psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F34	R:R:V38	6.55	No	No	0	4	5
2	R:R:T39	R:R:T90	12.56	No	No	0	7	8
3	R:R:T39	R:R:W440	10.92	No	Yes	0	7	9
4	R:R:L42	R:R:W440	6.83	No	Yes	0	6	9
5	R:R:N87	R:R:S43	5.96	No	No	0	9	8
6	R:R:N50	R:R:T46	4.39	No	Yes	0	9	8
7	R:R:G82	R:R:T46	3.64	No	Yes	1	9	8
8	R:R:M86	R:R:T46	6.02	Yes	Yes	1	9	8
9	R:R:T447	R:R:T46	12.56	No	Yes	0	8	8
10	R:R:D78	R:R:N50	6.73	Yes	No	0	9	9
11	R:R:N50	R:R:P450	4.89	No	No	0	9	9
12	R:R:I51	R:R:M54	4.37	No	No	0	7	8
13	R:R:I51	R:R:L79	7.14	No	No	0	7	9
14	R:R:F464	R:R:L52	6.09	Yes	No	0	9	8
15	R:R:F464	R:R:V53	3.93	Yes	No	0	9	9
16	R:R:F72	R:R:M54	9.95	No	No	0	8	8
17	R:R:S56	R:R:T463	6.4	No	Yes	0	9	9
18	R:R:F464	R:R:S56	5.28	Yes	No	0	9	9
19	R:R:F460	R:R:I57	5.02	Yes	No	0	9	9
20	R:R:N60	R:R:Q62	3.96	No	No	0	8	6
21	R:R:L63	R:R:N60	10.98	Yes	No	3	9	8
22	R:R:N60	R:R:T463	4.39	No	Yes	3	8	9
23	R:R:Q64	R:R:R61	11.68	No	No	0	8	8
24	R:R:L63	R:R:T459	7.37	Yes	No	0	9	8
25	R:R:F460	R:R:L63	9.74	Yes	Yes	0	9	9
26	R:R:L63	R:R:T463	5.9	Yes	Yes	3	9	9
27	R:R:N68	R:R:T65	7.31	No	No	0	9	8
28	R:R:R144	R:R:V66	7.85	Yes	No	0	9	8
29	R:R:D129	R:R:N67	6.73	Yes	No	2	9	9
30	R:R:N67	R:R:R144	12.05	No	Yes	2	9	9
31	R:R:L71	R:R:N68	4.12	No	No	0	8	9
32	R:R:F460	R:R:N68	7.25	Yes	No	0	9	9
33	R:R:T146	R:R:Y69	3.75	No	No	0	6	7
34	R:R:F70	R:R:I125	5.02	Yes	No	0	8	8
35	R:R:F70	R:R:I126	3.77	Yes	No	0	8	9
36	R:R:D129	R:R:F70	3.58	Yes	Yes	0	9	8
37	R:R:F70	R:R:M152	3.73	Yes	No	0	8	8
38	R:R:L71	R:R:Y453	3.52	No	Yes	0	8	9
39	R:R:C76	R:R:F72	4.19	No	No	0	8	8
40	R:R:N122	R:R:S73	8.94	No	No	1	9	9
41	R:R:I153	R:R:S73	7.74	No	No	0	9	9
42	R:R:S73	R:R:W157	6.18	No	Yes	1	9	9
43	R:R:D78	R:R:L74	8.14	Yes	Yes	1	9	9
44	R:R:L74	R:R:N122	4.12	Yes	No	1	9	9
45	R:R:L123	R:R:L74	5.54	No	Yes	1	9	9
46	R:R:L74	R:R:N449	8.24	Yes	Yes	1	9	9
47	R:R:D78	R:R:S119	4.42	Yes	No	0	9	9
48	R:R:D78	R:R:S446	10.31	Yes	No	0	9	9
49	R:R:D78	R:R:N449	8.08	Yes	Yes	1	9	9
50	R:R:I80	R:R:V115	7.68	No	No	0	8	8
51	R:R:G82	R:R:I81	3.53	No	Yes	0	9	9
52	R:R:I81	R:R:S85	6.19	Yes	No	0	9	9
53	R:R:I81	R:R:V115	4.61	Yes	No	0	9	8
54	R:R:I81	R:R:S116	4.64	Yes	No	0	9	8
55	R:R:I81	R:R:S446	10.84	Yes	No	0	9	9
56	R:R:G82	R:R:M86	5.24	No	Yes	1	9	9
57	R:R:A83	R:R:F84	4.16	No	No	0	5	6
58	R:R:D112	R:R:S85	10.31	Yes	No	1	9	9
59	R:R:S85	R:R:Y443	6.36	No	Yes	1	9	9
60	R:R:M86	R:R:W440	6.98	Yes	Yes	1	9	9
61	R:R:M86	R:R:Y443	7.18	Yes	Yes	1	9	9
62	R:R:L88	R:R:W98	5.69	No	Yes	1	7	9
