psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y34	R:R:Y36	5.96	No	No	0	6	5
2	R:R:V96	R:R:Y34	3.79	No	No	5	6	6
3	R:R:V97	R:R:Y34	5.05	Yes	No	5	5	6
4	R:R:N35	R:R:Y37	3.49	No	No	0	7	5
5	R:R:L41	R:R:W413	12.53	No	Yes	0	7	8
6	R:R:I45	R:R:M88	5.83	No	Yes	0	8	9
7	R:R:I48	R:R:V49	4.61	Yes	No	0	8	7
8	R:R:I48	R:R:N52	5.66	Yes	Yes	0	8	9
9	R:R:A84	R:R:I48	3.25	No	Yes	0	8	8
10	R:R:F50	R:R:L54	4.87	No	Yes	0	5	8
11	R:R:G51	R:R:P423	4.06	No	No	0	9	9
12	R:R:A77	R:R:N52	4.69	No	Yes	0	9	9
13	R:R:D80	R:R:N52	12.12	No	Yes	0	9	9
14	R:R:N52	R:R:P423	14.66	Yes	No	0	9	9
15	R:R:F437	R:R:L54	3.65	No	Yes	0	9	8
16	R:R:T427	R:R:V55	3.17	Yes	No	0	8	9
17	R:R:V59	R:R:V74	4.81	No	No	0	8	7
18	R:R:I440	R:R:R61	7.52	No	No	0	8	7
19	R:R:E62	R:R:L65	5.3	No	Yes	0	8	9
20	R:R:A436	R:R:E62	4.53	No	No	0	9	8
21	R:R:E62	R:R:K439	4.05	No	No	0	8	7
22	R:R:A64	R:R:E432	6.03	No	No	0	7	7
23	R:R:L65	R:R:N70	5.49	Yes	Yes	1	9	9
24	R:R:E432	R:R:L65	6.63	No	Yes	0	7	9
25	R:R:F433	R:R:L65	7.31	Yes	Yes	1	9	9
26	R:R:T67	R:R:Y142	7.49	No	Yes	1	8	8
27	R:R:N143	R:R:T67	4.39	No	No	1	7	8
28	R:R:D131	R:R:T68	11.56	Yes	Yes	1	8	7
29	R:R:S148	R:R:T68	3.2	No	Yes	1	6	7
30	R:R:R151	R:R:T68	7.76	No	Yes	1	8	7
31	R:R:T68	R:R:V152	3.17	Yes	Yes	0	7	7
32	R:R:D131	R:R:T69	5.78	Yes	No	1	8	8
33	R:R:T69	R:R:Y142	4.99	No	Yes	1	8	8
34	R:R:F433	R:R:N70	6.04	Yes	Yes	1	9	9
35	R:R:A127	R:R:L72	3.15	No	No	0	7	8
36	R:R:I128	R:R:L72	5.71	No	No	0	9	8
37	R:R:N124	R:R:S75	4.47	No	No	0	8	9
38	R:R:I156	R:R:S75	6.19	No	No	0	9	9
39	R:R:L76	R:R:N124	4.12	Yes	No	0	9	8
40	R:R:L125	R:R:L76	4.15	Yes	Yes	3	8	9
41	R:R:L76	R:R:N422	4.12	Yes	Yes	3	9	9
42	R:R:D80	R:R:S121	4.42	No	No	0	9	9
43	R:R:D80	R:R:S419	11.78	No	No	0	9	9
44	R:R:L82	R:R:L86	5.54	No	No	0	7	5
45	R:R:L82	R:R:M117	9.9	No	No	0	7	7
46	R:R:M117	R:R:V83	4.56	No	No	0	7	8
47	R:R:F110	R:R:V87	5.24	Yes	No	0	7	8
48	R:R:D114	R:R:V87	5.84	No	No	0	8	8
49	R:R:M88	R:R:P89	3.35	Yes	No	0	9	9
50	R:R:M88	R:R:W413	10.47	Yes	Yes	0	9	8
51	R:R:M88	R:R:Y416	10.78	Yes	Yes	0	9	8
52	R:R:W100	R:R:W90	7.5	Yes	No	4	9	6
53	R:R:H106	R:R:W90	14.81	No	No	4	6	6
54	R:R:F110	R:R:W90	8.02	Yes	No	0	7	6
55	R:R:F110	R:R:V91	3.93	Yes	No	0	7	8
56	R:R:V91	R:R:W413	4.9	No	Yes	0	8	8
57	R:R:V97	R:R:Y93	10.09	Yes	No	0	5	6
58	R:R:W100	R:R:Y93	6.75	Yes	No	0	9	6
59	R:R:L94	R:R:W100	6.83	No	Yes	0	7	9
60	R:R:E95	R:R:S409	4.31	No	No	0	7	6
61	R:R:V96	R:R:V97	3.21	No	Yes	5	6	5
62	R:R:G98	R:R:V97	3.68	No	Yes	0	5	5
63	R:R:E99	R:R:N180	3.94	No	No	0	4	3
64	R:R:F102	R:R:W100	14.03	No	Yes	0	7	9
65	R:R:H106	R:R:W100	6.35	No	Yes	4	6	9
66	R:R:C107	R:R:W100	5.22	No	Yes	4	9	9
67	R:R:C182	R:R:W100	6.53	No	Yes	4	9	9
68	R:R:K101	R:R:Q179	4.07	No	No	0	4	1
69	R:R:Q179	R:R:R104	8.18	No	No	0	1	3
70	R:R:F172	R:R:I105	5.02	No	No	0	6	4
71	R:R:C107	R:R:C182	7.28	No	No	4	9	9
72	R:R:D108	R:R:N175	6.73	No	No	0	6	7
73	L:L:?1	R:R:F110	3.82	Yes	Yes	0	0	7
74	R:R:S167	R:R:T112	3.2	No	No	0	9	8
75	R:R:L171	R:R:T112	7.37	No	No	0	7	8
76	R:R:D114	R:R:Y416	12.64	No	Yes	2	8	8
77	L:L:?1	R:R:D114	15.32	Yes	No	2	0	8
78	L:L:?1	R:R:V115	8.41	Yes	No	0	0	8
79	R:R:M116	R:R:S163	4.6	No	No	0	7	8
80	R:R:F164	R:R:M116	9.95	No	No	0	6	7
81	R:R:M116	R:R:S167	6.13	No	No	0	7	9
82	R:R:M117	R:R:W160	4.65	No	No	0	7	9
83	R:R:C118	R:R:W386	6.53	No	No	0	8	9
84	L:L:?1	R:R:C118	5.97	Yes	No	0	0	8
85	R:R:S163	R:R:T119	3.2	No	No	0	8	8
86	R:R:S197	R:R:T119	9.59	No	No	2	8	8
87	L:L:?1	R:R:T119	3.7	Yes	No	2	0	8
88	R:R:A120	R:R:W160	6.48	No	No	0	8	9
89	R:R:A120	R:R:S163	3.42	No	No	0	8	8
90	R:R:I122	R:R:P201	3.39	No	Yes	0	9	9
91	R:R:F382	R:R:I122	6.28	No	No	0	9	9
92	R:R:L123	R:R:V159	4.47	No	No	0	8	9
93	R:R:L123	R:R:L162	5.54	No	No	0	8	7
94	R:R:L123	R:R:P201	3.28	No	Yes	0	8	9
95	R:R:N124	R:R:V159	10.35	No	No	0	8	9
96	R:R:F382	R:R:L125	3.65	No	Yes	0	9	8
97	R:R:L125	R:R:N422	5.49	Yes	Yes	3	8	9
98	R:R:L125	R:R:Y426	4.69	Yes	Yes	3	8	9
99	R:R:C126	R:R:P201	3.77	No	Yes	0	7	9
100	R:R:C126	R:R:V204	3.42	No	No	0	7	8
101	R:R:C126	R:R:I205	3.27	No	No	0	7	9
102	R:R:A127	R:R:M155	4.83	No	No	0	7	8
103	R:R:I128	R:R:R132	3.76	No	No	0	9	9
104	R:R:I205	R:R:S129	6.19	No	No	0	9	9
105	R:R:S129	R:R:V208	3.23	No	No	0	9	7
106	R:R:S129	R:R:Y209	11.45	No	Yes	0	9	9
107	R:R:D131	R:R:Y142	9.2	Yes	Yes	1	8	8
108	R:R:D131	R:R:R151	7.15	Yes	No	1	8	8
109	R:R:R132	R:R:Y209	6.17	No	Yes	3	9	9
110	R:R:R132	R:R:Y378	7.2	No	Yes	3	9	9
111	R:R:A137	R:R:Y133	9.34	No	No	0	8	8
112	R:R:K211	R:R:Y133	9.55	No	No	0	7	8
113	R:R:A135	R:R:Y142	5.34	No	Yes	0	8	8
114	R:R:N143	R:R:Y142	11.63	No	Yes	1	7	8
115	R:R:S147	R:R:T144	3.2	No	No	0	8	7
116	R:R:R145	R:R:Y146	17.49	No	No	0	7	8
117	R:R:R151	R:R:S148	7.91	No	No	1	8	6
118	R:R:L162	R:R:V196	4.47	No	No	0	7	6
