	9
87	R:R:I96	R:R:N162	5.66	No	No	0	7	4
88	R:R:I161	R:R:R99	5.01	No	No	0	4	6
89	L:L:?1	R:R:R99	10.83	Yes	No	0	0	6
90	R:R:T151	R:R:Y100	4.99	No	Yes	0	4	6
91	R:R:L154	R:R:Y100	4.69	No	Yes	0	7	6
92	R:R:I157	R:R:Y100	4.84	No	Yes	0	4	6
93	R:R:L158	R:R:Y100	5.86	No	Yes	0	4	6
94	R:R:F285	R:R:L102	6.09	No	No	1	7	7
95	R:R:H103	R:R:I157	5.3	No	No	1	5	4
96	R:R:F175	R:R:H103	7.92	Yes	No	1	4	5
97	L:L:?1	R:R:H103	8.92	Yes	No	1	0	5
98	R:R:F245	R:R:L106	6.09	Yes	No	0	8	8
99	R:R:L191	R:R:Y107	17.58	No	Yes	0	5	7
100	R:R:H249	R:R:Y107	10.89	Yes	Yes	1	8	7
101	R:R:R252	R:R:Y107	6.17	Yes	Yes	1	6	7
102	R:R:T108	R:R:W147	8.49	Yes	No	0	7	9
103	R:R:T108	R:R:V150	6.35	Yes	No	0	7	8
104	R:R:F241	R:R:I110	7.54	Yes	No	1	9	8
105	R:R:F245	R:R:I110	11.3	Yes	No	1	8	8
106	R:R:F112	R:R:I146	11.3	No	No	0	8	7
107	R:R:F112	R:R:W147	8.02	No	No	6	8	9
108	R:R:L113	R:R:N291	6.87	No	No	7	8	9
109	R:R:L113	R:R:Y295	5.86	No	Yes	7	8	9
110	R:R:P199	R:R:T114	5.25	Yes	No	0	8	7
111	R:R:T114	R:R:V202	4.76	No	No	0	7	7
112	R:R:F115	R:R:I142	8.79	No	No	3	6	5
113	R:R:F115	R:R:I146	7.54	No	No	0	6	7
114	R:R:I116	R:R:R120	6.26	No	No	0	9	9
115	R:R:S117	R:R:Y207	10.17	No	Yes	0	9	9
116	R:R:F206	R:R:I118	13.82	No	No	0	8	6
117	R:R:R120	R:R:Y207	8.23	No	Yes	0	9	9
118	R:R:R120	R:R:Y295	9.26	No	Yes	0	9	9
119	R:R:K125	R:R:Y121	10.75	No	Yes	0	7	8
120	R:R:F206	R:R:Y121	9.28	No	Yes	0	8	8
121	R:R:K209	R:R:Y121	9.55	No	Yes	0	4	8
122	R:R:I210	R:R:Y121	4.84	Yes	Yes	0	8	8
123	R:R:H131	R:R:L122	6.43	No	No	0	4	5
124	R:R:L122	R:R:Q134	5.32	No	No	0	5	7
125	R:R:I123	R:R:R129	7.52	No	No	5	8	5
126	R:R:I123	R:R:Q134	5.49	No	No	5	8	7
127	R:R:F213	R:R:I124	7.54	No	No	0	5	8
128	R:R:K125	R:R:Y126	19.11	No	No	0	7	6
129	R:R:H131	R:R:Y126	13.07	No	No	0	4	6
130	R:R:E130	R:R:F128	8.16	No	No	0	5	5
131	R:R:Q134	R:R:R129	7.01	No	No	5	7	5
132	R:R:H131	R:R:L133	9	No	No	0	4	3
133	R:R:E137	R:R:K135	6.75	No	No	0	3	6
134	R:R:F138	R:R:K135	6.2	No	No	0	4	6
135	R:R:E153	R:R:L149	7.95	No	No	0	5	4
136	R:R:P156	R:R:Y187	6.95	No	No	0	8	5
137	R:R:F175	R:R:I157	10.05	Yes	No	1	4	4
138	R:R:P159	R:R:Y183	6.95	No	No	0	4	2
139	R:R:L160	R:R:Y183	10.55	No	No	0	5	2
140	R:R:L160	R:R:N184	9.61	No	Yes	0	5	3
141	R:R:C172	R:R:P163	9.41	No	Yes	0	9	5
142	R:R:D174	R:R:S177	5.89	Yes	No	0	5	4
143	R:R:D174	R:R:R281	10.72	Yes	Yes	1	5	6
144	L:L:?1	R:R:D174	5.38	Yes	Yes	1	0	5
145	R:R:F175	R:R:N184	8.46	Yes	Yes	0	4	3
146	R:R:F175	R:R:R252	9.62	Yes	Yes	1	4	6
147	R:R:A176	R:R:Y277	5.34	No	Yes	0	6	5
148	R:R:R255	R:R:S177	6.59	Yes	No	0	5	4
149	R:R:D180	R:R:P181	6.44	No	No	0	3	1
150	R:R:D180	R:R:N182	6.73	No	No	0	3	1
151	R:R:P181	R:R:R259	14.41	No	No	0	1	3
152	R:R:L260	R:R:N182	9.61	No	No	0	1	1
153	R:R:I186	R:R:Y183	4.84	No	No	0	4	2
