psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E28	R:R:E31	5.07	No	No	0	5	6
2	R:R:I94	R:R:M32	4.37	No	No	0	7	6
3	R:R:F34	R:R:V38	3.93	No	No	0	4	5
4	R:R:I35	R:R:I94	4.42	No	No	0	7	7
5	R:R:T39	R:R:W440	7.28	No	No	0	7	9
6	R:R:N87	R:R:S43	7.45	No	No	0	9	8
7	R:R:G82	R:R:T46	3.64	No	Yes	0	9	8
8	R:R:M86	R:R:T46	4.52	No	Yes	0	9	8
9	R:R:S446	R:R:T46	6.4	No	Yes	0	9	8
10	R:R:A75	R:R:N50	4.69	No	No	0	9	9
11	R:R:D78	R:R:N50	13.46	Yes	No	0	9	9
12	R:R:N50	R:R:P450	8.15	No	Yes	0	9	9
13	R:R:F464	R:R:L52	17.05	No	No	0	9	8
14	R:R:F72	R:R:M54	8.71	No	Yes	0	8	8
15	R:R:S56	R:R:T463	6.4	No	No	0	9	9
16	R:R:I57	R:R:N68	4.25	No	Yes	0	9	9
17	R:R:N60	R:R:Q62	3.96	No	No	0	8	6
18	R:R:L63	R:R:N60	8.24	No	No	0	9	8
19	R:R:Q64	R:R:R61	11.68	No	No	0	8	8
20	R:R:L63	R:R:T459	8.84	No	No	0	9	8
21	R:R:F460	R:R:L63	13.4	Yes	No	0	9	9
22	R:R:Q64	R:R:Y69	6.76	No	No	0	8	7
23	R:R:N68	R:R:T65	7.31	Yes	No	0	9	8
24	R:R:R144	R:R:V66	10.46	Yes	No	0	9	8
25	R:R:D129	R:R:N67	9.42	Yes	No	3	9	9
26	R:R:N67	R:R:R144	3.62	No	Yes	3	9	9
27	R:R:L71	R:R:N68	4.12	No	Yes	0	8	9
28	R:R:F460	R:R:N68	4.83	Yes	Yes	0	9	9
29	R:R:F70	R:R:I125	7.54	Yes	Yes	0	8	8
30	R:R:F70	R:R:I126	3.77	Yes	No	0	8	9
31	R:R:D129	R:R:F70	9.55	Yes	Yes	0	9	8
32	R:R:F70	R:R:I153	6.28	Yes	No	0	8	9
33	R:R:L71	R:R:Y453	3.52	No	Yes	0	8	9
34	R:R:N122	R:R:S73	10.43	No	No	5	9	9
35	R:R:S73	R:R:W157	6.18	No	Yes	5	9	9
36	R:R:D78	R:R:L74	4.07	Yes	No	1	9	9
37	R:R:L123	R:R:L74	5.54	No	No	0	9	9
38	R:R:L74	R:R:N449	4.12	No	No	1	9	9
39	R:R:D78	R:R:S446	8.83	Yes	No	0	9	9
40	R:R:D78	R:R:N449	12.12	Yes	No	1	9	9
41	R:R:I80	R:R:L111	4.28	No	No	0	8	6
42	R:R:I80	R:R:V115	10.75	No	No	0	8	8
43	R:R:I81	R:R:S85	7.74	Yes	No	1	9	9
44	R:R:I81	R:R:Y443	3.63	Yes	Yes	1	9	9
45	R:R:I81	R:R:S446	4.64	Yes	No	0	9	9
46	R:R:F84	R:R:L111	3.65	No	No	0	6	6
47	R:R:D112	R:R:S85	10.31	No	No	1	9	9
48	R:R:S85	R:R:Y443	3.82	No	Yes	1	9	9
49	R:R:M86	R:R:Y443	7.18	No	Yes	0	9	9
50	R:R:L88	R:R:W108	10.25	No	No	0	7	7
51	R:R:Y89	R:R:Y92	4.96	Yes	No	0	8	8
52	R:R:I93	R:R:Y89	4.84	No	Yes	1	7	8
53	R:R:Y439	R:R:Y89	6.95	Yes	Yes	1	7	8
54	R:R:W440	R:R:Y89	4.82	No	Yes	1	9	8
55	R:R:P99	R:R:V91	3.53	Yes	No	0	5	8
56	R:R:W98	R:R:Y92	5.79	Yes	No	0	9	8
57	R:R:I93	R:R:W440	3.52	No	No	1	7	9
58	R:R:K95	R:R:Y97	11.94	No	No	2	5	5
59	R:R:K95	R:R:P99	6.69	No	Yes	2	5	5
60	R:R:P99	R:R:Y97	5.56	Yes	No	2	5	5
61	R:R:P99	R:R:W98	5.4	Yes	Yes	2	5	9
62	R:R:L100	R:R:W98	5.69	No	Yes	2	7	9
63	R:R:C105	R:R:W98	15.67	No	Yes	2	9	9
64	R:R:C185	R:R:W98	5.22	No	Yes	2	9	9
65	R:R:L100	R:R:P99	4.93	No	Yes	2	7	5