119	R:R:I166	R:R:S193	7.74	No	No	0	8	9
120	R:R:C168	R:R:P169	3.77	No	No	0	6	8
121	R:R:C168	R:R:L171	3.17	No	No	0	6	7
122	R:R:F189	R:R:L170	10.96	No	No	0	8	8
123	R:R:A177	R:R:N175	6.25	No	No	0	4	7
124	R:R:I184	R:R:N175	7.08	No	No	0	7	7
125	R:R:N176	R:R:N186	6.81	No	Yes	0	7	7
126	R:R:D178	R:R:N180	4.04	No	No	0	3	3
127	R:R:E181	R:R:I183	13.66	No	No	0	4	5
128	L:L:?1	R:R:I183	8.95	Yes	No	0	0	5
129	L:L:?1	R:R:I184	3.58	Yes	No	0	0	7
130	R:R:N186	R:R:P187	3.26	Yes	No	0	7	4
131	R:R:F189	R:R:N186	3.62	No	Yes	0	8	7
132	R:R:I397	R:R:P187	3.39	No	No	0	6	4
133	R:R:F189	R:R:S193	5.28	No	No	0	8	9
134	R:R:H393	R:R:V190	13.84	Yes	No	0	8	7
135	R:R:I397	R:R:V191	6.14	No	No	0	6	7
136	R:R:S194	R:R:Y199	7.63	No	No	0	8	7
137	R:R:F390	R:R:S194	7.93	Yes	No	0	8	8
138	L:L:?1	R:R:S197	3.77	Yes	No	2	0	8
139	R:R:F198	R:R:Y199	9.28	Yes	No	0	9	7
140	R:R:F198	R:R:F202	3.22	Yes	No	0	9	7
141	R:R:F198	R:R:L387	4.87	Yes	No	0	9	7
142	R:R:F198	R:R:F390	26.79	Yes	Yes	0	9	8
143	R:R:I394	R:R:Y199	3.63	No	No	0	7	7
144	R:R:P201	R:R:V200	3.53	Yes	No	0	9	8
145	R:R:F202	R:R:I203	3.77	No	No	0	7	4
146	R:R:F202	R:R:I383	7.54	No	No	0	7	7
147	R:R:I210	R:R:L206	4.28	No	No	0	4	6
148	R:R:L375	R:R:Y209	5.86	No	Yes	0	8	9
149	R:R:Y209	R:R:Y378	6.95	Yes	Yes	3	9	9
150	R:R:L379	R:R:Y209	8.21	No	Yes	0	8	9
151	R:R:I212	R:R:L375	5.71	No	No	0	9	8
152	R:R:R217	R:R:Y213	8.23	No	No	0	6	7
153	R:R:T372	R:R:Y213	8.74	No	No	0	8	7
154	R:R:L216	R:R:R220	7.29	No	Yes	0	8	6
155	R:R:K221	R:R:R217	7.43	No	No	0	7	6
156	R:R:E368	R:R:R217	4.65	No	No	0	9	6
157	R:R:K367	R:R:R220	9.9	No	Yes	0	7	6
158	R:R:E368	R:R:R220	3.49	No	Yes	0	9	6
159	R:R:T225	R:R:V223	7.93	No	No	0	5	5
160	R:R:S364	R:R:T225	4.8	No	No	0	6	5
161	R:R:L363	R:R:Q366	5.32	No	No	0	5	6
162	R:R:K370	R:R:Q366	4.07	No	No	0	9	6
163	R:R:E368	R:R:K369	4.05	No	No	0	9	7
164	R:R:K370	R:R:L374	4.23	No	No	0	9	9
165	R:R:L374	R:R:Y378	5.86	No	Yes	0	9	9
166	R:R:F429	R:R:L374	9.74	No	No	0	8	9
167	R:R:I377	R:R:I425	4.42	No	Yes	0	8	8
168	R:R:I425	R:R:Y378	6.04	Yes	Yes	3	8	9
169	R:R:Y378	R:R:Y426	29.79	Yes	Yes	3	9	9
170	R:R:I421	R:R:L381	4.28	No	No	0	7	7
171	R:R:F382	R:R:I383	3.77	No	No	0	9	7
172	R:R:I383	R:R:L387	4.28	No	No	0	7	7
173	R:R:C385	R:R:N418	6.3	No	No	0	9	9
174	R:R:G415	R:R:W386	11.26	No	No	0	8	9
175	R:R:N418	R:R:W386	7.91	No	No	0	9	9
176	R:R:I391	R:R:L387	7.14	No	No	0	7	7
177	R:R:F411	R:R:P388	13	No	No	0	5	9
178	R:R:L414	R:R:P388	3.28	No	No	0	8	9
179	R:R:F389	R:R:F390	9.65	No	Yes	2	8	8
180	R:R:F389	R:R:Y408	4.13	No	Yes	2	8	5
181	L:L:?1	R:R:F389	10.69	Yes	No	2	0	8
182	L:L:?1	R:R:F390	6.87	Yes	Yes	2	0	8
183	R:R:I403	R:R:T392	4.56	Yes	No	0	6	5
184	R:R:F411	R:R:T392	3.89	No	No	0	5	5
185	R:R:H393	R:R:I397	6.63	Yes	No	0	8	6
186	R:R:H393	R:R:Y408	8.71	Yes	Yes	2	8	5
187	L:L:?1	R:R:H393	3.22	Yes	Yes	2	0	8
188	R:R:H398	R:R:I394	3.98	No	No	0	6	7
189	R:R:C399	R:R:L395	4.76	No	No	0	6	7
190	R:R:I403	R:R:N396	9.91	Yes	No	0	6	5
191	R:R:C399	R:R:C401	5.46	No	No	0	6	7
192	R:R:I403	R:R:P404	3.39	Yes	No	0	6	6
193	R:R:I403	R:R:Y408	9.67	Yes	Yes	0	6	5
194	R:R:P404	R:R:V406	3.53	No	No	0	6	4
195	R:R:F411	R:R:L407	3.65	No	No	0	5	6
196	L:L:?1	R:R:Y408	12.5	Yes	Yes	2	0	5
197	R:R:T412	R:R:Y416	4.99	No	Yes	2	8	8
198	L:L:?1	R:R:T412	7.39	Yes	No	2	0	8
199	L:L:?1	R:R:Y416	4.41	Yes	Yes	2	0	8
200	R:R:N418	R:R:N422	13.62	No	Yes	0	9	9
201	R:R:I421	R:R:I425	4.42	No	Yes	0	7	8
202	R:R:N422	R:R:Y426	6.98	Yes	Yes	3	9	9
203	R:R:I425	R:R:Y426	6.04	Yes	Yes	3	8	9
204	R:R:F433	R:R:T427	7.78	Yes	Yes	0	9	8
205	R:R:F437	R:R:T427	3.89	No	Yes	0	9	8
206	R:R:E432	R:R:N430	3.94	No	No	0	7	9
207	R:R:F433	R:R:N430	6.04	Yes	No	0	9	9
208	R:R:I431	R:R:K435	5.82	No	No	0	5	6
209	R:R:C443	R:R:L438	3.17	No	No	0	9	5
210	R:R:T427	R:R:T428	3.14	Yes	No	0	8	7
211	R:R:A38	R:R:N35	3.13	No	No	0	7	7
212	R:R:I184	R:R:V111	3.07	No	No	0	7	6
213	R:R:I156	R:R:V152	3.07	No	Yes	0	9	7
214	R:R:I158	R:R:V154	3.07	No	No	0	4	3
215	R:R:I421	R:R:V417	3.07	No	No	0	7	6
216	R:R:I424	R:R:T428	3.04	No	No	0	7	7
217	R:R:A38	R:R:E95	3.02	No	No	0	7	7
218	R:R:L76	R:R:S121	3	Yes	No	0	9	9
219	R:R:L81	R:R:V49	2.98	No	No	0	8	7
220	R:R:L54	R:R:V53	2.98	Yes	No	0	8	6
221	R:R:L86	R:R:T85	2.95	No	No	0	5	6
222	R:R:I210	R:R:I214	2.94	No	No	0	4	5
223	R:R:N70	R:R:T67	2.92	Yes	No	1	9	8
224	R:R:N70	R:R:T69	2.92	Yes	No	1	9	8
225	R:R:I130	R:R:M155	2.92	No	No	0	7	8
226	R:R:I109	R:R:L113	2.85	No	No	0	6	6
227	R:R:I203	R:R:L207	2.85	No	No	0	4	5
228	R:R:I212	R:R:L216	2.85	No	No	0	9	8
229	R:R:L141	R:R:M138	2.83	No	No	0	6	6
230	R:R:A58	R:R:F433	2.77	No	Yes	0	9	9
231	R:R:L206	R:R:L379	2.77	No	No	0	6	8
232	R:R:A371	R:R:R220	2.77	No	Yes	0	9	6
233	R:R:F433	R:R:V59	2.62	Yes	No	0	9	8