154	R:R:I256	R:R:N184	12.74	No	Yes	0	5	3
155	R:R:N184	R:R:R259	4.82	Yes	No	0	3	3
156	R:R:L191	R:R:Y187	14.07	No	No	0	5	5
157	R:R:R252	R:R:S188	9.22	Yes	No	0	6	5
158	R:R:I256	R:R:S188	4.64	No	No	0	5	5
159	R:R:M189	R:R:N253	7.01	No	No	0	5	6
160	R:R:H249	R:R:T192	9.58	Yes	No	0	8	6
161	R:R:N253	R:R:T192	5.85	No	No	0	6	6
162	R:R:F196	R:R:L200	7.31	Yes	No	0	8	6
163	R:R:F196	R:R:F245	6.43	Yes	Yes	1	8	8
164	R:R:F196	R:R:T246	6.49	Yes	Yes	0	8	5
165	R:R:F196	R:R:H249	23.76	Yes	Yes	1	8	8
166	R:R:F241	R:R:L200	4.87	Yes	No	0	9	6
167	R:R:M203	R:R:Y207	4.79	No	Yes	0	8	9
168	R:R:F241	R:R:M203	12.44	Yes	No	0	9	8
169	R:R:F205	R:R:F206	11.79	No	No	0	4	8
170	R:R:F205	R:R:K209	8.69	No	No	0	4	4
171	R:R:V234	R:R:Y207	6.31	Yes	Yes	0	8	9
172	R:R:L212	R:R:Y208	14.07	No	No	0	3	3
173	R:R:I210	R:R:V234	4.61	Yes	Yes	0	8	8
174	R:R:K215	R:R:R219	11.14	No	No	0	4	4
175	R:R:Q216	R:R:R219	4.67	No	No	0	5	4
176	R:R:N218	R:R:R217	7.23	No	Yes	4	4	5
177	R:R:R217	R:R:V221	6.54	Yes	No	0	5	3
178	R:R:L225	R:R:R217	12.15	No	Yes	4	3	5
179	R:R:L227	R:R:R217	9.72	Yes	Yes	4	6	5
180	R:R:L227	R:R:N218	6.87	Yes	No	4	6	4
181	R:R:T223	R:R:V221	4.76	No	No	0	4	3
182	R:R:L225	R:R:L227	11.07	No	Yes	4	3	6
183	R:R:E228	R:R:P226	6.29	No	No	0	5	5
184	R:R:K229	R:R:L233	8.46	No	No	0	7	8
185	R:R:F241	R:R:F245	7.5	Yes	Yes	1	9	8
186	R:R:S242	R:R:T246	4.8	No	Yes	0	6	5
187	R:R:L244	R:R:L286	6.92	Yes	No	0	9	5
188	R:R:L244	R:R:N287	6.87	Yes	No	0	9	9
189	R:R:F245	R:R:H249	6.79	Yes	Yes	1	8	8
190	R:R:F245	R:R:N287	10.87	Yes	No	0	8	9
191	R:R:H249	R:R:Y248	6.53	Yes	Yes	1	8	7
192	R:R:R252	R:R:Y248	14.4	Yes	Yes	1	6	7
193	R:R:Y248	R:R:Y277	5.96	Yes	Yes	1	7	5
194	R:R:A284	R:R:Y248	5.34	No	Yes	0	8	7
195	R:R:H249	R:R:R252	5.64	Yes	Yes	1	8	6
196	R:R:M251	R:R:T280	6.02	No	No	0	4	7
197	R:R:R252	R:R:Y277	10.29	Yes	Yes	1	6	5
198	R:R:R255	R:R:R259	5.33	Yes	No	0	5	3
199	R:R:N274	R:R:R255	21.69	No	Yes	0	3	5
200	R:R:R255	R:R:Y277	9.26	Yes	Yes	0	5	5
201	R:R:I273	R:R:S258	9.29	No	No	0	5	2
202	R:R:L260	R:R:S262	6.01	No	No	0	1	1
203	R:R:G261	R:R:K264	6.97	No	No	0	2	3
204	R:R:T269	R:R:Y266	7.49	No	No	0	1	5
205	R:R:Q267	R:R:V271	7.16	No	No	0	7	2
206	R:R:N274	R:R:Q270	5.28	No	No	0	3	3
207	R:R:T280	R:R:Y277	4.99	No	Yes	0	7	5
208	R:R:R281	R:R:Y277	16.46	Yes	Yes	1	6	5
209	L:L:?1	R:R:R281	19.26	Yes	Yes	1	0	6
210	L:L:?1	R:R:F285	4.83	Yes	No	1	0	7
211	R:R:I290	R:R:L286	8.56	No	No	0	6	5
212	R:R:N291	R:R:Y295	5.81	No	Yes	7	9	9
213	R:R:F294	R:R:Y295	6.19	No	Yes	0	7	9
214	R:R:F296	R:R:F302	7.5	Yes	Yes	2	6	8
215	R:R:F302	R:R:L306	12.18	Yes	Yes	0	8	7
216	R:R:F314	R:R:R311	6.41	No	No	0	2	5
217	R:R:K315	R:R:R311	6.19	No	No	0	4	5
218	R:R:L317	R:R:S316	6.01	No	No	0	3	7
219	R:R:C11	R:R:Q267	4.58	No	No	0	7	7
220	R:R:M251	R:R:V254	4.56	No	No	0	4	5
