psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L620	5.51	Yes	No	0	0	9
2	L:L:?1	R:R:N763	4.1	Yes	No	0	0	5
3	L:L:?1	R:R:T765	5.87	Yes	No	0	0	5
4	L:L:?1	R:R:M853	4.22	Yes	No	0	0	8
5	L:L:?1	R:R:F856	7.27	Yes	No	0	0	9
6	R:R:F671	R:R:T624	3.89	No	No	0	9	9
7	R:R:S675	R:R:Y625	11.45	No	No	0	7	8
8	R:R:W676	R:R:Y625	11.58	No	No	0	9	8
9	R:R:G627	R:R:T861	3.64	No	No	0	9	8
10	R:R:C628	R:R:L672	4.76	No	No	0	9	9
11	R:R:G629	R:R:S632	3.71	No	No	0	9	9
12	R:R:F634	R:R:L630	8.53	Yes	No	5	9	5
13	R:R:F865	R:R:L630	6.09	Yes	No	5	7	5
14	R:R:N668	R:R:S631	10.43	No	No	0	9	9
15	R:R:G864	R:R:S631	3.71	No	No	0	9	9
16	R:R:N668	R:R:S632	4.47	No	No	0	9	9
17	R:R:L669	R:R:S632	6.01	No	No	0	8	9
18	R:R:F634	R:R:I633	6.28	Yes	No	0	9	9
19	R:R:F634	R:R:F865	10.72	Yes	Yes	5	9	7
20	R:R:F634	R:R:F868	15	Yes	Yes	0	9	9
21	R:R:L635	R:R:L665	4.15	No	No	0	9	8
22	R:R:G864	R:R:L635	5.13	No	No	0	9	9
23	R:R:C661	R:R:T638	5.07	No	No	0	9	9
24	R:R:F868	R:R:T638	5.19	Yes	No	0	9	9
25	R:R:A662	R:R:L639	4.73	No	No	0	4	9
26	R:R:C872	R:R:T641	5.07	No	Yes	0	9	9
27	R:R:T641	R:R:W882	9.7	Yes	No	0	9	9
28	R:R:S654	R:R:Y642	5.09	No	Yes	0	9	9
29	R:R:L657	R:R:Y642	4.69	No	Yes	0	9	9
30	R:R:I658	R:R:Y642	3.63	No	Yes	0	9	9
31	R:R:K875	R:R:Y642	3.58	No	Yes	0	9	9
32	R:R:F645	R:R:Q881	14.05	No	No	0	9	9
33	R:R:E646	R:R:R649	16.28	No	No	0	6	9
34	R:R:K647	R:R:Q881	6.78	No	No	0	9	9
35	R:R:I648	R:R:N877	5.66	No	No	3	8	8
36	R:R:I648	R:R:V878	7.68	No	Yes	3	8	9
37	R:R:I648	R:R:Q881	5.49	No	No	0	8	9
38	R:R:D651	R:R:P653	8.05	No	No	0	9	9
39	R:R:D651	R:R:S654	7.36	No	No	0	9	9
40	R:R:Y652	R:R:Y726	21.84	No	Yes	0	8	8
41	R:R:I727	R:R:Y652	4.84	No	No	0	8	8
42	R:R:I727	R:R:K655	10.18	No	No	0	8	9
43	R:R:E707	R:R:I656	6.83	No	No	0	9	9
44	R:R:H710	R:R:I656	5.3	No	No	0	9	9
45	R:R:F730	R:R:I656	5.02	Yes	No	0	8	9
46	R:R:L657	R:R:Y871	5.86	No	No	0	9	8
47	R:R:I658	R:R:Q659	4.12	No	Yes	0	9	7
48	R:R:Q659	R:R:W703	15.33	Yes	Yes	1	7	9
49	R:R:C731	R:R:Q659	6.1	No	Yes	1	8	7
50	R:R:Q659	R:R:W735	5.48	Yes	Yes	1	7	9
51	R:R:L660	R:R:L664	5.54	No	No	0	9	9
52	R:R:E707	R:R:L660	14.58	No	No	0	9	9
53	R:R:L664	R:R:S700	4.5	No	No	0	9	7
54	R:R:L664	R:R:Q863	6.65	No	Yes	0	9	9
55	R:R:L665	R:R:L669	4.15	No	No	0	8	8
56	R:R:F696	R:R:L666	13.4	No	No	0	9	5
57	R:R:I670	R:R:L693	5.71	No	No	0	6	9
58	R:R:F696	R:R:I670	7.54	No	No	0	9	6
59	R:R:F671	R:R:L693	3.65	No	No	0	9	9
60	R:R:D674	R:R:V689	8.76	No	No	0	9	8
61	R:R:D674	R:R:F769	19.11	No	No	0	9	9
62	R:R:C770	R:R:D674	7.78	No	No	0	9	9
63	R:R:I677	R:R:L679	5.71	No	Yes	0	8	8
