psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D112	8.21	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y113	22.06	Yes	Yes	1	0	9
3	L:L:?1	R:R:S116	9.08	Yes	No	0	0	8
4	L:L:?1	R:R:W164	12.25	Yes	Yes	1	0	8
5	L:L:?1	R:R:W413	13.01	Yes	Yes	0	0	9
6	L:L:?1	R:R:Y416	14.97	Yes	Yes	1	0	9
7	L:L:?1	R:R:N417	5.54	Yes	No	0	0	9
8	L:L:?1	R:R:V420	5.01	Yes	No	1	0	8
9	L:L:?1	R:R:Y439	7.09	Yes	Yes	1	0	7
10	L:L:?1	R:R:C442	5.33	Yes	No	0	0	9
11	R:R:T39	R:R:T90	12.56	Yes	No	1	7	8
12	R:R:T39	R:R:W440	7.28	Yes	Yes	1	7	9
13	R:R:L42	R:R:T447	5.9	No	No	0	6	8
14	R:R:M86	R:R:S43	4.6	Yes	No	0	9	8
15	R:R:N87	R:R:S43	5.96	No	No	0	9	8
16	R:R:M86	R:R:T46	7.53	Yes	No	0	9	8
17	R:R:T447	R:R:T46	12.56	No	No	0	8	8
18	R:R:D78	R:R:N50	8.08	Yes	No	0	9	9
19	R:R:N50	R:R:P450	9.77	No	No	0	9	9
20	R:R:F464	R:R:L52	7.31	Yes	No	0	9	8
21	R:R:F72	R:R:M54	11.2	Yes	No	0	8	8
22	R:R:S56	R:R:T463	6.4	No	No	0	9	9
23	R:R:F72	R:R:I57	8.79	Yes	No	0	8	9
24	R:R:N60	R:R:Q62	6.6	No	No	0	8	6
25	R:R:L63	R:R:N60	6.87	No	No	0	9	8
26	R:R:N60	R:R:T463	8.77	No	No	0	8	9
27	R:R:Q64	R:R:R61	14.02	No	No	0	8	8
28	R:R:L63	R:R:T459	5.9	No	No	0	9	8
29	R:R:F460	R:R:L63	17.05	Yes	No	0	9	9
30	R:R:N67	R:R:T65	5.85	No	No	0	9	8
31	R:R:N68	R:R:T65	8.77	No	No	0	9	8
32	R:R:R144	R:R:V66	10.46	Yes	No	0	9	8
33	R:R:D129	R:R:N67	5.39	Yes	No	2	9	9
34	R:R:N67	R:R:R144	10.85	No	Yes	2	9	9
35	R:R:F70	R:R:I125	5.02	Yes	No	0	8	8
36	R:R:D129	R:R:F70	4.78	Yes	Yes	0	9	8
37	R:R:F70	R:R:I153	5.02	Yes	No	0	8	9
38	R:R:N122	R:R:S73	8.94	No	No	0	9	9
39	R:R:I153	R:R:S73	6.19	No	No	0	9	9
40	R:R:S73	R:R:W157	6.18	No	Yes	0	9	9
41	R:R:D78	R:R:L74	8.14	Yes	No	3	9	9
42	R:R:L123	R:R:L74	5.54	No	No	0	9	9
43	R:R:L74	R:R:N449	8.24	No	No	3	9	9
44	R:R:D78	R:R:S446	10.31	Yes	No	0	9	9
45	R:R:D78	R:R:N449	8.08	Yes	No	3	9	9
46	R:R:I80	R:R:V115	9.22	No	No	0	8	8
47	R:R:I81	R:R:S116	4.64	No	No	0	9	8
48	R:R:I81	R:R:S446	9.29	No	No	0	9	9
49	R:R:G82	R:R:M86	5.24	No	Yes	0	9	9
50	R:R:D112	R:R:S85	8.83	Yes	No	0	9	9
51	R:R:M86	R:R:W440	4.65	Yes	Yes	1	9	9
52	R:R:M86	R:R:Y443	8.38	Yes	Yes	1	9	9
53	R:R:L88	R:R:W108	10.25	No	No	0	7	7
54	R:R:I93	R:R:Y89	7.25	No	Yes	0	7	8
55	R:R:Y439	R:R:Y89	15.89	Yes	Yes	1	7	8
56	R:R:W440	R:R:Y89	11.58	Yes	Yes	1	9	8
