psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D114	13.39	Yes	No	0	0	8
2	L:L:?1	R:R:V115	13.37	Yes	No	1	0	8
3	L:L:?1	R:R:C118	4.27	Yes	No	1	0	8
4	L:L:?1	R:R:S193	9.43	Yes	No	0	0	9
5	L:L:?1	R:R:S197	4.04	Yes	No	0	0	8
6	L:L:?1	R:R:W386	4.09	Yes	Yes	1	0	9
7	L:L:?1	R:R:F389	17.48	Yes	Yes	1	0	8
8	L:L:?1	R:R:F390	9.83	Yes	Yes	1	0	8
9	L:L:?1	R:R:H393	11.53	Yes	Yes	1	0	8
10	R:R:V96	R:R:Y36	3.79	No	No	0	6	5
11	R:R:V97	R:R:Y36	3.79	No	No	0	5	5
12	R:R:A38	R:R:V92	3.39	No	No	0	7	8
13	R:R:A38	R:R:V96	3.39	No	No	0	7	6
14	R:R:L41	R:R:W413	12.53	No	Yes	0	7	8
15	R:R:I48	R:R:L44	5.71	Yes	No	0	8	7
16	R:R:I45	R:R:M88	5.83	No	No	0	8	9
17	R:R:I45	R:R:P89	3.39	No	No	0	8	9
18	R:R:A84	R:R:I48	4.87	No	Yes	0	8	8
19	R:R:L81	R:R:V49	4.47	No	No	0	8	7
20	R:R:F50	R:R:L54	8.53	No	No	0	5	8
21	R:R:G51	R:R:P423	4.06	No	No	0	9	9
22	R:R:A77	R:R:N52	4.69	No	Yes	0	9	9
23	R:R:D80	R:R:N52	12.12	Yes	Yes	0	9	9
24	R:R:L81	R:R:N52	5.49	No	Yes	0	8	9
25	R:R:N52	R:R:P423	13.03	Yes	No	0	9	9
26	R:R:A77	R:R:V55	3.39	No	No	0	9	9
27	R:R:T427	R:R:V55	7.93	No	No	0	8	9
28	R:R:M57	R:R:R61	8.69	Yes	No	5	5	7
29	R:R:I440	R:R:M57	4.37	No	Yes	5	8	5
30	R:R:A58	R:R:F437	4.16	No	No	0	9	9
31	R:R:V59	R:R:V74	4.81	No	No	0	8	7
32	R:R:I440	R:R:R61	6.26	No	No	5	8	7
33	R:R:A64	R:R:E62	4.53	No	No	0	7	8
34	R:R:E62	R:R:L65	5.3	No	Yes	0	8	9
35	R:R:L65	R:R:N70	8.24	Yes	No	4	9	9
36	R:R:E432	R:R:L65	3.98	No	Yes	0	7	9
37	R:R:F433	R:R:L65	14.61	Yes	Yes	4	9	9
38	R:R:Q66	R:R:Y71	10.15	No	No	0	8	7
39	R:R:T67	R:R:T69	4.71	No	No	0	8	8
40	R:R:N70	R:R:T67	11.7	No	No	0	9	8
41	R:R:D131	R:R:T68	8.67	Yes	Yes	3	8	7
42	R:R:T68	R:R:Y142	4.99	Yes	Yes	3	7	8
43	R:R:S148	R:R:T68	4.8	No	Yes	0	6	7
44	R:R:D131	R:R:T69	4.34	Yes	No	3	8	8
45	R:R:T69	R:R:Y142	6.24	No	Yes	3	8	8
46	R:R:F433	R:R:N70	8.46	Yes	No	4	9	9
47	R:R:V152	R:R:Y71	3.79	No	No	0	7	7
48	R:R:D131	R:R:L72	4.07	Yes	No	3	8	8
49	R:R:L72	R:R:M155	4.24	No	No	3	8	8
50	R:R:I73	R:R:Y426	3.63	No	Yes	0	8	9
51	R:R:N124	R:R:S75	8.94	No	No	0	8	9
52	R:R:I156	R:R:S75	6.19	No	No	0	9	9
53	R:R:S75	R:R:W160	4.94	No	Yes	0	9	9
54	R:R:L76	R:R:N124	8.24	Yes	No	0	9	8
55	R:R:L125	R:R:L76	4.15	Yes	Yes	1	8	9
56	R:R:L76	R:R:N422	6.87	Yes	Yes	1	9	9
57	R:R:L76	R:R:Y426	3.52	Yes	Yes	1	9	9
58	R:R:D80	R:R:S121	5.89	Yes	No	0	9	9
59	R:R:D80	R:R:S419	11.78	Yes	No	0	9	9
60	R:R:D80	R:R:N422	6.73	Yes	Yes	0	9	9
61	R:R:L82	R:R:M117	5.65	No	Yes	0	7	7
62	R:R:V83	R:R:V87	4.81	No	No	0	8	8
63	R:R:M117	R:R:V83	4.56	Yes	No	0	7	8
64	R:R:L113	R:R:L86	4.15	No	No	0	6	5
65	R:R:F110	R:R:V87	5.24	No	No	0	7	8
66	R:R:D114	R:R:V87	7.3	No	No	0	8	8
67	R:R:M88	R:R:Y416	13.17	No	Yes	0	9	8
68	R:R:W90	R:R:Y93	11.58	Yes	No	2	6	6
69	R:R:W100	R:R:W90	4.69	Yes	Yes	2	9	6
70	R:R:F102	R:R:W90	9.02	No	Yes	2	7	6
71	R:R:H106	R:R:W90	25.39	No	Yes	2	6	6
72	R:R:F110	R:R:W90	5.01	No	Yes	2	7	6
73	R:R:V91	R:R:Y416	3.79	No	Yes	0	8	8
74	R:R:F102	R:R:Y93	4.13	No	No	2	7	6
75	R:R:L94	R:R:W100	6.83	No	Yes	0	7	9
76	R:R:E95	R:R:W413	8.72	No	Yes	0	7	8
77	R:R:K101	R:R:V97	4.55	No	No	0	4	5
78	R:R:E99	R:R:K101	9.45	No	No	0	4	4
79	R:R:E99	R:R:N180	11.83	No	No	0	4	3
80	R:R:F102	R:R:W100	17.04	No	Yes	2	7	9
81	R:R:H106	R:R:W100	7.41	No	Yes	2	6	9
82	R:R:C107	R:R:W100	18.28	No	Yes	2	9	9
83	R:R:F110	R:R:W100	7.02	No	Yes	2	7	9
84	R:R:C182	R:R:W100	9.14	No	Yes	2	9	9
85	R:R:H106	R:R:S103	4.18	No	No	0	6	8
86	R:R:A177	R:R:R104	6.91	No	No	0	4	3
87	R:R:C107	R:R:C182	7.28	No	No	2	9	9
88	R:R:D108	R:R:N175	8.08	No	No	0	6	7
89	R:R:L170	R:R:V111	5.96	Yes	No	0	8	6
90	R:R:L171	R:R:T112	11.79	No	No	0	7	8
91	R:R:D114	R:R:Y416	8.05	No	Yes	0	8	8
92	R:R:L170	R:R:V115	4.47	Yes	No	1	8	8
93	R:R:F189	R:R:V115	3.93	Yes	No	1	8	8
94	R:R:M116	R:R:M117	4.33	No	Yes	0	7	7
95	R:R:F164	R:R:M116	3.73	No	No	0	6	7
96	R:R:M116	R:R:S167	10.73	No	No	0	7	9
97	R:R:M117	R:R:W160	5.82	Yes	Yes	0	7	9
98	R:R:C118	R:R:W386	6.53	No	Yes	1	8	9
99	R:R:S197	R:R:T119	6.4	No	No	0	8	8
100	R:R:A120	R:R:W160	6.48	No	Yes	6	8	9
101	R:R:A120	R:R:S163	3.42	No	No	6	8	8
102	R:R:I122	R:R:P201	3.39	No	No	0	9	9
103	R:R:F382	R:R:I122	3.77	Yes	No	0	9	9
104	R:R:I122	R:R:W386	14.09	No	Yes	0	9	9
105	R:R:L123	R:R:V159	4.47	No	No	0	8	9
106	R:R:N124	R:R:V159	7.39	No	No	0	8	9
107	R:R:F382	R:R:L125	4.87	Yes	Yes	1	9	8
108	R:R:L125	R:R:N422	4.12	Yes	Yes	1	8	9
109	R:R:L125	R:R:Y426	7.03	Yes	Yes	1	8	9
110	R:R:C126	R:R:P201	3.77	No	No	0	7	9
111	R:R:I128	R:R:R132	5.01	No	No	1	9	9
112	R:R:I128	R:R:Y426	7.25	No	Yes	1	9	9
113	R:R:S129	R:R:T205	6.4	No	No	1	9	9
114	R:R:S129	R:R:V208	4.85	No	No	1	9	7
115	R:R:S129	R:R:Y209	16.53	No	Yes	1	9	9
116	R:R:I130	R:R:Y133	3.63	No	Yes	0	7	8
117	R:R:D131	R:R:Y142	9.2	Yes	Yes	3	8	8
118	R:R:D131	R:R:M155	4.16	Yes	No	3	8	8
119	R:R:R132	R:R:Y209	10.29	No	Yes	1	9	9
120	R:R:R132	R:R:Y426	4.12	No	Yes	1	9	9
121	R:R:A137	R:R:Y133	9.34	No	Yes	0	8	8
122	R:R:V208	R:R:Y133	3.79	No	Yes	1	7	8
123	R:R:K211	R:R:Y133	17.91	No	Yes	1	7	8
