psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L40	R:R:Y37	3.52	No	Yes	0	5	5
2	R:R:L41	R:R:Y37	4.69	No	Yes	5	7	5
3	R:R:E95	R:R:Y37	6.73	No	Yes	0	7	5
4	R:R:W413	R:R:Y37	4.82	Yes	Yes	5	8	5
5	R:R:L41	R:R:W413	20.5	No	Yes	5	7	8
6	R:R:I45	R:R:M88	4.37	No	Yes	0	8	9
7	R:R:A420	R:R:V47	3.39	No	No	0	7	5
8	R:R:A84	R:R:I48	3.25	No	Yes	0	8	8
9	R:R:F50	R:R:L54	6.09	No	No	0	5	8
10	R:R:G51	R:R:P423	4.06	No	No	0	9	9
11	R:R:A77	R:R:N52	4.69	No	Yes	0	9	9
12	R:R:D80	R:R:N52	10.77	Yes	Yes	0	9	9
13	R:R:L81	R:R:N52	4.12	No	Yes	0	8	9
14	R:R:N52	R:R:P423	6.52	Yes	No	0	9	9
15	R:R:I440	R:R:L54	4.28	No	No	0	8	8
16	R:R:T427	R:R:V55	6.35	Yes	No	0	8	9
17	R:R:V59	R:R:V74	4.81	No	No	0	8	7
18	R:R:E62	R:R:L65	11.93	No	Yes	0	8	9
19	R:R:E62	R:R:K439	6.75	No	No	0	8	7
20	R:R:K63	R:R:Q66	4.07	No	No	0	8	8
21	R:R:A64	R:R:E432	4.53	No	No	0	7	7
22	R:R:F433	R:R:L65	13.4	Yes	Yes	0	9	9
23	R:R:Q66	R:R:Y71	7.89	No	Yes	0	8	7
24	R:R:N70	R:R:T67	7.31	No	No	0	9	8
25	R:R:D131	R:R:T68	4.34	Yes	Yes	4	8	7
26	R:R:T68	R:R:Y142	9.99	Yes	Yes	4	7	8
27	R:R:S148	R:R:T68	7.99	No	Yes	0	6	7
28	R:R:D131	R:R:T69	7.23	Yes	No	4	8	8
29	R:R:T69	R:R:Y142	7.49	No	Yes	4	8	8
30	R:R:F433	R:R:N70	12.08	Yes	No	0	9	9
31	R:R:K149	R:R:Y71	3.58	No	Yes	0	6	7
32	R:R:V152	R:R:Y71	3.79	No	Yes	0	7	7
33	R:R:D131	R:R:L72	5.43	Yes	No	0	8	8
34	R:R:N124	R:R:S75	8.94	No	No	0	8	9
35	R:R:S75	R:R:W160	6.18	No	Yes	0	9	9
36	R:R:D80	R:R:L76	6.79	Yes	Yes	6	9	9
37	R:R:L76	R:R:N124	4.12	Yes	No	0	9	8
38	R:R:L125	R:R:L76	5.54	No	Yes	0	8	9
39	R:R:L76	R:R:N422	12.36	Yes	No	6	9	9
40	R:R:D80	R:R:S121	4.42	Yes	No	0	9	9
41	R:R:D80	R:R:S419	11.78	Yes	No	0	9	9
42	R:R:D80	R:R:N422	8.08	Yes	No	6	9	9
43	R:R:L82	R:R:M117	9.9	No	No	0	7	7
44	R:R:D114	R:R:V87	5.84	No	No	0	8	8
45	R:R:M88	R:R:W413	3.49	Yes	Yes	0	9	8
46	R:R:M88	R:R:Y416	9.58	Yes	Yes	0	9	8
47	R:R:H106	R:R:W90	12.7	Yes	No	0	6	6
48	R:R:F110	R:R:W90	10.02	No	No	0	7	6
49	R:R:V91	R:R:W413	6.13	No	Yes	0	8	8
50	R:R:V91	R:R:Y416	6.31	No	Yes	0	8	8
51	R:R:V92	R:R:W413	3.68	No	Yes	0	8	8
52	R:R:V97	R:R:Y93	7.57	No	No	0	5	6
53	R:R:F102	R:R:Y93	6.19	No	No	0	7	6
54	R:R:L94	R:R:W100	3.42	No	Yes	0	7	9
55	R:R:E95	R:R:S409	4.31	No	No	0	7	6
56	R:R:E99	R:R:K101	8.1	No	No	0	4	4
57	R:R:E99	R:R:N180	3.94	No	No	0	4	3
58	R:R:F102	R:R:W100	11.02	No	Yes	2	7	9
59	R:R:H106	R:R:W100	6.35	Yes	Yes	2	6	9
60	R:R:C107	R:R:W100	11.75	No	Yes	2	9	9
61	R:R:C182	R:R:W100	6.53	No	Yes	2	9	9
62	R:R:F102	R:R:H106	6.79	No	Yes	2	7	6
63	R:R:I105	R:R:R104	3.76	No	No	0	4	3
64	R:R:C107	R:R:C182	7.28	No	No	2	9	9
65	R:R:D108	R:R:N175	4.04	No	No	0	6	7