57	R:R:Y443	R:R:Y89	7.94	Yes	Yes	1	9	8
58	R:R:Y89	W:W:?1	6.3	Yes	Yes	0	8	0
59	R:R:W98	R:R:Y92	8.68	Yes	No	0	9	8
60	R:R:Q184	R:R:Y92	6.76	No	No	0	5	8
61	R:R:K95	R:R:P99	6.69	No	No	0	5	5
62	R:R:N183	R:R:Y97	11.63	No	No	0	4	5
63	R:R:L100	R:R:W98	6.83	No	Yes	0	7	9
64	R:R:C105	R:R:W98	5.22	No	Yes	4	9	9
65	R:R:C185	R:R:W98	9.14	No	Yes	4	9	9
66	R:R:C105	R:R:C185	7.28	No	No	4	9	9
67	R:R:D106	R:R:R178	8.34	No	Yes	0	8	5
68	R:R:L109	R:R:W108	5.69	No	No	0	8	7
69	R:R:C185	R:R:L109	4.76	No	No	0	9	8
70	R:R:I187	R:R:L109	5.71	Yes	No	0	7	8
71	R:R:A110	R:R:L169	4.73	No	No	0	8	6
72	R:R:D112	R:R:Y113	5.75	Yes	Yes	1	9	9
73	R:R:D112	R:R:Y443	5.75	Yes	Yes	1	9	9
74	R:R:W164	R:R:Y113	15.43	Yes	Yes	1	8	9
75	R:R:I187	R:R:Y113	10.88	Yes	Yes	0	7	9
76	R:R:Y113	R:R:Y416	4.96	Yes	Yes	1	9	9
77	R:R:M121	R:R:N117	5.61	No	No	0	8	9
78	R:R:N117	R:R:W164	10.17	No	Yes	0	9	8
79	R:R:A118	R:R:W157	9.08	No	Yes	0	9	9
80	R:R:V120	R:R:W413	6.13	No	Yes	0	9	9
81	R:R:L123	R:R:Y453	9.38	No	Yes	0	9	9
82	R:R:F128	R:R:L124	4.87	No	No	0	7	8
83	R:R:L124	R:R:P207	4.93	No	No	0	8	9
84	R:R:I126	R:R:R130	6.26	No	No	5	9	9
85	R:R:I126	R:R:Y453	4.84	No	Yes	5	9	9
86	R:R:M211	R:R:S127	4.6	No	No	0	9	9
87	R:R:L214	R:R:S127	6.01	Yes	No	0	8	9
88	R:R:S127	R:R:Y215	10.17	No	Yes	0	9	9
89	R:R:F128	R:R:L214	8.53	No	Yes	0	7	8
90	R:R:C133	R:R:D129	4.67	No	Yes	0	9	9
91	R:R:D129	R:R:Y140	6.9	Yes	Yes	2	9	9
92	R:R:D129	R:R:R144	8.34	Yes	Yes	2	9	9
93	R:R:R130	R:R:Y215	8.23	No	Yes	0	9	9
94	R:R:R130	R:R:Y453	6.17	No	Yes	5	9	9
95	R:R:F132	R:R:Y131	6.19	No	Yes	0	7	9
96	R:R:T135	R:R:Y131	16.23	No	Yes	0	9	9
97	R:R:L214	R:R:Y131	14.07	Yes	Yes	0	8	9
98	R:R:H217	R:R:Y131	5.44	No	Yes	0	7	9
99	R:R:F132	R:R:Y140	13.41	No	Yes	0	7	9
100	R:R:R144	R:R:Y140	14.4	Yes	Yes	2	9	9
101	R:R:A165	R:R:F161	6.93	No	No	0	7	7
102	R:R:L163	R:R:W164	11.39	No	Yes	0	8	8
103	R:R:T199	R:R:W164	8.49	No	Yes	0	9	8
104	R:R:F170	R:R:L169	4.87	No	No	0	7	6
105	R:R:V175	R:R:W171	7.36	No	No	0	5	7
106	R:R:Q188	R:R:W171	13.14	Yes	No	0	8	7
107	R:R:F189	R:R:W171	12.03	Yes	No	0	8	7
108	R:R:F173	R:R:Q172	7.03	No	No	0	6	7
109	R:R:Q172	R:R:R178	5.84	No	Yes	0	7	5
110	R:R:Q188	R:R:R178	5.84	Yes	Yes	0	8	5
111	R:R:Q188	R:R:T179	7.09	Yes	No	0	8	5
112	R:R:F186	R:R:V180	13.11	No	No	0	4	5
