psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N87	R:R:S43	5.96	No	No	0	9	8
2	R:R:M86	R:R:T46	4.52	No	No	0	9	8
3	R:R:T447	R:R:T46	10.99	No	No	0	8	8
4	R:R:D78	R:R:N50	8.08	Yes	No	4	9	9
5	R:R:N50	R:R:P450	6.52	No	No	4	9	9
6	R:R:I51	R:R:M54	4.37	No	No	0	7	8
7	R:R:F464	R:R:L52	9.74	Yes	No	0	9	8
8	R:R:F464	R:R:V53	3.93	Yes	No	0	9	9
9	R:R:S56	R:R:T463	7.99	No	No	0	9	9
10	R:R:F464	R:R:S56	3.96	Yes	No	0	9	9
11	R:R:I57	R:R:N68	4.25	No	No	0	9	9
12	R:R:F72	R:R:I57	6.28	No	No	0	8	9
13	R:R:N60	R:R:Q62	11.88	No	No	0	8	6
14	R:R:L63	R:R:N60	9.61	No	No	0	9	8
15	R:R:N60	R:R:T463	7.31	No	No	0	8	9
16	R:R:Q62	R:R:T459	11.34	No	No	0	6	8
17	R:R:L63	R:R:N68	4.12	No	No	0	9	9
18	R:R:F460	R:R:L63	7.31	No	No	0	9	9
19	R:R:N68	R:R:T65	5.85	No	No	0	9	8
20	R:R:V66	R:R:Y69	5.05	No	No	0	8	7
21	R:R:R144	R:R:V66	7.85	Yes	No	0	9	8
22	R:R:D129	R:R:N67	6.73	Yes	No	3	9	9
23	R:R:N67	R:R:R144	10.85	No	Yes	3	9	9
24	R:R:F70	R:R:I125	3.77	No	No	0	8	8
25	R:R:F70	R:R:I126	5.02	No	No	0	8	9
26	R:R:F70	R:R:I153	10.05	No	No	0	8	9
27	R:R:L71	R:R:Y453	5.86	No	No	0	8	9
28	R:R:N122	R:R:S73	5.96	No	No	0	9	9
29	R:R:I153	R:R:S73	6.19	No	No	0	9	9
30	R:R:S73	R:R:W157	6.18	No	Yes	0	9	9
31	R:R:D78	R:R:L74	4.07	Yes	No	0	9	9
32	R:R:D78	R:R:S446	4.42	Yes	No	0	9	9
33	R:R:D78	R:R:P450	6.44	Yes	No	4	9	9
34	R:R:F84	R:R:I80	6.28	No	No	0	6	8
35	R:R:I80	R:R:V115	4.61	No	Yes	0	8	8
36	R:R:I81	R:R:V115	4.61	No	Yes	0	9	8
37	R:R:I81	R:R:S446	4.64	No	No	0	9	9
38	R:R:A83	R:R:F84	4.16	No	No	0	5	6
39	R:R:S85	R:R:W108	4.94	No	Yes	2	9	7
40	R:R:D112	R:R:S85	10.31	Yes	No	2	9	9
41	R:R:S85	R:R:Y443	7.63	No	Yes	2	9	9
42	R:R:M86	R:R:Y443	10.78	No	Yes	0	9	9
43	R:R:L88	R:R:W98	7.97	No	Yes	0	7	9
44	R:R:L88	R:R:W108	21.64	No	Yes	0	7	7
45	R:R:I93	R:R:Y89	10.88	Yes	Yes	0	7	8
46	R:R:W108	R:R:Y89	3.86	Yes	Yes	2	7	8
47	R:R:Y439	R:R:Y89	20.85	Yes	Yes	2	7	8
48	R:R:W440	R:R:Y89	9.65	No	Yes	0	9	8
49	R:R:I93	R:R:Y92	6.04	Yes	No	0	7	8
50	R:R:W98	R:R:Y92	4.82	Yes	No	0	9	8
51	R:R:C185	R:R:Y92	4.03	No	No	0	9	8
52	R:R:I93	R:R:S436	6.19	Yes	No	0	7	6
53	R:R:P99	R:R:Y97	4.17	No	No	0	5	5
54	R:R:N183	R:R:Y97	4.65	No	No	0	4	5
55	R:R:P99	R:R:W98	5.4	No	Yes	0	5	9
56	R:R:L100	R:R:W98	12.53	No	Yes	0	7	9
57	R:R:V104	R:R:W98	8.58	No	Yes	0	6	9
58	R:R:A102	R:R:R178	4.15	No	No	0	4	5
59	R:R:A102	R:R:D182	4.63	No	No	0	4	3
60	R:R:C105	R:R:C185	7.28	No	No	0	9	9
