psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T39	R:R:T90	10.99	Yes	No	0	7	8
2	R:R:T39	R:R:W440	10.92	Yes	No	0	7	9
3	R:R:L42	R:R:W440	5.69	No	No	0	6	9
4	R:R:L42	R:R:T447	7.37	No	No	0	6	8
5	R:R:M86	R:R:S43	6.13	Yes	No	0	9	8
6	R:R:N87	R:R:S43	7.45	No	No	0	9	8
7	R:R:M86	R:R:T46	7.53	Yes	No	0	9	8
8	R:R:T447	R:R:T46	12.56	No	No	0	8	8
9	R:R:D78	R:R:N50	6.73	Yes	No	0	9	9
10	R:R:L79	R:R:N50	4.12	Yes	No	0	9	9
11	R:R:N50	R:R:P450	4.89	No	No	0	9	9
12	R:R:F464	R:R:L52	8.53	No	No	0	9	8
13	R:R:F72	R:R:M54	7.46	No	No	0	8	8
14	R:R:L79	R:R:M54	4.24	Yes	No	0	9	8
15	R:R:F460	R:R:S56	5.28	Yes	No	0	9	9
16	R:R:S56	R:R:T463	7.99	No	No	0	9	9
17	R:R:F72	R:R:I57	7.54	No	No	0	8	9
18	R:R:N60	R:R:Q62	5.28	No	No	0	8	6
19	R:R:L63	R:R:N60	9.61	Yes	No	0	9	8
20	R:R:N60	R:R:T463	4.39	No	No	0	8	9
21	R:R:Q64	R:R:R61	8.18	No	No	0	8	8
22	R:R:K462	R:R:Q62	5.42	No	No	0	6	6
23	R:R:L63	R:R:N68	4.12	Yes	No	3	9	9
24	R:R:L63	R:R:T459	7.37	Yes	No	0	9	8
25	R:R:F460	R:R:L63	13.4	Yes	Yes	3	9	9
26	R:R:N68	R:R:T65	7.31	No	No	0	9	8
27	R:R:R144	R:R:V66	9.15	Yes	No	0	9	8
28	R:R:D129	R:R:N67	5.39	Yes	No	2	9	9
29	R:R:N67	R:R:R144	9.64	No	Yes	2	9	9
30	R:R:F460	R:R:N68	4.83	Yes	No	3	9	9
31	R:R:D129	R:R:F70	7.17	Yes	Yes	0	9	8
32	R:R:A149	R:R:F70	4.16	No	Yes	0	8	8
33	R:R:F70	R:R:I153	5.02	Yes	No	0	8	9
34	R:R:N122	R:R:S73	8.94	No	No	1	9	9
35	R:R:I153	R:R:S73	10.84	No	No	0	9	9
36	R:R:S73	R:R:W157	4.94	No	Yes	1	9	9
37	R:R:D78	R:R:L74	4.07	Yes	Yes	1	9	9
38	R:R:L74	R:R:N122	5.49	Yes	No	1	9	9
39	R:R:L123	R:R:L74	5.54	No	Yes	0	9	9
40	R:R:L74	R:R:N449	6.87	Yes	No	1	9	9
41	R:R:D78	R:R:S446	11.78	Yes	No	0	9	9
42	R:R:D78	R:R:N449	8.08	Yes	No	1	9	9
43	R:R:I80	R:R:V115	6.14	No	No	0	8	8
44	R:R:I81	R:R:S85	6.19	Yes	No	1	9	9
45	R:R:I81	R:R:S116	4.64	Yes	No	0	9	8
46	R:R:I81	R:R:Y443	4.84	Yes	Yes	1	9	9
47	R:R:I81	R:R:S446	9.29	Yes	No	0	9	9
48	R:R:G82	R:R:M86	5.24	No	Yes	0	9	9
49	R:R:A83	R:R:F84	4.16	No	No	0	5	6
50	R:R:D112	R:R:S85	10.31	No	No	1	9	9
51	R:R:S85	R:R:Y443	6.36	No	Yes	1	9	9
52	R:R:M86	R:R:W440	6.98	Yes	No	0	9	9
53	R:R:M86	R:R:Y443	8.38	Yes	Yes	0	9	9
54	R:R:L88	R:R:W108	13.67	No	No	0	7	7
55	R:R:I93	R:R:Y89	4.84	No	No	0	7	8
56	R:R:W108	R:R:Y89	4.82	No	No	0	7	8
57	R:R:Y439	R:R:Y89	25.81	No	No	0	7	8
58	R:R:W98	R:R:Y92	5.79	Yes	No	0	9	8
59	R:R:Q184	R:R:Y92	7.89	No	No	0	5	8
60	R:R:I93	R:R:S436	4.64	No	No	0	7	6
61	R:R:K95	R:R:Y97	8.36	No	No	0	5	5
62	R:R:P99	R:R:W98	4.05	No	Yes	0	5	9
63	R:R:L100	R:R:W98	11.39	No	Yes	0	7	9
