psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y30	5.2	Yes	Yes	3	0	8
2	L:L:?1	R:R:L79	6.14	Yes	No	3	0	6
3	L:L:?1	R:R:Y83	6.24	Yes	No	3	0	5
4	L:L:?1	R:R:R99	14.02	Yes	No	0	0	6
5	L:L:?1	R:R:L102	3.69	Yes	No	0	0	7
6	L:L:?1	R:R:H103	5.71	Yes	No	0	0	5
7	L:L:?1	R:R:D174	7.23	Yes	No	0	0	5
8	L:L:?1	R:R:R281	22.65	Yes	No	0	0	6
9	R:R:C11	R:R:C268	7.28	No	No	0	7	1
10	R:R:N13	R:R:W14	7.91	No	No	0	6	5
11	R:R:V272	R:R:W14	18.39	No	No	0	3	5
12	R:R:S275	R:R:W14	4.94	No	No	0	1	5
13	R:R:E18	R:R:L15	3.98	No	No	0	5	7
14	R:R:E18	R:R:E22	6.34	No	No	0	5	5
15	R:R:E18	R:R:N274	5.26	No	No	0	5	3
16	R:R:F29	R:R:Y25	9.28	No	No	4	5	4
17	R:R:V279	R:R:Y25	6.31	No	No	0	5	4
18	R:R:P282	R:R:Y25	8.34	No	No	4	5	4
19	R:R:L26	R:R:Y30	5.86	No	Yes	0	6	8
20	R:R:I28	R:R:I32	5.89	No	No	0	6	6
21	R:R:E33	R:R:F29	10.49	Yes	No	0	7	5
22	R:R:F29	R:R:P282	10.11	No	No	4	5	5
23	R:R:L76	R:R:Y30	7.03	No	Yes	0	8	8
24	R:R:L79	R:R:Y30	7.03	No	Yes	3	6	8
25	R:R:I80	R:R:Y30	4.84	No	Yes	0	6	8
26	R:R:F285	R:R:Y30	7.22	No	Yes	0	7	8
27	R:R:E33	R:R:F285	5.83	Yes	No	0	7	7
28	R:R:E33	R:R:L286	3.98	Yes	No	0	7	5
29	R:R:F34	R:R:V38	7.87	No	No	0	7	6
30	R:R:F34	R:R:L76	3.65	No	No	0	7	8
31	R:R:F34	R:R:P77	7.22	No	No	0	7	8
32	R:R:V289	R:R:V36	4.81	No	No	0	8	6
33	R:R:G37	R:R:V289	5.52	No	No	0	8	8
34	R:R:G40	R:R:P292	4.06	No	No	0	8	9
35	R:R:D69	R:R:N41	14.81	No	No	0	9	9
36	R:R:N41	R:R:P292	4.89	No	No	0	9	9
37	R:R:F296	R:R:V44	11.8	No	No	0	6	9
38	R:R:F46	R:R:F50	7.5	No	No	0	4	4
39	R:R:W55	R:R:Y48	4.82	No	Yes	5	6	7
40	R:R:N59	R:R:Y48	10.47	No	Yes	0	7	7
41	R:R:F63	R:R:Y48	7.22	Yes	Yes	5	6	7
42	R:R:F296	R:R:Y48	5.16	No	Yes	0	6	7
43	R:R:F302	R:R:Y48	5.16	Yes	Yes	0	8	7
44	R:R:F63	R:R:L49	3.65	Yes	No	0	6	4
45	R:R:C51	R:R:K309	6.47	No	No	0	5	5
46	R:R:L52	R:R:W55	14.81	No	No	0	5	6
47	R:R:F63	R:R:W55	8.02	Yes	No	5	6	6
48	R:R:N56	R:R:S58	4.47	Yes	No	0	7	8
49	R:R:N56	R:R:N59	9.54	Yes	No	0	7	7
50	R:R:N56	R:R:R129	13.26	Yes	No	0	7	5
51	R:R:D119	R:R:S57	5.89	No	No	0	8	6
52	R:R:D119	R:R:S58	5.89	No	No	0	8	8
53	R:R:A139	R:R:I60	4.87	No	No	0	7	7
54	R:R:F115	R:R:Y61	6.19	No	Yes	6	6	7
55	R:R:D119	R:R:Y61	4.6	No	Yes	0	8	7
56	R:R:A139	R:R:Y61	4	No	Yes	0	7	7
57	R:R:I142	R:R:Y61	4.84	No	Yes	6	5	7
58	R:R:I116	R:R:L62	5.71	No	No	0	9	8
59	R:R:F296	R:R:L62	9.74	No	No	0	6	8
60	R:R:F63	R:R:S66	3.96	Yes	No	0	6	9
61	R:R:F63	R:R:I67	7.54	Yes	No	0	6	7
62	R:R:F112	R:R:N64	10.87	Yes	No	2	8	9
63	R:R:N64	R:R:S143	5.96	No	No	2	9	7