61	R:R:W108	R:R:Y439	6.75	Yes	Yes	2	7	7
62	R:R:A110	R:R:L169	4.73	No	No	0	8	6
63	R:R:D112	R:R:Y113	5.75	Yes	Yes	0	9	9
64	R:R:D112	R:R:Y439	5.75	Yes	Yes	2	9	7
65	R:R:D112	R:R:Y443	5.75	Yes	Yes	2	9	9
66	R:R:I187	R:R:Y113	7.25	No	Yes	0	7	9
67	R:R:Y113	R:R:Y416	3.97	Yes	Yes	0	9	9
68	R:R:V115	R:R:W157	4.9	Yes	Yes	0	8	9
69	R:R:M121	R:R:N117	9.82	No	Yes	0	8	9
70	R:R:N117	R:R:S160	4.47	Yes	No	0	9	9
71	R:R:N117	R:R:W164	12.43	Yes	No	0	9	8
72	R:R:A118	R:R:W157	7.78	No	Yes	0	9	9
73	R:R:I126	R:R:N122	4.25	No	No	0	9	9
74	R:R:L123	R:R:N449	4.12	No	No	0	9	9
75	R:R:L123	R:R:Y453	5.86	No	No	0	9	9
76	R:R:F128	R:R:L124	7.31	Yes	No	0	7	8
77	R:R:F128	R:R:I125	3.77	Yes	No	0	7	8
78	R:R:I125	R:R:M152	7.29	No	No	0	8	8
79	R:R:I126	R:R:R130	6.26	No	No	0	9	9
80	R:R:L214	R:R:S127	6.01	No	No	0	8	9
81	R:R:S127	R:R:Y215	8.9	No	Yes	0	9	9
82	R:R:F128	R:R:I210	3.77	Yes	No	0	7	8
83	R:R:F128	R:R:L214	6.09	Yes	No	0	7	8
84	R:R:C133	R:R:D129	4.67	No	Yes	3	9	9
85	R:R:D129	R:R:Y140	12.64	Yes	Yes	3	9	9
86	R:R:D129	R:R:R144	9.53	Yes	Yes	3	9	9
87	R:R:R130	R:R:Y453	9.26	No	No	0	9	9
88	R:R:F132	R:R:Y131	5.16	No	Yes	0	7	9
89	R:R:T135	R:R:Y131	9.99	No	Yes	0	9	9
90	R:R:L214	R:R:Y131	4.69	No	Yes	0	8	9
91	R:R:H217	R:R:Y131	6.53	No	Yes	0	7	9
92	R:R:F132	R:R:K136	12.41	No	Yes	0	7	7
93	R:R:F132	R:R:Y140	14.44	No	Yes	0	7	9
94	R:R:C133	R:R:Y140	4.03	No	Yes	3	9	9
95	R:R:I218	R:R:V134	4.61	No	No	0	9	9
96	R:R:K136	R:R:T135	4.5	Yes	No	0	7	9
97	R:R:K136	R:R:T139	4.5	Yes	No	6	7	7
98	R:R:K136	R:R:R143	4.95	Yes	No	6	7	6
99	R:R:R143	R:R:T139	7.76	No	No	6	6	7
100	R:R:P141	R:R:Y140	5.56	No	Yes	0	7	9
101	R:R:R144	R:R:Y140	11.32	Yes	Yes	3	9	9
102	R:R:A149	R:R:R144	4.15	No	Yes	0	8	9
103	R:R:L151	R:R:M148	5.65	No	No	0	3	8
104	R:R:L159	R:R:L163	4.15	No	No	0	6	8
105	R:R:L163	R:R:W164	17.08	No	No	0	8	8
106	R:R:T199	R:R:W164	10.92	No	No	0	9	8
107	R:R:F189	R:R:W171	8.02	Yes	No	7	8	7
108	R:R:V195	R:R:W171	4.9	No	No	7	8	7
109	R:R:Q172	R:R:Q188	19.2	No	Yes	8	7	8
110	R:R:R178	R:R:V180	7.85	No	No	0	5	5
111	R:R:Q188	R:R:T179	4.25	Yes	No	0	8	5
112	R:R:F186	R:R:V180	11.8	No	No	0	4	5
113	R:R:Q188	R:R:V180	4.3	Yes	No	0	8	5
114	R:R:N183	R:R:P181	4.89	No	No	5	4	3
115	R:R:P181	R:R:Q184	14.21	No	No	5	3	5
116	R:R:N183	R:R:Q184	18.49	No	No	5	4	5
117	R:R:F186	R:R:Q184	4.68	No	No	0	4	5
118	R:R:F189	R:R:I187	5.02	Yes	No	0	8	7