234	R:R:R219	R:R:V215	2.62	No	No	0	8	7
235	R:R:D178	R:R:Q179	2.61	No	No	0	3	1
236	R:R:A79	R:R:W160	2.59	No	No	0	8	9
237	R:R:V191	R:R:Y192	2.52	No	No	0	7	7
238	R:R:I105	R:R:R104	2.51	No	No	0	4	3
239	R:R:T144	R:R:Y146	2.5	No	No	0	7	8
240	R:R:S409	R:R:W413	2.47	No	Yes	0	6	8
241	R:R:V92	R:R:W413	2.45	No	Yes	0	8	8
242	R:R:I73	R:R:Y426	2.42	No	Yes	0	8	9
243	R:R:N226	R:R:R361	2.41	No	No	0	5	6
244	R:R:P404	R:R:P405	1.95	No	No	0	6	3
245	R:R:G380	R:R:I384	1.76	No	No	0	7	5
246	R:R:C56	R:R:V74	1.71	No	No	0	7	7
247	R:R:C56	R:R:V78	1.71	No	No	0	7	7
248	R:R:G380	R:R:L379	1.71	No	No	0	7	8
249	R:R:A46	R:R:V49	1.7	No	No	0	5	7
250	R:R:A420	R:R:V47	1.7	No	No	0	7	5
251	R:R:A135	R:R:V136	1.7	No	No	0	8	8
252	R:R:A137	R:R:V136	1.7	No	No	0	8	8
253	R:R:M138	R:R:P139	1.68	No	No	0	6	9
254	R:R:L174	R:R:P169	1.64	No	No	0	7	8
255	R:R:S147	R:R:S148	1.63	No	No	0	8	6
256	R:R:A420	R:R:I48	1.62	No	Yes	0	7	8
257	R:R:C56	R:R:M57	1.62	No	No	0	7	5
258	R:R:A58	R:R:I440	1.62	No	No	0	9	8
259	R:R:A436	R:R:I440	1.62	No	No	0	9	8
260	R:R:A137	R:R:M138	1.61	No	No	0	8	6
261	R:R:T39	R:R:V96	1.59	No	No	0	6	6
262	R:R:T153	R:R:V152	1.59	No	Yes	0	5	7
263	R:R:T165	R:R:V161	1.59	No	No	0	5	5
264	R:R:C401	R:R:N396	1.57	No	No	0	7	5
265	R:R:A185	R:R:N176	1.56	No	No	0	7	7
266	R:R:A188	R:R:N186	1.56	No	Yes	0	5	7
267	R:R:I158	R:R:S157	1.55	No	No	0	4	5
268	R:R:I195	R:R:V200	1.54	No	No	0	6	8
269	R:R:I45	R:R:T42	1.52	No	No	0	8	4
270	R:R:I130	R:R:T134	1.52	No	No	0	7	6
271	R:R:F172	R:R:G173	1.51	No	No	0	6	7
272	R:R:K149	R:R:T153	1.5	No	No	0	6	5
273	R:R:L113	R:R:V87	1.49	No	No	0	6	8
274	R:R:I431	R:R:N430	1.42	No	No	0	5	9
275	R:R:H106	R:R:S103	1.39	No	No	0	6	8
276	R:R:L40	R:R:L41	1.38	No	No	0	5	7
277	R:R:L441	R:R:L54	1.38	No	Yes	0	8	8
278	R:R:K63	R:R:Q66	1.36	No	No	0	8	8
279	R:R:K369	R:R:Q373	1.36	No	No	0	7	8
280	R:R:R150	R:R:V154	1.31	No	No	0	6	3
281	R:R:E181	R:R:N180	1.31	No	No	0	4	3
282	R:R:R218	R:R:V215	1.31	No	No	0	6	7
283	R:R:V59	R:R:Y71	1.26	No	No	0	8	7
284	R:R:V152	R:R:Y71	1.26	Yes	No	0	7	7
285	R:R:L222	R:R:R218	1.21	No	No	0	6	6
286	R:R:Q66	R:R:Y71	1.13	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I48	3.785	4	0	8
2	R:R:N52	9.2825	4	0	9
3	R:R:L54	3.22	4	0	8
4	R:R:L65	6.1825	4	1	9
5	R:R:T68	6.4225	4	1	7
6	R:R:N70	4.3425	4	1	9
7	R:R:L76	3.8475	4	3	9
8	R:R:M88	7.6075	4	0	9
9	R:R:V97	5.5075	4	5	5
10	R:R:W100	7.60143	7	4	9
11	R:R:F110	5.2525	4	0	7
12	R:R:L125	4.495	4	3	8
13	R:R:D131	8.4225	4	1	8
14	R:R:Y142	7.73	5	1	8
15	R:R:V152	2.2725	4	0	7
16	R:R:N186	3.8125	4	0	7
17	R:R:F198	11.04	4	0	9
18	R:R:P201	3.4925	4	0	9
19	R:R:Y209	7.728	5	3	9
20	R:R:R220	5.8625	4	0	6
21	R:R:Y378	11.168	5	3	9
22	R:R:F390	12.81	4	2	8
23	R:R:H393	8.1	4	2	8
24	R:R:I403	6.8825	4	0	6
25	R:R:Y408	8.7525	4	2	5
26	R:R:W413	6.564	5	0	8
27	R:R:Y416	8.205	4	2	8
28	R:R:N422	7.5525	4	3	9
29	R:R:I425	5.23	4	3	8
30	R:R:Y426	9.984	5	3	9
31	R:R:T427	4.495	4	0	8
32	R:R:F433	5.42667	6	1	9
33	L:L:?1	7.04286	14	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E95	R:R:S409	12.6736	4.31	No	No	0	7	6
2	R:R:S409	R:R:W413	15.5221	2.47	No	Yes	0	6	8
3	R:R:V91	R:R:W413	14.8277	4.9	No	Yes	0	8	8
4	R:R:F110	R:R:V91	16.2359	3.93	Yes	No	0	7	8
5	R:R:F110	R:R:W90	24.6978	8.02	Yes	No	0	7	6
6	R:R:W100	R:R:W90	19.7531	7.5	Yes	No	4	9	6
7	R:R:W100	R:R:Y93	11.8699	6.75	Yes	No	0	9	6
8	R:R:V97	R:R:Y93	10.1916	10.09	Yes	No	0	5	6
9	R:R:M88	R:R:W413	14.0625	10.47	Yes	Yes	0	9	8
10	R:R:M88	R:R:Y416	20.0103	10.78	Yes	Yes	0	9	8
11	L:L:?1	R:R:Y416	21.1741	4.41	Yes	Yes	2	0	8
12	L:L:?1	R:R:F110	43.2742	3.82	Yes	Yes	0	0	7
13	R:R:I48	R:R:N52	14.2168	5.66	Yes	Yes	0	8	9
14	R:R:D80	R:R:N52	22.0615	12.12	No	Yes	0	9	9
15	R:R:D80	R:R:S121	25.9066	4.42	No	No	0	9	9
16	R:R:L76	R:R:S121	27.8099	3	Yes	No	0	9	9
17	R:R:L76	R:R:N422	83.1019	4.12	Yes	Yes	3	9	9
18	R:R:N418	R:R:N422	96.2706	13.62	No	Yes	0	9	9
19	R:R:N418	R:R:W386	96.1163	7.91	No	No	0	9	9
20	R:R:C118	R:R:W386	96.0391	6.53	No	No	0	8	9
21	L:L:?1	R:R:C118	95.8591	5.97	Yes	No	0	0	8
22	R:R:F437	R:R:T427	10.4167	3.89	No	Yes	0	9	8
23	R:R:F433	R:R:T427	18.7307	7.78	Yes	Yes	0	9	8
24	R:R:F433	R:R:V59	45.8655	2.62	Yes	No	0	9	8
25	R:R:V59	R:R:Y71	53.1572	1.26	No	No	0	8	7
26	R:R:V152	R:R:Y71	57.9411	1.26	Yes	No	0	7	7
27	R:R:I156	R:R:V152	96.0391	3.07	No	Yes	0	9	7
28	R:R:I156	R:R:S75	97.3315	6.19	No	No	0	9	9
29	R:R:N124	R:R:S75	98.6111	4.47	No	No	0	8	9
30	R:R:L76	R:R:N124	100	4.12	Yes	No	0	9	8
31	R:R:F433	R:R:L65	10.7575	7.31	Yes	Yes	1	9	9
32	R:R:F433	R:R:N430	10.0116	6.04	Yes	No	0	9	9
33	R:R:D131	R:R:T68	25.1543	11.56	Yes	Yes	1	8	7
34	R:R:T68	R:R:V152	36.5934	3.17	Yes	Yes	0	7	7
35	R:R:D131	R:R:Y142	19.6952	9.2	Yes	Yes	1	8	8
36	R:R:S148	R:R:T68	10.4102	3.2	No	Yes	1	6	7