63	R:R:L88	R:R:W108	10.25	No	Yes	1	7	7
64	R:R:Y89	R:R:Y92	9.93	Yes	No	0	8	8
65	R:R:W108	R:R:Y89	5.79	Yes	Yes	1	7	8
66	R:R:Y439	R:R:Y89	22.84	Yes	Yes	1	7	8
67	R:R:Y443	R:R:Y89	4.96	Yes	Yes	1	9	8
68	R:R:K95	R:R:V91	4.55	No	No	4	5	8
69	R:R:P99	R:R:V91	3.53	Yes	No	4	5	8
70	R:R:W98	R:R:Y92	9.65	Yes	No	0	9	8
71	R:R:I93	R:R:S436	7.74	No	No	0	7	6
72	R:R:K95	R:R:P99	11.71	No	Yes	4	5	5
73	R:R:P99	R:R:Y97	4.17	Yes	No	0	5	5
74	R:R:L100	R:R:W98	17.08	No	Yes	0	7	9
75	R:R:C105	R:R:W98	3.92	No	Yes	1	9	9
76	R:R:W108	R:R:W98	14.06	Yes	Yes	1	7	9
77	R:R:C185	R:R:W98	14.37	No	Yes	1	9	9
78	R:R:A102	R:R:R178	4.15	No	Yes	0	4	5
79	R:R:C105	R:R:C185	7.28	No	No	1	9	9
80	R:R:D106	R:R:Q172	3.92	No	No	5	8	7
81	R:R:D106	R:R:R178	8.34	No	Yes	5	8	5
82	R:R:L109	R:R:W108	6.83	No	Yes	0	8	7
83	R:R:D112	R:R:W108	5.58	Yes	Yes	1	9	7
84	R:R:C185	R:R:L109	4.76	No	No	0	9	8
85	R:R:I187	R:R:L109	5.71	Yes	No	0	7	8
86	R:R:A110	R:R:L169	4.73	No	No	0	8	6
87	R:R:D112	R:R:Y443	10.34	Yes	Yes	1	9	9
88	L:L:?1	R:R:D112	3.87	Yes	Yes	1	0	9
89	R:R:W164	R:R:Y113	14.47	Yes	Yes	1	8	9
90	R:R:I168	R:R:Y113	3.63	Yes	Yes	1	8	9
91	R:R:I187	R:R:Y113	4.84	Yes	Yes	1	7	9
92	R:R:Y113	R:R:Y416	7.94	Yes	Yes	1	9	9
93	R:R:Y113	R:R:Y439	6.95	Yes	Yes	1	9	7
94	L:L:?1	R:R:Y113	10.87	Yes	Yes	1	0	9
95	R:R:F161	R:R:V114	3.93	No	No	0	7	8
96	L:L:?1	R:R:S116	9.64	Yes	No	0	0	8
97	R:R:M121	R:R:N117	4.21	No	Yes	0	8	9
98	R:R:N117	R:R:S160	4.47	Yes	No	0	9	9
99	R:R:N117	R:R:W164	9.04	Yes	Yes	1	9	8
100	L:L:?1	R:R:N117	10.77	Yes	Yes	1	0	9
101	R:R:A118	R:R:W157	9.08	No	Yes	0	9	9
102	R:R:F409	R:R:V120	7.87	Yes	No	1	9	9
103	R:R:V120	R:R:W413	6.13	No	Yes	1	9	9
104	R:R:N122	R:R:W157	4.52	No	Yes	1	9	9
105	R:R:L123	R:R:N449	4.12	No	Yes	1	9	9
106	R:R:L123	R:R:Y453	8.21	No	Yes	1	9	9
107	R:R:F128	R:R:L124	4.87	No	No	0	7	8
108	R:R:I126	R:R:R130	7.52	No	No	1	9	9
109	R:R:I126	R:R:Y453	6.04	No	Yes	1	9	9
110	R:R:M211	R:R:S127	4.6	No	No	0	9	9
111	R:R:L214	R:R:S127	6.01	Yes	No	0	8	9
112	R:R:S127	R:R:Y215	13.99	No	Yes	0	9	9
113	R:R:F128	R:R:L214	10.96	No	Yes	0	7	8
114	R:R:C133	R:R:D129	4.67	No	Yes	2	9	9
115	R:R:D129	R:R:Y140	8.05	Yes	Yes	2	9	9
116	R:R:D129	R:R:R144	10.72	Yes	Yes	2	9	9
117	R:R:R130	R:R:Y215	6.17	No	Yes	0	9	9
118	R:R:R130	R:R:Y453	7.2	No	Yes	1	9	9
119	R:R:F132	R:R:Y131	6.19	No	Yes	0	7	9
120	R:R:T135	R:R:Y131	16.23	No	Yes	0	9	9
121	R:R:L214	R:R:Y131	11.72	Yes	Yes	0	8	9
122	R:R:H217	R:R:Y131	6.53	No	Yes	0	7	9
123	R:R:I218	R:R:Y131	3.63	No	Yes	0	9	9