66	L:L:?1	R:R:F110	3.82	Yes	No	0	0	7
67	R:R:L170	R:R:V111	5.96	No	No	0	8	6
68	R:R:N175	R:R:V111	4.43	No	No	0	7	6
69	R:R:I184	R:R:V111	4.61	No	No	0	7	6
70	R:R:L171	R:R:T112	10.32	No	No	0	7	8
71	R:R:D114	R:R:Y416	8.05	No	Yes	1	8	8
72	L:L:?1	R:R:D114	11.06	Yes	No	1	0	8
73	R:R:S167	R:R:V115	3.23	No	No	0	9	8
74	R:R:L170	R:R:V115	4.47	No	No	0	8	8
75	L:L:?1	R:R:V115	12.14	Yes	No	0	0	8
76	R:R:M116	R:R:S163	6.13	No	No	0	7	8
77	R:R:F164	R:R:M116	7.46	No	No	0	6	7
78	R:R:M117	R:R:W160	3.49	No	Yes	0	7	9
79	R:R:C118	R:R:W386	5.22	No	Yes	0	8	9
80	L:L:?1	R:R:C118	5.97	Yes	No	0	0	8
81	R:R:S197	R:R:T119	9.59	No	No	1	8	8
82	L:L:?1	R:R:T119	3.7	Yes	No	1	0	8
83	R:R:A120	R:R:W160	5.19	No	Yes	0	8	9
84	R:R:A120	R:R:S163	3.42	No	No	0	8	8
85	R:R:I122	R:R:P201	3.39	No	Yes	0	9	9
86	R:R:F382	R:R:I122	7.54	Yes	No	3	9	9
87	R:R:I122	R:R:W386	12.92	No	Yes	3	9	9
88	R:R:L123	R:R:V159	4.47	No	No	0	8	9
89	R:R:L123	R:R:L162	5.54	No	No	0	8	7
90	R:R:L123	R:R:P201	3.28	No	Yes	0	8	9
91	R:R:N124	R:R:V159	7.39	No	No	0	8	9
92	R:R:L125	R:R:Y426	8.21	No	Yes	0	8	9
93	R:R:C126	R:R:P201	3.77	Yes	Yes	0	7	9
94	R:R:C126	R:R:V204	3.42	Yes	No	0	7	8
95	R:R:C126	R:R:T205	3.38	Yes	No	0	7	9
96	R:R:I128	R:R:R132	7.52	No	No	0	9	9
97	R:R:S129	R:R:T205	6.4	No	No	0	9	9
98	R:R:S129	R:R:V208	3.23	No	No	0	9	7
99	R:R:S129	R:R:Y209	7.63	No	Yes	0	9	9
100	R:R:D131	R:R:Y142	6.9	Yes	Yes	4	8	8
101	R:R:D131	R:R:R151	7.15	Yes	No	0	8	8
102	R:R:R132	R:R:Y209	7.2	No	Yes	0	9	9
103	R:R:R132	R:R:Y426	7.2	No	Yes	0	9	9
104	R:R:A137	R:R:Y133	6.67	No	Yes	0	8	8
105	R:R:V208	R:R:Y133	3.79	No	Yes	0	7	8
106	R:R:K211	R:R:Y133	5.97	No	Yes	0	7	8
107	R:R:I212	R:R:Y133	4.84	Yes	Yes	0	9	8
108	R:R:R151	R:R:T134	12.94	No	No	0	8	6
109	R:R:A135	R:R:Y142	6.67	No	Yes	0	8	8
110	R:R:V136	R:R:V215	4.81	No	No	0	8	7
111	R:R:L141	R:R:M138	5.65	No	No	0	6	6
112	R:R:M140	R:R:P139	3.35	No	No	0	6	9
113	R:R:S147	R:R:T144	7.99	No	No	0	8	7
114	R:R:I166	R:R:V196	4.61	No	No	0	8	6
115	R:R:I166	R:R:S197	7.74	No	No	0	8	8
116	R:R:C168	R:R:F172	4.19	No	No	0	6	6
117	R:R:F189	R:R:P169	8.67	Yes	No	0	8	8
118	R:R:F189	R:R:L170	8.53	Yes	No	0	8	8
119	R:R:A177	R:R:N175	4.69	No	No	0	4	7
120	R:R:N176	R:R:N186	5.45	No	No	0	7	7
121	R:R:A177	R:R:C182	3.61	No	No	0	4	9
122	L:L:?1	R:R:I183	4.47	Yes	No	0	0	5
123	L:L:?1	R:R:I184	10.74	Yes	No	0	0	7
124	R:R:F189	R:R:N186	4.83	Yes	No	0	8	7
125	R:R:F189	R:R:S193	5.28	Yes	No	0	8	9
126	R:R:H393	R:R:V190	12.45	No	No	0	8	7
127	L:L:?1	R:R:V190	3.74	Yes	No	0	0	7
128	L:L:?1	R:R:S193	4.71	Yes	No	0	0	9
129	R:R:S194	R:R:Y199	6.36	No	No	0	8	7
