psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M32	R:R:T29	4.52	No	No	0	6	4
2	R:R:E31	R:R:I35	4.1	No	No	0	6	7
3	R:R:I94	R:R:M32	5.83	Yes	No	0	7	6
4	R:R:F34	R:R:V38	5.24	No	No	0	4	5
5	R:R:T39	R:R:T90	7.85	No	No	0	7	8
6	R:R:T39	R:R:W440	6.06	No	No	0	7	9
7	R:R:N87	R:R:S43	8.94	No	No	0	9	8
8	R:R:G82	R:R:T46	5.46	No	No	1	9	8
9	R:R:M86	R:R:T46	7.53	Yes	No	1	9	8
10	R:R:T447	R:R:T46	9.42	Yes	No	0	8	8
11	R:R:G49	R:R:V48	3.68	No	No	0	9	5
12	R:R:G49	R:R:P450	4.06	No	No	0	9	9
13	R:R:A75	R:R:N50	4.69	No	No	0	9	9
14	R:R:D78	R:R:N50	6.73	No	No	0	9	9
15	R:R:N50	R:R:P450	9.77	No	No	0	9	9
16	R:R:L467	R:R:L52	4.15	No	Yes	0	7	8
17	R:R:L468	R:R:L52	4.15	No	Yes	0	8	8
18	R:R:V53	R:R:Y453	6.31	No	Yes	0	9	9
19	R:R:F72	R:R:M54	9.95	Yes	No	2	8	8
20	R:R:C76	R:R:M54	4.86	No	No	2	8	8
21	R:R:L79	R:R:M54	4.24	No	No	0	9	8
22	R:R:L467	R:R:L55	4.15	No	No	0	7	6
23	R:R:F460	R:R:S56	5.28	Yes	No	0	9	9
24	R:R:S56	R:R:T463	4.8	No	No	0	9	9
25	R:R:I57	R:R:N68	5.66	No	Yes	2	9	9
26	R:R:F72	R:R:I57	5.02	Yes	No	2	8	9
27	R:R:F460	R:R:I57	5.02	Yes	No	2	9	9
28	R:R:F72	R:R:K58	12.41	Yes	No	0	8	5
29	R:R:N60	R:R:Q62	3.96	Yes	No	6	8	6
30	R:R:L63	R:R:N60	9.61	No	Yes	0	9	8
31	R:R:E459	R:R:N60	5.26	No	Yes	6	8	8
32	R:R:N60	R:R:T463	7.31	Yes	No	0	8	9
33	R:R:Q64	R:R:R61	4.67	No	No	0	8	8
34	R:R:E459	R:R:Q62	6.37	No	No	6	8	6
35	R:R:F460	R:R:L63	13.4	Yes	No	0	9	9
36	R:R:N68	R:R:T65	5.85	Yes	No	0	9	8
37	R:R:R394	R:R:T65	6.47	No	No	0	7	8
38	R:R:R144	R:R:V66	7.85	Yes	No	0	9	8
39	R:R:L71	R:R:N67	8.24	No	No	0	8	9
40	R:R:N67	R:R:V398	8.87	No	No	0	9	9
41	R:R:I402	R:R:N67	5.66	Yes	No	0	9	9
42	R:R:L71	R:R:N68	5.49	No	Yes	0	8	9
43	R:R:F460	R:R:N68	4.83	Yes	Yes	2	9	9
44	R:R:T146	R:R:Y69	9.99	No	No	0	6	7
45	R:R:F70	R:R:N122	6.04	Yes	Yes	5	8	9
46	R:R:F70	R:R:I125	6.28	Yes	No	0	8	8
47	R:R:F70	R:R:I126	5.02	Yes	No	0	8	9
48	R:R:F70	R:R:I153	13.82	Yes	No	5	8	9
49	R:R:L71	R:R:Y453	10.55	No	Yes	0	8	9
50	R:R:C76	R:R:F72	5.59	No	Yes	2	8	8
51	R:R:N122	R:R:S73	7.45	Yes	No	5	9	9
52	R:R:I153	R:R:S73	4.64	No	No	5	9	9
53	R:R:S73	R:R:W157	4.94	No	Yes	0	9	9
54	R:R:D78	R:R:S446	11.78	No	No	0	9	9
55	R:R:D78	R:R:R449	11.91	No	Yes	0	9	9
56	R:R:I80	R:R:L111	4.28	No	No	0	8	6