113	R:R:Q188	R:R:V180	5.73	Yes	No	0	8	5
114	R:R:F186	R:R:P181	5.78	No	No	0	4	3
115	R:R:Q184	W:W:?1	7.16	No	Yes	0	5	0
116	R:R:F189	R:R:I187	7.54	Yes	Yes	0	8	7
117	R:R:F189	R:R:V195	9.18	Yes	No	0	8	8
118	R:R:N192	R:R:P193	6.52	No	No	0	7	5
119	R:R:N192	R:R:V195	5.91	No	No	0	7	8
120	R:R:T196	R:R:T424	7.85	No	No	0	8	7
121	R:R:F197	R:R:L421	4.87	Yes	No	0	7	7
122	R:R:F197	R:R:F425	5.36	Yes	No	0	7	6
123	R:R:F204	R:R:Y205	10.32	Yes	Yes	0	9	8
124	R:R:F204	R:R:V208	9.18	Yes	No	0	9	8
125	R:R:F204	R:R:W413	5.01	Yes	Yes	0	9	9
126	R:R:F204	R:R:T414	5.19	Yes	No	0	9	7
127	R:R:F204	R:R:N417	15.71	Yes	No	0	9	9
128	R:R:L421	R:R:Y205	4.69	No	Yes	0	7	8
129	R:R:I218	R:R:Y215	4.84	No	Yes	0	9	9
130	R:R:I402	R:R:Y215	12.09	No	Yes	0	9	9
131	R:R:I405	R:R:Y215	4.84	No	Yes	0	9	9
132	R:R:E395	R:R:R223	10.47	No	No	0	9	7
133	R:R:F403	R:R:L407	4.87	No	No	0	8	8
134	R:R:I405	R:R:Y453	7.25	No	Yes	0	9	9
135	R:R:L407	R:R:L411	6.92	No	No	0	8	5
136	R:R:F409	R:R:W413	6.01	No	Yes	0	9	9
137	R:R:N445	R:R:T412	14.62	Yes	No	0	9	9
138	R:R:N445	R:R:W413	6.78	Yes	Yes	0	9	9
139	R:R:V420	R:R:Y416	6.31	No	Yes	1	8	9
140	R:R:W435	R:R:Y416	5.79	No	Yes	0	6	9
141	R:R:Y416	R:R:Y439	8.94	Yes	Yes	1	9	7
142	R:R:I430	R:R:V422	4.61	No	No	0	6	7
143	R:R:N423	R:R:W435	6.78	No	No	0	5	6
144	R:R:C426	R:R:C429	7.28	No	No	0	7	7
145	R:R:I430	R:R:V434	4.61	No	No	0	6	5
146	R:R:I430	R:R:W435	9.4	No	No	0	6	6
147	R:R:P431	R:R:V434	7.07	No	No	0	6	5
148	R:R:D432	W:W:?1	19.15	No	Yes	0	3	0
149	R:R:S436	W:W:?1	7.06	No	Yes	0	6	0
150	R:R:Y439	R:R:Y443	4.96	Yes	Yes	1	7	9
151	R:R:W440	R:R:Y443	4.82	Yes	Yes	1	9	9
152	R:R:N445	R:R:N449	12.26	Yes	No	0	9	9
153	R:R:A454	R:R:F460	6.93	No	Yes	0	9	9
154	R:R:F464	R:R:L455	7.31	Yes	No	0	9	8
155	R:R:N457	R:R:T459	8.77	No	No	0	9	8
156	R:R:F460	R:R:N457	6.04	Yes	No	0	9	9
157	R:R:I410	R:R:T414	4.56	No	No	0	8	7
158	R:R:M419	R:R:V434	4.56	No	No	0	7	5
159	R:R:K136	R:R:T139	4.5	No	No	0	7	7
160	R:R:L79	R:R:V47	4.47	No	No	0	9	7
161	R:R:N117	R:R:S160	4.47	No	No	0	9	9
162	R:R:F170	R:R:F173	4.29	No	No	0	7	6
163	R:R:I187	R:R:L190	4.28	Yes	No	0	7	5
164	R:R:L79	R:R:M54	4.24	No	No	0	9	8
165	R:R:P99	R:R:Y97	4.17	No	No	0	5	5
166	R:R:P141	R:R:Y140	4.17	No	Yes	0	7	9
167	R:R:A149	R:R:F70	4.16	No	Yes	0	8	8