124	R:R:F132	R:R:Y140	14.44	No	Yes	0	7	9
125	R:R:C133	R:R:Y140	4.03	No	Yes	2	9	9
126	R:R:C133	R:R:R144	5.57	No	Yes	2	9	9
127	R:R:K136	R:R:T139	4.5	No	No	0	7	7
128	R:R:P141	R:R:Y140	4.17	No	Yes	0	7	9
129	R:R:R144	R:R:Y140	11.32	Yes	Yes	2	9	9
130	R:R:K147	R:R:T145	7.51	No	No	0	6	9
131	R:R:L151	R:R:M148	8.48	No	No	0	3	8
132	R:R:A165	R:R:F161	6.93	No	No	0	7	7
133	R:R:L163	R:R:W164	5.69	No	Yes	0	8	8
134	R:R:I168	R:R:W164	3.52	Yes	Yes	1	8	8
135	R:R:T199	R:R:W164	8.49	No	Yes	0	9	8
136	R:R:A203	R:R:W164	3.89	No	Yes	1	9	8
137	L:L:?1	R:R:W164	10.56	Yes	Yes	1	0	8
138	R:R:A167	R:R:F189	4.16	No	Yes	0	8	8
139	R:R:I168	R:R:I187	4.42	Yes	Yes	1	8	7
140	R:R:F189	R:R:I168	3.77	Yes	Yes	1	8	8
141	R:R:F170	R:R:L169	3.65	No	No	0	7	6
142	R:R:Q188	R:R:W171	12.05	No	No	0	8	7
143	R:R:F189	R:R:W171	8.02	Yes	No	0	8	7
144	R:R:F173	R:R:Q172	9.37	No	No	0	6	7
145	R:R:Q172	R:R:R178	5.84	No	Yes	5	7	5
146	R:R:K177	R:R:T179	6.01	No	No	0	3	5
147	R:R:R178	R:R:V180	10.46	Yes	Yes	0	5	5
148	R:R:Q188	R:R:T179	7.09	No	No	0	8	5
149	R:R:P181	R:R:V180	3.53	No	Yes	0	3	5
150	R:R:F186	R:R:V180	11.8	No	Yes	0	4	5
151	R:R:P181	R:R:Q184	12.63	No	No	0	3	5
152	R:R:F186	R:R:Q184	5.86	No	No	0	4	5
153	R:R:F189	R:R:I187	5.02	Yes	Yes	1	8	7
154	R:R:I187	R:R:L190	8.56	Yes	No	0	7	5
155	R:R:F189	R:R:V195	7.87	Yes	No	0	8	8
156	R:R:N192	R:R:P193	4.89	No	No	0	7	5
157	R:R:N192	R:R:V195	5.91	No	No	0	7	8
158	R:R:P193	R:R:T424	5.25	No	No	0	5	7
159	R:R:T196	R:R:T424	4.71	No	No	0	8	7
160	R:R:F197	R:R:L421	9.74	No	No	0	7	7
161	R:R:F197	R:R:F425	4.29	No	No	0	7	6
162	R:R:I201	R:R:Y205	3.63	No	Yes	0	7	8
163	L:L:?1	R:R:A203	5.62	Yes	No	1	0	9
164	R:R:F204	R:R:Y205	11.35	Yes	Yes	0	9	8
165	R:R:F204	R:R:V208	10.49	Yes	No	1	9	8
166	R:R:F204	R:R:F409	5.36	Yes	Yes	1	9	9
167	R:R:F204	R:R:T414	5.19	Yes	No	0	9	7
168	R:R:F204	R:R:N417	18.12	Yes	No	1	9	9
169	R:R:L421	R:R:Y205	5.86	No	Yes	0	7	8
170	R:R:F409	R:R:V208	5.24	Yes	No	1	9	8
171	R:R:H217	R:R:V213	4.15	No	No	0	7	5
172	R:R:I402	R:R:Y215	7.25	No	Yes	0	9	9
173	R:R:I405	R:R:Y215	6.04	Yes	Yes	0	9	9
174	R:R:L406	R:R:Y215	5.86	No	Yes	0	8	9
175	R:R:R223	R:R:R225	7.46	No	No	0	7	8
176	R:R:E395	R:R:R223	15.12	No	No	0	9	7
177	R:R:A393	R:R:R396	4.15	No	No	0	6	7
178	R:R:C452	R:R:I405	4.91	No	Yes	1	9	9
179	R:R:I405	R:R:Y453	4.84	Yes	Yes	1	9	9
180	R:R:L407	R:R:L411	8.3	No	No	0	8	5
181	R:R:F409	R:R:W413	13.03	Yes	Yes	1	9	9
182	R:R:I410	R:R:T414	4.56	No	No	0	8	7
183	R:R:T412	R:R:W413	3.64	No	Yes	1	9	9