57	R:R:I80	R:R:V115	7.68	No	No	0	8	8
58	R:R:I81	R:R:S85	4.64	No	Yes	0	9	9
59	R:R:I81	R:R:S446	7.74	No	No	0	9	9
60	R:R:G82	R:R:M86	6.99	No	Yes	1	9	9
61	R:R:S85	R:R:W108	3.71	Yes	Yes	1	9	7
62	R:R:D112	R:R:S85	10.31	No	Yes	1	9	9
63	R:R:S85	R:R:Y443	6.36	Yes	Yes	1	9	9
64	R:R:M86	R:R:Y443	4.79	Yes	Yes	1	9	9
65	R:R:L88	R:R:W108	13.67	No	Yes	0	7	7
66	R:R:T93	R:R:Y89	6.24	No	Yes	0	7	8
67	R:R:W108	R:R:Y89	3.86	Yes	Yes	1	7	8
68	R:R:Y439	R:R:Y89	8.94	No	Yes	0	7	8
69	R:R:W440	R:R:Y89	15.43	No	Yes	1	9	8
70	R:R:Y443	R:R:Y89	6.95	Yes	Yes	1	9	8
71	R:R:W98	R:R:Y92	4.82	Yes	No	0	9	8
72	R:R:K95	R:R:Y97	9.55	No	No	1	5	5
73	R:R:K95	R:R:P99	10.04	No	Yes	1	5	5
74	R:R:P99	R:R:Y97	6.95	Yes	No	1	5	5
75	R:R:P99	R:R:W98	5.4	Yes	Yes	1	5	9
76	R:R:L100	R:R:W98	4.56	No	Yes	1	7	9
77	R:R:V104	R:R:W98	3.68	No	Yes	1	6	9
78	R:R:C105	R:R:W98	6.53	No	Yes	1	9	9
79	R:R:W108	R:R:W98	7.5	Yes	Yes	1	7	9
80	R:R:C185	R:R:W98	14.37	Yes	Yes	1	9	9
81	R:R:L100	R:R:P99	4.93	No	Yes	1	7	5
82	R:R:L100	R:R:V104	5.96	No	No	1	7	6
83	R:R:A102	R:R:R178	6.91	No	Yes	0	4	5
84	R:R:C105	R:R:C185	7.28	No	Yes	1	9	9
85	R:R:D106	R:R:Q172	7.83	No	No	7	8	7
86	R:R:D106	R:R:R178	10.72	No	Yes	7	8	5
87	R:R:D112	R:R:W108	5.58	No	Yes	1	9	7
88	R:R:C185	R:R:W108	3.92	Yes	Yes	1	9	7
89	R:R:W108	R:R:Y443	3.86	Yes	Yes	1	7	9
90	R:R:C185	R:R:L109	4.76	Yes	No	0	9	8
91	R:R:D112	R:R:Y443	8.05	No	Yes	1	9	9
92	R:R:W164	R:R:Y113	8.68	Yes	Yes	4	8	9
93	R:R:I168	R:R:Y113	8.46	No	Yes	0	8	9
94	R:R:F189	R:R:Y113	6.19	Yes	Yes	4	8	9
95	R:R:L190	R:R:Y113	4.69	No	Yes	4	5	9
96	R:R:S160	R:R:V114	4.85	No	No	0	9	8
97	R:R:V115	R:R:W157	4.9	No	Yes	0	8	9
98	R:R:S116	R:R:W413	3.71	No	Yes	0	8	9
99	R:R:N117	R:R:W164	18.08	No	Yes	0	9	8
100	R:R:A203	R:R:N117	4.69	No	No	0	9	9
101	R:R:A118	R:R:W157	10.37	No	Yes	0	9	9
102	R:R:R449	R:R:S119	3.95	Yes	No	0	9	9
103	R:R:L159	R:R:M121	7.07	No	No	0	6	8
104	R:R:I153	R:R:N122	4.25	No	Yes	5	9	9
105	R:R:A156	R:R:N122	4.69	No	Yes	0	9	9
106	R:R:L123	R:R:M211	5.65	No	No	0	9	9
107	R:R:I125	R:R:M152	7.29	No	No	0	8	8
108	R:R:I126	R:R:I402	11.77	No	Yes	0	9	9
109	R:R:M211	R:R:S127	7.67	No	No	0	9	9
110	R:R:F128	R:R:F132	5.36	No	Yes	0	7	7
111	R:R:F128	R:R:L214	13.4	No	No	0	7	8
112	R:R:D129	R:R:Y140	8.05	No	Yes	3	9	9