64	R:R:L113	R:R:L65	4.15	No	No	7	8	9
65	R:R:L65	R:R:N291	5.49	No	No	7	9	9
66	R:R:N105	R:R:S68	5.96	No	Yes	0	8	8
67	R:R:S68	R:R:T108	4.8	Yes	No	2	8	7
68	R:R:S68	R:R:W147	4.94	Yes	No	2	8	9
69	R:R:D69	R:R:L73	4.07	No	No	0	9	6
70	R:R:D69	R:R:S288	10.31	No	No	0	9	9
71	R:R:A71	R:R:N105	4.69	No	No	0	6	8
72	R:R:F72	R:R:L73	6.09	Yes	No	0	7	6
73	R:R:F72	R:R:L102	6.09	Yes	No	0	7	7
74	R:R:F285	R:R:F72	11.79	No	Yes	0	7	7
75	R:R:F72	R:R:S288	5.28	Yes	No	0	7	9
76	R:R:N98	R:R:T75	7.31	No	No	0	4	6
77	R:R:L102	R:R:T75	4.42	No	No	0	7	6
78	R:R:M78	R:R:N98	7.01	No	No	0	7	4
79	R:R:L79	R:R:Y83	5.86	No	No	3	6	5
80	R:R:N85	R:R:R81	13.26	No	No	0	3	5
81	R:R:S82	R:R:W88	7.41	No	Yes	0	5	8
82	R:R:W88	R:R:Y90	12.54	Yes	No	0	8	7
83	R:R:C95	R:R:W88	15.67	No	Yes	8	9	8
84	R:R:C172	R:R:W88	5.22	No	Yes	8	9	8
85	R:R:I89	R:R:Y90	9.67	No	No	0	3	7
86	R:R:D92	R:R:P163	6.44	No	No	0	2	5
87	R:R:C172	R:R:C95	7.28	No	No	8	9	9
88	R:R:I96	R:R:P163	6.77	No	No	0	7	5
89	R:R:I161	R:R:R99	3.76	No	No	0	4	6
90	R:R:L155	R:R:Y100	5.86	No	Yes	0	4	6
91	R:R:L158	R:R:Y100	4.69	No	Yes	0	4	6
92	R:R:N105	R:R:V101	4.43	No	No	0	8	5
93	R:R:F245	R:R:L106	3.65	Yes	No	0	8	8
94	R:R:L191	R:R:Y107	7.03	No	Yes	0	5	7
95	R:R:H249	R:R:Y107	4.36	Yes	Yes	1	8	7
96	R:R:R252	R:R:Y107	4.12	Yes	Yes	1	6	7
97	R:R:T108	R:R:W147	10.92	No	No	2	7	9
98	R:R:T108	R:R:V150	6.35	No	No	0	7	8
99	R:R:F241	R:R:I110	3.77	Yes	No	1	9	8
100	R:R:F245	R:R:I110	12.56	Yes	No	1	8	8
101	R:R:I146	R:R:L111	4.28	No	No	0	7	6
102	R:R:F112	R:R:S143	3.96	Yes	No	2	8	7
103	R:R:F112	R:R:I146	8.79	Yes	No	0	8	7
104	R:R:F112	R:R:W147	5.01	Yes	No	2	8	9
105	R:R:L113	R:R:N291	4.12	No	No	7	8	9
106	R:R:M203	R:R:T114	4.52	Yes	No	0	8	7
107	R:R:F115	R:R:I142	6.28	No	No	6	6	5
108	R:R:F115	R:R:I146	6.28	No	No	0	6	7
109	R:R:I116	R:R:R120	3.76	No	No	0	9	9
110	R:R:M203	R:R:S117	4.6	Yes	No	1	8	9
111	R:R:S117	R:R:Y207	6.36	No	Yes	1	9	9
112	R:R:F206	R:R:I118	7.54	No	No	0	8	6
113	R:R:R120	R:R:Y207	6.17	No	Yes	0	9	9
114	R:R:R120	R:R:Y295	6.17	No	No	0	9	9
115	R:R:K125	R:R:Y121	13.14	No	Yes	0	7	8
116	R:R:F206	R:R:Y121	8.25	No	Yes	0	8	8
117	R:R:K209	R:R:Y121	10.75	No	Yes	0	4	8
118	R:R:L122	R:R:Q134	5.32	No	No	0	5	7
119	R:R:I123	R:R:R129	7.52	No	No	0	8	5
120	R:R:F213	R:R:I124	6.28	No	No	0	5	8
121	R:R:K125	R:R:Y126	8.36	No	No	0	7	6
122	R:R:F128	R:R:P127	5.78	No	No	0	5	8
123	R:R:Q134	R:R:R129	4.67	No	No	0	7	5
124	R:R:H131	R:R:L132	16.71	No	No	0	4	4
125	R:R:H131	R:R:L133	7.71	No	No	0	4	3
