psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E31	R:R:T29	4.23	No	No	0	6	4
2	R:R:E31	R:R:V30	5.7	No	No	0	6	4
3	R:R:K95	R:R:M32	5.76	No	No	0	5	6
4	R:R:F34	R:R:V38	3.93	No	No	0	4	5
5	R:R:G40	R:R:S43	3.71	No	No	0	6	8
6	R:R:N50	R:R:T46	4.39	Yes	No	0	9	8
7	R:R:T447	R:R:T46	12.56	No	No	0	8	8
8	R:R:G49	R:R:L52	5.13	No	No	0	9	8
9	R:R:D78	R:R:N50	5.39	Yes	Yes	0	9	9
10	R:R:L79	R:R:N50	4.12	No	Yes	0	9	9
11	R:R:N50	R:R:P450	6.52	Yes	No	0	9	9
12	R:R:I51	R:R:L79	7.14	No	No	0	7	9
13	R:R:P450	R:R:V53	5.3	No	No	0	9	9
14	R:R:F72	R:R:M54	7.46	No	Yes	0	8	8
15	R:R:L79	R:R:M54	4.24	No	Yes	0	9	8
16	R:R:L55	R:R:V59	7.45	No	No	0	6	7
17	R:R:I57	R:R:N68	12.74	Yes	Yes	0	9	9
18	R:R:I57	R:R:Y69	3.63	Yes	No	0	9	7
19	R:R:F72	R:R:I57	6.28	No	Yes	0	8	9
20	R:R:K58	R:R:Q64	4.07	No	No	0	5	8
21	R:R:L63	R:R:N60	13.73	Yes	No	0	9	8
22	R:R:N60	R:R:T463	4.39	No	No	0	8	9
23	R:R:L63	R:R:N68	5.49	Yes	Yes	2	9	9
24	R:R:F460	R:R:L63	6.09	Yes	Yes	2	9	9
25	R:R:R144	R:R:V66	15.69	Yes	No	0	9	8
26	R:R:D129	R:R:N67	5.39	Yes	No	3	9	9
27	R:R:N67	R:R:R144	8.44	No	Yes	3	9	9
28	R:R:L71	R:R:N68	4.12	No	Yes	2	8	9
29	R:R:F460	R:R:N68	4.83	Yes	Yes	2	9	9
30	R:R:D129	R:R:F70	4.78	Yes	Yes	0	9	8
31	R:R:A149	R:R:F70	4.16	No	Yes	0	8	8
32	R:R:L71	R:R:Y453	3.52	No	Yes	2	8	9
33	R:R:F460	R:R:L71	3.65	Yes	No	2	9	8
34	R:R:N122	R:R:S73	8.94	No	No	1	9	9
35	R:R:I153	R:R:S73	6.19	No	No	1	9	9
36	R:R:D78	R:R:L74	9.5	Yes	Yes	1	9	9
37	R:R:L74	R:R:N122	5.49	Yes	No	1	9	9
38	R:R:L123	R:R:L74	4.15	No	Yes	0	9	9
39	R:R:L74	R:R:N449	9.61	Yes	No	1	9	9
40	R:R:D78	R:R:S446	5.89	Yes	No	0	9	9
41	R:R:D78	R:R:N449	8.08	Yes	No	1	9	9
42	R:R:I81	R:R:S85	4.64	No	No	0	9	9
43	R:R:I81	R:R:V115	7.68	No	No	0	9	8
44	R:R:I81	R:R:S446	9.29	No	No	0	9	9
45	R:R:G82	R:R:M86	3.49	No	No	0	9	9
46	R:R:D112	R:R:S85	8.83	Yes	No	1	9	9
47	R:R:S85	R:R:Y443	11.45	No	Yes	1	9	9
48	R:R:M86	R:R:Y443	8.38	No	Yes	0	9	9
49	R:R:L88	R:R:W98	3.42	No	Yes	1	7	9
50	R:R:L88	R:R:W108	7.97	No	Yes	1	7	7
51	R:R:Y89	R:R:Y92	7.94	Yes	Yes	1	8	8
52	R:R:I93	R:R:Y89	6.04	No	Yes	1	7	8
53	R:R:W108	R:R:Y89	7.72	Yes	Yes	1	7	8
54	R:R:S436	R:R:Y89	3.82	No	Yes	0	6	8
55	R:R:Y439	R:R:Y89	14.89	Yes	Yes	1	7	8
56	R:R:P99	R:R:V91	3.53	No	No	0	5	8
57	R:R:I93	R:R:Y92	6.04	No	Yes	1	7	8
58	R:R:W98	R:R:Y92	10.61	Yes	Yes	1	9	8