184	R:R:N445	R:R:T412	13.16	Yes	No	1	9	9
185	R:R:C442	R:R:W413	7.84	No	Yes	1	9	9
186	R:R:N445	R:R:W413	13.56	Yes	Yes	1	9	9
187	L:L:?1	R:R:W413	16.25	Yes	Yes	1	0	9
188	R:R:N417	R:R:Y416	6.98	No	Yes	1	9	9
189	R:R:V420	R:R:Y416	7.57	No	Yes	0	8	9
190	R:R:C442	R:R:Y416	4.03	No	Yes	1	9	9
191	L:L:?1	R:R:Y416	7.53	Yes	Yes	1	0	9
192	L:L:?1	R:R:N417	3.92	Yes	No	1	0	9
193	R:R:I430	R:R:M419	5.83	Yes	No	0	6	7
194	R:R:N423	R:R:Q427	7.92	No	No	0	5	3
195	R:R:N423	R:R:W435	4.52	No	No	0	5	6
196	R:R:F425	R:R:T424	7.78	No	No	0	6	7
197	R:R:C426	R:R:C429	7.28	No	No	0	7	7
198	R:R:P431	R:R:V434	5.3	No	No	0	6	5
199	R:R:W435	R:R:Y439	5.79	No	Yes	0	6	7
200	R:R:Y439	R:R:Y443	7.94	Yes	Yes	1	7	9
201	L:L:?1	R:R:Y439	7.53	Yes	Yes	1	0	7
202	R:R:W440	R:R:Y443	5.79	Yes	Yes	1	9	9
203	R:R:V444	R:R:W440	4.9	No	Yes	0	6	9
204	L:L:?1	R:R:C442	6.79	Yes	No	1	0	9
205	R:R:N445	R:R:N449	12.26	Yes	Yes	1	9	9
206	R:R:C452	R:R:Y453	4.03	No	Yes	1	9	9
207	R:R:A454	R:R:F460	5.55	No	Yes	0	9	9
208	R:R:F464	R:R:L455	6.09	Yes	No	0	9	8
209	R:R:N457	R:R:T459	5.85	No	No	0	9	8
210	R:R:F460	R:R:N457	7.25	Yes	No	0	9	9
211	R:R:K462	R:R:R465	7.43	No	No	0	6	6
212	R:R:P415	R:R:T414	3.5	No	No	0	9	7
213	R:R:G438	R:R:L441	3.42	No	No	0	7	9
214	R:R:A75	R:R:V53	3.39	No	No	0	9	9
215	R:R:I430	R:R:P431	3.39	Yes	No	0	6	6
216	R:R:L100	R:R:P99	3.28	No	Yes	0	7	5
217	R:R:L124	R:R:P207	3.28	No	No	0	8	9
218	R:R:L206	R:R:P207	3.28	No	No	0	8	9
219	R:R:L441	R:R:P415	3.28	No	No	0	9	9
220	R:R:S160	R:R:V114	3.23	No	No	0	9	8
221	R:R:S222	R:R:V398	3.23	No	No	0	9	9
222	R:R:S224	R:R:V226	3.23	No	No	0	6	6
223	R:R:F170	R:R:F173	3.22	No	No	0	7	6
224	R:R:S219	R:R:T399	3.2	No	No	0	8	9
225	R:R:T447	R:R:V45	3.17	No	No	0	8	5
226	R:R:A202	R:R:L163	3.15	No	No	0	7	8
227	R:R:I437	R:R:S436	3.1	No	No	0	5	6
228	R:R:M86	R:R:S43	3.07	Yes	No	0	9	8
229	R:R:I430	R:R:V422	3.07	Yes	No	0	6	7
230	R:R:I216	R:R:T212	3.04	No	No	0	4	7
231	R:R:M148	R:R:T145	3.01	No	No	0	8	9
232	R:R:L79	R:R:V47	2.98	No	No	0	9	7
233	R:R:L100	R:R:V104	2.98	No	No	0	7	6
234	R:R:L406	R:R:T212	2.95	No	No	0	8	7
235	R:R:I35	R:R:I94	2.94	No	No	0	7	7
236	R:R:Q188	R:R:V180	2.87	No	Yes	0	8	5
237	R:R:E395	R:R:S222	2.87	No	No	0	9	9
238	R:R:I51	R:R:L55	2.85	No	No	0	7	6
239	R:R:I210	R:R:L124	2.85	No	No	0	8	8
240	R:R:I210	R:R:L214	2.85	No	Yes	0	8	8
241	R:R:I448	R:R:N445	2.83	No	Yes	0	7	9
242	R:R:K461	R:R:L455	2.82	No	No	0	9	8
243	R:R:A149	R:R:F70	2.77	No	Yes	0	8	8
244	R:R:A200	R:R:Y205	2.67	No	Yes	0	8	8