168	R:R:A83	R:R:F84	4.16	No	No	0	5	6
169	R:R:H217	R:R:V213	4.15	No	No	0	7	5
170	R:R:A393	R:R:R396	4.15	No	No	0	6	7
171	R:R:F464	R:R:S56	3.96	Yes	No	0	9	9
172	R:R:F464	R:R:V53	3.93	Yes	No	0	9	9
173	R:R:F161	R:R:V114	3.93	No	No	0	7	8
174	R:R:F197	R:R:T424	3.89	Yes	No	0	7	7
175	R:R:F460	R:R:I57	3.77	Yes	No	0	9	9
176	R:R:F189	R:R:I168	3.77	Yes	No	0	8	8
177	R:R:F70	R:R:M152	3.73	Yes	No	0	8	8
178	R:R:V104	R:R:W98	3.68	No	Yes	0	6	9
179	R:R:V115	R:R:W157	3.68	No	Yes	0	8	9
180	R:R:I201	R:R:Y205	3.63	No	Yes	0	7	8
181	R:R:F460	R:R:N68	3.62	Yes	No	0	9	9
182	R:R:L71	R:R:Y453	3.52	No	Yes	0	8	9
183	R:R:L406	R:R:Y215	3.52	No	Yes	0	8	9
184	R:R:G438	R:R:M419	3.49	No	No	0	7	7
185	R:R:A75	R:R:V53	3.39	No	No	0	9	9
186	R:R:C456	R:R:T401	3.38	No	No	0	8	9
187	R:R:L100	R:R:P99	3.28	No	No	0	7	5
188	R:R:L206	R:R:P207	3.28	No	No	0	8	9
189	R:R:L441	R:R:P415	3.28	No	No	0	9	9
190	R:R:S160	R:R:V114	3.23	No	No	0	9	8
191	R:R:S222	R:R:V398	3.23	No	No	0	9	9
192	R:R:S219	R:R:T399	3.2	No	No	0	8	9
193	L:L:?1	R:R:A203	3.18	Yes	No	0	0	9
194	R:R:T447	R:R:V45	3.17	No	No	0	8	5
195	R:R:I437	R:R:S436	3.1	No	No	0	5	6
196	R:R:K462	R:R:T459	3	No	No	0	6	8
197	R:R:L42	R:R:V444	2.98	No	No	0	6	6
198	R:R:L44	R:R:V48	2.98	No	No	0	5	5
199	R:R:T433	W:W:?1	2.97	No	Yes	0	4	0
200	R:R:L406	R:R:T212	2.95	No	No	0	8	7
201	R:R:I51	R:R:M54	2.92	No	No	0	7	8
202	R:R:I210	R:R:L124	2.85	No	No	0	8	8
203	R:R:I210	R:R:L214	2.85	No	Yes	0	8	8
204	R:R:I437	R:R:L441	2.85	No	No	0	5	9
205	R:R:I448	R:R:N445	2.83	No	Yes	0	7	9
206	R:R:G101	R:R:W98	2.81	No	Yes	0	8	9
207	R:R:C76	R:R:F72	2.79	No	Yes	0	8	8
208	R:R:A102	R:R:R178	2.77	No	Yes	0	4	5
209	R:R:C452	R:R:Y453	2.69	No	Yes	0	9	9
210	R:R:A200	R:R:Y205	2.67	No	Yes	0	8	8
211	R:R:A77	R:R:W157	2.59	No	Yes	0	9	9
212	R:R:F84	R:R:I80	2.51	No	No	0	6	8
213	R:R:T146	R:R:Y69	2.5	No	No	0	6	7
214	R:R:F72	R:R:K58	2.48	Yes	No	0	8	5
215	R:R:A149	R:R:G150	1.95	No	No	0	8	5
216	R:R:A165	R:R:P166	1.87	No	No	0	7	9
217	R:R:G40	R:R:T39	1.82	No	Yes	0	6	7
218	R:R:A408	R:R:C452	1.81	No	No	0	8	9
219	R:R:G49	R:R:L52	1.71	No	No	0	9	8
220	R:R:A77	R:R:S119	1.71	No	No	0	9	9
221	R:R:C429	R:R:V422	1.71	No	No	0	7	7
222	R:R:A221	R:R:V134	1.7	No	No	0	8	9
223	R:R:A221	R:R:T135	1.68	No	No	0	8	9