221	R:R:I124	R:R:I210	4.42	No	Yes	9	8	8
222	R:R:N105	R:R:T108	4.39	No	Yes	0	8	7
223	R:R:I240	R:R:M236	4.37	No	No	0	7	5
224	R:R:I273	R:R:M251	4.37	No	No	0	5	4
225	R:R:I60	R:R:K136	4.36	No	No	0	7	1
226	R:R:P77	R:R:R81	4.32	No	No	0	8	5
227	R:R:I278	R:R:L21	4.28	No	No	0	4	4
228	R:R:I278	R:R:L26	4.28	No	Yes	0	4	6
229	R:R:I256	R:R:L185	4.28	No	No	0	5	4
230	R:R:L94	R:R:M78	4.24	No	No	0	6	7
231	R:R:K215	R:R:N218	4.2	No	No	0	4	4
232	R:R:L244	R:R:L283	4.15	Yes	No	0	9	7
233	R:R:L317	R:R:N313	4.12	No	No	0	3	2
234	R:R:K264	R:R:Q265	4.07	No	No	0	3	1
235	R:R:A139	R:R:Y61	4	No	Yes	0	7	7
236	R:R:A237	R:R:Y207	4	No	Yes	0	8	9
237	R:R:F34	R:R:V38	3.93	Yes	No	0	7	6
238	R:R:F63	R:R:V45	3.93	Yes	No	0	6	8
239	R:R:F294	R:R:I240	3.77	No	No	0	7	7
240	R:R:M307	R:R:R303	3.72	No	No	0	4	8
241	R:R:S275	R:R:W14	3.71	No	Yes	0	1	5
242	R:R:H312	R:R:Q309	3.71	No	No	0	3	5
243	R:R:I89	R:R:Y90	3.63	No	No	0	3	7
244	R:R:G40	R:R:I43	3.53	No	No	0	8	6
245	R:R:P163	R:R:T171	3.5	Yes	No	0	5	3
246	R:R:P247	R:R:T246	3.5	No	Yes	0	9	5
247	R:R:N313	R:R:Y46	3.49	No	No	0	2	4
248	R:R:C204	R:R:V238	3.42	No	No	0	5	8
249	R:R:G86	R:R:N85	3.39	No	No	0	4	3
250	R:R:I96	R:R:P163	3.39	No	Yes	0	7	5
251	R:R:I110	R:R:P199	3.39	No	Yes	0	8	8
252	R:R:I198	R:R:P199	3.39	No	Yes	0	6	8
253	R:R:Q265	R:R:Y266	3.38	No	No	0	1	5
254	R:R:K229	R:R:P230	3.35	No	No	0	7	7
255	R:R:L111	R:R:P199	3.28	No	Yes	0	6	8
256	R:R:L227	R:R:P230	3.28	Yes	No	0	6	7
257	R:R:S68	R:R:T108	3.2	No	Yes	0	8	7
258	R:R:C74	R:R:L70	3.17	No	No	0	5	8
259	R:R:T75	R:R:V101	3.17	No	No	0	6	5
260	R:R:C204	R:R:L200	3.17	No	No	0	5	6
261	R:R:A104	R:R:L154	3.15	No	No	0	5	7
262	R:R:M236	R:R:V239	3.04	No	No	0	5	5
263	R:R:F276	R:R:W14	3.01	No	Yes	0	5	5
264	R:R:L21	R:R:S275	3	No	No	0	4	1
265	R:R:L15	R:R:V271	2.98	No	No	0	7	2
266	R:R:L39	R:R:T42	2.95	No	No	0	4	4
267	R:R:I140	R:R:I60	2.94	No	No	0	4	7
268	R:R:G195	R:R:Y107	2.9	No	Yes	0	6	7
269	R:R:I43	R:R:L306	2.85	No	Yes	0	6	7
270	R:R:I124	R:R:L214	2.85	No	No	9	8	7
271	R:R:I210	R:R:L214	2.85	Yes	No	9	8	7
272	R:R:I89	R:R:N85	2.83	No	No	0	3	3
273	R:R:L193	R:R:M189	2.83	No	No	0	5	5
274	R:R:D92	R:R:I165	2.8	No	No	0	2	1
275	R:R:L193	R:R:L197	2.77	No	No	0	5	4
276	R:R:E137	R:R:K136	2.7	No	No	0	3	1
277	R:R:E153	R:R:L194	2.65	No	No	0	5	5
278	R:R:Q216	R:R:Q220	2.56	No	No	0	5	2
279	R:R:D300	R:R:H301	2.52	No	No	0	5	6
280	R:R:F201	R:R:L197	2.44	No	No	0	3	4
281	R:R:F302	R:R:L297	2.44	Yes	No	0	8	7
282	R:R:T10	R:R:W14	2.43	No	Yes	0	9	5
283	R:R:L155	R:R:Y100	2.34	No	Yes	0	4	6
284	R:R:L260	R:R:W263	2.28	No	No	0	1	1
285	R:R:G179	R:R:S178	1.86	No	No	0	1	3
286	R:R:G31	R:R:I80	1.76	No	No	0	5	6
287	R:R:A84	R:R:S27	1.71	No	No	0	5	5
288	R:R:G40	R:R:L39	1.71	No	No	0	8	4
289	R:R:G179	R:R:L160	1.71	No	No	0	1	5