130	R:R:F390	R:R:S194	6.61	No	No	0	8	8
131	L:L:?1	R:R:S197	4.71	Yes	No	1	0	8
132	R:R:F198	R:R:Y199	7.22	Yes	No	0	9	7
133	R:R:F198	R:R:F202	4.29	Yes	Yes	3	9	7
134	R:R:F198	R:R:F382	5.36	Yes	Yes	3	9	9
135	R:R:F198	R:R:L387	3.65	Yes	No	0	9	7
136	R:R:F198	R:R:F390	30.01	Yes	No	0	9	8
137	R:R:I394	R:R:Y199	10.88	No	No	0	7	7
138	R:R:P201	R:R:V200	3.53	Yes	No	0	9	8
139	R:R:F202	R:R:F382	6.43	Yes	Yes	3	7	9
140	R:R:F202	R:R:I383	5.02	Yes	No	0	7	7
141	R:R:L206	R:R:L379	4.15	No	No	0	6	8
142	R:R:K211	R:R:L207	8.46	No	No	0	7	5
143	R:R:V378	R:R:Y209	6.31	No	Yes	0	9	9
144	R:R:L379	R:R:Y209	9.38	No	Yes	0	8	9
145	R:R:T372	R:R:Y213	7.49	No	No	0	8	7
146	R:R:L375	R:R:Y213	3.52	No	No	0	8	7
147	R:R:E368	R:R:L216	6.63	No	No	0	9	8
148	R:R:K221	R:R:R217	7.43	No	No	0	7	6
149	R:R:E368	R:R:R219	6.98	No	No	0	9	8
150	R:R:Q365	R:R:R220	5.84	No	No	0	5	6
151	R:R:E368	R:R:R220	4.65	No	No	0	9	6
152	R:R:K369	R:R:Q365	4.07	No	No	0	7	5
153	R:R:I377	R:R:Q373	5.49	No	No	0	8	8
154	R:R:F429	R:R:M374	8.71	No	No	0	8	9
155	R:R:I377	R:R:I425	4.42	No	Yes	7	8	8
156	R:R:V378	R:R:Y426	8.83	No	Yes	0	9	9
157	R:R:N418	R:R:V381	4.43	Yes	No	0	9	7
158	R:R:V381	R:R:V421	4.81	No	No	0	7	7
159	R:R:I425	R:R:V381	4.61	Yes	No	0	8	7
160	R:R:F382	R:R:W386	10.02	Yes	Yes	3	9	9
161	R:R:C385	R:R:N418	7.87	No	Yes	0	9	9
162	R:R:N418	R:R:W386	9.04	Yes	Yes	0	9	9
163	R:R:I391	R:R:L387	4.28	No	No	0	7	7
164	R:R:F411	R:R:P388	11.56	No	No	0	5	9
165	R:R:F389	R:R:F411	3.22	No	No	0	8	5
166	R:R:F389	R:R:T412	5.19	No	No	0	8	8
167	L:L:?1	R:R:F389	12.22	Yes	No	0	0	8
168	L:L:?1	R:R:F390	8.4	Yes	No	0	0	8
169	R:R:H393	R:R:I397	7.95	No	No	0	8	6
170	R:R:I403	R:R:N396	11.33	No	No	1	6	5
171	R:R:N396	R:R:Y408	9.3	No	No	1	5	5
172	R:R:C399	R:R:C401	7.28	No	No	0	6	7
173	R:R:I403	R:R:P404	5.08	No	No	0	6	6
174	R:R:I403	R:R:Y408	4.84	No	No	1	6	5
175	R:R:F411	R:R:L407	9.74	No	No	0	5	6
176	L:L:?1	R:R:Y408	9.56	Yes	No	1	0	5
177	R:R:T412	R:R:Y416	4.99	No	Yes	0	8	8
178	L:L:?1	R:R:Y416	4.41	Yes	Yes	1	0	8
179	R:R:N418	R:R:N422	12.26	Yes	No	0	9	9
180	R:R:I424	R:R:T428	4.56	No	No	0	7	7
181	R:R:I425	R:R:Y426	3.63	Yes	Yes	0	8	9
182	R:R:F433	R:R:T427	7.78	Yes	Yes	0	9	8
183	R:R:F437	R:R:T428	7.78	No	No	0	9	7
184	R:R:F433	R:R:N430	6.04	Yes	No	0	9	9
185	R:R:A127	R:R:L72	3.15	No	No	0	7	8
186	R:R:T67	R:R:T68	3.14	No	Yes	0	8	7
187	R:R:I156	R:R:S75	3.1	No	No	0	9	9
188	R:R:I156	R:R:V152	3.07	No	No	0	9	7
189	R:R:I158	R:R:V154	3.07	No	No	0	4	3
190	R:R:A436	R:R:E62	3.02	No	No	0	9	8
191	R:R:F50	R:R:G51	3.01	No	No	0	5	9
192	R:R:L44	R:R:V417	2.98	No	No	0	7	6
193	R:R:L81	R:R:V53	2.98	No	No	0	8	6
