psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y30	5.03	Yes	Yes	1	0	8
2	L:L:?1	R:R:L79	9.91	Yes	No	1	0	6
3	L:L:?1	R:R:Y83	9.23	Yes	No	1	0	5
4	L:L:?1	R:R:W88	8.97	Yes	Yes	1	0	8
5	L:L:?1	R:R:N98	4.91	Yes	No	0	0	4
6	L:L:?1	R:R:R99	13.04	Yes	Yes	0	0	6
7	L:L:?1	R:R:L102	12.88	Yes	Yes	1	0	7
8	L:L:?1	R:R:H103	11.04	Yes	Yes	1	0	5
9	L:L:?1	R:R:D174	4.86	Yes	Yes	1	0	5
10	L:L:?1	R:R:R281	6.96	Yes	Yes	1	0	6
11	R:R:V272	R:R:W14	7.36	No	No	0	3	5
12	R:R:E18	R:R:E22	13.95	No	No	0	5	5
13	R:R:E18	R:R:N274	3.94	No	No	0	5	3
14	R:R:L21	R:R:Y25	5.86	No	Yes	0	4	4
15	R:R:E22	R:R:I278	4.1	No	Yes	0	5	4
16	R:R:G86	R:R:K23	3.49	No	No	0	4	4
17	R:R:I28	R:R:Y24	13.3	No	No	0	6	3
18	R:R:F29	R:R:Y25	13.41	No	Yes	0	5	4
19	R:R:P282	R:R:Y25	5.56	No	Yes	0	5	4
20	R:R:L26	R:R:Y30	8.21	Yes	Yes	1	6	8
21	R:R:L26	R:R:Y83	12.89	Yes	No	1	6	5
22	R:R:I278	R:R:L26	4.28	Yes	Yes	0	4	6
23	R:R:L26	R:R:P282	3.28	Yes	No	1	6	5
24	R:R:L76	R:R:Y30	5.86	No	Yes	0	8	8
25	R:R:L79	R:R:Y30	9.38	No	Yes	1	6	8
26	R:R:I80	R:R:Y30	3.63	No	Yes	0	6	8
27	R:R:R281	R:R:Y30	4.12	Yes	Yes	1	6	8
28	R:R:P282	R:R:Y30	8.34	No	Yes	1	5	8
29	R:R:F285	R:R:Y30	7.22	Yes	Yes	1	7	8
30	R:R:G31	R:R:I80	3.53	No	No	0	5	6
31	R:R:E33	R:R:L286	5.3	No	No	0	7	5
32	R:R:F34	R:R:V38	6.55	No	No	0	7	6
33	R:R:F34	R:R:L76	3.65	No	No	0	7	8
34	R:R:F34	R:R:P77	13	No	No	0	7	8
35	R:R:G37	R:R:V289	3.68	No	No	0	8	8
36	R:R:L70	R:R:V38	4.47	No	No	0	8	6
37	R:R:G40	R:R:I43	3.53	No	No	0	8	6
38	R:R:D69	R:R:N41	4.04	Yes	No	0	9	9
39	R:R:L70	R:R:N41	6.87	No	No	0	8	9
40	R:R:N41	R:R:P292	8.15	No	No	0	9	9
41	R:R:P292	R:R:V44	5.3	No	No	0	9	9
42	R:R:F296	R:R:V44	7.87	Yes	No	0	6	9
43	R:R:F63	R:R:W55	7.02	No	No	0	6	6
44	R:R:N56	R:R:N59	8.17	No	No	0	7	7
45	R:R:N56	R:R:R129	12.05	No	Yes	0	7	5
46	R:R:D119	R:R:S57	7.36	No	No	0	8	6
47	R:R:D119	R:R:S58	7.36	No	No	0	8	8
48	R:R:R129	R:R:S58	5.27	Yes	No	0	5	8
49	R:R:I60	R:R:N64	4.25	Yes	Yes	0	7	9
50	R:R:A139	R:R:I60	6.5	No	Yes	0	7	7
51	R:R:F115	R:R:Y61	7.22	Yes	Yes	6	6	7
52	R:R:D119	R:R:Y61	6.9	No	Yes	0	8	7
53	R:R:A139	R:R:Y61	5.34	No	Yes	0	7	7
54	R:R:I142	R:R:Y61	7.25	No	Yes	6	5	7
55	R:R:I116	R:R:L62	7.14	No	No	0	9	8
56	R:R:L62	R:R:Y295	3.52	No	Yes	0	8	9
57	R:R:F63	R:R:N64	6.04	No	Yes	0	6	9
58	R:R:F63	R:R:V67	7.87	No	No	0	6	7
59	R:R:F112	R:R:N64	13.29	Yes	Yes	2	8	9
60	R:R:N64	R:R:S143	5.96	Yes	No	2	9	7
61	R:R:D69	R:R:L65	5.43	Yes	Yes	3	9	9
62	R:R:L113	R:R:L65	6.92	No	Yes	3	8	9
63	R:R:I116	R:R:L65	4.28	No	Yes	0	9	9
64	R:R:L65	R:R:N291	6.87	Yes	Yes	3	9	9
65	R:R:L65	R:R:Y295	3.52	Yes	Yes	3	9	9
66	R:R:S68	R:R:T108	6.4	No	Yes	2	8	7
67	R:R:S68	R:R:W147	7.41	No	No	2	8	9
68	R:R:D69	R:R:S109	8.83	Yes	No	0	9	9
69	R:R:D69	R:R:S288	5.89	Yes	No	0	9	9
70	R:R:D69	R:R:N291	8.08	Yes	Yes	3	9	9
71	R:R:A71	R:R:N105	4.69	No	No	0	6	8
72	R:R:F72	R:R:L102	9.74	Yes	Yes	0	7	7
73	R:R:F72	R:R:N105	6.04	Yes	No	0	7	8
74	R:R:F72	R:R:L106	3.65	Yes	No	0	7	8
75	R:R:F285	R:R:F72	11.79	Yes	Yes	0	7	7
76	R:R:F72	R:R:S288	3.96	Yes	No	0	7	9
77	R:R:L73	R:R:S288	7.51	No	No	0	6	9
78	R:R:N98	R:R:T75	8.77	No	No	0	4	6
79	R:R:L102	R:R:T75	7.37	Yes	No	0	7	6
80	R:R:M78	R:R:W88	4.65	No	Yes	1	7	8
81	R:R:M78	R:R:Y90	10.78	No	Yes	1	7	7
82	R:R:M78	R:R:N98	9.82	No	No	0	7	4