59	R:R:D432	R:R:Y92	8.05	No	Yes	0	3	8
60	R:R:I94	R:R:P99	5.08	No	No	0	7	5
61	R:R:P99	R:R:W98	5.4	No	Yes	0	5	9
62	R:R:L100	R:R:W98	11.39	No	Yes	0	7	9
63	R:R:C105	R:R:W98	3.92	No	Yes	1	9	9
64	R:R:W108	R:R:W98	4.69	Yes	Yes	1	7	9
65	R:R:C185	R:R:W98	7.84	No	Yes	1	9	9
66	R:R:L100	R:R:V104	4.47	No	No	0	7	6
67	R:R:A102	R:R:R178	4.15	No	No	0	4	5
68	R:R:A102	R:R:D182	6.18	No	No	0	4	3
69	R:R:C105	R:R:C185	7.28	No	No	1	9	9
70	R:R:D106	R:R:R178	8.34	No	No	0	8	5
71	R:R:D112	R:R:W108	11.17	Yes	Yes	1	9	7
72	R:R:W108	R:R:Y439	5.79	Yes	Yes	1	7	7
73	R:R:I168	R:R:L109	5.71	No	No	0	8	8
74	R:R:I187	R:R:L109	5.71	Yes	No	0	7	8
75	R:R:D112	R:R:Y439	5.75	Yes	Yes	1	9	7
76	R:R:D112	R:R:Y443	12.64	Yes	Yes	1	9	9
77	R:R:W164	R:R:Y113	11.58	Yes	Yes	0	8	9
78	R:R:I187	R:R:Y113	6.04	Yes	Yes	0	7	9
79	R:R:Y113	R:R:Y416	10.92	Yes	Yes	1	9	9
80	R:R:Y113	R:R:Y439	6.95	Yes	Yes	1	9	7
81	R:R:F161	R:R:V114	3.93	No	No	0	7	8
82	R:R:S116	R:R:W413	4.94	No	Yes	0	8	9
83	R:R:M121	R:R:N117	8.41	No	No	0	8	9
84	R:R:N117	R:R:S160	4.47	No	No	0	9	9
85	R:R:N117	R:R:W164	10.17	No	Yes	0	9	8
86	R:R:A118	R:R:W157	7.78	No	No	0	9	9
87	R:R:P207	R:R:V120	3.53	Yes	No	0	9	9
88	R:R:M121	R:R:P207	3.35	No	Yes	0	8	9
89	R:R:I153	R:R:N122	4.25	No	No	1	9	9
90	R:R:F128	R:R:L124	7.31	No	No	0	7	8
91	R:R:L124	R:R:P207	3.28	No	Yes	0	8	9
92	R:R:I125	R:R:M152	7.29	No	No	0	8	8
93	R:R:I126	R:R:R130	5.01	No	No	2	9	9
94	R:R:I126	R:R:Y453	3.63	No	Yes	2	9	9
95	R:R:L214	R:R:S127	6.01	No	No	0	8	9
96	R:R:S127	R:R:Y215	6.36	No	No	0	9	9
97	R:R:F128	R:R:I210	3.77	No	No	0	7	8
98	R:R:F128	R:R:L214	4.87	No	No	0	7	8
99	R:R:D129	R:R:Y140	11.49	Yes	Yes	3	9	9
100	R:R:D129	R:R:R144	5.96	Yes	Yes	3	9	9
101	R:R:R130	R:R:Y453	8.23	No	Yes	2	9	9
102	R:R:T135	R:R:Y131	13.73	No	No	0	9	9
103	R:R:L214	R:R:Y131	8.21	No	No	0	8	9
104	R:R:F132	R:R:Y140	11.35	No	Yes	0	7	9
105	R:R:I218	R:R:V134	10.75	No	No	0	9	9
106	R:R:K136	R:R:T135	4.5	No	No	0	7	9
107	R:R:L138	R:R:T139	4.42	No	No	0	7	7
108	R:R:P141	R:R:Y140	5.56	No	Yes	0	7	9
109	R:R:R144	R:R:Y140	22.64	Yes	Yes	3	9	9
110	R:R:K147	R:R:L151	4.23	No	No	0	6	3
111	R:R:L151	R:R:M148	5.65	No	No	0	3	8
112	R:R:L159	R:R:L163	4.15	No	No	0	6	8
113	R:R:A165	R:R:F161	4.16	No	No	0	7	7
114	R:R:T199	R:R:W164	9.7	No	Yes	0	9	8
