psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N87	R:R:S43	5.96	No	No	0	9	8
2	R:R:M86	R:R:T46	4.52	No	No	0	9	8
3	R:R:T447	R:R:T46	10.99	No	No	0	8	8
4	R:R:D78	R:R:N50	8.08	Yes	No	4	9	9
5	R:R:N50	R:R:P450	6.52	No	No	4	9	9
6	R:R:I51	R:R:M54	4.37	No	No	0	7	8
7	R:R:F464	R:R:L52	9.74	Yes	No	0	9	8
8	R:R:F464	R:R:V53	3.93	Yes	No	0	9	9
9	R:R:S56	R:R:T463	7.99	No	No	0	9	9
10	R:R:F464	R:R:S56	3.96	Yes	No	0	9	9
11	R:R:I57	R:R:N68	4.25	No	No	0	9	9
12	R:R:F72	R:R:I57	6.28	No	No	0	8	9
13	R:R:N60	R:R:Q62	11.88	No	No	0	8	6
14	R:R:L63	R:R:N60	9.61	No	No	0	9	8
15	R:R:N60	R:R:T463	7.31	No	No	0	8	9
16	R:R:Q62	R:R:T459	11.34	No	No	0	6	8
17	R:R:L63	R:R:N68	4.12	No	No	0	9	9
18	R:R:F460	R:R:L63	7.31	No	No	0	9	9
19	R:R:N68	R:R:T65	5.85	No	No	0	9	8
20	R:R:V66	R:R:Y69	5.05	No	No	0	8	7
21	R:R:R144	R:R:V66	7.85	Yes	No	0	9	8
22	R:R:D129	R:R:N67	6.73	Yes	No	3	9	9
23	R:R:N67	R:R:R144	10.85	No	Yes	3	9	9
24	R:R:F70	R:R:I125	3.77	No	No	0	8	8
25	R:R:F70	R:R:I126	5.02	No	No	0	8	9
26	R:R:F70	R:R:I153	10.05	No	No	0	8	9
27	R:R:L71	R:R:Y453	5.86	No	No	0	8	9
28	R:R:N122	R:R:S73	5.96	No	No	0	9	9
29	R:R:I153	R:R:S73	6.19	No	No	0	9	9
30	R:R:S73	R:R:W157	6.18	No	Yes	0	9	9
31	R:R:D78	R:R:L74	4.07	Yes	No	0	9	9
32	R:R:D78	R:R:S446	4.42	Yes	No	0	9	9
33	R:R:D78	R:R:P450	6.44	Yes	No	4	9	9
34	R:R:F84	R:R:I80	6.28	No	No	0	6	8
35	R:R:I80	R:R:V115	4.61	No	Yes	0	8	8
36	R:R:I81	R:R:V115	4.61	No	Yes	0	9	8
37	R:R:I81	R:R:S446	4.64	No	No	0	9	9
38	R:R:A83	R:R:F84	4.16	No	No	0	5	6
39	R:R:S85	R:R:W108	4.94	No	Yes	2	9	7
40	R:R:D112	R:R:S85	10.31	Yes	No	2	9	9
41	R:R:S85	R:R:Y443	7.63	No	Yes	2	9	9
42	R:R:M86	R:R:Y443	10.78	No	Yes	0	9	9
43	R:R:L88	R:R:W98	7.97	No	Yes	0	7	9
44	R:R:L88	R:R:W108	21.64	No	Yes	0	7	7
45	R:R:I93	R:R:Y89	10.88	Yes	Yes	0	7	8
46	R:R:W108	R:R:Y89	3.86	Yes	Yes	2	7	8
47	R:R:Y439	R:R:Y89	20.85	Yes	Yes	2	7	8
48	R:R:W440	R:R:Y89	9.65	No	Yes	0	9	8
49	R:R:I93	R:R:Y92	6.04	Yes	No	0	7	8
50	R:R:W98	R:R:Y92	4.82	Yes	No	0	9	8
51	R:R:C185	R:R:Y92	4.03	No	No	0	9	8
52	R:R:I93	R:R:S436	6.19	Yes	No	0	7	6
53	R:R:P99	R:R:Y97	4.17	No	No	0	5	5
54	R:R:N183	R:R:Y97	4.65	No	No	0	4	5
55	R:R:P99	R:R:W98	5.4	No	Yes	0	5	9
56	R:R:L100	R:R:W98	12.53	No	Yes	0	7	9
57	R:R:V104	R:R:W98	8.58	No	Yes	0	6	9
58	R:R:A102	R:R:R178	4.15	No	No	0	4	5
59	R:R:A102	R:R:D182	4.63	No	No	0	4	3
60	R:R:C105	R:R:C185	7.28	No	No	0	9	9
61	R:R:W108	R:R:Y439	6.75	Yes	Yes	2	7	7
62	R:R:A110	R:R:L169	4.73	No	No	0	8	6
63	R:R:D112	R:R:Y113	5.75	Yes	Yes	0	9	9
64	R:R:D112	R:R:Y439	5.75	Yes	Yes	2	9	7
65	R:R:D112	R:R:Y443	5.75	Yes	Yes	2	9	9