245	R:R:A77	R:R:W157	2.59	No	Yes	0	9	9
246	R:R:S436	R:R:Y89	2.54	No	Yes	0	6	8
247	R:R:F72	R:R:I57	2.51	No	No	0	8	9
248	R:R:V175	R:R:W171	2.45	No	No	0	5	7
249	R:R:F403	R:R:L407	2.44	No	No	0	8	8
250	R:R:M419	R:R:W435	2.33	No	No	0	7	6
251	R:R:A149	R:R:G150	1.95	No	No	0	8	5
252	R:R:A165	R:R:P166	1.87	No	No	0	7	9
253	R:R:G40	R:R:S43	1.86	No	No	0	6	8
254	R:R:G49	R:R:V48	1.84	No	No	0	9	5
255	R:R:G101	R:R:V104	1.84	No	No	0	8	6
256	R:R:G176	R:R:V175	1.84	No	No	0	4	5
257	R:R:P431	R:R:T433	1.75	No	No	0	6	4
258	R:R:G49	R:R:L52	1.71	No	No	0	9	8
259	R:R:A83	R:R:V47	1.7	No	No	0	5	7
260	R:R:A221	R:R:V134	1.7	No	No	0	8	9
261	R:R:C456	R:R:T401	1.69	No	No	0	8	9
262	R:R:A221	R:R:T135	1.68	No	No	0	8	9
263	R:R:K136	R:R:P137	1.67	No	No	0	7	9
264	R:R:L138	R:R:P137	1.64	No	No	0	7	9
265	R:R:C429	R:R:I430	1.64	No	Yes	0	7	6
266	R:R:A36	R:R:I94	1.62	No	No	0	6	7
267	R:R:A156	R:R:I125	1.62	No	No	0	9	8
268	R:R:A408	R:R:I448	1.62	No	No	0	8	7
269	R:R:V158	R:R:V162	1.6	No	No	0	5	5
270	R:R:V208	R:R:V209	1.6	No	No	0	8	5
271	R:R:T463	R:R:V59	1.59	Yes	No	0	9	7
272	R:R:T146	R:R:V66	1.59	No	No	0	6	8
273	R:R:T399	R:R:V398	1.59	No	No	0	9	9
274	R:R:A194	R:R:N192	1.56	No	No	0	5	7
275	R:R:A102	R:R:D182	1.54	No	No	0	4	3
276	R:R:I94	R:R:T90	1.52	No	No	0	7	8
277	R:R:I405	R:R:T401	1.52	Yes	No	0	9	9
278	R:R:L42	R:R:S41	1.5	No	No	0	6	5
279	R:R:L42	R:R:V38	1.49	No	No	0	6	5
280	R:R:L44	R:R:V47	1.49	No	No	0	5	7
281	R:R:L111	R:R:V115	1.49	No	No	0	6	8
282	R:R:I216	R:R:L220	1.43	No	No	0	4	4
283	R:R:L159	R:R:M121	1.41	No	No	0	6	8
284	R:R:L107	R:R:L169	1.38	No	No	0	7	6
285	R:R:A392	R:R:R396	1.38	No	No	0	5	7
286	R:R:D182	R:R:N183	1.35	No	No	0	3	4
287	R:R:R394	R:R:V398	1.31	No	No	0	7	9
288	R:R:V418	R:R:Y205	1.26	No	Yes	0	7	8
289	R:R:K397	R:R:R400	1.24	No	No	0	9	7
290	R:R:L220	R:R:R223	1.21	No	No	0	4	7
291	R:R:K136	R:R:Y140	1.19	No	Yes	0	7	9
292	R:R:R143	R:R:Y140	1.03	No	Yes	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T46	6.6525	4	1	8
2	R:R:L63	8.4975	4	3	9
3	R:R:F70	3.774	5	0	8
4	R:R:L74	6.51	4	1	9
5	R:R:D78	7.536	5	1	9
6	R:R:I81	5.962	5	0	9
7	R:R:M86	5.698	5	1	9
8	R:R:Y89	9.212	5	1	8
9	R:R:W98	10.795	6	1	9
10	R:R:P99	5.6725	4	4	5
11	R:R:W108	8.502	5	1	7
12	R:R:D112	7.525	4	1	9
13	R:R:Y113	8.11667	6	1	9
14	R:R:N117	7.1225	4	1	9
15	R:R:D129	6.75	5	2	9
16	R:R:Y131	8.86	5	0	9
17	R:R:Y140	6.31857	7	2	9
18	R:R:R144	9.502	5	2	9
19	R:R:W157	5.5925	4	1	9
20	R:R:W164	7.95143	7	1	8
21	R:R:I168	3.835	4	1	8
