psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L620	R:R:Y854	3.52	Yes	Yes	0	9	9
2	L:L:?1	R:R:L620	4.13	Yes	Yes	1	0	9
3	R:R:F622	R:R:I626	5.02	No	No	0	6	9
4	R:R:T624	R:R:T861	4.71	No	Yes	1	9	8
5	L:L:?1	R:R:T624	11.73	Yes	No	1	0	9
6	R:R:S675	R:R:Y625	8.9	No	No	0	7	8
7	R:R:G627	R:R:T861	3.64	No	Yes	0	9	8
8	R:R:C628	R:R:L672	4.76	No	No	0	9	9
9	R:R:N668	R:R:S631	4.47	No	No	0	9	9
10	R:R:G864	R:R:S631	3.71	No	No	0	9	9
11	R:R:L669	R:R:S632	4.5	No	No	0	8	9
12	R:R:F634	R:R:F865	10.72	No	Yes	0	9	7
13	R:R:F634	R:R:F868	18.22	No	Yes	0	9	9
14	R:R:L635	R:R:L665	4.15	No	No	0	9	8
15	R:R:G864	R:R:L635	5.13	No	No	0	9	9
16	R:R:F868	R:R:T638	6.49	Yes	No	6	9	9
17	R:R:C872	R:R:T638	8.45	No	No	6	9	9
18	R:R:C872	R:R:T641	5.07	No	No	0	9	9
19	R:R:T641	R:R:W882	13.34	No	No	0	9	9
20	R:R:I648	R:R:Y642	9.67	No	Yes	0	8	9
21	R:R:S654	R:R:Y642	3.82	No	Yes	0	9	9
22	R:R:L657	R:R:Y642	4.69	No	Yes	0	9	9
23	R:R:I658	R:R:Y642	7.25	No	Yes	0	9	9
24	R:R:K875	R:R:Y642	3.58	No	Yes	0	9	9
25	R:R:A644	R:R:F645	4.16	No	No	0	7	9
26	R:R:F645	R:R:Q881	8.2	No	No	0	9	9
27	R:R:E646	R:R:R649	10.47	No	No	0	6	9
28	R:R:E646	R:R:R650	15.12	No	No	0	6	8
29	R:R:K647	R:R:Q881	8.14	No	No	0	9	9
30	R:R:I648	R:R:Q881	4.12	No	No	0	8	9
31	R:R:D651	R:R:P653	8.05	No	No	0	9	9
32	R:R:D651	R:R:S654	8.83	No	No	0	9	9
33	R:R:H710	R:R:Y652	4.36	Yes	No	3	9	8
34	R:R:Y652	R:R:Y726	20.85	No	Yes	3	8	8
35	R:R:I727	R:R:Y652	7.25	No	No	0	8	8
36	R:R:H710	R:R:P653	9.15	Yes	No	0	9	9
37	R:R:I727	R:R:K655	13.09	No	No	0	8	9
38	R:R:E707	R:R:I656	6.83	No	No	3	9	9
39	R:R:H710	R:R:I656	5.3	Yes	No	3	9	9
40	R:R:F730	R:R:I656	3.77	Yes	No	0	8	9
41	R:R:L657	R:R:Y871	5.86	No	No	0	9	8
42	R:R:Q659	R:R:W703	15.33	No	Yes	2	7	9
43	R:R:C731	R:R:Q659	6.1	No	No	2	8	7
44	R:R:Q659	R:R:W735	4.38	No	Yes	2	7	9
45	R:R:L660	R:R:L664	4.15	No	No	0	9	9
46	R:R:L664	R:R:S700	7.51	No	No	0	9	7
47	R:R:L664	R:R:Q863	5.32	No	Yes	0	9	9
48	R:R:F696	R:R:L666	14.61	Yes	No	0	9	5
49	R:R:L667	R:R:N668	4.12	No	No	0	9	9
50	R:R:L667	R:R:L697	4.15	No	No	0	9	9
51	R:R:F696	R:R:I670	8.79	Yes	No	0	9	6
52	R:R:F671	R:R:F769	4.29	No	Yes	0	9	9
53	L:L:?1	R:R:F671	16.96	Yes	No	0	0	9
54	R:R:D674	R:R:V689	5.84	No	No	0	9	8
55	R:R:D674	R:R:F769	14.33	No	Yes	0	9	9
56	R:R:C770	R:R:D674	6.22	No	No	0	9	9
57	R:R:I677	R:R:W676	7.05	No	No	0	8	9
58	R:R:I677	R:R:L679	5.71	No	Yes	0	8	8
59	R:R:L679	R:R:T682	4.42	Yes	No	0	8	4
60	R:R:N681	R:R:Y680	4.65	No	No	0	3	8
61	R:R:F685	R:R:T682	11.67	No	No	0	8	4
62	R:R:I687	R:R:R683	6.26	No	No	0	9	5