66	R:R:I187	R:R:Y113	7.25	No	Yes	0	7	9
67	R:R:Y113	R:R:Y416	3.97	Yes	Yes	0	9	9
68	R:R:V115	R:R:W157	4.9	Yes	Yes	0	8	9
69	R:R:M121	R:R:N117	9.82	No	Yes	0	8	9
70	R:R:N117	R:R:S160	4.47	Yes	No	0	9	9
71	R:R:N117	R:R:W164	12.43	Yes	No	0	9	8
72	R:R:A118	R:R:W157	7.78	No	Yes	0	9	9
73	R:R:I126	R:R:N122	4.25	No	No	0	9	9
74	R:R:L123	R:R:N449	4.12	No	No	0	9	9
75	R:R:L123	R:R:Y453	5.86	No	No	0	9	9
76	R:R:F128	R:R:L124	7.31	Yes	No	0	7	8
77	R:R:F128	R:R:I125	3.77	Yes	No	0	7	8
78	R:R:I125	R:R:M152	7.29	No	No	0	8	8
79	R:R:I126	R:R:R130	6.26	No	No	0	9	9
80	R:R:L214	R:R:S127	6.01	No	No	0	8	9
81	R:R:S127	R:R:Y215	8.9	No	Yes	0	9	9
82	R:R:F128	R:R:I210	3.77	Yes	No	0	7	8
83	R:R:F128	R:R:L214	6.09	Yes	No	0	7	8
84	R:R:C133	R:R:D129	4.67	No	Yes	3	9	9
85	R:R:D129	R:R:Y140	12.64	Yes	Yes	3	9	9
86	R:R:D129	R:R:R144	9.53	Yes	Yes	3	9	9
87	R:R:R130	R:R:Y453	9.26	No	No	0	9	9
88	R:R:F132	R:R:Y131	5.16	No	Yes	0	7	9
89	R:R:T135	R:R:Y131	9.99	No	Yes	0	9	9
90	R:R:L214	R:R:Y131	4.69	No	Yes	0	8	9
91	R:R:H217	R:R:Y131	6.53	No	Yes	0	7	9
92	R:R:F132	R:R:K136	12.41	No	Yes	0	7	7
93	R:R:F132	R:R:Y140	14.44	No	Yes	0	7	9
94	R:R:C133	R:R:Y140	4.03	No	Yes	3	9	9
95	R:R:I218	R:R:V134	4.61	No	No	0	9	9
96	R:R:K136	R:R:T135	4.5	Yes	No	0	7	9
97	R:R:K136	R:R:T139	4.5	Yes	No	6	7	7
98	R:R:K136	R:R:R143	4.95	Yes	No	6	7	6
99	R:R:R143	R:R:T139	7.76	No	No	6	6	7
100	R:R:P141	R:R:Y140	5.56	No	Yes	0	7	9
101	R:R:R144	R:R:Y140	11.32	Yes	Yes	3	9	9
102	R:R:A149	R:R:R144	4.15	No	Yes	0	8	9
103	R:R:L151	R:R:M148	5.65	No	No	0	3	8
104	R:R:L159	R:R:L163	4.15	No	No	0	6	8
105	R:R:L163	R:R:W164	17.08	No	No	0	8	8
106	R:R:T199	R:R:W164	10.92	No	No	0	9	8
107	R:R:F189	R:R:W171	8.02	Yes	No	7	8	7
108	R:R:V195	R:R:W171	4.9	No	No	7	8	7
109	R:R:Q172	R:R:Q188	19.2	No	Yes	8	7	8
110	R:R:R178	R:R:V180	7.85	No	No	0	5	5
111	R:R:Q188	R:R:T179	4.25	Yes	No	0	8	5
112	R:R:F186	R:R:V180	11.8	No	No	0	4	5
113	R:R:Q188	R:R:V180	4.3	Yes	No	0	8	5
114	R:R:N183	R:R:P181	4.89	No	No	5	4	3
115	R:R:P181	R:R:Q184	14.21	No	No	5	3	5
116	R:R:N183	R:R:Q184	18.49	No	No	5	4	5
117	R:R:F186	R:R:Q184	4.68	No	No	0	4	5
118	R:R:F189	R:R:I187	5.02	Yes	No	0	8	7
119	R:R:I187	R:R:L190	8.56	No	No	0	7	5
120	R:R:F189	R:R:V195	9.18	Yes	No	7	8	8
121	R:R:F189	R:R:T199	9.08	Yes	No	0	8	9
122	R:R:N192	R:R:P193	4.89	No	No	0	7	5
123	R:R:N192	R:R:V195	7.39	No	No	0	7	8
124	R:R:F197	R:R:I201	8.79	No	Yes	0	7	7
125	R:R:I201	R:R:Y205	4.84	Yes	No	0	7	8
126	R:R:F204	R:R:Y205	16.5	Yes	No	0	9	8
127	R:R:F204	R:R:V208	5.24	Yes	No	0	9	8
128	R:R:F204	R:R:T414	3.89	Yes	No	0	9	7