194	R:R:L65	R:R:V59	2.98	Yes	No	0	9	8
195	R:R:L86	R:R:T85	2.95	No	No	0	5	6
196	R:R:L407	R:R:T392	2.95	No	No	0	6	5
197	R:R:I210	R:R:I214	2.94	No	No	0	4	5
198	R:R:I130	R:R:M155	2.92	No	No	0	7	8
199	R:R:I48	R:R:L44	2.85	Yes	No	0	8	7
200	R:R:I109	R:R:L113	2.85	No	No	0	6	6
201	R:R:I210	R:R:L206	2.85	No	No	0	4	6
202	R:R:I212	R:R:L375	2.85	Yes	No	0	9	8
203	R:R:I48	R:R:N52	2.83	Yes	Yes	0	8	9
204	R:R:I431	R:R:N430	2.83	No	No	0	5	9
205	R:R:G415	R:R:W386	2.81	No	Yes	0	8	9
206	R:R:L82	R:R:L86	2.77	No	No	0	7	5
207	R:R:L113	R:R:L86	2.77	No	No	0	6	5
208	R:R:H393	R:R:V191	2.77	No	No	0	8	7
209	R:R:H398	R:R:I394	2.65	No	No	0	6	7
210	R:R:R218	R:R:V215	2.62	No	No	0	6	7
211	R:R:A79	R:R:W160	2.59	No	Yes	0	8	9
212	R:R:F437	R:R:T427	2.59	No	Yes	0	9	8
213	R:R:Q365	R:R:Q366	2.56	No	No	0	5	6
214	R:R:V59	R:R:Y71	2.52	No	Yes	0	8	7
215	R:R:V83	R:R:Y416	2.52	No	Yes	0	8	8
216	R:R:I440	R:R:R61	2.51	No	No	0	8	7
217	R:R:M57	R:R:R61	2.48	No	No	0	5	7
218	R:R:N224	R:R:R220	2.41	No	No	0	5	6
219	R:R:R217	R:R:Y213	2.06	No	No	0	6	7
220	R:R:P404	R:R:P405	1.95	No	No	0	6	3
221	R:R:C168	R:R:P169	1.88	No	No	0	6	8
222	R:R:G98	R:R:V97	1.84	No	No	0	5	5
223	R:R:A77	R:R:C56	1.81	No	No	0	9	7
224	R:R:A436	R:R:A58	1.79	No	No	0	9	9
225	R:R:P404	R:R:V406	1.77	No	No	0	6	4
226	R:R:C56	R:R:V78	1.71	No	No	0	7	7
227	R:R:G380	R:R:L379	1.71	No	No	0	7	8
228	R:R:A38	R:R:V96	1.7	No	No	0	7	6
229	R:R:A84	R:R:V49	1.7	No	No	0	8	7
230	R:R:M88	R:R:P89	1.68	Yes	No	0	9	9
231	R:R:M138	R:R:P139	1.68	No	No	0	6	9
232	R:R:C126	R:R:I130	1.64	Yes	No	0	7	7
233	R:R:L174	R:R:P169	1.64	No	No	0	7	8
234	R:R:L414	R:R:P388	1.64	No	No	0	8	9
235	R:R:S147	R:R:S148	1.63	No	No	0	8	6
236	R:R:N186	R:R:P187	1.63	No	No	0	7	4
237	R:R:A420	R:R:I48	1.62	No	Yes	0	7	8
238	R:R:A185	R:R:I183	1.62	No	No	0	7	5
239	R:R:A137	R:R:M138	1.61	No	No	0	8	6
240	R:R:S167	R:R:T112	1.6	No	No	0	9	8
241	R:R:S157	R:R:T153	1.6	No	No	0	5	5
242	R:R:T165	R:R:V161	1.59	No	No	0	5	5
243	R:R:A371	R:R:L216	1.58	No	No	0	9	8
244	R:R:A38	R:R:N35	1.56	No	No	0	7	7
245	R:R:I212	R:R:V136	1.54	Yes	No	0	9	8
246	R:R:I195	R:R:V191	1.54	No	No	0	6	7
247	R:R:I195	R:R:V200	1.54	No	No	0	6	8
248	R:R:I73	R:R:T69	1.52	No	No	0	8	8
249	R:R:I73	R:R:T427	1.52	No	Yes	0	8	8
250	R:R:F172	R:R:G173	1.51	No	No	0	6	7
251	R:R:N35	R:R:T39	1.46	No	No	0	7	6
252	R:R:I212	R:R:L216	1.43	Yes	No	0	9	8
253	R:R:H106	R:R:S103	1.39	Yes	No	0	6	8
254	R:R:E432	R:R:L65	1.33	No	Yes	0	7	9
255	R:R:F202	R:R:I203	1.26	Yes	No	0	7	4
256	R:R:F429	R:R:I377	1.26	No	No	7	8	8
257	R:R:F429	R:R:I425	1.26	No	Yes	7	8	8
