Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 7.655414
2A:A:R42 7.26419
3A:A:L45 5.3225458
4A:A:L46 3.034168
5A:A:S51 5.4125459
6A:A:T55 6.256559
7A:A:I56 4.798557
8A:A:V214 6.7446
9A:A:F219 4.71167608
10A:A:H220 8.96517
11A:A:F222 9.1417
12A:A:Q227 4.962569
13A:A:R228 5.35489
14A:A:K233 4.192589
15A:A:C237 3.615418
16A:A:F238 7.6425409
17A:A:F273 7.515409
18A:A:W277 10.186506
19A:A:W281 10.155615
20A:A:I288 2.84409
21A:A:L289 4.225409
22A:A:F290 6.588559
23A:A:N292 6.736559
24A:A:K293 4.6825459
25A:A:F315 9.4775406
26A:A:E330 4.662503
27A:A:D331 9.665404
28A:A:V334 5.1725404
29A:A:F340 7.796507
30A:A:R342 6.28754184
31A:A:Y360 15.9454158
32A:A:T364 6.51459
33A:A:N371 7.496559
34A:A:R373 7.07445
35A:A:F376 7.328548
36A:A:I383 4.415448
37A:A:R385 8.874155
38A:A:Y391 6.69254104
39A:A:L393 3.36408
40A:A:L394 3.625408
41B:B:I18 2.7925407
42B:B:L30 3.6225405
43B:B:T34 3.315135
44B:B:I37 4.59254132
45B:B:V40 2.725403
46B:B:M45 4.6875494
47B:B:H54 7.43619
48B:B:K57 8.956519
49B:B:Y59 7.044518
50B:B:W63 5.676507
51B:B:V71 4.44408
52B:B:Q75 8.03419
53B:B:D76 6.96519
54B:B:I80 7.6325418
55B:B:W82 8.55619
56B:B:K89 5.14667619
57B:B:W99 9.63833619
58B:B:M101 4.416519
59B:B:Y105 3.48606
60B:B:Y111 6.4225404
61B:B:H142 7.64569
62B:B:Y145 6.268508
63B:B:D163 5.63569
64B:B:W169 9.04668
65B:B:I171 3.0954226
66B:B:F180 7.418577
67B:B:H183 6.67714779
68B:B:D186 5.655489
69B:B:V187 5.0225479
70B:B:F199 5.63679
71B:B:V200 5.885426
72B:B:S201 4.915479
73B:B:C204 4.488587
74B:B:D205 5.0025479
75B:B:K209 7.912576
76B:B:W211 7.99667678
77B:B:F222 6.6975428
78B:B:H225 9.69667629
79B:B:D228 6.79589
80B:B:I232 4.71428
81B:B:F235 6.288758116
82B:B:P236 6.37754117
83B:B:F241 5.97333626
84B:B:T243 5.142528
85B:B:D247 8.326529
86B:B:T249 6.415426
87B:B:R251 9.47667628
88B:B:F253 5.918526
89B:B:D258 8.124527
90B:B:Q259 4.4175406
91B:B:E260 5.6025426
92B:B:M262 5.73404
93B:B:Y264 6.34505
94B:B:F278 3.4265117
95B:B:R283 8.46754139
96B:B:Y289 5.935717237
97B:B:V296 3.45405
98B:B:K301 5.6954135
99B:B:H311 9.99499
100B:B:R314 13.7175418
101B:B:T329 4.544598
102B:B:W332 10.3071719
103B:B:D333 7.8825499
104B:B:K337 5.888596
105B:B:W339 7.10667699
106B:B:N340 5.72409
107G:G:V16 3.1825407
108G:G:L19 2.838509
109G:G:R27 6.055428
110G:G:Y40 8.7954116
111G:G:D48 6.895409
112G:G:L51 4.592506
113G:G:P60 7.12754199
114G:G:F61 5.417198
115R:R:T624 3.5375409
116R:R:C628 3.1175409
117R:R:F634 7.75409
118R:R:Y642 3.95409
119R:R:Y652 7.73254108
120R:R:P653 6.6085109
121R:R:V689 4.9175408
122R:R:H694 6.7425439
123R:R:Y695 5.4125439
124R:R:L698 4439
125R:R:W703 8.02754249