63	R:R:D751	R:R:R683	9.53	No	No	0	4	5
64	R:R:C686	R:R:I755	4.91	No	No	0	9	6
65	R:R:C686	R:R:C770	7.28	No	No	7	9	9
66	R:R:A690	R:R:Y753	4	No	Yes	0	9	9
67	R:R:L746	R:R:V691	7.45	No	No	4	8	6
68	R:R:V691	R:R:Y753	11.36	No	Yes	4	6	9
69	R:R:L693	R:R:W771	5.69	No	No	0	9	9
70	R:R:H694	R:R:L698	9	Yes	No	0	9	9
71	R:R:H694	R:R:V742	4.15	Yes	No	0	9	9
72	R:R:H694	R:R:Y753	13.07	Yes	Yes	4	9	9
73	R:R:H694	R:R:I772	7.95	Yes	No	4	9	8
74	R:R:H694	R:R:T781	5.48	Yes	No	0	9	7
75	R:R:H694	R:R:V782	5.54	Yes	No	0	9	9
76	R:R:F696	R:R:Y695	5.16	Yes	Yes	0	9	9
77	R:R:V699	R:R:Y695	8.83	No	Yes	2	7	9
78	R:R:W735	R:R:Y695	6.75	Yes	Yes	2	9	9
79	R:R:A739	R:R:Y695	4	No	Yes	0	9	9
80	R:R:V742	R:R:Y695	5.05	No	Yes	0	9	9
81	R:R:F701	R:R:L697	8.53	No	No	0	9	9
82	R:R:L698	R:R:P738	4.93	No	Yes	0	9	9
83	R:R:L698	R:R:Y785	3.52	No	No	0	9	9
84	R:R:V699	R:R:W735	12.26	No	Yes	2	7	9
85	R:R:P738	R:R:V699	5.3	Yes	No	0	9	7
86	R:R:F701	R:R:F786	10.72	No	No	0	9	9
87	R:R:F701	R:R:W838	10.02	No	Yes	0	9	9
88	R:R:G734	R:R:T702	5.46	No	No	0	9	9
89	R:R:P738	R:R:T702	5.25	Yes	No	0	9	9
90	R:R:T702	R:R:Y785	4.99	No	No	0	9	9
91	R:R:L706	R:R:W703	6.83	No	Yes	0	9	9
92	R:R:C731	R:R:W703	3.92	No	Yes	2	8	9
93	R:R:W703	R:R:W735	13.12	Yes	Yes	2	9	9
94	R:R:M704	R:R:W838	5.82	No	Yes	1	9	9
95	R:R:M704	R:R:Q863	5.44	No	Yes	1	9	9
96	R:R:G705	R:R:I789	3.53	No	No	0	8	7
97	R:R:F730	R:R:L706	8.53	Yes	No	0	8	9
98	R:R:E707	R:R:H710	3.69	No	Yes	3	9	9
99	R:R:E707	R:R:L833	5.3	No	No	0	9	9
100	R:R:F709	R:R:L713	7.31	No	Yes	0	7	5
101	R:R:F709	R:R:F730	4.29	No	Yes	0	7	8
102	R:R:H710	R:R:Y726	7.62	Yes	Yes	3	9	8
103	R:R:L713	R:R:Y712	3.52	Yes	No	0	5	9
104	R:R:V716	R:R:Y712	8.83	No	No	0	9	9
105	R:R:M796	R:R:Y712	3.59	No	No	0	9	9
106	R:R:L713	R:R:Y726	3.52	Yes	Yes	0	5	8
107	R:R:L715	R:R:Q803	3.99	No	No	0	8	9
108	R:R:I723	R:R:Y726	7.25	No	Yes	0	6	8
109	R:R:K725	R:R:R724	12.38	No	No	0	5	7
110	R:R:K725	R:R:L728	7.05	No	No	0	5	7
111	R:R:F730	R:R:Y726	14.44	Yes	Yes	0	8	8
112	R:R:G734	R:R:V733	3.68	No	No	0	9	4
113	R:R:V745	R:R:Y753	6.31	No	Yes	0	8	9
114	R:R:V745	R:R:V777	4.81	No	No	0	8	7
115	R:R:L746	R:R:Y753	4.69	No	Yes	4	8	9
116	R:R:P750	R:R:S749	3.56	No	No	0	6	6
117	R:R:N752	R:R:S749	5.96	No	No	0	8	6
118	R:R:N752	R:R:S774	4.47	No	No	0	8	7
119	R:R:I772	R:R:Y753	4.84	No	Yes	4	8	9
120	R:R:F769	R:R:G764	4.52	Yes	No	0	9	5
121	R:R:P766	R:R:T765	5.25	No	No	0	5	5
122	L:L:?1	R:R:T765	11.73	Yes	No	0	0	5
123	R:R:F769	R:R:P766	7.22	Yes	No	0	9	5
124	R:R:S774	R:R:V777	6.46	No	No	0	7	7
