psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D112	8.71	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y113	15.05	Yes	Yes	1	0	9
3	L:L:?1	R:R:S116	11.78	Yes	No	1	0	8
4	L:L:?1	R:R:N117	8.81	Yes	Yes	1	0	9
5	L:L:?1	R:R:W164	8.12	Yes	Yes	1	0	8
6	L:L:?1	R:R:A203	4.5	Yes	No	0	0	9
7	L:L:?1	R:R:W413	12.19	Yes	Yes	1	0	9
8	L:L:?1	R:R:Y416	7.53	Yes	Yes	1	0	9
9	L:L:?1	R:R:N417	5.88	Yes	No	1	0	9
10	L:L:?1	R:R:C442	9.06	Yes	No	1	0	9
11	R:R:F34	R:R:T37	10.38	No	No	0	4	5
12	R:R:T39	R:R:T90	4.71	No	No	0	7	8
13	R:R:T39	R:R:W440	13.34	No	Yes	0	7	9
14	R:R:M86	R:R:S43	4.6	Yes	No	0	9	8
15	R:R:M86	R:R:T46	7.53	Yes	No	0	9	8
16	R:R:T447	R:R:T46	10.99	Yes	No	0	8	8
17	R:R:D78	R:R:N50	6.73	Yes	No	0	9	9
18	R:R:L79	R:R:N50	5.49	No	No	0	9	9
19	R:R:F464	R:R:L52	9.74	No	No	0	9	8
20	R:R:F72	R:R:M54	9.95	Yes	No	0	8	8
21	R:R:S56	R:R:T463	6.4	No	No	0	9	9
22	R:R:I57	R:R:N68	4.25	No	Yes	0	9	9
23	R:R:F72	R:R:I57	5.02	Yes	No	0	8	9
24	R:R:F72	R:R:K58	4.96	Yes	No	0	8	5
25	R:R:N60	R:R:Q62	7.92	No	No	0	8	6
26	R:R:L63	R:R:N60	8.24	No	No	0	9	8
27	R:R:Q64	R:R:R61	14.02	No	No	0	8	8
28	R:R:L63	R:R:T459	5.9	No	No	0	9	8
29	R:R:F460	R:R:L63	8.53	Yes	No	0	9	9
30	R:R:N68	R:R:T65	8.77	Yes	No	0	9	8
31	R:R:R144	R:R:V66	5.23	Yes	No	0	9	8
32	R:R:D129	R:R:N67	6.73	Yes	No	2	9	9
33	R:R:N67	R:R:R144	13.26	No	Yes	2	9	9
34	R:R:L71	R:R:N68	5.49	No	Yes	0	8	9
35	R:R:F460	R:R:N68	4.83	Yes	Yes	0	9	9
36	R:R:T146	R:R:Y69	7.49	No	No	0	6	7
37	R:R:F70	R:R:I125	5.02	Yes	No	0	8	8
38	R:R:D129	R:R:F70	4.78	Yes	Yes	0	9	8
39	R:R:A149	R:R:F70	4.16	No	Yes	0	8	8
40	R:R:F70	R:R:I153	5.02	Yes	No	0	8	9
41	R:R:C76	R:R:F72	4.19	No	Yes	0	8	8
42	R:R:N122	R:R:S73	8.94	No	No	3	9	9
43	R:R:I153	R:R:S73	4.64	No	No	0	9	9
44	R:R:S73	R:R:W157	6.18	No	Yes	3	9	9
45	R:R:D78	R:R:L74	5.43	Yes	Yes	1	9	9
46	R:R:L123	R:R:L74	5.54	No	Yes	0	9	9
47	R:R:L74	R:R:N449	5.49	Yes	No	1	9	9
48	R:R:D78	R:R:S446	11.78	Yes	No	0	9	9
49	R:R:D78	R:R:N449	9.42	Yes	No	1	9	9
50	R:R:I80	R:R:V115	7.68	No	No	0	8	8
51	R:R:I81	R:R:S85	6.19	No	No	0	9	9
52	R:R:I81	R:R:V115	6.14	No	No	0	9	8
53	R:R:I81	R:R:S446	6.19	No	No	0	9	9
54	R:R:G82	R:R:M86	6.99	No	Yes	0	9	9
55	R:R:A83	R:R:F84	5.55	No	No	0	5	6
56	R:R:D112	R:R:S85	11.78	Yes	No	0	9	9
57	R:R:M86	R:R:W440	4.65	Yes	Yes	1	9	9
58	R:R:M86	R:R:Y443	8.38	Yes	Yes	1	9	9
59	R:R:L88	R:R:W98	5.69	No	Yes	1	7	9
60	R:R:L88	R:R:W108	10.25	No	Yes	1	7	7
61	R:R:Y439	R:R:Y89	22.84	No	Yes	1	7	8
62	R:R:W440	R:R:Y89	4.82	Yes	Yes	1	9	8
63	R:R:Y443	R:R:Y89	5.96	Yes	Yes	1	9	8
64	R:R:Y89	W:W:?1	7.84	Yes	Yes	1	8	0
65	R:R:K95	R:R:V91	6.07	No	No	0	5	8
66	R:R:W98	R:R:Y92	11.58	Yes	No	0	9	8
67	R:R:Y92	W:W:?1	18.28	No	Yes	0	8	0