83	R:R:L79	R:R:Y83	5.86	No	No	1	6	5
84	R:R:A84	R:R:R81	5.53	No	No	0	5	5
85	R:R:N85	R:R:R81	15.67	No	No	0	3	5
86	R:R:S82	R:R:W88	8.65	No	Yes	0	5	8
87	R:R:W88	R:R:Y90	11.58	Yes	Yes	1	8	7
88	R:R:C95	R:R:W88	6.53	No	Yes	0	9	8
89	R:R:I89	R:R:Y90	4.84	No	Yes	0	3	7
90	R:R:D92	R:R:V93	4.38	No	No	0	2	2
91	R:R:C95	R:R:R99	4.18	No	Yes	0	9	6
92	R:R:I157	R:R:R99	3.76	Yes	Yes	0	4	6
93	R:R:T151	R:R:Y100	6.24	No	Yes	0	4	6
94	R:R:L154	R:R:Y100	5.86	No	Yes	0	7	6
95	R:R:L155	R:R:Y100	3.52	No	Yes	0	4	6
96	R:R:I157	R:R:Y100	3.63	Yes	Yes	0	4	6
97	R:R:L158	R:R:Y100	7.03	No	Yes	0	4	6
98	R:R:N105	R:R:V101	4.43	No	No	0	8	5
99	R:R:H103	R:R:L102	3.86	Yes	Yes	1	5	7
100	R:R:H103	R:R:I157	3.98	Yes	Yes	1	5	4
101	R:R:F175	R:R:H103	5.66	Yes	Yes	1	4	5
102	R:R:L106	R:R:Y107	7.03	No	Yes	0	8	7
103	R:R:L191	R:R:Y107	10.55	Yes	Yes	1	5	7
104	R:R:H249	R:R:Y107	9.8	Yes	Yes	1	8	7
105	R:R:R252	R:R:Y107	5.14	Yes	Yes	1	6	7
106	R:R:F112	R:R:T108	3.89	Yes	Yes	2	8	7
107	R:R:T108	R:R:W147	10.92	Yes	No	2	7	9
108	R:R:T108	R:R:V150	7.93	Yes	No	0	7	8
109	R:R:I110	R:R:P199	3.39	No	Yes	0	8	8
110	R:R:F241	R:R:I110	6.28	Yes	No	1	9	8
111	R:R:F245	R:R:I110	13.82	Yes	No	1	8	8
112	R:R:I146	R:R:L111	7.14	No	No	0	7	6
113	R:R:L111	R:R:P199	3.28	No	Yes	0	6	8
114	R:R:F112	R:R:S143	5.28	Yes	No	2	8	7
115	R:R:F112	R:R:I146	8.79	Yes	No	0	8	7
116	R:R:F112	R:R:W147	7.02	Yes	No	2	8	9
117	R:R:L113	R:R:N291	6.87	No	Yes	3	8	9
118	R:R:L113	R:R:Y295	7.03	No	Yes	3	8	9
119	R:R:P199	R:R:T114	6.99	Yes	No	0	8	7
120	R:R:F115	R:R:I118	3.77	Yes	No	0	6	6
121	R:R:F115	R:R:I142	8.79	Yes	No	6	6	5
122	R:R:F115	R:R:I146	7.54	Yes	No	0	6	7
123	R:R:I116	R:R:R120	3.76	No	No	0	9	9
124	R:R:M203	R:R:S117	4.6	No	No	1	8	9
125	R:R:S117	R:R:Y207	10.17	No	Yes	1	9	9
126	R:R:F206	R:R:I118	6.28	No	No	0	8	6
127	R:R:R120	R:R:Y207	8.23	No	Yes	0	9	9
128	R:R:R120	R:R:Y295	7.2	No	Yes	0	9	9
129	R:R:K125	R:R:Y121	10.75	No	Yes	0	7	8
130	R:R:F206	R:R:Y121	10.32	No	Yes	0	8	8
131	R:R:K209	R:R:Y121	7.17	No	Yes	0	4	8
132	R:R:I210	R:R:Y121	4.84	No	Yes	0	8	8
133	R:R:L122	R:R:L133	4.15	No	No	0	5	3
134	R:R:L122	R:R:Q134	5.32	No	Yes	0	5	7
135	R:R:I123	R:R:R129	10.02	No	Yes	4	8	5
136	R:R:I123	R:R:Q134	4.12	No	Yes	4	8	7
137	R:R:F213	R:R:I124	13.82	No	No	0	5	8
138	R:R:K125	R:R:Y126	5.97	No	Yes	0	7	6
139	R:R:E130	R:R:Y126	6.73	No	Yes	0	5	6
140	R:R:H131	R:R:Y126	14.16	Yes	Yes	4	4	6
141	R:R:Q134	R:R:Y126	5.64	Yes	Yes	4	7	6
142	R:R:E130	R:R:F128	11.66	No	No	0	5	5
143	R:R:Q134	R:R:R129	8.18	Yes	Yes	4	7	5
144	R:R:H131	R:R:L133	7.71	Yes	No	0	4	3
145	R:R:H131	R:R:Q134	4.95	Yes	Yes	4	4	7
146	R:R:F138	R:R:L132	8.53	No	No	0	4	4
147	R:R:E153	R:R:L191	3.98	No	Yes	0	5	5
148	R:R:P156	R:R:Y183	4.17	No	No	0	8	2
149	R:R:P156	R:R:Y187	15.3	No	No	0	8	5
150	R:R:F175	R:R:I157	7.54	Yes	Yes	1	4	4
151	R:R:G179	R:R:L160	5.13	No	No	0	1	5
152	R:R:D174	R:R:S177	10.31	Yes	No	0	5	4
153	R:R:D174	R:R:R281	3.57	Yes	Yes	1	5	6
154	R:R:F175	R:R:N184	12.08	Yes	No	0	4	3
155	R:R:F175	R:R:Y187	4.13	Yes	No	0	4	5
156	R:R:F175	R:R:S188	3.96	Yes	No	1	4	5
157	R:R:F175	R:R:R252	5.34	Yes	Yes	1	4	6
158	R:R:A176	R:R:Y277	5.34	No	Yes	0	6	5
159	R:R:R255	R:R:S177	5.27	Yes	No	0	5	4
160	R:R:D180	R:R:P181	8.05	No	No	0	3	1