66	R:R:L100	R:R:V104	5.96	No	No	0	7	6
67	R:R:A102	R:R:R178	4.15	No	No	0	4	5
68	R:R:C105	R:R:C185	7.28	No	No	2	9	9
69	R:R:D106	R:R:L169	8.14	No	Yes	0	8	6
70	R:R:L107	R:R:L169	4.15	No	Yes	0	7	6
71	R:R:L109	R:R:W108	5.69	No	No	0	8	7
72	R:R:I187	R:R:L109	8.56	Yes	No	0	7	8
73	R:R:A110	R:R:L169	4.73	No	Yes	0	8	6
74	R:R:D112	R:R:Y443	10.34	No	Yes	1	9	9
75	L:L:?1	R:R:D112	8.07	Yes	No	1	0	9
76	R:R:C113	R:R:W164	9.14	No	Yes	1	9	8
77	L:L:?1	R:R:C113	4.19	Yes	No	1	0	9
78	R:R:F161	R:R:V114	5.24	No	No	0	7	8
79	R:R:S116	R:R:W413	3.71	No	Yes	1	8	9
80	L:L:?1	R:R:S116	9.92	Yes	No	1	0	8
81	R:R:M121	R:R:N117	8.41	No	No	0	8	9
82	R:R:N117	R:R:S160	8.94	No	No	0	9	9
83	R:R:N117	R:R:W164	7.91	No	Yes	0	9	8
84	R:R:A118	R:R:W157	7.78	No	Yes	0	9	9
85	R:R:P207	R:R:V120	3.53	No	No	0	9	9
86	R:R:F409	R:R:V120	3.93	Yes	No	1	9	9
87	R:R:V120	R:R:W413	6.13	No	Yes	1	9	9
88	R:R:I125	R:R:N122	4.25	Yes	No	0	8	9
89	R:R:N122	R:R:W157	4.52	No	Yes	5	9	9
90	R:R:F409	R:R:L123	4.87	Yes	No	0	9	9
91	R:R:L123	R:R:Y453	10.55	No	Yes	0	9	9
92	R:R:F128	R:R:L124	3.65	No	No	6	7	8
93	R:R:L124	R:R:P207	4.93	No	No	0	8	9
94	R:R:I210	R:R:L124	4.28	No	No	6	8	8
95	R:R:I126	R:R:R130	6.26	No	No	4	9	9
96	R:R:I126	R:R:Y453	6.04	No	Yes	4	9	9
97	R:R:S127	R:R:Y215	5.09	No	Yes	0	9	9
98	R:R:F128	R:R:I210	3.77	No	No	6	7	8
99	R:R:F128	R:R:L214	8.53	No	No	0	7	8
100	R:R:C133	R:R:D129	4.67	No	Yes	0	9	9
101	R:R:D129	R:R:R144	11.91	Yes	Yes	3	9	9
102	R:R:R130	R:R:Y215	8.23	No	Yes	0	9	9
103	R:R:R130	R:R:Y453	6.17	No	Yes	4	9	9
104	R:R:F132	R:R:Y131	6.19	No	Yes	0	7	9
105	R:R:T135	R:R:Y131	14.98	No	Yes	0	9	9
106	R:R:L214	R:R:Y131	9.38	No	Yes	0	8	9
107	R:R:F132	R:R:K136	4.96	No	No	0	7	7
108	R:R:F132	R:R:Y140	17.54	No	Yes	0	7	9
109	R:R:C133	R:R:Y140	4.03	No	Yes	0	9	9
110	R:R:I218	R:R:V134	7.68	No	No	0	9	9
111	R:R:P141	R:R:Y140	4.17	No	Yes	0	7	9
112	R:R:R144	R:R:Y140	22.64	Yes	Yes	0	9	9
113	R:R:M148	R:R:R143	4.96	No	No	0	8	6
114	R:R:M148	R:R:R144	7.44	No	Yes	0	8	9
115	R:R:L163	R:R:W164	11.39	No	Yes	0	8	8
116	R:R:T199	R:R:W164	8.49	No	Yes	1	9	8
117	L:L:?1	R:R:W164	24.08	Yes	Yes	1	0	8
118	R:R:I168	R:R:I187	4.42	No	Yes	0	8	7
119	R:R:F170	R:R:F173	4.29	No	No	0	7	6
120	R:R:V175	R:R:W171	25.74	No	No	0	5	7
121	R:R:Q188	R:R:W171	12.05	No	No	0	8	7
122	R:R:F189	R:R:W171	11.02	Yes	No	0	8	7
123	R:R:F173	R:R:Q172	17.57	No	No	0	6	7
124	R:R:Q172	R:R:R178	11.68	No	No	0	7	5
125	R:R:Q172	R:R:Q188	7.68	No	No	0	7	8
126	R:R:R178	R:R:V180	3.92	No	No	0	5	5
127	R:R:Q188	R:R:T179	7.09	No	No	0	8	5
128	R:R:P181	R:R:V180	3.53	No	No	0	3	5
129	R:R:F186	R:R:V180	13.11	No	No	0	4	5