37	R:R:I128	R:R:L72	11.0854	5.71	No	No	0	9	8
38	R:R:I128	R:R:R132	13.2652	3.76	No	No	0	9	9
39	R:R:R132	R:R:Y378	13.831	7.2	No	Yes	3	9	9
40	R:R:Y378	R:R:Y426	68.287	29.79	Yes	Yes	3	9	9
41	R:R:N422	R:R:Y426	54.0059	6.98	Yes	Yes	3	9	9
42	R:R:A120	R:R:W160	12.3714	6.48	No	No	0	8	9
43	R:R:A120	R:R:S163	14.0882	3.42	No	No	0	8	8
44	R:R:S163	R:R:T119	28.9609	3.2	No	No	0	8	8
45	L:L:?1	R:R:T119	30.2919	3.7	Yes	No	2	0	8
46	R:R:E181	R:R:N180	15.7922	1.31	No	No	0	4	3
47	R:R:E181	R:R:I183	17.4833	13.66	No	No	0	4	5
48	L:L:?1	R:R:I183	18.9429	8.95	Yes	No	0	0	5
49	R:R:D178	R:R:Q179	10.6417	2.61	No	No	0	3	1
50	R:R:D178	R:R:N180	12.3714	4.04	No	No	0	3	3
51	R:R:M116	R:R:S167	10.6417	6.13	No	No	0	7	9
52	R:R:M116	R:R:S163	14.0882	4.6	No	No	0	7	8
53	R:R:F382	R:R:I122	20.3575	6.28	No	No	0	9	9
54	R:R:F382	R:R:I383	35.3974	3.77	No	No	0	9	7
55	R:R:F202	R:R:I383	18.6214	7.54	No	No	0	7	7
56	R:R:F198	R:R:F202	18.6214	3.22	Yes	No	0	9	7
57	R:R:F198	R:R:F390	30.9735	26.79	Yes	Yes	0	9	8
58	L:L:?1	R:R:F390	29.411	6.87	Yes	Yes	2	0	8
59	R:R:I383	R:R:L387	17.7341	4.28	No	No	0	7	7
60	R:R:F198	R:R:L387	17.7341	4.87	Yes	No	0	9	7
61	R:R:I122	R:R:P201	18.3835	3.39	No	Yes	0	9	9
62	R:R:N124	R:R:V159	10.3138	10.35	No	No	0	8	9
63	R:R:L123	R:R:P201	10.8475	3.28	No	Yes	0	8	9
64	R:R:C126	R:R:P201	10.0566	3.77	No	Yes	0	7	9
65	R:R:Y209	R:R:Y378	44.8174	6.95	Yes	Yes	3	9	9
66	R:R:A137	R:R:V136	13.1494	1.7	No	No	0	8	8
67	R:R:A135	R:R:V136	15.2971	1.7	No	No	0	8	8
68	R:R:A135	R:R:Y142	17.4318	5.34	No	Yes	0	8	8
69	R:R:N186	R:R:P187	13.9403	3.26	Yes	No	0	7	4
70	R:R:I397	R:R:P187	15.4514	3.39	No	No	0	6	4
71	R:R:H393	R:R:I397	20.5118	6.63	Yes	No	0	8	6
72	L:L:?1	R:R:H393	22.0679	3.22	Yes	Yes	2	0	8
73	R:R:L379	R:R:Y209	13.3359	8.21	No	Yes	0	8	9
74	R:R:L375	R:R:Y209	27.7778	5.86	No	Yes	0	8	9
75	R:R:I212	R:R:L375	25.6494	5.71	No	No	0	9	8
76	R:R:E368	R:R:R220	15.2971	3.49	No	Yes	0	9	6
77	R:R:L216	R:R:R220	21.4056	7.29	No	Yes	0	8	6
78	R:R:I212	R:R:L216	23.534	2.85	No	No	0	9	8
79	R:R:L374	R:R:Y378	11.4326	5.86	No	Yes	0	9	9
80	R:R:I403	R:R:T392	10.1209	4.56	Yes	No	0	6	5
81	R:R:I403	R:R:Y408	25.463	9.67	Yes	Yes	0	6	5
82	L:L:?1	R:R:Y408	22.5823	12.5	Yes	Yes	2	0	5
83	R:R:L125	R:R:Y426	27.6427	4.69	Yes	Yes	3	8	9
84	R:R:L125	R:R:L76	32.9025	4.15	Yes	Yes	3	8	9
85	R:R:F382	R:R:L125	18.4478	3.65	No	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F110	R:R:V87	5.24	0	Yes	No	7	8	1	2
R:R:D114	R:R:V87	5.84	2	No	No	8	8	1	2
R:R:M88	R:R:Y416	10.78	0	Yes	Yes	9	8	2	1
R:R:F110	R:R:W90	8.02	0	Yes	No	7	6	1	2
R:R:F110	R:R:V91	3.93	0	Yes	No	7	8	1	2
L:L:?1	R:R:F110	3.82	2	Yes	Yes	0	7	0	1
R:R:D114	R:R:Y416	12.64	2	No	Yes	8	8	1	1
L:L:?1	R:R:D114	15.32	2	Yes	No	0	8	0	1
L:L:?1	R:R:V115	8.41	2	Yes	No	0	8	0	1
R:R:C118	R:R:W386	6.53	0	No	No	8	9	1	2
L:L:?1	R:R:C118	5.97	2	Yes	No	0	8	0	1
R:R:S163	R:R:T119	3.2	0	No	No	8	8	2	1
R:R:S197	R:R:T119	9.59	2	No	No	8	8	1	1
L:L:?1	R:R:T119	3.7	2	Yes	No	0	8	0	1
R:R:I184	R:R:N175	7.08	0	No	No	7	7	1	2
R:R:E181	R:R:I183	13.66	0	No	No	4	5	2	1
L:L:?1	R:R:I183	8.95	2	Yes	No	0	5	0	1
L:L:?1	R:R:I184	3.58	2	Yes	No	0	7	0	1
R:R:H393	R:R:V190	13.84	2	Yes	No	8	7	1	2
R:R:F390	R:R:S194	7.93	2	Yes	No	8	8	1	2
L:L:?1	R:R:S197	3.77	2	Yes	No	0	8	0	1
R:R:F198	R:R:F390	26.79	0	Yes	Yes	9	8	2	1
R:R:F389	R:R:F390	9.65	2	No	Yes	8	8	1	1
R:R:F389	R:R:Y408	4.13	2	No	Yes	8	5	1	1
L:L:?1	R:R:F389	10.69	2	Yes	No	0	8	0	1
L:L:?1	R:R:F390	6.87	2	Yes	Yes	0	8	0	1
R:R:H393	R:R:I397	6.63	2	Yes	No	8	6	1	2
R:R:H393	R:R:Y408	8.71	2	Yes	Yes	8	5	1	1
L:L:?1	R:R:H393	3.22	2	Yes	Yes	0	8	0	1
R:R:I403	R:R:Y408	9.67	0	Yes	Yes	6	5	2	1
L:L:?1	R:R:Y408	12.5	2	Yes	Yes	0	5	0	1
R:R:T412	R:R:Y416	4.99	2	No	Yes	8	8	1	1
L:L:?1	R:R:T412	7.39	2	Yes	No	0	8	0	1
L:L:?1	R:R:Y416	4.41	2	Yes	Yes	0	8	0	1
R:R:I184	R:R:V111	3.07	0	No	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6VMS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	264
Number of Links	286
Number of Hubs	33
Number of Links mediated by Hubs	125
Number of Communities	5
Number of Nodes involved in Communities	37
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	41391
Length Of Smallest Path	3
Average Path Length	12.9409
Length of Longest Path	27
Minimum Path Strength	1.195
Average Path Strength	6.31243
Maximum Path Strength	18.385
Minimum Path Correlation	0.7
Average Path Correlation	0.929963
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	51.5939
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9844