113	R:R:D129	R:R:R144	9.53	No	Yes	3	9	9
114	R:R:C133	R:R:R130	6.96	No	Yes	3	9	9
115	R:R:R130	R:R:R144	4.26	Yes	Yes	3	9	9
116	R:R:E395	R:R:R130	8.14	No	Yes	0	9	9
117	R:R:R130	R:R:V398	9.15	Yes	No	0	9	9
118	R:R:R130	R:R:T399	12.94	Yes	No	0	9	9
119	R:R:I402	R:R:R130	6.26	Yes	Yes	0	9	9
120	R:R:F132	R:R:Y131	7.22	Yes	Yes	0	7	9
121	R:R:T135	R:R:Y131	14.98	No	Yes	0	9	9
122	R:R:L214	R:R:Y131	7.03	No	Yes	0	8	9
123	R:R:F132	R:R:K136	6.2	Yes	No	0	7	7
124	R:R:F132	R:R:Y140	10.32	Yes	Yes	0	7	9
125	R:R:C133	R:R:Y140	5.38	No	Yes	3	9	9
126	R:R:C133	R:R:R144	5.57	No	Yes	3	9	9
127	R:R:R143	R:R:T139	3.88	No	No	0	6	7
128	R:R:P141	R:R:Y140	4.17	No	Yes	0	7	9
129	R:R:R144	R:R:Y140	7.2	Yes	Yes	3	9	9
130	R:R:M148	R:R:T145	4.52	No	No	0	8	9
131	R:R:K147	R:R:T146	4.5	No	No	0	6	6
132	R:R:L159	R:R:L163	4.15	No	No	0	6	8
133	R:R:A165	R:R:F161	5.55	No	No	0	7	7
134	R:R:F189	R:R:W164	6.01	Yes	Yes	4	8	8
135	R:R:T199	R:R:W164	4.85	No	Yes	4	9	8
136	R:R:F170	R:R:F173	4.29	No	No	0	7	6
137	R:R:Q188	R:R:W171	6.57	Yes	No	0	8	7
138	R:R:F189	R:R:W171	6.01	Yes	No	0	8	7
139	R:R:Q172	R:R:R178	9.35	No	Yes	7	7	5
140	R:R:Q172	R:R:Q188	5.12	No	Yes	0	7	8
141	R:R:Q188	R:R:V175	4.3	Yes	No	0	8	5
142	R:R:R178	R:R:V180	6.54	Yes	No	0	5	5
143	R:R:Q188	R:R:T179	9.92	Yes	No	0	8	5
144	R:R:F186	R:R:V180	11.8	No	No	0	4	5
145	R:R:Q188	R:R:V180	4.3	Yes	No	0	8	5
146	R:R:N183	R:R:P181	4.89	No	No	9	4	3
147	R:R:P181	R:R:Q184	6.32	No	Yes	9	3	5
148	R:R:N183	R:R:Q184	5.28	No	Yes	9	4	5
149	R:R:F186	R:R:Q184	8.2	No	Yes	0	4	5
150	R:R:A187	R:R:F189	5.55	No	Yes	0	7	8
151	R:R:F189	R:R:L190	7.31	Yes	No	4	8	5
152	R:R:F189	R:R:V195	5.24	Yes	No	0	8	8
153	R:R:F189	R:R:T199	3.89	Yes	No	4	8	9
154	R:R:L190	R:R:T196	5.9	No	No	0	5	8
155	R:R:N192	R:R:P193	4.89	No	No	0	7	5
156	R:R:N192	R:R:V195	8.87	No	No	0	7	8
157	R:R:F197	R:R:I201	5.02	No	No	0	7	7
158	R:R:F197	R:R:L421	7.31	No	No	0	7	7
159	R:R:F204	R:R:Y205	12.38	Yes	Yes	10	9	8
160	R:R:F204	R:R:V208	3.93	Yes	No	0	9	8
161	R:R:F204	R:R:F409	5.36	Yes	No	0	9	9
162	R:R:F204	R:R:T414	3.89	Yes	No	0	9	7
163	R:R:F204	R:R:N417	27.79	Yes	No	10	9	9
164	R:R:N417	R:R:Y205	5.81	No	Yes	10	9	8
165	R:R:I410	R:R:V208	4.61	No	No	0	8	8