125	R:R:F778	R:R:Y779	7.22	Yes	No	9	9	9
126	R:R:F778	R:R:V782	7.87	Yes	No	0	9	9
127	R:R:F778	R:R:V783	3.93	Yes	No	0	9	9
128	R:R:F778	R:R:W845	5.01	Yes	No	9	9	8
129	R:R:W845	R:R:Y779	3.86	No	No	9	8	9
130	R:R:G784	R:R:V783	3.68	No	No	0	8	9
131	R:R:F786	R:R:F790	7.5	No	Yes	8	9	9
132	R:R:F786	R:R:F842	6.43	No	No	8	9	9
133	R:R:I789	R:R:N793	4.25	No	Yes	0	7	9
134	R:R:F790	R:R:V794	7.87	Yes	No	0	9	2
135	R:R:F790	R:R:G839	6.02	Yes	No	0	9	9
136	R:R:F790	R:R:F842	8.57	Yes	No	8	9	9
137	R:R:L834	R:R:N793	4.12	No	Yes	0	9	9
138	R:R:M796	R:R:V799	7.61	No	No	0	9	9
139	R:R:F797	R:R:L801	8.53	Yes	No	0	9	7
140	R:R:F797	R:R:L830	6.09	Yes	No	0	9	8
141	R:R:F797	R:R:T831	7.78	Yes	No	0	9	8
142	R:R:F797	R:R:L834	3.65	Yes	No	0	9	9
143	R:R:F797	R:R:I836	6.28	Yes	No	0	9	9
144	R:R:Q803	R:R:V799	4.3	No	No	0	9	9
145	R:R:R806	R:R:V802	5.23	No	No	0	9	7
146	R:R:K808	R:R:R817	9.9	No	No	0	9	7
147	R:R:Q816	R:R:R817	8.18	No	No	0	6	7
148	R:R:D823	R:R:T819	7.23	No	No	0	7	6
149	R:R:Q822	R:R:R825	5.84	No	No	0	7	9
150	R:R:D823	R:R:L824	5.43	No	No	0	7	5
151	R:R:A874	R:R:R825	5.53	No	No	0	5	9
152	R:R:A828	R:R:F870	5.55	No	Yes	0	5	9
153	R:R:F870	R:R:G829	6.02	Yes	No	0	9	9
154	R:R:G829	R:R:Y871	4.35	No	No	0	9	8
155	R:R:F832	R:R:T837	7.78	No	No	0	6	9
156	R:R:F832	R:R:F866	21.43	No	No	0	6	9
157	R:R:L833	R:R:Y871	12.89	No	No	0	9	8
158	R:R:N860	R:R:T837	5.85	No	No	0	9	9
159	R:R:F856	R:R:W838	4.01	Yes	Yes	1	9	9
160	R:R:N860	R:R:W838	24.86	No	Yes	1	9	9
161	R:R:Q863	R:R:W838	6.57	Yes	Yes	1	9	9
162	L:L:?1	R:R:W838	7.93	Yes	Yes	1	0	9
163	R:R:A841	R:R:F856	4.16	No	Yes	0	9	9
164	R:R:F843	R:R:F852	9.65	No	Yes	0	9	9
165	R:R:F852	R:R:N849	6.04	Yes	No	0	9	8
166	R:R:F856	R:R:N860	7.25	Yes	No	1	9	9
167	L:L:?1	R:R:F856	16.96	Yes	Yes	1	0	9
168	L:L:?1	R:R:T861	4.4	Yes	Yes	1	0	8
169	R:R:F865	R:R:L862	3.65	Yes	No	5	7	7
170	R:R:F866	R:R:L862	4.87	No	No	5	9	7
171	R:R:F865	R:R:F866	5.36	Yes	No	5	7	9
172	R:R:F865	R:R:I869	7.54	Yes	No	0	7	6
173	R:R:C872	R:R:F868	6.98	No	Yes	6	9	9
174	R:R:F870	R:R:I869	3.77	Yes	No	0	9	6
175	R:R:K875	R:R:N877	8.39	No	No	0	9	8
176	R:R:K875	R:R:V878	4.55	No	No	0	9	9
177	R:R:E876	R:R:N877	5.26	No	No	0	8	8
178	R:R:V878	R:R:W882	4.9	No	No	0	9	9
179	R:R:D768	R:R:Y680	3.45	No	No	0	4	8
180	R:R:I737	R:R:P738	3.39	No	Yes	0	4	9
181	R:R:G764	R:R:N763	3.39	No	No	0	5	5
182	R:R:C628	R:R:T861	3.38	No	Yes	0	9	8
183	R:R:C661	R:R:T638	3.38	No	No	0	9	9
184	R:R:F692	R:R:F696	3.22	No	Yes	0	7	9
185	R:R:F832	R:R:F859	3.22	No	No	0	6	8