64	R:R:I755	R:R:Y680	7.25	No	No	0	6	8
65	R:R:D768	R:R:Y680	5.75	No	No	0	4	8
66	R:R:F685	R:R:T682	10.38	No	Yes	0	8	4
67	R:R:I687	R:R:R683	6.26	No	No	0	9	5
68	R:R:D751	R:R:R683	5.96	No	No	0	4	5
69	R:R:C686	R:R:I755	4.91	No	No	0	9	6
70	R:R:C686	R:R:C770	7.28	No	No	6	9	9
71	R:R:A690	R:R:Y753	4	No	Yes	0	9	9
72	R:R:L746	R:R:V691	8.94	No	No	0	8	6
73	R:R:V691	R:R:Y753	11.36	No	Yes	0	6	9
74	R:R:L693	R:R:W771	4.56	No	Yes	0	9	9
75	R:R:H694	R:R:L698	9	Yes	No	0	9	9
76	R:R:H694	R:R:Y753	14.16	Yes	Yes	7	9	9
77	R:R:H694	R:R:I772	5.3	Yes	No	7	9	8
78	R:R:H694	R:R:T781	5.48	Yes	No	0	9	7
79	R:R:F696	R:R:Y695	5.16	No	Yes	0	9	9
80	R:R:V699	R:R:Y695	8.83	No	Yes	1	7	9
81	R:R:W735	R:R:Y695	5.79	Yes	Yes	1	9	9
82	R:R:V742	R:R:Y695	3.79	No	Yes	0	9	9
83	R:R:F701	R:R:L697	10.96	Yes	No	0	9	9
84	R:R:L698	R:R:P738	4.93	No	Yes	0	9	9
85	R:R:L698	R:R:V741	4.47	No	No	0	9	7
86	R:R:V699	R:R:W735	11.03	No	Yes	1	7	9
87	R:R:P738	R:R:V699	5.3	Yes	No	0	9	7
88	R:R:F701	R:R:M704	3.73	Yes	Yes	4	9	9
89	R:R:F701	R:R:F786	10.72	Yes	No	0	9	9
90	R:R:F701	R:R:W838	12.03	Yes	Yes	4	9	9
91	R:R:G734	R:R:T702	3.64	No	Yes	0	9	9
92	R:R:P738	R:R:T702	5.25	Yes	Yes	0	9	9
93	R:R:T702	R:R:Y785	11.24	Yes	No	0	9	9
94	R:R:L706	R:R:W703	6.83	No	Yes	0	9	9
95	R:R:C731	R:R:W703	3.92	No	Yes	1	8	9
96	R:R:W703	R:R:W735	14.06	Yes	Yes	1	9	9
97	R:R:M704	R:R:W838	5.82	Yes	Yes	4	9	9
98	R:R:M704	R:R:Q863	6.8	Yes	Yes	4	9	9
99	R:R:F730	R:R:L706	6.09	Yes	No	0	8	9
100	R:R:E707	R:R:L833	11.93	No	No	0	9	9
101	R:R:A708	R:R:N793	4.69	No	Yes	0	9	9
102	R:R:F709	R:R:L713	8.53	No	Yes	0	7	5
103	R:R:F709	R:R:F730	4.29	No	Yes	0	7	8
104	R:R:H710	R:R:Y726	9.8	No	Yes	0	9	8
105	R:R:L834	R:R:M711	4.24	Yes	No	0	9	9
106	R:R:V716	R:R:Y712	11.36	No	No	0	9	9
107	R:R:M796	R:R:Y712	5.99	No	No	0	9	9
108	R:R:K717	R:R:L713	4.23	No	Yes	0	9	5
109	R:R:L713	R:R:Y726	5.86	Yes	Yes	0	5	8
110	R:R:K717	R:R:T721	4.5	No	No	0	9	7
111	R:R:I723	R:R:Y726	4.84	No	Yes	0	6	8
112	R:R:K725	R:R:R724	3.71	No	No	0	5	7
113	R:R:K725	R:R:L728	11.28	No	No	0	5	7
114	R:R:F730	R:R:Y726	17.54	Yes	Yes	0	8	8
115	R:R:C731	R:R:W735	5.22	No	Yes	1	8	9
116	R:R:I737	R:R:Y785	3.63	No	No	0	4	9
117	R:R:V745	R:R:Y753	6.31	No	Yes	0	8	9
118	R:R:N752	R:R:S749	8.94	No	No	0	8	6
119	R:R:I772	R:R:Y753	4.84	No	Yes	7	8	9
120	R:R:N763	R:R:W771	13.56	No	Yes	0	5	9
121	R:R:F769	R:R:G764	7.53	No	No	0	9	5
122	R:R:P766	R:R:T765	8.74	No	No	0	5	5
123	R:R:D768	R:R:P766	8.05	No	No	0	4	5
124	R:R:F769	R:R:P766	4.33	No	No	0	9	5
125	R:R:D767	R:R:D768	6.65	No	No	0	8	4