68	R:R:K95	R:R:P99	6.69	No	No	0	5	5
69	R:R:P99	R:R:Y97	8.34	No	No	0	5	5
70	R:R:N183	R:R:Y97	8.14	No	No	0	4	5
71	R:R:L100	R:R:W98	19.36	No	Yes	0	7	9
72	R:R:C105	R:R:W98	6.53	No	Yes	1	9	9
73	R:R:W108	R:R:W98	13.12	Yes	Yes	1	7	9
74	R:R:C185	R:R:W98	18.28	No	Yes	1	9	9
75	R:R:A102	R:R:R178	5.53	No	Yes	0	4	5
76	R:R:C105	R:R:C185	7.28	No	No	1	9	9
77	R:R:D106	R:R:R178	10.72	No	Yes	0	8	5
78	R:R:D112	R:R:W108	4.47	Yes	Yes	1	9	7
79	R:R:D112	R:R:S116	4.42	Yes	No	1	9	8
80	R:R:D112	R:R:Y443	8.05	Yes	Yes	1	9	9
81	R:R:W164	R:R:Y113	14.47	Yes	Yes	1	8	9
82	R:R:I187	R:R:Y113	8.46	Yes	Yes	1	7	9
83	R:R:Y113	R:R:Y416	10.92	Yes	Yes	1	9	9
84	R:R:M121	R:R:N117	5.61	No	Yes	0	8	9
85	R:R:N117	R:R:S160	4.47	Yes	No	0	9	9
86	R:R:L163	R:R:N117	4.12	No	Yes	1	8	9
87	R:R:N117	R:R:W164	9.04	Yes	Yes	1	9	8
88	R:R:A118	R:R:W157	9.08	No	Yes	0	9	9
89	R:R:F409	R:R:V120	5.24	Yes	No	0	9	9
90	R:R:N122	R:R:W157	5.65	No	Yes	3	9	9
91	R:R:L123	R:R:Y453	7.03	No	Yes	0	9	9
92	R:R:F128	R:R:L124	4.87	No	No	0	7	8
93	R:R:L124	R:R:P207	4.93	No	No	0	8	9
94	R:R:I126	R:R:R130	6.26	No	No	0	9	9
95	R:R:M211	R:R:S127	4.6	No	No	4	9	9
96	R:R:L214	R:R:S127	6.01	Yes	No	0	8	9
97	R:R:S127	R:R:Y215	15.26	No	Yes	4	9	9
98	R:R:F128	R:R:L214	8.53	No	Yes	0	7	8
99	R:R:D129	R:R:Y140	8.05	Yes	Yes	2	9	9
100	R:R:D129	R:R:R144	9.53	Yes	Yes	2	9	9
101	R:R:R130	R:R:Y215	7.2	No	Yes	0	9	9
102	R:R:R130	R:R:Y453	7.2	No	Yes	0	9	9
103	R:R:F132	R:R:Y131	5.16	No	Yes	0	7	9
104	R:R:T135	R:R:Y131	12.48	No	Yes	0	9	9
105	R:R:L214	R:R:Y131	16.41	Yes	Yes	0	8	9
106	R:R:H217	R:R:Y131	5.44	No	Yes	0	7	9
107	R:R:F132	R:R:K136	6.2	No	No	0	7	7
108	R:R:F132	R:R:Y140	13.41	No	Yes	0	7	9
109	R:R:C133	R:R:Y140	4.03	No	Yes	2	9	9
110	R:R:C133	R:R:R144	4.18	No	Yes	2	9	9
111	R:R:K136	R:R:T139	4.5	No	No	0	7	7
112	R:R:P141	R:R:Y140	4.17	No	Yes	0	7	9
113	R:R:R144	R:R:Y140	14.4	Yes	Yes	2	9	9
114	R:R:A165	R:R:F161	8.32	No	No	0	7	7
115	R:R:L163	R:R:W164	10.25	No	Yes	1	8	8
116	R:R:T199	R:R:W164	7.28	No	Yes	0	9	8
117	R:R:A167	R:R:F189	4.16	No	Yes	0	8	8
118	R:R:I168	R:R:I187	4.42	No	Yes	1	8	7
119	R:R:F189	R:R:I168	5.02	Yes	No	1	8	8
120	R:R:Q188	R:R:W171	7.67	Yes	No	0	8	7
121	R:R:F189	R:R:W171	16.04	Yes	No	0	8	7
122	R:R:F173	R:R:Q172	8.2	No	No	0	6	7
123	R:R:Q172	R:R:R178	10.51	No	Yes	0	7	5
124	R:R:K177	R:R:T179	4.5	No	No	0	3	5
125	R:R:R178	R:R:V180	6.54	Yes	Yes	0	5	5
126	R:R:Q188	R:R:T179	9.92	Yes	No	0	8	5
127	R:R:F186	R:R:V180	7.87	No	Yes	0	4	5
128	R:R:Q188	R:R:V180	5.73	Yes	Yes	0	8	5
129	R:R:N183	R:R:Q184	5.28	No	No	0	4	5
130	R:R:F186	W:W:?1	27.13	No	Yes	0	4	0
131	R:R:F189	R:R:I187	7.54	Yes	Yes	1	8	7
132	R:R:I187	R:R:L190	4.28	Yes	No	0	7	5