119	R:R:I187	R:R:L190	8.56	No	No	0	7	5
120	R:R:F189	R:R:V195	9.18	Yes	No	7	8	8
121	R:R:F189	R:R:T199	9.08	Yes	No	0	8	9
122	R:R:N192	R:R:P193	4.89	No	No	0	7	5
123	R:R:N192	R:R:V195	7.39	No	No	0	7	8
124	R:R:F197	R:R:I201	8.79	No	Yes	0	7	7
125	R:R:I201	R:R:Y205	4.84	Yes	No	0	7	8
126	R:R:F204	R:R:Y205	16.5	Yes	No	0	9	8
127	R:R:F204	R:R:V208	5.24	Yes	No	0	9	8
128	R:R:F204	R:R:T414	3.89	Yes	No	0	9	7
129	R:R:F204	R:R:N417	22.96	Yes	No	0	9	9
130	R:R:F409	R:R:V208	3.93	No	No	0	9	8
131	R:R:M211	R:R:Y215	4.79	No	Yes	0	9	9
132	R:R:I405	R:R:Y215	4.84	No	Yes	0	9	9
133	R:R:L406	R:R:Y215	7.03	No	Yes	0	8	9
134	R:R:E395	R:R:S219	4.31	Yes	No	0	9	8
135	R:R:E395	R:R:S222	5.75	Yes	No	0	9	9
136	R:R:S222	R:R:V398	6.46	No	No	0	9	9
137	R:R:E395	R:R:T399	4.23	Yes	No	0	9	9
138	R:R:K397	R:R:T401	6.01	No	Yes	0	9	9
139	R:R:F403	R:R:L407	7.31	No	No	0	8	8
140	R:R:I410	R:R:L406	4.28	No	No	0	8	8
141	R:R:I410	R:R:L407	4.28	No	No	0	8	8
142	R:R:F409	R:R:W413	13.03	No	Yes	9	9	9
143	R:R:F409	R:R:N445	6.04	No	Yes	9	9	9
144	R:R:N445	R:R:T412	11.7	Yes	No	0	9	9
145	R:R:N417	R:R:W413	5.65	No	Yes	0	9	9
146	R:R:C442	R:R:W413	15.67	No	Yes	0	9	9
147	R:R:N445	R:R:W413	9.04	Yes	Yes	9	9	9
148	R:R:P415	R:R:T414	5.25	No	No	0	9	7
149	R:R:L441	R:R:P415	4.93	No	No	0	9	9
150	R:R:N417	R:R:Y416	4.65	No	Yes	0	9	9
151	R:R:V420	R:R:Y416	7.57	No	Yes	0	8	9
152	R:R:W435	R:R:Y416	6.75	No	Yes	0	6	9
153	R:R:C442	R:R:Y416	6.72	No	Yes	0	9	9
154	R:R:M419	R:R:N423	11.22	Yes	No	1	7	5
155	R:R:I430	R:R:M419	4.37	Yes	Yes	1	6	7
156	R:R:M419	R:R:V434	6.09	Yes	No	1	7	5
157	R:R:M419	R:R:W435	5.82	Yes	No	1	7	6
158	R:R:I430	R:R:N423	4.25	Yes	No	1	6	5
159	R:R:N423	R:R:W435	4.52	No	No	1	5	6
160	R:R:F425	R:R:T424	7.78	No	No	0	6	7
161	R:R:C426	R:R:C429	7.28	No	No	1	7	7
162	R:R:I430	R:R:P431	5.08	Yes	No	1	6	6
163	R:R:I430	R:R:V434	9.22	Yes	No	1	6	5
164	R:R:P431	R:R:V434	5.3	No	No	1	6	5
165	R:R:Y439	R:R:Y443	13.9	Yes	Yes	2	7	9
166	R:R:N445	R:R:N449	6.81	Yes	No	0	9	9
167	R:R:C452	R:R:I448	4.91	No	No	0	9	7
168	R:R:A454	R:R:F464	4.16	No	Yes	0	9	9
169	R:R:N457	R:R:T459	5.85	No	No	0	9	8
170	R:R:F460	R:R:N457	8.46	No	No	0	9	9
171	R:R:L468	R:R:R465	4.86	No	No	0	8	6
172	R:R:S116	R:R:W413	3.71	No	Yes	0	8	9
173	R:R:V91	R:R:W98	3.68	No	Yes	0	8	9
174	R:R:V120	R:R:W413	3.68	No	Yes	0	9	9
175	R:R:V174	R:R:W171	3.68	No	No	0	5	7
176	R:R:F460	R:R:L71	3.65	No	No	0	9	8