258	R:R:D108	R:R:R104	1.19	No	No	0	6	3
259	R:R:Q179	R:R:R104	1.17	No	No	0	1	3
260	R:R:R219	R:R:R222	1.07	No	No	0	8	6
261	R:R:Y34	R:R:Y37	0.99	No	Yes	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y37	4.15	5	5	5
2	R:R:I48	2.6375	4	0	8
3	R:R:N52	5.786	5	0	9
4	R:R:L65	7.41	4	0	9
5	R:R:T68	6.365	4	4	7
6	R:R:Y71	4.445	4	0	7
7	R:R:L76	7.2025	4	6	9
8	R:R:D80	8.368	5	6	9
9	R:R:M88	4.78	4	0	9
10	R:R:W100	7.814	5	2	9
11	R:R:H106	6.8075	4	2	6
12	R:R:C126	3.0525	4	0	7
13	R:R:D131	6.21	5	4	8
14	R:R:Y133	5.3175	4	0	8
15	R:R:Y142	7.7625	4	4	8
16	R:R:W160	4.3625	4	0	9
17	R:R:F189	6.8275	4	0	8
18	R:R:F198	10.106	5	3	9
19	R:R:P201	3.4925	4	0	9
20	R:R:F202	4.25	4	3	7
21	R:R:Y209	7.63	4	0	9
22	R:R:I212	2.665	4	0	9
23	R:R:F382	7.3375	4	3	9
24	R:R:W386	8.002	5	3	9
25	R:R:W413	7.724	5	5	8
26	R:R:Y416	5.97667	6	1	8
27	R:R:N418	8.4	4	0	9
28	R:R:I425	3.48	4	7	8
29	R:R:Y426	6.9675	4	0	9
30	R:R:T427	4.56	4	0	8
31	R:R:F433	9.825	4	0	9
32	L:L:?1	7.11786	14	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W413	R:R:Y37	15.4556	4.82	Yes	Yes	5	8	5
2	R:R:M88	R:R:W413	12.4225	3.49	Yes	Yes	0	9	8
3	R:R:I48	R:R:N52	13.5171	2.83	Yes	Yes	0	8	9
4	R:R:D80	R:R:N52	36.3774	10.77	Yes	Yes	0	9	9
5	R:R:D80	R:R:N422	18.3437	8.08	Yes	No	6	9	9
6	R:R:N418	R:R:N422	59.6927	12.26	Yes	No	0	9	9
7	R:R:N418	R:R:W386	72.7746	9.04	Yes	Yes	0	9	9
8	R:R:C118	R:R:W386	86.5357	5.22	No	Yes	0	8	9
9	L:L:?1	R:R:C118	85.9422	5.97	Yes	No	0	0	8
10	L:L:?1	R:R:Y416	33.9378	4.41	Yes	Yes	1	0	8
11	R:R:M88	R:R:Y416	17.1832	9.58	Yes	Yes	0	9	8
12	R:R:V91	R:R:Y416	13.6687	6.31	No	Yes	0	8	8
13	R:R:V91	R:R:W413	12.317	6.13	No	Yes	0	8	8
14	R:R:G51	R:R:P423	11.084	4.06	No	No	0	9	9
15	R:R:N52	R:R:P423	12.9764	6.52	Yes	No	0	9	9
16	R:R:L76	R:R:N422	41.5996	12.36	Yes	No	6	9	9
17	R:R:L76	R:R:N124	81.7816	4.12	Yes	No	0	9	8
18	R:R:N124	R:R:S75	100	8.94	No	No	0	8	9
19	R:R:I156	R:R:S75	80.9706	3.1	No	No	0	9	9
20	R:R:I156	R:R:V152	79.4145	3.07	No	No	0	9	7
21	R:R:V152	R:R:Y71	77.7595	3.79	No	Yes	0	7	7
22	R:R:V59	R:R:Y71	71.2647	2.52	No	Yes	0	8	7
23	R:R:L65	R:R:V59	68.2514	2.98	Yes	No	0	9	8
24	R:R:F433	R:R:L65	57.1278	13.4	Yes	Yes	0	9	9
25	R:R:F433	R:R:T427	27.2254	7.78	Yes	Yes	0	9	8
26	R:R:F433	R:R:N70	25.2802	12.08	Yes	No	0	9	9
27	R:R:N70	R:R:T67	23.3812	7.31	No	No	0	9	8
28	R:R:T67	R:R:T68	21.4691	3.14	No	Yes	0	8	7
29	R:R:I73	R:R:T69	15.8512	1.52	No	No	0	8	8
30	R:R:I73	R:R:T427	17.6975	1.52	No	Yes	0	8	8
31	R:R:S75	R:R:W160	24.7593	6.18	No	Yes	0	9	9
32	R:R:L125	R:R:L76	44.8965	5.54	No	Yes	0	8	9
33	R:R:M117	R:R:W160	12.6137	3.49	No	Yes	0	7	9