64	R:R:W108	R:R:W98	6.56	No	Yes	0	7	9
65	R:R:C185	R:R:W98	15.67	No	Yes	0	9	9
66	R:R:L100	R:R:V104	5.96	No	No	0	7	6
67	R:R:A102	R:R:R178	5.53	No	No	0	4	5
68	R:R:C105	R:R:C185	7.28	No	No	0	9	9
69	R:R:D106	R:R:Q172	5.22	No	Yes	4	8	7
70	R:R:D106	R:R:R178	9.53	No	No	4	8	5
71	R:R:I187	R:R:L109	5.71	Yes	No	0	7	8
72	R:R:A110	R:R:L169	4.73	No	No	0	8	6
73	R:R:D112	R:R:Y443	10.34	No	Yes	1	9	9
74	L:L:?1	R:R:D112	7	Yes	No	1	0	9
75	R:R:W164	R:R:Y113	20.26	Yes	Yes	1	8	9
76	R:R:I187	R:R:Y113	8.46	Yes	Yes	0	7	9
77	R:R:Y113	R:R:Y416	6.95	Yes	Yes	1	9	9
78	R:R:Y113	R:R:Y439	7.94	Yes	No	1	9	7
79	L:L:?1	R:R:Y113	19.16	Yes	Yes	1	0	9
80	L:L:?1	R:R:S116	7.75	Yes	No	0	0	8
81	R:R:N117	R:R:S160	4.47	No	No	0	9	9
82	R:R:L163	R:R:N117	4.12	No	No	1	8	9
83	R:R:N117	R:R:W164	6.78	No	Yes	1	9	8
84	R:R:A118	R:R:W157	7.78	No	Yes	0	9	9
85	R:R:F409	R:R:V120	5.24	Yes	No	1	9	9
86	R:R:V120	R:R:W413	4.9	No	Yes	1	9	9
87	R:R:N122	R:R:W157	4.52	No	Yes	1	9	9
88	R:R:L123	R:R:Y453	7.03	No	Yes	0	9	9
89	R:R:F128	R:R:L124	4.87	No	No	0	7	8
90	R:R:I126	R:R:R130	6.26	No	No	0	9	9
91	R:R:L214	R:R:S127	6.01	Yes	No	0	8	9
92	R:R:S127	R:R:Y215	7.63	No	Yes	0	9	9
93	R:R:F128	R:R:L214	7.31	No	Yes	0	7	8
94	R:R:D129	R:R:Y140	8.05	Yes	Yes	2	9	9
95	R:R:D129	R:R:R144	14.29	Yes	Yes	2	9	9
96	R:R:R130	R:R:Y215	6.17	No	Yes	0	9	9
97	R:R:R130	R:R:Y453	7.2	No	Yes	0	9	9
98	R:R:F132	R:R:Y131	5.16	No	Yes	0	7	9
99	R:R:T135	R:R:Y131	12.48	No	Yes	0	9	9
100	R:R:L214	R:R:Y131	12.89	Yes	Yes	0	8	9
101	R:R:H217	R:R:Y131	5.44	No	Yes	0	7	9
102	R:R:F132	R:R:Y140	10.32	No	Yes	0	7	9
103	R:R:C133	R:R:Y140	4.03	No	Yes	0	9	9
104	R:R:R143	R:R:T139	5.17	No	No	0	6	7
105	R:R:P141	R:R:Y140	4.17	No	Yes	0	7	9
106	R:R:R144	R:R:Y140	11.32	Yes	Yes	2	9	9
107	R:R:K147	R:R:T145	6.01	No	No	0	6	9
108	R:R:A165	R:R:F161	6.93	No	No	0	7	7
109	R:R:L163	R:R:W164	5.69	No	Yes	1	8	8
110	R:R:I168	R:R:W164	4.7	No	Yes	0	8	8
111	R:R:T199	R:R:W164	6.06	No	Yes	0	9	8
112	L:L:?1	R:R:W164	11.75	Yes	Yes	1	0	8
113	R:R:V175	R:R:W171	6.13	No	No	0	5	7
114	R:R:Q188	R:R:W171	5.48	Yes	No	0	8	7
115	R:R:F189	R:R:W171	13.03	Yes	No	0	8	7
116	R:R:F173	R:R:Q172	14.05	No	Yes	0	6	7
117	R:R:Q172	R:R:R178	8.18	Yes	No	4	7	5
118	R:R:Q172	R:R:Q188	5.12	Yes	Yes	0	7	8
119	R:R:Q188	R:R:T179	8.5	Yes	No	0	8	5
120	R:R:F186	R:R:V180	11.8	No	No	0	4	5
121	R:R:Q188	R:R:V180	7.16	Yes	No	0	8	5
122	R:R:F189	R:R:I187	7.54	Yes	Yes	0	8	7
123	R:R:I187	R:R:L190	7.14	Yes	No	0	7	5
124	R:R:F189	R:R:V195	6.55	Yes	No	0	8	8