186	R:R:F840	R:R:F852	3.22	No	Yes	0	9	9
187	R:R:F840	R:R:F856	3.22	No	Yes	0	9	9
188	R:R:A844	R:R:M853	3.22	No	No	0	9	8
189	R:R:C661	R:R:L639	3.17	No	No	0	9	9
190	R:R:T781	R:R:V741	3.17	No	No	0	7	7
191	R:R:A662	R:R:L639	3.15	No	No	0	4	9
192	R:R:A708	R:R:N793	3.13	No	Yes	0	9	9
193	R:R:I798	R:R:V794	3.07	No	No	0	6	2
194	R:R:I836	R:R:V794	3.07	No	No	0	9	2
195	R:R:I780	R:R:T781	3.04	No	No	0	9	7
196	R:R:F769	R:R:W771	3.01	Yes	No	0	9	9
197	R:R:L830	R:R:V800	2.98	No	No	0	8	9
198	R:R:I623	R:R:I858	2.94	No	No	0	9	9
199	R:R:A714	R:R:H710	2.93	No	Yes	0	9	9
200	R:R:M711	R:R:M796	2.89	No	No	0	9	9
201	R:R:I626	R:R:L630	2.85	No	No	0	9	5
202	R:R:K717	R:R:L713	2.82	No	Yes	0	9	5
203	R:R:K808	R:R:L804	2.82	No	No	0	9	9
204	R:R:G835	R:R:W838	2.81	No	Yes	0	9	9
205	R:R:C787	R:R:F842	2.79	No	No	0	6	9
206	R:R:L665	R:R:L669	2.77	No	No	0	8	8
207	R:R:I867	R:R:Q863	2.74	No	Yes	0	9	9
208	R:R:K810	R:R:Q816	2.71	No	No	0	7	6
209	R:R:K811	R:R:Q816	2.71	No	No	0	9	6
210	R:R:A619	R:R:Y854	2.67	No	Yes	0	8	9
211	R:R:D767	R:R:D768	2.66	No	No	0	8	4
212	R:R:F868	R:R:V637	2.62	Yes	No	0	9	4
213	R:R:A663	R:R:W735	2.59	No	Yes	0	9	9
214	R:R:V850	R:R:Y854	2.52	No	Yes	0	5	9
215	R:R:I658	R:R:R649	2.51	No	No	0	9	9
216	R:R:F859	R:R:I858	2.51	No	No	0	8	9
217	R:R:F634	R:R:L630	2.44	No	No	0	9	5
218	R:R:F859	R:R:L855	2.44	No	No	0	8	9
219	R:R:F719	R:R:N720	2.42	No	No	0	9	9
220	R:R:N775	R:R:Y779	2.33	No	No	0	6	9
221	R:R:Q616	R:R:Y854	2.25	No	Yes	0	7	9
222	R:R:F870	R:R:R825	2.14	Yes	No	0	9	9
223	R:R:G736	R:R:P738	2.03	No	Yes	0	9	9
224	R:R:R879	R:R:W882	2	No	No	0	9	9
225	R:R:A815	R:R:G814	1.95	No	No	0	4	8
226	R:R:G629	R:R:S632	1.86	No	No	0	9	9
227	R:R:G754	R:R:I687	1.76	No	No	0	9	9
228	R:R:G754	R:R:N773	1.7	No	No	0	9	5
229	R:R:A857	R:R:T861	1.68	No	Yes	0	7	8
230	R:R:S636	R:R:V637	1.62	No	No	0	9	4
231	R:R:S743	R:R:V742	1.62	No	No	0	7	9
232	R:R:S774	R:R:V776	1.62	No	No	0	7	5
233	R:R:D751	R:R:P750	1.61	No	No	0	4	6
234	R:R:T641	R:R:V640	1.59	No	No	0	9	8
235	R:R:C686	R:R:L679	1.59	No	Yes	7	9	8
236	R:R:C770	R:R:L679	1.59	No	Yes	7	9	8
237	R:R:T621	R:R:T765	1.57	No	No	0	9	5
238	R:R:I633	R:R:S632	1.55	No	No	0	9	9
239	R:R:I748	R:R:S749	1.55	No	No	0	5	6
240	R:R:I744	R:R:V740	1.54	No	No	0	8	5
241	R:R:I798	R:R:V802	1.54	No	No	0	6	7
242	R:R:L672	R:R:S675	1.5	No	No	0	9	7
243	R:R:G684	R:R:R683	1.5	No	No	0	6	5
244	R:R:K717	R:R:T721	1.5	No	No	0	9	7
245	R:R:N849	R:R:V848	1.48	No	No	0	8	7
246	R:R:I744	R:R:I748	1.47	No	No	0	8	5
247	R:R:D823	R:R:S826	1.47	No	No	0	7	9