129	R:R:F204	R:R:N417	22.96	Yes	No	0	9	9
130	R:R:F409	R:R:V208	3.93	No	No	0	9	8
131	R:R:M211	R:R:Y215	4.79	No	Yes	0	9	9
132	R:R:I405	R:R:Y215	4.84	No	Yes	0	9	9
133	R:R:L406	R:R:Y215	7.03	No	Yes	0	8	9
134	R:R:E395	R:R:S219	4.31	Yes	No	0	9	8
135	R:R:E395	R:R:S222	5.75	Yes	No	0	9	9
136	R:R:S222	R:R:V398	6.46	No	No	0	9	9
137	R:R:E395	R:R:T399	4.23	Yes	No	0	9	9
138	R:R:K397	R:R:T401	6.01	No	Yes	0	9	9
139	R:R:F403	R:R:L407	7.31	No	No	0	8	8
140	R:R:I410	R:R:L406	4.28	No	No	0	8	8
141	R:R:I410	R:R:L407	4.28	No	No	0	8	8
142	R:R:F409	R:R:W413	13.03	No	Yes	9	9	9
143	R:R:F409	R:R:N445	6.04	No	Yes	9	9	9
144	R:R:N445	R:R:T412	11.7	Yes	No	0	9	9
145	R:R:N417	R:R:W413	5.65	No	Yes	0	9	9
146	R:R:C442	R:R:W413	15.67	No	Yes	0	9	9
147	R:R:N445	R:R:W413	9.04	Yes	Yes	9	9	9
148	R:R:P415	R:R:T414	5.25	No	No	0	9	7
149	R:R:L441	R:R:P415	4.93	No	No	0	9	9
150	R:R:N417	R:R:Y416	4.65	No	Yes	0	9	9
151	R:R:V420	R:R:Y416	7.57	No	Yes	0	8	9
152	R:R:W435	R:R:Y416	6.75	No	Yes	0	6	9
153	R:R:C442	R:R:Y416	6.72	No	Yes	0	9	9
154	R:R:M419	R:R:N423	11.22	Yes	No	1	7	5
155	R:R:I430	R:R:M419	4.37	Yes	Yes	1	6	7
156	R:R:M419	R:R:V434	6.09	Yes	No	1	7	5
157	R:R:M419	R:R:W435	5.82	Yes	No	1	7	6
158	R:R:I430	R:R:N423	4.25	Yes	No	1	6	5
159	R:R:N423	R:R:W435	4.52	No	No	1	5	6
160	R:R:F425	R:R:T424	7.78	No	No	0	6	7
161	R:R:C426	R:R:C429	7.28	No	No	1	7	7
162	R:R:I430	R:R:P431	5.08	Yes	No	1	6	6
163	R:R:I430	R:R:V434	9.22	Yes	No	1	6	5
164	R:R:P431	R:R:V434	5.3	No	No	1	6	5
165	R:R:Y439	R:R:Y443	13.9	Yes	Yes	2	7	9
166	R:R:N445	R:R:N449	6.81	Yes	No	0	9	9
167	R:R:C452	R:R:I448	4.91	No	No	0	9	7
168	R:R:A454	R:R:F464	4.16	No	Yes	0	9	9
169	R:R:N457	R:R:T459	5.85	No	No	0	9	8
170	R:R:F460	R:R:N457	8.46	No	No	0	9	9
171	R:R:L468	R:R:R465	4.86	No	No	0	8	6
172	R:R:S116	R:R:W413	3.71	No	Yes	0	8	9
173	R:R:V91	R:R:W98	3.68	No	Yes	0	8	9
174	R:R:V120	R:R:W413	3.68	No	Yes	0	9	9
175	R:R:V174	R:R:W171	3.68	No	No	0	5	7
176	R:R:F460	R:R:L71	3.65	No	No	0	9	8
177	R:R:I218	R:R:Y131	3.63	No	Yes	0	9	9
178	R:R:G82	R:R:I81	3.53	No	No	0	9	9
179	R:R:P207	R:R:V120	3.53	No	No	0	9	9
180	R:R:G150	R:R:I153	3.53	No	No	0	5	9
181	R:R:L421	R:R:Y205	3.52	No	No	0	7	8
182	R:R:L206	R:R:P207	3.28	No	No	0	8	9
183	R:R:C429	R:R:I430	3.27	No	Yes	1	7	6
184	R:R:S41	R:R:V38	3.23	No	Yes	0	5	5
185	R:R:A155	R:R:M152	3.22	No	No	0	5	8
186	R:R:C105	R:R:L109	3.17	No	No	0	9	8
187	R:R:T412	R:R:V444	3.17	No	No	0	9	6
188	R:R:T447	R:R:V444	3.17	No	No	0	8	6
189	R:R:T196	R:R:T424	3.14	No	No	0	8	7
190	R:R:A203	R:R:N117	3.13	No	Yes	0	9	9
191	R:R:I402	R:R:S219	3.1	No	No	0	9	8