22	R:R:R178	7.1975	4	5	5
23	R:R:V180	7.165	4	0	5
24	R:R:I187	5.71	5	1	7
25	R:R:F189	5.768	5	1	8
26	R:R:F204	10.102	5	1	9
27	R:R:Y205	4.954	5	0	8
28	R:R:L214	7.885	4	0	8
29	R:R:Y215	7.862	5	0	9
30	R:R:I405	4.3275	4	1	9
31	R:R:F409	7.875	4	1	9
32	R:R:W413	10.075	6	1	9
33	R:R:Y416	6.81	5	1	9
34	R:R:I430	3.4825	4	0	6
35	R:R:Y439	10.21	5	1	7
36	R:R:W440	7.084	5	1	9
37	R:R:Y443	7.095	6	1	9
38	R:R:N445	10.4525	4	1	9
39	R:R:N449	8.175	4	1	9
40	R:R:Y453	5.64	6	1	9
41	R:R:F460	6.962	5	0	9
42	R:R:T463	4.57	4	3	9
43	R:R:F464	5.3475	4	0	9
44	L:L:?1	8.48636	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M86	R:R:T46	17.3718	6.02	Yes	Yes	1	9	8
2	R:R:N50	R:R:T46	18.9628	4.39	No	Yes	0	9	8
3	R:R:D78	R:R:N50	19.8016	6.73	Yes	No	0	9	9
4	R:R:D78	R:R:L74	15.0784	8.14	Yes	Yes	1	9	9
5	R:R:L123	R:R:L74	16.6628	5.54	No	Yes	1	9	9
6	R:R:L123	R:R:Y453	100	8.21	No	Yes	1	9	9
7	R:R:L71	R:R:Y453	36.6308	3.52	No	Yes	0	8	9
8	R:R:L71	R:R:N68	35.6522	4.12	No	No	0	8	9
9	R:R:F460	R:R:N68	33.5952	7.25	Yes	No	0	9	9
10	R:R:F460	R:R:I57	12.9581	5.02	Yes	No	0	9	9
11	R:R:F72	R:R:I57	11.9728	2.51	No	No	0	8	9
12	R:R:D78	R:R:N449	15.3214	8.08	Yes	Yes	1	9	9
13	R:R:L123	R:R:N449	83.7599	4.12	No	Yes	1	9	9
14	R:R:F460	R:R:L63	17.668	9.74	Yes	Yes	0	9	9
15	R:R:L63	R:R:T463	13.0646	5.9	Yes	Yes	3	9	9
16	R:R:S56	R:R:T463	10.8112	6.4	No	Yes	0	9	9
17	R:R:I126	R:R:Y453	20.0146	6.04	No	Yes	1	9	9
18	R:R:F70	R:R:I126	20.3575	3.77	Yes	No	0	8	9
19	R:R:D129	R:R:F70	15.0318	3.58	Yes	Yes	0	9	8
20	L:L:?1	R:R:D112	12.572	3.87	Yes	Yes	1	0	9
21	L:L:?1	R:R:Y439	13.3575	7.53	Yes	Yes	1	0	7
22	R:R:R178	R:R:V180	24.9376	10.46	Yes	Yes	0	5	5
23	R:R:Q188	R:R:V180	36.3213	2.87	No	Yes	0	8	5
24	R:R:Q188	R:R:W171	43.0716	12.05	No	No	0	8	7
25	R:R:F189	R:R:W171	49.762	8.02	Yes	No	0	8	7
26	R:R:F189	R:R:I168	38.3717	3.77	Yes	Yes	1	8	8
27	R:R:I168	R:R:Y113	21.9153	3.63	Yes	Yes	1	8	9
28	R:R:F189	R:R:I187	24.4283	5.02	Yes	Yes	1	8	7
29	R:R:I187	R:R:Y113	24.0955	4.84	Yes	Yes	1	7	9
30	R:R:Q172	R:R:R178	13.6637	5.84	No	Yes	5	7	5
31	R:R:F173	R:R:Q172	11.3471	9.37	No	No	0	6	7
32	L:L:?1	R:R:W164	19.5353	10.56	Yes	Yes	1	0	8
33	L:L:?1	R:R:W413	68.4852	16.25	Yes	Yes	1	0	9
34	R:R:F409	R:R:W413	10.4117	13.03	Yes	Yes	1	9	9
35	R:R:L214	R:R:S127	31.5614	6.01	Yes	No	0	8	9
36	R:R:S127	R:R:Y215	35.2495	13.99	No	Yes	0	9	9
37	R:R:R130	R:R:Y215	30.483	6.17	No	Yes	0	9	9
38	R:R:R130	R:R:Y453	29.9804	7.2	No	Yes	1	9	9
39	R:R:I405	R:R:Y215	29.8639	6.04	Yes	Yes	0	9	9