248	R:R:I723	R:R:K729	1.45	No	No	0	6	9
249	R:R:Q822	R:R:S820	1.44	No	No	0	7	6
250	R:R:I677	R:R:L673	1.43	No	No	0	8	8
251	R:R:I732	R:R:L728	1.43	No	No	0	5	7
252	R:R:I827	R:R:L801	1.43	No	No	0	7	7
253	R:R:I827	R:R:L804	1.43	No	No	0	7	9
254	R:R:L620	R:R:M617	1.41	Yes	No	1	9	4
255	L:L:?1	R:R:M617	1.41	Yes	No	1	0	4
256	R:R:L620	R:R:M853	1.41	Yes	No	0	9	8
257	R:R:G846	R:R:W845	1.41	No	No	0	8	8
258	R:R:D768	R:R:I755	1.4	No	No	0	4	6
259	R:R:A873	R:R:F868	1.39	No	Yes	0	8	9
260	R:R:L792	R:R:N793	1.37	No	Yes	0	6	9
261	R:R:F852	R:R:T851	1.3	Yes	No	0	9	5
262	R:R:K729	R:R:R724	1.24	No	No	0	9	7
263	R:R:F790	R:R:L791	1.22	Yes	No	0	9	6
264	R:R:R724	R:R:Y722	1.03	No	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L620	2.6175	4	1	9
2	R:R:Y642	5.802	5	0	9
3	R:R:L679	3.3275	4	7	8
4	R:R:H694	7.53167	6	4	9
5	R:R:Y695	5.958	5	2	9
6	R:R:F696	7.945	4	0	9
7	R:R:W703	9.8	4	2	9
8	R:R:H710	5.50833	6	3	9
9	R:R:L713	4.2925	4	0	5
10	R:R:Y726	10.736	5	3	8
11	R:R:F730	7.7575	4	0	8
12	R:R:W735	7.82	5	2	9
13	R:R:P738	4.18	5	0	9
14	R:R:Y753	7.37833	6	4	9
15	R:R:F769	6.674	5	0	9
16	R:R:F778	6.0075	4	9	9
17	R:R:F790	6.236	5	8	9
18	R:R:N793	3.2175	4	0	9
19	R:R:F797	6.466	5	0	9
20	R:R:W838	8.86	7	1	9
21	R:R:F852	5.0525	4	0	9
22	R:R:Y854	2.74	4	0	9
23	R:R:F856	7.12	5	1	9
24	R:R:T861	3.562	5	1	8
25	R:R:Q863	5.0175	4	1	9
26	R:R:F865	6.8175	4	5	7
27	R:R:F868	7.14	5	6	9
28	R:R:F870	4.37	4	0	9
29	L:L:?1	9.40625	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F634	R:R:F865	22.5431	10.72	No	Yes	0	9	7
2	R:R:F865	R:R:F866	99.0356	5.36	Yes	No	5	7	9
3	R:R:F832	R:R:F866	99.8469	21.43	No	No	0	6	9
4	R:R:F832	R:R:T837	100	7.78	No	No	0	6	9
5	R:R:N860	R:R:T837	100	5.85	No	No	0	9	9
6	R:R:N860	R:R:W838	64.777	24.86	No	Yes	1	9	9
7	L:L:?1	R:R:W838	39.453	7.93	Yes	Yes	1	0	9
8	L:L:?1	R:R:L620	13.2411	4.13	Yes	Yes	1	0	9
9	R:R:F856	R:R:N860	35.2077	7.25	Yes	No	1	9	9
10	L:L:?1	R:R:F856	31.0542	16.96	Yes	Yes	1	0	9
11	L:L:?1	R:R:T861	13.1748	4.4	Yes	Yes	1	0	8
12	R:R:F701	R:R:W838	41.4838	10.02	No	Yes	0	9	9
13	R:R:F701	R:R:L697	12.8482	8.53	No	No	0	9	9
14	R:R:L667	R:R:L697	11.7308	4.15	No	No	0	9	9
15	R:R:L667	R:R:N668	10.6031	4.12	No	No	0	9	9
16	R:R:F634	R:R:F868	17.8896	18.22	No	Yes	0	9	9
17	R:R:I648	R:R:Y642	10.1235	9.67	No	Yes	0	8	9
18	R:R:L657	R:R:Y642	18.655	4.69	No	Yes	0	9	9
19	R:R:L657	R:R:Y871	19.7826	5.86	No	No	0	9	8
20	R:R:G829	R:R:Y871	87.8763	4.35	No	No	0	9	8
21	R:R:F870	R:R:G829	88.1978	6.02	Yes	No	0	9	9
22	R:R:F870	R:R:I869	89.9633	3.77	Yes	No	0	9	6