124	R:R:I212	R:R:Y133	6.04	No	Yes	0	9	8
125	R:R:M138	R:R:T134	4.52	Yes	No	0	6	6
126	R:R:A135	R:R:Y142	9.34	No	Yes	0	8	8
127	R:R:L141	R:R:M138	8.48	No	Yes	0	6	6
128	R:R:R145	R:R:Y146	5.14	No	No	0	7	8
129	R:R:I158	R:R:L162	5.71	No	No	0	4	7
130	R:R:S163	R:R:W160	3.71	No	Yes	6	8	9
131	R:R:C168	R:R:F164	5.59	No	No	0	6	6
132	R:R:I166	R:R:V196	9.22	No	No	0	8	6
133	R:R:F189	R:R:P169	7.22	Yes	No	0	8	8
134	R:R:L170	R:R:N175	6.87	Yes	No	0	8	7
135	R:R:I184	R:R:L170	4.28	No	Yes	1	7	8
136	R:R:F189	R:R:L170	19.49	Yes	Yes	1	8	8
137	R:R:F172	R:R:L171	3.65	No	No	0	6	7
138	R:R:L174	R:R:N186	8.24	No	Yes	0	7	7
139	R:R:F189	R:R:L174	4.87	Yes	No	0	8	7
140	R:R:D178	R:R:Q179	6.53	No	No	0	3	1
141	R:R:F189	R:R:I184	3.77	Yes	No	1	8	7
142	R:R:N186	R:R:P187	4.89	Yes	No	0	7	4
143	R:R:I397	R:R:P187	5.08	No	No	0	6	4
144	R:R:F189	R:R:S193	9.25	Yes	No	0	8	9
145	R:R:H393	R:R:V190	13.84	Yes	No	0	8	7
146	R:R:I397	R:R:V190	6.14	No	No	0	6	7
147	R:R:S194	R:R:Y199	6.36	No	No	0	8	7
148	R:R:F390	R:R:S194	7.93	Yes	No	0	8	8
149	R:R:I394	R:R:S194	6.19	No	No	0	7	8
150	R:R:F198	R:R:Y199	7.22	Yes	No	0	9	7
151	R:R:F198	R:R:F202	12.86	Yes	No	1	9	7
152	R:R:F198	R:R:F382	6.43	Yes	Yes	1	9	9
153	R:R:F198	R:R:W386	5.01	Yes	Yes	1	9	9
154	R:R:F198	R:R:L387	3.65	Yes	No	0	9	7
155	R:R:F198	R:R:F390	20.36	Yes	Yes	1	9	8
156	R:R:P201	R:R:V200	3.53	No	No	0	9	8
157	R:R:F202	R:R:F382	8.57	No	Yes	1	7	9
158	R:R:F202	R:R:I383	10.05	No	No	0	7	7
159	R:R:I203	R:R:L207	8.56	No	No	0	4	5
160	R:R:T205	R:R:Y209	3.75	No	Yes	1	9	9
161	R:R:I210	R:R:L206	5.71	No	No	0	4	6
162	R:R:L206	R:R:L379	11.07	No	No	0	6	8
163	R:R:K211	R:R:V208	4.55	No	No	1	7	7
164	R:R:L375	R:R:Y209	7.03	No	Yes	0	8	9
165	R:R:V378	R:R:Y209	8.83	No	Yes	0	9	9
166	R:R:I214	R:R:Y213	3.63	No	No	7	5	7
167	R:R:R217	R:R:Y213	19.55	No	No	7	6	7
168	R:R:T372	R:R:Y213	4.99	No	No	0	8	7
169	R:R:I214	R:R:R217	3.76	No	No	7	5	6
170	R:R:R218	R:R:V215	9.15	No	No	0	6	7
171	R:R:E368	R:R:L216	5.3	Yes	No	0	9	8
172	R:R:K221	R:R:R220	8.66	No	No	0	7	6
173	R:R:Q365	R:R:R220	11.68	No	No	0	5	6
174	R:R:E368	R:R:R220	12.79	Yes	No	0	9	6
175	R:R:K362	R:R:Q366	4.07	No	No	0	6	6
176	R:R:Q365	R:R:S364	5.78	No	No	0	5	6
177	R:R:E368	R:R:T372	4.23	Yes	No	0	9	8
178	R:R:K370	R:R:M374	4.32	No	No	0	9	9
179	R:R:F429	R:R:M374	14.93	No	No	0	8	9
180	R:R:V378	R:R:Y426	8.83	No	Yes	0	9	9
181	R:R:I383	R:R:L379	7.14	No	No	0	7	8
182	R:R:V381	R:R:V421	6.41	No	No	0	7	7
183	R:R:C385	R:R:N418	9.45	No	No	0	9	9
184	R:R:F390	R:R:W386	9.02	Yes	Yes	1	8	9
185	R:R:G415	R:R:W386	8.44	No	Yes	0	8	9
186	R:R:N418	R:R:W386	7.91	No	Yes	0	9	9
187	R:R:I391	R:R:L387	5.71	No	No	0	7	7
188	R:R:F411	R:R:P388	11.56	No	No	0	5	9
189	R:R:F389	R:R:F390	9.65	Yes	Yes	1	8	8
190	R:R:F389	R:R:H393	7.92	Yes	Yes	1	8	8
191	R:R:F389	R:R:Y408	4.13	Yes	No	1	8	5
192	R:R:F389	R:R:T412	7.78	Yes	No	0	8	8
193	R:R:I403	R:R:T392	4.56	Yes	No	0	6	5
194	R:R:F411	R:R:T392	6.49	No	No	0	5	5
195	R:R:H393	R:R:Y408	5.44	Yes	No	1	8	5
196	R:R:C401	R:R:L395	7.94	No	No	8	7	7
197	R:R:I403	R:R:L395	4.28	Yes	No	8	6	7
198	R:R:I403	R:R:N396	7.08	Yes	No	0	6	5
199	R:R:N396	R:R:Y408	6.98	No	No	0	5	5
200	R:R:C399	R:R:H398	4.42	No	No	0	6	6
201	R:R:C401	R:R:I403	4.91	No	Yes	8	7	6
202	R:R:P404	R:R:V406	3.53	Yes	No	0	6	4
203	R:R:L407	R:R:P404	4.93	No	Yes	0	6	6
204	R:R:F411	R:R:L407	9.74	No	No	0	5	6
205	R:R:S409	R:R:W413	3.71	No	Yes	0	6	8
206	R:R:T412	R:R:Y416	3.75	No	Yes	0	8	8
207	R:R:L414	R:R:V417	4.47	No	No	0	8	6
208	R:R:N418	R:R:N422	8.17	No	Yes	0	9	9
209	R:R:N422	R:R:Y426	4.65	Yes	Yes	1	9	9
210	R:R:I424	R:R:T428	10.64	No	No	0	7	7
211	R:R:I425	R:R:Y426	6.04	No	Yes	0	8	9
212	R:R:F433	R:R:T427	14.27	Yes	No	4	9	8
213	R:R:F437	R:R:T427	6.49	No	No	4	9	8
214	R:R:E432	R:R:N430	6.57	No	No	0	7	9
215	R:R:F433	R:R:N430	12.08	Yes	No	0	9	9
216	R:R:E432	R:R:I431	6.83	No	No	0	7	5
217	R:R:I431	R:R:R434	12.53	No	No	0	5	9
218	R:R:F433	R:R:F437	7.5	Yes	No	4	9	9
219	R:R:K435	R:R:K439	5.75	No	No	0	6	7
220	R:R:C443	R:R:L441	6.35	No	No	0	9	8
221	R:R:A420	R:R:I48	3.25	No	Yes	0	7	8
222	R:R:A127	R:R:M155	3.22	No	No	0	7	8
223	R:R:V136	R:R:V215	3.21	No	No	0	8	7
224	R:R:S167	R:R:T112	3.2	No	No	0	9	8
225	R:R:S147	R:R:T144	3.2	No	No	0	8	7
226	R:R:T68	R:R:V152	3.17	Yes	No	0	7	7
227	R:R:C385	R:R:L414	3.17	No	No	0	9	8
228	R:R:A188	R:R:N186	3.13	No	Yes	0	5	7
229	R:R:I48	R:R:S419	3.1	Yes	No	0	8	9
230	R:R:I166	R:R:S193	3.1	No	No	0	8	9
231	R:R:M57	R:R:S60	3.07	Yes	No	0	5	6
232	R:R:I195	R:R:V191	3.07	No	No	0	6	7
233	R:R:I425	R:R:V421	3.07	No	No	0	8	7
234	R:R:M57	R:R:V53	3.04	Yes	No	0	5	6
235	R:R:A38	R:R:E95	3.02	No	No	0	7	7
236	R:R:F50	R:R:G51	3.01	No	No	0	5	9
237	R:R:L81	R:R:V53	2.98	No	No	0	8	6
238	R:R:L82	R:R:V78	2.98	No	No	0	7	7
239	R:R:I105	R:R:I109	2.94	No	No	0	4	6
240	R:R:I377	R:R:I425	2.94	No	No	0	8	8
241	R:R:I377	R:R:M374	2.92	No	No	0	8	9
242	R:R:Q66	R:R:V59	2.87	No	No	0	8	8