115	R:R:A203	R:R:W164	3.89	No	Yes	0	9	8
116	R:R:A165	R:R:P166	3.74	No	No	0	7	9
117	R:R:F170	R:R:V174	5.24	No	No	0	7	5
118	R:R:F189	R:R:W171	8.02	Yes	No	6	8	7
119	R:R:V195	R:R:W171	12.26	No	No	6	8	7
120	R:R:F173	R:R:Q172	5.86	No	No	0	6	7
121	R:R:Q172	R:R:Q188	6.4	No	No	0	7	8
122	R:R:K177	R:R:V175	4.55	No	No	0	3	5
123	R:R:Q188	R:R:T179	4.25	No	No	0	8	5
124	R:R:P181	R:R:V180	3.53	No	No	0	3	5
125	R:R:F186	R:R:V180	5.24	No	No	0	4	5
126	R:R:Q188	R:R:V180	8.6	No	No	0	8	5
127	R:R:N183	R:R:P181	6.52	No	No	0	4	3
128	R:R:N183	R:R:Q184	11.88	No	No	0	4	5
129	R:R:D432	R:R:Q184	3.92	No	No	0	3	5
130	R:R:F186	R:R:L190	4.87	No	Yes	0	4	5
131	R:R:F186	W:W:?1	31.7	No	Yes	0	4	0
132	R:R:F189	R:R:I187	5.02	Yes	Yes	0	8	7
133	R:R:I187	R:R:L190	4.28	Yes	Yes	0	7	5
134	R:R:F189	R:R:V195	9.18	Yes	No	6	8	8
135	R:R:L190	R:R:T196	7.37	Yes	No	0	5	8
136	R:R:L190	R:R:N423	4.12	Yes	No	0	5	5
137	R:R:N192	R:R:P193	4.89	No	Yes	0	7	5
138	R:R:N192	R:R:V195	5.91	No	No	0	7	8
139	R:R:F197	R:R:P193	4.33	Yes	Yes	4	7	5
140	R:R:P193	R:R:T424	6.99	Yes	No	4	5	7
141	R:R:F425	R:R:P193	7.22	No	Yes	4	6	5
142	R:R:F197	R:R:L421	4.87	Yes	No	0	7	7
143	R:R:F197	R:R:T424	10.38	Yes	No	4	7	7
144	R:R:F204	R:R:Y205	4.13	Yes	No	0	9	8
145	R:R:F204	R:R:V208	7.87	Yes	No	1	9	8
146	R:R:F204	R:R:F409	6.43	Yes	Yes	1	9	9
147	R:R:F204	R:R:W413	4.01	Yes	Yes	1	9	9
148	R:R:F204	R:R:T414	9.08	Yes	Yes	0	9	7
149	R:R:F204	R:R:N417	15.71	Yes	No	1	9	9
150	R:R:L421	R:R:Y205	8.21	No	No	0	7	8
151	R:R:L206	R:R:P207	4.93	No	Yes	0	8	9
152	R:R:F409	R:R:V208	3.93	Yes	No	1	9	8
153	R:R:I410	R:R:V208	4.61	No	No	0	8	8
154	R:R:F409	R:R:M211	3.73	Yes	No	0	9	9
155	R:R:L406	R:R:T212	4.42	No	No	0	8	7
156	R:R:I402	R:R:Y215	12.09	No	No	0	9	9
157	R:R:S219	R:R:T399	9.59	No	No	0	8	9
158	R:R:L220	R:R:R223	3.64	No	No	0	4	7
159	R:R:M391	R:R:R394	3.72	No	No	0	6	7
160	R:R:K397	R:R:R394	3.71	No	No	0	9	7
161	R:R:E395	R:R:T399	4.23	Yes	No	0	9	9
162	R:R:K397	R:R:R400	4.95	No	No	0	9	7
163	R:R:C456	R:R:T401	3.38	No	No	0	8	9
164	R:R:I405	R:R:Y453	7.25	No	Yes	0	9	9
165	R:R:F409	R:R:N445	4.83	Yes	Yes	1	9	9
166	R:R:I410	R:R:T414	9.12	No	Yes	0	8	7
167	R:R:T412	R:R:W413	3.64	No	Yes	1	9	9
168	R:R:T412	R:R:V444	4.76	No	No	0	9	6
169	R:R:N445	R:R:T412	10.24	Yes	No	1	9	9