125	R:R:N192	R:R:P193	4.89	No	No	0	7	5
126	R:R:N192	R:R:V195	5.91	No	No	0	7	8
127	R:R:P193	R:R:T424	5.25	No	No	0	5	7
128	R:R:F197	R:R:L421	4.87	No	No	0	7	7
129	R:R:I201	R:R:Y205	7.25	No	Yes	0	7	8
130	L:L:?1	R:R:A203	4.07	Yes	No	0	0	9
131	R:R:F204	R:R:Y205	10.32	Yes	Yes	1	9	8
132	R:R:F204	R:R:F409	4.29	Yes	Yes	1	9	9
133	R:R:F204	R:R:W413	7.02	Yes	Yes	1	9	9
134	R:R:F204	R:R:T414	5.19	Yes	No	0	9	7
135	R:R:F204	R:R:N417	20.54	Yes	No	1	9	9
136	R:R:N417	R:R:Y205	5.81	No	Yes	1	9	8
137	R:R:L421	R:R:Y205	7.03	No	Yes	0	7	8
138	R:R:F409	R:R:V208	5.24	Yes	No	0	9	8
139	R:R:I218	R:R:Y215	4.84	No	Yes	0	9	9
140	R:R:I402	R:R:Y215	8.46	No	Yes	0	9	9
141	R:R:I405	R:R:Y215	6.04	No	Yes	0	9	9
142	R:R:L406	R:R:Y215	4.69	No	Yes	0	8	9
143	R:R:S222	R:R:V398	8.08	No	No	0	9	9
144	R:R:R223	R:R:R225	6.4	No	No	0	7	8
145	R:R:E395	R:R:R223	18.61	No	No	0	9	7
146	R:R:K397	R:R:T401	6.01	No	No	0	9	9
147	R:R:F403	R:R:T399	7.78	No	No	0	8	9
148	R:R:I405	R:R:Y453	9.67	No	Yes	0	9	9
149	R:R:F409	R:R:W413	9.02	Yes	Yes	1	9	9
150	R:R:T412	R:R:W413	4.85	Yes	Yes	1	9	9
151	R:R:N445	R:R:T412	8.77	No	Yes	1	9	9
152	R:R:N445	R:R:W413	7.91	No	Yes	1	9	9
153	L:L:?1	R:R:W413	12.73	Yes	Yes	1	0	9
154	R:R:P415	R:R:T414	5.25	No	No	0	9	7
155	R:R:L441	R:R:P415	4.93	No	No	0	9	9
156	R:R:N417	R:R:Y416	4.65	No	Yes	1	9	9
157	R:R:V420	R:R:Y416	6.31	No	Yes	0	8	9
158	R:R:C442	R:R:Y416	4.03	No	Yes	1	9	9
159	L:L:?1	R:R:Y416	12.1	Yes	Yes	1	0	9
160	R:R:I430	R:R:M419	4.37	Yes	No	0	6	7
161	R:R:N423	R:R:Q427	17.17	No	No	0	5	3
162	R:R:N423	R:R:W435	9.04	No	No	0	5	6
163	R:R:C426	R:R:C429	7.28	No	No	0	7	7
164	R:R:I430	R:R:W435	4.7	Yes	No	0	6	6
165	R:R:P431	R:R:V434	10.6	No	No	0	6	5
166	L:L:?1	R:R:Y439	16.13	Yes	No	1	0	7
167	L:L:?1	R:R:C442	9.55	Yes	No	1	0	9
168	L:L:?1	R:R:Y443	4.03	Yes	Yes	1	0	9
169	R:R:N445	R:R:N449	6.81	No	No	1	9	9
170	R:R:C452	R:R:Y453	4.03	No	Yes	0	9	9
171	R:R:A454	R:R:F460	5.55	No	Yes	0	9	9
172	R:R:F464	R:R:L455	8.53	No	No	0	9	8
173	R:R:N457	R:R:T459	7.31	No	No	0	9	8
174	R:R:F460	R:R:N457	6.04	Yes	No	0	9	9
175	R:R:K462	R:R:T459	6.01	No	No	0	6	8
176	R:R:F464	R:R:S56	3.96	No	No	0	9	9
177	R:R:F161	R:R:V114	3.93	No	No	0	7	8
178	R:R:F70	R:R:M152	3.73	Yes	No	0	8	8
179	R:R:V420	R:R:W435	3.68	No	No	0	8	6
180	R:R:P450	R:R:V53	3.53	No	No	0	9	9
181	R:R:P207	R:R:V120	3.53	No	No	0	9	9
182	R:R:P181	R:R:V180	3.53	No	No	0	3	5
183	R:R:N183	R:R:Y97	3.49	No	No	0	4	5
184	R:R:A75	R:R:V53	3.39	No	No	0	9	9
185	R:R:I430	R:R:P431	3.39	Yes	No	0	6	6