177	R:R:I218	R:R:Y131	3.63	No	Yes	0	9	9
178	R:R:G82	R:R:I81	3.53	No	No	0	9	9
179	R:R:P207	R:R:V120	3.53	No	No	0	9	9
180	R:R:G150	R:R:I153	3.53	No	No	0	5	9
181	R:R:L421	R:R:Y205	3.52	No	No	0	7	8
182	R:R:L206	R:R:P207	3.28	No	No	0	8	9
183	R:R:C429	R:R:I430	3.27	No	Yes	1	7	6
184	R:R:S41	R:R:V38	3.23	No	Yes	0	5	5
185	R:R:A155	R:R:M152	3.22	No	No	0	5	8
186	R:R:C105	R:R:L109	3.17	No	No	0	9	8
187	R:R:T412	R:R:V444	3.17	No	No	0	9	6
188	R:R:T447	R:R:V444	3.17	No	No	0	8	6
189	R:R:T196	R:R:T424	3.14	No	No	0	8	7
190	R:R:A203	R:R:N117	3.13	No	Yes	0	9	9
191	R:R:I402	R:R:S219	3.1	No	No	0	9	8
192	R:R:I437	R:R:S436	3.1	No	No	0	5	6
193	R:R:I35	R:R:V38	3.07	No	Yes	0	7	5
194	R:R:M86	R:R:S43	3.07	No	No	0	9	8
195	R:R:L467	R:R:S56	3	No	No	0	7	9
196	R:R:L138	R:R:T139	2.95	No	No	0	7	7
197	R:R:L406	R:R:T212	2.95	No	No	0	8	7
198	R:R:L411	R:R:T412	2.95	No	No	0	5	9
199	R:R:F170	R:R:P166	2.89	No	No	0	7	9
200	R:R:I51	R:R:L55	2.85	No	No	0	7	6
201	R:R:I80	R:R:L79	2.85	No	No	0	8	9
202	R:R:I216	R:R:L220	2.85	No	No	0	4	4
203	R:R:L79	R:R:M54	2.83	No	No	0	9	8
204	R:R:I448	R:R:N445	2.83	No	Yes	0	7	9
205	R:R:G101	R:R:W98	2.81	No	Yes	0	8	9
206	R:R:A165	R:R:F161	2.77	No	No	0	7	7
207	R:R:A167	R:R:F189	2.77	No	Yes	0	8	8
208	R:R:D106	R:R:Q172	2.61	No	No	8	8	7
209	R:R:D106	R:R:Q188	2.61	No	Yes	8	8	8
210	R:R:A77	R:R:W157	2.59	No	Yes	0	9	9
211	R:R:M148	R:R:R144	2.48	No	Yes	0	8	9
212	R:R:M391	R:R:R223	2.48	No	No	0	6	7
213	R:R:F84	R:R:L111	2.44	No	No	0	6	6
214	R:R:I168	R:R:Y113	2.42	No	Yes	0	8	9
215	R:R:K95	R:R:Y97	2.39	No	No	0	5	5
216	R:R:E395	R:R:R223	2.33	Yes	No	0	9	7
217	R:R:A165	R:R:P166	1.87	No	No	0	7	9
218	R:R:G40	R:R:S43	1.86	No	No	0	6	8
219	R:R:G49	R:R:V48	1.84	No	No	0	9	5
220	R:R:G176	R:R:V175	1.84	No	No	0	4	5
221	R:R:G96	R:R:I93	1.76	No	Yes	0	7	7
222	R:R:G198	R:R:I201	1.76	No	Yes	0	7	7
223	R:R:G438	R:R:I437	1.76	No	No	0	7	5
224	R:R:P431	R:R:T433	1.75	No	No	0	6	4
225	R:R:A77	R:R:S119	1.71	No	No	0	9	9
226	R:R:C426	R:R:V422	1.71	No	No	1	7	7
227	R:R:C429	R:R:V422	1.71	No	No	1	7	7
228	R:R:A75	R:R:V53	1.7	No	No	0	9	9
229	R:R:A165	R:R:V114	1.7	No	No	0	7	8
230	R:R:A221	R:R:V134	1.7	No	No	0	8	9
231	R:R:C456	R:R:T401	1.69	No	Yes	0	8	9
232	R:R:K136	R:R:P137	1.67	Yes	No	0	7	9
233	R:R:A110	R:R:I168	1.62	No	No	0	8	8
234	R:R:A202	R:R:I201	1.62	No	Yes	0	7	7
235	R:R:A408	R:R:I448	1.62	No	No	0	8	7