170	R:R:N417	R:R:W413	7.91	No	Yes	1	9	9
171	R:R:C442	R:R:W413	15.67	No	Yes	0	9	9
172	R:R:N445	R:R:W413	6.78	Yes	Yes	1	9	9
173	R:R:N417	R:R:Y416	4.65	No	Yes	1	9	9
174	R:R:V420	R:R:Y416	3.79	No	Yes	1	8	9
175	R:R:Y416	R:R:Y439	9.93	Yes	Yes	1	9	7
176	R:R:C442	R:R:Y416	4.03	No	Yes	0	9	9
177	R:R:Y416	W:W:?1	5.62	Yes	Yes	1	9	0
178	R:R:M419	R:R:W435	5.82	No	Yes	0	7	6
179	R:R:V420	W:W:?1	5.1	No	Yes	1	8	0
180	R:R:C426	R:R:V422	5.12	No	No	7	7	7
181	R:R:C429	R:R:V422	3.42	No	No	7	7	7
182	R:R:N423	W:W:?1	3.76	No	Yes	0	5	0
183	R:R:F425	R:R:T424	7.78	No	No	4	6	7
184	R:R:C426	R:R:C429	7.28	No	No	7	7	7
185	R:R:I430	R:R:P431	3.39	No	No	8	6	6
186	R:R:I430	R:R:V434	6.14	No	Yes	8	6	5
187	R:R:I430	R:R:W435	21.14	No	Yes	0	6	6
188	R:R:P431	R:R:V434	3.53	No	Yes	8	6	5
189	R:R:D432	W:W:?1	10.23	No	Yes	0	3	0
190	R:R:I437	R:R:V434	4.61	No	Yes	0	5	5
191	R:R:W435	W:W:?1	19.5	Yes	Yes	0	6	0
192	R:R:Y439	R:R:Y443	11.91	Yes	Yes	1	7	9
193	R:R:N445	R:R:N449	10.9	Yes	No	1	9	9
194	R:R:C452	R:R:I448	4.91	No	No	0	9	7
195	R:R:A454	R:R:F460	4.16	No	Yes	0	9	9
196	R:R:N457	R:R:T459	5.85	No	No	2	9	8
197	R:R:F460	R:R:N457	16.92	Yes	No	2	9	9
198	R:R:F460	R:R:T459	3.89	Yes	No	2	9	8
199	R:R:H466	R:R:T463	6.85	No	No	0	6	9
200	R:R:L467	R:R:T463	4.42	No	No	0	7	9
201	R:R:F464	R:R:R465	8.55	No	No	0	9	6
202	R:R:L468	R:R:R465	9.72	No	No	0	8	6
203	R:R:C452	R:R:I405	3.27	No	No	0	9	9
204	R:R:C76	R:R:M54	3.24	No	Yes	0	8	8
205	R:R:A75	R:R:M54	3.22	No	Yes	0	9	8
206	R:R:A458	R:R:K462	3.21	No	No	0	5	6
207	R:R:T146	R:R:V66	3.17	No	No	0	6	8
208	R:R:A194	R:R:N192	3.13	No	No	0	5	7
209	R:R:C133	R:R:D129	3.11	No	Yes	0	9	9
210	R:R:S428	W:W:?1	3.09	No	Yes	0	3	0
211	R:R:M32	R:R:T29	3.01	No	No	0	6	4
212	R:R:L63	R:R:S56	3	Yes	No	0	9	9
213	R:R:L74	R:R:S119	3	Yes	No	0	9	9
214	R:R:K136	R:R:T139	3	No	No	0	7	7
215	R:R:L44	R:R:V48	2.98	No	No	0	5	5
216	R:R:L467	R:R:V59	2.98	No	No	0	7	7
217	R:R:L441	R:R:V444	2.98	No	No	0	9	6
218	R:R:I218	R:R:I402	2.94	No	No	5	9	9
219	R:R:I57	R:R:K58	2.91	Yes	No	0	9	5
220	R:R:E395	R:R:S222	2.87	Yes	No	0	9	9
221	R:R:K461	R:R:L455	2.82	No	No	0	9	8
222	R:R:A83	R:R:F84	2.77	No	No	0	5	6
223	R:R:A167	R:R:F189	2.77	No	Yes	0	8	8
224	R:R:H217	R:R:V213	2.77	No	No	0	7	5
225	R:R:C429	R:R:W435	2.61	No	Yes	0	7	6