192	R:R:I437	R:R:S436	3.1	No	No	0	5	6
193	R:R:I35	R:R:V38	3.07	No	Yes	0	7	5
194	R:R:M86	R:R:S43	3.07	No	No	0	9	8
195	R:R:L467	R:R:S56	3	No	No	0	7	9
196	R:R:L138	R:R:T139	2.95	No	No	0	7	7
197	R:R:L406	R:R:T212	2.95	No	No	0	8	7
198	R:R:L411	R:R:T412	2.95	No	No	0	5	9
199	R:R:F170	R:R:P166	2.89	No	No	0	7	9
200	R:R:I51	R:R:L55	2.85	No	No	0	7	6
201	R:R:I80	R:R:L79	2.85	No	No	0	8	9
202	R:R:I216	R:R:L220	2.85	No	No	0	4	4
203	R:R:L79	R:R:M54	2.83	No	No	0	9	8
204	R:R:I448	R:R:N445	2.83	No	Yes	0	7	9
205	R:R:G101	R:R:W98	2.81	No	Yes	0	8	9
206	R:R:A165	R:R:F161	2.77	No	No	0	7	7
207	R:R:A167	R:R:F189	2.77	No	Yes	0	8	8
208	R:R:D106	R:R:Q172	2.61	No	No	8	8	7
209	R:R:D106	R:R:Q188	2.61	No	Yes	8	8	8
210	R:R:A77	R:R:W157	2.59	No	Yes	0	9	9
211	R:R:M148	R:R:R144	2.48	No	Yes	0	8	9
212	R:R:M391	R:R:R223	2.48	No	No	0	6	7
213	R:R:F84	R:R:L111	2.44	No	No	0	6	6
214	R:R:I168	R:R:Y113	2.42	No	Yes	0	8	9
215	R:R:K95	R:R:Y97	2.39	No	No	0	5	5
216	R:R:E395	R:R:R223	2.33	Yes	No	0	9	7
217	R:R:A165	R:R:P166	1.87	No	No	0	7	9
218	R:R:G40	R:R:S43	1.86	No	No	0	6	8
219	R:R:G49	R:R:V48	1.84	No	No	0	9	5
220	R:R:G176	R:R:V175	1.84	No	No	0	4	5
221	R:R:G96	R:R:I93	1.76	No	Yes	0	7	7
222	R:R:G198	R:R:I201	1.76	No	Yes	0	7	7
223	R:R:G438	R:R:I437	1.76	No	No	0	7	5
224	R:R:P431	R:R:T433	1.75	No	No	0	6	4
225	R:R:A77	R:R:S119	1.71	No	No	0	9	9
226	R:R:C426	R:R:V422	1.71	No	No	1	7	7
227	R:R:C429	R:R:V422	1.71	No	No	1	7	7
228	R:R:A75	R:R:V53	1.7	No	No	0	9	9
229	R:R:A165	R:R:V114	1.7	No	No	0	7	8
230	R:R:A221	R:R:V134	1.7	No	No	0	8	9
231	R:R:C456	R:R:T401	1.69	No	Yes	0	8	9
232	R:R:K136	R:R:P137	1.67	Yes	No	0	7	9
233	R:R:A110	R:R:I168	1.62	No	No	0	8	8
234	R:R:A202	R:R:I201	1.62	No	Yes	0	7	7
235	R:R:A408	R:R:I448	1.62	No	No	0	8	7
236	R:R:A156	R:R:M121	1.61	No	No	0	9	8
237	R:R:V30	R:R:V33	1.6	No	No	0	4	6
238	R:R:V47	R:R:V48	1.6	No	No	0	7	5
239	R:R:V103	R:R:V104	1.6	No	No	0	5	6
240	R:R:V114	R:R:V115	1.6	No	Yes	0	8	8
241	R:R:T37	R:R:V38	1.59	No	Yes	0	5	5
242	R:R:T39	R:R:V38	1.59	No	Yes	0	7	5
243	R:R:T447	R:R:V45	1.59	No	No	0	8	5
244	R:R:C76	R:R:L79	1.59	No	No	0	8	9
245	R:R:T90	R:R:V91	1.59	No	No	0	8	8
246	R:R:T196	R:R:V420	1.59	No	No	0	8	8
247	R:R:T212	R:R:V213	1.59	No	No	0	7	5
248	R:R:A200	R:R:L421	1.58	No	No	0	8	7
249	R:R:T39	R:R:T90	1.57	No	No	0	7	8
250	R:R:A194	R:R:N192	1.56	No	No	0	5	7
251	R:R:I51	R:R:V48	1.54	No	No	0	7	5
252	R:R:I210	R:R:V209	1.54	No	No	0	8	5
253	R:R:I216	R:R:T212	1.52	No	No	0	4	7
254	R:R:I405	R:R:T401	1.52	No	Yes	0	9	9
255	R:R:M148	R:R:T145	1.51	No	No	0	8	9