126	R:R:H131	R:R:Q134	3.71	No	No	0	4	7
127	R:R:E137	R:R:K135	10.8	No	No	0	3	6
128	R:R:F138	R:R:I142	7.54	No	No	0	4	5
129	R:R:I157	R:R:L154	4.28	No	No	0	4	7
130	R:R:P156	R:R:Y187	9.74	No	Yes	0	8	5
131	R:R:I157	R:R:Y175	6.04	No	No	0	4	4
132	R:R:I157	R:R:Y187	6.04	No	Yes	0	4	5
133	R:R:L160	R:R:N184	6.87	No	Yes	0	5	3
134	R:R:D174	R:R:S177	5.89	No	No	0	5	4
135	R:R:N184	R:R:Y175	5.81	Yes	No	0	3	4
136	R:R:A176	R:R:Y277	4	No	Yes	0	6	5
137	R:R:R255	R:R:S177	3.95	No	No	0	5	4
138	R:R:D180	R:R:Y183	14.94	No	No	0	3	2
139	R:R:P181	R:R:R259	11.53	No	No	0	1	3
140	R:R:L260	R:R:P181	4.93	No	No	0	1	1
141	R:R:I256	R:R:N184	9.91	No	Yes	0	5	3
142	R:R:N184	R:R:R259	4.82	Yes	No	0	3	3
143	R:R:I256	R:R:L185	4.28	No	No	0	5	4
144	R:R:L191	R:R:Y187	4.69	No	Yes	0	5	5
145	R:R:R252	R:R:S188	7.91	Yes	No	0	6	5
146	R:R:N253	R:R:S188	7.45	No	No	0	6	5
147	R:R:H249	R:R:T192	6.85	Yes	No	0	8	6
148	R:R:N253	R:R:T192	8.77	No	No	0	6	6
149	R:R:L193	R:R:L197	4.15	No	No	0	5	4
150	R:R:F196	R:R:L197	3.65	Yes	No	0	8	4
151	R:R:F196	R:R:F241	4.29	Yes	Yes	1	8	9
152	R:R:F196	R:R:F245	4.29	Yes	Yes	1	8	8
153	R:R:F196	R:R:T246	3.89	Yes	No	0	8	5
154	R:R:F196	R:R:H249	20.36	Yes	Yes	1	8	8
155	R:R:F241	R:R:L200	4.87	Yes	No	0	9	6
156	R:R:L200	R:R:S242	4.5	No	No	0	6	6
157	R:R:M203	R:R:Y207	5.99	Yes	Yes	1	8	9
158	R:R:F241	R:R:M203	3.73	Yes	Yes	1	9	8
159	R:R:F205	R:R:K209	8.69	No	No	0	4	4
160	R:R:V234	R:R:Y207	6.31	No	Yes	0	8	9
161	R:R:A237	R:R:Y207	4	No	Yes	0	8	9
162	R:R:V238	R:R:Y207	5.05	No	Yes	0	8	9
163	R:R:L212	R:R:Y208	12.89	No	No	0	3	3
164	R:R:L221	R:R:R217	4.86	No	No	0	3	5
165	R:R:L225	R:R:N218	6.87	No	No	0	3	4
166	R:R:L227	R:R:N218	5.49	Yes	No	0	6	4
167	R:R:A224	R:R:P226	3.74	No	No	0	2	5
168	R:R:F294	R:R:M236	4.98	Yes	No	0	7	5
169	R:R:F294	R:R:I240	3.77	Yes	No	0	7	7
170	R:R:F241	R:R:F245	9.65	Yes	Yes	1	9	8
171	R:R:L244	R:R:N287	8.24	No	No	0	9	9
172	R:R:F245	R:R:N287	10.87	Yes	No	0	8	9
173	R:R:P247	R:R:T246	5.25	No	No	0	9	5
174	R:R:H249	R:R:Y248	5.44	Yes	Yes	1	8	7
175	R:R:R252	R:R:Y248	9.26	Yes	Yes	1	6	7
176	R:R:Y248	R:R:Y277	6.95	Yes	Yes	1	7	5
177	R:R:A284	R:R:Y248	5.34	No	Yes	0	8	7
178	R:R:H249	R:R:R252	4.51	Yes	Yes	1	8	6
179	R:R:F276	R:R:M251	3.73	No	No	0	5	4
180	R:R:M251	R:R:T280	7.53	No	No	0	4	7
181	R:R:R252	R:R:Y277	7.2	Yes	Yes	1	6	5
182	R:R:I273	R:R:V254	4.61	No	No	0	5	5
183	R:R:N274	R:R:R255	16.87	No	No	0	3	5
184	R:R:R255	R:R:Y277	7.2	No	Yes	0	5	5
185	R:R:Q270	R:R:S258	5.78	No	No	0	3	2
