Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 9.4575434
2A:A:H41 10.46466
3A:A:R42 11.02419
4A:A:L46 4.436518
5A:A:V217 8.115465
6A:A:F219 5.97429768
7A:A:H220 12.56417
8A:A:F222 10.5067617
9A:A:Q227 7.092519
10A:A:K233 8.45667619
11A:A:W234 8.594519
12A:A:C237 5.71418
13A:A:F238 13.1625409
14A:A:I245 5.8075407
15A:A:N264 5.45754189
16A:A:L272 6.365418
17A:A:F273 6.63714719
18A:A:W277 9.64667616
19A:A:W281 13.212515
20A:A:L282 6.3125409
21A:A:I288 5.64409
22A:A:F290 7.3025119
23A:A:E314 5.1975416
24A:A:F315 11.26506
25A:A:Y318 8.23416
26A:A:P326 6.86511
27A:A:K338 13.334515
28A:A:Y339 8.03613
29A:A:F340 9.17167617
30A:A:R342 8.648514
31A:A:D343 8.1925413
32A:A:E344 6.518515
33A:A:F345 12.6408
34A:A:L346 6.496514
35A:A:S349 5.8975417
36A:A:Y358 17.755464
37A:A:Y360 12.376568
38A:A:N371 8.714119
39A:A:R373 7.54405
40A:A:R374 8.9945114
41A:A:F376 7.04333668
42A:A:D381 8.8468
43A:A:Q384 4.69566
44A:A:R385 15.206565
45A:A:H387 6.04754108
46A:A:L388 5.53754198
47A:A:Q390 8.554104
48A:A:Y391 11.574104
49A:A:E392 8.745426
50A:A:L393 5.974198
51A:A:L394 5.6175408
52B:B:I18 4.4725407
53B:B:L30 5.365405
54B:B:V40 4.185403
55B:B:M45 5.695454
56B:B:L51 7.924539
57B:B:H54 9.548539
58B:B:K57 15.03419
59B:B:M61 5.255436
60B:B:W63 6.37667637
61B:B:R68 10.7375435
62B:B:L70 7.0075435
63B:B:Q75 10.494519
64B:B:D76 8.465409
65B:B:I81 7.0854147
66B:B:W82 10.3314739
67B:B:D83 11.3375438
68B:B:N88 9.9275437
69B:B:K89 6.51714739
70B:B:I93 7.1145127
71B:B:L95 4.42754128
72B:B:W99 11.395619
73B:B:M101 6.35519
74B:B:Y105 8.0365146
75B:B:L117 5.474519
76B:B:I123 4.59406
77B:B:Y124 9.12254126
78B:B:L126 75145
79B:B:E138 6.3025406
80B:B:H142 10.412599
81B:B:Y145 7.9618
82B:B:F151 7.26167609
83B:B:L152 9.2875403
84B:B:D163 9.69499
85B:B:W169 11.0767698
86B:B:F180 7.225677
87B:B:H183 8.10333679
88B:B:V187 5.84479
89B:B:V200 9.58446
90B:B:C204 7.54417
91B:B:D205 6.142579
92B:B:K209 9.898576
93B:B:L210 5.6025445
94B:B:W211 8.64778
95B:B:Q220 8.5275407
96B:B:H225 9.48167649
97B:B:D228 7.49619
98B:B:N230 7.23419
99B:B:I232 5.4775448
100B:B:F234 5.7325445
101B:B:F235 9.3754226
102B:B:P236 5.644227
103B:B:N237 9.065405
104B:B:F241 8.748546
105B:B:T243 7.76448
106B:B:D246 6.218519
107B:B:D247 10.6425449
108B:B:R251 13.57448
109B:B:F253 7.2525446
110B:B:D254 5.8025239
111B:B:R256 7.5965239
112B:B:M262 4.545404
113B:B:Y264 6.382505
114B:B:L285 5.095406
115B:B:Y289 8.367147157
116B:B:D290 8.8925416
117B:B:D291 5.45254158
118B:B:N295 7.9785156
119B:B:D298 5.81754209
120B:B:L300 5.8725406
121B:B:K301 6.3254205
122B:B:H311 13.6459
123B:B:R314 12.62518
124B:B:T321 6.02537
125B:B:W332 13.4757719
126B:B:L336 6.526537
127B:B:K337 9.125456