130	R:R:F189	R:R:I187	7.54	Yes	Yes	0	8	7
131	R:R:I187	R:R:L190	8.56	Yes	No	0	7	5
132	R:R:F189	R:R:V195	5.24	Yes	No	0	8	8
133	R:R:N192	R:R:P193	6.52	Yes	No	0	7	5
134	R:R:A194	R:R:N192	4.69	No	Yes	0	5	7
135	R:R:N192	R:R:V195	7.39	Yes	No	0	7	8
136	R:R:P193	R:R:T424	3.5	No	No	0	5	7
137	R:R:T196	R:R:T424	4.71	No	No	0	8	7
138	R:R:F197	R:R:L421	4.87	No	No	0	7	7
139	R:R:F197	R:R:F425	4.29	No	No	0	7	6
140	L:L:?1	R:R:T199	3.9	Yes	No	1	0	9
141	R:R:I201	R:R:Y205	6.04	No	Yes	0	7	8
142	R:R:F204	R:R:Y205	10.32	Yes	Yes	0	9	8
143	R:R:F204	R:R:V208	5.24	Yes	No	0	9	8
144	R:R:F204	R:R:W413	10.02	Yes	Yes	0	9	9
145	R:R:F204	R:R:T414	5.19	Yes	Yes	0	9	7
146	R:R:F204	R:R:N417	14.5	Yes	No	0	9	9
147	R:R:L421	R:R:Y205	5.86	No	Yes	0	7	8
148	R:R:I218	R:R:Y215	4.84	No	Yes	0	9	9
149	R:R:I402	R:R:Y215	8.46	No	Yes	0	9	9
150	R:R:L406	R:R:Y215	4.69	No	Yes	0	8	9
151	R:R:S219	R:R:T399	6.4	No	No	0	8	9
152	R:R:S222	R:R:V398	9.7	No	No	0	9	9
153	R:R:E395	R:R:R223	12.79	No	No	0	9	7
154	R:R:R394	R:R:S224	6.59	No	No	0	7	6
155	R:R:A392	R:R:E395	4.53	No	No	0	5	9
156	R:R:R396	R:R:R400	9.6	No	No	0	7	7
157	R:R:I405	R:R:Y453	7.25	No	Yes	0	9	9
158	R:R:F409	R:R:W413	6.01	Yes	Yes	1	9	9
159	R:R:F409	R:R:N445	7.25	Yes	Yes	1	9	9
160	R:R:I410	R:R:T414	6.08	No	Yes	0	8	7
161	R:R:N445	R:R:T412	7.31	Yes	No	0	9	9
162	R:R:C442	R:R:W413	6.53	No	Yes	0	9	9
163	R:R:N445	R:R:W413	7.91	Yes	Yes	1	9	9
164	L:L:?1	R:R:W413	6.77	Yes	Yes	1	0	9
165	R:R:P415	R:R:T414	3.5	No	Yes	0	9	7
166	R:R:N417	R:R:Y416	4.65	No	Yes	1	9	9
167	R:R:V420	R:R:Y416	8.83	No	Yes	1	8	9
168	R:R:W435	R:R:Y416	3.86	Yes	Yes	1	6	9
169	R:R:Y416	R:R:Y439	9.93	Yes	Yes	1	9	7
170	R:R:C442	R:R:Y416	4.03	No	Yes	0	9	9
171	L:L:?1	R:R:Y416	19.36	Yes	Yes	1	0	9
172	L:L:?1	R:R:N417	6.35	Yes	No	1	0	9
173	R:R:I430	R:R:M419	4.37	Yes	No	0	6	7
174	L:L:?1	R:R:V420	3.94	Yes	No	1	0	8
175	R:R:I430	R:R:N423	4.25	Yes	No	1	6	5
176	R:R:N423	R:R:W435	5.65	No	Yes	1	5	6
177	R:R:F425	R:R:T424	5.19	No	No	0	6	7
178	R:R:C426	R:R:C429	7.28	No	No	0	7	7
179	R:R:I430	R:R:W435	8.22	Yes	Yes	1	6	6
180	R:R:P431	R:R:T433	3.5	No	No	0	6	4
181	R:R:P431	R:R:V434	5.3	No	No	0	6	5
182	R:R:W435	R:R:Y439	3.86	Yes	Yes	1	6	7
183	L:L:?1	R:R:Y439	6.97	Yes	Yes	1	0	7
184	L:L:?1	R:R:Y443	5.42	Yes	Yes	1	0	9
185	R:R:N445	R:R:N449	10.9	Yes	No	1	9	9
186	R:R:A454	R:R:F460	4.16	No	Yes	0	9	9
187	R:R:F464	R:R:L455	7.31	No	No	0	9	8
188	R:R:N457	R:R:T459	4.39	No	No	0	9	8
189	R:R:F460	R:R:N457	3.62	Yes	No	0	9	9
190	R:R:K462	R:R:R465	9.9	No	No	0	6	6
191	R:R:G438	R:R:M419	3.49	No	No	0	7	7
192	R:R:I430	R:R:P431	3.39	Yes	No	0	6	6