126R:R:H710 4.9785109
127R:R:F719 5.23143749
128R:R:Y726 9.315108
129R:R:W735 4.884249
130R:R:P738 3.505639
131R:R:Y753 10.7754259
132R:R:W771 6.38439
133R:R:F778 5.7075439
134R:R:T781 4.068537
135R:R:Y785 4.0425439
136R:R:F786 7.1654149
137R:R:F832 8.9854126
138R:R:L834 5.4454269
139R:R:W838 8.4225149
140R:R:F859 5.82754128
141R:R:Q863 4.53409
142R:R:F865 4.5354127
143R:R:F868 8.035409
144R:R:F870 6.3125409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:H54 15.2025.04YesYes199
2A:A:F238 A:A:L44 84.395615.83YesNo099
3A:A:L44 A:A:L46 84.02162.77NoYes1698
4A:A:F246 A:A:L46 83.92153.65NoYes098
5A:A:F246 A:A:L289 83.88324.87NoYes099
6A:A:L289 A:A:L291 77.83352.77YesNo098
7A:A:F363 A:A:L291 77.55696.09NoNo058
8A:A:F363 A:A:K338 77.46399.93NoNo055
9A:A:E330 A:A:K338 77.18326.75YesNo035
10A:A:E330 A:A:V334 76.5164.28YesYes034
11A:A:V301 A:A:V334 75.65773.21NoYes074
12A:A:K300 A:A:V301 75.68226.07NoNo097
13A:A:K300 A:A:S251 75.58173.06NoNo099
14A:A:D295 A:A:S251 75.37994.42NoNo099
15A:A:D295 A:A:K293 75.17665.53NoYes099
16A:A:K293 A:A:N292 74.44534.2YesYes599
17A:A:N292 A:A:T364 71.80795.85YesYes599
18A:A:F290 A:A:T364 70.88736.49YesYes599
19A:A:F290 A:A:I288 71.89423.77YesYes099
20A:A:D378 A:A:I288 71.82862.8NoYes079
21A:A:D378 A:A:Y360 71.370924.14NoYes078
22A:A:R385 A:A:Y360 70.89068.23YesYes1558
23A:A:L394 A:A:R385 70.90713.64YesYes085
24A:A:L388 A:A:L394 70.08344.15NoYes088
25A:A:L388 R:R:L715 69.96435.54NoNo088
26R:R:A714 R:R:L715 69.72523.15NoNo098
27A:A:H387 R:R:A714 69.60514.39NoNo089
28A:A:H387 A:A:Q390 67.00472.47NoNo084
29A:A:Q390 R:R:P653 65.18167.9NoYes1049
30R:R:P653 R:R:Y652 25.12814.17YesYes1098
31R:R:Y652 R:R:Y726 24.544819.86YesYes1088
32R:R:H710 R:R:P653 26.80364.58YesYes1099
33R:R:H710 R:R:Y726 26.64686.53YesYes1098
34A:A:Q227 B:B:Y145 12.97927.89YesYes098
35B:B:M101 B:B:Y145 17.35097.18YesYes098
36B:B:M101 B:B:Y59 10.28653.59YesYes198
37B:B:W332 B:B:Y59 79.70456.75YesYes198
38B:B:S316 B:B:W332 81.33317.41NoYes099
39B:B:C317 B:B:S316 81.34793.44NoNo079
40B:B:C317 B:B:M61 81.36554.86NoNo076
41A:A:Q227 B:B:G144 10.70073.29YesNo698
42A:A:C237 B:B:Y59 68.63885.38YesYes188
43A:A:F345 A:A:L289 11.77136.09NoYes089
44A:A:Y391 R:R:P653 13.72118.34YesYes1049
45A:A:Y391 R:R:M711 13.39228.38YesNo049
46R:R:F832 R:R:T831 10.47779.08YesNo068
47R:R:F797 R:R:T831 10.68653.89NoNo098
48R:R:F797 R:R:L834 11.04693.65NoYes099
49R:R:L834 R:R:M711 12.98434.24YesNo099
50B:B:M325 G:G:P60 23.48075.03NoYes059
51B:B:M325 G:G:P49 1006.71NoNo057
52G:G:D48 G:G:P49 99.71224.83YesNo097
53B:B:S281 G:G:D48 62.34985.89NoYes099
54B:B:S281 G:G:H44 62.24412.79NoNo096