128B:B:W339 10.258559
129B:B:N340 10.4925439
130G:G:L19 3.4775409
131G:G:D48 6.92833659
132G:G:L50 4.9575459
133G:G:L51 6.135456
134G:G:F61 7.52738
135R:R:F601 6.54529
136R:R:L604 7.26429
137R:R:L605 6.902527
138R:R:R609 12.4925427
139R:R:Q616 8.1575407
140R:R:F634 12.165489
141R:R:Y642 6.4025409
142R:R:F645 4.4575489
143R:R:K647 8.52489
144R:R:P653 10.844109
145R:R:I656 5.466509
146R:R:F671 8.878529
147R:R:L679 6.2365138
148R:R:L693 6.718529
149R:R:H694 8.86667629
150R:R:Y695 6.4054169
151R:R:L697 8.925429
152R:R:F701 10.43429
153R:R:W703 10.1125169
154R:R:H710 7.6885109
155R:R:L713 6.324245
156R:R:F719 10.074569
157R:R:Y722 10.3354176
158R:R:Y726 10.23508
159R:R:F730 8.3725408
160R:R:W735 8.9365169
161R:R:N752 5.604528
162R:R:Y753 7.21667629
163R:R:F769 9.895629
164R:R:C770 5.94254139
165R:R:W771 7.24429729
166R:R:I772 5.8625428
167R:R:V777 7.715427
168R:R:F778 10.906529
169R:R:T781 4.56507
170R:R:F786 11.0825429
171R:R:F790 9.1429
172R:R:F797 9.6625409
173R:R:D823 6.325407
174R:R:R825 7.6925429
175R:R:F832 9.18426
176R:R:T837 7.6625429
177R:R:W838 8.84125829
178R:R:F840 6.49429
179R:R:Y854 6.225409
180R:R:F856 6.1975429
181R:R:F859 6.1025428
182R:R:Q863 7.7325429
183R:R:F865 9.455407
184R:R:F868 7.52789
185R:R:F870 4.80167629
186R:R:Q881 8.84489
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:Q19 B:B:N88 11.412813.2YesYes347
2A:A:Q19 B:B:V90 12.67834.3YesNo045
3A:A:N23 B:B:N88 12.79749.54NoYes377
4A:A:N23 B:B:K89 12.95124.2NoYes379
5A:A:L30 B:B:K78 13.65292.82NoNo058
6A:A:L30 B:B:K89 13.53812.82NoYes059
7B:B:D76 B:B:K78 14.11228.3YesNo098
8A:A:Y37 B:B:D76 88.01115.75NoYes049
9A:A:R42 A:A:Y37 88.237421.61YesNo094
10A:A:Y358 A:A:Y360 22.377716.88YesYes648
11A:A:Y358 R:R:Q812 98.716315.78YesNo048
12A:A:L346 R:R:Q812 98.78087.99YesNo048
13A:A:L346 A:A:S349 1004.5YesYes147
14A:A:F273 A:A:S349 68.51215.28YesYes197
15A:A:F246 A:A:F273 38.09364.29NoYes199
16A:A:F246 A:A:L46 35.35027.31NoYes198
17A:A:L44 A:A:L46 32.74054.15NoYes098
18A:A:F238 A:A:L44 96.644226.79YesNo099
19A:A:F238 B:B:W99 89.896615.03YesYes099
20A:A:R42 B:B:W99 88.21527YesYes199
21A:A:R380 R:R:F719 10.27836.41NoYes679
22A:A:Q384 A:A:R380 10.51044.67YesNo667
23A:A:D381 A:A:Q384 36.20215.22YesYes686
24A:A:D381 A:A:Y360 18.427111.49YesYes688
25A:A:D381 A:A:R385 18.076514.29YesYes685
26A:A:R385 A:A:Y358 76.209328.81YesYes654
27A:A:F273 A:A:V287 32.81425.24YesNo196
28A:A:I244 A:A:V287 64.20916.14NoNo086
29A:A:I244 A:A:L44 64.01285.71NoNo089
30A:A:S349 A:A:W277 31.5028.65YesYes176
31A:A:V287 A:A:W277 31.4514.9NoYes166
32A:A:R385 A:A:R389 29.47465.33YesNo054
33A:A:R385 R:R:I807 29.241516.28YesNo658
34A:A:Q384 R:R:Q803 25.42013.84YesNo069