193	R:R:L206	R:R:P207	3.28	No	No	0	8	9
194	R:R:H217	R:R:Y131	3.27	No	Yes	0	7	9
195	R:R:C76	R:R:M54	3.24	No	Yes	0	8	8
196	R:R:A75	R:R:M54	3.22	No	Yes	0	9	8
197	R:R:T447	R:R:V444	3.17	Yes	No	0	8	6
198	R:R:P181	R:R:Q184	3.16	No	No	0	3	5
199	R:R:T39	R:R:T90	3.14	No	No	0	7	8
200	R:R:T447	R:R:T46	3.14	Yes	Yes	0	8	8
201	R:R:I402	R:R:S219	3.1	No	No	0	9	8
202	R:R:M86	R:R:S43	3.07	No	No	0	9	8
203	R:R:I81	R:R:V115	3.07	Yes	No	0	9	8
204	R:R:M211	R:R:S127	3.07	No	No	0	9	9
205	R:R:I430	R:R:V422	3.07	Yes	No	0	6	7
206	R:R:M32	R:R:V33	3.04	No	No	0	6	6
207	R:R:I448	R:R:T447	3.04	No	Yes	0	7	8
208	R:R:K136	R:R:T139	3	No	No	0	7	7
209	R:R:K397	R:R:T401	3	No	No	0	9	9
210	R:R:L44	R:R:V47	2.98	No	No	0	5	7
211	R:R:L44	R:R:V48	2.98	No	No	0	5	5
212	R:R:L79	R:R:V47	2.98	No	No	0	9	7
213	R:R:L55	R:R:V59	2.98	No	No	0	6	7
214	R:R:L406	R:R:T212	2.95	No	No	0	8	7
215	R:R:I125	R:R:M152	2.92	Yes	No	0	8	8
216	R:R:E28	R:R:V30	2.85	No	No	0	5	4
217	R:R:L79	R:R:M54	2.83	No	Yes	0	9	8
218	R:R:A149	R:R:F70	2.77	No	Yes	0	8	8
219	R:R:A167	R:R:F189	2.77	No	Yes	0	8	8
220	R:R:H217	R:R:V213	2.77	No	No	0	7	5
221	R:R:L407	R:R:L411	2.77	No	No	0	8	5
222	R:R:C452	R:R:Y453	2.69	No	Yes	0	9	9
223	R:R:A200	R:R:Y205	2.67	No	Yes	0	8	8
224	R:R:F464	R:R:S56	2.64	No	No	0	9	9
225	R:R:R225	R:R:V226	2.62	No	No	0	8	6
226	R:R:A77	R:R:W157	2.59	No	Yes	0	9	9
227	R:R:F403	R:R:T399	2.59	No	No	0	8	9
228	R:R:F170	R:R:L169	2.44	No	Yes	0	7	6
229	R:R:L220	R:R:R223	2.43	No	No	0	4	7
230	R:R:I57	R:R:Y69	2.42	No	No	0	9	7
231	L:L:?1	R:R:G203	2.26	Yes	No	0	0	9
232	R:R:G49	R:R:P450	2.03	No	Yes	0	9	9
233	R:R:A149	R:R:G150	1.95	No	No	0	8	5
234	R:R:A165	R:R:P166	1.87	No	No	0	7	9
235	R:R:G40	R:R:S43	1.86	No	No	0	6	8
236	R:R:G101	R:R:V104	1.84	No	No	0	8	6
237	R:R:A408	R:R:C452	1.81	No	No	0	8	9
238	R:R:P450	R:R:V53	1.77	Yes	No	0	9	9
239	R:R:G438	R:R:I437	1.76	No	No	0	7	5
240	R:R:G96	R:R:K95	1.74	No	No	0	7	5
241	R:R:G176	R:R:K177	1.74	No	No	0	4	3
242	R:R:A77	R:R:S119	1.71	No	No	0	9	9
243	R:R:A392	R:R:S224	1.71	No	No	0	5	6
244	R:R:C426	R:R:V422	1.71	No	No	0	7	7
245	R:R:A165	R:R:V114	1.7	No	No	0	7	8
246	R:R:A221	R:R:V134	1.7	No	No	0	8	9
247	R:R:C456	R:R:T401	1.69	No	No	0	8	9
248	R:R:K136	R:R:P137	1.67	No	No	0	7	9
249	R:R:L138	R:R:P137	1.64	No	No	0	7	9
250	R:R:L441	R:R:P415	1.64	No	No	0	9	9
251	R:R:L455	R:R:P450	1.64	No	Yes	0	8	9
252	R:R:S160	R:R:V114	1.62	No	No	0	9	8
253	R:R:A156	R:R:I125	1.62	No	Yes	0	9	8
254	R:R:V174	R:R:V175	1.6	No	No	0	5	5
255	R:R:T37	R:R:V33	1.59	No	No	0	5	6
256	R:R:T37	R:R:V38	1.59	No	No	0	5	5