226	R:R:A77	R:R:W157	2.59	No	No	0	9	9
227	R:R:F70	R:R:I125	2.51	Yes	No	0	8	8
228	R:R:F70	R:R:I126	2.51	Yes	No	0	8	9
229	R:R:F464	R:R:K461	2.48	No	No	0	9	9
230	R:R:S73	R:R:W157	2.47	No	No	0	9	9
231	R:R:I437	R:R:W440	2.35	No	No	0	5	9
232	R:R:E395	R:R:R396	2.33	Yes	No	0	9	7
233	R:R:Q184	R:R:Y97	2.25	No	No	0	5	5
234	R:R:D182	R:R:W98	2.23	No	Yes	0	3	9
235	R:R:H217	R:R:Y131	2.18	No	No	0	7	9
236	R:R:F170	R:R:W171	2	No	No	0	7	7
237	R:R:A149	R:R:G150	1.95	No	No	0	8	5
238	R:R:G82	R:R:V47	1.84	No	No	0	9	7
239	R:R:G49	R:R:V48	1.84	No	No	0	9	5
240	R:R:G101	R:R:V104	1.84	No	No	0	8	6
241	R:R:G176	R:R:V175	1.84	No	No	0	4	5
242	R:R:A110	R:R:A165	1.79	No	No	0	8	7
243	R:R:G198	R:R:I201	1.76	No	No	0	7	7
244	R:R:G438	R:R:I437	1.76	No	No	0	7	5
245	R:R:P415	R:R:T414	1.75	No	Yes	0	9	7
246	R:R:K136	R:R:P137	1.67	No	No	0	7	9
247	R:R:S41	R:R:V38	1.62	No	No	0	5	5
248	R:R:S160	R:R:V114	1.62	No	No	0	9	8
249	R:R:A156	R:R:I125	1.62	No	No	0	9	8
250	R:R:A408	R:R:I448	1.62	No	No	0	8	7
251	R:R:V47	R:R:V48	1.6	No	No	0	7	5
252	R:R:T37	R:R:V33	1.59	No	No	0	5	6
253	R:R:T39	R:R:V38	1.59	No	No	0	7	5
254	R:R:T46	R:R:V45	1.59	No	No	0	8	5
255	R:R:T399	R:R:V398	1.59	No	No	0	9	9
256	R:R:T401	R:R:V398	1.59	No	No	0	9	9
257	R:R:T414	R:R:V418	1.59	Yes	No	0	7	7
258	R:R:T433	R:R:V434	1.59	No	Yes	0	4	5
259	R:R:T39	R:R:T90	1.57	No	No	0	7	8
260	R:R:T145	R:R:T146	1.57	No	No	0	9	6
261	R:R:A458	R:R:N457	1.56	No	No	0	5	9
262	R:R:I218	R:R:S219	1.55	No	No	5	9	8
263	R:R:I402	R:R:S219	1.55	No	No	5	9	8
264	R:R:I80	R:R:V115	1.54	No	No	0	8	8
265	R:R:I35	R:R:T39	1.52	No	No	0	7	7
266	R:R:M148	R:R:T145	1.51	No	No	0	8	9
267	R:R:F197	R:R:G198	1.51	Yes	No	0	7	7
268	R:R:L42	R:R:S41	1.5	No	No	0	6	5
269	R:R:L163	R:R:V162	1.49	No	No	0	8	5
270	R:R:N67	R:R:T65	1.46	No	No	0	9	8
271	R:R:N68	R:R:T65	1.46	Yes	No	0	9	8
272	R:R:N87	R:R:T90	1.46	No	No	0	9	8
273	R:R:Q427	R:R:S428	1.44	No	No	0	3	3
274	R:R:I410	R:R:L406	1.43	No	No	0	8	8
275	R:R:L88	R:R:N87	1.37	No	No	0	7	9
276	R:R:N60	R:R:Q62	1.32	No	No	0	8	6
277	R:R:F34	R:R:T37	1.3	No	No	0	4	5
278	R:R:R400	R:R:T401	1.29	No	No	0	7	9
279	R:R:H466	R:R:L469	1.29	No	No	0	6	4
280	R:R:E395	R:R:R223	1.16	Yes	No	0	9	7
281	R:R:L163	R:R:W164	1.14	No	Yes	0	8	8
282	R:R:R143	R:R:Y140	1.03	No	Yes	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N50	5.105	4	0	9