34	R:R:L82	R:R:M117	10.5433	9.9	No	No	0	7	7
35	R:R:H106	R:R:W90	15.9502	12.7	Yes	No	0	6	6
36	R:R:F110	R:R:W90	17.4931	10.02	No	No	0	7	6
37	L:L:?1	R:R:F110	18.7459	3.82	Yes	No	0	0	7
38	R:R:N175	R:R:V111	11.6313	4.43	No	No	0	7	6
39	R:R:I184	R:R:V111	11.9016	4.61	No	No	0	7	6
40	L:L:?1	R:R:I184	13.1346	10.74	Yes	No	0	0	7
41	R:R:I122	R:R:W386	27.7529	12.92	No	Yes	3	9	9
42	R:R:I122	R:R:P201	36.562	3.39	No	Yes	0	9	9
43	R:R:F198	R:R:F382	12.6665	5.36	Yes	Yes	3	9	9
44	R:R:L123	R:R:P201	25.267	3.28	No	Yes	0	8	9
45	R:R:L123	R:R:V159	24.4362	4.47	No	No	0	8	9
46	R:R:N418	R:R:V381	17.1766	4.43	Yes	No	0	9	7
47	R:R:I425	R:R:V381	15.5941	4.61	Yes	No	0	8	7
48	R:R:I425	R:R:Y426	16.4579	3.63	Yes	Yes	0	8	9
49	R:R:C126	R:R:P201	43.4393	3.77	Yes	Yes	0	7	9
50	R:R:C126	R:R:T205	38.9753	3.38	Yes	No	0	7	9
51	R:R:R132	R:R:Y426	27.6803	7.2	No	Yes	0	9	9
52	R:R:S129	R:R:T205	38.1841	6.4	No	No	0	9	9
53	R:R:S129	R:R:V208	67.836	3.23	No	No	0	9	7
54	R:R:S129	R:R:Y209	43.1623	7.63	No	Yes	0	9	9
55	R:R:R132	R:R:Y209	25.9	7.2	No	Yes	0	9	9
56	R:R:V378	R:R:Y426	26.6385	8.83	No	Yes	0	9	9
57	R:R:V378	R:R:Y209	25.6297	6.31	No	Yes	0	9	9
58	R:R:A137	R:R:Y133	13.1149	6.67	No	Yes	0	8	8
59	R:R:V208	R:R:Y133	65.5413	3.79	No	Yes	0	7	8
60	R:R:I212	R:R:Y133	46.7097	4.84	Yes	Yes	0	9	8
61	R:R:A137	R:R:M138	10.5169	1.61	No	No	0	8	6
62	R:R:F189	R:R:S193	13.8995	5.28	Yes	No	0	8	9
63	L:L:?1	R:R:S193	15.1457	4.71	Yes	No	0	0	9
64	R:R:L206	R:R:L379	10.1015	4.15	No	No	0	6	8
65	R:R:L379	R:R:Y209	16.715	9.38	No	Yes	0	8	9
66	R:R:I212	R:R:L375	12.6137	2.85	Yes	No	0	9	8
67	R:R:L375	R:R:Y213	10.207	3.52	No	No	0	8	7
68	R:R:E368	R:R:L216	20.48	6.63	No	No	0	9	8
69	R:R:I212	R:R:L216	24.9242	1.43	Yes	No	0	9	8
70	R:R:E368	R:R:R220	13.0951	4.65	No	No	0	9	6
71	L:L:?1	R:R:F389	11.0972	12.22	Yes	No	0	0	8
72	R:R:D80	R:R:L76	23.1109	6.79	Yes	Yes	6	9	9
73	R:R:N124	R:R:V159	24.1857	7.39	No	No	0	8	9
74	R:R:L125	R:R:Y426	44.1382	8.21	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D114	R:R:V87	5.84	1	No	No	8	8	1	2
R:R:M88	R:R:Y416	9.58	0	Yes	Yes	9	8	2	1
R:R:F110	R:R:W90	10.02	0	No	No	7	6	1	2
R:R:V91	R:R:Y416	6.31	0	No	Yes	8	8	2	1
L:L:?1	R:R:F110	3.82	1	Yes	No	0	7	0	1
R:R:L170	R:R:V111	5.96	0	No	No	8	6	2	2
R:R:I184	R:R:V111	4.61	0	No	No	7	6	1	2
R:R:D114	R:R:Y416	8.05	1	No	Yes	8	8	1	1
L:L:?1	R:R:D114	11.06	1	Yes	No	0	8	0	1
R:R:S167	R:R:V115	3.23	0	No	No	9	8	2	1
R:R:L170	R:R:V115	4.47	0	No	No	8	8	2	1
L:L:?1	R:R:V115	12.14	1	Yes	No	0	8	0	1
R:R:C118	R:R:W386	5.22	0	No	Yes	8	9	1	2
L:L:?1	R:R:C118	5.97	1	Yes	No	0	8	0	1
R:R:S197	R:R:T119	9.59	1	No	No	8	8	1	1
