psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L41	R:R:V92	5.96	No	No	2	7	8
2	R:R:L41	R:R:W413	14.81	No	Yes	2	7	8
3	R:R:I48	R:R:L44	5.71	Yes	No	0	8	7
4	R:R:I45	R:R:M88	4.37	No	No	0	8	9
5	R:R:I48	R:R:M88	4.37	Yes	No	0	8	9
6	R:R:I48	R:R:S419	4.64	Yes	No	0	8	9
7	R:R:L81	R:R:V49	4.47	No	No	0	8	7
8	R:R:F50	R:R:G51	4.52	No	No	0	5	9
9	R:R:F50	R:R:L54	7.31	No	Yes	0	5	8
10	R:R:A77	R:R:N52	4.69	No	Yes	0	9	9
11	R:R:D80	R:R:N52	12.12	Yes	Yes	0	9	9
12	R:R:L81	R:R:N52	4.12	No	Yes	0	8	9
13	R:R:N52	R:R:P423	13.03	Yes	No	0	9	9
14	R:R:F437	R:R:L54	7.31	No	Yes	0	9	8
15	R:R:L441	R:R:L54	4.15	No	Yes	0	8	8
16	R:R:I440	R:R:M57	4.37	No	No	0	8	5
17	R:R:V59	R:R:V74	4.81	No	No	0	8	7
18	R:R:I440	R:R:R61	6.26	No	No	0	8	7
19	R:R:E62	R:R:L65	5.3	No	No	0	8	9
20	R:R:E62	R:R:K439	6.75	No	No	0	8	7
21	R:R:A64	R:R:E432	4.53	No	No	0	7	7
22	R:R:F433	R:R:L65	12.18	Yes	No	0	9	9
23	R:R:Q66	R:R:Y71	7.89	No	No	0	8	7
24	R:R:N70	R:R:T67	5.85	Yes	No	0	9	8
25	R:R:T67	R:R:Y142	6.24	No	Yes	0	8	8
26	R:R:D131	R:R:T68	8.67	Yes	Yes	3	8	7
27	R:R:T68	R:R:Y142	11.24	Yes	Yes	3	7	8
28	R:R:S148	R:R:T68	4.8	No	Yes	0	6	7
29	R:R:N70	R:R:T69	5.85	Yes	No	0	9	8
30	R:R:D131	R:R:T69	5.78	Yes	No	3	8	8
31	R:R:T69	R:R:Y142	6.24	No	Yes	3	8	8
32	R:R:F433	R:R:N70	8.46	Yes	Yes	0	9	9
33	R:R:I73	R:R:Y426	7.25	No	Yes	0	8	9
34	R:R:N124	R:R:S75	8.94	No	No	0	8	9
35	R:R:I156	R:R:S75	10.84	No	No	0	9	9
36	R:R:S75	R:R:W160	6.18	No	Yes	0	9	9
37	R:R:L76	R:R:N124	8.24	Yes	No	0	9	8
38	R:R:L125	R:R:L76	5.54	Yes	Yes	1	8	9
39	R:R:I128	R:R:L76	4.28	No	Yes	1	9	9
40	R:R:L76	R:R:N422	12.36	Yes	Yes	1	9	9
41	R:R:D80	R:R:S121	4.42	Yes	No	0	9	9
42	R:R:D80	R:R:S419	11.78	Yes	No	0	9	9
43	R:R:D80	R:R:N422	10.77	Yes	Yes	0	9	9
44	R:R:L82	R:R:L86	8.3	No	No	0	7	5
45	R:R:L82	R:R:M117	9.9	No	No	0	7	7
46	R:R:S419	R:R:V83	6.46	No	No	0	9	8
47	R:R:L113	R:R:L86	4.15	No	No	0	6	5
48	R:R:D114	R:R:V87	5.84	No	No	0	8	8
49	R:R:M88	R:R:Y416	10.78	No	Yes	0	9	8
50	R:R:H106	R:R:W90	8.46	No	No	0	6	6
51	R:R:F110	R:R:W90	9.02	Yes	No	0	7	6
52	R:R:V91	R:R:W413	4.9	No	Yes	0	8	8
53	R:R:V91	R:R:Y416	8.83	No	Yes	0	8	8
54	R:R:V92	R:R:W413	4.9	No	Yes	2	8	8
55	R:R:V97	R:R:Y93	10.09	No	No	0	5	6
56	R:R:E95	R:R:S409	10.06	No	No	2	7	6
57	R:R:E95	R:R:W413	7.63	No	Yes	2	7	8
58	R:R:E99	R:R:K101	5.4	No	No	0	4	4
59	R:R:F102	R:R:W100	10.02	No	Yes	4	7	9
60	R:R:H106	R:R:W100	5.29	No	Yes	4	6	9
61	R:R:F110	R:R:W100	9.02	Yes	Yes	0	7	9
62	R:R:C182	R:R:W100	7.84	No	Yes	0	9	9
63	R:R:F102	R:R:K101	6.2	No	No	0	7	4
64	R:R:F102	R:R:H106	12.44	No	No	4	7	6
65	R:R:C107	R:R:C182	7.28	No	No	0	9	9
66	R:R:D108	R:R:G173	5.03	No	No	0	6	7
67	R:R:F110	R:R:V111	5.24	Yes	No	0	7	6
68	R:R:L170	R:R:V111	4.47	Yes	No	0	8	6
69	R:R:L170	R:R:T112	4.42	Yes	No	0	8	8
70	R:R:L171	R:R:T112	10.32	No	No	0	7	8
71	R:R:D114	R:R:Y416	6.9	No	Yes	1	8	8
72	L:L:?1	R:R:D114	16.76	Yes	No	1	0	8
73	R:R:S167	R:R:V115	6.46	No	No	0	9	8
74	L:L:?1	R:R:V115	12.59	Yes	No	0	0	8
75	R:R:M116	R:R:M117	7.22	Yes	No	0	7	7
76	R:R:M116	R:R:S163	6.13	Yes	No	0	7	8
77	R:R:F164	R:R:M116	4.98	No	Yes	0	6	7
78	R:R:M116	R:R:S167	4.6	Yes	No	0	7	9
79	R:R:C118	R:R:W386	5.22	No	Yes	0	8	9
80	L:L:?1	R:R:C118	4.13	Yes	No	0	0	8
81	R:R:S197	R:R:T119	9.59	No	No	0	8	8
82	R:R:A120	R:R:W160	6.48	No	Yes	0	8	9
83	R:R:I122	R:R:W386	12.92	No	Yes	0	9	9
84	R:R:L123	R:R:V159	4.47	No	No	0	8	9
85	R:R:L123	R:R:L162	5.54	No	No	0	8	7
86	R:R:N124	R:R:V159	5.91	No	No	0	8	9
87	R:R:F382	R:R:L125	7.31	Yes	Yes	1	9	8
88	R:R:L125	R:R:N422	6.87	Yes	Yes	1	8	9
89	R:R:L125	R:R:Y426	5.86	Yes	Yes	1	8	9
90	R:R:I128	R:R:R132	5.01	No	No	1	9	9
91	R:R:I128	R:R:Y426	6.04	No	Yes	1	9	9
92	R:R:S129	R:R:T205	9.59	No	No	0	9	9
93	R:R:S129	R:R:Y209	15.26	No	Yes	0	9	9
94	R:R:D131	R:R:Y142	8.05	Yes	Yes	3	8	8
95	R:R:D131	R:R:R151	8.34	Yes	No	0	8	8
96	R:R:R132	R:R:Y209	9.26	No	Yes	1	9	9
97	R:R:R132	R:R:Y426	7.2	No	Yes	1	9	9
98	R:R:A137	R:R:Y133	9.34	No	No	0	8	8
99	R:R:K211	R:R:Y133	9.55	No	No	0	7	8
100	R:R:R151	R:R:T134	14.23	No	No	0	8	6
101	R:R:A135	R:R:Y142	6.67	No	Yes	0	8	8
102	R:R:V136	R:R:V215	4.81	No	No	0	8	7
103	R:R:L141	R:R:M138	7.07	No	No	0	6	6
104	R:R:I166	R:R:L162	4.28	No	No	0	8	7
105	R:R:C168	R:R:F164	5.59	No	No	0	6	6
106	R:R:I166	R:R:V196	4.61	No	No	0	8	6
107	R:R:I166	R:R:S197	6.19	No	No	0	8	8
108	R:R:C168	R:R:F172	6.98	No	No	0	6	6
109	R:R:F189	R:R:P169	7.22	Yes	No	0	8	8
110	R:R:L170	R:R:N175	4.12	Yes	Yes	5	8	7
111	R:R:I184	R:R:L170	4.28	No	Yes	5	7	8
112	R:R:F189	R:R:L170	6.09	Yes	Yes	0	8	8
113	R:R:A177	R:R:N175	4.69	No	Yes	0	4	7
114	R:R:I184	R:R:N175	11.33	No	Yes	5	7	7