166	R:R:L406	R:R:M211	9.9	No	No	0	8	9
167	R:R:I218	R:R:Y215	10.88	No	Yes	0	9	9
168	R:R:T399	R:R:Y215	3.75	No	Yes	0	9	9
169	R:R:I402	R:R:Y215	4.84	Yes	Yes	0	9	9
170	R:R:F403	R:R:Y215	12.38	No	Yes	0	8	9
171	R:R:R223	R:R:Y219	8.23	No	No	0	7	8
172	R:R:R225	R:R:S222	5.27	No	No	0	8	9
173	R:R:H227	R:R:R396	13.54	No	No	0	7	7
174	R:R:M391	R:R:Q390	5.44	No	No	0	6	4
175	R:R:Q390	R:R:R394	4.67	No	No	0	4	7
176	R:R:K397	R:R:N457	5.6	No	No	0	9	9
177	R:R:C456	R:R:R400	4.18	No	No	0	8	7
178	R:R:C456	R:R:T401	6.76	No	No	0	8	9
179	R:R:I405	R:R:R449	3.76	No	Yes	0	9	9
180	R:R:I405	R:R:Y453	6.04	No	Yes	0	9	9
181	R:R:I410	R:R:L406	4.28	No	No	0	8	8
182	R:R:F409	R:R:W413	9.02	No	Yes	0	9	9
183	R:R:T412	R:R:W413	4.85	No	Yes	8	9	9
184	R:R:N445	R:R:T412	13.16	No	No	8	9	9
185	R:R:C442	R:R:W413	18.28	No	Yes	0	9	9
186	R:R:N445	R:R:W413	6.78	No	Yes	8	9	9
187	R:R:P415	R:R:T414	5.25	No	No	0	9	7
188	R:R:V420	R:R:Y416	6.31	No	No	0	8	9
189	R:R:Y416	R:R:Y439	3.97	No	No	0	9	7
190	R:R:C442	R:R:Y416	4.03	No	No	0	9	9
191	R:R:M419	R:R:W435	9.31	No	Yes	0	7	6
192	R:R:F425	R:R:V422	3.93	No	No	0	6	7
193	R:R:I430	R:R:V422	4.61	No	No	0	6	7
194	R:R:N423	R:R:Q427	9.24	No	No	0	5	3
195	R:R:C426	R:R:F425	4.19	No	No	0	7	6
196	R:R:C426	R:R:C429	7.28	No	No	0	7	7
197	R:R:I430	R:R:W435	11.74	No	Yes	0	6	6
198	R:R:P431	R:R:V434	8.84	No	No	0	6	5
199	R:R:W435	R:R:Y439	8.68	Yes	No	0	6	7
200	R:R:W440	R:R:Y443	4.82	No	Yes	1	9	9
201	R:R:N445	R:R:R449	10.85	No	Yes	0	9	9
202	R:R:F460	R:R:Y453	5.16	Yes	Yes	0	9	9
203	R:R:F460	R:R:N457	8.46	Yes	No	0	9	9
204	R:R:K461	R:R:K462	5.75	No	No	0	9	6
205	R:R:F464	R:R:L52	3.65	No	Yes	0	9	8
206	R:R:F128	R:R:L124	3.65	No	No	0	7	8
207	R:R:L74	R:R:R449	3.64	No	Yes	0	9	9
208	R:R:P99	R:R:V91	3.53	Yes	No	0	5	8
209	R:R:P207	R:R:V120	3.53	No	No	0	9	9
210	R:R:G438	R:R:M419	3.49	No	No	0	7	7
211	R:R:A118	R:R:S160	3.42	No	No	0	9	9
212	R:R:N423	R:R:W435	3.39	No	Yes	0	5	6
213	R:R:I430	R:R:P431	3.39	No	No	0	6	6
214	R:R:Q184	R:R:Y92	3.38	Yes	No	0	5	8
215	R:R:L206	R:R:P207	3.28	No	No	0	8	9
216	R:R:L441	R:R:P415	3.28	No	No	0	9	9
217	R:R:C452	R:R:I405	3.27	No	No	0	9	9
218	R:R:A110	R:R:I168	3.25	No	No	0	8	8
219	R:R:A408	R:R:I448	3.25	No	No	0	8	7
220	R:R:A454	R:R:K461	3.21	No	No	0	9	9