186	R:R:I273	R:R:S258	6.19	No	No	0	5	2
187	R:R:K264	R:R:Y266	29.86	No	No	0	3	5
188	R:R:Q265	R:R:Q267	6.4	No	No	0	1	7
189	R:R:Q265	R:R:T269	14.17	No	No	0	1	1
190	R:R:R281	R:R:Y277	9.26	No	Yes	0	6	5
191	R:R:I278	R:R:R281	3.76	No	No	0	4	6
192	R:R:I290	R:R:L286	5.71	No	No	0	6	5
193	R:R:N291	R:R:Y295	4.65	No	No	0	9	9
194	R:R:F294	R:R:Y295	8.25	Yes	No	0	7	9
195	R:R:D300	R:R:R303	4.76	No	No	0	5	8
196	R:R:E304	R:R:H301	11.08	No	No	0	4	6
197	R:R:F302	R:R:M305	3.73	Yes	No	0	8	4
198	R:R:K309	R:R:L306	7.05	No	No	0	5	7
199	R:R:I210	R:R:Y121	3.63	No	Yes	0	8	8
200	R:R:M251	R:R:Y277	3.59	No	Yes	0	4	5
201	R:R:G40	R:R:I43	3.53	No	No	0	8	6
202	R:R:L154	R:R:Y100	3.52	No	Yes	0	7	6
203	R:R:L122	R:R:Y121	3.52	No	Yes	0	5	8
204	R:R:P199	R:R:T114	3.5	No	No	0	8	7
205	R:R:L94	R:R:W88	3.42	No	Yes	0	6	8
206	R:R:I198	R:R:P199	3.39	No	No	0	6	8
207	R:R:K229	R:R:P230	3.35	No	No	0	7	7
208	R:R:L214	R:R:P230	3.28	No	No	0	7	7
209	R:R:L227	R:R:P226	3.28	Yes	No	0	6	5
210	R:R:L227	R:R:P230	3.28	Yes	No	0	6	7
211	R:R:S66	R:R:V45	3.23	No	No	0	9	8
212	R:R:C74	R:R:L70	3.17	No	No	0	5	8
213	R:R:C204	R:R:L200	3.17	No	No	0	5	6
214	R:R:A104	R:R:L154	3.15	No	No	0	5	7
215	R:R:A257	R:R:L185	3.15	No	No	0	4	4
216	R:R:R81	R:R:Y90	3.09	No	No	0	5	7
217	R:R:L260	R:R:S262	3	No	No	0	1	1
218	R:R:L144	R:R:V148	2.98	No	No	0	4	5
219	R:R:L297	R:R:V293	2.98	No	No	0	7	6
220	R:R:I161	R:R:I96	2.94	No	No	0	4	7
221	R:R:I140	R:R:K136	2.91	No	No	0	4	1
222	R:R:G195	R:R:Y107	2.9	No	Yes	0	6	7
223	R:R:E33	R:R:V289	2.85	Yes	No	0	7	8
224	R:R:L94	R:R:M78	2.83	No	No	0	6	7
225	R:R:G91	R:R:W88	2.81	No	Yes	0	8	8
226	R:R:L260	R:R:N182	2.75	No	No	0	1	1
227	R:R:N54	R:R:N56	2.72	No	Yes	0	6	7
228	R:R:K215	R:R:Q216	2.71	No	No	0	4	5
229	R:R:D180	R:R:N182	2.69	No	No	0	3	1
230	R:R:F206	R:R:V202	2.62	No	No	0	8	7
231	R:R:Q216	R:R:Q220	2.56	No	No	0	5	2
232	R:R:F213	R:R:L214	2.44	No	No	0	5	7
233	R:R:F294	R:R:L233	2.44	Yes	No	0	7	8
234	R:R:F302	R:R:L297	2.44	Yes	No	0	8	7
235	R:R:F302	R:R:L306	2.44	Yes	No	0	8	7
236	R:R:L227	R:R:R217	2.43	Yes	No	0	6	5
237	R:R:E137	R:R:F138	2.33	No	No	0	3	4
238	R:R:Q265	R:R:W263	2.19	No	No	0	1	1
239	R:R:G31	R:R:I80	1.76	No	No	0	5	6
240	R:R:P226	R:R:T223	1.75	No	No	0	5	4
241	R:R:G47	R:R:K309	1.74	No	No	0	7	5
242	R:R:C11	R:R:V271	1.71	No	No	0	7	2
243	R:R:A84	R:R:S27	1.71	No	No	0	5	5
244	R:R:G40	R:R:L39	1.71	No	No	0	8	4
245	R:R:G179	R:R:L160	1.71	No	No	0	1	5
246	R:R:G86	R:R:N85	1.7	No	No	0	4	3