2	R:R:M54	4.54	4	0	8
3	R:R:I57	6.39	4	0	9
4	R:R:L63	7.0775	4	2	9
5	R:R:N68	5.728	5	2	9
6	R:R:F70	3.49	4	0	8
7	R:R:L74	6.35	5	1	9
8	R:R:D78	7.215	4	1	9
9	R:R:Y89	8.082	5	1	8
10	R:R:Y92	8.16	4	1	8
11	R:R:W98	6.1875	8	1	9
12	R:R:W108	7.468	5	1	7
13	R:R:D112	9.5975	4	1	9
14	R:R:Y113	8.8725	4	1	9
15	R:R:D129	6.146	5	3	9
16	R:R:Y140	10.414	5	3	9
17	R:R:R144	13.1825	4	3	9
18	R:R:W164	7.296	5	0	8
19	R:R:I187	5.2625	4	0	7
20	R:R:F189	6.2475	4	6	8
21	R:R:L190	5.16	4	0	5
22	R:R:P193	5.8575	4	4	5
23	R:R:F197	5.2725	4	4	7
24	R:R:F204	7.87167	6	1	9
25	R:R:P207	3.7725	4	0	9
26	R:R:E395	2.6475	4	0	9
27	R:R:F409	4.73	4	1	9
28	R:R:W413	7.15833	6	1	9
29	R:R:T414	5.385	4	0	7
30	R:R:Y416	6.49	6	1	9
31	R:R:V434	3.9675	4	8	5
32	R:R:W435	12.2675	4	0	6
33	R:R:Y439	9.20333	6	1	7
34	R:R:Y443	11.095	4	1	9
35	R:R:N445	8.1875	4	1	9
36	R:R:Y453	5.6575	4	2	9
37	R:R:F460	6.59	6	2	9
38	W:W:?1	11.2857	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D112	R:R:S85	27.0909	8.83	Yes	No	1	9	9
2	R:R:I81	R:R:S85	46.6698	4.64	No	No	0	9	9
3	R:R:I81	R:R:S446	45.0141	9.29	No	No	0	9	9
4	R:R:D78	R:R:S446	44.5781	5.89	Yes	No	0	9	9
5	R:R:D78	R:R:N50	100	5.39	Yes	Yes	0	9	9
6	R:R:W108	R:R:Y439	10.2	5.79	Yes	Yes	1	7	7
7	R:R:Y439	R:R:Y443	22.3214	11.91	Yes	Yes	1	7	9
8	R:R:L79	R:R:N50	92.8661	4.12	No	Yes	0	9	9
9	R:R:L79	R:R:M54	90.4337	4.24	No	Yes	0	9	8
10	R:R:F72	R:R:M54	86.7339	7.46	No	Yes	0	8	8
11	R:R:F72	R:R:I57	85.487	6.28	No	Yes	0	8	9
12	R:R:I57	R:R:N68	80.571	12.74	Yes	Yes	0	9	9
13	R:R:L63	R:R:N68	15.8621	5.49	Yes	Yes	2	9	9
14	R:R:L63	R:R:N60	13.2491	13.73	Yes	No	0	9	8
15	R:R:N68	R:R:T65	37.3659	1.46	Yes	No	0	9	8
16	R:R:N67	R:R:T65	35.8975	1.46	No	No	0	9	8
17	R:R:N67	R:R:R144	16.6014	8.44	No	Yes	3	9	9
18	R:R:D129	R:R:N67	17.838	5.39	Yes	No	3	9	9
19	R:R:L71	R:R:N68	20.5294	4.12	No	Yes	2	8	9
20	R:R:L71	R:R:Y453	19.6777	3.52	No	Yes	2	8	9
21	R:R:I126	R:R:Y453	10.9256	3.63	No	Yes	2	9	9
22	R:R:D78	R:R:N449	57.2344	8.08	Yes	No	1	9	9
23	R:R:N417	R:R:Y416	38.1324	4.65	No	Yes	1	9	9
24	R:R:N417	R:R:W413	29.319	7.91	No	Yes	1	9	9
25	R:R:N445	R:R:W413	58.965	6.78	Yes	Yes	1	9	9
26	R:R:N445	R:R:N449	65.2676	10.9	Yes	No	1	9	9
27	R:R:C442	R:R:Y416	29.4518	4.03	No	Yes	0	9	9