236	R:R:A156	R:R:M121	1.61	No	No	0	9	8
237	R:R:V30	R:R:V33	1.6	No	No	0	4	6
238	R:R:V47	R:R:V48	1.6	No	No	0	7	5
239	R:R:V103	R:R:V104	1.6	No	No	0	5	6
240	R:R:V114	R:R:V115	1.6	No	Yes	0	8	8
241	R:R:T37	R:R:V38	1.59	No	Yes	0	5	5
242	R:R:T39	R:R:V38	1.59	No	Yes	0	7	5
243	R:R:T447	R:R:V45	1.59	No	No	0	8	5
244	R:R:C76	R:R:L79	1.59	No	No	0	8	9
245	R:R:T90	R:R:V91	1.59	No	No	0	8	8
246	R:R:T196	R:R:V420	1.59	No	No	0	8	8
247	R:R:T212	R:R:V213	1.59	No	No	0	7	5
248	R:R:A200	R:R:L421	1.58	No	No	0	8	7
249	R:R:T39	R:R:T90	1.57	No	No	0	7	8
250	R:R:A194	R:R:N192	1.56	No	No	0	5	7
251	R:R:I51	R:R:V48	1.54	No	No	0	7	5
252	R:R:I210	R:R:V209	1.54	No	No	0	8	5
253	R:R:I216	R:R:T212	1.52	No	No	0	4	7
254	R:R:I405	R:R:T401	1.52	No	Yes	0	9	9
255	R:R:M148	R:R:T145	1.51	No	No	0	8	9
256	R:R:L42	R:R:S41	1.5	No	No	0	6	5
257	R:R:K147	R:R:T145	1.5	No	No	0	6	9
258	R:R:K462	R:R:T459	1.5	No	No	0	6	8
259	R:R:L44	R:R:V47	1.49	No	No	0	5	7
260	R:R:L107	R:R:V104	1.49	No	No	0	7	6
261	R:R:L163	R:R:V162	1.49	No	No	0	8	5
262	R:R:I94	R:R:K95	1.45	No	No	0	7	5
263	R:R:A404	R:R:R400	1.38	No	No	0	9	7
264	R:R:R400	R:R:T401	1.29	No	Yes	0	7	9
265	R:R:I402	R:R:Y215	1.21	No	Yes	0	9	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V38	2.37	4	0	5
2	R:R:D78	5.7525	4	4	9
3	R:R:Y89	11.31	4	2	8
4	R:R:I93	6.2175	4	0	7
5	R:R:W98	6.54143	7	0	9
6	R:R:W108	9.2975	4	2	7
7	R:R:D112	6.89	4	2	9
8	R:R:Y113	4.8475	4	0	9
9	R:R:V115	3.93	4	0	8
10	R:R:N117	7.4625	4	0	9
11	R:R:F128	5.235	4	0	7
12	R:R:D129	8.3925	4	3	9
13	R:R:Y131	6	5	0	9
14	R:R:K136	5.606	5	6	7
15	R:R:Y140	9.598	5	3	9
16	R:R:R144	7.69667	6	3	9
17	R:R:W157	5.3625	4	0	9
18	R:R:Q188	7.59	4	8	8
19	R:R:F189	6.814	5	7	8
20	R:R:I201	4.2525	4	0	7
21	R:R:F204	12.1475	4	0	9
22	R:R:Y215	5.354	5	0	9
23	R:R:E395	4.155	4	0	9
24	R:R:T401	2.6275	4	0	9
25	R:R:W413	8.46333	6	9	9
26	R:R:Y416	5.932	5	0	9
27	R:R:M419	6.875	4	1	7
28	R:R:I430	5.238	5	1	6
29	R:R:Y439	11.8125	4	2	7
30	R:R:Y443	9.515	4	2	9
31	R:R:N445	7.284	5	9	9
32	R:R:F464	5.4475	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V115	R:R:W157	27.9641	4.9	Yes	Yes	0	8	9
2	R:R:S73	R:R:W157	31.9416	6.18	No	Yes	0	9	9
3	R:R:N122	R:R:S73	27.3003	5.96	No	No	0	9	9
4	R:R:I126	R:R:N122	28.2649	4.25	No	No	0	9	9
5	R:R:I126	R:R:R130	86.9893	6.26	No	No	0	9	9
6	R:R:R130	R:R:Y453	87.4905	9.26	No	No	0	9	9