40	R:R:I405	R:R:Y453	32.1373	4.84	Yes	Yes	1	9	9
41	R:R:L214	R:R:Y131	14.8554	11.72	Yes	Yes	0	8	9
42	R:R:F189	R:R:V195	10.2719	7.87	Yes	No	0	8	8
43	R:R:F204	R:R:N417	11.3504	18.12	Yes	No	1	9	9
44	R:R:L406	R:R:Y215	23.9889	5.86	No	Yes	0	8	9
45	R:R:L406	R:R:T212	22.1416	2.95	No	No	0	8	7
46	R:R:I216	R:R:T212	20.1378	3.04	No	No	0	4	7
47	R:R:I216	R:R:L220	18.124	1.43	No	No	0	4	4
48	R:R:L220	R:R:R223	16.1036	1.21	No	No	0	4	7
49	R:R:E395	R:R:R223	12.339	15.12	No	No	0	9	7
50	R:R:N445	R:R:W413	75.565	13.56	Yes	Yes	1	9	9
51	R:R:W435	R:R:Y439	11.3604	5.79	No	Yes	0	6	7
52	R:R:E395	R:R:S222	10.2986	2.87	No	No	0	9	9
53	R:R:N445	R:R:N449	75.5384	12.26	Yes	Yes	1	9	9
54	L:L:?1	R:R:Y113	34.7868	10.87	Yes	Yes	1	0	9
55	R:R:I168	R:R:W164	17.7512	3.52	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I81	R:R:S85	6.19	0	Yes	No	9	9	2	2
R:R:I81	R:R:S116	4.64	0	Yes	No	9	8	2	1
R:R:D112	R:R:S85	10.31	1	Yes	No	9	9	1	2
R:R:S85	R:R:Y443	6.36	1	No	Yes	9	9	2	2
R:R:W108	R:R:Y89	5.79	1	Yes	Yes	7	8	2	2
R:R:Y439	R:R:Y89	22.84	1	Yes	Yes	7	8	1	2
R:R:Y443	R:R:Y89	4.96	1	Yes	Yes	9	8	2	2
R:R:D112	R:R:W108	5.58	1	Yes	Yes	9	7	1	2
R:R:D112	R:R:Y443	10.34	1	Yes	Yes	9	9	1	2
L:L:?1	R:R:D112	3.87	1	Yes	Yes	0	9	0	1
R:R:W164	R:R:Y113	14.47	1	Yes	Yes	8	9	1	1
R:R:I168	R:R:Y113	3.63	1	Yes	Yes	8	9	2	1
R:R:I187	R:R:Y113	4.84	1	Yes	Yes	7	9	2	1
R:R:Y113	R:R:Y416	7.94	1	Yes	Yes	9	9	1	1
R:R:Y113	R:R:Y439	6.95	1	Yes	Yes	9	7	1	1
L:L:?1	R:R:Y113	10.87	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:S116	9.64	1	Yes	No	0	8	0	1
R:R:M121	R:R:N117	4.21	0	No	Yes	8	9	2	1
R:R:N117	R:R:S160	4.47	1	Yes	No	9	9	1	2
R:R:N117	R:R:W164	9.04	1	Yes	Yes	9	8	1	1
L:L:?1	R:R:N117	10.77	1	Yes	Yes	0	9	0	1
R:R:F409	R:R:V120	7.87	1	Yes	No	9	9	2	2
R:R:V120	R:R:W413	6.13	1	No	Yes	9	9	2	1
R:R:L163	R:R:W164	5.69	0	No	Yes	8	8	2	1
R:R:I168	R:R:W164	3.52	1	Yes	Yes	8	8	2	1
R:R:T199	R:R:W164	8.49	0	No	Yes	9	8	2	1
R:R:A203	R:R:W164	3.89	1	No	Yes	9	8	1	1
L:L:?1	R:R:W164	10.56	1	Yes	Yes	0	8	0	1
R:R:I168	R:R:I187	4.42	1	Yes	Yes	8	7	2	2
L:L:?1	R:R:A203	5.62	1	Yes	No	0	9	0	1
R:R:F204	R:R:F409	5.36	1	Yes	Yes	9	9	2	2
R:R:F204	R:R:N417	18.12	1	Yes	No	9	9	2	1
R:R:F409	R:R:W413	13.03	1	Yes	Yes	9	9	2	1
R:R:T412	R:R:W413	3.64	1	No	Yes	9	9	2	1
R:R:N445	R:R:T412	13.16	1	Yes	No	9	9	2	2
R:R:C442	R:R:W413	7.84	1	No	Yes	9	9	1	1
R:R:N445	R:R:W413	13.56	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:W413	16.25	1	Yes	Yes	0	9	0	1
R:R:N417	R:R:Y416	6.98	1	No	Yes	9	9	1	1