L:L:?1	R:R:T119	3.7	1	Yes	No	0	8	0	1
R:R:I166	R:R:S197	7.74	0	No	No	8	8	2	1
R:R:F189	R:R:L170	8.53	0	Yes	No	8	8	2	2
L:L:?1	R:R:I183	4.47	1	Yes	No	0	5	0	1
L:L:?1	R:R:I184	10.74	1	Yes	No	0	7	0	1
R:R:F189	R:R:S193	5.28	0	Yes	No	8	9	2	1
R:R:H393	R:R:V190	12.45	0	No	No	8	7	2	1
L:L:?1	R:R:V190	3.74	1	Yes	No	0	7	0	1
L:L:?1	R:R:S193	4.71	1	Yes	No	0	9	0	1
R:R:F390	R:R:S194	6.61	0	No	No	8	8	1	2
L:L:?1	R:R:S197	4.71	1	Yes	No	0	8	0	1
R:R:F198	R:R:F390	30.01	3	Yes	No	9	8	2	1
R:R:F389	R:R:F411	3.22	0	No	No	8	5	1	2
R:R:F389	R:R:T412	5.19	0	No	No	8	8	1	2
L:L:?1	R:R:F389	12.22	1	Yes	No	0	8	0	1
L:L:?1	R:R:F390	8.4	1	Yes	No	0	8	0	1
R:R:I403	R:R:N396	11.33	1	No	No	6	5	2	2
R:R:N396	R:R:Y408	9.3	1	No	No	5	5	2	1
R:R:I403	R:R:Y408	4.84	1	No	No	6	5	2	1
L:L:?1	R:R:Y408	9.56	1	Yes	No	0	5	0	1
R:R:T412	R:R:Y416	4.99	0	No	Yes	8	8	2	1
L:L:?1	R:R:Y416	4.41	1	Yes	Yes	0	8	0	1
R:R:V83	R:R:Y416	2.52	0	No	Yes	8	8	2	1
R:R:A185	R:R:I183	1.62	0	No	No	7	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7JVR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	243
Number of Links	261
Number of Hubs	32
Number of Links mediated by Hubs	127
Number of Communities	7
Number of Nodes involved in Communities	31
Number of Links involved in Communities	36

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	36699
Length Of Smallest Path	3
Average Path Length	13.4297
Length of Longest Path	28
Minimum Path Strength	1.18
Average Path Strength	6.05321
Maximum Path Strength	19.205
Minimum Path Correlation	0.7
Average Path Correlation	0.918087
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	45.2953
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.649
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	08Y
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	08Y
Name	Bromocriptine
Synonyms	2-bromo-α-ergokryptine
Identifier
Formula	C32 H40 Br N5 O5
Molecular Weight	654.594
SMILES
PubChem	31101
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	6
Total Bonds	89
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P14416
Sequence	>7JVR_nogp_Chain_R Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E K A L Q T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G E W K F S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M P M L Y N T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G L N N A D Q N E C I I A N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C D C N I P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F R K A F L K I L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7JVR	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-	Gi1/β1/γ2	2.8	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	7JVR (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-		2.8	2021-02-24	doi.org/10.1016/j.cell.2021.01.027