115	R:R:N175	R:R:N186	8.17	Yes	No	0	7	7
116	R:R:E181	R:R:I183	5.47	No	No	0	4	5
117	L:L:?1	R:R:I183	9.28	Yes	No	0	0	5
118	R:R:F189	R:R:N186	10.87	Yes	No	0	8	7
119	R:R:I397	R:R:P187	5.08	No	No	0	6	4
120	R:R:F189	R:R:S193	6.61	Yes	No	0	8	9
121	R:R:H393	R:R:V190	4.15	Yes	No	0	8	7
122	R:R:I397	R:R:V190	4.61	No	No	0	6	7
123	L:L:?1	R:R:S193	7.81	Yes	No	0	0	9
124	R:R:F390	R:R:S194	6.61	Yes	No	0	8	8
125	R:R:I394	R:R:S194	6.19	No	No	0	7	8
126	R:R:F198	R:R:Y199	5.16	Yes	No	0	9	7
127	R:R:F198	R:R:F202	11.79	Yes	No	1	9	7
128	R:R:F198	R:R:F382	5.36	Yes	Yes	1	9	9
129	R:R:F198	R:R:W386	5.01	Yes	Yes	1	9	9
130	R:R:F198	R:R:F390	25.72	Yes	Yes	1	9	8
131	R:R:I391	R:R:Y199	4.84	No	No	0	7	7
132	R:R:I394	R:R:Y199	8.46	No	No	0	7	7
133	R:R:F202	R:R:F382	10.72	No	Yes	1	7	9
134	R:R:F382	R:R:T205	6.49	Yes	No	0	9	9
135	R:R:I210	R:R:L206	4.28	No	No	0	4	6
136	R:R:L206	R:R:L379	4.15	No	No	0	6	8
137	R:R:L375	R:R:Y209	4.69	No	Yes	0	8	9
138	R:R:V378	R:R:Y209	6.31	No	Yes	1	9	9
139	R:R:L379	R:R:Y209	7.03	No	Yes	0	8	9
140	R:R:Y209	R:R:Y426	4.96	Yes	Yes	1	9	9
141	R:R:I212	R:R:L375	5.71	No	No	0	9	8
142	R:R:R217	R:R:Y213	14.4	No	No	0	6	7
143	R:R:T372	R:R:Y213	7.49	No	No	0	8	7
144	R:R:E368	R:R:R219	10.47	No	No	0	9	8
145	R:R:Q366	R:R:Q373	5.12	No	No	0	6	8
146	R:R:F429	R:R:M374	9.95	No	No	0	8	9
147	R:R:I377	R:R:I425	4.42	No	No	0	8	8
148	R:R:V378	R:R:Y426	7.57	No	Yes	1	9	9
149	R:R:V381	R:R:V421	6.41	No	No	0	7	7
150	R:R:C385	R:R:N418	11.02	No	Yes	0	9	9
151	R:R:F389	R:R:W386	5.01	Yes	Yes	1	8	9
152	R:R:F390	R:R:W386	12.03	Yes	Yes	1	8	9
153	R:R:G415	R:R:W386	8.44	No	Yes	0	8	9
154	R:R:N418	R:R:W386	10.17	Yes	Yes	0	9	9
155	R:R:I391	R:R:L387	4.28	No	No	0	7	7
156	R:R:F411	R:R:P388	10.11	No	No	0	5	9
157	R:R:F389	R:R:F390	9.65	Yes	Yes	1	8	8
158	R:R:F389	R:R:H393	15.84	Yes	Yes	1	8	8
159	R:R:F389	R:R:T412	6.49	Yes	No	1	8	8
160	L:L:?1	R:R:F389	16.62	Yes	Yes	1	0	8
161	L:L:?1	R:R:F390	7.92	Yes	Yes	1	0	8
162	R:R:F411	R:R:T392	7.78	No	No	0	5	5
163	R:R:H393	R:R:Y408	6.53	Yes	No	1	8	5
164	L:L:?1	R:R:H393	5.01	Yes	Yes	1	0	8
165	R:R:H398	R:R:I394	6.63	No	No	0	6	7
166	R:R:I403	R:R:N396	9.91	No	No	1	6	5
167	R:R:N396	R:R:Y408	8.14	No	No	1	5	5
168	R:R:C399	R:R:C401	7.28	No	No	0	6	7
169	R:R:I403	R:R:P404	5.08	No	Yes	0	6	6
170	R:R:I403	R:R:Y408	4.84	No	No	1	6	5
171	R:R:L407	R:R:P404	8.21	No	Yes	0	6	6
172	R:R:F411	R:R:L407	8.53	No	No	0	5	6
173	R:R:S409	R:R:W413	7.41	No	Yes	2	6	8
174	L:L:?1	R:R:T412	9.58	Yes	No	1	0	8
175	L:L:?1	R:R:Y416	12.95	Yes	Yes	1	0	8
176	R:R:N418	R:R:N422	9.54	Yes	Yes	0	9	9
177	R:R:F433	R:R:T427	16.86	Yes	Yes	0	9	8
178	R:R:F437	R:R:T427	10.38	No	Yes	0	9	8
179	R:R:F433	R:R:N430	9.67	Yes	No	0	9	9
180	R:R:D131	R:R:L72	4.07	Yes	No	0	8	8
181	R:R:K370	R:R:Q366	4.07	No	No	0	9	6
182	R:R:G51	R:R:P423	4.06	No	No	0	9	9
183	R:R:E432	R:R:L65	3.98	No	No	0	7	9
184	R:R:Y34	R:R:Y37	3.97	No	No	0	6	5
185	R:R:A79	R:R:W160	3.89	No	Yes	0	8	9
186	R:R:C126	R:R:P201	3.77	No	No	0	7	9
187	R:R:F429	R:R:I377	3.77	No	No	0	8	8
188	R:R:V78	R:R:W160	3.68	No	Yes	0	7	9
189	R:R:F172	R:R:L174	3.65	No	No	0	6	7
190	R:R:I212	R:R:Y133	3.63	No	No	0	9	8
191	R:R:D108	R:R:R104	3.57	No	No	0	6	3
192	R:R:P201	R:R:V200	3.53	No	No	0	9	8
193	R:R:Q179	R:R:R104	3.5	No	No	0	1	3
194	R:R:E368	R:R:R220	3.49	No	No	0	9	6
195	R:R:C126	R:R:V204	3.42	No	No	0	7	8
196	R:R:A38	R:R:V96	3.39	No	No	0	7	6
197	R:R:I45	R:R:P89	3.39	No	No	0	8	9
198	R:R:I122	R:R:P201	3.39	No	No	0	9	9
199	R:R:L414	R:R:P388	3.28	No	No	0	8	9
200	R:R:A84	R:R:I48	3.25	No	Yes	0	8	8
201	R:R:S147	R:R:T144	3.2	No	No	0	8	7
202	R:R:T427	R:R:V55	3.17	Yes	No	0	8	9
203	R:R:T68	R:R:V152	3.17	Yes	No	0	7	7
204	R:R:C399	R:R:L395	3.17	No	No	0	6	7
205	R:R:T427	R:R:T428	3.14	Yes	No	0	8	7
206	R:R:I130	R:R:V204	3.07	No	No	0	7	8
207	R:R:I158	R:R:V154	3.07	No	No	0	4	3
208	R:R:I195	R:R:V191	3.07	No	No	0	6	7
209	R:R:I397	R:R:V191	3.07	No	No	0	6	7
210	R:R:I425	R:R:V421	3.07	No	No	0	8	7
211	R:R:M57	R:R:V53	3.04	No	No	0	5	6
212	R:R:K101	R:R:V97	3.04	No	No	0	4	5
213	R:R:I424	R:R:T428	3.04	No	No	0	7	7
214	R:R:L44	R:R:V417	2.98	No	No	0	7	6
215	R:R:L216	R:R:V136	2.98	Yes	No	0	8	8
216	R:R:N70	R:R:V59	2.96	Yes	No	0	9	8
217	R:R:N418	R:R:V381	2.96	Yes	No	0	9	7
218	R:R:L86	R:R:T85	2.95	No	No	0	5	6
219	R:R:N35	R:R:T39	2.92	No	No	0	7	6
220	R:R:I440	R:R:L54	2.85	No	Yes	0	8	8
221	R:R:I212	R:R:L216	2.85	No	Yes	0	9	8
222	R:R:I383	R:R:L387	2.85	No	No	0	7	7
223	R:R:K211	R:R:L207	2.82	No	No	0	7	5
224	R:R:A58	R:R:F433	2.77	No	Yes	0	9	9
225	R:R:A58	R:R:F437	2.77	No	No	0	9	9