224	R:R:K136	R:R:P137	1.67	No	No	0	7	9
225	R:R:L138	R:R:P137	1.64	No	No	0	7	9
226	R:R:S219	R:R:S222	1.63	No	No	0	8	9
227	R:R:A156	R:R:I125	1.62	No	No	0	9	8
228	R:R:S224	R:R:V226	1.62	No	No	0	6	6
229	R:R:V208	R:R:V209	1.6	No	No	0	8	5
230	R:R:T37	R:R:V33	1.59	No	No	0	5	6
231	R:R:T39	R:R:V38	1.59	Yes	No	0	7	5
232	R:R:T414	R:R:V418	1.59	No	No	0	7	7
233	R:R:A202	R:R:L163	1.58	No	No	0	7	8
234	R:R:A451	R:R:L455	1.58	No	No	0	7	8
235	R:R:A194	R:R:N192	1.56	No	No	0	5	7
236	R:R:I402	R:R:S219	1.55	No	No	0	9	8
237	R:R:I94	R:R:V91	1.54	No	No	0	7	8
238	R:R:M32	R:R:V33	1.52	No	No	0	6	6
239	R:R:I35	R:R:T39	1.52	No	Yes	1	7	7
240	R:R:I35	R:R:T90	1.52	No	No	1	7	8
241	R:R:K95	R:R:V91	1.52	No	No	0	5	8
242	R:R:I216	R:R:T212	1.52	No	No	0	4	7
243	R:R:F197	R:R:G198	1.51	Yes	No	0	7	7
244	R:R:K136	R:R:T135	1.5	No	No	0	7	9
245	R:R:K147	R:R:T145	1.5	No	No	0	6	9
246	R:R:K177	R:R:T179	1.5	No	No	0	3	5
247	R:R:L52	R:R:V48	1.49	No	No	0	8	5
248	R:R:E395	R:R:S222	1.44	No	No	0	9	9
249	R:R:Q427	R:R:S428	1.44	No	No	0	3	3
250	R:R:L159	R:R:M121	1.41	No	No	0	6	8
251	R:R:A167	R:R:F189	1.39	No	Yes	0	8	8
252	R:R:R394	R:R:S224	1.32	No	No	0	7	6
253	R:R:N423	R:R:Q427	1.32	No	No	0	5	3
254	R:R:R143	R:R:T139	1.29	No	No	0	6	7
255	R:R:H217	R:R:L220	1.29	No	No	0	7	4
256	R:R:I153	R:R:Y69	1.21	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.61182	11	1	0
2	R:R:T39	4.954	5	1	7
3	R:R:F70	4.542	5	0	8
4	R:R:F72	6.315	4	0	8
5	R:R:D78	8.6525	4	3	9
6	R:R:M86	6.08	5	1	9
7	R:R:Y89	9.792	5	1	8
8	R:R:W98	6.06	6	4	9
9	R:R:D112	7.135	4	1	9
10	R:R:Y113	11.816	5	1	9
11	R:R:D129	6.016	5	2	9
12	R:R:Y131	10.4825	4	0	9
13	R:R:Y140	9.72	4	2	9
14	R:R:R144	11.0125	4	2	9
15	R:R:W157	5.3825	4	0	9
16	R:R:W164	11.546	5	1	8
17	R:R:R178	5.6975	4	0	5
18	R:R:I187	7.1025	4	0	7
19	R:R:Q188	7.95	4	0	8
20	R:R:F189	6.782	5	0	8
21	R:R:F197	3.9075	4	0	7
22	R:R:F204	9.082	5	0	9
23	R:R:Y205	5.3275	4	0	8
24	R:R:L214	7.865	4	0	8
25	R:R:Y215	7.28167	6	0	9
26	R:R:W413	7.388	5	0	9
27	R:R:Y416	8.194	5	1	9
28	R:R:Y439	9.22	4	1	7
29	R:R:W440	7.0825	4	1	9
30	R:R:Y443	6.37	5	1	9
31	R:R:N445	9.1225	4	0	9
32	R:R:Y453	5.64167	6	5	9
33	R:R:F460	7.482	5	0	9
34	R:R:F464	5.6275	4	0	9
35	W:W:?1	8.528	5	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D112	14.7659	8.21	Yes	Yes	1	0	9