55G:G:H44 G:G:Y40 62.03518.51NoYes066
56B:B:F235 G:G:Y40 30.54874.13YesYes1166
57B:B:F235 B:B:F278 29.92916.43YesYes1167
58B:B:F278 B:B:L285 58.77023.65YesNo076
59B:B:L285 B:B:Y264 58.46864.69NoYes065
60B:B:C250 B:B:Y264 77.90494.03NoYes085
61B:B:C250 B:B:I273 77.43033.27NoNo086
62B:B:G244 B:B:I273 77.42143.53NoNo056
63B:B:G244 B:B:T243 75.49893.64NoYes058
64B:B:F253 B:B:T243 56.86927.78YesYes268
65B:B:F222 B:B:F253 51.52764.29YesYes286
66B:B:D258 B:B:F222 50.39883.58YesYes278
67B:B:D258 B:B:R22 47.922715.48YesNo076
68B:B:I18 B:B:R22 41.90523.76YesNo076
69B:B:I18 G:G:L19 10.03071.43YesYes079
70B:B:P236 G:G:Y40 30.04045.56YesYes1176
71B:B:F278 B:B:P236 29.76482.89YesYes1177
72G:G:D48 G:G:L51 35.52059.5YesYes096
73B:B:R283 G:G:L51 32.55774.86YesYes096
74B:B:I37 B:B:R283 31.5913.76YesYes1329
75B:B:I37 B:B:T34 31.163.04YesYes1325
76B:B:L30 B:B:T34 31.51962.95YesYes055
77B:B:L30 B:B:M262 30.92234.24YesYes054
78B:B:M262 B:B:Y264 30.507210.78YesYes045
79B:B:N340 G:G:F61 11.76214.83YesYes098
80B:B:M45 B:B:N340 15.70562.8YesYes049
81B:B:M45 B:B:W339 13.97294.65YesYes949
82B:B:M61 B:B:W63 86.4965.82NoYes067
83B:B:T321 B:B:W63 76.712810.92NoYes077
84B:B:D163 B:B:G144 10.51423.35YesNo698
85B:B:D323 B:B:M325 76.6865.54NoNo075
86B:B:I18 G:G:E22 30.2342.73YesNo079
87B:B:T221 G:G:E22 18.25078.47NoNo079
88B:B:K209 B:B:T221 17.73517.51YesNo067
89B:B:K209 B:B:W211 10.44258.12YesYes768
90B:B:F199 B:B:W211 11.507112.03YesYes798
91G:G:E22 G:G:Q18 11.47193.82NoNo099
92B:B:C218 G:G:Q18 10.95793.05NoNo059
93B:B:C218 B:B:W211 10.43975.22NoYes758
94B:B:I232 B:B:T243 11.68233.04YesYes288
95B:B:W297 B:B:Y264 10.05398.68NoYes085
96R:R:F730 R:R:Y726 48.5739.28NoYes088
97R:R:F730 R:R:L706 46.80117.31NoNo089
98R:R:L706 R:R:V733 43.752.98NoNo094
99R:R:I737 R:R:V733 43.3673.07NoNo044
100R:R:I737 R:R:P738 31.74883.39NoYes049
101R:R:L698 R:R:P738 27.41853.28YesYes399
102R:R:H694 R:R:L698 26.68127.71YesYes399
103R:R:H694 R:R:V782 14.17962.77YesNo399
104R:R:F778 R:R:V782 13.95449.18YesNo399
105R:R:F778 R:R:W771 11.10916.01YesYes399
106R:R:F769 R:R:W771 10.2992NoYes099
107R:R:H694 R:R:T781 10.534710.95YesYes397
108R:R:S774 R:R:V777 18.71854.85NoNo077
109R:R:N752 R:R:S774 17.0981.49NoNo087
110R:R:N752 R:R:S749 16.28727.45NoNo086
111R:R:D751 R:R:S749 14.66462.94NoNo046
112R:R:D751 R:R:R683 13.85287.15NoNo045
113R:R:I737 R:R:V740 11.26111.54NoNo045
114R:R:S743 R:R:V740 10.86131.62NoNo075
115R:R:I744 R:R:S743 10.46881.55NoNo087
116R:R:I744 R:R:V745 10.07711.54NoNo088
117B:B:D323 B:B:T321 76.55038.67NoNo2077
118G:G:F61 G:G:P60 14.10827.22YesYes1989