133	R:R:F189	R:R:V195	5.24	Yes	No	0	8	8
134	R:R:Q427	R:R:S191	8.66	No	No	0	3	7
135	R:R:N192	R:R:P193	6.52	No	No	0	7	5
136	R:R:T196	R:R:T424	10.99	No	No	0	8	7
137	R:R:F197	R:R:L421	7.31	No	No	0	7	7
138	R:R:F197	R:R:F425	4.29	No	No	0	7	6
139	R:R:F204	R:R:Y205	10.32	Yes	Yes	1	9	8
140	R:R:F204	R:R:V208	10.49	Yes	Yes	1	9	8
141	R:R:F204	R:R:F409	5.36	Yes	Yes	1	9	9
142	R:R:F204	R:R:T414	5.19	Yes	No	0	9	7
143	R:R:F204	R:R:N417	16.92	Yes	No	1	9	9
144	R:R:N417	R:R:Y205	4.65	No	Yes	1	9	8
145	R:R:L421	R:R:Y205	5.86	No	Yes	0	7	8
146	R:R:F409	R:R:V208	5.24	Yes	Yes	1	9	8
147	R:R:M211	R:R:Y215	4.79	No	Yes	4	9	9
148	R:R:I402	R:R:Y215	7.25	No	Yes	0	9	9
149	R:R:I405	R:R:Y215	4.84	No	Yes	0	9	9
150	R:R:E395	R:R:R223	20.93	No	No	0	9	7
151	R:R:R396	R:R:R400	4.26	No	No	0	7	7
152	R:R:C456	R:R:T401	6.76	No	No	0	8	9
153	R:R:L407	R:R:L411	6.92	No	No	0	8	5
154	R:R:F409	R:R:W413	8.02	Yes	Yes	1	9	9
155	R:R:I410	R:R:T414	4.56	No	No	0	8	7
156	R:R:T412	R:R:W413	4.85	No	Yes	1	9	9
157	R:R:N445	R:R:T412	14.62	No	No	1	9	9
158	R:R:C442	R:R:W413	6.53	No	Yes	1	9	9
159	R:R:N445	R:R:W413	14.69	No	Yes	1	9	9
160	R:R:V420	R:R:Y416	8.83	No	Yes	0	8	9
161	R:R:W435	R:R:Y416	4.82	Yes	Yes	1	6	9
162	R:R:C442	R:R:Y416	4.03	No	Yes	1	9	9
163	R:R:I430	R:R:M419	4.37	Yes	No	1	6	7
164	R:R:M419	R:R:W435	6.98	No	Yes	1	7	6
165	R:R:I430	R:R:N423	7.08	Yes	Yes	1	6	5
166	R:R:N423	R:R:W435	9.04	Yes	Yes	1	5	6
167	R:R:N423	W:W:?1	6.12	Yes	Yes	1	5	0
168	R:R:C426	R:R:C429	7.28	No	No	0	7	7
169	R:R:I430	R:R:V434	4.61	Yes	No	0	6	5
170	R:R:I430	R:R:W435	10.57	Yes	Yes	1	6	6
171	R:R:P431	R:R:V434	5.3	No	No	0	6	5
172	R:R:D432	W:W:?1	6.05	No	Yes	0	3	0
173	R:R:W435	W:W:?1	33.83	Yes	Yes	1	6	0
174	R:R:Y439	R:R:Y443	4.96	No	Yes	1	7	9
175	R:R:Y439	W:W:?1	4.35	No	Yes	1	7	0
176	R:R:W440	R:R:Y443	8.68	Yes	Yes	1	9	9
177	R:R:N445	R:R:N449	4.09	No	No	1	9	9
178	R:R:C452	R:R:Y453	4.03	No	Yes	0	9	9
179	R:R:A454	R:R:F460	5.55	No	Yes	0	9	9
180	R:R:N457	R:R:T459	4.39	No	No	0	9	8
181	R:R:F460	R:R:S56	3.96	Yes	No	0	9	9
182	R:R:F464	R:R:S56	3.96	No	No	0	9	9
183	R:R:F161	R:R:V114	3.93	No	No	0	7	8
184	R:R:F425	R:R:T424	3.89	No	No	0	6	7
185	R:R:S436	R:R:Y89	3.82	No	Yes	0	6	8
186	R:R:F170	R:R:L169	3.65	No	No	0	7	6
187	R:R:F403	R:R:L407	3.65	No	No	0	8	8
188	R:R:I93	R:R:Y89	3.63	No	Yes	0	7	8
189	R:R:I218	R:R:Y131	3.63	No	Yes	0	9	9
190	R:R:I201	R:R:Y205	3.63	No	Yes	0	7	8
191	R:R:P450	R:R:V53	3.53	No	No	0	9	9
192	R:R:P181	R:R:V180	3.53	No	Yes	0	3	5
193	R:R:L71	R:R:Y453	3.52	No	Yes	0	8	9
194	R:R:L406	R:R:Y215	3.52	No	Yes	0	8	9
195	R:R:F186	R:R:Q184	3.51	No	No	0	4	5
196	R:R:P193	R:R:T424	3.5	No	No	0	5	7