2	R:R:D112	R:R:Y443	15.4857	5.75	Yes	Yes	1	9	9
3	R:R:W440	R:R:Y443	10.4903	4.82	Yes	Yes	1	9	9
4	R:R:T39	R:R:W440	13.3415	7.28	Yes	Yes	1	7	9
5	L:L:?1	R:R:Y439	28.3559	7.09	Yes	Yes	1	0	7
6	R:R:Y439	R:R:Y443	13.6669	4.96	Yes	Yes	1	7	9
7	R:R:Y439	R:R:Y89	15.6189	15.89	Yes	Yes	1	7	8
8	R:R:M86	R:R:Y443	16.7589	8.38	Yes	Yes	1	9	9
9	L:L:?1	R:R:W413	88.2596	13.01	Yes	Yes	0	0	9
10	R:R:N445	R:R:W413	95.4708	6.78	Yes	Yes	0	9	9
11	R:R:N445	R:R:N449	96.4008	12.26	Yes	No	0	9	9
12	R:R:L74	R:R:N449	95.5144	8.24	No	No	3	9	9
13	R:R:L123	R:R:L74	99.7669	5.54	No	No	0	9	9
14	R:R:L123	R:R:Y453	100	9.38	No	Yes	0	9	9
15	R:R:R130	R:R:Y453	50.1435	6.17	No	Yes	5	9	9
16	R:R:R130	R:R:Y215	50.4201	8.23	No	Yes	0	9	9
17	R:R:S127	R:R:Y215	94.7997	10.17	No	Yes	0	9	9
18	R:R:L214	R:R:S127	93.6725	6.01	Yes	No	0	8	9
19	R:R:L214	R:R:Y131	88.321	14.07	Yes	Yes	0	8	9
20	R:R:F132	R:R:Y131	80.5743	6.19	No	Yes	0	7	9
21	R:R:F132	R:R:Y140	79.8955	13.41	No	Yes	0	7	9
22	R:R:D129	R:R:Y140	47.8686	6.9	Yes	Yes	2	9	9
23	R:R:D129	R:R:N67	30.6614	5.39	Yes	No	2	9	9
24	R:R:N67	R:R:T65	58.2616	5.85	No	No	0	9	8
25	R:R:N68	R:R:T65	56.4479	8.77	No	No	0	9	8
26	R:R:F460	R:R:N68	54.6265	3.62	Yes	No	0	9	9
27	R:R:F460	R:R:L63	30.7742	17.05	Yes	No	0	9	9
28	R:R:L63	R:R:N60	25.1409	6.87	No	No	0	9	8
29	R:R:N60	R:R:T463	21.329	8.77	No	No	0	8	9
30	R:R:S56	R:R:T463	19.4154	6.4	No	No	0	9	9
31	R:R:F464	R:R:S56	17.4967	3.96	Yes	No	0	9	9
32	R:R:I405	R:R:Y453	50.31	7.25	No	Yes	0	9	9
33	R:R:I405	R:R:Y215	50.2587	4.84	No	Yes	0	9	9
34	R:R:R144	R:R:Y140	30.6512	14.4	Yes	Yes	2	9	9
35	R:R:N67	R:R:R144	29.1193	10.85	No	Yes	2	9	9
36	R:R:F460	R:R:I57	15.5293	3.77	Yes	No	0	9	9
37	R:R:F72	R:R:I57	13.6003	8.79	Yes	No	0	8	9
38	R:R:D129	R:R:F70	18.7878	4.78	Yes	Yes	0	9	8
39	R:R:F70	R:R:I153	13.2852	5.02	Yes	No	0	8	9
40	R:R:I153	R:R:S73	10.2956	6.19	No	No	0	9	9
41	L:L:?1	R:R:Y113	32.5443	22.06	Yes	Yes	1	0	9
42	R:R:I187	R:R:Y113	36.9556	10.88	Yes	Yes	0	7	9
43	R:R:I187	R:R:L109	14.192	5.71	Yes	No	0	7	8
44	R:R:Y89	W:W:?1	10.5031	6.3	Yes	Yes	0	8	0
45	R:R:C185	R:R:L109	11.4817	4.76	No	No	0	9	8
46	R:R:F189	R:R:I187	23.0377	7.54	Yes	Yes	0	8	7
47	R:R:F189	R:R:W171	16.3977	12.03	Yes	No	0	8	7