186	R:R:C456	R:R:T401	3.38	No	No	0	8	9
187	R:R:L206	R:R:P207	3.28	No	No	0	8	9
188	R:R:C429	R:R:I430	3.27	No	Yes	0	7	6
189	R:R:A156	R:R:I125	3.25	No	No	0	9	8
190	R:R:C76	R:R:M54	3.24	No	No	0	8	8
191	R:R:S224	R:R:V226	3.23	No	No	0	6	6
192	R:R:F197	R:R:F425	3.22	No	No	0	7	6
193	R:R:S436	R:R:T433	3.2	No	No	0	6	4
194	R:R:T447	R:R:V45	3.17	No	No	0	8	5
195	R:R:T412	R:R:V444	3.17	Yes	No	0	9	6
196	R:R:I437	R:R:S436	3.1	No	No	0	5	6
197	R:R:I81	R:R:V115	3.07	Yes	No	0	9	8
198	R:R:M211	R:R:S127	3.07	No	No	0	9	9
199	R:R:I410	R:R:V208	3.07	No	No	0	8	8
200	R:R:I402	R:R:V398	3.07	No	No	0	9	9
201	R:R:I430	R:R:V422	3.07	Yes	No	0	6	7
202	R:R:K95	R:R:V91	3.04	No	No	0	5	8
203	R:R:K177	R:R:V175	3.04	No	No	0	3	5
204	R:R:L74	R:R:S119	3	Yes	No	0	9	9
205	R:R:L79	R:R:V47	2.98	Yes	No	0	9	7
206	R:R:L190	R:R:T196	2.95	No	No	0	5	8
207	R:R:N67	R:R:T65	2.92	No	No	0	9	8
208	R:R:M148	R:R:M152	2.89	No	No	0	8	8
209	R:R:F170	R:R:P166	2.89	No	No	0	7	9
210	R:R:D432	R:R:T433	2.89	No	No	0	3	4
211	R:R:I51	R:R:L79	2.85	No	Yes	0	7	9
212	R:R:I210	R:R:L124	2.85	No	No	0	8	8
213	R:R:I210	R:R:L214	2.85	No	Yes	0	8	8
214	R:R:L124	R:R:M121	2.83	No	No	0	8	8
215	R:R:L159	R:R:M121	2.83	No	No	0	6	8
216	R:R:G101	R:R:W98	2.81	No	Yes	0	8	9
217	R:R:P99	R:R:Y97	2.78	No	No	0	5	5
218	R:R:A167	R:R:F189	2.77	No	Yes	0	8	8
219	R:R:A200	R:R:Y205	2.67	No	Yes	0	8	8
220	R:R:A77	R:R:W157	2.59	No	Yes	0	9	9
221	R:R:F70	R:R:I125	2.51	Yes	No	0	8	8
222	R:R:T146	R:R:Y69	2.5	No	No	0	6	7
223	R:R:F460	R:R:L71	2.44	Yes	No	0	9	8
224	R:R:G49	R:R:P450	2.03	No	No	0	9	9
225	R:R:A165	R:R:P166	1.87	No	No	0	7	9
226	R:R:G40	R:R:T39	1.82	No	Yes	0	6	7
227	R:R:G150	R:R:I153	1.76	No	No	0	5	9
228	R:R:G438	R:R:M419	1.75	No	No	0	7	7
229	R:R:A83	R:R:V47	1.7	No	No	0	5	7
230	R:R:A221	R:R:V134	1.7	No	No	0	8	9
231	R:R:K136	R:R:P137	1.67	No	No	0	7	9
232	R:R:L138	R:R:P137	1.64	No	No	0	7	9
233	R:R:A36	R:R:I94	1.62	No	No	0	6	7
234	R:R:A110	R:R:I168	1.62	No	No	0	8	8
235	R:R:S160	R:R:V114	1.62	No	No	0	9	8
236	R:R:A408	R:R:I448	1.62	No	No	0	8	7
237	R:R:V47	R:R:V48	1.6	No	No	0	7	5
238	R:R:V103	R:R:V104	1.6	No	No	0	5	6
239	R:R:S219	R:R:T399	1.6	No	No	0	8	9
240	R:R:T37	R:R:V33	1.59	No	No	0	5	6
241	R:R:T146	R:R:V66	1.59	No	No	0	6	8
242	R:R:A451	R:R:L455	1.58	No	No	0	7	8
243	R:R:A194	R:R:N192	1.56	No	No	0	5	7
244	R:R:I402	R:R:S219	1.55	No	No	0	9	8
245	R:R:I94	R:R:V91	1.54	No	No	0	7	8
246	R:R:I218	R:R:V134	1.54	No	No	0	9	9
247	R:R:I35	R:R:T39	1.52	No	Yes	0	7	7
248	R:R:I216	R:R:T212	1.52	No	No	0	4	7