28	R:R:C442	R:R:W413	29.353	15.67	No	Yes	0	9	9
29	R:R:Y113	R:R:Y439	39.7881	6.95	Yes	Yes	1	9	7
30	R:R:I187	R:R:Y113	19.8481	6.04	Yes	Yes	0	7	9
31	R:R:W164	R:R:Y113	72.9091	11.58	Yes	Yes	0	8	9
32	R:R:N117	R:R:S160	10.0535	4.47	No	No	0	9	9
33	R:R:N117	R:R:W164	64.7464	10.17	No	Yes	0	9	8
34	R:R:M121	R:R:N117	54.7065	8.41	No	No	0	8	9
35	R:R:M121	R:R:P207	53.245	3.35	No	Yes	0	8	9
36	R:R:F128	R:R:L124	47.3274	7.31	No	No	0	7	8
37	R:R:L124	R:R:P207	48.8195	3.28	No	Yes	0	8	9
38	R:R:F128	R:R:L214	44.4895	4.87	No	No	0	7	8
39	R:R:L214	R:R:S127	30.6613	6.01	No	No	0	8	9
40	R:R:S127	R:R:Y215	29.0907	6.36	No	No	0	9	9
41	R:R:L214	R:R:Y131	13.3513	8.21	No	No	0	8	9
42	R:R:I402	R:R:Y215	27.5066	12.09	No	No	0	9	9
43	R:R:F189	R:R:I187	13.4501	5.02	Yes	Yes	0	8	7
44	R:R:F186	W:W:?1	10.0467	31.7	No	Yes	0	4	0
45	R:R:Y416	W:W:?1	29.4518	5.62	Yes	Yes	1	9	0
46	R:R:I402	R:R:S219	22.8392	1.55	No	No	5	9	8
47	R:R:S219	R:R:T399	21.3334	9.59	No	No	0	8	9
48	R:R:T399	R:R:V398	11.5559	1.59	No	No	0	9	9
49	R:R:W435	W:W:?1	15.2455	19.5	Yes	Yes	0	6	0
50	R:R:S85	R:R:Y443	20.3318	11.45	No	Yes	1	9	9
51	R:R:D112	R:R:Y439	18.3252	5.75	Yes	Yes	1	9	7
52	R:R:Y113	R:R:Y416	45.3889	10.92	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D432	R:R:Y92	8.05	0	No	Yes	3	8	1	2
R:R:Y113	R:R:Y416	10.92	1	Yes	Yes	9	9	2	1
R:R:Y113	R:R:Y439	6.95	1	Yes	Yes	9	7	2	2
R:R:F186	R:R:V180	5.24	0	No	No	4	5	1	2
R:R:D432	R:R:Q184	3.92	0	No	No	3	5	1	2
R:R:F186	R:R:L190	4.87	0	No	Yes	4	5	1	2
R:R:F186	W:W:?1	31.7	0	No	Yes	4	0	1	0
R:R:L190	R:R:N423	4.12	0	Yes	No	5	5	2	1
R:R:N417	R:R:Y416	4.65	1	No	Yes	9	9	2	1
R:R:V420	R:R:Y416	3.79	1	No	Yes	8	9	1	1
R:R:Y416	R:R:Y439	9.93	1	Yes	Yes	9	7	1	2
R:R:C442	R:R:Y416	4.03	0	No	Yes	9	9	2	1
R:R:Y416	W:W:?1	5.62	1	Yes	Yes	9	0	1	0
R:R:M419	R:R:W435	5.82	0	No	Yes	7	6	2	1
R:R:V420	W:W:?1	5.1	1	No	Yes	8	0	1	0
R:R:N423	W:W:?1	3.76	0	No	Yes	5	0	1	0
R:R:I430	R:R:W435	21.14	8	No	Yes	6	6	2	1
R:R:D432	W:W:?1	10.23	0	No	Yes	3	0	1	0
R:R:W435	W:W:?1	19.5	0	Yes	Yes	6	0	1	0
R:R:S428	W:W:?1	3.09	0	No	Yes	3	0	1	0
R:R:C429	R:R:W435	2.61	7	No	Yes	7	6	2	1
R:R:Q427	R:R:S428	1.44	0	No	No	3	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7V6A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	251
Number of Links	282