126	R:R:I772	R:R:W771	11.74	No	Yes	0	8	9
127	R:R:F778	R:R:W771	6.01	Yes	Yes	0	9	9
128	R:R:S774	R:R:V777	6.46	No	No	0	7	7
129	R:R:F778	R:R:Y779	4.13	Yes	No	0	9	9
130	R:R:F778	R:R:V782	9.18	Yes	No	0	9	9
131	R:R:F778	R:R:V783	3.93	Yes	No	0	9	9
132	R:R:C787	R:R:G784	3.92	No	No	0	6	8
133	R:R:I789	R:R:Y785	3.63	No	No	0	7	9
134	R:R:F786	R:R:F790	7.5	No	No	0	9	9
135	R:R:F790	R:R:G839	6.02	No	No	0	9	9
136	R:R:F790	R:R:F842	5.36	No	No	0	9	9
137	R:R:L834	R:R:N793	8.24	Yes	Yes	0	9	9
138	R:R:F797	R:R:L801	7.31	Yes	No	0	9	7
139	R:R:F797	R:R:L830	6.09	Yes	No	2	9	8
140	R:R:F797	R:R:T831	7.78	Yes	No	2	9	8
141	R:R:F797	R:R:L834	3.65	Yes	Yes	2	9	9
142	R:R:F797	R:R:I836	6.28	Yes	No	2	9	9
143	R:R:L830	R:R:V800	4.47	No	No	0	8	9
144	R:R:I827	R:R:L801	5.71	No	No	0	7	7
145	R:R:R806	R:R:V802	7.85	No	No	0	9	7
146	R:R:I821	R:R:L824	5.71	No	No	0	6	5
147	R:R:D823	R:R:L824	6.79	No	No	0	7	5
148	R:R:F870	R:R:R825	4.28	Yes	No	0	9	9
149	R:R:A874	R:R:R825	5.53	No	No	0	5	9
150	R:R:A828	R:R:F870	4.16	No	Yes	0	5	9
151	R:R:F870	R:R:G829	6.02	Yes	No	0	9	9
152	R:R:L830	R:R:L834	4.15	No	Yes	2	8	9
153	R:R:I836	R:R:T831	4.56	No	No	2	9	8
154	R:R:F832	R:R:T837	7.78	No	No	0	6	9
155	R:R:F832	R:R:F866	19.29	No	No	0	6	9
156	R:R:L833	R:R:Y871	14.07	No	No	0	9	8
157	R:R:F859	R:R:T837	7.78	Yes	No	0	8	9
158	R:R:N860	R:R:W838	18.08	No	Yes	0	9	9
159	R:R:Q863	R:R:W838	8.76	Yes	Yes	4	9	9
160	R:R:F840	R:R:L855	10.96	No	No	8	9	9
161	R:R:F840	R:R:F859	4.29	No	Yes	8	9	8
162	R:R:A841	R:R:F856	5.55	No	No	0	9	9
163	R:R:F843	R:R:F852	4.29	No	No	0	9	9
164	R:R:N849	R:R:V848	4.43	No	No	0	8	7
165	R:R:F852	R:R:N849	8.46	No	No	0	9	8
166	R:R:F852	R:R:T851	3.89	No	No	0	9	5
167	R:R:F859	R:R:L855	7.31	Yes	No	8	8	9
168	R:R:F856	R:R:N860	16.92	No	No	0	9	9
169	R:R:F859	R:R:I858	3.77	Yes	No	0	8	9
170	R:R:F866	R:R:L862	6.09	No	No	0	9	7
171	R:R:F865	R:R:F866	6.43	Yes	No	0	7	9
172	R:R:F865	R:R:I869	8.79	Yes	No	0	7	6
173	R:R:F868	R:R:I869	5.02	Yes	No	0	9	6
174	R:R:C872	R:R:F868	6.98	No	Yes	0	9	9
175	R:R:F870	R:R:I869	3.77	Yes	No	0	9	6
176	R:R:K875	R:R:N877	8.39	No	No	3	9	8
177	R:R:K875	R:R:V878	6.07	No	Yes	3	9	9
178	R:R:E876	R:R:R879	8.14	No	No	0	8	9
179	R:R:N877	R:R:V878	4.43	No	Yes	3	8	9
180	R:R:V878	R:R:W882	3.68	Yes	No	0	9	9
181	R:R:P750	R:R:S749	3.56	No	No	0	6	6
182	R:R:G705	R:R:I789	3.53	No	No	0	8	7
183	R:R:L672	R:R:Y625	3.52	No	No	0	9	8
184	R:R:L713	R:R:Y712	3.52	Yes	No	0	5	9
185	R:R:Q822	R:R:R825	3.5	No	No	0	7	9
186	R:R:G627	R:R:L862	3.42	No	No	0	9	7
187	R:R:G705	R:R:N793	3.39	No	Yes	0	8	9