249	R:R:I448	R:R:T412	1.52	No	Yes	0	7	9
250	R:R:M148	R:R:T145	1.51	No	No	0	8	9
251	R:R:F197	R:R:G198	1.51	No	No	0	7	7
252	R:R:K136	R:R:T135	1.5	No	No	0	7	9
253	R:R:L44	R:R:V48	1.49	No	No	0	5	5
254	R:R:L111	R:R:V115	1.49	No	No	0	6	8
255	R:R:L138	R:R:T139	1.47	No	No	0	7	7
256	R:R:E395	R:R:S222	1.44	No	No	0	9	9
257	R:R:K461	R:R:L455	1.41	No	No	0	9	8
258	R:R:L107	R:R:L169	1.38	No	No	0	7	6
259	R:R:A142	R:R:R143	1.38	No	No	0	6	6
260	R:R:H217	R:R:V213	1.38	No	No	0	7	5
261	R:R:H217	R:R:I216	1.33	No	No	0	7	4
262	R:R:R394	R:R:S224	1.32	No	No	0	7	6
263	R:R:V418	R:R:Y205	1.26	No	Yes	0	7	8
264	R:R:K462	R:R:R465	1.24	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T39	6.3125	4	0	7
2	R:R:L63	8.625	4	3	9
3	R:R:F70	4.518	5	0	8
4	R:R:L74	4.994	5	1	9
5	R:R:D78	7.665	4	1	9
6	R:R:L79	3.5475	4	0	9
7	R:R:I81	5.606	5	1	9
8	R:R:M86	6.852	5	0	9
9	R:R:W98	7.71167	6	0	9
10	R:R:Y113	12.554	5	1	9
11	R:R:D129	8.725	4	2	9
12	R:R:Y131	8.9925	4	0	9
13	R:R:Y140	7.578	5	2	9
14	R:R:R144	11.1	4	2	9
15	R:R:W157	4.9575	4	1	9
16	R:R:W164	9.20667	6	1	8
17	R:R:Q172	8.1425	4	4	7
18	R:R:I187	7.2125	4	0	7
19	R:R:Q188	6.565	4	0	8
20	R:R:F189	7.4725	4	0	8
21	R:R:F204	9.472	5	1	9
22	R:R:Y205	5.72333	6	1	8
23	R:R:L214	7.265	4	0	8
24	R:R:Y215	6.305	6	0	9
25	R:R:F409	5.9475	4	1	9
26	R:R:T412	4.5775	4	1	9
27	R:R:W413	7.73833	6	1	9
28	R:R:Y416	6.808	5	1	9
29	R:R:I430	3.76	5	0	6
30	R:R:Y443	6.79	5	1	9
31	R:R:Y453	6.9825	4	0	9
32	R:R:F460	6.25667	6	3	9
33	L:L:?1	10.427	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M86	R:R:W440	10.6222	6.98	Yes	No	0	9	9
2	R:R:D78	R:R:S446	40.0079	11.78	Yes	No	0	9	9
3	R:R:I81	R:R:S446	40.4632	9.29	Yes	No	0	9	9
4	R:R:I81	R:R:Y443	27.4857	4.84	Yes	Yes	1	9	9
5	R:R:M86	R:R:Y443	22.8541	8.38	Yes	Yes	0	9	9
6	R:R:D78	R:R:N50	44.0127	6.73	Yes	No	0	9	9
7	R:R:L79	R:R:N50	30.6195	4.12	Yes	No	0	9	9
8	R:R:N50	R:R:P450	11.3149	4.89	No	No	0	9	9
9	R:R:F460	R:R:S56	12.6014	5.28	Yes	No	0	9	9
10	R:R:F460	R:R:N68	18.823	4.83	Yes	No	3	9	9
11	R:R:N68	R:R:T65	32.5856	7.31	No	No	0	9	8
12	R:R:N67	R:R:T65	34.1822	2.92	No	No	0	9	8
13	R:R:D129	R:R:N67	29.1153	5.39	Yes	No	2	9	9
14	R:R:D129	R:R:F70	35.3038	7.17	Yes	Yes	0	9	8
15	R:R:F70	R:R:I153	40.5159	5.02	Yes	No	0	8	9
16	R:R:I153	R:R:S73	42.1917	10.84	No	No	0	9	9
17	R:R:N122	R:R:S73	41.8223	8.94	No	No	1	9	9
18	R:R:L74	R:R:N122	46.8826	5.49	Yes	No	1	9	9
19	R:R:D78	R:R:L74	33.4037	4.07	Yes	Yes	1	9	9
20	R:R:L79	R:R:M54	11.3149	4.24	Yes	No	0	9	8