257	R:R:T447	R:R:V45	1.59	Yes	No	0	8	5
258	R:R:T146	R:R:V66	1.59	No	No	0	6	8
259	R:R:T414	R:R:V418	1.59	Yes	No	0	7	7
260	R:R:A202	R:R:L163	1.58	No	No	0	7	8
261	R:R:I437	R:R:S436	1.55	No	No	0	5	6
262	R:R:I402	R:R:V398	1.54	No	No	0	9	9
263	R:R:I405	R:R:T401	1.52	No	No	0	9	9
264	R:R:M148	R:R:T145	1.51	No	No	0	8	9
265	R:R:F197	R:R:G198	1.51	No	No	0	7	7
266	R:R:K147	R:R:T145	1.5	No	No	0	6	9
267	R:R:N192	R:R:S191	1.49	Yes	No	0	7	7
268	R:R:I35	R:R:I93	1.47	No	No	0	7	7
269	R:R:L42	R:R:T447	1.47	No	Yes	0	6	8
270	R:R:I410	R:R:L411	1.43	No	No	0	8	5
271	R:R:L159	R:R:M121	1.41	No	No	0	6	8
272	R:R:K461	R:R:L455	1.41	No	No	0	9	8
273	R:R:A83	R:R:F84	1.39	No	No	0	5	6
274	R:R:A393	R:R:R396	1.38	No	No	0	6	7
275	R:R:E31	R:R:I35	1.37	No	No	0	6	7
276	R:R:K58	R:R:Q64	1.36	No	No	0	5	8
277	R:R:N183	R:R:Y97	1.16	No	No	0	4	5
278	R:R:E31	R:R:Y27	1.12	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T46	4.425	4	0	8
2	R:R:M54	4.5	4	0	8
3	R:R:N68	5.1275	4	0	9
4	R:R:F70	5.982	5	0	8
5	R:R:D78	9.62	4	1	9
6	R:R:I81	4.77	4	1	9
7	R:R:Y89	5.3925	4	1	8
8	R:R:W98	7.554	5	2	9
9	R:R:P99	5.222	5	2	5
10	R:R:I125	4.0825	4	0	8
11	R:R:D129	8.8875	4	3	9
12	R:R:Y131	8.455	4	0	9
13	R:R:Y140	12.095	4	0	9
14	R:R:R144	11.214	5	3	9
15	R:R:W157	5.2675	4	5	9
16	R:R:W164	12.202	5	1	8
17	R:R:L169	4.865	4	0	6
18	R:R:I187	7.27	4	0	7
19	R:R:F189	6.6425	4	0	8
20	R:R:N192	5.0225	4	0	7
21	R:R:F204	9.054	5	0	9
22	R:R:Y205	6.2225	4	0	8
23	R:R:Y215	6.262	5	0	9
24	R:R:F409	5.515	4	1	9
25	R:R:W413	6.72571	7	1	9
26	R:R:T414	4.09	4	0	7
27	R:R:Y416	8.44333	6	1	9
28	R:R:I430	4.66	5	1	6
29	R:R:W435	5.3975	4	1	6
30	R:R:Y439	6.9275	4	1	7
31	R:R:Y443	6.078	5	1	9
32	R:R:N445	8.3425	4	1	9
33	R:R:T447	2.482	5	0	8
34	R:R:P450	3.3975	4	0	9
35	R:R:Y453	6.03667	6	4	9
36	R:R:F460	6.5025	4	0	9
37	L:L:?1	8.43583	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E31	R:R:I35	10.89	1.37	No	No	0	6	7
2	R:R:I35	R:R:I94	16.2328	4.42	No	No	0	7	7
3	R:R:I94	R:R:M32	13.5689	4.37	No	No	0	7	6
4	R:R:M32	R:R:V33	10.89	3.04	No	No	0	6	6
5	R:R:I35	R:R:I93	29.1433	1.47	No	No	0	7	7
6	R:R:I93	R:R:Y89	31.4742	4.84	No	Yes	1	7	8
7	R:R:Y439	R:R:Y89	72.8621	6.95	Yes	Yes	1	7	8
8	L:L:?1	R:R:Y439	76.7595	6.97	Yes	Yes	1	0	7
9	L:L:?1	R:R:Y443	43.1209	5.42	Yes	Yes	1	0	9
10	R:R:M86	R:R:Y443	18.6393	7.18	No	Yes	0	9	9
11	R:R:M86	R:R:T46	13.2814	4.52	No	Yes	0	9	8
12	R:R:I81	R:R:Y443	21.4999	3.63	Yes	Yes	1	9	9
13	R:R:I81	R:R:S446	17.7085	4.64	Yes	No	0	9	9
14	R:R:A75	R:R:N50	22.0297	4.69	No	No	0	9	9
15	R:R:D78	R:R:N50	48.214	13.46	Yes	No	0	9	9
16	R:R:D78	R:R:S446	25.3216	8.83	Yes	No	0	9	9