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • GTPase activating protein binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein localization to postsynaptic specialization membrane • protein localization to postsynaptic membrane • protein localization to cell periphery • cellular localization • protein localization to synapse • biological regulation • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • macromolecule localization • protein localization to organelle
Gene Ontology	Biological Process	• protein localization to postsynaptic specialization membrane • protein localization to postsynaptic membrane • protein localization to cell periphery • cellular localization • protein localization to synapse • biological regulation • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • macromolecule localization • protein localization to organelle • cellular process • protein localization to postsynapse • intracellular protein localization • regulation of biological quality • protein localization to cell junction • receptor localization to synapse • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • trans-synaptic signaling • regulation of signaling • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of biological process • cell-cell signaling • negative regulation of synaptic transmission • negative regulation of cell communication • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of cellular process • regulation of cell communication • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • synapse • cell junction • glutamatergic synapse • postsynapse • membrane-bounded organelle • nucleus • intracellular membrane-bounded organelle • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • cation binding • ion binding • catecholamine binding • dopamine binding • small molecule binding • G-protein alpha-subunit binding • potassium channel regulator activity • channel regulator activity • ion channel regulator activity • molecular function regulator activity • transporter regulator activity • heterotrimeric G-protein binding • heterocyclic compound binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • signaling receptor activity • identical protein binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • ionotropic glutamate receptor binding • signaling receptor binding • glutamate receptor binding • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to bacterium • response to stress • response to external stimulus • response to external biotic stimulus • response to biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • response to xenobiotic stimulus • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of protein localization • negative regulation of biological process • negative regulation of transport • protein localization to extracellular region • regulation of secretion by cell • secretion by cell • negative regulation of secretion • negative regulation of cellular process • negative regulation of secretion by cell • intracellular protein localization • negative regulation of protein localization • regulation of transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • autophagy • process utilizing autophagic mechanism • response to retinoic acid • cellular response to retinoic acid • response to toxic substance • cellular developmental process • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • cell differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • cell migration • cell motility • GABAergic neuron differentiation • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • response to metal ion • response to iron ion • regulation of biosynthetic process • rhythmic process • circadian regulation of gene expression • circadian rhythm • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • regulation of metabolic process • regulation of cellular response to hypoxia • cellular response to oxygen levels • cellular response to hypoxia • regulation of cellular response to stress • cellular response to decreased oxygen levels • cellular response to stress • regulation of response to stress • response to decreased oxygen levels • negative regulation of response to stimulus • negative regulation of cellular response to hypoxia • regulation of response to stimulus • response to hypoxia • response to oxygen levels • response to abiotic stimulus • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • biogenic amine metabolic process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of glial cell-derived neurotrophic factor production • positive regulation of gene expression • glial cell-derived neurotrophic factor production • positive regulation of multicellular organismal process • positive