226	R:R:K63	R:R:Q66	2.71	No	No	0	8	8
227	R:R:K369	R:R:Q366	2.71	No	No	0	7	6
228	R:R:V152	R:R:Y71	2.52	No	No	0	7	7
229	R:R:F202	R:R:I203	2.51	No	No	0	7	4
230	R:R:I214	R:R:R218	2.51	No	No	0	5	6
231	R:R:P404	R:R:P405	1.95	Yes	No	0	6	3
232	R:R:A77	R:R:C56	1.81	No	No	0	9	7
233	R:R:A436	R:R:A58	1.79	No	No	0	9	9
234	R:R:A177	R:R:A185	1.79	No	No	0	4	7
235	R:R:P404	R:R:V406	1.77	Yes	No	0	6	4
236	R:R:A420	R:R:V47	1.7	No	No	0	7	5
237	R:R:A127	R:R:V159	1.7	No	No	0	7	9
238	R:R:M138	R:R:P139	1.68	No	No	0	6	9
239	R:R:E99	R:R:G98	1.64	No	No	0	4	5
240	R:R:A420	R:R:I48	1.62	No	Yes	0	7	8
241	R:R:S129	R:R:V208	1.62	No	No	0	9	7
242	R:R:A137	R:R:M138	1.61	No	No	0	8	6
243	R:R:V92	R:R:V96	1.6	No	No	0	8	6
244	R:R:V96	R:R:V97	1.6	No	No	0	6	5
245	R:R:T165	R:R:V161	1.59	No	No	0	5	5
246	R:R:A371	R:R:L216	1.58	No	Yes	0	9	8
247	R:R:L43	R:R:V47	1.49	No	No	0	6	5
248	R:R:I105	R:R:I109	1.47	No	No	0	4	6
249	R:R:I210	R:R:I214	1.47	No	No	0	4	5
250	R:R:I431	R:R:K435	1.45	No	No	0	5	6
251	R:R:Q179	R:R:S103	1.44	No	No	0	1	8
252	R:R:I109	R:R:L113	1.43	No	No	0	6	6
253	R:R:I109	R:R:L171	1.43	No	No	0	6	7
254	R:R:L72	R:R:M155	1.41	No	No	0	8	8
255	R:R:D108	R:R:I105	1.4	No	No	0	6	4
256	R:R:I377	R:R:Q373	1.37	No	No	0	8	8
257	R:R:N176	R:R:N186	1.36	No	No	0	7	7
258	R:R:D178	R:R:N180	1.35	No	No	0	3	3
259	R:R:E432	R:R:K435	1.35	No	No	0	7	6
260	R:R:A188	R:R:Y192	1.33	No	No	0	5	7
261	R:R:R150	R:R:V154	1.31	No	No	0	6	3
262	R:R:S147	R:R:Y146	1.27	No	No	0	8	8
263	R:R:V191	R:R:Y192	1.26	No	No	0	7	7
264	R:R:F110	R:R:L94	1.22	Yes	No	0	7	7
265	R:R:L216	R:R:R219	1.21	Yes	No	0	8	8
266	R:R:L375	R:R:Y213	1.17	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I48	3.918	5	0	8
2	R:R:N52	8.49	4	0	9
3	R:R:L54	5.405	4	0	8
4	R:R:T68	6.97	4	3	7
5	R:R:N70	5.78	4	0	9
6	R:R:L76	7.605	4	1	9
7	R:R:D80	9.7725	4	0	9
8	R:R:W100	8.0425	4	4	9
9	R:R:F110	6.125	4	0	7
10	R:R:M116	5.7325	4	0	7
11	R:R:L125	6.395	4	1	8
12	R:R:D131	6.982	5	3	8
13	R:R:Y142	7.688	5	3	8
14	R:R:W160	5.0575	4	0	9
15	R:R:L170	4.676	5	5	8
16	R:R:N175	7.0775	4	5	7
17	R:R:F189	7.6975	4	0	8
18	R:R:F198	10.608	5	1	9
19	R:R:Y209	7.91833	6	1	9
20	R:R:L216	2.155	4	0	8
21	R:R:F382	7.47	4	1	9
22	R:R:W386	8.4	7	1	9
23	R:R:F389	10.722	5	1	8
24	R:R:F390	12.386	5	1	8
25	R:R:H393	7.8825	4	1	8
26	R:R:P404	4.2525	4	0	6
27	R:R:W413	7.93	5	2	8
28	R:R:Y416	9.865	4	1	8
29	R:R:N418	8.4225	4	0	9
30	R:R:N422	9.885	4	1	9
31	R:R:Y426	6.48	6	1	9
32	R:R:T427	8.3875	4	0	8
33	R:R:F433	9.988	5	0	9
34	L:L:?1	10.265	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I48	R:R:M88	25.0645	4.37	Yes	No	0	8	9
2	R:R:M88	R:R:Y416	24.9577	10.78	No	Yes	0	9	8
3	R:R:V91	R:R:Y416	15.1229	8.83	No	Yes	0	8	8
4	R:R:V91	R:R:W413	14.0434	4.9	No	Yes	0	8	8
5	R:R:I48	R:R:S419	26.2687	4.64	Yes	No	0	8	9
6	R:R:D80	R:R:S419	26.8618	11.78	Yes	No	0	9	9
7	R:R:D80	R:R:N52	100	12.12	Yes	Yes	0	9	9
8	R:R:F50	R:R:G51	95.0589	4.52	No	No	0	5	9
9	R:R:G51	R:R:P423	95.8033	4.06	No	No	0	9	9
10	R:R:N52	R:R:P423	96.5418	13.03	Yes	No	0	9	9
11	R:R:F50	R:R:L54	94.3085	7.31	No	Yes	0	5	8
12	R:R:F437	R:R:L54	89.7352	7.31	No	Yes	0	9	8
13	R:R:A58	R:R:F437	43.7643	2.77	No	No	0	9	9
14	R:R:A58	R:R:F433	41.8513	2.77	No	Yes	0	9	9
15	R:R:F433	R:R:N70	65.3409	8.46	Yes	Yes	0	9	9
16	R:R:F437	R:R:T427	45.3658	10.38	No	Yes	0	9	8
17	R:R:F433	R:R:T427	41.7208	16.86	Yes	Yes	0	9	8
18	R:R:F433	R:R:L65	15.4462	12.18	Yes	No	0	9	9
19	R:R:N70	R:R:T67	18.596	5.85	Yes	No	0	9	8
20	R:R:T67	R:R:Y142	16.4546	6.24	No	Yes	0	8	8
21	R:R:T68	R:R:Y142	24.8747	11.24	Yes	Yes	3	7	8
22	R:R:T68	R:R:V152	25.2365	3.17	Yes	No	0	7	7
23	R:R:V152	R:R:Y71	19.5955	2.52	No	No	0	7	7
24	R:R:Q66	R:R:Y71	13.0706	7.89	No	No	0	8	7
25	R:R:N70	R:R:T69	40.9704	5.85	Yes	No	0	9	8
26	R:R:T69	R:R:Y142	16.4487	6.24	No	Yes	3	8	8
27	R:R:D131	R:R:T69	22.3952	5.78	Yes	No	3	8	8
28	R:R:D131	R:R:T68	12.4981	8.67	Yes	Yes	3	8	7
29	R:R:L125	R:R:Y426	28.0066	5.86	Yes	Yes	1	8	9
30	R:R:F382	R:R:L125	21.2356	7.31	Yes	Yes	1	9	8
31	R:R:F198	R:R:F382	30.8568	5.36	Yes	Yes	1	9	9
32	R:R:F198	R:R:F390	24.4239	25.72	Yes	Yes	1	9	8
33	L:L:?1	R:R:F390	42.9813	7.92	Yes	Yes	1	0	8
34	L:L:?1	R:R:Y416	28.407	12.95	Yes	Yes	1	0	8
35	R:R:D80	R:R:N422	81.4634	10.77	Yes	Yes	0	9	9
36	R:R:L76	R:R:N422	19.1298	12.36	Yes	Yes	1	9	9
37	R:R:L76	R:R:N124	24.1095	8.24	Yes	No	0	9	8
38	L:L:?1	R:R:C118	22.1342	4.13	Yes	No	0	0	8
39	R:R:C118	R:R:W386	22.5702	5.22	No	Yes	0	8	9
40	R:R:N418	R:R:W386	78.978	10.17	Yes	Yes	0	9	9
41	R:R:N418	R:R:N422	76.1871	9.54	Yes	Yes	0	9	9
42	L:L:?1	R:R:F389	22.0601	16.62	Yes	Yes	1	0	8