161	R:R:D180	R:R:N182	9.42	No	No	0	3	1
162	R:R:D180	R:R:Y183	3.45	No	No	0	3	2
163	R:R:P181	R:R:R259	5.76	No	No	0	1	3
164	R:R:L260	R:R:P181	4.93	No	No	0	1	1
165	R:R:L260	R:R:N182	8.24	No	No	0	1	1
166	R:R:I256	R:R:N184	9.91	No	No	0	5	3
167	R:R:I256	R:R:L185	7.14	No	No	0	5	4
168	R:R:L191	R:R:Y187	7.03	Yes	No	0	5	5
169	R:R:R252	R:R:S188	9.22	Yes	No	1	6	5
170	R:R:N253	R:R:S188	8.94	No	No	0	6	5
171	R:R:M189	R:R:N253	9.82	No	No	0	5	6
172	R:R:L191	R:R:R252	3.64	Yes	Yes	1	5	6
173	R:R:H249	R:R:T192	8.21	Yes	No	0	8	6
174	R:R:N253	R:R:T192	7.31	No	No	0	6	6
175	R:R:G195	R:R:P199	4.06	No	Yes	0	6	8
176	R:R:F196	R:R:L197	4.87	Yes	No	0	8	4
177	R:R:F196	R:R:L200	4.87	Yes	No	1	8	6
178	R:R:F196	R:R:F241	5.36	Yes	Yes	1	8	9
179	R:R:F196	R:R:F245	4.29	Yes	Yes	1	8	8
180	R:R:F196	R:R:T246	6.49	Yes	No	0	8	5
181	R:R:F196	R:R:H249	27.15	Yes	Yes	1	8	8
182	R:R:I198	R:R:P199	3.39	No	Yes	0	6	8
183	R:R:F241	R:R:L200	4.87	Yes	No	1	9	6
184	R:R:M203	R:R:Y207	4.79	No	Yes	1	8	9
185	R:R:F241	R:R:M203	11.2	Yes	No	1	9	8
186	R:R:F205	R:R:F206	9.65	No	No	0	4	8
187	R:R:F205	R:R:K209	8.69	No	No	0	4	4
188	R:R:V234	R:R:Y207	8.83	No	Yes	0	8	9
189	R:R:A237	R:R:Y207	4	No	Yes	0	8	9
190	R:R:V238	R:R:Y207	5.05	No	Yes	0	8	9
191	R:R:K209	R:R:Y208	3.58	No	No	0	4	3
192	R:R:L212	R:R:Y208	15.24	No	No	0	3	3
193	R:R:F213	R:R:R217	8.55	No	No	0	5	5
194	R:R:L214	R:R:P230	3.28	No	No	0	7	7
195	R:R:K215	R:R:L231	7.05	No	No	0	4	6
196	R:R:Q220	R:R:R217	7.01	No	No	0	2	5
197	R:R:N218	R:R:P226	4.89	No	Yes	0	4	5
198	R:R:P226	R:R:R219	12.97	Yes	No	0	5	4
199	R:R:L225	R:R:P226	3.28	No	Yes	0	3	5
200	R:R:E228	R:R:P226	9.43	No	Yes	0	5	5
201	R:R:K229	R:R:P230	3.35	No	No	0	7	7
202	R:R:K229	R:R:L233	4.23	No	No	0	7	8
203	R:R:L233	R:R:L298	4.15	No	No	0	8	6
204	R:R:F294	R:R:M236	3.73	No	No	0	7	5
205	R:R:F241	R:R:F245	10.72	Yes	Yes	1	9	8
206	R:R:L244	R:R:N287	10.98	No	No	0	9	9
207	R:R:F245	R:R:H249	5.66	Yes	Yes	1	8	8
208	R:R:F245	R:R:N287	16.92	Yes	No	0	8	9
209	R:R:P247	R:R:T246	3.5	No	No	0	9	5
210	R:R:P247	R:R:T280	3.5	No	No	0	9	7
211	R:R:H249	R:R:Y248	5.44	Yes	Yes	1	8	7
212	R:R:R252	R:R:Y248	9.26	Yes	Yes	1	6	7
213	R:R:Y248	R:R:Y277	8.94	Yes	Yes	1	7	5
214	R:R:R281	R:R:Y248	5.14	Yes	Yes	1	6	7
215	R:R:A284	R:R:Y248	6.67	No	Yes	0	8	7
216	R:R:F285	R:R:Y248	6.19	Yes	Yes	1	7	7
217	R:R:H249	R:R:R252	4.51	Yes	Yes	1	8	6
218	R:R:M251	R:R:V254	4.56	No	No	0	4	5
219	R:R:M251	R:R:T280	7.53	No	No	0	4	7
220	R:R:R252	R:R:Y277	10.29	Yes	Yes	1	6	5
221	R:R:I273	R:R:V254	6.14	Yes	No	0	5	5
222	R:R:R255	R:R:S258	3.95	Yes	No	0	5	2
223	R:R:R255	R:R:R259	8.53	Yes	No	0	5	3
224	R:R:N274	R:R:R255	18.08	No	Yes	0	3	5
225	R:R:R255	R:R:Y277	6.17	Yes	Yes	0	5	5
226	R:R:I273	R:R:S258	4.64	Yes	No	0	5	2
227	R:R:I278	R:R:N274	8.5	Yes	No	0	4	3
228	R:R:R281	R:R:Y277	18.52	Yes	Yes	1	6	5
229	R:R:I278	R:R:R281	3.76	Yes	Yes	0	4	6
230	R:R:F285	R:R:R281	6.41	Yes	Yes	1	7	6
231	R:R:L286	R:R:V289	4.47	No	No	0	5	8
232	R:R:I290	R:R:L286	5.71	No	No	0	6	5
233	R:R:N287	R:R:N291	6.81	No	Yes	0	9	9
234	R:R:N291	R:R:Y295	5.81	Yes	Yes	3	9	9
235	R:R:L297	R:R:V293	7.45	No	No	0	7	6
236	R:R:F294	R:R:Y295	8.25	No	Yes	0	7	9
237	R:R:F296	R:R:F302	12.86	Yes	No	5	6	8