regulation of cytokine production • positive regulation of glial cell-derived neurotrophic factor production • regulation of potassium ion transport • regulation of monoatomic ion transport • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • cellular response to ethanol • response to ethanol • negative regulation of locomotion • regulation of cell motility • regulation of locomotion • regulation of cell migration • negative regulation of cell motility • negative regulation of cell migration • locomotion • negative regulation of signaling • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of cell communication • trans-synaptic signaling • regulation of signaling • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • negative regulation of synaptic transmission, glutamatergic • response to morphine • response to isoquinoline alkaloid • response to alkaloid • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • monoamine transport • positive regulation of dopamine uptake involved in synaptic transmission • import into cell • cellular localization • regulation of catecholamine uptake involved in synaptic transmission • organic hydroxy compound transport • dopamine transport • catecholamine uptake • positive regulation of amine transport • dopamine uptake involved in synaptic transmission • catecholamine transport • establishment of localization in cell • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • positive regulation of neurotransmitter transport • catecholamine uptake involved in synaptic transmission • regulation of neurotransmitter transport • neurotransmitter transport • amine transport • positive regulation of catecholamine uptake involved in synaptic transmission • positive regulation of transport • positive regulation of neurotransmitter uptake • neurotransmitter uptake • regulation of amine transport • synaptic transmission, dopaminergic • dopamine uptake • adult walking behavior • adult locomotory behavior • behavior • adult behavior • locomotory behavior • walking behavior • acid secretion • response to auditory stimulus • auditory behavior • response to mechanical stimulus • mechanosensory behavior • negative adaptation of signaling pathway • receptor internalization • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • vesicle-mediated transport • regulation of G protein-coupled receptor signaling pathway • G protein-coupled receptor internalization • negative regulation of signal transduction • adaptation of signaling pathway • receptor-mediated endocytosis • endocytosis • phospholipase C-activating dopamine receptor signaling pathway • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • neuron-neuron synaptic transmission • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • long-term synaptic potentiation • positive regulation of long-term synaptic potentiation • regulation of synaptic plasticity • positive regulation of synaptic transmission • regulation of long-term synaptic potentiation • morphogenesis of a branching structure • branching morphogenesis of a nerve • sensory perception of smell • regulation of catecholamine secretion • signal release • dopamine secretion • catecholamine secretion • regulation of dopamine secretion • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • negative regulation of hormone secretion • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • negative regulation of peptide secretion • peptide secretion • amide transport • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • cell surface receptor signaling pathway • excitatory postsynaptic potential • regulation of membrane potential • epithelial cell proliferation • renal sodium excretion • inorganic ion homeostasis • regulation of renal system process • homeostatic process • regulation of system process • positive regulation of secretion • monoatomic ion homeostasis • monoatomic cation homeostasis • positive regulation of renal sodium excretion • excretion • sodium ion homeostasis • renal tubular secretion • regulation of renal sodium excretion • chemical homeostasis • regulation of excretion • intracellular calcium ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • negative regulation of sequestering of calcium ion • calcium ion transport • maintenance of location in cell • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • intracellular chemical homeostasis • regulation of sequestering of calcium ion • intracellular monoatomic ion homeostasis • calcium ion transmembrane import into cytosol • sequestering of calcium