Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 3.9654182
2A:A:V34 5.296525
3A:A:L36 4.1425427
4A:A:L38 4.474528
5A:A:I184 5.84419
6A:A:F189 7.322529
7A:A:F191 9.8125425
8A:A:F196 7.874527
9A:A:K197 9.802516
10A:A:F199 9.64667615
11A:A:V201 5.978519
12A:A:Q204 3.3375409
13A:A:K210 7.1925419
14A:A:W211 5.335419
15A:A:C214 4.546517
16A:A:F215 5.23819
17A:A:I221 4.1354198
18A:A:I222 3.145427
19A:A:F223 4.67409
20A:A:D229 5.1275498
21A:A:Y230 5.60571798
22A:A:D231 6.39499
23A:A:L232 5.5225498
24A:A:F250 5.38509
25A:A:W258 8.88333615
26A:A:F259 5.69254199
27A:A:I265 2.892528
28A:A:L266 3.7575409
29A:A:F267 3.865629
30A:A:L268 6.405408
31A:A:K270 8.3325409
32A:A:F274 5.544599
33A:A:K277 9.1975499
34A:A:S281 3.205497
35A:A:L283 4.43497
36A:A:C286 4.3275496
37A:A:Y287 5.574507
38A:A:Y290 10.26754217
39A:A:C325 5.9325427
40A:A:V332 5.0925427
41A:A:L348 4.225409
42A:A:F354 5.496505
43B:B:L14 3.124158
44B:B:I18 3.585157
45B:B:L30 5.755405
46B:B:V40 4.3885163
47B:B:R48 3.64547
48B:B:R49 4.9475447
49B:B:H54 7.6756139
50B:B:K57 6.4875419
51B:B:Y59 8.428518
52B:B:W63 7.63857747
53B:B:R68 9.038545
54B:B:Q75 7.5675419
55B:B:K78 6.4525408
56B:B:L79 5.08487
57B:B:W82 12.3945139
58B:B:S84 5.455445
59B:B:Y85 13.29444
60B:B:K89 7.523336139
61B:B:H91 5.9485
62B:B:I93 6.806587
63B:B:L95 4.13688
64B:B:W99 7.7619
65B:B:Y105 4.485686
66B:B:Y111 8.61404
67B:B:C114 3.764588
68B:B:I120 4.9575406
69B:B:Y124 6.63333686
70B:B:L126 4.185485
71B:B:V133 5.33484
72B:B:L139 6.454579
73B:B:H142 8.486579
74B:B:Y145 4.69429718
75B:B:L146 4.828577
76B:B:C149 3.78478
77B:B:R150 8.01466
78B:B:F151 5.396509
79B:B:L152 4.5325463
80B:B:N155 4.70754233
81B:B:I157 4.315677
82B:B:V158 4.575465
83B:B:T159 6.7025479
84B:B:D163 6.2479
85B:B:C166 4.245468
86B:B:L168 5.39466
87B:B:W169 9.00143778
88B:B:F180 8.794567
89B:B:H183 9.228569
90B:B:D186 4.996519
91B:B:M188 5.376518
92B:B:L190 5.278565
93B:B:L192 4.865465
94B:B:F199 6.29857769
95B:B:V200 5.8175416
96B:B:S201 5.6525469
97B:B:C204 3.9675417
98B:B:K209 8.5175466
99B:B:L210 5.1025405
100B:B:W211 8.37857768
101B:B:F222 7.706518
102B:B:H225 7.828519
103B:B:D228 7.3175419
104B:B:I229 4.1725417
105B:B:I232 4.528518
106B:B:F234 6.64415
107B:B:F235 5.5756106
108B:B:N239 5.99754102
109B:B:F241 7.30667616
110B:B:T243 4.972518
111B:B:S245 5.5025419
112B:B:D247 5.89519
113B:B:T249 5.885416
114B:B:R251 9.634518
115B:B:F253 6.8675416
116B:B:R256 8.2354109
117B:B:D258 9.82417
118B:B:Q259 3.798506
119B:B:Y264 5.524297145
120B:B:H266 5.23404
121B:B:R283 9.37254169
122B:B:L286 4.39417
123B:B:Y289 6.421676147
124B:B:D290 10.09416
125B:B:C294 4.2025405
126B:B:N295 6.16754146
127B:B:W297 4.863336148
128B:B:K301 4.36254165
129B:B:H311 9.89519
130B:B:N313 5.1125417
131B:B:R314 13.97418
132B:B:V320 4.3725417
133B:B:M325 4.82645
134B:B:T329 6.125408
135B:B:W332 9.71857719
136B:B:D333 6.245619
137B:B:K337 9.28516
138B:B:I338 4.395445
139B:B:W339 8.94333619
140B:B:N340 6.2449
141G:G:L19 3.8525159