197	R:R:L109	R:R:W108	3.42	No	Yes	0	8	7
198	R:R:G438	R:R:L441	3.42	No	No	0	7	9
199	R:R:A75	R:R:V53	3.39	No	No	0	9	9
200	R:R:L138	R:R:P137	3.28	No	No	0	7	9
201	R:R:L206	R:R:P207	3.28	No	No	0	8	9
202	R:R:L441	R:R:P415	3.28	No	No	0	9	9
203	R:R:N50	R:R:P450	3.26	No	No	0	9	9
204	R:R:A36	R:R:I94	3.25	No	Yes	0	6	7
205	R:R:S160	R:R:V114	3.23	No	No	0	9	8
206	R:R:S222	R:R:V398	3.23	No	No	0	9	9
207	R:R:F170	R:R:F173	3.22	No	No	0	7	6
208	R:R:A110	R:R:L169	3.15	No	No	0	8	6
209	R:R:I430	R:R:V422	3.07	Yes	No	0	6	7
210	R:R:I448	R:R:T447	3.04	No	Yes	0	7	8
211	R:R:M148	R:R:T145	3.01	No	No	0	8	9
212	R:R:L74	R:R:S119	3	Yes	No	0	9	9
213	R:R:K147	R:R:T145	3	No	No	0	6	9
214	R:R:L220	R:R:S219	3	No	No	0	4	8
215	R:R:N87	R:R:S43	2.98	No	No	0	9	8
216	R:R:L79	R:R:V47	2.98	No	No	0	9	7
217	R:R:L55	R:R:V59	2.98	No	No	0	6	7
218	R:R:L100	R:R:V104	2.98	No	No	0	7	6
219	R:R:L111	R:R:V115	2.98	No	No	0	6	8
220	R:R:I51	R:R:M54	2.92	No	No	0	7	8
221	R:R:I125	R:R:M152	2.92	No	No	0	8	8
222	R:R:F170	R:R:P166	2.89	No	No	0	7	9
223	R:R:D432	R:R:T433	2.89	No	No	0	3	4
224	R:R:E395	R:R:S222	2.87	No	No	0	9	9
225	R:R:I51	R:R:L55	2.85	No	No	0	7	6
226	R:R:I210	R:R:L124	2.85	No	No	0	8	8
227	R:R:I210	R:R:L206	2.85	No	No	0	8	8
228	R:R:I210	R:R:L214	2.85	No	Yes	0	8	8
229	R:R:H217	R:R:V213	2.77	No	No	0	7	5
230	R:R:A200	R:R:Y205	2.67	No	Yes	0	8	8
231	R:R:N423	R:R:Q427	2.64	Yes	No	0	5	3
232	R:R:A77	R:R:W157	2.59	No	Yes	0	9	9
233	R:R:L220	R:R:R223	2.43	No	No	0	4	7
234	R:R:A149	R:R:G150	1.95	No	No	0	8	5
235	R:R:G40	R:R:S43	1.86	No	No	0	6	8
236	R:R:G49	R:R:V48	1.84	No	No	0	9	5
237	R:R:G101	R:R:V104	1.84	No	No	0	8	6
238	R:R:P415	R:R:T414	1.75	No	No	0	9	7
239	R:R:G438	R:R:M419	1.75	No	No	0	7	7
240	R:R:C426	R:R:S428	1.72	No	No	0	7	3
241	R:R:G49	R:R:L52	1.71	No	No	0	9	8
242	R:R:A83	R:R:V47	1.7	No	No	0	5	7
243	R:R:A221	R:R:V134	1.7	No	No	0	8	9
244	R:R:A221	R:R:T135	1.68	No	No	0	8	9
245	R:R:K136	R:R:P137	1.67	No	No	0	7	9
246	R:R:C429	R:R:I430	1.64	No	Yes	0	7	6
247	R:R:S41	R:R:V38	1.62	No	No	0	5	5
248	R:R:A156	R:R:I125	1.62	No	No	0	9	8
249	R:R:A451	R:R:I448	1.62	No	No	0	7	7
250	R:R:V208	R:R:V209	1.6	Yes	No	0	8	5
251	R:R:T37	R:R:V38	1.59	No	No	0	5	5
252	R:R:T447	R:R:V45	1.59	Yes	No	0	8	5
253	R:R:T146	R:R:V66	1.59	No	No	0	6	8
254	R:R:T212	R:R:V208	1.59	No	Yes	0	7	8
255	R:R:T399	R:R:V398	1.59	No	No	0	9	9
256	R:R:T412	R:R:V444	1.59	No	No	0	9	6
257	R:R:T447	R:R:V444	1.59	Yes	No	0	8	6
258	R:R:A451	R:R:L455	1.58	No	No	0	7	8
259	R:R:A194	R:R:N192	1.56	No	No	0	5	7
260	R:R:I437	R:R:S436	1.55	No	No	0	5	6
261	R:R:I94	R:R:V33	1.54	Yes	No	0	7	6
262	R:R:I35	R:R:T39	1.52	No	No	0	7	7
263	R:R:I216	R:R:T212	1.52	No	No	0	4	7