17	R:R:D78	R:R:N449	24.9811	12.12	Yes	No	1	9	9
18	R:R:N445	R:R:N449	27.1227	10.9	Yes	No	1	9	9
19	R:R:N445	R:R:W413	27.1833	7.91	Yes	Yes	1	9	9
20	L:L:?1	R:R:W413	94.1804	6.77	Yes	Yes	1	0	9
21	R:R:N50	R:R:P450	24.7162	8.15	No	Yes	0	9	9
22	R:R:L455	R:R:P450	16.6112	1.64	No	Yes	0	8	9
23	R:R:F464	R:R:L455	11.1321	7.31	No	No	0	9	8
24	R:R:A75	R:R:M54	19.328	3.22	No	Yes	0	9	8
25	R:R:F409	R:R:W413	76.6309	6.01	Yes	Yes	1	9	9
26	R:R:F409	R:R:L123	81.5801	4.87	Yes	No	0	9	9
27	R:R:L123	R:R:Y453	100	10.55	No	Yes	0	9	9
28	R:R:L71	R:R:Y453	32.1629	3.52	No	Yes	0	8	9
29	R:R:L71	R:R:N68	30.3163	4.12	No	Yes	0	8	9
30	R:R:I57	R:R:N68	10.5494	4.25	No	Yes	0	9	9
31	R:R:F460	R:R:N68	16.4901	4.83	Yes	Yes	0	9	9
32	R:R:I126	R:R:Y453	51.2033	6.04	No	Yes	4	9	9
33	R:R:F70	R:R:I126	55.1007	3.77	Yes	No	0	8	9
34	R:R:D129	R:R:F70	35.8483	9.55	Yes	Yes	0	9	8
35	R:R:D129	R:R:R144	21.8253	11.91	Yes	Yes	3	9	9
36	R:R:F70	R:R:I125	18.9647	7.54	Yes	Yes	0	8	8
37	R:R:I125	R:R:N122	12.797	4.25	Yes	No	0	8	9
38	R:R:L123	R:R:L74	25.5033	5.54	No	No	0	9	9
39	R:R:I81	R:R:V115	11.4197	3.07	Yes	No	0	9	8
40	R:R:Y416	R:R:Y439	11.9267	9.93	Yes	Yes	1	9	7
41	R:R:N417	R:R:Y416	16.8912	4.65	No	Yes	1	9	9
42	R:R:F204	R:R:N417	42.8334	14.5	Yes	No	0	9	9
43	R:R:F204	R:R:Y205	91.3728	10.32	Yes	Yes	0	9	8
44	R:R:L421	R:R:Y205	85.2505	5.86	No	Yes	0	7	8
45	R:R:F197	R:R:L421	83.3132	4.87	No	No	0	7	7
46	R:R:F197	R:R:F425	79.1509	4.29	No	No	0	7	6
47	R:R:F425	R:R:T424	77.0471	5.19	No	No	0	6	7
48	R:R:P193	R:R:T424	72.794	3.5	No	No	0	5	7
49	R:R:N192	R:R:P193	70.6448	6.52	Yes	No	0	7	5
50	R:R:N192	R:R:V195	64.1062	7.39	Yes	No	0	7	8
51	R:R:F189	R:R:V195	61.8965	5.24	Yes	No	0	8	8
52	R:R:F189	R:R:I187	14.8479	7.54	Yes	Yes	0	8	7
53	L:L:?1	R:R:N417	26.5779	6.35	Yes	No	1	0	9
54	R:R:F204	R:R:W413	67.6479	10.02	Yes	Yes	0	9	9
55	R:R:Y89	R:R:Y92	34.524	4.96	Yes	No	0	8	8
56	R:R:W98	R:R:Y92	31.9585	5.79	Yes	No	0	9	8
57	R:R:P99	R:R:W98	16.1117	5.4	Yes	Yes	2	5	9
58	R:R:Q172	R:R:R178	15.1884	11.68	No	No	0	7	5
59	R:R:Q172	R:R:Q188	32.458	7.68	No	No	0	7	8
60	R:R:Q188	R:R:W171	37.2559	12.05	No	No	0	8	7
61	R:R:F189	R:R:W171	44.3393	11.02	Yes	No	0	8	7
62	R:R:F170	R:R:L169	10.3148	2.44	No	Yes	0	7	6
63	R:R:F170	R:R:F173	12.8576	4.29	No	No	0	7	6
64	R:R:F173	R:R:Q172	15.3852	17.57	No	No	0	6	7
65	L:L:?1	R:R:W164	25.9119	24.08	Yes	Yes	1	0	8
66	R:R:N117	R:R:W164	19.3053	7.91	No	Yes	0	9	8
67	R:R:N117	R:R:S160	12.1765	8.94	No	No	0	9	9
68	R:R:V120	R:R:W413	23.8535	6.13	No	Yes	1	9	9
69	R:R:P207	R:R:V120	28.3487	3.53	No	No	0	9	9