43	R:R:F389	R:R:W386	36.3407	5.01	Yes	Yes	1	8	9
44	R:R:F390	R:R:W386	23.5549	12.03	Yes	Yes	1	8	9
45	L:L:?1	R:R:V115	26.6483	12.59	Yes	No	0	0	8
46	R:R:S167	R:R:V115	24.6078	6.46	No	No	0	9	8
47	R:R:M116	R:R:S167	22.585	4.6	Yes	No	0	7	9
48	R:R:M116	R:R:M117	10.3598	7.22	Yes	No	0	7	7
49	R:R:I109	R:R:L171	16.941	1.43	No	No	0	6	7
50	R:R:L171	R:R:T112	18.9608	10.32	No	No	0	7	8
51	R:R:L170	R:R:T112	20.9953	4.42	Yes	No	0	8	8
52	R:R:F189	R:R:L170	46.5255	6.09	Yes	Yes	0	8	8
53	R:R:F189	R:R:S193	60.2841	6.61	Yes	No	0	8	9
54	L:L:?1	R:R:S193	61.8946	7.81	Yes	No	0	0	9
55	R:R:D108	R:R:I105	10.6	1.4	No	No	0	6	4
56	R:R:I105	R:R:I109	12.7028	1.47	No	No	0	4	6
57	R:R:F110	R:R:V111	16.6385	5.24	Yes	No	0	7	6
58	R:R:N124	R:R:V159	13.0231	5.91	No	No	0	8	9
59	R:R:F382	R:R:T205	13.465	6.49	Yes	No	0	9	9
60	R:R:S129	R:R:T205	12.6405	9.59	No	No	0	9	9
61	R:R:S129	R:R:Y209	12.0414	15.26	No	Yes	0	9	9
62	R:R:I212	R:R:Y133	11.0419	3.63	No	No	0	9	8
63	R:R:I212	R:R:L375	22.5999	5.71	No	No	0	9	8
64	R:R:L375	R:R:Y209	28.3507	4.69	No	Yes	0	8	9
65	R:R:Y209	R:R:Y426	25.634	4.96	Yes	Yes	1	9	9
66	R:R:I212	R:R:L216	10.339	2.85	No	Yes	0	9	8
67	R:R:F189	R:R:N186	10.2708	10.87	Yes	No	0	8	7
68	R:R:N418	R:R:V381	12.3795	2.96	Yes	No	0	9	7
69	R:R:V381	R:R:V421	11.1457	6.41	No	No	0	7	7
70	R:R:I403	R:R:P404	11.1902	5.08	No	Yes	0	6	6
71	R:R:I403	R:R:Y408	12.5397	4.84	No	No	1	6	5
72	R:R:H393	R:R:Y408	15.028	6.53	Yes	No	1	8	5
73	R:R:L170	R:R:V111	18.2282	4.47	Yes	No	0	8	6
74	R:R:L125	R:R:N422	18.7354	6.87	Yes	Yes	1	8	9
75	R:R:F389	R:R:H393	17.0626	15.84	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D114	R:R:V87	5.84	1	No	No	8	8	1	2
R:R:M88	R:R:Y416	10.78	0	No	Yes	9	8	2	1
R:R:V91	R:R:Y416	8.83	0	No	Yes	8	8	2	1
R:R:D114	R:R:Y416	6.9	1	No	Yes	8	8	1	1
L:L:?1	R:R:D114	16.76	1	Yes	No	0	8	0	1
R:R:S167	R:R:V115	6.46	0	No	No	9	8	2	1
L:L:?1	R:R:V115	12.59	1	Yes	No	0	8	0	1
R:R:C118	R:R:W386	5.22	0	No	Yes	8	9	1	2
L:L:?1	R:R:C118	4.13	1	Yes	No	0	8	0	1
R:R:E181	R:R:I183	5.47	0	No	No	4	5	2	1
L:L:?1	R:R:I183	9.28	1	Yes	No	0	5	0	1
R:R:F189	R:R:S193	6.61	0	Yes	No	8	9	2	1
R:R:H393	R:R:V190	4.15	1	Yes	No	8	7	1	2
L:L:?1	R:R:S193	7.81	1	Yes	No	0	9	0	1
R:R:F390	R:R:S194	6.61	1	Yes	No	8	8	1	2
R:R:F198	R:R:W386	5.01	1	Yes	Yes	9	9	2	2
R:R:F198	R:R:F390	25.72	1	Yes	Yes	9	8	2	1
R:R:F389	R:R:W386	5.01	1	Yes	Yes	8	9	1	2
R:R:F390	R:R:W386	12.03	1	Yes	Yes	8	9	1	2
R:R:F389	R:R:F390	9.65	1	Yes	Yes	8	8	1	1
R:R:F389	R:R:H393	15.84	1	Yes	Yes	8	8	1	1
R:R:F389	R:R:T412	6.49	1	Yes	No	8	8	1	1
L:L:?1	R:R:F389	16.62	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F390	7.92	1	Yes	Yes	0	8	0	1
R:R:H393	R:R:Y408	6.53	1	Yes	No	8	5	1	2
L:L:?1	R:R:H393	5.01	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T412	9.58	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y416	12.95	1	Yes	Yes	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IRS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.11
Number of Linked Nodes	244
Number of Links	266
Number of Hubs	34
Number of Links mediated by Hubs	129
Number of Communities	5
Number of Nodes involved in Communities	37
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	66443
Length Of Smallest Path	3
Average Path Length	15.9665
Length of Longest Path	33
Minimum Path Strength	1.295
Average Path Strength	7.42207
Maximum Path Strength	18.755
Minimum Path Correlation	0.7
Average Path Correlation	0.914375
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	41.4341
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.6182
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • catecholamine binding • dopamine binding • G-protein alpha-subunit binding • monoatomic cation transmembrane transporter activity • channel regulator activity • ion channel regulator activity • monoatomic ion channel activity • potassium ion transmembrane transporter activity • potassium channel activity • potassium channel regulator activity • monoatomic cation channel activity • passive transmembrane transporter activity • inorganic molecular entity transmembrane transporter activity • channel activity • molecular function regulator activity • inorganic cation transmembrane transporter activity • monoatomic ion transmembrane transporter activity • transporter activity • transporter regulator activity • metal ion transmembrane transporter activity • transmembrane transporter activity • heterotrimeric G-protein binding • heterocyclic compound binding • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • signaling receptor activity • identical protein binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • ionotropic glutamate receptor binding • signaling receptor binding • glutamate receptor binding • electron transport chain • metabolic process • generation of precursor metabolites and energy • response to xenobiotic stimulus • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • negative regulation of protein transport • protein localization • regulation of localization • establishment of protein localization • cellular localization • nitrogen compound transport • regulation of protein localization • negative regulation of biological process • negative regulation of transport • protein localization to extracellular region • regulation of secretion by cell • secretion by cell • negative regulation of secretion • cellular macromolecule localization • negative regulation of cellular process • negative regulation of secretion by cell • negative regulation of protein localization • regulation of transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • regulation of cellular localization • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • catabolic process • autophagy • process utilizing autophagic mechanism • response to retinoic acid • cellular response to retinoic acid • response to toxic substance • cellular developmental process • forebrain development • central nervous system neuron development • cell development • substrate-independent telencephalic tangential migration • cerebral cortex GABAergic interneuron differentiation • interneuron migration • neurogenesis • central nervous system neuron differentiation • telencephalon cell migration • forebrain cell migration • neuron differentiation • cell differentiation • substrate-independent telencephalic tangential interneuron migration • cerebral cortex GABAergic interneuron migration • cell migration • cell motility • GABAergic neuron differentiation • head development • interneuron migration from the subpallium to the cortex • neuron migration • forebrain generation of neurons • brain development • nervous system development • cerebral cortex GABAergic interneuron development • generation of neurons • forebrain neuron development • central nervous system development • neuron development • telencephalon development • cerebral cortex neuron differentiation • forebrain neuron differentiation • response to metal ion • response to iron ion • regulation of biosynthetic process • rhythmic process • circadian regulation of gene expression • circadian rhythm • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of metabolic process • regulation of cellular response to hypoxia • cellular response to oxygen levels • cellular response to hypoxia • regulation of cellular response to stress • cellular response to decreased oxygen levels • cellular response to stress • regulation of response to stress • response to stress • response to decreased oxygen levels • negative regulation of response to stimulus • negative regulation of cellular response to hypoxia • regulation of response to stimulus • response to hypoxia • response to oxygen levels • response to abiotic stimulus • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • biogenic amine metabolic process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of glial cell-derived neurotrophic factor production • positive regulation of gene expression • glial cell-derived neurotrophic factor production • positive regulation of multicellular organismal process • positive regulation of cytokine production • positive regulation of glial cell-derived neurotrophic factor production • regulation of potassium ion transport • regulation of monoatomic ion transport • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • cellular response to ethanol • response to ethanol • negative regulation of locomotion • regulation of cell motility • regulation of locomotion • regulation of cell migration • negative regulation of cell motility • negative regulation of cell migration • locomotion • negative regulation of signaling • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of cell communication • trans-synaptic signaling • regulation of signaling • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • negative regulation of synaptic transmission, glutamatergic • response to morphine • response