7	R:R:L123	R:R:Y453	99.0436	5.86	No	No	0	9	9
8	R:R:L123	R:R:N449	99.5286	4.12	No	No	0	9	9
9	R:R:N445	R:R:N449	100	6.81	Yes	No	0	9	9
10	R:R:I80	R:R:L79	10.0927	2.85	No	No	0	8	9
11	R:R:I80	R:R:V115	14.4386	4.61	No	Yes	0	8	8
12	R:R:L63	R:R:N60	10.9976	9.61	No	No	0	9	8
13	R:R:F460	R:R:L63	16.2214	7.31	No	No	0	9	9
14	R:R:F460	R:R:L71	21.3287	3.65	No	No	0	9	8
15	R:R:L71	R:R:Y453	22.3637	5.86	No	No	0	8	9
16	R:R:F70	R:R:I126	58.4833	5.02	No	No	0	8	9
17	R:R:F70	R:R:I125	61.7265	3.77	No	No	0	8	8
18	R:R:F128	R:R:I125	59.4072	3.77	Yes	No	0	7	8
19	R:R:F128	R:R:L214	56.0935	6.09	Yes	No	0	7	8
20	R:R:L214	R:R:Y131	32.8574	4.69	No	Yes	0	8	9
21	R:R:F132	R:R:Y131	21.4859	5.16	No	Yes	0	7	9
22	R:R:F132	R:R:Y140	15.2948	14.44	No	Yes	0	7	9
23	R:R:S85	R:R:W108	29.5302	4.94	No	Yes	2	9	7
24	R:R:W108	R:R:Y439	29.4814	6.75	Yes	Yes	2	7	7
25	R:R:L88	R:R:W108	57.5295	21.64	No	Yes	0	7	7
26	R:R:L88	R:R:W98	55.744	7.97	No	Yes	0	7	9
27	R:R:Y439	R:R:Y89	10.1062	20.85	Yes	Yes	2	7	8
28	R:R:P99	R:R:W98	30.7982	5.4	No	Yes	0	5	9
29	R:R:P99	R:R:Y97	28.8962	4.17	No	No	0	5	5
30	R:R:N183	R:R:Y97	23.1576	4.65	No	No	0	4	5
31	R:R:F186	R:R:V180	15.4303	11.8	No	No	0	4	5
32	R:R:F186	R:R:Q184	17.3702	4.68	No	No	0	4	5
33	R:R:N183	R:R:Q184	19.2777	18.49	No	No	5	4	5
34	R:R:D112	R:R:Y113	71.3125	5.75	Yes	Yes	0	9	9
35	R:R:I187	R:R:Y113	21.6376	7.25	No	Yes	0	7	9
36	R:R:Y113	R:R:Y416	85.8757	3.97	Yes	Yes	0	9	9
37	R:R:T199	R:R:W164	10.1089	10.92	No	No	0	9	8
38	R:R:F189	R:R:T199	11.1331	9.08	Yes	No	0	8	9
39	R:R:F189	R:R:I187	19.6326	5.02	Yes	No	0	8	7
40	R:R:L214	R:R:S127	26.5119	6.01	No	No	0	8	9
41	R:R:S127	R:R:Y215	25.4985	8.9	No	Yes	0	9	9
42	R:R:N417	R:R:Y416	50.8562	4.65	No	Yes	0	9	9
43	R:R:N445	R:R:W413	94.8358	9.04	Yes	Yes	9	9	9
44	R:R:N417	R:R:W413	50.7993	5.65	No	Yes	0	9	9
45	R:R:C442	R:R:Y416	46.5753	6.72	No	Yes	0	9	9
46	R:R:C442	R:R:W413	46.6051	15.67	No	Yes	0	9	9
47	R:R:W435	R:R:Y416	19.7464	6.75	No	Yes	0	6	9
48	R:R:M419	R:R:W435	11.1006	5.82	Yes	No	1	7	6
49	R:R:V91	R:R:W98	15.5603	3.68	No	Yes	0	8	9
50	R:R:T90	R:R:V91	13.6149	1.59	No	No	0	8	8
51	R:R:T39	R:R:T90	11.6641	1.57	No	No	0	7	8
52	R:R:D112	R:R:S85	29.3541	10.31	Yes	No	2	9	9
53	R:R:D112	R:R:Y439	39.0945	5.75	Yes	Yes	2	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7V69_nogp

PDB Summary
PDB	7V69_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	244