256	R:R:L42	R:R:S41	1.5	No	No	0	6	5
257	R:R:K147	R:R:T145	1.5	No	No	0	6	9
258	R:R:K462	R:R:T459	1.5	No	No	0	6	8
259	R:R:L44	R:R:V47	1.49	No	No	0	5	7
260	R:R:L107	R:R:V104	1.49	No	No	0	7	6
261	R:R:L163	R:R:V162	1.49	No	No	0	8	5
262	R:R:I94	R:R:K95	1.45	No	No	0	7	5
263	R:R:A404	R:R:R400	1.38	No	No	0	9	7
264	R:R:R400	R:R:T401	1.29	No	Yes	0	7	9
265	R:R:I402	R:R:Y215	1.21	No	Yes	0	9	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V38	2.37	4	0	5
2	R:R:D78	5.7525	4	4	9
3	R:R:Y89	11.31	4	2	8
4	R:R:I93	6.2175	4	0	7
5	R:R:W98	6.54143	7	0	9
6	R:R:W108	9.2975	4	2	7
7	R:R:D112	6.89	4	2	9
8	R:R:Y113	4.8475	4	0	9
9	R:R:V115	3.93	4	0	8
10	R:R:N117	7.4625	4	0	9
11	R:R:F128	5.235	4	0	7
12	R:R:D129	8.3925	4	3	9
13	R:R:Y131	6	5	0	9
14	R:R:K136	5.606	5	6	7
15	R:R:Y140	9.598	5	3	9
16	R:R:R144	7.69667	6	3	9
17	R:R:W157	5.3625	4	0	9
18	R:R:Q188	7.59	4	8	8
19	R:R:F189	6.814	5	7	8
20	R:R:I201	4.2525	4	0	7
21	R:R:F204	12.1475	4	0	9
22	R:R:Y215	5.354	5	0	9
23	R:R:E395	4.155	4	0	9
24	R:R:T401	2.6275	4	0	9
25	R:R:W413	8.46333	6	9	9
26	R:R:Y416	5.932	5	0	9
27	R:R:M419	6.875	4	1	7
28	R:R:I430	5.238	5	1	6
29	R:R:Y439	11.8125	4	2	7
30	R:R:Y443	9.515	4	2	9
31	R:R:N445	7.284	5	9	9
32	R:R:F464	5.4475	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V115	R:R:W157	27.9641	4.9	Yes	Yes	0	8	9
2	R:R:S73	R:R:W157	31.9416	6.18	No	Yes	0	9	9
3	R:R:N122	R:R:S73	27.3003	5.96	No	No	0	9	9
4	R:R:I126	R:R:N122	28.2649	4.25	No	No	0	9	9
5	R:R:I126	R:R:R130	86.9893	6.26	No	No	0	9	9
6	R:R:R130	R:R:Y453	87.4905	9.26	No	No	0	9	9
7	R:R:L123	R:R:Y453	99.0436	5.86	No	No	0	9	9
8	R:R:L123	R:R:N449	99.5286	4.12	No	No	0	9	9
9	R:R:N445	R:R:N449	100	6.81	Yes	No	0	9	9
10	R:R:I80	R:R:L79	10.0927	2.85	No	No	0	8	9
11	R:R:I80	R:R:V115	14.4386	4.61	No	Yes	0	8	8
12	R:R:L63	R:R:N60	10.9976	9.61	No	No	0	9	8
13	R:R:F460	R:R:L63	16.2214	7.31	No	No	0	9	9
14	R:R:F460	R:R:L71	21.3287	3.65	No	No	0	9	8
15	R:R:L71	R:R:Y453	22.3637	5.86	No	No	0	8	9
16	R:R:F70	R:R:I126	58.4833	5.02	No	No	0	8	9
17	R:R:F70	R:R:I125	61.7265	3.77	No	No	0	8	8
18	R:R:F128	R:R:I125	59.4072	3.77	Yes	No	0	7	8
19	R:R:F128	R:R:L214	56.0935	6.09	Yes	No	0	7	8
20	R:R:L214	R:R:Y131	32.8574	4.69	No	Yes	0	8	9
21	R:R:F132	R:R:Y131	21.4859	5.16	No	Yes	0	7	9
22	R:R:F132	R:R:Y140	15.2948	14.44	No	Yes	0	7	9
23	R:R:S85	R:R:W108	29.5302	4.94	No	Yes	2	9	7
24	R:R:W108	R:R:Y439	29.4814	6.75	Yes	Yes	2	7	7
25	R:R:L88	R:R:W108	57.5295	21.64	No	Yes	0	7	7
26	R:R:L88	R:R:W98	55.744	7.97	No	Yes	0	7	9
27	R:R:Y439	R:R:Y89	10.1062	20.85	Yes	Yes	2	7	8
28	R:R:P99	R:R:W98	30.7982	5.4	No	Yes	0	5	9