119A:A:C237 A:A:F238 76.24142.79YesYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7YP7
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRG2
Species Mus musculus
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.1
Date 2022-08-24
D.O.I. 10.1038/s41589-022-01084-6
Net Summary
Imin 2.77
Number of Linked Nodes 833
Number of Links 970
Number of Hubs 144
Number of Links mediated by Hubs 524
Number of Communities 26
Number of Nodes involved in Communities 204
Number of Links involved in Communities 289
Path Summary
Number Of Nodes in MetaPath 120
Number Of Links MetaPath 119
Number of Shortest Paths 924336
Length Of Smallest Path 3
Average Path Length 40.9743
Length of Longest Path 88
Minimum Path Strength 1.185
Average Path Strength 5.99142
Maximum Path Strength 25.475
Minimum Path Correlation 0.71
Average Path Correlation 0.97541
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.38889
Average % Of Corr. Nodes 38.177
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.9679
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7YP7_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKQSGI FETKFQVDK VNFHMFDVG AQRDERRKW IQCFNDVTA 
IIFVVASSS YNMTNRLQA ALKLFDSIW NNKWLRDTS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCAV DTENIRRVF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7YP7_Chain_B
QSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7YP7_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8CJ12
Sequence
>7YP7_Chain_R
ALTFITYIG CGLSSIFLS VTLVTYIAF EKIRRDYPS KILIQLCAA 
LLLLNLIFL LDSWIALYN TRGFCIAVA VFLHYFLLV SFTWMGLEA 
FHMYLALVK VFNTYIRKY ILKFCIVGW GIPAVVVSI VLTISPDNY 
GDDFCWINS NVVFYITVV GYFCVIFLL NVSMFIVVL VQLCRIKKK 
KSIQDLRSI AGLTFLLGI TWGFAFFAW GPVNVTFMY LFAIFNTLQ 
GFFIFIFYC AAKENVRKQ WRRY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WUIB2AdhesionAdhesionADGRG2Mus musculusIP15-chim(NtGi1-Gs)/&β;1/&γ;23.12022-04-2710.1038/s41586-022-04590-8
7WUQB2AdhesionAdhesionADGRG2Mus musculus--Gs/&β;1/&γ;22.92022-04-2710.1038/s41586-022-04590-8
7XKDB2AdhesionAdhesionADGRG2Mus musculusBetahydroxyandrosterone-Gs/&β;1/&γ;22.42022-08-1010.1038/s41589-022-01084-6
7XKEB2AdhesionAdhesionADGRG2Mus musculusBetahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;22.92022-08-1010.1038/s41589-022-01084-6
7XKFB2AdhesionAdhesionADGRG2Mus musculusBetahydroxyandrosterone-Gs/&β;1/&γ;22.42022-08-1010.1038/s41589-022-01084-6
7YP7B2AdhesionAdhesionADGRG2Mus musculus--Gs/&β;1/&γ;23.12022-08-2410.1038/s41589-022-01084-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7YP7.zip



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