188	R:R:G754	R:R:N773	3.39	No	No	0	9	5
189	R:R:C628	R:R:T861	3.38	No	No	0	9	8
190	L:L:?1	R:R:P762	3.27	Yes	No	0	0	3
191	R:R:S774	R:R:V776	3.23	No	No	0	7	5
192	R:R:V745	R:R:V777	3.21	No	No	0	8	7
193	R:R:C661	R:R:L635	3.17	No	No	0	9	9
194	R:R:C686	R:R:L679	3.17	No	Yes	6	9	8
195	R:R:C770	R:R:L679	3.17	No	Yes	6	9	8
196	R:R:A714	R:R:L715	3.15	No	No	0	9	8
197	R:R:M796	R:R:S795	3.07	No	No	0	9	4
198	R:R:N681	R:R:T682	2.92	No	Yes	0	3	4
199	R:R:Q803	R:R:V799	2.87	No	No	0	9	9
200	R:R:I677	R:R:L673	2.85	No	No	0	8	8
201	R:R:I732	R:R:L728	2.85	No	No	0	5	7
202	R:R:C787	R:R:F842	2.79	No	No	0	6	9
203	R:R:L667	R:R:L697	2.77	No	No	0	9	9
204	R:R:I867	R:R:Q863	2.74	No	Yes	0	9	9
205	R:R:P762	R:R:W845	2.7	No	No	0	3	8
206	R:R:A739	R:R:Y695	2.67	No	Yes	0	9	9
207	R:R:A663	R:R:W735	2.59	No	Yes	0	9	9
208	R:R:V850	R:R:Y854	2.52	No	Yes	0	5	9
209	R:R:I623	R:R:Y854	2.42	No	Yes	0	9	9
210	R:R:I687	R:R:Y753	2.42	No	Yes	0	9	9
211	R:R:M853	R:R:Y854	2.39	No	Yes	0	8	9
212	R:R:Q803	R:R:R806	2.34	No	No	0	9	9
213	R:R:G736	R:R:P738	2.03	No	Yes	0	9	9
214	R:R:Y652	R:R:Y722	1.99	No	No	0	8	6
215	R:R:G846	R:R:V848	1.84	No	No	0	8	7
216	R:R:G684	R:R:T682	1.82	No	Yes	0	6	4
217	R:R:G627	R:R:I626	1.76	No	No	0	9	9
218	R:R:G754	R:R:I687	1.76	No	No	0	9	9
219	R:R:G835	R:R:M704	1.75	No	Yes	0	9	9
220	R:R:G814	R:R:L813	1.71	No	No	0	8	8
221	R:R:C805	R:R:K809	1.62	No	No	0	5	6
222	R:R:A844	R:R:M853	1.61	No	No	0	9	8
223	R:R:V716	R:R:V799	1.6	No	No	0	9	9
224	R:R:T641	R:R:V637	1.59	Yes	No	0	9	4
225	R:R:C661	R:R:L639	1.59	No	No	0	9	9
226	R:R:T641	R:R:V640	1.59	Yes	No	0	9	8
227	R:R:T702	R:R:V733	1.59	Yes	No	0	9	4
228	L:L:?1	R:R:A857	1.57	Yes	No	0	0	7
229	R:R:T621	R:R:T765	1.57	No	No	0	9	5
230	R:R:I633	R:R:S636	1.55	No	No	0	9	9
231	R:R:I744	R:R:V740	1.54	No	No	0	8	5
232	R:R:I798	R:R:V794	1.54	No	No	0	6	2
233	R:R:I798	R:R:V802	1.54	No	No	0	6	7
234	R:R:L715	R:R:V800	1.49	No	No	0	8	9
235	R:R:N752	R:R:S774	1.49	No	No	0	8	7
236	R:R:L792	R:R:V788	1.49	No	No	0	6	5
237	R:R:L679	R:R:T682	1.47	Yes	Yes	0	8	4
238	R:R:I723	R:R:K729	1.45	No	No	0	6	9
239	R:R:Q822	R:R:S826	1.44	No	No	0	7	9
240	R:R:I827	R:R:L804	1.43	No	No	0	7	9
241	R:R:I748	R:R:N752	1.42	No	No	0	5	8
242	R:R:K717	R:R:N720	1.4	No	No	0	9	9
243	R:R:A644	R:R:F645	1.39	No	No	0	7	9
244	R:R:A873	R:R:F868	1.39	No	Yes	0	8	9
245	R:R:L792	R:R:N793	1.37	No	Yes	0	6	9
246	R:R:A619	R:R:Y854	1.33	No	Yes	0	8	9
247	R:R:L813	R:R:Q812	1.33	No	No	0	8	8
248	R:R:R649	R:R:S654	1.32	No	No	0	9	9
249	R:R:F692	R:R:I670	1.26	No	No	0	7	6