243	R:R:I109	R:R:L113	2.85	No	No	0	6	6
244	R:R:L82	R:R:L86	2.77	No	No	0	7	5
245	R:R:L123	R:R:L162	2.77	No	No	0	8	7
246	R:R:K63	R:R:Q66	2.71	No	No	0	8	8
247	R:R:E368	R:R:K369	2.7	Yes	No	0	9	7
248	R:R:L363	R:R:Q366	2.66	No	No	0	5	6
249	R:R:R151	R:R:S147	2.64	No	No	0	8	8
250	R:R:A79	R:R:W160	2.59	No	Yes	0	8	9
251	R:R:R151	R:R:T134	2.59	No	No	0	8	6
252	R:R:F429	R:R:T428	2.59	No	No	0	8	7
253	R:R:V91	R:R:W413	2.45	No	Yes	0	8	8
254	R:R:D108	R:R:R104	2.38	No	No	0	6	3
255	R:R:L40	R:R:Y37	2.34	No	No	0	5	5
256	R:R:P404	R:R:P405	1.95	Yes	No	0	6	3
257	R:R:A77	R:R:C56	1.81	No	No	0	9	7
258	R:R:A436	R:R:A58	1.79	No	No	0	9	9
259	R:R:G380	R:R:L379	1.71	No	No	0	7	8
260	R:R:A420	R:R:V47	1.7	No	No	0	7	5
261	R:R:M138	R:R:P139	1.68	Yes	No	0	6	9
262	R:R:C385	R:R:I384	1.64	No	No	0	9	5
263	R:R:N402	R:R:P404	1.63	No	Yes	0	1	6
264	R:R:S157	R:R:V161	1.62	No	No	0	5	5
265	R:R:A185	R:R:I397	1.62	No	No	0	7	6
266	R:R:A137	R:R:M138	1.61	No	Yes	0	8	6
267	R:R:T85	R:R:V49	1.59	No	No	0	6	7
268	R:R:T165	R:R:V161	1.59	No	No	0	5	5
269	R:R:C399	R:R:L395	1.59	No	No	0	6	7
270	R:R:C443	R:R:L438	1.59	No	No	0	9	5
271	R:R:A371	R:R:L216	1.58	No	No	0	9	8
272	R:R:T39	R:R:T42	1.57	No	No	0	6	4
273	R:R:I212	R:R:V136	1.54	No	No	0	9	8
274	R:R:I195	R:R:V200	1.54	No	No	0	6	8
275	R:R:F172	R:R:G173	1.51	No	No	0	6	7
276	R:R:K149	R:R:T153	1.5	No	No	0	6	5
277	R:R:L363	R:R:S364	1.5	No	No	0	5	6
278	R:R:I210	R:R:I214	1.47	No	No	0	4	5
279	R:R:I183	R:R:L94	1.43	No	No	0	5	7
280	R:R:Q373	R:R:T372	1.42	No	No	0	8	8
281	R:R:K435	R:R:L438	1.41	No	No	0	6	5
282	R:R:L441	R:R:L54	1.38	No	No	0	8	8
283	R:R:L206	R:R:L207	1.38	No	No	0	6	5
284	R:R:N176	R:R:N186	1.36	No	Yes	0	7	7
285	R:R:R150	R:R:V154	1.31	No	No	0	6	3
286	R:R:R219	R:R:V215	1.31	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.71444	9	1	0
2	R:R:I48	4.2325	4	0	8
3	R:R:N52	8.8325	4	0	9
4	R:R:M57	4.7925	4	5	5
5	R:R:L65	8.0325	4	4	9
6	R:R:T68	5.4075	4	3	7
7	R:R:L76	5.695	4	1	9
8	R:R:D80	9.13	4	0	9
9	R:R:W90	11.138	5	2	6
10	R:R:W100	10.0586	7	2	9
11	R:R:M117	5.09	4	0	7
12	R:R:L125	5.0425	4	1	8
13	R:R:D131	6.088	5	3	8
14	R:R:Y133	8.142	5	1	8
15	R:R:M138	4.0725	4	0	6
16	R:R:Y142	7.4425	4	3	8
17	R:R:W160	4.708	5	6	9
18	R:R:L170	8.214	5	1	8
19	R:R:N186	4.405	4	0	7
20	R:R:F189	8.08833	6	1	8
21	R:R:F198	9.255	6	1	9
22	R:R:Y209	9.286	5	1	9
23	R:R:E368	6.255	4	0	9
24	R:R:F382	5.91	4	1	9
25	R:R:W386	7.87	7	1	9
26	R:R:F389	9.392	5	1	8
27	R:R:F390	11.358	5	1	8
28	R:R:H393	9.6825	4	1	8
29	R:R:I403	5.2075	4	8	6
30	R:R:P404	3.01	4	0	6
31	R:R:W413	6.8525	4	0	8
32	R:R:Y416	7.19	4	0	8
33	R:R:N422	6.108	5	1	9
34	R:R:Y426	5.63375	8	1	9
35	R:R:F433	11.384	5	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D114	63.0048	13.39	Yes	No	0	0	8
2	R:R:D114	R:R:Y416	27.7705	8.05	No	Yes	0	8	8
3	R:R:V91	R:R:Y416	25.3564	3.79	No	Yes	0	8	8
4	R:R:V91	R:R:W413	23.6297	2.45	No	Yes	0	8	8
5	R:R:E95	R:R:W413	18.0233	8.72	No	Yes	0	7	8
6	R:R:A38	R:R:E95	16.0807	3.02	No	No	0	7	7
7	R:R:A38	R:R:V96	12.1272	3.39	No	No	0	7	6
8	R:R:V96	R:R:Y36	10.1335	3.79	No	No	0	6	5
9	L:L:?1	R:R:W386	96.1261	4.09	Yes	Yes	1	0	9
10	R:R:N418	R:R:W386	99.591	7.91	No	Yes	0	9	9
11	R:R:N418	R:R:N422	99.0798	8.17	No	Yes	0	9	9
12	R:R:D80	R:R:N422	100	6.73	Yes	Yes	0	9	9
13	R:R:D80	R:R:S419	10.9344	11.78	Yes	No	0	9	9
14	R:R:D80	R:R:N52	91.048	12.12	Yes	Yes	0	9	9
15	R:R:L81	R:R:N52	14.3028	5.49	No	Yes	0	8	9
16	R:R:N52	R:R:P423	16.0636	13.03	Yes	No	0	9	9
17	R:R:G51	R:R:P423	14.3028	4.06	No	No	0	9	9
18	R:R:F50	R:R:G51	12.5305	3.01	No	No	0	5	9
19	R:R:F50	R:R:L54	10.7469	8.53	No	No	0	5	8
20	R:R:A77	R:R:N52	68.4749	4.69	No	Yes	0	9	9
21	R:R:A77	R:R:V55	65.7143	3.39	No	No	0	9	9
22	R:R:T427	R:R:V55	64.317	7.93	No	No	0	8	9
23	R:R:F433	R:R:T427	58.1596	14.27	Yes	No	4	9	8
24	R:R:F433	R:R:N70	40.852	8.46	Yes	No	4	9	9
25	R:R:N70	R:R:T67	40.3011	11.7	No	No	0	9	8
26	R:R:T67	R:R:T69	38.7276	4.71	No	No	0	8	8
27	R:R:D131	R:R:T69	20.1136	4.34	Yes	No	3	8	8
28	R:R:D131	R:R:T68	13.7177	8.67	Yes	Yes	3	8	7
29	R:R:T68	R:R:V152	20.852	3.17	Yes	No	0	7	7
30	R:R:V152	R:R:Y71	17.4041	3.79	No	No	0	7	7
31	R:R:Q66	R:R:Y71	13.9449	10.15	No	No	0	8	7
32	R:R:T69	R:R:Y142	17.0009	6.24	No	Yes	3	8	8
33	R:R:T68	R:R:Y142	13.7972	4.99	Yes	Yes	3	7	8
34	R:R:N422	R:R:Y426	61.4144	4.65	Yes	Yes	1	9	9
35	R:R:L76	R:R:N422	16.6146	6.87	Yes	Yes	1	9	9
36	R:R:L76	R:R:N124	29.662	8.24	Yes	No	0	9	8
37	R:R:D114	R:R:V87	42.5731	7.3	No	No	0	8	8
38	R:R:V83	R:R:V87	20.5396	4.81	No	No	0	8	8
39	R:R:M117	R:R:V83	20.0227	4.56	Yes	No	0	7	8
40	R:R:M117	R:R:W160	19.6819	5.82	Yes	Yes	0	7	9
41	R:R:S75	R:R:W160	20.977	4.94	No	Yes	0	9	9
42	R:R:N124	R:R:S75	22.8174	8.94	No	No	0	8	9
43	R:R:F382	R:R:L125	38.9094	4.87	Yes	Yes	1	9	8
44	R:R:F198	R:R:W386	16.6487	5.01	Yes	Yes	1	9	9
45	R:R:F198	R:R:F382	13.303	6.43	Yes	Yes	1	9	9
46	L:L:?1	R:R:F390	15.5524	9.83	Yes	Yes	1	0	8