238	R:R:F296	R:R:L306	4.87	Yes	No	0	6	7
239	R:R:D300	R:R:R303	7.15	No	No	0	5	8
240	R:R:C190	R:R:I186	3.27	No	No	0	4	4
241	R:R:S66	R:R:V45	3.23	No	No	0	9	8
242	R:R:T114	R:R:V202	3.17	No	No	0	7	7
243	R:R:C204	R:R:L200	3.17	No	No	0	5	6
244	R:R:A257	R:R:L185	3.15	No	No	0	4	4
245	R:R:L21	R:R:S275	3	No	No	0	4	1
246	R:R:L152	R:R:V148	2.98	No	No	0	4	5
247	R:R:I140	R:R:I60	2.94	No	Yes	0	4	7
248	R:R:I60	R:R:K136	2.91	Yes	No	0	7	1
249	R:R:F128	R:R:P127	2.89	No	No	0	5	8
250	R:R:I140	R:R:L144	2.85	No	No	0	4	4
251	R:R:I210	R:R:L214	2.85	No	No	0	8	7
252	R:R:I235	R:R:L231	2.85	No	No	0	4	6
253	R:R:I240	R:R:L244	2.85	No	No	0	7	9
254	R:R:K135	R:R:L132	2.82	No	No	0	6	4
255	R:R:G91	R:R:W88	2.81	No	Yes	0	8	8
256	R:R:L193	R:R:L194	2.77	No	No	0	5	5
257	R:R:L214	R:R:L227	2.77	No	No	0	7	6
258	R:R:L227	R:R:N218	2.75	No	No	0	6	4
259	R:R:A104	R:R:Y100	2.67	No	Yes	0	5	6
260	R:R:L212	R:R:Q216	2.66	No	No	0	3	5
261	R:R:E153	R:R:L149	2.65	No	No	0	5	4
262	R:R:E153	R:R:L194	2.65	No	No	0	5	5
263	R:R:H301	R:R:M305	2.63	No	No	0	6	4
264	R:R:S27	R:R:Y24	2.54	No	No	0	5	3
265	R:R:I96	R:R:R99	2.51	No	Yes	0	7	6
266	R:R:F276	R:R:M251	2.49	No	No	0	5	4
267	R:R:F296	R:R:M305	2.49	Yes	No	5	6	4
268	R:R:F302	R:R:M305	2.49	No	No	5	8	4
269	R:R:F296	R:R:L297	2.44	Yes	No	0	6	7
270	R:R:L94	R:R:Y90	2.34	No	Yes	0	6	7
271	R:R:R81	R:R:Y90	2.06	No	Yes	0	5	7
272	R:R:G40	R:R:P292	2.03	No	No	0	8	9
273	R:R:G179	R:R:S178	1.86	No	No	0	1	3
274	R:R:G37	R:R:V36	1.84	No	No	0	8	6
275	R:R:C11	R:R:C268	1.82	No	No	0	7	1
276	R:R:A84	R:R:S27	1.71	No	No	0	5	5
277	R:R:G37	R:R:L73	1.71	No	No	0	8	6
278	R:R:G40	R:R:L39	1.71	No	No	0	8	4
279	R:R:G261	R:R:L260	1.71	No	No	0	2	1
280	R:R:C268	R:R:V271	1.71	No	No	0	1	2
281	R:R:A211	R:R:V234	1.7	No	No	0	5	8
282	R:R:A224	R:R:V221	1.7	No	No	0	2	3
283	R:R:D92	R:R:G91	1.68	No	No	0	2	8
284	R:R:L158	R:R:P159	1.64	No	No	0	4	4
285	R:R:S66	R:R:V44	1.62	No	No	0	9	9
286	R:R:S66	R:R:V67	1.62	No	No	0	9	7
287	R:R:S97	R:R:V101	1.62	No	No	0	5	5
288	R:R:V238	R:R:V239	1.6	No	No	0	8	5
289	R:R:V239	R:R:V243	1.6	No	No	0	5	6
290	R:R:S242	R:R:T246	1.6	No	No	0	6	5
291	R:R:V250	R:R:V254	1.6	No	No	0	7	5
292	R:R:V271	R:R:V272	1.6	No	No	0	2	3
293	R:R:T280	R:R:V279	1.59	No	No	0	7	5
294	R:R:A211	R:R:L231	1.58	No	No	0	5	6
295	R:R:I273	R:R:V272	1.54	Yes	No	0	5	3
296	R:R:I43	R:R:T42	1.52	No	No	0	6	4
297	R:R:I273	R:R:T269	1.52	Yes	No	0	5	1
298	R:R:A19	R:R:E18	1.51	No	No	0	5	5
299	R:R:L15	R:R:V271	1.49	No	No	0	7	2
300	R:R:L39	R:R:V35	1.49	No	No	0	4	4
301	R:R:I124	R:R:I210	1.47	No	No	0	8	8
302	R:R:D174	R:R:S178	1.47	Yes	No	0	5	3
303	R:R:Q270	R:R:S258	1.44	No	No	0	3	2
304	R:R:I142	R:R:L141	1.43	No	No	0	5	2
305	R:R:K12	R:R:N13	1.4	No	No	0	4	6
306	R:R:D300	R:R:K229	1.38	No	No	0	5	7
307	R:R:H131	R:R:L132	1.29	Yes	No	0	4	4
308	R:R:F29	R:R:I32	1.26	No	No	0	5	6
309	R:R:F201	R:R:L197	1.22	No	No	0	3	4
310	R:R:L283	R:R:Y25	1.17	No	Yes	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.683	10	1	0
2	R:R:Y25	6.5	4	0	4
3	R:R:L26	7.165	4	1	6
4	R:R:Y30	6.47375	8	1	8
5	R:R:I60	4.15	4	0	7
6	R:R:Y61	6.6775	4	6	7
7	R:R:N64	7.385	4	2	9
8	R:R:L65	5.404	5	3	9
9	R:R:D69	6.454	5	3	9
10	R:R:F72	7.036	5	0	7
11	R:R:W88	7.19833	6	1	8
12	R:R:Y90	6.32	5	1	7