ion • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • cellular homeostasis • calcium ion transmembrane transport • response to inactivity • multicellular organismal-level homeostasis • temperature homeostasis • learning • learning or memory • cognition • associative learning • response to amine • response to amphetamine • Wnt signaling pathway • negative regulation of neuron migration • regulation of neuron migration • regulation of sodium ion transport • sodium ion transport • grooming behavior • response to estradiol • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • neuroblast proliferation • neural precursor cell proliferation • heart process • regulation of heart contraction • regulation of blood circulation • heart contraction • regulation of heart rate • response to wounding • response to axon injury • endocrine system development • pituitary gland development • gland development • diencephalon development • adenohypophysis development • positive regulation of G protein-coupled receptor signaling pathway • regulation of cellular component organization • regulation of synapse structural plasticity • regulation of synapse organization • cell junction organization • regulation of synapse structure or activity • synapse organization • presynaptic modulation of chemical synaptic transmission • response to light stimulus • response to radiation • negative regulation of amine transport • negative regulation of dopamine secretion • negative regulation of catecholamine secretion • drinking behavior • feeding behavior • response to histamine • startle response • regulation of response to external stimulus • neuromuscular process • prepulse inhibition • negative regulation of response to external stimulus • regulation of neuronal synaptic plasticity • regulation of long-term neuronal synaptic plasticity • regulation of dopamine receptor signaling pathway • negative regulation of dopamine receptor signaling pathway • postsynaptic modulation of chemical synaptic transmission • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of intracellular signal transduction • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • pigmentation • striatum development • subpallium development • regulation of systemic arterial blood pressure • nervous system process involved in regulation of systemic arterial blood pressure • negative regulation of cell population proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • negative regulation of epithelial cell proliferation • cellular component biogenesis • cellular component assembly • cell junction assembly • synapse assembly • negative regulation of behavior • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • negative regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle • negative regulation of circadian rhythm • regulation of circadian rhythm • regulation of behavior • circadian behavior • sleep • negative regulation of multicellular organismal process • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • locomotion involved in locomotory behavior • regulation of locomotion involved in locomotory behavior • orbitofrontal cortex development • limbic system development • behavioral response to cocaine • response to cocaine • regulation of dephosphorylation • negative regulation of metabolic process • dephosphorylation • negative regulation of phosphate metabolic process • negative regulation of phosphorus metabolic process • phosphate-containing compound metabolic process • negative regulation of dephosphorylation • regulation of phosphorus metabolic process • phosphorus metabolic process • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • anatomical structure regression • hyaloid vascular plexus regression • positive regulation of cellular component organization • regulation of receptor internalization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • regulation of defense response • regulation of response to biotic stimulus • negative regulation of response to biotic stimulus • innate immune response • regulation of immune system process • immune response • regulation of innate immune response • negative regulation of immune response • defense response to symbiont • negative regulation of immune system process • immune system process • defense response to other organism • negative regulation of defense response • regulation of immune response • negative regulation of innate immune response • adenylate cyclase-inhibiting dopamine receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • visual