29	R:R:P99	R:R:Y97	28.8962	4.17	No	No	0	5	5
30	R:R:N183	R:R:Y97	23.1576	4.65	No	No	0	4	5
31	R:R:F186	R:R:V180	15.4303	11.8	No	No	0	4	5
32	R:R:F186	R:R:Q184	17.3702	4.68	No	No	0	4	5
33	R:R:N183	R:R:Q184	19.2777	18.49	No	No	5	4	5
34	R:R:D112	R:R:Y113	71.3125	5.75	Yes	Yes	0	9	9
35	R:R:I187	R:R:Y113	21.6376	7.25	No	Yes	0	7	9
36	R:R:Y113	R:R:Y416	85.8757	3.97	Yes	Yes	0	9	9
37	R:R:T199	R:R:W164	10.1089	10.92	No	No	0	9	8
38	R:R:F189	R:R:T199	11.1331	9.08	Yes	No	0	8	9
39	R:R:F189	R:R:I187	19.6326	5.02	Yes	No	0	8	7
40	R:R:L214	R:R:S127	26.5119	6.01	No	No	0	8	9
41	R:R:S127	R:R:Y215	25.4985	8.9	No	Yes	0	9	9
42	R:R:N417	R:R:Y416	50.8562	4.65	No	Yes	0	9	9
43	R:R:N445	R:R:W413	94.8358	9.04	Yes	Yes	9	9	9
44	R:R:N417	R:R:W413	50.7993	5.65	No	Yes	0	9	9
45	R:R:C442	R:R:Y416	46.5753	6.72	No	Yes	0	9	9
46	R:R:C442	R:R:W413	46.6051	15.67	No	Yes	0	9	9
47	R:R:W435	R:R:Y416	19.7464	6.75	No	Yes	0	6	9
48	R:R:M419	R:R:W435	11.1006	5.82	Yes	No	1	7	6
49	R:R:V91	R:R:W98	15.5603	3.68	No	Yes	0	8	9
50	R:R:T90	R:R:V91	13.6149	1.59	No	No	0	8	8
51	R:R:T39	R:R:T90	11.6641	1.57	No	No	0	7	8
52	R:R:D112	R:R:S85	29.3541	10.31	Yes	No	2	9	9
53	R:R:D112	R:R:Y439	39.0945	5.75	Yes	Yes	2	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7V69_nogp

PDB Summary
PDB	7V69_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	244
Number of Links	265
Number of Hubs	32
Number of Links mediated by Hubs	128
Number of Communities	9
Number of Nodes involved in Communities	38
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	56492
Length Of Smallest Path	3
Average Path Length	17.8867
Length of Longest Path	35
Minimum Path Strength	1.335
Average Path Strength	6.60856
Maximum Path Strength	19.73
Minimum Path Correlation	0.7
Average Path Correlation	0.923835
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	38.3582
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.7769
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08173
Sequence	>7V69_nogp_Chain_R T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N R Q L Q T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G Y W P L G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K P L T Y P A R R T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G K R T V P D N Q C F I Q F L S N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C Q S C I P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F K K T F R H L L L C Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8FX5	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline	Gi1/β1/γ2	2.45	2023-09-13	10.1038/s41467-023-41199-5