48	R:R:Q188	R:R:W171	14.3688	13.14	Yes	No	0	8	7
49	L:L:?1	R:R:W164	11.4279	12.25	Yes	Yes	1	0	8
50	R:R:F204	R:R:W413	15.7521	5.01	Yes	Yes	0	9	9
51	R:R:F204	R:R:Y205	12.035	10.32	Yes	Yes	0	9	8
52	L:L:?1	R:R:Y416	10.621	14.97	Yes	Yes	1	0	9
53	R:R:W435	R:R:Y416	12.5038	5.79	No	Yes	0	6	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D112	8.21	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y113	22.06	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:S116	9.08	1	Yes	No	0	8	0	1
L:L:?1	R:R:W164	12.25	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W413	13.01	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y416	14.97	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:N417	5.54	1	Yes	No	0	9	0	1
L:L:?1	R:R:V420	5.01	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y439	7.09	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:C442	5.33	1	Yes	No	0	9	0	1
R:R:I81	R:R:S116	4.64	0	No	No	9	8	2	1
R:R:D112	R:R:S85	8.83	1	Yes	No	9	9	1	2
R:R:Y439	R:R:Y89	15.89	1	Yes	Yes	7	8	1	2
R:R:Y443	R:R:Y89	7.94	1	Yes	Yes	9	8	2	2
R:R:D112	R:R:Y113	5.75	1	Yes	Yes	9	9	1	1
R:R:D112	R:R:Y443	5.75	1	Yes	Yes	9	9	1	2
R:R:W164	R:R:Y113	15.43	1	Yes	Yes	8	9	1	1
R:R:I187	R:R:Y113	10.88	0	Yes	Yes	7	9	2	1
R:R:Y113	R:R:Y416	4.96	1	Yes	Yes	9	9	1	1
R:R:N117	R:R:W164	10.17	0	No	Yes	9	8	2	1
R:R:V120	R:R:W413	6.13	0	No	Yes	9	9	2	1
R:R:L163	R:R:W164	11.39	0	No	Yes	8	8	2	1
R:R:T199	R:R:W164	8.49	0	No	Yes	9	8	2	1
R:R:F204	R:R:W413	5.01	0	Yes	Yes	9	9	2	1
R:R:F204	R:R:N417	15.71	0	Yes	No	9	9	2	1
R:R:F409	R:R:W413	6.01	0	No	Yes	9	9	2	1
R:R:N445	R:R:W413	6.78	0	Yes	Yes	9	9	2	1
R:R:V420	R:R:Y416	6.31	1	No	Yes	8	9	1	1
R:R:W435	R:R:Y416	5.79	0	No	Yes	6	9	2	1
R:R:Y416	R:R:Y439	8.94	1	Yes	Yes	9	7	1	1
R:R:Y439	R:R:Y443	4.96	1	Yes	Yes	7	9	1	2
L:L:?1	R:R:A203	3.18	1	Yes	No	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I93	R:R:Y89	7.25	0	No	Yes	7	8	2	1
R:R:Y439	R:R:Y89	15.89	1	Yes	Yes	7	8	2	1
R:R:W440	R:R:Y89	11.58	1	Yes	Yes	9	8	2	1
R:R:Y443	R:R:Y89	7.94	1	Yes	Yes	9	8	2	1
R:R:Y89	W:W:?1	6.3	1	Yes	Yes	8	0	1	0
R:R:Q184	R:R:Y92	6.76	0	No	No	5	8	1	2
R:R:Q184	W:W:?1	7.16	0	No	Yes	5	0	1	0
R:R:D432	W:W:?1	19.15	0	No	Yes	3	0	1	0
R:R:S436	W:W:?1	7.06	0	No	Yes	6	0	1	0
R:R:Y439	R:R:Y443	4.96	1	Yes	Yes	7	9	2	2