221	R:R:A110	R:R:L169	3.15	No	No	0	8	6
222	R:R:M86	R:R:S43	3.07	Yes	No	0	9	8
223	R:R:I448	R:R:T447	3.04	No	Yes	0	7	8
224	R:R:L44	R:R:V48	2.98	No	No	0	5	5
225	R:R:L52	R:R:V48	2.98	Yes	No	0	8	5
226	R:R:L42	R:R:T447	2.95	No	Yes	0	6	8
227	R:R:I35	R:R:I94	2.94	No	Yes	0	7	7
228	R:R:M148	R:R:M152	2.89	No	No	0	8	8
229	R:R:I51	R:R:L79	2.85	No	No	0	7	9
230	R:R:I210	R:R:L124	2.85	No	No	0	8	8
231	R:R:I210	R:R:L206	2.85	No	No	0	8	8
232	R:R:I210	R:R:L214	2.85	No	No	0	8	8
233	R:R:I216	R:R:L220	2.85	No	No	0	4	4
234	R:R:L151	R:R:M148	2.83	No	No	0	3	8
235	R:R:G101	R:R:W98	2.81	No	Yes	0	8	9
236	R:R:A149	R:R:F70	2.77	No	Yes	0	8	8
237	R:R:A83	R:R:F84	2.77	No	No	0	5	6
238	R:R:H217	R:R:V213	2.77	No	No	0	7	5
239	R:R:L407	R:R:L411	2.77	No	No	0	8	5
240	R:R:A454	R:R:F464	2.77	No	No	0	9	9
241	R:R:A149	R:R:Y69	2.67	No	No	0	8	7
242	R:R:A200	R:R:Y205	2.67	No	Yes	0	8	8
243	R:R:F161	R:R:V114	2.62	No	No	0	7	8
244	R:R:A77	R:R:W157	2.59	No	Yes	0	9	9
245	R:R:F197	R:R:T424	2.59	No	No	0	7	7
246	R:R:S436	R:R:Y89	2.54	No	Yes	0	6	8
247	R:R:F84	R:R:L111	2.44	No	No	0	6	6
248	R:R:F403	R:R:L407	2.44	No	No	0	8	8
249	R:R:L468	R:R:R465	2.43	No	No	0	8	6
250	R:R:L421	R:R:Y205	2.34	No	Yes	0	7	8
251	R:R:H217	R:R:Y131	2.18	No	Yes	0	7	9
252	R:R:A165	R:R:P166	1.87	No	No	0	7	9
253	R:R:G40	R:R:S43	1.86	No	No	0	6	8
254	R:R:G82	R:R:V47	1.84	No	No	0	9	7
255	R:R:A404	R:R:C452	1.81	No	No	0	9	9
256	R:R:A404	R:R:C456	1.81	No	No	0	9	8
257	R:R:A221	R:R:V134	1.7	No	No	0	8	9
258	R:R:A36	R:R:I94	1.62	No	Yes	0	6	7
259	R:R:S222	R:R:V134	1.62	No	No	0	9	9
260	R:R:A156	R:R:M121	1.61	No	No	0	9	8
261	R:R:A458	R:R:K397	1.61	No	No	0	5	9
262	R:R:V158	R:R:V162	1.6	No	No	0	5	5
263	R:R:T212	R:R:V208	1.59	No	No	0	7	8
264	R:R:T447	R:R:V444	1.59	Yes	No	0	8	6
265	R:R:A194	R:R:N192	1.56	No	No	0	5	7
266	R:R:I218	R:R:S222	1.55	No	No	0	9	9
267	R:R:I35	R:R:T39	1.52	No	No	0	7	7
268	R:R:I94	R:R:T90	1.52	Yes	No	0	7	8
269	R:R:I94	R:R:T93	1.52	Yes	No	0	7	7
270	R:R:I216	R:R:T212	1.52	No	No	0	4	7
271	R:R:K136	R:R:T139	1.5	No	No	0	7	7
272	R:R:L107	R:R:V103	1.49	No	No	0	7	5
273	R:R:L421	R:R:V418	1.49	No	No	0	7	7
274	R:R:F170	R:R:P166	1.44	No	No	0	7	9
275	R:R:I437	R:R:L441	1.43	No	No	0	5	9