23	R:R:F865	R:R:I869	90.249	7.54	Yes	No	0	7	6
24	R:R:S654	R:R:Y642	16.369	3.82	No	Yes	0	9	9
25	R:R:K875	R:R:Y642	13.8228	3.58	No	Yes	0	9	9
26	R:R:K875	R:R:V878	10.695	4.55	No	No	0	9	9
27	R:R:V878	R:R:W882	10.3684	4.9	No	No	0	9	9
28	R:R:D651	R:R:S654	16.119	8.83	No	No	0	9	9
29	R:R:L833	R:R:Y871	80.6715	12.89	No	No	0	9	8
30	R:R:E707	R:R:L833	80.1306	5.3	No	No	0	9	9
31	R:R:E707	R:R:H710	20.9358	3.69	No	Yes	3	9	9
32	R:R:H710	R:R:P653	17.2824	9.15	Yes	No	0	9	9
33	R:R:H710	R:R:Y726	25.6149	7.62	Yes	Yes	3	9	8
34	R:R:E707	R:R:I656	58.6488	6.83	No	No	3	9	9
35	R:R:F730	R:R:I656	65.2975	3.77	Yes	No	0	8	9
36	R:R:F730	R:R:L706	79.3295	8.53	Yes	No	0	8	9
37	R:R:L706	R:R:W703	78.2121	6.83	No	Yes	0	9	9
38	R:R:W703	R:R:W735	74.528	13.12	Yes	Yes	2	9	9
39	R:R:W735	R:R:Y695	58.3172	6.75	Yes	Yes	2	9	9
40	L:L:?1	R:R:F671	37.9631	16.96	Yes	No	0	0	9
41	R:R:F671	R:R:F769	36.3813	4.29	No	Yes	0	9	9
42	R:R:D674	R:R:F769	28.0845	14.33	No	Yes	0	9	9
43	R:R:C770	R:R:D674	24.4719	6.22	No	No	0	9	9
44	R:R:C770	R:R:L679	11.3226	1.59	No	Yes	7	9	8
45	R:R:C686	R:R:C770	11.3226	7.28	No	No	7	9	9
46	R:R:D751	R:R:P750	10.098	1.61	No	No	0	4	6
47	R:R:P750	R:R:S749	11.7461	3.56	No	No	0	6	6
48	R:R:N752	R:R:S749	18.2366	5.96	No	No	0	8	6
49	R:R:N752	R:R:S774	19.8337	4.47	No	No	0	8	7
50	R:R:S774	R:R:V777	22.9972	6.46	No	No	0	7	7
51	R:R:V745	R:R:V777	24.5637	4.81	No	No	0	8	7
52	R:R:V745	R:R:Y753	26.1098	6.31	No	Yes	0	8	9
53	R:R:H694	R:R:Y753	32.0696	13.07	Yes	Yes	4	9	9
54	R:R:H694	R:R:V742	48.7039	4.15	Yes	No	0	9	9
55	R:R:V742	R:R:Y695	51.2654	5.05	No	Yes	0	9	9
56	R:R:V699	R:R:W735	14.3841	12.26	No	Yes	2	7	9
57	R:R:P738	R:R:V699	13.4963	5.3	Yes	No	0	9	7
58	R:R:H694	R:R:V782	13.1289	5.54	Yes	No	0	9	9
59	R:R:F701	R:R:F786	31.0746	10.72	No	No	0	9	9
60	R:R:F797	R:R:I836	20.2266	6.28	Yes	No	0	9	9
61	R:R:I836	R:R:V794	21.2624	3.07	No	No	0	9	2
62	R:R:F790	R:R:V794	25.3036	7.87	Yes	No	0	9	2
63	R:R:F786	R:R:F790	27.9773	7.5	No	Yes	8	9	9
64	R:R:L713	R:R:Y726	13.8739	3.52	Yes	Yes	0	5	8
65	R:R:L713	R:R:Y712	11.792	3.52	Yes	No	0	5	9
66	R:R:F778	R:R:V782	11.6338	7.87	Yes	No	0	9	9
67	R:R:D651	R:R:P653	15.869	8.05	No	No	0	9	9
68	R:R:F730	R:R:Y726	13.4299	14.44	Yes	Yes	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L620	R:R:Y854	3.52	1	Yes	Yes	9	9	1	2
L:L:?1	R:R:L620	4.13	1	Yes	Yes	0	9	0	1
R:R:T624	R:R:T861	4.71	1	No	Yes	9	8	1	1
L:L:?1	R:R:T624	11.73	1	Yes	No	0	9	0	1
R:R:G627	R:R:T861	3.64	0	No	Yes	9	8	2	1
R:R:F671	R:R:F769	4.29	0	No	Yes	9	9	1	2
