psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D112	8.21	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y113	22.06	Yes	Yes	1	0	9
3	L:L:?1	R:R:S116	9.08	Yes	No	0	0	8
4	L:L:?1	R:R:W164	12.25	Yes	Yes	1	0	8
5	L:L:?1	R:R:W413	13.01	Yes	Yes	0	0	9
6	L:L:?1	R:R:Y416	14.97	Yes	Yes	1	0	9
7	L:L:?1	R:R:N417	5.54	Yes	No	0	0	9
8	L:L:?1	R:R:V420	5.01	Yes	No	1	0	8
9	L:L:?1	R:R:Y439	7.09	Yes	Yes	1	0	7
10	L:L:?1	R:R:C442	5.33	Yes	No	0	0	9
11	R:R:T39	R:R:T90	12.56	Yes	No	1	7	8
12	R:R:T39	R:R:W440	7.28	Yes	Yes	1	7	9
13	R:R:L42	R:R:T447	5.9	No	No	0	6	8
14	R:R:M86	R:R:S43	4.6	Yes	No	0	9	8
15	R:R:N87	R:R:S43	5.96	No	No	0	9	8
16	R:R:M86	R:R:T46	7.53	Yes	No	0	9	8
17	R:R:T447	R:R:T46	12.56	No	No	0	8	8
18	R:R:D78	R:R:N50	8.08	Yes	No	0	9	9
19	R:R:N50	R:R:P450	9.77	No	No	0	9	9
20	R:R:F464	R:R:L52	7.31	Yes	No	0	9	8
21	R:R:F72	R:R:M54	11.2	Yes	No	0	8	8
22	R:R:S56	R:R:T463	6.4	No	No	0	9	9
23	R:R:F72	R:R:I57	8.79	Yes	No	0	8	9
24	R:R:N60	R:R:Q62	6.6	No	No	0	8	6
25	R:R:L63	R:R:N60	6.87	No	No	0	9	8
26	R:R:N60	R:R:T463	8.77	No	No	0	8	9
27	R:R:Q64	R:R:R61	14.02	No	No	0	8	8
28	R:R:L63	R:R:T459	5.9	No	No	0	9	8
29	R:R:F460	R:R:L63	17.05	Yes	No	0	9	9
30	R:R:N67	R:R:T65	5.85	No	No	0	9	8
31	R:R:N68	R:R:T65	8.77	No	No	0	9	8
32	R:R:R144	R:R:V66	10.46	Yes	No	0	9	8
33	R:R:D129	R:R:N67	5.39	Yes	No	2	9	9
34	R:R:N67	R:R:R144	10.85	No	Yes	2	9	9
35	R:R:F70	R:R:I125	5.02	Yes	No	0	8	8
36	R:R:D129	R:R:F70	4.78	Yes	Yes	0	9	8
37	R:R:F70	R:R:I153	5.02	Yes	No	0	8	9
38	R:R:N122	R:R:S73	8.94	No	No	0	9	9
39	R:R:I153	R:R:S73	6.19	No	No	0	9	9
40	R:R:S73	R:R:W157	6.18	No	Yes	0	9	9
41	R:R:D78	R:R:L74	8.14	Yes	No	3	9	9
42	R:R:L123	R:R:L74	5.54	No	No	0	9	9
43	R:R:L74	R:R:N449	8.24	No	No	3	9	9
44	R:R:D78	R:R:S446	10.31	Yes	No	0	9	9
45	R:R:D78	R:R:N449	8.08	Yes	No	3	9	9
46	R:R:I80	R:R:V115	9.22	No	No	0	8	8
47	R:R:I81	R:R:S116	4.64	No	No	0	9	8
48	R:R:I81	R:R:S446	9.29	No	No	0	9	9
49	R:R:G82	R:R:M86	5.24	No	Yes	0	9	9
50	R:R:D112	R:R:S85	8.83	Yes	No	0	9	9
51	R:R:M86	R:R:W440	4.65	Yes	Yes	1	9	9
52	R:R:M86	R:R:Y443	8.38	Yes	Yes	1	9	9
53	R:R:L88	R:R:W108	10.25	No	No	0	7	7
54	R:R:I93	R:R:Y89	7.25	No	Yes	0	7	8
55	R:R:Y439	R:R:Y89	15.89	Yes	Yes	1	7	8
56	R:R:W440	R:R:Y89	11.58	Yes	Yes	1	9	8
57	R:R:Y443	R:R:Y89	7.94	Yes	Yes	1	9	8
58	R:R:Y89	W:W:?1	6.3	Yes	Yes	0	8	0
59	R:R:W98	R:R:Y92	8.68	Yes	No	0	9	8
60	R:R:Q184	R:R:Y92	6.76	No	No	0	5	8
61	R:R:K95	R:R:P99	6.69	No	No	0	5	5