142G:G:K20 3.82754156
143G:G:Y40 9.444106
144G:G:N59 5.19649
145G:G:P60 8.9825449
146G:G:F61 5.79778948
147R:R:V38 2.37405
148R:R:I57 3.9725439
149R:R:L63 5.388539
150R:R:F70 5.046538
151R:R:L74 3.2775439
152R:R:D78 5.7525439
153R:R:M86 4.9325119
154R:R:Y89 11.314118
155R:R:I93 6.2175407
156R:R:W98 6.541437249
157R:R:W108 9.29754117
158R:R:D112 6.894119
159R:R:Y113 4.8475409
160R:R:V115 3.93408
161R:R:N117 6.562559
162R:R:V120 3.3025459
163R:R:M121 4.325458
164R:R:N122 4.145439
165R:R:L123 3.895439
166R:R:F128 5.235437
167R:R:D129 8.39254179
168R:R:Y131 6509
169R:R:K136 6.594257
170R:R:Y140 9.5985179
171R:R:R144 7.696676179
172R:R:W157 5.3625409
173R:R:W164 10.755458
174R:R:V180 6.874125
175R:R:P181 6.384123
176R:R:Q188 7.594128
177R:R:F189 6.8145268
178R:R:I201 4.2525407
179R:R:F204 12.1475409
180R:R:I210 2.772538
181R:R:M211 3.38439
182R:R:L214 4.91438
183R:R:Y215 6.39439
184R:R:E395 4.155409
185R:R:T401 2.6275409
186R:R:L406 4.2725438
187R:R:I410 3.6675408
188R:R:T412 5.365459
189R:R:W413 7.16375859
190R:R:Y416 5.425659
191R:R:M419 6.875457
192R:R:I430 5.238556
193R:R:W435 5.1925456
194R:R:Y439 11.81254117
195R:R:Y443 8.125119
196R:R:N445 7.284559
197R:R:Y453 6.125439
198R:R:T459 5.41408
199R:R:F460 4.91539
200R:R:T463 5.21439
201R:R:F464 4.876539
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:R68 B:B:Y85 12.745718.52YesYes454
2B:B:Y85 G:G:P60 12.89816.69YesYes449
3B:B:M325 G:G:P60 13.55038.39YesYes459
4B:B:M325 G:G:P49 16.915.03YesNo057
5B:B:G324 G:G:P49 17.3954.06NoNo097
6B:B:G324 B:B:K280 17.47573.49NoNo091
7B:B:K280 G:G:E47 17.55659.45NoNo013
8G:G:E47 G:G:H44 17.63732.46NoNo036
9G:G:H44 G:G:Y40 17.960217.42NoYes066
10B:B:F235 G:G:Y40 18.45926.19YesYes1066
11B:B:F235 B:B:F278 18.84726.43YesNo067
12B:B:F278 B:B:L285 19.0048.53NoNo076
13B:B:L285 B:B:W297 18.99325.69NoYes1468
14B:B:W297 B:B:Y289 20.80997.72YesYes1487
15B:B:C271 B:B:Y289 22.21644.03NoYes057
16B:B:C271 B:B:D290 22.60336.22NoYes056
17B:B:D290 B:B:T274 11.29215.78YesNo168
18B:B:S316 B:B:T274 11.32863.2NoNo198
19B:B:S316 B:B:Y59 11.3642.54NoYes198
20A:A:C214 B:B:Y59 27.78388.06YesYes178
21A:A:C214 A:A:F215 29.19652.79YesYes179
22A:A:F215 A:A:L37 23.37119.74YesNo099
23A:A:I221 A:A:L37 24.95264.28YesNo089
24A:A:I221 A:A:I264 24.21782.94YesNo086
25A:A:F250 A:A:I264 24.10283.77YesNo096
26A:A:F250 A:A:L266 11.27983.65YesYes099
27A:A:L227 A:A:L268 1009.69NoYes078
28A:A:F274 A:A:L227 1004.87YesNo097
29A:A:F274 A:A:Y230 1004.13YesYes998
30A:A:K277 A:A:Y230 1009.55YesYes998
31A:A:K277 A:A:S228 1009.18YesNo099
32A:A:L273 A:A:S228 1003NoNo069
33A:A:K270 A:A:L273 1007.05YesNo096
34A:A:K270 A:A:N269 10019.58YesNo099
35A:A:C224 A:A:N269 1006.3NoNo079
36A:A:C224 A:A:F267 1002.79NoYes079
37A:A:F267 A:A:I222 1002.51YesYes297
38A:A:I222 A:A:L36 1004.28YesYes277
39A:A:L36 A:A:V34 52.6874.47YesYes275
40A:A:L194 A:A:V34 52.452.98NoYes245
41A:A:L194 R:R:L138 10011.07NoNo047
42R:R:L138 R:R:T139 1002.95NoNo077
43R:R:K136 R:R:T139 1004.5YesNo2577