276	R:R:H466	R:R:T463	1.37	No	No	0	6	9
277	R:R:F161	R:R:V162	1.31	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L52	3.7325	4	0	8
2	R:R:N60	6.535	4	6	8
3	R:R:N68	5.4575	4	2	9
4	R:R:F70	6.786	5	5	8
5	R:R:F72	8.2425	4	2	8
6	R:R:S85	6.255	4	1	9
7	R:R:M86	5.595	4	1	9
8	R:R:Y89	7.32667	6	1	8
9	R:R:I94	2.686	5	0	7
10	R:R:W98	6.20875	8	1	9
11	R:R:P99	6.17	5	1	5
12	R:R:W108	6.01429	7	1	7
13	R:R:Y113	7.005	4	4	9
14	R:R:N122	5.6075	4	5	9
15	R:R:R130	7.95167	6	3	9
16	R:R:Y131	7.8525	4	0	9
17	R:R:F132	7.275	4	0	7
18	R:R:Y140	7.024	5	3	9
19	R:R:R144	6.882	5	3	9
20	R:R:W157	5.7	4	0	9
21	R:R:W164	9.405	4	4	8
22	R:R:R178	8.38	4	7	5
23	R:R:Q184	5.795	4	9	5
24	R:R:C185	7.5825	4	1	9
25	R:R:Q188	6.042	5	0	8
26	R:R:F189	5.74286	7	4	8
27	R:R:F204	10.67	5	10	9
28	R:R:Y205	5.8	4	10	8
29	R:R:Y215	7.9625	4	0	9
30	R:R:I402	7.1325	4	0	9
31	R:R:W413	8.528	5	8	9
32	R:R:W435	8.28	4	0	6
33	R:R:Y443	5.805	6	1	9
34	R:R:T447	4.25	4	0	8
35	R:R:R449	6.822	5	0	9
36	R:R:Y453	7.015	4	0	9
37	R:R:F460	7.025	6	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T93	R:R:Y89	11.8944	6.24	No	Yes	0	7	8
2	R:R:M86	R:R:Y443	11.8091	4.79	Yes	Yes	1	9	9
3	R:R:G49	R:R:P450	12.6625	4.06	No	No	0	9	9
4	R:R:N50	R:R:P450	13.7009	9.77	No	No	0	9	9
5	R:R:D78	R:R:N50	15.7606	6.73	No	No	0	9	9
6	R:R:D78	R:R:S446	56.0553	11.78	No	No	0	9	9
7	R:R:I81	R:R:S446	55.6001	7.74	No	No	0	9	9
8	R:R:I81	R:R:S85	55.1506	4.64	No	Yes	0	9	9
9	R:R:S85	R:R:W108	36.2522	3.71	Yes	Yes	1	9	7
10	R:R:W108	R:R:Y89	12.708	3.86	Yes	Yes	1	7	8
11	R:R:S85	R:R:Y443	17.8629	6.36	Yes	Yes	1	9	9
12	R:R:G49	R:R:V48	11.6184	3.68	No	No	0	9	5
13	R:R:F460	R:R:Y453	15.863	5.16	Yes	Yes	0	9	9
14	R:R:I405	R:R:Y453	94.1936	6.04	No	Yes	0	9	9
15	R:R:I405	R:R:R449	93.1183	3.76	No	Yes	0	9	9
16	R:R:D78	R:R:R449	63.3496	11.91	No	Yes	0	9	9
17	R:R:Y439	R:R:Y89	14.7791	8.94	No	Yes	0	7	8
18	R:R:Y416	R:R:Y439	20.6765	3.97	No	No	0	9	7
19	R:R:C442	R:R:Y416	21.6722	4.03	No	No	0	9	9
20	R:R:C442	R:R:W413	22.1701	18.28	No	Yes	0	9	9
21	R:R:N445	R:R:W413	32.5994	6.78	No	Yes	8	9	9
22	R:R:N445	R:R:R449	33.8283	10.85	No	Yes	0	9	9
23	R:R:L71	R:R:Y453	90.2421	10.55	No	Yes	0	8	9
24	R:R:L71	R:R:N68	14.1532	5.49	No	Yes	0	8	9