62	R:R:N183	R:R:Y97	11.63	No	No	0	4	5
63	R:R:L100	R:R:W98	6.83	No	Yes	0	7	9
64	R:R:C105	R:R:W98	5.22	No	Yes	4	9	9
65	R:R:C185	R:R:W98	9.14	No	Yes	4	9	9
66	R:R:C105	R:R:C185	7.28	No	No	4	9	9
67	R:R:D106	R:R:R178	8.34	No	Yes	0	8	5
68	R:R:L109	R:R:W108	5.69	No	No	0	8	7
69	R:R:C185	R:R:L109	4.76	No	No	0	9	8
70	R:R:I187	R:R:L109	5.71	Yes	No	0	7	8
71	R:R:A110	R:R:L169	4.73	No	No	0	8	6
72	R:R:D112	R:R:Y113	5.75	Yes	Yes	1	9	9
73	R:R:D112	R:R:Y443	5.75	Yes	Yes	1	9	9
74	R:R:W164	R:R:Y113	15.43	Yes	Yes	1	8	9
75	R:R:I187	R:R:Y113	10.88	Yes	Yes	0	7	9
76	R:R:Y113	R:R:Y416	4.96	Yes	Yes	1	9	9
77	R:R:M121	R:R:N117	5.61	No	No	0	8	9
78	R:R:N117	R:R:W164	10.17	No	Yes	0	9	8
79	R:R:A118	R:R:W157	9.08	No	Yes	0	9	9
80	R:R:V120	R:R:W413	6.13	No	Yes	0	9	9
81	R:R:L123	R:R:Y453	9.38	No	Yes	0	9	9
82	R:R:F128	R:R:L124	4.87	No	No	0	7	8
83	R:R:L124	R:R:P207	4.93	No	No	0	8	9
84	R:R:I126	R:R:R130	6.26	No	No	5	9	9
85	R:R:I126	R:R:Y453	4.84	No	Yes	5	9	9
86	R:R:M211	R:R:S127	4.6	No	No	0	9	9
87	R:R:L214	R:R:S127	6.01	Yes	No	0	8	9
88	R:R:S127	R:R:Y215	10.17	No	Yes	0	9	9
89	R:R:F128	R:R:L214	8.53	No	Yes	0	7	8
90	R:R:C133	R:R:D129	4.67	No	Yes	0	9	9
91	R:R:D129	R:R:Y140	6.9	Yes	Yes	2	9	9
92	R:R:D129	R:R:R144	8.34	Yes	Yes	2	9	9
93	R:R:R130	R:R:Y215	8.23	No	Yes	0	9	9
94	R:R:R130	R:R:Y453	6.17	No	Yes	5	9	9
95	R:R:F132	R:R:Y131	6.19	No	Yes	0	7	9
96	R:R:T135	R:R:Y131	16.23	No	Yes	0	9	9
97	R:R:L214	R:R:Y131	14.07	Yes	Yes	0	8	9
98	R:R:H217	R:R:Y131	5.44	No	Yes	0	7	9
99	R:R:F132	R:R:Y140	13.41	No	Yes	0	7	9
100	R:R:R144	R:R:Y140	14.4	Yes	Yes	2	9	9
101	R:R:A165	R:R:F161	6.93	No	No	0	7	7
102	R:R:L163	R:R:W164	11.39	No	Yes	0	8	8
103	R:R:T199	R:R:W164	8.49	No	Yes	0	9	8
104	R:R:F170	R:R:L169	4.87	No	No	0	7	6
105	R:R:V175	R:R:W171	7.36	No	No	0	5	7
106	R:R:Q188	R:R:W171	13.14	Yes	No	0	8	7
107	R:R:F189	R:R:W171	12.03	Yes	No	0	8	7
108	R:R:F173	R:R:Q172	7.03	No	No	0	6	7
109	R:R:Q172	R:R:R178	5.84	No	Yes	0	7	5
110	R:R:Q188	R:R:R178	5.84	Yes	Yes	0	8	5
111	R:R:Q188	R:R:T179	7.09	Yes	No	0	8	5
112	R:R:F186	R:R:V180	13.11	No	No	0	4	5
113	R:R:Q188	R:R:V180	5.73	Yes	No	0	8	5
114	R:R:F186	R:R:P181	5.78	No	No	0	4	3
115	R:R:Q184	W:W:?1	7.16	No	Yes	0	5	0
116	R:R:F189	R:R:I187	7.54	Yes	Yes	0	8	7
117	R:R:F189	R:R:V195	9.18	Yes	No	0	8	8
118	R:R:N192	R:R:P193	6.52	No	No	0	7	5
119	R:R:N192	R:R:V195	5.91	No	No	0	7	8
120	R:R:T196	R:R:T424	7.85	No	No	0	8	7
121	R:R:F197	R:R:L421	4.87	Yes	No	0	7	7