247	R:R:G86	R:R:N87	1.7	No	No	0	4	4
248	R:R:C268	R:R:T10	1.69	No	No	0	1	9
249	R:R:L158	R:R:P159	1.64	No	No	0	4	4
250	R:R:C190	R:R:I186	1.64	No	No	0	4	4
251	R:R:S109	R:R:S68	1.63	No	Yes	0	9	8
252	R:R:N162	R:R:P159	1.63	No	No	0	4	4
253	R:R:N162	R:R:P163	1.63	No	No	0	4	5
254	R:R:A84	R:R:K23	1.61	No	No	0	5	4
255	R:R:V35	R:R:V36	1.6	No	No	0	4	6
256	R:R:V239	R:R:V243	1.6	No	No	0	5	6
257	R:R:V250	R:R:V254	1.6	No	No	0	7	5
258	R:R:T246	R:R:V250	1.59	No	No	0	5	7
259	R:R:A211	R:R:L231	1.58	No	No	0	5	6
260	R:R:I80	R:R:S27	1.55	No	No	0	6	5
261	R:R:I32	R:R:V36	1.54	No	No	0	6	6
262	R:R:I235	R:R:V234	1.54	No	No	0	4	8
263	R:R:I235	R:R:V239	1.54	No	No	0	4	5
264	R:R:A19	R:R:E22	1.51	No	No	0	5	5
265	R:R:F46	R:R:G47	1.51	No	No	0	4	7
266	R:R:L21	R:R:S275	1.5	No	No	0	4	1
267	R:R:L21	R:R:V279	1.49	No	No	0	4	5
268	R:R:L94	R:R:V93	1.49	No	No	0	6	2
269	R:R:I140	R:R:I60	1.47	No	No	0	4	7
270	R:R:I123	R:R:I124	1.47	No	No	0	8	8
271	R:R:I124	R:R:I210	1.47	No	No	0	8	8
272	R:R:N13	R:R:T10	1.46	No	No	0	6	9
273	R:R:D92	R:R:T171	1.45	No	No	0	2	3
274	R:R:I198	R:R:L194	1.43	No	No	0	6	5
275	R:R:M189	R:R:N253	1.4	No	No	0	5	6
276	R:R:M307	R:R:N308	1.4	No	No	0	4	4
277	R:R:P127	R:R:Y126	1.39	No	No	0	8	6
278	R:R:L152	R:R:L155	1.38	No	No	0	4	4
279	R:R:L244	R:R:L283	1.38	No	No	0	9	7
280	R:R:L70	R:R:N41	1.37	No	No	0	8	9
281	R:R:D174	R:R:N173	1.35	No	No	0	5	4
282	R:R:E153	R:R:L149	1.33	No	No	0	5	4
283	R:R:E153	R:R:L152	1.33	No	No	0	5	4
284	R:R:E153	R:R:L194	1.33	No	No	0	5	5
285	R:R:E228	R:R:N218	1.31	No	No	0	5	4
286	R:R:D300	R:R:E304	1.3	No	No	0	5	4
287	R:R:T151	R:R:Y100	1.25	No	Yes	0	4	6
288	R:R:S262	R:R:W263	1.24	No	No	0	1	1
289	R:R:M307	R:R:R303	1.24	No	No	0	4	8
290	R:R:F138	R:R:L141	1.22	No	No	0	4	2
291	R:R:F294	R:R:L298	1.22	Yes	No	0	7	6
292	R:R:I186	R:R:Y183	1.21	No	No	0	4	2
293	R:R:I186	R:R:Y187	1.21	No	Yes	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.86	8	3	0
2	R:R:Y30	6.19667	6	3	8
3	R:R:E33	5.7875	4	0	7
4	R:R:Y48	6.566	5	5	7
5	R:R:N56	7.4975	4	0	7
6	R:R:Y61	4.9075	4	6	7
7	R:R:F63	6.078	5	5	6
8	R:R:S68	4.3325	4	2	8
9	R:R:F72	7.3125	4	0	7
10	R:R:W88	7.845	6	8	8
11	R:R:Y100	3.83	4	0	6
12	R:R:Y107	4.6025	4	1	7
13	R:R:F112	7.1575	4	2	8
14	R:R:Y121	7.858	5	0	8
15	R:R:N184	6.8525	4	0	3
16	R:R:Y187	5.42	4	0	5
17	R:R:F196	7.296	5	1	8
18	R:R:M203	4.71	4	1	8
19	R:R:Y207	5.64667	6	1	9
20	R:R:L227	3.62	4	0	6
21	R:R:F241	5.262	5	1	9
22	R:R:F245	8.204	5	1	8