47	R:R:F198	R:R:F390	27.8557	20.36	Yes	Yes	1	9	8
48	R:R:L125	R:R:N422	14.6208	4.12	Yes	Yes	1	8	9
49	R:R:L82	R:R:M117	11.9568	5.65	No	Yes	0	7	7
50	R:R:F110	R:R:V87	25.0497	5.24	No	No	0	7	8
51	R:R:F110	R:R:W100	14.3766	7.02	No	Yes	2	7	9
52	L:L:?1	R:R:V115	24.885	13.37	Yes	No	1	0	8
53	R:R:L170	R:R:V115	11.8148	4.47	Yes	No	1	8	8
54	R:R:M116	R:R:M117	15.8535	4.33	No	Yes	0	7	7
55	R:R:F189	R:R:V115	11.3774	3.93	Yes	No	1	8	8
56	L:L:?1	R:R:S193	16.7623	9.43	Yes	No	0	0	9
57	R:R:F189	R:R:S193	11.7353	9.25	Yes	No	0	8	9
58	R:R:I122	R:R:P201	10.9287	3.39	No	No	0	9	9
59	R:R:R132	R:R:Y426	36.092	4.12	No	Yes	1	9	9
60	R:R:R132	R:R:Y209	34.8424	10.29	No	Yes	1	9	9
61	R:R:S129	R:R:Y209	60.0738	16.53	No	Yes	1	9	9
62	R:R:V378	R:R:Y426	36.2567	8.83	No	Yes	0	9	9
63	R:R:V378	R:R:Y209	34.7288	8.83	No	Yes	0	9	9
64	R:R:S129	R:R:V208	56.91	4.85	No	No	1	9	7
65	R:R:V208	R:R:Y133	50.2585	3.79	No	Yes	1	7	8
66	R:R:A137	R:R:Y133	26.998	9.34	No	Yes	0	8	8
67	R:R:I212	R:R:Y133	17.1769	6.04	No	Yes	0	9	8
68	R:R:A137	R:R:M138	23.6183	1.61	No	Yes	0	8	6
69	R:R:M138	R:R:T134	13.411	4.52	Yes	No	0	6	6
70	R:R:F189	R:R:L174	13.3144	4.87	Yes	No	0	8	7
71	L:L:?1	R:R:H393	25.4928	11.53	Yes	Yes	1	0	8
72	R:R:F198	R:R:F202	29.5087	12.86	Yes	No	1	9	7
73	R:R:F202	R:R:I383	49.219	10.05	No	No	0	7	7
74	R:R:I383	R:R:L379	47.1741	7.14	No	No	0	7	8
75	R:R:L206	R:R:L379	43.0503	11.07	No	No	0	6	8
76	R:R:I210	R:R:L206	36.7793	5.71	No	No	0	4	6
77	R:R:I210	R:R:I214	34.6663	1.47	No	No	0	4	5
78	R:R:I214	R:R:Y213	30.3266	3.63	No	No	7	5	7
79	R:R:T372	R:R:Y213	28.242	4.99	No	No	0	8	7
80	R:R:I212	R:R:V136	13.7575	1.54	No	No	0	9	8
81	R:R:V136	R:R:V215	10.3323	3.21	No	No	0	8	7
82	R:R:E368	R:R:T372	24.1295	4.23	Yes	No	0	9	8
83	R:R:E368	R:R:R220	15.5694	12.79	Yes	No	0	9	6
84	R:R:Q365	R:R:R220	11.349	11.68	No	No	0	5	6
85	R:R:I425	R:R:Y426	16.6316	6.04	No	Yes	0	8	9
86	R:R:I377	R:R:I425	11.1218	2.94	No	No	0	8	8
87	L:L:?1	R:R:F389	19.6535	17.48	Yes	Yes	1	0	8
88	R:R:F389	R:R:Y408	39.6365	4.13	Yes	No	1	8	5
89	R:R:N396	R:R:Y408	54.4959	6.98	No	No	0	5	5
90	R:R:I403	R:R:N396	50.9458	7.08	Yes	No	0	6	5
91	R:R:I403	R:R:T392	31.5763	4.56	Yes	No	0	6	5
92	R:R:F411	R:R:T392	27.6683	6.49	No	No	0	5	5
93	R:R:H393	R:R:Y408	18.2505	5.44	Yes	No	1	8	5
94	R:R:I403	R:R:L395	11.9057	4.28	Yes	No	8	6	7
95	R:R:F411	R:R:L407	19.8182	9.74	No	No	0	5	6
96	R:R:L407	R:R:P404	15.8762	4.93	No	Yes	0	6	6
97	R:R:F390	R:R:W386	16.5294	9.02	Yes	Yes	1	8	9
98	R:R:F389	R:R:F390	27.5547	9.65	Yes	Yes	1	8	8
99	R:R:L125	R:R:Y426	18.2789	7.03	Yes	Yes	1	8	9
100	R:R:F202	R:R:F382	21.7381	8.57	No	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D114	13.39	1	Yes	No	0	8	0	1
L:L:?1	R:R:V115	13.37	1	Yes	No	0	8	0	1
L:L:?1	R:R:C118	4.27	1	Yes	No	0	8	0	1
L:L:?1	R:R:S193	9.43	1	Yes	No	0	9	0	1
L:L:?1	R:R:S197	4.04	1	Yes	No	0	8	0	1
L:L:?1	R:R:W386	4.09	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F389	17.48	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F390	9.83	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:H393	11.53	1	Yes	Yes	0	8	0	1
R:R:D114	R:R:V87	7.3	0	No	No	8	8	1	2
R:R:D114	R:R:Y416	8.05	0	No	Yes	8	8	1	2
R:R:L170	R:R:V115	4.47	1	Yes	No	8	8	2	1
R:R:F189	R:R:V115	3.93	1	Yes	No	8	8	2	1
R:R:C118	R:R:W386	6.53	1	No	Yes	8	9	1	1
R:R:S197	R:R:T119	6.4	0	No	No	8	8	1	2
R:R:I122	R:R:W386	14.09	0	No	Yes	9	9	2	1
R:R:F189	R:R:L170	19.49	1	Yes	Yes	8	8	2	2
R:R:F189	R:R:S193	9.25	1	Yes	No	8	9	2	1
R:R:H393	R:R:V190	13.84	1	Yes	No	8	7	1	2
R:R:F390	R:R:S194	7.93	1	Yes	No	8	8	1	2
R:R:F198	R:R:W386	5.01	1	Yes	Yes	9	9	2	1
R:R:F198	R:R:F390	20.36	1	Yes	Yes	9	8	2	1
R:R:F390	R:R:W386	9.02	1	Yes	Yes	8	9	1	1
R:R:G415	R:R:W386	8.44	0	No	Yes	8	9	2	1
R:R:N418	R:R:W386	7.91	0	No	Yes	9	9	2	1
R:R:F389	R:R:F390	9.65	1	Yes	Yes	8	8	1	1
R:R:F389	R:R:H393	7.92	1	Yes	Yes	8	8	1	1
R:R:F389	R:R:Y408	4.13	1	Yes	No	8	5	1	2
R:R:F389	R:R:T412	7.78	1	Yes	No	8	8	1	2
R:R:H393	R:R:Y408	5.44	1	Yes	No	8	5	1	2
R:R:T412	R:R:Y416	3.75	0	No	Yes	8	8	2	2
R:R:I166	R:R:S193	3.1	0	No	No	8	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8U02_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	256
Number of Links	286
Number of Hubs	35
Number of Links mediated by Hubs	143
Number of Communities	8
Number of Nodes involved in Communities	57
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	50239
Length Of Smallest Path	3
Average Path Length	13.7771
Length of Longest Path	34
Minimum Path Strength	1.5
Average Path Strength	7.12414
Maximum Path Strength	18.485
Minimum Path Correlation	0.7
Average Path Correlation	0.921235
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	47.3117
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.2929