122	R:R:F197	R:R:F425	5.36	Yes	No	0	7	6
123	R:R:F204	R:R:Y205	10.32	Yes	Yes	0	9	8
124	R:R:F204	R:R:V208	9.18	Yes	No	0	9	8
125	R:R:F204	R:R:W413	5.01	Yes	Yes	0	9	9
126	R:R:F204	R:R:T414	5.19	Yes	No	0	9	7
127	R:R:F204	R:R:N417	15.71	Yes	No	0	9	9
128	R:R:L421	R:R:Y205	4.69	No	Yes	0	7	8
129	R:R:I218	R:R:Y215	4.84	No	Yes	0	9	9
130	R:R:I402	R:R:Y215	12.09	No	Yes	0	9	9
131	R:R:I405	R:R:Y215	4.84	No	Yes	0	9	9
132	R:R:E395	R:R:R223	10.47	No	No	0	9	7
133	R:R:F403	R:R:L407	4.87	No	No	0	8	8
134	R:R:I405	R:R:Y453	7.25	No	Yes	0	9	9
135	R:R:L407	R:R:L411	6.92	No	No	0	8	5
136	R:R:F409	R:R:W413	6.01	No	Yes	0	9	9
137	R:R:N445	R:R:T412	14.62	Yes	No	0	9	9
138	R:R:N445	R:R:W413	6.78	Yes	Yes	0	9	9
139	R:R:V420	R:R:Y416	6.31	No	Yes	1	8	9
140	R:R:W435	R:R:Y416	5.79	No	Yes	0	6	9
141	R:R:Y416	R:R:Y439	8.94	Yes	Yes	1	9	7
142	R:R:I430	R:R:V422	4.61	No	No	0	6	7
143	R:R:N423	R:R:W435	6.78	No	No	0	5	6
144	R:R:C426	R:R:C429	7.28	No	No	0	7	7
145	R:R:I430	R:R:V434	4.61	No	No	0	6	5
146	R:R:I430	R:R:W435	9.4	No	No	0	6	6
147	R:R:P431	R:R:V434	7.07	No	No	0	6	5
148	R:R:D432	W:W:?1	19.15	No	Yes	0	3	0
149	R:R:S436	W:W:?1	7.06	No	Yes	0	6	0
150	R:R:Y439	R:R:Y443	4.96	Yes	Yes	1	7	9
151	R:R:W440	R:R:Y443	4.82	Yes	Yes	1	9	9
152	R:R:N445	R:R:N449	12.26	Yes	No	0	9	9
153	R:R:A454	R:R:F460	6.93	No	Yes	0	9	9
154	R:R:F464	R:R:L455	7.31	Yes	No	0	9	8
155	R:R:N457	R:R:T459	8.77	No	No	0	9	8
156	R:R:F460	R:R:N457	6.04	Yes	No	0	9	9
157	R:R:I410	R:R:T414	4.56	No	No	0	8	7
158	R:R:M419	R:R:V434	4.56	No	No	0	7	5
159	R:R:K136	R:R:T139	4.5	No	No	0	7	7
160	R:R:L79	R:R:V47	4.47	No	No	0	9	7
161	R:R:N117	R:R:S160	4.47	No	No	0	9	9
162	R:R:F170	R:R:F173	4.29	No	No	0	7	6
163	R:R:I187	R:R:L190	4.28	Yes	No	0	7	5
164	R:R:L79	R:R:M54	4.24	No	No	0	9	8
165	R:R:P99	R:R:Y97	4.17	No	No	0	5	5
166	R:R:P141	R:R:Y140	4.17	No	Yes	0	7	9
167	R:R:A149	R:R:F70	4.16	No	Yes	0	8	8
168	R:R:A83	R:R:F84	4.16	No	No	0	5	6
169	R:R:H217	R:R:V213	4.15	No	No	0	7	5
170	R:R:A393	R:R:R396	4.15	No	No	0	6	7
171	R:R:F464	R:R:S56	3.96	Yes	No	0	9	9
172	R:R:F464	R:R:V53	3.93	Yes	No	0	9	9
173	R:R:F161	R:R:V114	3.93	No	No	0	7	8
174	R:R:F197	R:R:T424	3.89	Yes	No	0	7	7
175	R:R:F460	R:R:I57	3.77	Yes	No	0	9	9
176	R:R:F189	R:R:I168	3.77	Yes	No	0	8	8
177	R:R:F70	R:R:M152	3.73	Yes	No	0	8	8
178	R:R:V104	R:R:W98	3.68	No	Yes	0	6	9
179	R:R:V115	R:R:W157	3.68	No	Yes	0	8	9
180	R:R:I201	R:R:Y205	3.63	No	Yes	0	7	8