35A:A:L394 A:A:R389 29.17697.29YesNo084
36A:A:L394 R:R:I807 29.66945.71YesNo088
37A:A:Y391 R:R:H710 11.855510.89YesYes1049
38R:R:Q803 R:R:V716 24.58725.73NoNo099
39R:R:V716 R:R:Y712 24.3855.05NoNo099
40R:R:F709 R:R:Y712 20.14244.13NoNo079
41R:R:F709 R:R:F730 16.37954.29NoYes078
42A:A:Y391 R:R:M711 15.211711.97YesNo049
43A:A:L394 R:R:Q822 55.40255.32YesNo087
44R:R:Q822 R:R:R825 50.64765.84NoYes279
45B:B:T321 B:B:W63 69.39219.7YesYes377
46B:B:G324 B:B:T321 68.88453.64NoYes097
47B:B:G324 G:G:P49 68.75734.06NoNo097
48G:G:D48 G:G:P49 68.63014.83YesNo097
49G:G:D48 G:G:L50 53.52475.43YesYes599
50B:B:M45 G:G:L50 53.26954.24YesYes549
51B:B:L286 B:B:M45 49.85954.24NoYes074
52B:B:L286 B:B:V327 49.040910.43NoNo076
53B:B:V320 B:B:V327 48.90568.02NoNo076
54B:B:S277 B:B:V320 48.77174.85NoNo057
55B:B:C233 B:B:S277 48.51013.44NoNo035
56B:B:C233 B:B:S191 48.38173.44NoNo038
57B:B:F234 B:B:S191 48.2546.61YesNo058
58B:B:F234 B:B:V200 23.10027.87YesYes456
59B:B:L210 B:B:V200 20.42345.96YesYes456
60B:B:L210 B:B:Q220 19.38473.99YesYes057
61B:B:D258 B:B:Q220 38.340111.75NoYes077
62B:B:D258 B:B:R22 35.64768.34NoNo076
63B:B:I18 B:B:R22 34.14875.01YesNo076
64B:B:L70 B:B:W82 67.94544.56YesYes359
65B:B:L70 B:B:W63 67.592613.67YesYes357
66B:B:F234 B:B:F241 24.77154.29YesYes456
67B:B:F222 B:B:F241 19.49439.65NoYes486
68B:B:F222 B:B:Q220 19.853112.88NoYes087
69B:B:I18 G:G:E22 27.22558.2YesNo079
70G:G:D48 G:G:L51 14.82669.5YesYes596
71B:B:V40 G:G:L51 14.51637.45YesYes036
72B:B:D298 B:B:V40 14.04454.38YesYes093
73B:B:D298 B:B:R283 13.20497.15YesNo099
74B:B:L300 B:B:R283 12.92597.29YesNo069
75B:B:L30 B:B:L300 12.22825.54YesYes056
76B:B:H54 B:B:W82 71.34389.52YesYes399
77B:B:H54 B:B:S74 72.42512.55YesNo099
78B:B:T221 G:G:E22 16.21548.47NoNo079
79B:B:K209 B:B:T221 15.911610.51YesNo067
80B:B:F180 B:B:W211 13.47715.03YesYes778
81G:G:E22 G:G:Q18 10.70837.65NoNo099
82B:B:H91 B:B:V90 12.5178.3NoNo055
83R:R:F870 R:R:R825 50.50284.28YesYes299
84R:R:F832 R:R:F870 42.82695.36YesYes269
85R:R:F832 R:R:T837 41.09337.78YesYes269
86R:R:N860 R:R:T837 39.82477.31NoYes299
87R:R:N860 R:R:W838 34.750323.73NoYes299
88R:R:F601 R:R:W838 14.59096.01YesYes299
89R:R:F601 R:R:F671 11.064610.72YesYes299
90R:R:F701 R:R:W838 15.7346.01YesYes299
91R:R:F701 R:R:L697 14.110813.4YesYes299
92R:R:L697 R:R:W771 13.4435.69YesYes299
93B:B:D76 B:B:S74 72.535510.31YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WUQ
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRG2
Species Mus musculus
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.9
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04590-8
Net Summary
Imin 3.82
Number of Linked Nodes 844
Number of Links 1049
Number of Hubs 186