Number of Hubs	38
Number of Links mediated by Hubs	141
Number of Communities	8
Number of Nodes involved in Communities	58
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	53
Number Of Links MetaPath	52
Number of Shortest Paths	51583
Length Of Smallest Path	3
Average Path Length	16.3643
Length of Longest Path	40
Minimum Path Strength	1.315
Average Path Strength	6.90866
Maximum Path Strength	25.6
Minimum Path Correlation	0.7
Average Path Correlation	0.923201
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	41.5042
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8382
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	5XI
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	5XI
Name	methyl 4-[4-(3-methyl-2-oxidanylidene-benzimidazol-1-yl)piperidin-1-yl]piperidine-1-carboxylate
Synonyms
Identifier
Formula	C20 H28 N4 O3
Molecular Weight	372.461
SMILES
PubChem	9864275
Formal Charge	0
Total Atoms	55
Total Chiral Atoms	0
Total Bonds	58
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>7V6A_nogp_Chain_R T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G Y W P L G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F I Q F L S N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F K K T F R H L L L C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	doi.org/10.1038/nature17188
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	doi.org/10.1038/nature25758
	6KP6	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	-	3	2020-03-11	doi.org/10.1107/S2052252520000597
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275	Gi1/β1/γ2	3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275		3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	9M4Q	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9IQS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	Muscarinic toxin 3	-	3.6	2025-07-23	To be published
	9M42	A	Orphan	Orphan	GPR139	Homo sapiens	A1L8O	-	chim(Gs-CtGq)/β1/γ2	3.2	2026-01-21	10.1038/s41467-025-66845-y
	9M42 (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	A1L8O	-		3.2	2026-01-21	10.1038/s41467-025-66845-y

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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