181	R:R:F460	R:R:N68	3.62	Yes	No	0	9	9
182	R:R:L71	R:R:Y453	3.52	No	Yes	0	8	9
183	R:R:L406	R:R:Y215	3.52	No	Yes	0	8	9
184	R:R:G438	R:R:M419	3.49	No	No	0	7	7
185	R:R:A75	R:R:V53	3.39	No	No	0	9	9
186	R:R:C456	R:R:T401	3.38	No	No	0	8	9
187	R:R:L100	R:R:P99	3.28	No	No	0	7	5
188	R:R:L206	R:R:P207	3.28	No	No	0	8	9
189	R:R:L441	R:R:P415	3.28	No	No	0	9	9
190	R:R:S160	R:R:V114	3.23	No	No	0	9	8
191	R:R:S222	R:R:V398	3.23	No	No	0	9	9
192	R:R:S219	R:R:T399	3.2	No	No	0	8	9
193	L:L:?1	R:R:A203	3.18	Yes	No	0	0	9
194	R:R:T447	R:R:V45	3.17	No	No	0	8	5
195	R:R:I437	R:R:S436	3.1	No	No	0	5	6
196	R:R:K462	R:R:T459	3	No	No	0	6	8
197	R:R:L42	R:R:V444	2.98	No	No	0	6	6
198	R:R:L44	R:R:V48	2.98	No	No	0	5	5
199	R:R:T433	W:W:?1	2.97	No	Yes	0	4	0
200	R:R:L406	R:R:T212	2.95	No	No	0	8	7
201	R:R:I51	R:R:M54	2.92	No	No	0	7	8
202	R:R:I210	R:R:L124	2.85	No	No	0	8	8
203	R:R:I210	R:R:L214	2.85	No	Yes	0	8	8
204	R:R:I437	R:R:L441	2.85	No	No	0	5	9
205	R:R:I448	R:R:N445	2.83	No	Yes	0	7	9
206	R:R:G101	R:R:W98	2.81	No	Yes	0	8	9
207	R:R:C76	R:R:F72	2.79	No	Yes	0	8	8
208	R:R:A102	R:R:R178	2.77	No	Yes	0	4	5
209	R:R:C452	R:R:Y453	2.69	No	Yes	0	9	9
210	R:R:A200	R:R:Y205	2.67	No	Yes	0	8	8
211	R:R:A77	R:R:W157	2.59	No	Yes	0	9	9
212	R:R:F84	R:R:I80	2.51	No	No	0	6	8
213	R:R:T146	R:R:Y69	2.5	No	No	0	6	7
214	R:R:F72	R:R:K58	2.48	Yes	No	0	8	5
215	R:R:A149	R:R:G150	1.95	No	No	0	8	5
216	R:R:A165	R:R:P166	1.87	No	No	0	7	9
217	R:R:G40	R:R:T39	1.82	No	Yes	0	6	7
218	R:R:A408	R:R:C452	1.81	No	No	0	8	9
219	R:R:G49	R:R:L52	1.71	No	No	0	9	8
220	R:R:A77	R:R:S119	1.71	No	No	0	9	9
221	R:R:C429	R:R:V422	1.71	No	No	0	7	7
222	R:R:A221	R:R:V134	1.7	No	No	0	8	9
223	R:R:A221	R:R:T135	1.68	No	No	0	8	9
224	R:R:K136	R:R:P137	1.67	No	No	0	7	9
225	R:R:L138	R:R:P137	1.64	No	No	0	7	9
226	R:R:S219	R:R:S222	1.63	No	No	0	8	9
227	R:R:A156	R:R:I125	1.62	No	No	0	9	8
228	R:R:S224	R:R:V226	1.62	No	No	0	6	6
229	R:R:V208	R:R:V209	1.6	No	No	0	8	5
230	R:R:T37	R:R:V33	1.59	No	No	0	5	6
231	R:R:T39	R:R:V38	1.59	Yes	No	0	7	5
232	R:R:T414	R:R:V418	1.59	No	No	0	7	7
233	R:R:A202	R:R:L163	1.58	No	No	0	7	8
234	R:R:A451	R:R:L455	1.58	No	No	0	7	8
235	R:R:A194	R:R:N192	1.56	No	No	0	5	7
236	R:R:I402	R:R:S219	1.55	No	No	0	9	8
237	R:R:I94	R:R:V91	1.54	No	No	0	7	8
238	R:R:M32	R:R:V33	1.52	No	No	0	6	6
239	R:R:I35	R:R:T39	1.52	No	Yes	1	7	7
240	R:R:I35	R:R:T90	1.52	No	No	1	7	8
241	R:R:K95	R:R:V91	1.52	No	No	0	5	8