L:L:?1	R:R:F671	16.96	1	Yes	No	0	9	0	1
R:R:F701	R:R:W838	10.02	0	No	Yes	9	9	2	1
R:R:M704	R:R:W838	5.82	1	No	Yes	9	9	2	1
R:R:M704	R:R:Q863	5.44	1	No	Yes	9	9	2	2
R:R:P766	R:R:T765	5.25	0	No	No	5	5	2	1
L:L:?1	R:R:T765	11.73	1	Yes	No	0	5	0	1
R:R:F769	R:R:P766	7.22	0	Yes	No	9	5	2	2
R:R:F856	R:R:W838	4.01	1	Yes	Yes	9	9	1	1
R:R:N860	R:R:W838	24.86	1	No	Yes	9	9	2	1
R:R:Q863	R:R:W838	6.57	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:W838	7.93	1	Yes	Yes	0	9	0	1
R:R:A841	R:R:F856	4.16	0	No	Yes	9	9	2	1
R:R:F856	R:R:N860	7.25	1	Yes	No	9	9	1	2
L:L:?1	R:R:F856	16.96	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:T861	4.4	1	Yes	Yes	0	8	0	1
R:R:C628	R:R:T861	3.38	0	No	Yes	9	8	2	1
R:R:F840	R:R:F856	3.22	0	No	Yes	9	9	2	1
R:R:G835	R:R:W838	2.81	0	No	Yes	9	9	2	1
R:R:A857	R:R:T861	1.68	0	No	Yes	7	8	2	1
R:R:T621	R:R:T765	1.57	0	No	No	9	5	2	1
R:R:L620	R:R:M617	1.41	1	Yes	No	9	4	1	1
L:L:?1	R:R:M617	1.41	1	Yes	No	0	4	0	1
R:R:L620	R:R:M853	1.41	1	Yes	No	9	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XKF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	244
Number of Links	264
Number of Hubs	29
Number of Links mediated by Hubs	126
Number of Communities	9
Number of Nodes involved in Communities	41
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	37151
Length Of Smallest Path	3
Average Path Length	17.1925
Length of Longest Path	45
Minimum Path Strength	1.24
Average Path Strength	7.53013
Maximum Path Strength	17.645
Minimum Path Correlation	0.7
Average Path Correlation	0.936575
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	50.0963
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.0952
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • spermatid development • spermatid differentiation • sexual reproduction • cellular developmental process • spermatogenesis • reproductive process • multicellular organismal reproductive process • cell development • cellular process involved in reproduction in multicellular organism • developmental process involved in reproduction • gamete generation • male gamete generation • cell differentiation • anatomical structure development • germ cell development • cell surface receptor signaling pathway • cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AND
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	AND
Name	Prasterone
Synonyms	Dehydroepiandrosterone
Identifier
Formula	C19 H28 O2
Molecular Weight	288.424
SMILES