44R:R:F132 R:R:K136 64.135512.41NoYes077
45R:R:F132 R:R:Y140 23.768914.44NoYes079
46B:B:D290 B:B:R314 11.44325.01YesYes168
47B:B:R314 B:B:W332 11.458920.99YesYes189
48B:B:W332 B:B:Y59 16.38789.65YesYes198
49A:A:R208 A:A:W211 94.64643NoYes199
50A:A:L249 A:A:R208 94.48896.07NoNo199
51A:A:F223 A:A:L249 94.49974.87YesNo099
52A:A:F223 A:A:V225 93.01713.93YesNo097
53A:A:L268 A:A:V225 92.95764.47YesNo087
54A:A:F250 A:A:L310 13.3948.53YesNo094
55A:A:L310 A:A:M247 13.23677.07NoNo046
56A:A:M247 A:A:Y287 13.07043.59NoYes067
57A:A:C286 A:A:Y287 10.39624.03YesYes067
58A:A:F196 A:A:L36 53.52444.87YesYes277
59A:A:F196 A:A:L194 52.59938.53YesNo274
60B:B:M188 B:B:Y145 46.67474.79YesYes188
61A:A:Q204 B:B:Y145 66.83164.51YesYes098
62B:B:C204 B:B:D228 68.88034.67YesYes179
63B:B:C204 B:B:D186 45.58933.11YesYes179
64A:A:S206 B:B:D186 22.28065.89NoYes089
65A:A:K210 B:B:D228 23.32959.68YesYes199
66R:R:R144 R:R:Y140 19.981711.32YesYes1799
67R:R:F132 R:R:Y131 40.3675.16NoYes079
68R:R:L214 R:R:Y131 79.64484.69YesYes089
69R:R:L214 R:R:S127 37.81996.01YesNo389
70R:R:M211 R:R:S127 30.03813.07YesNo399
71R:R:L123 R:R:M211 23.75562.83YesYes399
72R:R:K136 R:R:T135 40.41934.5YesNo079
73R:R:T135 R:R:Y131 40.3179.99NoYes099
74B:B:D258 B:B:F222 78.62028.36YesYes178
75B:B:D258 B:B:R22 39.533911.91YesNo076
76B:B:I18 B:B:R22 37.83095.01YesNo076
77B:B:I18 B:B:L14 12.56552.85YesYes1578
78B:B:L14 G:G:K20 10.47982.82YesYes1586
79B:B:D258 G:G:R27 38.8315.96YesNo078
80B:B:I18 G:G:R27 37.78622.51YesNo078
81G:G:E22 G:G:L19 57.49546.63NoYes099
82B:B:I18 G:G:L19 61.65464.28YesYes1579
83B:B:C218 G:G:E22 55.63116.08NoNo059
84B:B:C218 B:B:W211 47.28585.22NoYes658
85B:B:F199 B:B:W211 29.206110.02YesYes698
86B:B:F180 B:B:W211 10.433318.04YesYes678
87B:B:L168 B:B:Q156 11.12955.32YesNo065
88B:B:L152 B:B:Q156 11.12986.65YesNo035
89B:B:D153 B:B:Q156 19.47689.14NoNo055
90B:B:D153 B:B:N155 16.69444.04NoYes053
91B:B:I229 B:B:T243 16.54476.08YesYes178
92B:B:H225 B:B:T243 33.08528.21YesYes198
93B:B:H225 B:B:S245 30.56469.76YesYes199
94B:B:I229 B:B:S245 16.65283.1YesYes179
95B:B:D247 B:B:H225 30.57052.52YesYes199
96B:B:F253 B:B:R251 41.5844.28YesYes168
97B:B:S227 B:B:S245 47.26693.26NoYes169
98B:B:D247 B:B:S227 44.87584.42YesNo196
99B:B:R251 B:B:T249 13.9793.88YesYes186
100R:R:L123 R:R:L74 19.55612.77YesYes399
101R:R:D78 R:R:L74 29.05984.07YesYes399
102R:R:D78 R:R:S446 28.11414.42YesNo099
103R:R:S446 R:R:Y443 27.18292.54NoYes099
104R:R:S85 R:R:Y443 10.74467.63NoYes1199
105R:R:S85 R:R:W108 10.44684.94NoYes1197
106R:R:L88 R:R:W108 20.260921.64NoYes077
107R:R:L88 R:R:W98 19.62797.97NoYes079
108R:R:A149 R:R:R144 16.03914.15NoYes089
109R:R:A149 R:R:F70 15.93572.77NoYes088
110R:R:F70 R:R:N122 12.6723.62YesYes389
111R:R:Y439 R:R:Y443 14.215613.9YesYes1179
112R:R:W108 R:R:Y439 10.44156.75YesYes1177
113R:R:F128 R:R:L214 14.29796.09YesYes378
114R:R:F128 R:R:L124 13.46327.31YesNo378
115R:R:L124 R:R:P207 26.49853.28NoNo089
116R:R:P207 R:R:V120 39.1153.53NoYes099