250	R:R:K647	R:R:R650	1.24	No	No	0	9	8
251	R:R:I780	R:R:Y779	1.21	No	No	0	9	9
252	R:R:F840	R:R:F843	1.07	No	No	0	9	9
253	R:R:R883	R:R:W882	1	No	No	0	9	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	4.54429	7	0	0
2	R:R:F634	10.1325	4	5	9
3	R:R:T641	4.4875	4	0	9
4	R:R:Y642	4.2475	4	0	9
5	R:R:Q659	7.7575	4	1	7
6	R:R:L679	3.38	4	6	8
7	R:R:T682	4.1475	4	0	4
8	R:R:H694	8.485	4	7	9
9	R:R:Y695	5.248	5	1	9
10	R:R:F701	9.36	4	4	9
11	R:R:T702	5.43	4	0	9
12	R:R:W703	10.035	4	1	9
13	R:R:M704	4.525	4	4	9
14	R:R:L713	5.535	4	0	5
15	R:R:Y726	11.976	5	0	8
16	R:R:F730	8.235	4	0	8
17	R:R:W735	7.36167	6	1	9
18	R:R:P738	4.3775	4	0	9
19	R:R:Y753	7.18167	6	7	9
20	R:R:W771	8.9675	4	0	9
21	R:R:F778	5.8125	4	0	9
22	R:R:N793	4.4225	4	0	9
23	R:R:F797	6.222	5	2	9
24	R:R:L834	5.07	4	2	9
25	R:R:W838	11.1725	4	4	9
26	R:R:Y854	2.165	4	0	9
27	R:R:F859	5.7875	4	8	8
28	R:R:Q863	6.2375	4	4	9
29	R:R:F865	8.0075	4	5	7
30	R:R:F868	6.716	5	0	9
31	R:R:F870	4.5575	4	0	9
32	R:R:V878	5.465	4	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N763	39.6636	4.1	Yes	No	0	0	5
2	R:R:N763	R:R:W771	40.4394	13.56	No	Yes	0	5	9
3	R:R:L693	R:R:W771	30.8817	4.56	No	Yes	0	9	9
4	R:R:I670	R:R:L693	32.4273	5.71	No	No	0	6	9
5	R:R:F696	R:R:I670	33.5524	7.54	No	No	0	9	6
6	R:R:F696	R:R:Y695	34.873	5.16	No	Yes	0	9	9
7	R:R:W735	R:R:Y695	35.1691	5.79	Yes	Yes	1	9	9
8	R:R:Q659	R:R:W735	60.2002	5.48	Yes	Yes	1	7	9
9	R:R:I658	R:R:Q659	83.9048	4.12	No	Yes	0	9	7
10	R:R:I658	R:R:Y642	83.8159	3.63	No	Yes	0	9	9
11	R:R:K875	R:R:Y642	100	3.58	No	Yes	0	9	9
12	R:R:K875	R:R:V878	91.9938	6.07	No	Yes	3	9	9
13	R:R:V878	R:R:W882	88.1033	3.68	Yes	No	0	9	9
14	R:R:T641	R:R:W882	86.7354	9.7	Yes	No	0	9	9
15	R:R:C872	R:R:T641	84.6035	5.07	No	Yes	0	9	9
16	R:R:C872	R:R:F868	83.8692	6.98	No	Yes	0	9	9
17	R:R:F634	R:R:F868	33.8722	15	Yes	Yes	0	9	9
18	R:R:F634	R:R:F865	29.2829	10.72	Yes	Yes	5	9	7
19	R:R:F865	R:R:F866	56.6649	6.43	Yes	No	0	7	9
20	R:R:F866	R:R:L862	23.8704	6.09	No	No	0	9	7
21	R:R:G627	R:R:L862	21.2649	3.42	No	No	0	9	7
22	R:R:G627	R:R:T861	16.0182	3.64	No	No	0	9	8
23	R:R:C628	R:R:T861	13.3772	3.38	No	No	0	9	8
24	R:R:C628	R:R:L672	10.7242	4.76	No	No	0	9	9
25	R:R:F868	R:R:I869	38.7517	5.02	Yes	No	0	9	6
26	R:R:F865	R:R:I869	30.0113	8.79	Yes	No	0	7	6
27	R:R:F868	R:R:T638	18.2566	5.19	Yes	No	0	9	9
28	R:R:C661	R:R:T638	16.7999	5.07	No	No	0	9	9
29	R:R:C661	R:R:L635	12.3586	3.17	No	No	0	9	9
30	L:L:?1	R:R:F856	23.0592	7.27	Yes	No	0	0	9
31	R:R:F856	R:R:N860	24.0777	16.92	No	No	0	9	9