R:R:W440	R:R:Y443	4.82	1	Yes	Yes	9	9	2	2
R:R:I437	R:R:S436	3.1	0	No	No	5	6	2	1
R:R:T433	W:W:?1	2.97	0	No	Yes	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FX5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.59
Number of Linked Nodes	243
Number of Links	256
Number of Hubs	35
Number of Links mediated by Hubs	136
Number of Communities	5
Number of Nodes involved in Communities	27
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	58372
Length Of Smallest Path	3
Average Path Length	18.1465
Length of Longest Path	38
Minimum Path Strength	1.38
Average Path Strength	8.17699
Maximum Path Strength	17.535
Minimum Path Correlation	0.7
Average Path Correlation	0.923841
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	39.6382
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.3479
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	XNO
PDB Residues	L:L:?1 W:W:?1
Environment Details	Open EMBL-EBI Page
Code	XNO
Name	Xanomeline
Synonyms	(5M)-5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine
Identifier
Formula	C14 H23 N3 O S
Molecular Weight	281.417
SMILES
PubChem	60809
Formal Charge	0
Total Atoms	42
Total Chiral Atoms	0
Total Bonds	43
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>8FX5_nogp_Chain_R M V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G Y W P L G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F I Q F L S N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F K K T F R H L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275	Gi1/β1/γ2	3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275		3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	doi.org/10.1038/nature17188
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	6KP6	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	-	3	2020-03-11	doi.org/10.1107/S2052252520000597
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	9M4Q	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	doi.org/10.1038/nature25758
	9IQS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	Muscarinic toxin 3	-	3.6	2025-07-23	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8FX5_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.