to isoquinoline alkaloid • response to alkaloid • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • monoamine transport • positive regulation of dopamine uptake involved in synaptic transmission • import into cell • regulation of catecholamine uptake involved in synaptic transmission • organic hydroxy compound transport • dopamine transport • catecholamine uptake • positive regulation of amine transport • dopamine uptake involved in synaptic transmission • catecholamine transport • establishment of localization in cell • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • positive regulation of neurotransmitter transport • catecholamine uptake involved in synaptic transmission • regulation of neurotransmitter transport • neurotransmitter transport • amine transport • positive regulation of catecholamine uptake involved in synaptic transmission • positive regulation of transport • positive regulation of neurotransmitter uptake • neurotransmitter uptake • regulation of amine transport • synaptic transmission, dopaminergic • dopamine uptake • adult walking behavior • adult locomotory behavior • behavior • adult behavior • locomotory behavior • walking behavior • acid secretion • response to auditory stimulus • auditory behavior • response to mechanical stimulus • response to external stimulus • mechanosensory behavior • negative adaptation of signaling pathway • receptor internalization • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • vesicle-mediated transport • regulation of G protein-coupled receptor signaling pathway • G protein-coupled receptor internalization • negative regulation of signal transduction • adaptation of signaling pathway • receptor-mediated endocytosis • endocytosis • phospholipase C-activating dopamine receptor signaling pathway • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • peristalsis • muscle system process • neuron-neuron synaptic transmission • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • long-term synaptic potentiation • positive regulation of long-term synaptic potentiation • regulation of synaptic plasticity • positive regulation of synaptic transmission • regulation of long-term synaptic potentiation • morphogenesis of a branching structure • branching morphogenesis of a nerve • sensory perception of smell • regulation of catecholamine secretion • signal release • dopamine secretion • catecholamine secretion • regulation of dopamine secretion • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • negative regulation of hormone secretion • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • negative regulation of peptide secretion • peptide secretion • amide transport • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • cell surface receptor signaling pathway • excitatory postsynaptic potential • regulation of membrane potential • epithelial cell proliferation • renal sodium excretion • inorganic ion homeostasis • regulation of renal system process • homeostatic process • regulation of system process • positive regulation of secretion • monoatomic ion homeostasis • monoatomic cation homeostasis • positive regulation of renal sodium excretion • excretion • sodium ion homeostasis • renal tubular secretion • regulation of renal sodium excretion • chemical homeostasis • regulation of excretion • intracellular calcium ion homeostasis • monoatomic ion transmembrane transport • calcium ion homeostasis • negative regulation of sequestering of calcium ion • calcium ion transport • maintenance of location in cell • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • intracellular chemical homeostasis • regulation of sequestering of calcium ion • intracellular monoatomic ion homeostasis • calcium ion transmembrane import into cytosol • sequestering of calcium ion • inorganic ion transmembrane transport • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • cellular homeostasis • calcium ion transmembrane transport • response to inactivity • multicellular organismal-level homeostasis • temperature homeostasis • learning • learning or memory • cognition • associative learning • response to amine • response to amphetamine • Wnt signaling pathway • negative regulation of neuron migration • regulation of neuron migration • regulation of sodium ion transport • sodium ion transport • grooming behavior • response to estradiol • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • neuroblast proliferation • neural precursor cell proliferation • heart process • regulation of heart contraction • regulation of blood circulation • heart contraction • regulation of heart rate • response to wounding • response to axon injury • endocrine system development • pituitary gland development • gland development • diencephalon development • adenohypophysis development • positive regulation of G protein-coupled receptor signaling pathway • regulation of cellular component organization • regulation of synapse structural plasticity • regulation of synapse organization • cell junction organization • regulation of synapse structure or activity • synapse organization • presynaptic modulation of chemical synaptic transmission • response to light stimulus • response to radiation • negative regulation of amine transport • negative regulation of dopamine secretion • negative regulation of catecholamine secretion • drinking behavior • feeding behavior • response to histamine • startle response • regulation of response to external stimulus • neuromuscular process • prepulse inhibition • negative regulation of response to external stimulus • regulation of neuronal synaptic plasticity • regulation of long-term neuronal synaptic plasticity • regulation of dopamine receptor signaling pathway • negative regulation of dopamine receptor signaling pathway • postsynaptic modulation of chemical synaptic transmission • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of intracellular signal transduction • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • pigmentation • striatum development • subpallium development • regulation of systemic arterial blood pressure • nervous system process involved in regulation of systemic arterial blood pressure • negative regulation of cell population proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • negative regulation of epithelial cell proliferation • cellular component biogenesis • cellular component assembly • cell junction assembly • synapse assembly • negative regulation of behavior • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • negative regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle • negative regulation of circadian rhythm • regulation of circadian rhythm • regulation of behavior • circadian behavior • sleep • negative regulation of multicellular organismal process • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • positive regulation of DNA-templated transcription • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • locomotion involved in locomotory behavior • regulation of locomotion involved in locomotory behavior • orbitofrontal cortex development • limbic system development • behavioral response to cocaine • response to cocaine • regulation of dephosphorylation • negative regulation of metabolic process • dephosphorylation • negative regulation of phosphate metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of phosphorus metabolic process • negative regulation of dephosphorylation • regulation of phosphorus metabolic process • phosphorus metabolic process • synaptic transmission, GABAergic • regulation of synaptic transmission, GABAergic • anatomical structure regression • hyaloid vascular plexus regression • positive regulation of cellular component organization • regulation of receptor internalization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • negative regulation of response to biotic stimulus • response to biotic stimulus • innate immune response • regulation of immune system process • response to external biotic stimulus • immune response • response to other organism • defense response • regulation of innate immune response • negative regulation of immune response • defense response to symbiont • negative regulation of immune system process • immune system process • defense response to other organism • negative regulation of defense response • regulation of immune response • negative regulation of innate immune response • adenylate cyclase-inhibiting dopamine receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • visual learning • visual behavior • behavioral response to ethanol • long-term memory • memory • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of developmental growth • response to nicotine • positive regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of peptide