70	R:R:L124	R:R:P207	24.3681	4.93	No	No	0	8	9
71	R:R:F128	R:R:L124	20.1907	3.65	No	No	6	7	8
72	R:R:R130	R:R:Y453	24.6178	6.17	No	Yes	4	9	9
73	R:R:R130	R:R:Y215	28.1368	8.23	No	Yes	0	9	9
74	R:R:F128	R:R:L214	19.0177	8.53	No	No	0	7	8
75	R:R:C133	R:R:D129	10.837	4.67	No	Yes	0	9	9
76	R:R:L214	R:R:Y131	17.5344	9.38	No	Yes	0	8	9
77	R:R:F132	R:R:Y131	13.9927	6.19	No	Yes	0	7	9
78	R:R:F132	R:R:K136	10.8294	4.96	No	No	0	7	7
79	R:R:F132	R:R:Y140	13.8792	17.54	No	Yes	0	7	9
80	R:R:R178	R:R:V180	10.3148	3.92	No	No	0	5	5
81	R:R:F204	R:R:T414	17.8977	5.19	Yes	Yes	0	9	7
82	R:R:I402	R:R:Y215	12.2673	8.46	No	Yes	0	9	9
83	R:R:C442	R:R:Y416	12.2143	4.03	No	Yes	0	9	9
84	R:R:W435	R:R:Y439	19.3583	3.86	Yes	Yes	1	6	7
85	R:R:I430	R:R:W435	44.1955	8.22	Yes	Yes	1	6	6
86	R:R:I430	R:R:M419	16.3085	4.37	Yes	No	0	6	7
87	R:R:I430	R:R:V422	12.2522	3.07	Yes	No	0	6	7
88	R:R:I430	R:R:P431	12.2522	3.39	Yes	No	0	6	6
89	R:R:G438	R:R:M419	12.2522	3.49	No	No	0	7	7
90	R:R:T447	R:R:T46	11.7981	3.14	Yes	Yes	0	8	8
91	R:R:L79	R:R:M54	11.1321	2.83	No	Yes	0	9	8
92	R:R:D78	R:R:L74	23.4827	4.07	Yes	No	1	9	9
93	R:R:C442	R:R:W413	13.0922	6.53	No	Yes	0	9	9
94	L:L:?1	R:R:Y416	17.8901	19.36	Yes	Yes	1	0	9
95	R:R:W435	R:R:Y416	32.2612	3.86	Yes	Yes	1	6	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I81	R:R:S85	7.74	1	Yes	No	9	9	2	2
R:R:I81	R:R:Y443	3.63	1	Yes	Yes	9	9	2	1
R:R:D112	R:R:S85	10.31	1	No	No	9	9	1	2
R:R:S85	R:R:Y443	3.82	1	No	Yes	9	9	2	1
R:R:M86	R:R:Y443	7.18	0	No	Yes	9	9	2	1
R:R:Y439	R:R:Y89	6.95	1	Yes	Yes	7	8	1	2
R:R:D112	R:R:Y443	10.34	1	No	Yes	9	9	1	1
L:L:?1	R:R:D112	8.07	1	Yes	No	0	9	0	1
R:R:C113	R:R:W164	9.14	1	No	Yes	9	8	1	1
L:L:?1	R:R:C113	4.19	1	Yes	No	0	9	0	1
R:R:S116	R:R:W413	3.71	1	No	Yes	8	9	1	1
L:L:?1	R:R:S116	9.92	1	Yes	No	0	8	0	1
R:R:N117	R:R:W164	7.91	0	No	Yes	9	8	2	1
R:R:F409	R:R:V120	3.93	1	Yes	No	9	9	2	2
R:R:V120	R:R:W413	6.13	1	No	Yes	9	9	2	1
R:R:L163	R:R:W164	11.39	0	No	Yes	8	8	2	1
R:R:T199	R:R:W164	8.49	1	No	Yes	9	8	1	1
L:L:?1	R:R:W164	24.08	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T199	3.9	1	Yes	No	0	9	0	1
R:R:F204	R:R:W413	10.02	0	Yes	Yes	9	9	2	1
R:R:F204	R:R:N417	14.5	0	Yes	No	9	9	2	1
R:R:F409	R:R:W413	6.01	1	Yes	Yes	9	9	2	1
R:R:F409	R:R:N445	7.25	1	Yes	Yes	9	9	2	2
R:R:C442	R:R:W413	6.53	0	No	Yes	9	9	2	1
R:R:N445	R:R:W413	7.91	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:W413	6.77	1	Yes	Yes	0	9	0	1
R:R:N417	R:R:Y416	4.65	1	No	Yes	9	9	1	1
R:R:V420	R:R:Y416	8.83	1	No	Yes	8	9	1	1
R:R:W435	R:R:Y416	3.86	1	Yes	Yes	6	9	2	1
R:R:Y416	R:R:Y439	9.93	1	Yes	Yes	9	7	1	1