21	R:R:L63	R:R:N68	12.1396	4.12	Yes	No	3	9	9
22	R:R:L123	R:R:L74	80.3259	5.54	No	Yes	0	9	9
23	R:R:D78	R:R:N449	12.2056	8.08	Yes	No	1	9	9
24	R:R:N445	R:R:N449	100	6.81	No	No	1	9	9
25	R:R:N445	R:R:W413	95.9886	7.91	No	Yes	1	9	9
26	L:L:?1	R:R:W413	90.6116	12.73	Yes	Yes	1	0	9
27	L:L:?1	R:R:Y443	23.9229	4.03	Yes	Yes	1	0	9
28	R:R:I81	R:R:S116	13.7494	4.64	Yes	No	0	9	8
29	L:L:?1	R:R:S116	13.5119	7.75	Yes	No	0	0	8
30	R:R:L79	R:R:V47	14.1123	2.98	Yes	No	0	9	7
31	R:R:W108	R:R:Y89	39.5329	4.82	No	No	0	7	8
32	R:R:Y439	R:R:Y89	51.7913	25.81	No	No	0	7	8
33	L:L:?1	R:R:Y439	43.9929	16.13	Yes	No	1	0	7
34	R:R:I93	R:R:Y89	11.5458	4.84	No	No	0	7	8
35	R:R:W108	R:R:W98	35.4952	6.56	No	Yes	0	7	9
36	R:R:P99	R:R:Y97	13.6637	2.78	No	No	0	5	5
37	R:R:P99	R:R:W98	15.9266	4.05	No	Yes	0	5	9
38	R:R:Q188	R:R:W171	19.9314	5.48	Yes	No	0	8	7
39	R:R:F189	R:R:W171	25.7505	13.03	Yes	No	0	8	7
40	R:R:F189	R:R:I187	38.5498	7.54	Yes	Yes	0	8	7
41	R:R:I187	R:R:Y113	45.4575	8.46	Yes	Yes	0	7	9
42	L:L:?1	R:R:Y113	36.6761	19.16	Yes	Yes	1	0	9
43	L:L:?1	R:R:W164	25.3744	11.75	Yes	Yes	1	0	8
44	L:L:?1	R:R:Y416	26.2651	12.1	Yes	Yes	1	0	9
45	R:R:N117	R:R:W164	16.5732	6.78	No	Yes	1	9	8
46	R:R:N117	R:R:S160	14.2838	4.47	No	No	0	9	9
47	R:R:F128	R:R:L214	10.7409	7.31	No	Yes	0	7	8
48	R:R:L214	R:R:S127	52.3982	6.01	Yes	No	0	8	9
49	R:R:S127	R:R:Y215	55.6838	7.63	No	Yes	0	9	9
50	R:R:R130	R:R:Y215	38.5696	6.17	No	Yes	0	9	9
51	R:R:R130	R:R:Y453	39.5461	7.2	No	Yes	0	9	9
52	R:R:L123	R:R:Y453	79.4946	7.03	No	Yes	0	9	9
53	R:R:I405	R:R:Y215	38.022	6.04	No	Yes	0	9	9
54	R:R:I405	R:R:Y453	38.5828	9.67	No	Yes	0	9	9
55	R:R:I210	R:R:L214	10.7937	2.85	No	Yes	0	8	8
56	R:R:D129	R:R:Y140	13.4063	8.05	Yes	Yes	2	9	9
57	R:R:F132	R:R:Y140	17.3121	10.32	No	Yes	0	7	9
58	R:R:L214	R:R:Y131	37.2633	12.89	Yes	Yes	0	8	9
59	R:R:T135	R:R:Y131	18.6053	12.48	No	Yes	0	9	9
60	R:R:H217	R:R:Y131	10.7079	5.44	No	Yes	0	7	9
61	R:R:L138	R:R:P137	10.7079	1.64	No	No	0	7	9
62	R:R:K136	R:R:P137	13.3536	1.67	No	No	0	7	9
63	R:R:K136	R:R:T135	15.986	1.5	No	No	0	7	9
64	R:R:S160	R:R:V114	11.9351	1.62	No	No	0	9	8
65	R:R:F189	R:R:V195	10.0877	6.55	Yes	No	0	8	8
66	R:R:L421	R:R:Y205	10.0284	7.03	No	Yes	0	7	8
67	R:R:F204	R:R:Y205	12.0538	10.32	Yes	Yes	1	9	8
68	R:R:F204	R:R:W413	19.1397	7.02	Yes	Yes	1	9	9
69	R:R:N417	R:R:Y416	10.0086	4.65	No	Yes	1	9	9
70	R:R:I402	R:R:Y215	22.9729	8.46	No	Yes	0	9	9
71	R:R:S222	R:R:V398	10.1867	8.08	No	No	0	9	9
72	R:R:I402	R:R:V398	12.5355	3.07	No	No	0	9	9