13	R:R:R99	5.8725	4	0	6
14	R:R:Y100	4.825	6	0	6
15	R:R:L102	8.4625	4	1	7
16	R:R:H103	6.135	4	1	5
17	R:R:Y107	8.13	4	1	7
18	R:R:T108	7.285	4	2	7
19	R:R:F112	7.654	5	2	8
20	R:R:F115	6.83	4	6	6
21	R:R:Y121	8.27	4	0	8
22	R:R:Y126	8.125	4	4	6
23	R:R:R129	8.88	4	4	5
24	R:R:H131	7.0275	4	4	4
25	R:R:Q134	5.642	5	4	7
26	R:R:I157	4.7275	4	1	4
27	R:R:D174	5.0525	4	1	5
28	R:R:F175	6.45167	6	1	4
29	R:R:L191	6.3	4	1	5
30	R:R:F196	8.83833	6	1	8
31	R:R:P199	4.222	5	0	8
32	R:R:Y207	6.845	6	1	9
33	R:R:P226	7.6425	4	0	5
34	R:R:F241	7.686	5	1	9
35	R:R:F245	10.282	5	1	8
36	R:R:Y248	6.94	6	1	7
37	R:R:H249	10.1283	6	1	8
38	R:R:R252	6.77143	7	1	6
39	R:R:R255	8.4	5	0	5
40	R:R:I273	3.46	4	0	5
41	R:R:Y277	9.852	5	1	5
42	R:R:I278	5.16	4	0	4
43	R:R:R281	6.92571	7	1	6
44	R:R:F285	7.9025	4	1	7
45	R:R:N291	6.888	5	3	9
46	R:R:Y295	5.88833	6	3	9
47	R:R:F296	6.106	5	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R255	R:R:S258	26.4334	3.95	Yes	No	0	5	2
2	R:R:I273	R:R:S258	22.0983	4.64	Yes	No	0	5	2
3	R:R:I273	R:R:V272	14.2694	1.54	Yes	No	0	5	3
4	L:L:?1	R:R:R281	22.606	6.96	Yes	Yes	1	0	6
5	R:R:R281	R:R:Y277	11.079	18.52	Yes	Yes	1	6	5
6	R:R:R255	R:R:Y277	43.9279	6.17	Yes	Yes	0	5	5
7	R:R:P282	R:R:Y30	15.653	8.34	No	Yes	1	5	8
8	R:R:P282	R:R:Y25	14.3838	5.56	No	Yes	0	5	4
9	L:L:?1	R:R:W88	25.1642	8.97	Yes	Yes	1	0	8
10	R:R:W88	R:R:Y90	15.001	11.58	Yes	Yes	1	8	7
11	R:R:R81	R:R:Y90	10.1782	2.06	No	Yes	0	5	7
12	R:R:F72	R:R:L102	15.6231	9.74	Yes	Yes	0	7	7
13	R:R:F72	R:R:S288	31.1268	3.96	Yes	No	0	7	9
14	R:R:L73	R:R:S288	13.1296	7.51	No	No	0	6	9
15	R:R:G37	R:R:L73	11.2831	1.71	No	No	0	8	6
16	R:R:D69	R:R:S288	30.8879	5.89	Yes	No	0	9	9
17	R:R:D69	R:R:N41	26.0751	4.04	Yes	No	0	9	9
18	R:R:N41	R:R:P292	25.5176	8.15	No	No	0	9	9
19	R:R:P292	R:R:V44	20.3215	5.3	No	No	0	9	9
20	R:R:F296	R:R:V44	11.8953	7.87	Yes	No	0	6	9
21	R:R:S66	R:R:V44	13.4133	1.62	No	No	0	9	9
22	R:R:S66	R:R:V67	11.5618	1.62	No	No	0	9	7
23	R:R:F63	R:R:V67	10.8501	7.87	No	No	0	6	7
24	R:R:R281	R:R:Y248	36.4673	5.14	Yes	Yes	1	6	7
25	R:R:H249	R:R:Y248	64.5381	5.44	Yes	Yes	1	8	7
26	R:R:F245	R:R:H249	94.3609	5.66	Yes	Yes	1	8	8
27	R:R:F245	R:R:I110	89.0504	13.82	Yes	No	1	8	8
28	R:R:I110	R:R:P199	100	3.39	No	Yes	0	8	8
29	R:R:L111	R:R:P199	95.4708	3.28	No	Yes	0	6	8
30	R:R:I146	R:R:L111	94.6048	7.14	No	No	0	7	6
31	R:R:F115	R:R:I146	83.5606	7.54	Yes	No	0	6	7
32	R:R:F115	R:R:Y61	23.7358	7.22	Yes	Yes	6	6	7
33	R:R:D119	R:R:Y61	23.3874	6.9	No	Yes	0	8	7
34	R:R:D119	R:R:S58	20.2867	7.36	No	No	0	8	8
35	R:R:R129	R:R:S58	18.9478	5.27	Yes	No	0	5	8
36	R:R:F112	R:R:I146	22.9494	8.79	Yes	No	0	8	7
37	R:R:F112	R:R:N64	13.254	13.29	Yes	Yes	2	8	9
38	R:R:D69	R:R:L65	10.7257	5.43	Yes	Yes	3	9	9
39	R:R:D69	R:R:N291	14.8318	8.08	Yes	Yes	3	9	9
40	R:R:I157	R:R:Y100	12.9504	3.63	Yes	Yes	0	4	6
41	R:R:F175	R:R:R252	18.9429	5.34	Yes	Yes	1	4	6
42	R:R:R252	R:R:Y277	20.7147	10.29	Yes	Yes	1	6	5
43	R:R:F196	R:R:H249	21.5658	27.15	Yes	Yes	1	8	8
44	R:R:F196	R:R:F241	17.8379	5.36	Yes	Yes	1	8	9
45	R:R:F241	R:R:F245	12.4328	10.72	Yes	Yes	1	9	8
46	R:R:F115	R:R:I118	58.5756	3.77	Yes	No	0	6	6
47	R:R:F241	R:R:M203	28.7129	11.2	Yes	No	1	9	8
48	R:R:M203	R:R:Y207	24.2634	4.79	No	Yes	1	8	9