R:R:V420	R:R:Y416	7.57	0	No	Yes	8	9	2	1
R:R:C442	R:R:Y416	4.03	1	No	Yes	9	9	1	1
L:L:?1	R:R:Y416	7.53	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:N417	3.92	1	Yes	No	0	9	0	1
R:R:W435	R:R:Y439	5.79	0	No	Yes	6	7	2	1
R:R:Y439	R:R:Y443	7.94	1	Yes	Yes	7	9	1	2
L:L:?1	R:R:Y439	7.53	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:C442	6.79	1	Yes	No	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TRK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	253
Number of Links	292
Number of Hubs	44
Number of Links mediated by Hubs	171
Number of Communities	5
Number of Nodes involved in Communities	58
Number of Links involved in Communities	88

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	54162
Length Of Smallest Path	3
Average Path Length	13.0866
Length of Longest Path	30
Minimum Path Strength	1.11
Average Path Strength	7.19243
Maximum Path Strength	16.385
Minimum Path Correlation	0.7
Average Path Correlation	0.921593
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	47.7459
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.0884
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IXO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	IXO
Name	4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium
Synonyms	Iperoxo
Identifier
Formula	C10 H17 N2 O2
Molecular Weight	197.254
SMILES
PubChem	10104167
Formal Charge	1
Total Atoms	31
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>7TRK_nogp_Chain_R M V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G Y W P L G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F I Q F L S N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F K K T F R H L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275	Gi1/β1/γ2	3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275		3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	doi.org/10.1038/nature17188
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	6KP6	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	-	3	2020-03-11	doi.org/10.1107/S2052252520000597
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	9M4Q	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	doi.org/10.1038/nature25758
	9IQS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	Muscarinic toxin 3	-	3.6	2025-07-23	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7TRK_nogp.zip

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