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • ion binding • binding • catecholamine binding • dopamine binding • small molecule binding • protein binding • G-protein alpha-subunit binding • monoatomic cation transmembrane transporter activity • channel regulator activity • ion channel regulator activity • monoatomic ion channel activity • potassium ion transmembrane transporter activity • potassium channel activity • potassium channel regulator activity • monoatomic cation channel activity • passive transmembrane transporter activity • inorganic molecular entity transmembrane transporter activity • channel activity • molecular function regulator activity • inorganic cation transmembrane transporter activity • monoatomic ion transmembrane transporter activity • transporter activity • transporter regulator activity • metal ion transmembrane transporter activity • transmembrane transporter activity • protein-containing complex binding • heterotrimeric G-protein binding • heterocyclic compound binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • signaling receptor activity • identical protein binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • ionotropic glutamate receptor binding • signaling receptor binding • glutamate receptor binding • response to stimulus • response to chemical • response to xenobiotic stimulus • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • negative regulation of protein transport • protein localization • regulation of localization • establishment of protein localization • cellular localization • nitrogen compound transport • regulation of cellular process • regulation of protein localization • negative regulation of biological process • negative regulation of transport • protein localization to extracellular region • regulation of secretion by cell • secretion by cell • negative regulation of secretion • cellular macromolecule localization • negative regulation of cellular process • negative regulation of secretion by cell • negative regulation of protein localization • regulation of biological process • regulation of transport • biological regulation • regulation of establishment of protein localization • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • regulation of cellular localization • cellular process • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • catabolic process • autophagy • metabolic process • process utilizing autophagic mechanism • cellular response to stimulus • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • response to retinoic acid • cellular response to chemical stimulus • cellular response to retinoic acid • cellular response to lipid • response to toxic substance • multicellular organismal process • cellular developmental process • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • multicellular organism development • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • cell differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • anatomical structure development • cell migration • cell motility • GABAergic neuron differentiation • system development • developmental process • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • animal organ development • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • response to metal ion • response to iron ion • regulation of biosynthetic process • rhythmic process • circadian regulation of gene expression • circadian rhythm • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of metabolic process • regulation of cellular response to hypoxia • cellular response to oxygen levels • cellular response to hypoxia • regulation of cellular response to stress • cellular response to decreased oxygen levels • cellular response to stress • regulation of response to stress • response to stress • response to decreased oxygen levels • negative regulation of response to stimulus • negative regulation of cellular response to hypoxia • regulation of response to stimulus • response to hypoxia • response to oxygen levels • response to abiotic stimulus • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • biogenic amine metabolic process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of glial cell-derived neurotrophic factor production • positive regulation of gene expression • glial cell-derived neurotrophic factor production • positive regulation of multicellular organismal process • positive regulation of cytokine production • positive regulation of glial cell-derived neurotrophic factor production • regulation of potassium ion transport • regulation of monoatomic ion transport • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • response to alcohol • cellular response to alcohol • cellular response to ethanol • response to ethanol • negative regulation of locomotion • regulation of cell motility • regulation of locomotion • regulation of cell migration • negative regulation of cell motility • negative regulation of cell migration • locomotion • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • negative regulation of signaling • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of cell communication • synaptic signaling • trans-synaptic signaling • regulation of signaling • cell-cell signaling • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • negative regulation of synaptic transmission, glutamatergic • response to morphine • response to isoquinoline alkaloid • response to nitrogen compound • response to alkaloid • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • monoamine transport • positive regulation of dopamine uptake involved in synaptic transmission • import into cell • regulation of catecholamine uptake involved in synaptic transmission • organic hydroxy compound transport • dopamine transport • catecholamine uptake • positive regulation of amine transport • dopamine uptake involved in synaptic transmission • catecholamine transport • establishment of localization in cell • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • positive regulation of neurotransmitter transport • catecholamine uptake involved in synaptic transmission • regulation of neurotransmitter transport • neurotransmitter transport • amine transport • positive regulation of catecholamine uptake involved in synaptic transmission • positive regulation of transport • positive regulation of neurotransmitter uptake • neurotransmitter uptake • regulation of amine transport • synaptic transmission, dopaminergic • dopamine uptake • adult walking behavior • adult locomotory behavior • behavior • adult behavior • locomotory behavior • walking behavior • acid secretion • response to auditory stimulus • auditory behavior • response to mechanical stimulus • response to external stimulus • mechanosensory behavior • negative adaptation of signaling pathway • receptor internalization • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • vesicle-mediated transport • regulation of G protein-coupled receptor signaling pathway • G protein-coupled receptor internalization • negative regulation of signal transduction • adaptation of signaling pathway • receptor-mediated endocytosis • endocytosis • phospholipase C-activating dopamine receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • system process • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • neuron-neuron synaptic transmission • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • long-term synaptic potentiation • positive regulation of long-term synaptic potentiation • regulation of synaptic plasticity • positive regulation of synaptic transmission • regulation of long-term synaptic potentiation • morphogenesis of a branching structure • branching morphogenesis of a nerve • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • regulation of catecholamine secretion • signal release • dopamine secretion • catecholamine secretion • regulation of dopamine secretion • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • negative regulation of hormone secretion • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • negative regulation of peptide secretion • peptide secretion • amide transport • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • cell surface receptor signaling pathway • excitatory postsynaptic potential • regulation of membrane potential • cell population proliferation • epithelial cell proliferation • renal sodium excretion • inorganic ion homeostasis • regulation of renal system process • homeostatic process • regulation of system process • positive regulation of secretion • monoatomic ion homeostasis • monoatomic cation homeostasis • positive regulation of renal sodium excretion • excretion • sodium ion homeostasis • renal tubular secretion • regulation of renal sodium excretion • chemical homeostasis • regulation of excretion • intracellular calcium ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • negative regulation of sequestering of calcium ion • calcium ion transport • maintenance of location in cell • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • intracellular chemical homeostasis • regulation of sequestering of calcium ion • intracellular monoatomic ion homeostasis • calcium ion transmembrane import into cytosol • sequestering of calcium ion • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • cellular homeostasis • calcium ion transmembrane transport • response to inactivity • multicellular organismal-level homeostasis • temperature homeostasis • learning • learning or memory • cognition • associative learning • response to amine • response to amphetamine • Wnt signaling pathway • negative