secretion • growth hormone secretion • regulation of growth hormone secretion • positive regulation of peptide hormone secretion • positive regulation of growth hormone secretion • positive regulation of nervous system development • positive regulation of cell population proliferation • regulation of neuroblast proliferation • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of cell differentiation • positive regulation of neurogenesis • regulation of neural precursor cell proliferation • regulation of multicellular organismal development • positive regulation of cell development • positive regulation of neural precursor cell proliferation • positive regulation of neuroblast proliferation • periplasmic space • somatodendritic compartment • cell body • perikaryon • neuronal cell body • Golgi membrane • neuron spine • dendritic spine • postsynapse • dendrite • dendritic tree • acrosomal vesicle • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • GABA-ergic synapse • ciliary membrane • plasma membrane region • cell projection membrane • lateral plasma membrane • postsynaptic membrane • synaptic membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • receptor complex • 9+2 motile cilium • sperm flagellum • motile cilium • presynapse • presynaptic membrane • dopaminergic synapse • endocytic vesicle • glutamatergic synapse • transport vesicle membrane • vesicle membrane • synaptic vesicle • synaptic vesicle membrane • transport vesicle • exocytic vesicle membrane • cytoplasmic vesicle membrane • exocytic vesicle • axon • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	R5F
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	R5F
Name	Rotigotine
Synonyms	(6~{S})-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
Identifier
Formula	C19 H25 N O S
Molecular Weight	315.473
SMILES
PubChem	59227
Formal Charge	0
Total Atoms	47
Total Chiral Atoms	1
Total Bonds	49
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P14416
Sequence	>8IRS_nogp_Chain_R Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E K A L Q T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G E W K F S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M P M L Y N T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G L N N A D Q N E C I I A N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C D C N I P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F R K A F L K I L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8U02	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-	Go/β1/γ2	3.28	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8U02 (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-		3.28	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8TZQ	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-	Go/β1/γ2	3.2	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8TZQ (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-		3.2	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8JD2	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	2.8	2023-06-21	10.1038/s41422-023-00830-2
	8IRS	A	Amine	Dopamine	D₂	Homo sapiens	Rotigotine	-	Gi1/β1/γ2	3	2023-06-07	10.1038/s41422-023-00808-0
	8IRS (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Rotigotine	-		3	2023-06-07	10.1038/s41422-023-00808-0
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	10.1038/s41467-022-28417-2
	7M8W	A	Lipid	Prostanoid	DP₂	Homo sapiens	15r-Methyl-Prostaglandin D2	Na	-	2.61	2021-08-25	10.1073/pnas.2102813118
	7JVR	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-	Gi1/β1/γ2	2.8	2021-02-24	10.1016/j.cell.2021.01.027
	7JVR (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-		2.8	2021-02-24	10.1016/j.cell.2021.01.027
	7DFP	A	Amine	Dopamine	D₂	Homo sapiens	Spiperone	-	-	3.1	2020-12-30	10.1038/s41467-020-20221-0
	6VMS	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-	Gi1/β1/γ2	3.8	2020-06-17	10.1038/s41586-020-2379-5
	6VMS (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-		3.8	2020-06-17	10.1038/s41586-020-2379-5
	6LUQ	A	Amine	Dopamine	D₂	Homo sapiens	Haloperidol	-	-	3.1	2020-03-04	10.1038/s41467-020-14884-y
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	10.1016/j.molcel.2018.08.009
	6D26	A	Lipid	Prostanoid	DP₂	Homo sapiens	Fevipiprant	-	-	2.8	2018-10-03	10.1016/j.molcel.2018.08.009
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	10.1038/nature25758

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