242	R:R:I216	R:R:T212	1.52	No	No	0	4	7
243	R:R:F197	R:R:G198	1.51	Yes	No	0	7	7
244	R:R:K136	R:R:T135	1.5	No	No	0	7	9
245	R:R:K147	R:R:T145	1.5	No	No	0	6	9
246	R:R:K177	R:R:T179	1.5	No	No	0	3	5
247	R:R:L52	R:R:V48	1.49	No	No	0	8	5
248	R:R:E395	R:R:S222	1.44	No	No	0	9	9
249	R:R:Q427	R:R:S428	1.44	No	No	0	3	3
250	R:R:L159	R:R:M121	1.41	No	No	0	6	8
251	R:R:A167	R:R:F189	1.39	No	Yes	0	8	8
252	R:R:R394	R:R:S224	1.32	No	No	0	7	6
253	R:R:N423	R:R:Q427	1.32	No	No	0	5	3
254	R:R:R143	R:R:T139	1.29	No	No	0	6	7
255	R:R:H217	R:R:L220	1.29	No	No	0	7	4
256	R:R:I153	R:R:Y69	1.21	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.61182	11	1	0
2	R:R:T39	4.954	5	1	7
3	R:R:F70	4.542	5	0	8
4	R:R:F72	6.315	4	0	8
5	R:R:D78	8.6525	4	3	9
6	R:R:M86	6.08	5	1	9
7	R:R:Y89	9.792	5	1	8
8	R:R:W98	6.06	6	4	9
9	R:R:D112	7.135	4	1	9
10	R:R:Y113	11.816	5	1	9
11	R:R:D129	6.016	5	2	9
12	R:R:Y131	10.4825	4	0	9
13	R:R:Y140	9.72	4	2	9
14	R:R:R144	11.0125	4	2	9
15	R:R:W157	5.3825	4	0	9
16	R:R:W164	11.546	5	1	8
17	R:R:R178	5.6975	4	0	5
18	R:R:I187	7.1025	4	0	7
19	R:R:Q188	7.95	4	0	8
20	R:R:F189	6.782	5	0	8
21	R:R:F197	3.9075	4	0	7
22	R:R:F204	9.082	5	0	9
23	R:R:Y205	5.3275	4	0	8
24	R:R:L214	7.865	4	0	8
25	R:R:Y215	7.28167	6	0	9
26	R:R:W413	7.388	5	0	9
27	R:R:Y416	8.194	5	1	9
28	R:R:Y439	9.22	4	1	7
29	R:R:W440	7.0825	4	1	9
30	R:R:Y443	6.37	5	1	9
31	R:R:N445	9.1225	4	0	9
32	R:R:Y453	5.64167	6	5	9
33	R:R:F460	7.482	5	0	9
34	R:R:F464	5.6275	4	0	9
35	W:W:?1	8.528	5	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D112	14.7659	8.21	Yes	Yes	1	0	9
2	R:R:D112	R:R:Y443	15.4857	5.75	Yes	Yes	1	9	9
3	R:R:W440	R:R:Y443	10.4903	4.82	Yes	Yes	1	9	9
4	R:R:T39	R:R:W440	13.3415	7.28	Yes	Yes	1	7	9
5	L:L:?1	R:R:Y439	28.3559	7.09	Yes	Yes	1	0	7
6	R:R:Y439	R:R:Y443	13.6669	4.96	Yes	Yes	1	7	9
7	R:R:Y439	R:R:Y89	15.6189	15.89	Yes	Yes	1	7	8
8	R:R:M86	R:R:Y443	16.7589	8.38	Yes	Yes	1	9	9
9	L:L:?1	R:R:W413	88.2596	13.01	Yes	Yes	0	0	9
10	R:R:N445	R:R:W413	95.4708	6.78	Yes	Yes	0	9	9
11	R:R:N445	R:R:N449	96.4008	12.26	Yes	No	0	9	9
12	R:R:L74	R:R:N449	95.5144	8.24	No	No	3	9	9
13	R:R:L123	R:R:L74	99.7669	5.54	No	No	0	9	9
14	R:R:L123	R:R:Y453	100	9.38	No	Yes	0	9	9
15	R:R:R130	R:R:Y453	50.1435	6.17	No	Yes	5	9	9
16	R:R:R130	R:R:Y215	50.4201	8.23	No	Yes	0	9	9
17	R:R:S127	R:R:Y215	94.7997	10.17	No	Yes	0	9	9
18	R:R:L214	R:R:S127	93.6725	6.01	Yes	No	0	8	9