290	R:R:E153	R:R:G195	1.64	No	No	0	5	6
291	R:R:L214	R:R:P230	1.64	No	No	0	7	7
292	R:R:L225	R:R:P226	1.64	No	No	0	3	5
293	R:R:T171	R:R:V164	1.59	No	No	0	3	1
294	R:R:T246	R:R:V250	1.59	Yes	No	0	5	7
295	R:R:A257	R:R:L185	1.58	No	No	0	4	4
296	R:R:A211	R:R:L231	1.58	No	No	0	5	6
297	R:R:I28	R:R:S27	1.55	No	No	0	6	5
298	R:R:I80	R:R:S27	1.55	No	No	0	6	5
299	R:R:I32	R:R:V36	1.54	No	No	0	6	6
300	R:R:I235	R:R:V234	1.54	No	Yes	0	4	8
301	R:R:I235	R:R:V239	1.54	No	No	0	4	5
302	R:R:G299	R:R:R303	1.5	No	No	0	8	8
303	R:R:L231	R:R:V234	1.49	No	Yes	0	6	8
304	R:R:L244	R:R:V243	1.49	Yes	No	0	9	6
305	R:R:L298	R:R:V293	1.49	No	No	0	6	6
306	R:R:N13	R:R:T10	1.46	No	No	0	6	9
307	R:R:I142	R:R:L141	1.43	No	No	0	5	2
308	R:R:L306	R:R:M305	1.41	Yes	No	0	7	4
309	R:R:M236	R:R:N232	1.4	No	No	0	5	5
310	R:R:P127	R:R:Y126	1.39	No	No	0	8	6
311	R:R:L152	R:R:L155	1.38	No	No	0	4	4
312	R:R:L233	R:R:L298	1.38	No	No	0	8	6
313	R:R:N54	R:R:N56	1.36	No	Yes	0	6	7
314	R:R:D174	R:R:N173	1.35	Yes	No	0	5	4
315	R:R:L212	R:R:Q216	1.33	No	No	0	3	5
316	R:R:D300	R:R:D304	1.33	No	No	0	5	4
317	R:R:A17	R:R:W14	1.3	No	Yes	0	2	5
318	R:R:H301	R:R:L52	1.29	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W14	5.768	5	0	5
2	R:R:Y25	8.8075	4	1	4
3	R:R:L26	6.4075	4	1	6
4	R:R:Y30	8.6575	4	1	8
5	R:R:F34	7.5825	4	0	7
6	R:R:Y48	7.31833	6	2	7
7	R:R:N56	7.5675	4	0	7
8	R:R:Y61	7.196	5	3	7
9	R:R:F63	6.944	5	2	6
10	R:R:D69	6.31	4	0	9
11	R:R:F72	8.2175	4	1	7
12	R:R:Y83	7.494	5	1	5
13	R:R:W88	11.054	5	8	8
14	R:R:Y100	4.544	5	0	6
15	R:R:Y107	9.385	4	1	7
16	R:R:T108	5.6075	4	0	7
17	R:R:Y121	8.605	4	0	8
18	R:R:P163	5.685	4	0	5
19	R:R:D174	5.835	4	1	5
20	R:R:F175	9.0125	4	1	4
21	R:R:N184	8.9075	4	0	3
22	R:R:F196	10.9975	4	1	8
23	R:R:P199	3.8275	4	0	8
24	R:R:Y207	6.7	5	0	9
25	R:R:I210	4.18	4	9	8
26	R:R:R217	8.91	4	4	5
27	R:R:L227	7.735	4	4	6
28	R:R:V234	3.4875	4	0	8
29	R:R:F241	8.0875	4	1	9
30	R:R:L244	4.8575	4	0	9
31	R:R:F245	8.16333	6	1	8
32	R:R:T246	4.095	4	0	5
33	R:R:Y248	8.0575	4	1	7
34	R:R:H249	10.5317	6	1	8
35	R:R:R252	9.22333	6	1	6
36	R:R:R255	10.7175	4	0	5
37	R:R:Y277	8.71667	6	1	5
38	R:R:R281	12.895	4	1	6
39	R:R:P282	9.7	4	1	5
40	R:R:Y295	6.78	4	7	9
41	R:R:F296	9.9775	4	2	6
42	R:R:F302	6.82	4	2	8
43	R:R:L306	5.3925	4	0	7
44	L:L:?1	9.6225	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E18	R:R:V271	13.0637	5.7	No	No	0	5	2
2	R:R:E18	R:R:N274	15.428	13.15	No	No	0	5	3
3	R:R:N274	R:R:R255	20.3549	21.69	No	Yes	0	3	5
4	R:R:R255	R:R:Y277	32.1451	9.26	Yes	Yes	0	5	5
5	R:R:R281	R:R:Y277	31.6284	16.46	Yes	Yes	1	6	5
6	R:R:R281	R:R:Y83	10.0261	5.14	Yes	Yes	1	6	5
7	R:R:L26	R:R:Y83	13.8361	8.21	Yes	Yes	1	6	5
8	R:R:I278	R:R:L26	15.2871	4.28	No	Yes	0	4	6
9	R:R:I278	R:R:L21	11.9624	4.28	No	No	0	4	4