23	R:R:Y248	6.7475	4	1	7
24	R:R:H249	8.304	5	1	8
25	R:R:R252	6.6	5	1	6
26	R:R:Y277	6.36667	6	1	5
27	R:R:F294	4.132	5	0	7
28	R:R:F302	3.4425	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y30	38.8092	5.2	Yes	Yes	3	0	8
2	R:R:F285	R:R:Y30	27.5831	7.22	No	Yes	0	7	8
3	R:R:E33	R:R:F285	28.3893	5.83	Yes	No	0	7	7
4	R:R:E33	R:R:F29	17.126	10.49	Yes	No	0	7	5
5	R:R:F29	R:R:Y25	14.5117	9.28	No	No	4	5	4
6	R:R:V279	R:R:Y25	13.2501	6.31	No	No	0	5	4
7	R:R:L21	R:R:V279	11.9379	1.49	No	No	0	4	5
8	R:R:L21	R:R:S275	10.6224	1.5	No	No	0	4	1
9	L:L:?1	R:R:R281	84.2604	22.65	Yes	No	0	0	6
10	R:R:R281	R:R:Y277	85.8256	9.26	No	Yes	0	6	5
11	R:R:R255	R:R:Y277	10.7573	7.2	No	Yes	0	5	5
12	L:L:?1	R:R:L102	41.3088	3.69	Yes	No	0	0	7
13	R:R:F72	R:R:L102	23.8759	6.09	Yes	No	0	7	7
14	R:R:F72	R:R:L73	11.7794	6.09	Yes	No	0	7	6
15	R:R:D69	R:R:L73	10.4976	4.07	No	No	0	9	6
16	R:R:D69	R:R:N41	18.391	14.81	No	No	0	9	9
17	R:R:N41	R:R:P292	10.5482	4.89	No	No	0	9	9
18	R:R:F72	R:R:S288	11.7794	5.28	Yes	No	0	7	9
19	R:R:D69	R:R:S288	10.4976	10.31	No	No	0	9	9
20	R:R:Y248	R:R:Y277	43.4475	6.95	Yes	Yes	1	7	5
21	R:R:H249	R:R:Y248	43.9062	5.44	Yes	Yes	1	8	7
22	R:R:F196	R:R:H249	100	20.36	Yes	Yes	1	8	8
23	R:R:F196	R:R:F241	90.8922	4.29	Yes	Yes	1	8	9
24	R:R:F241	R:R:M203	90.4368	3.73	Yes	Yes	1	9	8
25	R:R:M203	R:R:Y207	89.9545	5.99	Yes	Yes	1	8	9
26	R:R:R120	R:R:Y207	86.1359	6.17	No	Yes	0	9	9
27	R:R:I116	R:R:R120	79.8752	3.76	No	No	0	9	9
28	R:R:I116	R:R:L62	79.1972	5.71	No	No	0	9	8
29	R:R:F296	R:R:L62	78.4989	9.74	No	No	0	6	8
30	R:R:R252	R:R:Y277	53.294	7.2	Yes	Yes	1	6	5
31	R:R:H249	R:R:R252	43.7005	4.51	Yes	Yes	1	8	6
32	R:R:F296	R:R:Y48	77.1361	5.16	No	Yes	0	6	7
33	R:R:F302	R:R:Y48	12.0256	5.16	Yes	Yes	0	8	7
34	R:R:N59	R:R:Y48	63.5183	10.47	No	Yes	0	7	7
35	R:R:N56	R:R:N59	62.7087	9.54	Yes	No	0	7	7
36	R:R:N56	R:R:S58	30.7607	4.47	Yes	No	0	7	8
37	R:R:N56	R:R:R129	36.0229	13.26	Yes	No	0	7	5
38	R:R:D119	R:R:S58	29.6913	5.89	No	No	0	8	8
39	R:R:D119	R:R:Y61	27.5527	4.6	No	Yes	0	8	7
40	R:R:F115	R:R:Y61	16.3839	6.19	No	Yes	6	6	7
41	R:R:F115	R:R:I146	15.4664	6.28	No	No	0	6	7
42	R:R:F112	R:R:I146	13.2434	8.79	Yes	No	0	8	7
43	R:R:R120	R:R:Y295	10.6359	6.17	No	No	0	9	9
44	R:R:L102	R:R:T75	20.9917	4.42	No	No	0	7	6
45	R:R:N98	R:R:T75	19.7301	7.31	No	No	0	4	6
46	R:R:M78	R:R:N98	18.4618	7.01	No	No	0	7	4
47	R:R:L94	R:R:M78	17.1867	2.83	No	No	0	6	7
48	R:R:L94	R:R:W88	14.6163	3.42	No	Yes	0	6	8