25	R:R:L71	R:R:N67	100	8.24	No	No	0	8	9
26	R:R:N67	R:R:V398	33.0232	8.87	No	No	0	9	9
27	R:R:R130	R:R:V398	32.7388	9.15	Yes	No	0	9	9
28	R:R:R130	R:R:R144	38.0416	4.26	Yes	Yes	3	9	9
29	R:R:I402	R:R:N67	67.321	5.66	Yes	No	0	9	9
30	R:R:I402	R:R:R130	42.8523	6.26	Yes	Yes	0	9	9
31	R:R:I126	R:R:I402	39.8509	11.77	No	Yes	0	9	9
32	R:R:F70	R:R:I126	39.3502	5.02	Yes	No	0	8	9
33	R:R:F70	R:R:N122	18.1218	6.04	Yes	Yes	5	8	9
34	R:R:F70	R:R:I153	14.9697	13.82	Yes	No	5	8	9
35	R:R:N122	R:R:S73	14.4377	7.45	Yes	No	5	9	9
36	R:R:I153	R:R:S73	14.2329	4.64	No	No	5	9	9
37	R:R:S73	R:R:W157	27.1287	4.94	No	Yes	0	9	9
38	R:R:W108	R:R:W98	36.1782	7.5	Yes	Yes	1	7	9
39	R:R:W98	R:R:Y92	28.9579	4.82	Yes	No	0	9	8
40	R:R:F186	R:R:V180	24.5768	11.8	No	No	0	4	5
41	R:R:F186	R:R:Q184	25.4644	8.2	No	Yes	0	4	5
42	R:R:Q184	R:R:Y92	28.0931	3.38	Yes	No	0	5	8
43	R:R:F189	R:R:W171	15.6382	6.01	Yes	No	0	8	7
44	R:R:Q188	R:R:W171	16.5856	6.57	Yes	No	0	8	7
45	R:R:Q188	R:R:V180	19.9226	4.3	Yes	No	0	8	5
46	R:R:A118	R:R:W157	16.156	10.37	No	Yes	0	9	9
47	R:R:A118	R:R:S160	14.5657	3.42	No	No	0	9	9
48	R:R:S160	R:R:V114	12.9698	4.85	No	No	0	9	8
49	R:R:F204	R:R:F409	21.1516	5.36	Yes	No	0	9	9
50	R:R:F409	R:R:W413	22.0563	9.02	No	Yes	0	9	9
51	R:R:F128	R:R:F132	29.3733	5.36	No	Yes	0	7	7
52	R:R:F132	R:R:Y140	63.7677	10.32	Yes	Yes	0	7	9
53	R:R:C133	R:R:Y140	34.3945	5.38	No	Yes	3	9	9
54	R:R:C133	R:R:R130	35.6377	6.96	No	Yes	3	9	9
55	R:R:R144	R:R:Y140	34.4656	7.2	Yes	Yes	3	9	9
56	R:R:F128	R:R:L214	13.3794	13.4	No	No	0	7	8
57	R:R:L214	R:R:Y131	13.4306	7.03	No	Yes	0	8	9
58	R:R:F132	R:R:Y131	24.0363	7.22	Yes	Yes	0	7	9
59	R:R:F161	R:R:V114	11.3681	2.62	No	No	0	7	8
60	R:R:W435	R:R:Y439	12.819	8.68	Yes	No	0	6	7
61	R:R:F128	R:R:L124	13.3794	3.65	No	No	0	7	8
62	R:R:I210	R:R:L214	21.4276	2.85	No	No	0	8	8
63	R:R:I210	R:R:L206	24.0904	2.85	No	No	0	8	8
64	R:R:L206	R:R:P207	16.065	3.28	No	No	0	8	9
65	R:R:I210	R:R:L124	10.7081	2.85	No	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6KP6

PDB Summary
PDB	6KP6
Class	A
SubFamily	Amine
Type	Acetylcholine (muscarinic)
SubType	M4
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3
Date	2020-03-11
D.O.I.	doi.org/10.1107/S2052252520000597

Net Summary