10	R:R:L21	R:R:S275	18.5282	3	No	No	0	4	1
11	R:R:S275	R:R:W14	15.9969	3.71	No	Yes	0	1	5
12	L:L:?1	R:R:D174	10.6002	5.38	Yes	Yes	1	0	5
13	L:L:?1	R:R:Y30	28.7839	10.45	Yes	Yes	1	0	8
14	R:R:P282	R:R:Y30	13.1994	11.13	Yes	Yes	1	5	8
15	L:L:?1	R:R:R281	18.6691	19.26	Yes	Yes	1	0	6
16	R:R:E33	R:R:F29	12.0511	13.99	No	No	0	7	5
17	R:R:Y248	R:R:Y277	22.6461	5.96	Yes	Yes	1	7	5
18	R:R:H249	R:R:Y248	23.6273	6.53	Yes	Yes	1	8	7
19	R:R:F245	R:R:H249	62.5678	6.79	Yes	Yes	1	8	8
20	R:R:F245	R:R:N287	18.7422	10.87	Yes	No	0	8	9
21	R:R:L244	R:R:N287	17.3539	6.87	Yes	No	0	9	9
22	R:R:L244	R:R:L286	13.7839	6.92	Yes	No	0	9	5
23	R:R:R252	R:R:Y277	27.453	10.29	Yes	Yes	1	6	5
24	R:R:H249	R:R:R252	43.382	5.64	Yes	Yes	1	8	6
25	L:L:?1	R:R:F285	58.8257	4.83	Yes	No	1	0	7
26	R:R:F285	R:R:F72	55.8716	12.86	No	Yes	1	7	7
27	R:R:F72	R:R:S288	45	6.61	Yes	No	0	7	9
28	R:R:L73	R:R:S288	11.6493	6.01	No	No	0	6	9
29	R:R:D69	R:R:S288	41.7432	5.89	Yes	No	0	9	9
30	R:R:F241	R:R:F245	84.2589	7.5	Yes	Yes	1	9	8
31	R:R:F241	R:R:M203	88.737	12.44	Yes	No	0	9	8
32	R:R:M203	R:R:Y207	88.2881	4.79	No	Yes	0	8	9
33	R:R:V234	R:R:Y207	100	6.31	Yes	Yes	0	8	9
34	R:R:I210	R:R:V234	95.4541	4.61	Yes	Yes	0	8	8
35	R:R:I210	R:R:Y121	71.1587	4.84	Yes	Yes	0	8	8
36	R:R:K125	R:R:Y121	63.8622	10.75	No	Yes	0	7	8
37	R:R:K125	R:R:Y126	62.6096	19.11	No	No	0	7	6
38	R:R:H131	R:R:Y126	60.0731	13.07	No	No	0	4	6
39	R:R:H131	R:R:L122	57.4948	6.43	No	No	0	4	5
40	R:R:L122	R:R:Q134	56.19	5.32	No	No	0	5	7
41	R:R:Q134	R:R:R129	53.3612	7.01	No	No	5	7	5
42	R:R:N56	R:R:R129	52.166	12.05	Yes	No	0	7	5
43	R:R:N56	R:R:N59	48.3142	10.9	Yes	No	0	7	7
44	R:R:N59	R:R:Y48	41.5188	11.63	No	Yes	0	7	7
45	R:R:F63	R:R:Y48	19.3789	6.19	Yes	Yes	2	6	7
46	R:R:F63	R:R:I49	14.6608	5.02	Yes	No	0	6	4
47	R:R:F50	R:R:I49	13.0532	5.02	No	No	0	4	4
48	R:R:F50	R:R:Y46	11.4248	9.28	No	No	0	4	4
49	R:R:F302	R:R:Y48	14.5042	5.16	Yes	Yes	2	8	7
50	R:R:F302	R:R:L306	11.5814	12.18	Yes	Yes	0	8	7
51	R:R:D69	R:R:S109	37.7088	5.89	Yes	No	0	9	9
52	R:R:S109	R:R:S68	36.2526	4.89	No	No	0	9	8
53	R:R:S68	R:R:T108	34.786	3.2	No	Yes	0	8	7
54	R:R:T108	R:R:W147	28.8152	8.49	Yes	No	0	7	9
55	R:R:F112	R:R:W147	24.071	8.02	No	No	6	8	9
56	R:R:F112	R:R:I146	22.6775	11.3	No	No	0	8	7
57	R:R:F115	R:R:I146	21.1117	7.54	No	No	0	6	7
58	R:R:F115	R:R:Y61	16.2683	10.32	No	Yes	3	6	7
59	R:R:A139	R:R:Y61	11.5188	4	No	Yes	0	7	7
60	R:R:A139	R:R:I60	10.0104	4.87	No	No	0	7	7
61	R:R:D69	R:R:N291	24.6503	6.73	Yes	No	0	9	9
62	R:R:F245	R:R:L106	36.6493	6.09	Yes	No	0	8	8
63	L:L:?1	R:R:R99	41.7693	10.83	Yes	No	0	0	6
64	R:R:C95	R:R:R99	38.3559	5.57	No	No	0	9	6
65	R:R:C95	R:R:W88	22.2651	10.45	No	Yes	0	9	8
66	R:R:C172	R:R:C95	14.9374	7.28	No	No	0	9	9