R:R:C442	R:R:Y416	4.03	0	No	Yes	9	9	2	1
L:L:?1	R:R:Y416	19.36	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:N417	6.35	1	Yes	No	0	9	0	1
L:L:?1	R:R:V420	3.94	1	Yes	No	0	8	0	1
R:R:W435	R:R:Y439	3.86	1	Yes	Yes	6	7	2	1
L:L:?1	R:R:Y439	6.97	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y443	5.42	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:G203	2.26	1	Yes	No	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8E9X_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	255
Number of Links	278
Number of Hubs	37
Number of Links mediated by Hubs	148
Number of Communities	6
Number of Nodes involved in Communities	45
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	40478
Length Of Smallest Path	3
Average Path Length	12.7614
Length of Longest Path	29
Minimum Path Strength	1.245
Average Path Strength	6.63928
Maximum Path Strength	21.72
Minimum Path Correlation	0.7
Average Path Correlation	0.923555
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	51.2567
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8134
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WEC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WEC
Name	11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Synonyms
Identifier
Formula	C18 H20 N4
Molecular Weight	292.378
SMILES
PubChem	16103
Formal Charge	0
Total Atoms	42
Total Chiral Atoms	0
Total Bonds	45
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>8E9X_nogp_Chain_R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G Y W P L G A V V C D L W L A L D C V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F I Q F L S N P A V T F G T A I A G F Y L P V V I M T V L Y I H I S L A S R S R V A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F K K T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275	Gi1/β1/γ2	3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275		3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	doi.org/10.1038/nature17188
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	6KP6	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	-	3	2020-03-11	doi.org/10.1107/S2052252520000597
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	9M4Q	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	doi.org/10.1038/nature25758
	9IQS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	Muscarinic toxin 3	-	3.6	2025-07-23	To be published

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Download 8E9X_nogp.zip

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