I_min	3.68
Number of Linked Nodes	247
Number of Links	277
Number of Hubs	37
Number of Links mediated by Hubs	152
Number of Communities	10
Number of Nodes involved in Communities	52
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	57442
Length Of Smallest Path	3
Average Path Length	15.9824
Length of Longest Path	36
Minimum Path Strength	1.455
Average Path Strength	6.76919
Maximum Path Strength	16.575
Minimum Path Correlation	0.7
Average Path Correlation	0.919062
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	39.5192
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7216
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • UDP-glycosyltransferase activity • alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity • glycosyltransferase activity • alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity • transferase activity • glucosyltransferase activity • hexosyltransferase activity • catalytic activity • UDP-glucosyltransferase activity • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Type B glycosyltransferase-like
SCOP2	Family Identifier	• G protein-coupled receptor-like • Type B glycosyltransferase-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>6KP6_Chain_R T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y T I K G Y W P L G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A A L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F A Q F L S N P A V T F G T A I A A F Y L P V V I M T V L Y I H I Y L A S R S R V H Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I R P A C Y A L C N A E F K K T F R H L L L C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275	Gi1/β1/γ2	3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275		3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	doi.org/10.1038/nature17188
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	9M4Q	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	doi.org/10.1038/nature25758
	9IQS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	Muscarinic toxin 3	-	3.6	2025-07-23	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6KP6.zip

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