264	R:R:A392	R:R:E395	1.51	No	No	0	5	9
265	R:R:L42	R:R:S41	1.5	No	No	0	6	5
266	R:R:L44	R:R:V47	1.49	No	No	0	5	7
267	R:R:L107	R:R:V103	1.49	No	No	0	7	5
268	R:R:I35	R:R:I94	1.47	No	Yes	0	7	7
269	R:R:I93	R:R:I94	1.47	No	Yes	0	7	7
270	R:R:Q188	R:R:V175	1.43	Yes	No	0	8	5
271	R:R:I216	R:R:L220	1.43	No	No	0	4	4
272	R:R:I410	R:R:L411	1.43	No	No	0	8	5
273	R:R:L151	R:R:M152	1.41	No	No	0	3	8
274	R:R:L107	R:R:L169	1.38	No	No	0	7	6
275	R:R:A393	R:R:R396	1.38	No	No	0	6	7
276	R:R:R394	R:R:S224	1.32	No	No	0	7	6
277	R:R:R225	R:R:V226	1.31	No	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.163	10	1	0
2	R:R:N68	5.835	4	0	9
3	R:R:F70	4.745	4	0	8
4	R:R:F72	6.03	4	0	8
5	R:R:L74	4.865	4	1	9
6	R:R:D78	8.34	4	1	9
7	R:R:M86	6.43	5	1	9
8	R:R:Y89	8.15167	6	1	8
9	R:R:I94	1.9325	4	0	7
10	R:R:W98	12.4267	6	1	9
11	R:R:W108	7.815	4	1	7
12	R:R:D112	7.486	5	1	9
13	R:R:Y113	12.225	4	1	9
14	R:R:N117	6.41	5	1	9
15	R:R:D129	7.2725	4	2	9
16	R:R:Y131	8.624	5	0	9
17	R:R:Y140	8.812	5	2	9
18	R:R:R144	9.32	5	2	9
19	R:R:W157	5.875	4	3	9
20	R:R:W164	9.832	5	1	8
21	R:R:R178	8.325	4	0	5
22	R:R:V180	5.9175	4	0	5
23	R:R:I187	6.175	4	1	7
24	R:R:Q188	6.1875	4	0	8
25	R:R:F189	7.6	5	1	8
26	R:R:F204	9.656	5	1	9
27	R:R:Y205	5.426	5	1	8
28	R:R:V208	4.73	4	1	8
29	R:R:L214	8.45	4	0	8
30	R:R:Y215	7.14333	6	4	9
31	R:R:F409	5.965	4	1	9
32	R:R:W413	9.256	5	1	9
33	R:R:Y416	7.226	5	1	9
34	R:R:N423	6.22	4	1	5
35	R:R:I430	5.22333	6	1	6
36	R:R:W435	13.048	5	1	6
37	R:R:W440	7.8725	4	1	9
38	R:R:Y443	7.206	5	1	9
39	R:R:T447	4.3025	4	0	8
40	R:R:Y453	5.445	4	0	9
41	R:R:F460	5.7175	4	0	9
42	W:W:?1	14.8	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D112	25.8816	8.71	Yes	Yes	1	0	9
2	R:R:D112	R:R:Y443	29.4614	8.05	Yes	Yes	1	9	9
3	R:R:M86	R:R:Y443	14.2872	8.38	Yes	Yes	1	9	9
4	L:L:?1	R:R:W413	59.6228	12.19	Yes	Yes	1	0	9
5	R:R:N445	R:R:W413	86.1081	14.69	No	Yes	1	9	9
6	R:R:N445	R:R:N449	91.8679	4.09	No	No	1	9	9
7	R:R:D78	R:R:N50	15.4787	6.73	Yes	No	0	9	9
8	R:R:L74	R:R:N449	82.6459	5.49	Yes	No	1	9	9
9	R:R:L123	R:R:L74	100	5.54	No	Yes	0	9	9
10	R:R:L123	R:R:Y453	99.0863	7.03	No	Yes	0	9	9
11	R:R:L71	R:R:Y453	37.6683	3.52	No	Yes	0	8	9
12	R:R:L71	R:R:N68	36.2684	5.49	No	Yes	0	8	9
13	R:R:F460	R:R:N68	21.3026	4.83	Yes	Yes	0	9	9
14	R:R:F460	R:R:S56	10.0609	3.96	Yes	No	0	9	9
15	R:R:I57	R:R:N68	13.1011	4.25	No	Yes	0	9	9
16	R:R:F72	R:R:I57	11.6905	5.02	Yes	No	0	8	9
17	R:R:R130	R:R:Y453	72.7666	7.2	No	Yes	0	9	9
18	R:R:R130	R:R:Y215	70.608	7.2	No	Yes	0	9	9
19	R:R:S127	R:R:Y215	65.0566	15.26	No	Yes	4	9	9
20	R:R:L214	R:R:S127	64.0628	6.01	Yes	No	0	8	9
21	R:R:L214	R:R:Y131	52.4471	16.41	Yes	Yes	0	8	9