49	L:L:?1	R:R:R99	10.0084	14.02	Yes	No	0	0	6
50	R:R:L191	R:R:Y107	21.4201	7.03	No	Yes	0	5	7
51	R:R:Q134	R:R:R129	17.2542	4.67	No	No	0	7	5
52	R:R:L122	R:R:Q134	12.6666	5.32	No	No	0	5	7
53	R:R:L122	R:R:Y121	11.5972	3.52	No	Yes	0	5	8
54	R:R:I123	R:R:R129	18.1616	7.52	No	No	0	8	5
55	R:R:I123	R:R:I124	17.0923	1.47	No	No	0	8	8
56	R:R:L191	R:R:Y187	20.759	4.69	No	Yes	0	5	5
57	R:R:I157	R:R:Y187	11.0204	6.04	No	Yes	0	4	5
58	R:R:F213	R:R:I124	15.3618	6.28	No	No	0	5	8
59	R:R:F213	R:R:L214	14.306	2.44	No	No	0	5	7
60	R:R:L214	R:R:P230	13.1354	3.28	No	No	0	7	7
61	R:R:L227	R:R:P230	10.8889	3.28	Yes	No	0	6	7
62	R:R:H249	R:R:Y107	12.9263	4.36	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y30	5.2	3	Yes	Yes	0	8	0	1
L:L:?1	R:R:L79	6.14	3	Yes	No	0	6	0	1
L:L:?1	R:R:Y83	6.24	3	Yes	No	0	5	0	1
L:L:?1	R:R:R99	14.02	3	Yes	No	0	6	0	1
L:L:?1	R:R:L102	3.69	3	Yes	No	0	7	0	1
L:L:?1	R:R:H103	5.71	3	Yes	No	0	5	0	1
L:L:?1	R:R:D174	7.23	3	Yes	No	0	5	0	1
L:L:?1	R:R:R281	22.65	3	Yes	No	0	6	0	1
R:R:L26	R:R:Y30	5.86	0	No	Yes	6	8	2	1
R:R:L76	R:R:Y30	7.03	0	No	Yes	8	8	2	1
R:R:L79	R:R:Y30	7.03	3	No	Yes	6	8	1	1
R:R:I80	R:R:Y30	4.84	0	No	Yes	6	8	2	1
R:R:F285	R:R:Y30	7.22	0	No	Yes	7	8	2	1
R:R:F72	R:R:L102	6.09	0	Yes	No	7	7	2	1
R:R:F285	R:R:F72	11.79	0	No	Yes	7	7	2	2
R:R:L102	R:R:T75	4.42	0	No	No	7	6	1	2
R:R:L79	R:R:Y83	5.86	3	No	No	6	5	1	1
R:R:I161	R:R:R99	3.76	0	No	No	4	6	2	1
R:R:D174	R:R:S177	5.89	0	No	No	5	4	1	2
R:R:R281	R:R:Y277	9.26	0	No	Yes	6	5	1	2
R:R:I278	R:R:R281	3.76	0	No	No	4	6	2	1
R:R:D174	R:R:N173	1.35	0	No	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JPN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	277
Number of Links	293
Number of Hubs	28
Number of Links mediated by Hubs	117
Number of Communities	8
Number of Nodes involved in Communities	37
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	49018
Length Of Smallest Path	3
Average Path Length	17.1719
Length of Longest Path	40
Minimum Path Strength	1.21
Average Path Strength	6.96577
Maximum Path Strength	18.335
Minimum Path Correlation	0.7
Average Path Correlation	0.930194
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	41.57
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.4989
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U9S
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U9S
Name	(2R,3S)-oxirane-2,3-dicarboxylic acid
Synonyms	cis-2,3-epoxysuccinic acid
Identifier
Formula	C4 H4 O5