regulation of neuron migration • regulation of neuron migration • regulation of sodium ion transport • sodium ion transport • grooming behavior • response to estradiol • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • neuroblast proliferation • neural precursor cell proliferation • heart process • regulation of heart contraction • regulation of blood circulation • heart contraction • regulation of heart rate • response to wounding • response to axon injury • endocrine system development • pituitary gland development • gland development • diencephalon development • adenohypophysis development • positive regulation of G protein-coupled receptor signaling pathway • regulation of cellular component organization • regulation of synapse structural plasticity • regulation of synapse organization • cell junction organization • regulation of synapse structure or activity • synapse organization • presynaptic modulation of chemical synaptic transmission • response to light stimulus • response to radiation • negative regulation of amine transport • negative regulation of dopamine secretion • negative regulation of catecholamine secretion • drinking behavior • feeding behavior • response to histamine • startle response • regulation of response to external stimulus • neuromuscular process • prepulse inhibition • negative regulation of response to external stimulus • regulation of neuronal synaptic plasticity • regulation of long-term neuronal synaptic plasticity • regulation of dopamine receptor signaling pathway • negative regulation of dopamine receptor signaling pathway • postsynaptic modulation of chemical synaptic transmission • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of intracellular signal transduction • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • pigmentation • striatum development • subpallium development • regulation of systemic arterial blood pressure • nervous system process involved in regulation of systemic arterial blood pressure • negative regulation of cell population proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • negative regulation of epithelial cell proliferation • cellular component biogenesis • cellular component assembly • cell junction assembly • synapse assembly • negative regulation of behavior • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • negative regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle • negative regulation of circadian rhythm • regulation of circadian rhythm • regulation of behavior • circadian behavior • sleep • negative regulation of multicellular organismal process • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • locomotion involved in locomotory behavior • regulation of locomotion involved in locomotory behavior • orbitofrontal cortex development • limbic system development • behavioral response to cocaine • response to cocaine • regulation of dephosphorylation • negative regulation of metabolic process • dephosphorylation • negative regulation of phosphate metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of phosphorus metabolic process • negative regulation of dephosphorylation • regulation of phosphorus metabolic process • phosphorus metabolic process • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • sensory organ development • eye development • visual system development • anatomical structure regression • hyaloid vascular plexus regression • camera-type eye development • sensory system development • positive regulation of cellular component organization • regulation of receptor internalization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • negative regulation of response to biotic stimulus • response to biotic stimulus • innate immune response • regulation of immune system process • response to external biotic stimulus • immune response • response to other organism • defense response • regulation of innate immune response • negative regulation of immune response • defense response to symbiont • negative regulation of immune system process • immune system process • defense response to other organism • negative regulation of defense response • regulation of immune response • negative regulation of innate immune response • adenylate cyclase-inhibiting dopamine receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • visual learning • visual behavior • behavioral response to ethanol • long-term memory • memory • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of developmental growth • response to nicotine • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of peptide secretion • growth hormone secretion • regulation of growth hormone secretion • positive regulation of peptide hormone secretion • positive regulation of growth hormone secretion • positive regulation of nervous system development • positive regulation of cell population proliferation • regulation of neuroblast proliferation • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • regulation of multicellular organismal development • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • membrane-bounded organelle • Golgi membrane • intracellular anatomical structure • Golgi apparatus • membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • bounding membrane of organelle