22	R:R:F132	R:R:Y131	42.835	5.16	No	Yes	0	7	9
23	R:R:F132	R:R:Y140	35.6486	13.41	No	Yes	0	7	9
24	R:R:D129	R:R:Y140	23.5734	8.05	Yes	Yes	2	9	9
25	R:R:D129	R:R:F70	21.0301	4.78	Yes	Yes	0	9	8
26	R:R:F70	R:R:I153	10.0609	5.02	Yes	No	0	8	9
27	R:R:D112	R:R:S85	21.9812	11.78	Yes	No	0	9	9
28	R:R:I81	R:R:S85	21.5003	6.19	No	No	0	9	9
29	R:R:I81	R:R:S446	19.5555	6.19	No	No	0	9	9
30	R:R:D112	R:R:W108	13.9987	4.47	Yes	Yes	1	9	7
31	R:R:W108	R:R:W98	10.2746	13.12	Yes	Yes	1	7	9
32	R:R:Y443	R:R:Y89	15.062	5.96	Yes	Yes	1	9	8
33	L:L:?1	R:R:Y416	32.3734	7.53	Yes	Yes	1	0	9
34	R:R:W435	R:R:Y416	54.5042	4.82	Yes	Yes	1	6	9
35	R:R:W435	W:W:?1	40.639	33.83	Yes	Yes	1	6	0
36	R:R:F186	W:W:?1	44.6623	27.13	No	Yes	0	4	0
37	R:R:F186	R:R:Q184	13.5873	3.51	No	No	0	4	5
38	R:R:N183	R:R:Q184	11.3486	5.28	No	No	0	4	5
39	R:R:F186	R:R:V180	30.6369	7.87	No	Yes	0	4	5
40	R:R:R178	R:R:V180	24.252	6.54	Yes	Yes	0	5	5
41	L:L:?1	R:R:Y113	11.1081	15.05	Yes	Yes	1	0	9
42	R:R:I187	R:R:Y113	11.9577	8.46	Yes	Yes	1	7	9
43	R:R:F409	R:R:W413	28.0562	8.02	Yes	Yes	1	9	9
44	R:R:Q172	R:R:R178	17.9205	10.51	No	Yes	0	7	5
45	R:R:F173	R:R:Q172	15.6925	8.2	No	No	0	6	7
46	L:L:?1	R:R:N417	22.4193	5.88	Yes	No	1	0	9
47	R:R:N417	R:R:Y205	11.8669	4.65	No	Yes	1	9	8
48	R:R:L421	R:R:Y205	14.0094	5.86	No	Yes	0	7	8
49	R:R:F197	R:R:L421	12.337	7.31	No	No	0	7	7
50	R:R:F197	R:R:F425	10.6059	4.29	No	No	0	7	6
51	R:R:F409	R:R:V208	15.3024	5.24	Yes	Yes	1	9	8
52	R:R:T212	R:R:V208	19.1173	1.59	No	Yes	0	7	8
53	R:R:I216	R:R:T212	17.2312	1.52	No	No	0	4	7
54	R:R:I216	R:R:L220	15.3345	1.43	No	No	0	4	4
55	R:R:L220	R:R:R223	11.5089	2.43	No	No	0	4	7
56	R:R:I430	R:R:W435	14.1323	10.57	Yes	Yes	1	6	6
57	R:R:F170	R:R:F173	13.4537	3.22	No	No	0	7	6
58	R:R:D78	R:R:S446	19.3791	11.78	Yes	No	0	9	9
59	R:R:D78	R:R:L74	19.0586	5.43	Yes	Yes	1	9	9
60	R:R:Y89	W:W:?1	12.6843	7.84	Yes	Yes	1	8	0
61	R:R:C442	R:R:Y416	23.162	4.03	No	Yes	1	9	9
62	R:R:C442	R:R:W413	23.4826	6.53	No	Yes	1	9	9
63	R:R:F204	R:R:F409	10.5471	5.36	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D112	8.71	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y113	15.05	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:S116	11.78	1	Yes	No	0	8	0	1
L:L:?1	R:R:N117	8.81	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:W164	8.12	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:A203	4.5	1	Yes	No	0	9	0	1
L:L:?1	R:R:W413	12.19	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y416	7.53	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:N417	5.88	1	Yes	No	0	9	0	1
L:L:?1	R:R:C442	9.06	1	Yes	No	0	9	0	1
R:R:D112	R:R:S85	11.78	1	Yes	No	9	9	1	2