19	R:R:L214	R:R:Y131	88.321	14.07	Yes	Yes	0	8	9
20	R:R:F132	R:R:Y131	80.5743	6.19	No	Yes	0	7	9
21	R:R:F132	R:R:Y140	79.8955	13.41	No	Yes	0	7	9
22	R:R:D129	R:R:Y140	47.8686	6.9	Yes	Yes	2	9	9
23	R:R:D129	R:R:N67	30.6614	5.39	Yes	No	2	9	9
24	R:R:N67	R:R:T65	58.2616	5.85	No	No	0	9	8
25	R:R:N68	R:R:T65	56.4479	8.77	No	No	0	9	8
26	R:R:F460	R:R:N68	54.6265	3.62	Yes	No	0	9	9
27	R:R:F460	R:R:L63	30.7742	17.05	Yes	No	0	9	9
28	R:R:L63	R:R:N60	25.1409	6.87	No	No	0	9	8
29	R:R:N60	R:R:T463	21.329	8.77	No	No	0	8	9
30	R:R:S56	R:R:T463	19.4154	6.4	No	No	0	9	9
31	R:R:F464	R:R:S56	17.4967	3.96	Yes	No	0	9	9
32	R:R:I405	R:R:Y453	50.31	7.25	No	Yes	0	9	9
33	R:R:I405	R:R:Y215	50.2587	4.84	No	Yes	0	9	9
34	R:R:R144	R:R:Y140	30.6512	14.4	Yes	Yes	2	9	9
35	R:R:N67	R:R:R144	29.1193	10.85	No	Yes	2	9	9
36	R:R:F460	R:R:I57	15.5293	3.77	Yes	No	0	9	9
37	R:R:F72	R:R:I57	13.6003	8.79	Yes	No	0	8	9
38	R:R:D129	R:R:F70	18.7878	4.78	Yes	Yes	0	9	8
39	R:R:F70	R:R:I153	13.2852	5.02	Yes	No	0	8	9
40	R:R:I153	R:R:S73	10.2956	6.19	No	No	0	9	9
41	L:L:?1	R:R:Y113	32.5443	22.06	Yes	Yes	1	0	9
42	R:R:I187	R:R:Y113	36.9556	10.88	Yes	Yes	0	7	9
43	R:R:I187	R:R:L109	14.192	5.71	Yes	No	0	7	8
44	R:R:Y89	W:W:?1	10.5031	6.3	Yes	Yes	0	8	0
45	R:R:C185	R:R:L109	11.4817	4.76	No	No	0	9	8
46	R:R:F189	R:R:I187	23.0377	7.54	Yes	Yes	0	8	7
47	R:R:F189	R:R:W171	16.3977	12.03	Yes	No	0	8	7
48	R:R:Q188	R:R:W171	14.3688	13.14	Yes	No	0	8	7
49	L:L:?1	R:R:W164	11.4279	12.25	Yes	Yes	1	0	8
50	R:R:F204	R:R:W413	15.7521	5.01	Yes	Yes	0	9	9
51	R:R:F204	R:R:Y205	12.035	10.32	Yes	Yes	0	9	8
52	L:L:?1	R:R:Y416	10.621	14.97	Yes	Yes	1	0	9
53	R:R:W435	R:R:Y416	12.5038	5.79	No	Yes	0	6	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D112	8.21	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y113	22.06	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:S116	9.08	1	Yes	No	0	8	0	1
L:L:?1	R:R:W164	12.25	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W413	13.01	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y416	14.97	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:N417	5.54	1	Yes	No	0	9	0	1
L:L:?1	R:R:V420	5.01	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y439	7.09	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:C442	5.33	1	Yes	No	0	9	0	1
R:R:I81	R:R:S116	4.64	0	No	No	9	8	2	1
R:R:D112	R:R:S85	8.83	1	Yes	No	9	9	1	2
R:R:Y439	R:R:Y89	15.89	1	Yes	Yes	7	8	1	2
R:R:Y443	R:R:Y89	7.94	1	Yes	Yes	9	8	2	2