Number of Links mediated by Hubs 671
Number of Communities 24
Number of Nodes involved in Communities 266
Number of Links involved in Communities 390
Path Summary
Number Of Nodes in MetaPath 94
Number Of Links MetaPath 93
Number of Shortest Paths 2808774
Length Of Smallest Path 3
Average Path Length 38.418
Length of Longest Path 75
Minimum Path Strength 1.285
Average Path Strength 8.62946
Maximum Path Strength 22.545
Minimum Path Correlation 0.7
Average Path Correlation 0.983075
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 35.5286
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 57.0797
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7WUQ_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGSGIFET 
KFQVDKVNF HMFDVGAQR DERRKWIQC FNDVTAIIF VVASSSTNR 
LQAALKLFD SIWNNKWLR DTSVILFLN KQDLLAEKV LAGKIEDYF 
PEFARYTTP EDATPEPGE DPRVTRAKY FIRDEFLRI STASGDGRH 
YCYPHFTVD TENIRRVFN DCRDIIQRM HLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WUQ_Chain_B
LRQEAEQLK NQIRDARKA CADATLSQI TNNIDPVGR IQMRTRRTL 
RGHLAKIYA MHWGTDSRL LVSASQDGK LIIWDSYTT NKVHAIPLR 
SSWVMTCAY APSGNYVAC GGLDNICSI YNLKTREGN VRVSRELAG 
HTGYLSCCR FLDDNQIVT SSGDTTCAL WDIETGQQT TTFTGHTGD 
VMSLSLAPD TRLFVSGAC DASAKLWDV REGMCRQTF TGHESDINA 
ICFFPNGNA FATGSDDAT CRLFDLRAD QELMTYSHD NIICGITSV 
SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT 
DDGMAVATG SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WUQ_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8CJ12
Sequence
>7WUQ_Chain_R
HLTSFGILL DLSRTSLPP SQMMALTFI TYIGCGLSS IFLSVTLVT 
YIAFEKIRR DYPSKILIQ LCAALLLLN LIFLLDSWI ALYNTRGFC 
IAVAVFLHY FLLVSFTWM GLEAFHMYL ALVKVFNTY IRKYILKFC 
IVGWGIPAV VVSIVLTIS PDNYGIGSD FCWINSNVV FYITVVGYF 
CVIFLLNVS MFIVVLVQL CRIKKKKQL GAQRKTSIQ DLRSIAGLT 
FLLGITWGF AFFAWPVNV TFMYLFAIF NTLQGFFIF IFYCAAKEN 
VRKQWRRY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WUIB2AdhesionAdhesionADGRG2Mus musculusIP15-chim(NtGi1-Gs)/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04590-8
7WUQB2AdhesionAdhesionADGRG2Mus musculus--Gs/&β;1/&γ;22.92022-04-2710.1038/s41586-022-04590-8
7XKDB2AdhesionAdhesionADGRG2Mus musculusBetahydroxyandrosterone-Gs/&β;1/&γ;22.42022-08-1010.1038/s41589-022-01084-6
7XKEB2AdhesionAdhesionADGRG2Mus musculusBetahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;22.92022-08-1010.1038/s41589-022-01084-6
7XKFB2AdhesionAdhesionADGRG2Mus musculusBetahydroxyandrosterone-Gs/&β;1/&γ;22.42022-08-1010.1038/s41589-022-01084-6
7YP7B2AdhesionAdhesionADGRG2Mus musculus--Gs/&β;1/&γ;23.12022-08-2410.1038/s41589-022-01084-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WUQ.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.