R:R:D112	R:R:W108	4.47	1	Yes	Yes	9	7	1	2
R:R:D112	R:R:S116	4.42	1	Yes	No	9	8	1	1
R:R:D112	R:R:Y443	8.05	1	Yes	Yes	9	9	1	2
R:R:W164	R:R:Y113	14.47	1	Yes	Yes	8	9	1	1
R:R:I187	R:R:Y113	8.46	1	Yes	Yes	7	9	2	1
R:R:Y113	R:R:Y416	10.92	1	Yes	Yes	9	9	1	1
R:R:M121	R:R:N117	5.61	0	No	Yes	8	9	2	1
R:R:N117	R:R:S160	4.47	1	Yes	No	9	9	1	2
R:R:L163	R:R:N117	4.12	1	No	Yes	8	9	2	1
R:R:N117	R:R:W164	9.04	1	Yes	Yes	9	8	1	1
R:R:L163	R:R:W164	10.25	1	No	Yes	8	8	2	1
R:R:T199	R:R:W164	7.28	0	No	Yes	9	8	2	1
R:R:F204	R:R:Y205	10.32	1	Yes	Yes	9	8	2	2
R:R:F204	R:R:F409	5.36	1	Yes	Yes	9	9	2	2
R:R:F204	R:R:N417	16.92	1	Yes	No	9	9	2	1
R:R:N417	R:R:Y205	4.65	1	No	Yes	9	8	1	2
R:R:F409	R:R:W413	8.02	1	Yes	Yes	9	9	2	1
R:R:T412	R:R:W413	4.85	1	No	Yes	9	9	2	1
R:R:N445	R:R:T412	14.62	1	No	No	9	9	2	2
R:R:C442	R:R:W413	6.53	1	No	Yes	9	9	1	1
R:R:N445	R:R:W413	14.69	1	No	Yes	9	9	2	1
R:R:V420	R:R:Y416	8.83	0	No	Yes	8	9	2	1
R:R:W435	R:R:Y416	4.82	1	Yes	Yes	6	9	2	1
R:R:C442	R:R:Y416	4.03	1	No	Yes	9	9	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Y439	R:R:Y89	22.84	1	No	Yes	7	8	1	1
R:R:W440	R:R:Y89	4.82	1	Yes	Yes	9	8	2	1
R:R:Y443	R:R:Y89	5.96	1	Yes	Yes	9	8	2	1
R:R:Y89	W:W:?1	7.84	1	Yes	Yes	8	0	1	0
R:R:W98	R:R:Y92	11.58	1	Yes	No	9	8	2	1
R:R:Y92	W:W:?1	18.28	0	No	Yes	8	0	1	0
R:R:F186	R:R:V180	7.87	0	No	Yes	4	5	1	2
R:R:F186	W:W:?1	27.13	0	No	Yes	4	0	1	0
R:R:W435	R:R:Y416	4.82	1	Yes	Yes	6	9	1	2
R:R:I430	R:R:M419	4.37	1	Yes	No	6	7	2	2
R:R:M419	R:R:W435	6.98	1	No	Yes	7	6	2	1
R:R:I430	R:R:N423	7.08	1	Yes	Yes	6	5	2	1
R:R:N423	R:R:W435	9.04	1	Yes	Yes	5	6	1	1
R:R:N423	W:W:?1	6.12	1	Yes	Yes	5	0	1	0
R:R:I430	R:R:W435	10.57	1	Yes	Yes	6	6	2	1
R:R:D432	W:W:?1	6.05	0	No	Yes	3	0	1	0
R:R:W435	W:W:?1	33.83	1	Yes	Yes	6	0	1	0
R:R:Y439	R:R:Y443	4.96	1	No	Yes	7	9	1	2
R:R:Y439	W:W:?1	4.35	1	No	Yes	7	0	1	0
R:R:W440	R:R:Y443	8.68	1	Yes	Yes	9	9	2	2
R:R:S436	R:R:Y89	3.82	0	No	Yes	6	8	2	1
R:R:I93	R:R:Y89	3.63	0	No	Yes	7	8	2	1
R:R:F186	R:R:Q184	3.51	0	No	No	4	5	1	2
R:R:D432	R:R:T433	2.89	0	No	No	3	4	1	2
R:R:N423	R:R:Q427	2.64	1	Yes	No	5	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TRP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.02
Number of Linked Nodes	249
Number of Links	277
Number of Hubs	42
Number of Links mediated by Hubs	159
Number of Communities	4
Number of Nodes involved in Communities	49
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	39434
Length Of Smallest Path	3
Average Path Length	13.4245
Length of Longest Path	32
Minimum Path Strength	1.435
Average Path Strength	7.8522
Maximum Path Strength	30.48
Minimum Path Correlation	0.7
Average Path Correlation	0.916712