67	R:R:C172	R:R:P163	13.095	9.41	No	Yes	0	9	5
68	R:R:R255	R:R:R259	18.3873	5.33	Yes	No	0	5	3
69	R:R:F175	R:R:N184	20.4332	8.46	Yes	Yes	0	4	3
70	R:R:I157	R:R:Y100	10.9551	4.84	No	Yes	0	4	6
71	R:R:F175	R:R:R252	21.5188	9.62	Yes	Yes	1	4	6
72	L:L:?1	R:R:H103	20.6576	8.92	Yes	No	1	0	5
73	R:R:F175	R:R:H103	15.4019	7.92	Yes	No	1	4	5
74	R:R:N291	R:R:Y295	21.6754	5.81	No	Yes	7	9	9
75	R:R:R120	R:R:Y207	22.1294	8.23	No	Yes	0	9	9
76	R:R:R120	R:R:Y295	21.1169	9.26	No	Yes	0	9	9
77	R:R:P181	R:R:R259	22.0407	14.41	No	No	0	1	3
78	R:R:D180	R:R:P181	18.3925	6.44	No	No	0	3	1
79	R:R:D180	R:R:N182	14.7338	6.73	No	No	0	3	1
80	R:R:L260	R:R:N182	11.0647	9.61	No	No	0	1	1
81	R:R:H249	R:R:T192	12.3643	9.58	Yes	No	0	8	6
82	R:R:N253	R:R:T192	10.3288	5.85	No	No	0	6	6
83	R:R:F196	R:R:T246	10.8507	6.49	Yes	Yes	0	8	5
84	R:R:I210	R:R:L214	31.524	2.85	Yes	No	9	8	7
85	R:R:L214	R:R:P230	30.2035	1.64	No	No	0	7	7
86	R:R:L227	R:R:P230	22.8445	3.28	Yes	No	0	6	7
87	R:R:L227	R:R:N218	11.5658	6.87	Yes	No	4	6	4
88	R:R:K215	R:R:N218	10.1409	4.2	No	No	0	4	4
89	R:R:T280	R:R:Y277	10.6681	4.99	No	Yes	0	7	5
90	R:R:E33	R:R:L286	11.8633	11.93	No	No	0	7	5
91	R:R:F72	R:R:L106	36.2422	6.09	Yes	No	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E22	R:R:Y83	8.98	0	No	Yes	5	5	2	1
R:R:L26	R:R:Y30	8.21	1	Yes	Yes	6	8	2	1
R:R:L26	R:R:Y83	8.21	1	Yes	Yes	6	5	2	1
R:R:L26	R:R:P282	4.93	1	Yes	Yes	6	5	2	2
R:R:I80	R:R:Y30	4.84	0	No	Yes	6	8	2	1
R:R:P282	R:R:Y30	11.13	1	Yes	Yes	5	8	2	1
L:L:?1	R:R:Y30	10.45	1	Yes	Yes	0	8	0	1
R:R:F72	R:R:L102	7.31	1	Yes	No	7	7	2	2
R:R:F285	R:R:F72	12.86	1	No	Yes	7	7	1	2
R:R:L79	R:R:Y83	4.69	1	No	Yes	6	5	1	1
L:L:?1	R:R:L79	6.86	1	Yes	No	0	6	0	1
R:R:R281	R:R:Y83	5.14	1	Yes	Yes	6	5	1	1
L:L:?1	R:R:Y83	10.45	1	Yes	Yes	0	5	0	1
R:R:C95	R:R:R99	5.57	0	No	No	9	6	2	1
R:R:I161	R:R:R99	5.01	0	No	No	4	6	2	1
L:L:?1	R:R:R99	10.83	1	Yes	No	0	6	0	1
R:R:F285	R:R:L102	6.09	1	No	No	7	7	1	2
R:R:H103	R:R:I157	5.3	1	No	No	5	4	1	2
R:R:F175	R:R:H103	7.92	1	Yes	No	4	5	2	1
L:L:?1	R:R:H103	8.92	1	Yes	No	0	5	0	1
R:R:F175	R:R:I157	10.05	1	Yes	No	4	4	2	2
R:R:D174	R:R:S177	5.89	1	Yes	No	5	4	1	2
R:R:D174	R:R:R281	10.72	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:D174	5.38	1	Yes	Yes	0	5	0	1
R:R:R281	R:R:Y277	16.46	1	Yes	Yes	6	5	1	2
L:L:?1	R:R:R281	19.26	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F285	4.83	1	Yes	No	0	7	0	1
R:R:D174	R:R:N173	1.35	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JPP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.6
Number of Linked Nodes	287
Number of Links	318
Number of Hubs	44
Number of Links mediated by Hubs	161
Number of Communities	9
Number of Nodes involved in Communities	55
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	92