32	R:R:N860	R:R:W838	24.5574	18.08	No	Yes	0	9	9
33	R:R:Q863	R:R:W838	27.8261	8.76	Yes	Yes	4	9	9
34	R:R:L664	R:R:Q863	40.2736	6.65	No	Yes	0	9	9
35	R:R:L660	R:R:L664	41.6	5.54	No	No	0	9	9
36	R:R:E707	R:R:L660	42.2929	14.58	No	No	0	9	9
37	R:R:E707	R:R:L833	21.5136	11.93	No	No	0	9	9
38	R:R:L833	R:R:Y871	21.3419	14.07	No	No	0	9	8
39	R:R:L657	R:R:Y871	21.6083	5.86	No	No	0	9	8
40	R:R:I648	R:R:Q881	13.2173	5.49	No	No	0	8	9
41	R:R:E707	R:R:I656	26.9438	6.83	No	No	0	9	9
42	R:R:F730	R:R:I656	18.0435	5.02	Yes	No	0	8	9
43	R:R:F730	R:R:Y726	29.6737	17.54	Yes	Yes	0	8	8
44	R:R:W703	R:R:W735	18.8784	14.06	Yes	Yes	1	9	9
45	L:L:?1	R:R:T765	33.1971	5.87	Yes	No	0	0	5
46	R:R:P766	R:R:T765	30.26	8.74	No	No	0	5	5
47	R:R:F769	R:R:P766	20.874	4.33	No	No	0	9	5
48	R:R:D674	R:R:F769	17.7711	19.11	No	No	0	9	9
49	R:R:C770	R:R:D674	14.6444	7.78	No	No	0	9	9
50	R:R:C770	R:R:L679	11.3934	3.17	No	Yes	6	9	8
51	R:R:I772	R:R:W771	17.2796	11.74	No	Yes	0	8	9
52	R:R:H694	R:R:I772	11.3282	5.3	Yes	No	7	9	8
53	R:R:H694	R:R:L698	31.0179	9	Yes	No	0	9	9
54	R:R:L698	R:R:P738	32.3089	4.93	No	Yes	0	9	9
55	R:R:P738	R:R:V699	45.0702	5.3	Yes	No	0	9	7
56	R:R:F701	R:R:W838	14.8102	12.03	Yes	Yes	4	9	9
57	R:R:F701	R:R:F786	16.2433	10.72	Yes	No	0	9	9
58	R:R:P738	R:R:T702	33.6709	5.25	Yes	Yes	0	9	9
59	R:R:T702	R:R:Y785	29.5849	11.24	Yes	No	0	9	9
60	R:R:L706	R:R:W703	41.985	6.83	No	Yes	0	9	9
61	R:R:I789	R:R:Y785	26.8017	3.63	No	No	0	7	9
62	R:R:G705	R:R:I789	25.3923	3.53	No	No	0	8	7
63	R:R:G705	R:R:N793	23.9711	3.39	No	Yes	0	8	9
64	R:R:F709	R:R:F730	21.0872	4.29	No	Yes	0	7	8
65	R:R:L713	R:R:Y726	25.6943	5.86	Yes	Yes	0	5	8
66	R:R:F709	R:R:L713	19.7844	8.53	No	Yes	0	7	5
67	R:R:L834	R:R:N793	18.1678	8.24	Yes	Yes	0	9	9
68	R:R:L713	R:R:Y712	32.6819	3.52	Yes	No	0	5	9
69	R:R:V716	R:R:Y712	22.9466	11.36	No	No	0	9	9
70	R:R:V745	R:R:Y753	12.2579	6.31	No	Yes	0	8	9
71	R:R:V745	R:R:V777	10.8131	3.21	No	No	0	8	7
72	R:R:F786	R:R:F790	13.5548	7.5	No	No	0	9	9
73	R:R:V716	R:R:V799	19.6719	1.6	No	No	0	9	9
74	R:R:Q803	R:R:V799	16.3913	2.87	No	No	0	9	9
75	R:R:Q803	R:R:R806	13.2824	2.34	No	No	0	9	9
76	R:R:F832	R:R:F866	31.616	19.29	No	No	0	6	9
77	R:R:F832	R:R:T837	29.046	7.78	No	No	0	6	9
78	R:R:F859	R:R:T837	26.4641	7.78	Yes	No	0	8	9
79	R:R:F840	R:R:F859	18.606	4.29	No	Yes	8	9	8
80	R:R:F840	R:R:F843	16.0182	1.07	No	No	0	9	9
81	R:R:F843	R:R:F852	13.3772	4.29	No	No	0	9	9
82	L:L:?1	R:R:M853	10.0136	4.22	Yes	No	0	0	8
83	R:R:L657	R:R:Y642	21.8867	4.69	No	Yes	0	9	9