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.7983
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.3297
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IXO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	IXO
Name	4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium
Synonyms	Iperoxo
Identifier
Formula	C10 H17 N2 O2
Molecular Weight	197.254
SMILES
PubChem	10104167
Formal Charge	1
Total Atoms	31
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	0


Code	IUE
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	IUE
Name	3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
Synonyms
Identifier
Formula	C13 H14 Cl N3 O2 S
Molecular Weight	311.787
SMILES
PubChem	11536903
Formal Charge	0
Total Atoms	34
Total Chiral Atoms	0
Total Bonds	36
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>7TRP_nogp_Chain_R V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G Y W P L G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F I Q F L S N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F K K T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	10.1038/s41467-023-41199-5
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	10.2139/ssrn.4034884
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	10.2139/ssrn.4034884
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	10.2139/ssrn.4034884
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	10.2139/ssrn.4034884
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	10.1038/s41586-022-05489-0
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	10.1038/s41594-022-00796-6
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	PubChem 9864275	-	Gi1/β1/γ2	3.6	2022-05-11	10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	PubChem 9864275	-		3.6	2022-05-11	10.1038/s41467-022-30595-y
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	10.1038/s41467-022-30595-y
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	PubChem 57664406	Gi1/β1/γ2	3.4	2022-05-11	10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	PubChem 57664406		3.4	2022-05-11	10.1038/s41467-022-30595-y
	6KP6	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	-	3	2020-03-11	10.1107/S2052252520000597
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	10.1038/nature25758
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	10.1038/s41598-017-18570-w
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	10.1038/s41467-017-00630-4
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	10.1038/nature17188

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