49	R:R:F206	R:R:I118	57.2516	6.28	No	No	0	8	6
50	R:R:F206	R:R:Y121	48.5318	10.32	No	Yes	0	8	8
51	R:R:K125	R:R:Y121	16.2204	10.75	No	Yes	0	7	8
52	R:R:I210	R:R:Y121	28.7179	4.84	No	Yes	0	8	8
53	R:R:Q134	R:R:R129	13.4481	8.18	Yes	Yes	4	7	5
54	R:R:K125	R:R:Y126	14.6775	5.97	No	Yes	0	7	6
55	R:R:E153	R:R:L191	10.5266	3.98	No	Yes	0	5	5
56	R:R:L191	R:R:R252	11.079	3.64	Yes	Yes	1	5	6
57	R:R:P156	R:R:Y187	11.308	15.3	No	No	0	8	5
58	R:R:R255	R:R:R259	16.2901	8.53	Yes	No	0	5	3
59	R:R:P181	R:R:R259	13.9458	5.76	No	No	0	1	3
60	R:R:F196	R:R:T246	15.8371	6.49	Yes	No	0	8	5
61	R:R:V234	R:R:Y207	14.354	8.83	No	Yes	0	8	9
62	R:R:I210	R:R:L214	20.8342	2.85	No	No	0	8	7
63	R:R:A211	R:R:V234	11.4971	1.7	No	No	0	5	8
64	R:R:F245	R:R:N287	20.3862	16.92	Yes	No	0	8	9
65	R:R:P247	R:R:T246	11.8455	3.5	No	No	0	9	5
66	R:R:R281	R:R:Y30	13.2291	4.12	Yes	Yes	1	6	8
67	R:R:F285	R:R:F72	19.774	11.79	Yes	Yes	0	7	7
68	R:R:F285	R:R:Y30	13.6323	7.22	Yes	Yes	1	7	8
69	R:R:F285	R:R:Y248	19.5451	6.19	Yes	Yes	1	7	7
70	R:R:H249	R:R:Y107	12.3333	9.8	Yes	Yes	1	8	7
71	R:R:H249	R:R:R252	39.1997	4.51	Yes	Yes	1	8	6
72	R:R:F63	R:R:N64	11.7758	6.04	No	Yes	0	6	9
73	R:R:N287	R:R:N291	17.1461	6.81	No	Yes	0	9	9
74	R:R:Y248	R:R:Y277	19.8039	8.94	Yes	Yes	1	7	5
75	R:R:F241	R:R:I110	11.8704	6.28	Yes	No	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y30	5.03	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L79	9.91	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y83	9.23	1	Yes	No	0	5	0	1
L:L:?1	R:R:W88	8.97	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N98	4.91	1	Yes	No	0	4	0	1
L:L:?1	R:R:R99	13.04	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L102	12.88	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:H103	11.04	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:D174	4.86	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R281	6.96	1	Yes	Yes	0	6	0	1
R:R:L26	R:R:Y30	8.21	1	Yes	Yes	6	8	2	1
R:R:L26	R:R:Y83	12.89	1	Yes	No	6	5	2	1
R:R:I278	R:R:L26	4.28	0	Yes	Yes	4	6	2	2
R:R:L26	R:R:P282	3.28	1	Yes	No	6	5	2	2
R:R:L76	R:R:Y30	5.86	0	No	Yes	8	8	2	1
R:R:L79	R:R:Y30	9.38	1	No	Yes	6	8	1	1
R:R:I80	R:R:Y30	3.63	0	No	Yes	6	8	2	1
R:R:R281	R:R:Y30	4.12	1	Yes	Yes	6	8	1	1
R:R:P282	R:R:Y30	8.34	1	No	Yes	5	8	2	1
R:R:F285	R:R:Y30	7.22	1	Yes	Yes	7	8	2	1
R:R:F72	R:R:L102	9.74	0	Yes	Yes	7	7	2	1
R:R:F285	R:R:F72	11.79	1	Yes	Yes	7	7	2	2
R:R:N98	R:R:T75	8.77	0	No	No	4	6	1	2
R:R:L102	R:R:T75	7.37	1	Yes	No	7	6	1	2
R:R:M78	R:R:W88	4.65	1	No	Yes	7	8	2	1
R:R:M78	R:R:Y90	10.78	1	No	Yes	7	7	2	2
R:R:M78	R:R:N98	9.82	1	No	No	7	4	2	1
R:R:L79	R:R:Y83	5.86	1	No	No	6	5	1	1
R:R:S82	R:R:W88	8.65	0	No	Yes	5	8	2	1
R:R:W88	R:R:Y90	11.58	1	Yes	Yes	8	7	1	2
R:R:C95	R:R:W88	6.53	0	No	Yes	9	8	2	1
R:R:C95	R:R:R99	4.18	0	No	Yes	9	6	2	1
R:R:I157	R:R:R99	3.76	1	Yes	Yes	4	6	2	1
R:R:H103	R:R:L102	3.86	1	Yes	Yes	5	7	1	1
R:R:H103	R:R:I157	3.98	1	Yes	Yes	5	4	1	2
R:R:F175	R:R:H103	5.66	1	Yes	Yes	4	5	2	1
R:R:F175	R:R:I157	7.54	1	Yes	Yes	4	4	2	2
R:R:D174	R:R:S177	10.31	1	Yes	No	5	4	1	2
R:R:D174	R:R:R281	3.57	1	Yes	Yes	5	6	1	1
R:R:Y248	R:R:Y277	8.94	1	Yes	Yes	7	5	2	2
R:R:R281	R:R:Y248	5.14	1	Yes	Yes	6	7	1	2