R:R:D112	R:R:Y113	5.75	1	Yes	Yes	9	9	1	1
R:R:D112	R:R:Y443	5.75	1	Yes	Yes	9	9	1	2
R:R:W164	R:R:Y113	15.43	1	Yes	Yes	8	9	1	1
R:R:I187	R:R:Y113	10.88	0	Yes	Yes	7	9	2	1
R:R:Y113	R:R:Y416	4.96	1	Yes	Yes	9	9	1	1
R:R:N117	R:R:W164	10.17	0	No	Yes	9	8	2	1
R:R:V120	R:R:W413	6.13	0	No	Yes	9	9	2	1
R:R:L163	R:R:W164	11.39	0	No	Yes	8	8	2	1
R:R:T199	R:R:W164	8.49	0	No	Yes	9	8	2	1
R:R:F204	R:R:W413	5.01	0	Yes	Yes	9	9	2	1
R:R:F204	R:R:N417	15.71	0	Yes	No	9	9	2	1
R:R:F409	R:R:W413	6.01	0	No	Yes	9	9	2	1
R:R:N445	R:R:W413	6.78	0	Yes	Yes	9	9	2	1
R:R:V420	R:R:Y416	6.31	1	No	Yes	8	9	1	1
R:R:W435	R:R:Y416	5.79	0	No	Yes	6	9	2	1
R:R:Y416	R:R:Y439	8.94	1	Yes	Yes	9	7	1	1
R:R:Y439	R:R:Y443	4.96	1	Yes	Yes	7	9	1	2
L:L:?1	R:R:A203	3.18	1	Yes	No	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I93	R:R:Y89	7.25	0	No	Yes	7	8	2	1
R:R:Y439	R:R:Y89	15.89	1	Yes	Yes	7	8	2	1
R:R:W440	R:R:Y89	11.58	1	Yes	Yes	9	8	2	1
R:R:Y443	R:R:Y89	7.94	1	Yes	Yes	9	8	2	1
R:R:Y89	W:W:?1	6.3	1	Yes	Yes	8	0	1	0
R:R:Q184	R:R:Y92	6.76	0	No	No	5	8	1	2
R:R:Q184	W:W:?1	7.16	0	No	Yes	5	0	1	0
R:R:D432	W:W:?1	19.15	0	No	Yes	3	0	1	0
R:R:S436	W:W:?1	7.06	0	No	Yes	6	0	1	0
R:R:Y439	R:R:Y443	4.96	1	Yes	Yes	7	9	2	2
R:R:W440	R:R:Y443	4.82	1	Yes	Yes	9	9	2	2
R:R:I437	R:R:S436	3.1	0	No	No	5	6	2	1
R:R:T433	W:W:?1	2.97	0	No	Yes	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FX5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.59
Number of Linked Nodes	243
Number of Links	256
Number of Hubs	35
Number of Links mediated by Hubs	136
Number of Communities	5
Number of Nodes involved in Communities	27
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	58372
Length Of Smallest Path	3
Average Path Length	18.1465
Length of Longest Path	38
Minimum Path Strength	1.38
Average Path Strength	8.17699
Maximum Path Strength	17.535
Minimum Path Correlation	0.7
Average Path Correlation	0.923841
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	39.6382
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.3479
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • GTPase activating protein binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • protein localization to postsynaptic specialization membrane • protein localization to postsynaptic membrane • protein localization to cell periphery • cellular localization • protein localization to synapse • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • macromolecule localization • protein localization to organelle • protein localization to postsynapse • intracellular protein localization • regulation of biological quality • protein localization to cell junction • receptor localization to synapse • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • trans-synaptic signaling • regulation of signaling • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of biological process • negative regulation of synaptic transmission • negative regulation of cell communication • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of cellular process • regulation of cell communication • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • glutamatergic synapse • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	XNO
PDB Residues	L:L:?1 W:W:?1
Environment Details	Open EMBL-EBI Page
Code	XNO
Name	Xanomeline
Synonyms	(5M)-5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine
Identifier
Formula	C14 H23 N3 O S
Molecular Weight	281.417
SMILES
PubChem	60809
Formal Charge	0
Total Atoms	42
Total Chiral Atoms	0
Total Bonds	43
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>8FX5_nogp_Chain_R M V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G Y W P L G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F I Q F L S N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F K K T F R H L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	doi.org/10.1038/nature17188
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	doi.org/10.1038/nature25758
	6KP6	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	-	3	2020-03-11	doi.org/10.1107/S2052252520000597
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275	Gi1/β1/γ2	3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275		3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	9M4Q	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenergic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9IQS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	Muscarinic toxin 3	-	3.6	2025-07-23	To be published
	9M42	A	Orphan	Orphan	GPR139	Homo sapiens	A1L8O	-	chim(Gs-CtGq)/β1/γ2	3.2	2026-01-21	10.1038/s41467-025-66845-y
	9M42 (No Gprot)	A	Orphan	Orphan	GPR139	Homo sapiens	A1L8O	-		3.2	2026-01-21	10.1038/s41467-025-66845-y

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