84	R:R:F730	R:R:L706	41.2092	6.09	Yes	No	0	8	9
85	R:R:Q659	R:R:W703	23.4796	15.33	Yes	Yes	1	7	9
86	R:R:H694	R:R:Y753	18.4994	14.16	Yes	Yes	7	9	9
87	R:R:V699	R:R:W735	43.6371	11.03	No	Yes	1	7	9
88	R:R:M704	R:R:Q863	11.4348	6.8	Yes	Yes	4	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L620	5.51	Yes	No	0	9	0	1
L:L:?1	R:R:N763	4.1	Yes	No	0	5	0	1
L:L:?1	R:R:T765	5.87	Yes	No	0	5	0	1
L:L:?1	R:R:M853	4.22	Yes	No	0	8	0	1
L:L:?1	R:R:F856	7.27	Yes	No	0	9	0	1
R:R:N763	R:R:W771	13.56	No	Yes	5	9	1	2
R:R:P766	R:R:T765	8.74	No	No	5	5	2	1
R:R:A841	R:R:F856	5.55	No	No	9	9	2	1
R:R:F856	R:R:N860	16.92	No	No	9	9	1	2
L:L:?1	R:R:P762	3.27	Yes	No	0	3	0	1
R:R:P762	R:R:W845	2.7	No	No	3	8	1	2
R:R:M853	R:R:Y854	2.39	No	Yes	8	9	1	2
R:R:A844	R:R:M853	1.61	No	No	9	8	2	1
L:L:?1	R:R:A857	1.57	Yes	No	0	7	0	1
R:R:T621	R:R:T765	1.57	No	No	9	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XKE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.58
Number of Linked Nodes	238
Number of Links	253
Number of Hubs	32
Number of Links mediated by Hubs	120
Number of Communities	8
Number of Nodes involved in Communities	31
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	35887
Length Of Smallest Path	3
Average Path Length	16.2276
Length of Longest Path	37
Minimum Path Strength	1.43
Average Path Strength	6.93126
Maximum Path Strength	19.69
Minimum Path Correlation	0.7
Average Path Correlation	0.93553
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	47.3576
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.851
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • spermatid development • spermatid differentiation • sexual reproduction • cellular developmental process • spermatogenesis • reproductive process • multicellular organismal reproductive process • cell development • cellular process involved in reproduction in multicellular organism • developmental process involved in reproduction • gamete generation • male gamete generation • cell differentiation • anatomical structure development • germ cell development • cell surface receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • cell periphery • cellular anatomical structure • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • intracellular anatomical structure • cytoplasm • cytosol • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AND
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	AND
Name	Prasterone
Synonyms	Dehydroisoandrosterone
Identifier
Formula	C19 H28 O2