PubChem	5881
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	6
Total Bonds	52
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8CJ12
Sequence	>7XKF_nogp_Chain_R Q M M A L T F I T Y I G C G L S S I F L S V T L V T Y I A F E K I R R D Y P S K I L I Q L C A A L L L L N L I F L L D S W I A L Y N T R G F C I A V A V F L H Y F L L V S F T W M G L E A F H M Y L A L V K V F N T Y I R K Y I L K F C I V G W G I P A V V V S I V L T I S P D N Y G I G N G T P D D F C W I N S N V V F Y I T V V G Y F C V I F L L N V S M F I V V L V Q L C R I K K K K Q L G A Q R K T S I Q D L R S I A G L T F L L G I T W G F A F F A W G V N V T F M Y L F A I F N T L Q G F F I F I F Y C A A K E N V R K Q W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WUI	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	IP15	-	chim(NtGi1-Gs)/β1/γ2	3.1	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7WUI (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	IP15	-		3.1	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7WUQ	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-	Gs/β1/γ2	2.9	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7WUQ (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-		2.9	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7XKD	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-	Gs/β1/γ2	2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKD (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-		2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKE	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKE (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-		2.9	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKF	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-	Gs/β1/γ2	2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKF (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-		2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7YP7	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-	Gs/β1/γ2	3.1	2022-08-24	doi.org/10.1038/s41589-022-01084-6
	7YP7 (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-		3.1	2022-08-24	doi.org/10.1038/s41589-022-01084-6
	8YKD	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-	chim(NtGi1-Gs)/β1/γ2	2.9	2025-08-13	doi.org/10.1038/s41589-025-01896-2
	8YKD (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-		2.9	2025-08-13	doi.org/10.1038/s41589-025-01896-2

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