	6CM4	A	Amine	Dopamine	D₂	Homo sapiens	Risperidone	-	-	2.87	2018-03-14	doi.org/10.1038/nature25758
	8IRS	A	Amine	Dopamine	D₂	Homo sapiens	Rotigotine	-	Gi1/β1/γ2	3	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRS (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Rotigotine	-		3	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	6LUQ	A	Amine	Dopamine	D₂	Homo sapiens	Haloperidol	-	-	3.1	2020-03-04	doi.org/10.1038/s41467-020-14884-y
	7DFP	A	Amine	Dopamine	D₂	Homo sapiens	Spiperone	-	-	3.1	2020-12-30	doi.org/10.1038/s41467-020-20221-0
	6VMS	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-	Gi1/β1/γ2	3.8	2020-06-17	doi.org/10.1038/s41586-020-2379-5
	6VMS (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	Bromoergocryptine	-		3.8	2020-06-17	doi.org/10.1038/s41586-020-2379-5
	8TZQ	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-	Go/β1/γ2	3.2	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8TZQ (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-		3.2	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8U02	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-	Go/β1/γ2	3.28	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	8U02 (No Gprot)	A	Amine	Dopamine	D₂	Homo sapiens	L-Dopamine	-		3.28	2024-08-21	doi.org/10.1038/s41467-024-50964-z
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7TD2	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-	Gi1/β1/γ2	3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD2 (No Gprot)	A	Lipid	Lysophospholipid	LPA₁	Homo sapiens	LPA	-		3.11	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	8JD2	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	-	-	2.8	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8ZW0	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-	Gs/β1/γ2	2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	8ZW0 (No Gprot)	A	Lipid	Prostaglandin	DP₁	Homo sapiens	PGD2	-		2.72	2025-05-28	doi.org/10.1073/pnas.2501902122
	7M8W	A	Lipid	Prostanoid	DP₂	Homo sapiens	15r-Methyl-Prostaglandin D2	Na	-	2.61	2021-08-25	doi.org/10.1073/pnas.2102813118
	6D26	A	Lipid	Prostanoid	DP₂	Homo sapiens	Fevipiprant	-	-	2.8	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009

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