R:R:F285	R:R:Y248	6.19	1	Yes	Yes	7	7	2	2
R:R:R281	R:R:Y277	18.52	1	Yes	Yes	6	5	1	2
R:R:I278	R:R:R281	3.76	0	Yes	Yes	4	6	2	1
R:R:F285	R:R:R281	6.41	1	Yes	Yes	7	6	2	1
R:R:G91	R:R:W88	2.81	0	No	Yes	8	8	2	1
R:R:I96	R:R:R99	2.51	0	No	Yes	7	6	2	1
R:R:D174	R:R:S178	1.47	1	Yes	No	5	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YKV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	257
Number of Links	310
Number of Hubs	47
Number of Links mediated by Hubs	178
Number of Communities	6
Number of Nodes involved in Communities	53
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	53325
Length Of Smallest Path	3
Average Path Length	11.7696
Length of Longest Path	26
Minimum Path Strength	1.53
Average Path Strength	6.62151
Maximum Path Strength	18.475
Minimum Path Correlation	0.7
Average Path Correlation	0.920069
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	52.0997
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.5918
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • multicellular organismal process • response to stimulus • macrophage activation involved in immune response • immune response • cell activation • cell activation involved in immune response • myeloid cell activation involved in immune response • myeloid leukocyte activation • leukocyte activation • immune effector process • macrophage activation • immune system process • leukocyte activation involved in immune response • cellular process • regulation of defense response • regulation of biological process • regulation of response to external stimulus • defense response • biological regulation • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • response to metal ion • response to chemical • response to calcium ion • chemotaxis • positive regulation of locomotion • regulation of chemotaxis • positive regulation of chemotaxis • taxis • regulation of locomotion • locomotion • regulation of systemic arterial blood pressure by renin-angiotensin • renin secretion into blood stream • regulation of systemic arterial blood pressure by hormone • system process • regulation of systemic arterial blood pressure mediated by a chemical signal • establishment of protein localization • signaling • transport • cell communication • protein localization to extracellular region • localization • secretion by cell • circulatory system process • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure • signal release • renal system process involved in regulation of systemic arterial blood pressure • regulation of biological quality • intracellular protein localization • blood circulation • renal system process • secretion • regulation of blood pressure • establishment of protein localization to extracellular region • cell-cell signaling • export from cell • regulation of systemic arterial blood pressure by circulatory renin-angiotensin • protein secretion • establishment of localization • regulation of systemic arterial blood pressure • endocrine process • protein transport • macromolecule localization • regulation of cellular process • regulation of protein metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of primary metabolic process • regulation of angiotensin metabolic process • metabolic process • protein metabolic process • macromolecule metabolic process • regulation of metabolic process • cellular response to stimulus • G protein-coupled receptor signaling pathway • signal transduction • multicellular organismal-level homeostasis • homeostatic process • energy homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXA5