Number Of Links MetaPath	91
Number of Shortest Paths	50187
Length Of Smallest Path	3
Average Path Length	14.1247
Length of Longest Path	38
Minimum Path Strength	1.435
Average Path Strength	7.69339
Maximum Path Strength	17.86
Minimum Path Correlation	0.7
Average Path Correlation	0.929014
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	49.5744
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.714
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • macrophage activation involved in immune response • immune response • cell activation • cell activation involved in immune response • myeloid cell activation involved in immune response • myeloid leukocyte activation • leukocyte activation • immune effector process • macrophage activation • immune system process • leukocyte activation involved in immune response • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • response to metal ion • response to calcium ion • chemotaxis • positive regulation of locomotion • regulation of chemotaxis • positive regulation of chemotaxis • taxis • regulation of locomotion • locomotion • regulation of systemic arterial blood pressure by renin-angiotensin • protein localization • renin secretion into blood stream • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • establishment of protein localization • cellular localization • nitrogen compound transport • transport • protein localization to extracellular region • localization • secretion by cell • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • signal release • cellular macromolecule localization • renal system process involved in regulation of systemic arterial blood pressure • regulation of biological quality • blood circulation • renal system process • secretion • regulation of blood pressure • establishment of protein localization to extracellular region • export from cell • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • regulation of systemic arterial blood pressure • endocrine process • protein transport • macromolecule localization • regulation of protein metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of primary metabolic process • regulation of angiotensin metabolic process • protein metabolic process • macromolecule metabolic process • regulation of metabolic process • multicellular organismal-level homeostasis • homeostatic process • energy homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • periplasmic space
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SIN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SIN
Name	Succinic acid
Synonyms	Acidum succinicum
Identifier
Formula	C4 H6 O4
Molecular Weight	118.088
SMILES