learning • visual behavior • behavioral response to ethanol • long-term memory • memory • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of developmental growth • response to nicotine • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of peptide secretion • growth hormone secretion • regulation of growth hormone secretion • positive regulation of peptide hormone secretion • positive regulation of growth hormone secretion • positive regulation of nervous system development • positive regulation of cell population proliferation • regulation of neuroblast proliferation • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • regulation of multicellular organismal development • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region • other organism part • somatodendritic compartment • cell body • perikaryon • neuronal cell body • Golgi membrane • Golgi apparatus • endomembrane system • neuron spine • dendritic spine • dendrite • dendritic tree • acrosomal vesicle • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • GABA-ergic synapse • ciliary membrane • plasma membrane region • cell projection membrane • lateral plasma membrane • postsynaptic membrane • synaptic membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • receptor complex • 9+2 motile cilium • sperm flagellum • motile cilium • presynapse • presynaptic membrane • dopaminergic synapse • endocytic vesicle • transport vesicle membrane • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • exocytic vesicle • axon • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	08Y
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	08Y
Name	Bromocriptine
Synonyms	2-bromo-α-ergokryptine
Identifier
Formula	C32 H40 Br N5 O5
Molecular Weight	654.594
SMILES
PubChem	31101
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	6
Total Bonds	89
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P14416
Sequence	>6VMS_nogp_Chain_R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E K A L Q T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G E W K F S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M P M L Y N T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G L N N A D Q N E C I I A N P A F V V Y S S I V S F Y V P F I V I L L V Y I K I Y I V L R R R R K L V N T N R K L S Q Q K E K K A T Q L L A I Y L G L F I I C W L P F F I T H I L N I H C D C N I P P V L Y S A F T W L G Y V N S A I N P I I Y T T F N I E F R K A F L K I L H C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7JVR	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-	Gi1/β1/γ2	2.8	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVR (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-		2.8	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	doi.org/10.1038/nature25758
	8IRS	A	Amine	Dopamine	D₂	Homo sapiens	Rotigotine	-	Gi1/β1/γ2	3	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRS (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Rotigotine	-		3	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	6LUQ	A	Amine	Dopamine	D₂	Homo sapiens	Haloperidol	-	-	3.1	2020-03-04	doi.org/10.1038/s41467-020-14884-y
	7DFP	A	Amine	Dopamine	D₂	Homo sapiens	Spiperone	-	-	3.1	2020-12-30	doi.org/10.1038/s41467-020-20221-0
	6VMS	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-	Gi1/β1/γ2	3.8	2020-06-17	doi.org/10.1038/s41586-020-2379-5
	6VMS (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-		3.8	2020-06-17	doi.org/10.1038/s41586-020-2379-5
	8TZQ	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-	Go/β1/γ2	3.2	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8TZQ (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-		3.2	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8U02	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-	Go/β1/γ2	3.28	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8U02 (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-		3.28	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	8JD2	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	2.8	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8ZW0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ2	2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-		2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	7M8W	A	Lipid	Prostanoid	DP₂	Homo sapiens	15r-Methyl-Prostaglandin D2	Na	-	2.61	2021-08-25	doi.org/10.1073/pnas.2102813118
	6D26	A	Lipid	Prostanoid	DP₂	Homo sapiens	Fevipiprant	-	-	2.8	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009

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