Number of Links	265
Number of Hubs	32
Number of Links mediated by Hubs	128
Number of Communities	9
Number of Nodes involved in Communities	38
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	56492
Length Of Smallest Path	3
Average Path Length	17.8867
Length of Longest Path	35
Minimum Path Strength	1.335
Average Path Strength	6.60856
Maximum Path Strength	19.73
Minimum Path Correlation	0.7
Average Path Correlation	0.924036
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	38.3461
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.7769
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>7V69_nogp_Chain_R T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G Y W P L G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F I Q F L S N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F K K T F R H L L L C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	doi.org/10.1038/s41594-022-00796-6
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	doi.org/10.1038/s41467-023-41199-5
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	doi.org/10.2139/ssrn.4034884
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275	Gi1/β1/γ2	3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	PubChem 9864275		3.6	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	doi.org/10.1038/nature17188
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	doi.org/10.1038/s41586-022-05489-0
	6KP6	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	-	3	2020-03-11	doi.org/10.1107/S2052252520000597
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	doi.org/10.2139/ssrn.4034884
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	doi.org/10.1038/s41467-017-00630-4
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	9M4Q	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Doxazosin	-	-	2.99	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	9M4T	A	Amine	Adrenegic	Alpha1A	Homo sapiens	Silodosin	-	-	3.19	2025-07-02	doi.org/10.1016/j.jbc.2025.110348
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	doi.org/10.1038/nature25758
	9IQS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	Muscarinic toxin 3	-	3.6	2025-07-23	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7V69_nogp.zip

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