Molecular Weight	288.424
SMILES
PubChem	5881
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	6
Total Bonds	52
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8CJ12
Sequence	>7XKE_nogp_Chain_R M A L T F I T Y I G C G L S S I F L S V T L V T Y I A F E K I R R D Y P S K I L I Q L C A A L L L L N L I F L L D S W I A L Y N T R G F C I A V A V F L H Y F L L V S F T W M G L E A F H M Y L A L V K V F N T Y I R K Y I L K F C I V G W G I P A V V V S I V L T I S P D N Y G I P N G T P D D F C W I N S N V V F Y I T V V G Y F C V I F L L N V S M F I V V L V Q L C R I K K K K Q L G I Q D L R S I A G L T F L L G I T W G F A F F A W G V N V T F M Y L F A I F N T L Q G F F I F I F Y C A A K E N V R K Q W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WUI	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	IP15	-	chim(NtGi1-Gs)/β1/γ2	3.1	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7WUI (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	IP15	-		3.1	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7WUQ	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-	Gs/β1/γ2	2.9	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7WUQ (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-		2.9	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7XKD	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-	Gs/β1/γ2	2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKD (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-		2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKE	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKE (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-		2.9	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKF	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-	Gs/β1/γ2	2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKF (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-		2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7YP7	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-	Gs/β1/γ2	3.1	2022-08-24	doi.org/10.1038/s41589-022-01084-6
	7YP7 (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-		3.1	2022-08-24	doi.org/10.1038/s41589-022-01084-6
	8YKD	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-	chim(NtGi1-Gs)/β1/γ2	2.9	2025-08-13	doi.org/10.1038/s41589-025-01896-2
	8YKD (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-		2.9	2025-08-13	doi.org/10.1038/s41589-025-01896-2

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.