73	R:R:V420	R:R:Y416	26.8853	6.31	No	Yes	0	8	9
74	R:R:I430	R:R:W435	18.2556	4.7	Yes	No	0	6	6
75	R:R:V420	R:R:W435	24.6949	3.68	No	No	0	8	6
76	R:R:L124	R:R:M121	10.8267	2.83	No	No	0	8	8
77	R:R:L74	R:R:N449	88.0781	6.87	Yes	No	1	9	9
78	R:R:F132	R:R:Y131	16.2037	5.16	No	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I81	R:R:S85	6.19	1	Yes	No	9	9	2	2
R:R:I81	R:R:S116	4.64	1	Yes	No	9	8	2	1
R:R:I81	R:R:Y443	4.84	1	Yes	Yes	9	9	2	1
R:R:D112	R:R:S85	10.31	1	No	No	9	9	1	2
R:R:S85	R:R:Y443	6.36	1	No	Yes	9	9	2	1
R:R:M86	R:R:Y443	8.38	0	Yes	Yes	9	9	2	1
R:R:Y439	R:R:Y89	25.81	1	No	No	7	8	1	2
R:R:D112	R:R:Y443	10.34	1	No	Yes	9	9	1	1
L:L:?1	R:R:D112	7	1	Yes	No	0	9	0	1
R:R:W164	R:R:Y113	20.26	1	Yes	Yes	8	9	1	1
R:R:I187	R:R:Y113	8.46	0	Yes	Yes	7	9	2	1
R:R:Y113	R:R:Y416	6.95	1	Yes	Yes	9	9	1	1
R:R:Y113	R:R:Y439	7.94	1	Yes	No	9	7	1	1
L:L:?1	R:R:Y113	19.16	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:S116	7.75	1	Yes	No	0	8	0	1
R:R:L163	R:R:N117	4.12	1	No	No	8	9	2	2
R:R:N117	R:R:W164	6.78	1	No	Yes	9	8	2	1
R:R:F409	R:R:V120	5.24	1	Yes	No	9	9	2	2
R:R:V120	R:R:W413	4.9	1	No	Yes	9	9	2	1
R:R:L163	R:R:W164	5.69	1	No	Yes	8	8	2	1
R:R:I168	R:R:W164	4.7	0	No	Yes	8	8	2	1
R:R:T199	R:R:W164	6.06	0	No	Yes	9	8	2	1
L:L:?1	R:R:W164	11.75	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:A203	4.07	1	Yes	No	0	9	0	1
R:R:F204	R:R:F409	4.29	1	Yes	Yes	9	9	2	2
R:R:F204	R:R:W413	7.02	1	Yes	Yes	9	9	2	1
R:R:F204	R:R:N417	20.54	1	Yes	No	9	9	2	2
R:R:F409	R:R:W413	9.02	1	Yes	Yes	9	9	2	1
R:R:T412	R:R:W413	4.85	1	Yes	Yes	9	9	2	1
R:R:N445	R:R:T412	8.77	1	No	Yes	9	9	2	2
R:R:N445	R:R:W413	7.91	1	No	Yes	9	9	2	1
L:L:?1	R:R:W413	12.73	1	Yes	Yes	0	9	0	1
R:R:N417	R:R:Y416	4.65	1	No	Yes	9	9	2	1
R:R:V420	R:R:Y416	6.31	0	No	Yes	8	9	2	1
R:R:C442	R:R:Y416	4.03	1	No	Yes	9	9	1	1
L:L:?1	R:R:Y416	12.1	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y439	16.13	1	Yes	No	0	7	0	1
L:L:?1	R:R:C442	9.55	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y443	4.03	1	Yes	Yes	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TRS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.02
Number of Linked Nodes	241
Number of Links	264
Number of Hubs	33
Number of Links mediated by Hubs	136
Number of Communities	4
Number of Nodes involved in Communities	36
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	39011
Length Of Smallest Path	3
Average Path Length	12.5677
Length of Longest Path	29