117R:R:V120 R:R:W413 25.87913.68YesYes599
118R:R:I210 R:R:L214 27.33012.85YesYes388
119R:R:I210 R:R:L124 13.45622.85YesNo388
120R:R:I210 R:R:L206 13.45682.85YesNo088
121R:R:L206 R:R:P207 13.24673.28NoNo089
122R:R:W413 R:R:Y416 18.95862.89YesYes599
123R:R:P99 R:R:W98 10.76615.4NoYes2459
124R:R:P99 R:R:Y97 10.1334.17NoNo055
125R:R:I410 R:R:L406 10.11424.28YesYes088
126R:R:W435 R:R:Y416 11.3846.75YesYes569
127A:A:V201 A:A:W211 85.51649.81YesYes199
128A:A:Q204 A:A:V201 89.0362.87YesYes099
129A:A:Q204 A:A:S206 22.28734.33YesNo098
130B:B:D186 B:B:Y145 23.3365.75YesYes198
131A:A:K210 B:B:M188 23.32328.64YesYes198
132B:B:C204 B:B:M188 23.32323.24YesYes178
133B:B:D228 B:B:S227 92.18612.94YesNo196
134B:B:F253 B:B:T243 41.78873.89YesYes168
135B:B:F222 B:B:F253 79.8979.65YesYes186
136B:B:H225 B:B:R251 27.945714.67YesYes198
137B:B:D247 B:B:T249 14.204110.12YesYes196
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7V69
Class A
SubFamily Amine
Type Acetylcholine (muscarinic)
SubType M4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.4
Date 2022-05-11
D.O.I. 10.1038/s41467-022-30595-y
Net Summary
Imin 2.51
Number of Linked Nodes 826
Number of Links 1079
Number of Hubs 201
Number of Links mediated by Hubs 711
Number of Communities 26
Number of Nodes involved in Communities 317
Number of Links involved in Communities 476
Path Summary
Number Of Nodes in MetaPath 138
Number Of Links MetaPath 137
Number of Shortest Paths 21027292
Length Of Smallest Path 3
Average Path Length 65.5499
Length of Longest Path 82
Minimum Path Strength 1.185
Average Path Strength 8.00449
Maximum Path Strength 23
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.78571
Average % Of Corr. Nodes 28.0516
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 67.2388
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • neurotransmitter receptor activity   • G protein-coupled amine receptor activity   • G protein-coupled acetylcholine receptor activity   • postsynaptic neurotransmitter receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • G protein-coupled neurotransmitter receptor activity   • acetylcholine receptor activity   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway   • cell surface receptor signaling pathway   • trans-synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • regulation of locomotion   • locomotion   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • postsynapse   • postsynaptic membrane   • plasma membrane region   • synaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7V69_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKS 
TIVKQMKTG IVETHFTFK DLHFKMFDV GGQRSERKK WIHCFEGVT 
AIIFCVALS DYDLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC ATDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7V69_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7V69_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP08173
Sequence
>7V69_Chain_R