Sequence	>8YKV_nogp_Chain_R C K N W L A A E A A L E K Y Y L S I F Y G I E F V V G V L G N T I V V W N S S N I Y L F N L S V S D L A F L C T L P M L I R S Y A N G N W I Y G D V L C I S N R Y V L H A N L Y T S I L F L T F I S I D R Y L I I K Y P F R E H L L Q K K E F A I L I S L A I W V L V T L E L L P I L P L D F A S S G D P N Y N L I Y S M C L T L L G F L I P L F V M C F F Y Y K I A L F L K Q R N R Q V A T A L P L E K P L N L V I M A V V I F S V L F T P Y H V M R N V R I A S R L G C T Q V V I N S F Y I V T R P L A F L N S V I N P V F Y F L L G D H F R D M L M N Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6IBB	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	-	-	-	2.12	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	6RNK	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	NF-56-EJ40	-	-	1.94	2019-08-14	doi.org/10.1038/s41586-019-1663-8
	6Z10	A	Alicarboxylic acid	Succinate	Succinate	Rattus norvegicus	PubChem 154585554	-	-	2.27	2020-09-16	doi.org/10.1021/acs.jmedchem.0c01020
	8JPN	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ1	2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPN (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		2.9	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	chim(Gs-CtGq)/β1/γ1	3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8JPP (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		3.2	2024-05-22	doi.org/10.1038/s41422-024-00968-7
	8YKW	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ1	2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKW (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.75	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-	Gi1/β1/γ1	2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKX (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Maleic acid	-		2.69	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8WOG	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-	Gi1/β1/γ2	2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WOG (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Succinic acid	-		2.97	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-	Gi1/β1/γ2	3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8WP1 (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	Cis-Epoxysuccinic acid	-		3.15	2024-09-11	doi.org/10.1016/j.celrep.2024.114381
	8YKV	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-	Gi1/β1/γ2	2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7
	8YKV (No Gprot)	A	Alicarboxylic acid	Succinate	Succinate	Homo sapiens	PubChem 137553168	-		2.48	2024-05-29	doi.org/10.1038/s41422-024-00984-7

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.