	8FX5 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Xanomeline	Xanomeline		2.45	2023-09-13	10.1038/s41467-023-41199-5
	7TRS	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-	Gi1/β1/γ2	2.8	2023-05-17	10.2139/ssrn.4034884
	7TRS (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Acetylcholine	-		2.8	2023-05-17	10.2139/ssrn.4034884
	7TRQ	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154	Gi1/β1/γ2	2.5	2023-05-17	10.2139/ssrn.4034884
	7TRQ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	VU0467154		2.5	2023-05-17	10.2139/ssrn.4034884
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	10.2139/ssrn.4034884
	7TRK	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-	Gi1/β1/γ2	2.8	2023-05-17	10.2139/ssrn.4034884
	7TRK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	-		2.8	2023-05-17	10.2139/ssrn.4034884
	8E9X	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-	chim(NtGi1-Go)/β1/γ2	2.7	2022-11-30	10.1038/s41586-022-05489-0
	8E9X (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	2-Deoxycytidine	-		2.7	2022-11-30	10.1038/s41586-022-05489-0
	7UM4	A	Amine	5-Hydroxytryptamine	5-HT_5A	Homo sapiens	AS2674723	-	-	2.8	2022-07-20	10.1038/s41594-022-00796-6
	7V6A	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	PubChem 9864275	-	Gi1/β1/γ2	3.6	2022-05-11	10.1038/s41467-022-30595-y
	7V6A (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	PubChem 9864275	-		3.6	2022-05-11	10.1038/s41467-022-30595-y
	7V69	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2022-05-11	10.1038/s41467-022-30595-y
	7V69 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-		3.4	2022-05-11	10.1038/s41467-022-30595-y
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	PubChem 57664406	Gi1/β1/γ2	3.4	2022-05-11	10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	PubChem 57664406		3.4	2022-05-11	10.1038/s41467-022-30595-y
	6KP6	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	-	-	-	3	2020-03-11	10.1107/S2052252520000597
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	10.1038/nature25758
	5OM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2	2018-01-17	10.1038/s41598-017-18570-w
	5NM4	A	Nucleotide	Adenosine	A_2A	Homo sapiens	ZM-241385	Na	-	1.7	2017-09-27	10.1038/s41467-017-00630-4
	5DSG	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Tiotropium	-	-	2.6	2016-03-16	10.1038/nature17188

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