Molecular Weight	132.072
SMILES
PubChem	2734802
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	2
Total Bonds	13
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXA5
Sequence	>8JPN_nogp_Chain_R T C K N W L A A E A A L E K Y Y L S I F Y G I E F V V G V L G N T I V V F G Y L F C L K N W N S S N I Y L F N L S I S D L A F L C T L P M L I R S Y A N G N W I Y G D V L C I S N R Y V L H A N L Y T S I L F L T F I S I D R Y L I I K Y P F R E H L L Q K K E F A I L I S L A I W V L V T L E L L P I L P L I N P T C N D Y A S S G D P N Y N L I Y S M C L T L L G F L I P L F V M C F F Y Y K I A L F L K Q R N R Q L A T A L P L E K P L N L V I M A V V I F S V L F T P Y H V M R N V R I A S R L G S W K Q Y Q C T Q V V I N S F Y I V T R P L A F L N S V I N P V F Y F L L G D H F R E M L M N K L R H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6Z10	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	PubChem 154585554	-	-	2.27	2020-09-16	doi.org/10.1021/acs.jmedchem.0c01020
	8JPN	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ1	2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPN (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	chim(Gs-CtGq)/β1/γ1	3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8YKW	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ1	2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKW (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-	Gi1/β1/γ1	2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-		2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	6IBB	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	-	-	-	2.12	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	6RNK	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	NF-56-EJ40	-	-	1.94	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	8WOG	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ2	2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WOG (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ2	3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1 (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8YKV	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-	Gi1/β1/γ2	2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKV (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-		2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JPN_nogp.zip

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