TVEMVFIAT VTGSLSLVT VVGNILVML SIKVNRQLQ TVNNYFLFS 
LACADLIIG AFSMNLYTV YIIKGYWPL GAVVCDLWL ALDYVVSNA 
SVMNLLIIS FDRYFCVTK PLTYPARRT TKMAGLMIA AAWVLSFVL 
WAPAILFWQ FVVGKRTVP DNQCFIQFL SNPAVTFGT AIAAFYLPV 
VIMTVLYIH ISLASRSMA ARERKVTRT IFAILLAFI LTWTPYNVM 
VLVNTFCQS CIPDTVWSI GYWLCYVNS TINPACYAL CNATFKKTF 
RHLLLCQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FX5AAmineAcetylcholine (muscarinic)M4Homo sapiensXanomelineXanomelineGi1/β1/γ22.452023-09-1310.1038/s41467-023-41199-5
8FX5 (No Gprot) AAmineAcetylcholine (muscarinic)M4Homo sapiensXanomelineXanomeline2.452023-09-1310.1038/s41467-023-41199-5
7TRSAAmineAcetylcholine (muscarinic)M4Homo sapiensAcetylcholine-Gi1/β1/γ22.82023-05-1710.2139/ssrn.4034884
7TRS (No Gprot) AAmineAcetylcholine (muscarinic)M4Homo sapiensAcetylcholine-2.82023-05-1710.2139/ssrn.4034884
7TRQAAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxoVU0467154Gi1/β1/γ22.52023-05-1710.2139/ssrn.4034884
7TRQ (No Gprot) AAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxoVU04671542.52023-05-1710.2139/ssrn.4034884
7TRPAAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxoLY2033298Gi1/β1/γ22.42023-05-1710.2139/ssrn.4034884
7TRP (No Gprot) AAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxoLY20332982.42023-05-1710.2139/ssrn.4034884
7TRKAAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxo-Gi1/β1/γ22.82023-05-1710.2139/ssrn.4034884
7TRK (No Gprot) AAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxo-2.82023-05-1710.2139/ssrn.4034884
8E9XAAmineAcetylcholine (muscarinic)M4Homo sapiens2-Deoxycytidine-chim(NtGi1-Go)/β1/γ22.72022-11-3010.1038/s41586-022-05489-0
8E9X (No Gprot) AAmineAcetylcholine (muscarinic)M4Homo sapiens2-Deoxycytidine-2.72022-11-3010.1038/s41586-022-05489-0
7UM4AAmine5-Hydroxytryptamine5-HT5AHomo sapiensAS2674723--2.82022-07-2010.1038/s41594-022-00796-6
7V6AAAmineAcetylcholine (muscarinic)M4Homo sapiensPubChem 9864275-Gi1/β1/γ23.62022-05-1110.1038/s41467-022-30595-y
7V6A (No Gprot) AAmineAcetylcholine (muscarinic)M4Homo sapiensPubChem 9864275-3.62022-05-1110.1038/s41467-022-30595-y
7V69 (No Gprot) AAmineAcetylcholine (muscarinic)M4Homo sapiens--3.42022-05-1110.1038/s41467-022-30595-y
7V68AAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxoPubChem 57664406Gi1/β1/γ23.42022-05-1110.1038/s41467-022-30595-y
7V68 (No Gprot) AAmineAcetylcholine (muscarinic)M4Homo sapiensIperoxoPubChem 576644063.42022-05-1110.1038/s41467-022-30595-y
6KP6AAmineAcetylcholine (muscarinic)M4Homo sapiens---32020-03-1110.1107/S2052252520000597
6CM4AAmineDopamineD2Homo sapiensRisperidone--2.872018-03-1410.1038/nature25758
5OM4ANucleotideAdenosineA2AHomo sapiensPubChem 135566609Na-22018-01-1710.1038/s41598-017-18570-w
5NM4ANucleotideAdenosineA2AHomo sapiensZM-241385Na-1.72017-09-2710.1038/s41467-017-00630-4
5DSGAAmineAcetylcholine (muscarinic)M4Homo sapiensTiotropium--2.62016-03-1610.1038/nature17188




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