PubChem	21952380
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	13
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXA5
Sequence	>8JPP_nogp_Chain_R T C K N W L A A E A A L E K Y Y L S I F Y G I E F V V G V L G N T I V V Y G Y I F S L K N W N S S N I Y L F N L S V S D L A F L C T L P M L I R S Y A N G N W I Y G D V L C I S N R Y V L H A N L Y T S I L F L T F I S I D R Y L I I K Y P F R E H L L Q K K E F A I L I S L A I W V L V T L E L L P I L P L I N P V I G T T C N D F A S S G D P N Y N L I Y S M C L T L L G F L I P L F V M C F F Y Y K I A L F L K Q R N R Q V A T A L P L E K P L N L V I M A V V I F S V L F T P Y H V M R N V R I A S R L G S W K Q Y Q C T Q V V I N S F Y I V T R P L A F L N S V I N P V F Y F L L G D H F R D M L M N Q L R H N F K S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WP1	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ2	3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1 (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WOG	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ2	2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WOG (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8YKX	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-	Gi1/β1/γ1	2.69	2024-05-29	10.1038/s41422-024-00984-7
	8YKX (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-		2.69	2024-05-29	10.1038/s41422-024-00984-7
	8YKW	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ1	2.75	2024-05-29	10.1038/s41422-024-00984-7
	8YKW (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.75	2024-05-29	10.1038/s41422-024-00984-7
	8YKV	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-	Gi1/β1/γ2	2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKV (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-		2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8JPP	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	chim(Gs-CtGq)/β1/γ1	3.2	2024-05-22	10.1038/s41422-024-00968-7
	8JPP (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		3.2	2024-05-22	10.1038/s41422-024-00968-7
	8JPN	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ1	2.9	2024-05-22	10.1038/s41422-024-00968-7
	8JPN (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		2.9	2024-05-22	10.1038/s41422-024-00968-7
	6Z10	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	PubChem 154585554	-	-	2.27	2020-09-16	10.1021/acs.jmedchem.0c01020
	6RNK	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	NF-56-EJ40	-	-	1.94	2019-08-14	10.1038/s41586-019-1663-8
	6IBB	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	-	-	-	2.12	2019-08-14	10.1038/s41586-019-1663-8

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