Gene Ontology	Cellular Component	• somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • membrane-bounded organelle • Golgi membrane • intracellular anatomical structure • Golgi apparatus • membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • bounding membrane of organelle • organelle • cytoplasm • organelle membrane • neuron spine • synapse • neuron projection • dendritic spine • plasma membrane bounded cell projection • cell projection • postsynapse • cell junction • dendrite • dendritic tree • acrosomal vesicle • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • cell periphery • plasma membrane • non-motile cilium • cilium • GABA-ergic synapse • ciliary membrane • plasma membrane region • cell projection membrane • lateral plasma membrane • postsynaptic membrane • synaptic membrane • protein-containing complex • plasma membrane protein complex • plasma membrane signaling receptor complex • G protein-coupled receptor complex • membrane protein complex • receptor complex • 9+2 motile cilium • sperm flagellum • motile cilium • presynapse • presynaptic membrane • dopaminergic synapse • endocytic vesicle • glutamatergic synapse • transport vesicle membrane • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • exocytic vesicle • axon • axon terminus • distal axon • neuron projection terminus • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	LDP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	LDP
Name	Dopamine
Synonyms	Dopaminum
Identifier
Formula	C8 H11 N O2
Molecular Weight	153.178
SMILES
PubChem	681
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	0
Total Bonds	22
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P14416
Sequence	>8U02_nogp_Chain_R Y Y A T L L T L L I A V I V F G N V L V C M A V S R E K A L Q T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G E W K F S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M P M L Y N T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G L N N A D Q N E C I I A N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N R K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C D C N I P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F R K A F L K I L H C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8U02	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-	Go/β1/γ2	3.28	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8U02 (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-		3.28	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8TZQ	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-	Go/β1/γ2	3.2	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8TZQ (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-		3.2	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8JD2	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	2.8	2023-06-21	10.1038/s41422-023-00830-2
	8IRS	A	Amine	Dopamine	D₂	Homo sapiens	Rotigotine	-	Gi1/β1/γ2	3	2023-06-07	10.1038/s41422-023-00808-0
	8IRS (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Rotigotine	-		3	2023-06-07	10.1038/s41422-023-00808-0
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	10.1038/s41467-022-28417-2
	7M8W	A	Lipid	Prostanoid	DP₂	Homo sapiens	15r-Methyl-Prostaglandin D2	Na	-	2.61	2021-08-25	10.1073/pnas.2102813118
	7JVR	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-	Gi1/β1/γ2	2.8	2021-02-24	10.1016/j.cell.2021.01.027
	7JVR (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-		2.8	2021-02-24	10.1016/j.cell.2021.01.027
	7DFP	A	Amine	Dopamine	D₂	Homo sapiens	Spiperone	-	-	3.1	2020-12-30	10.1038/s41467-020-20221-0
	6VMS	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-	Gi1/β1/γ2	3.8	2020-06-17	10.1038/s41586-020-2379-5
	6VMS (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-		3.8	2020-06-17	10.1038/s41586-020-2379-5
	6LUQ	A	Amine	Dopamine	D₂	Homo sapiens	Haloperidol	-	-	3.1	2020-03-04	10.1038/s41467-020-14884-y
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	10.1016/j.molcel.2018.08.009
	6D26	A	Lipid	Prostanoid	DP₂	Homo sapiens	Fevipiprant	-	-	2.8	2018-10-03	10.1016/j.molcel.2018.08.009
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	10.1038/nature25758

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