Minimum Path Strength	1.355
Average Path Strength	7.35801
Maximum Path Strength	20.97
Minimum Path Correlation	0.7
Average Path Correlation	0.924145
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	53.4017
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.606
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACH
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ACH
Name	Acetylcholine
Synonyms	Acetylcholine O-Acetylcholine ACh Acetylcholine chloride Choline acetate
Identifier
Formula	C7 H16 N O2
Molecular Weight	146.207
SMILES
PubChem	187
Formal Charge	1
Total Atoms	26
Total Chiral Atoms	0
Total Bonds	25
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>7TRS_nogp_Chain_R M V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G Y W P L G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F I Q F L S N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F K K T F R H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	10.1038/s41467-023-41199-5
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	10.2139/ssrn.4034884
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	10.2139/ssrn.4034884
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	10.2139/ssrn.4034884
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	10.2139/ssrn.4034884
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	10.1038/s41586-022-05489-0
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	10.1038/s41594-022-00796-6
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	PubChem 9864275	-	Gi1/β1/γ2	3.6	2022-05-11	10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	PubChem 9864275	-		3.6	2022-05-11	10.1038/s41467-022-30595-y
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	10.1038/s41467-022-30595-y
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	PubChem 57664406	Gi1/β1/γ2	3.4	2022-05-11	10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	PubChem 57664406		3.4	2022-05-11	10.1038/s41467-022-30595-y
	6KP6	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	-	3	2020-03-11	10.1107/S2052252520000597
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	10.1038/nature25758
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	10.1038/s41598-017-18570-w
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	10.1038/s41467-017-00630-4
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	10.1038/nature17188

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