Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 7.655414
2A:A:H41 4.555446
3A:A:R42 7.26419
4A:A:L46 3.03418
5A:A:S51 4.67559
6A:A:T55 5.36559
7A:A:I56 8.35457
8A:A:V214 5.884546
9A:A:V217 4.7125445
10A:A:F219 4.71167648
11A:A:H220 8.96517
12A:A:F222 7.782517
13A:A:Q227 4.57833619
14A:A:R228 5.35479
15A:A:K233 4.192579
16A:A:C237 3.615418
17A:A:F238 6.602519
18A:A:F246 4.3075409
19A:A:V248 3.005487
20A:A:Y253 7.762508
21A:A:F273 6.54589
22A:A:W277 10.186586
23A:A:W281 10.155615
24A:A:I288 2.84409
25A:A:L289 4.225489
26A:A:F290 6.98459
27A:A:L291 4.356588
28A:A:N292 6.444559
29A:A:K293 4.3459
30A:A:F312 2.67408
31A:A:F315 9.4775406
32A:A:E330 4.662503
33A:A:D331 9.665404
34A:A:V334 6.2365204
35A:A:F340 7.796507
36A:A:R342 6.28754214
37A:A:F345 6.71488
38A:A:Y360 15.9454138
39A:A:T364 6.1175459
40A:A:N371 7.496559
41A:A:R373 7.07445
42A:A:F376 6.54333648
43A:A:I383 4.415448
44A:A:R385 7.5985135
45A:A:Y391 6.6925414
46A:A:L393 3.36408
47A:A:L394 3.6254138
48B:B:I18 2.7925407
49B:B:L30 3.6225405
50B:B:T34 3.315165
51B:B:I37 4.59254162
52B:B:V40 2.725403
53B:B:M45 4.6875494
54B:B:H54 6.74286719
55B:B:K57 8.956519
56B:B:Y59 7.044518
57B:B:W63 5.676507
58B:B:V71 4.44408
59B:B:Q75 8.03419
60B:B:D76 6.96519
61B:B:K78 4.8175418
62B:B:I80 7.6325418
63B:B:W82 8.55619
64B:B:Y85 10.01754144
65B:B:K89 5.14667619
66B:B:W99 9.63833619
67B:B:M101 4.416519
68B:B:Y105 3.342867236
69B:B:N110 4.74754174
70B:B:Y111 6.42254174
71B:B:L117 3.926519
72B:B:Y124 5.0354256
73B:B:H142 6.82333619
74B:B:Y145 5.64667608
75B:B:D163 5.63519
76B:B:W169 9.04618
77B:B:I171 3.0954266
78B:B:F180 7.418567
79B:B:H183 6.67714769
80B:B:D186 5.655479
81B:B:V187 5.0225469
82B:B:F199 5.63669
83B:B:V200 5.885426
84B:B:S201 4.915469
85B:B:C204 4.488577
86B:B:D205 5.0025469
87B:B:K209 7.912566
88B:B:W211 7.99667668
89B:B:F222 6.6975428
90B:B:H225 8.70286729
91B:B:D228 6.79579
92B:B:I232 4.71428
93B:B:F235 6.288758116
94B:B:P236 6.37754117
95B:B:F241 5.49726
96B:B:T243 4.71667628
97B:B:D247 8.326529
98B:B:T249 5.68526
99B:B:R251 9.47667628
100B:B:F253 5.918526
101B:B:D254 3.6575409
102B:B:D258 8.124527
103B:B:Q259 4.4175406
104B:B:E260 5.6025426
105B:B:M262 5.734224
106B:B:Y264 5.728336225
107B:B:I269 3.53754154
108B:B:F278 3.4265117
109B:B:R283 8.46754169
110B:B:Y289 5.935717157
111B:B:V296 3.45405
112B:B:K301 5.6954165
113B:B:R304 8.03754155
114B:B:H311 9.99499
115B:B:R314 13.7175418
116B:B:T329 4.544598
117B:B:W332 10.3071719
118B:B:D333 7.8825499
119B:B:K337 5.888596
120B:B:W339 7.10667699
121B:B:N340 5.72409
122G:G:V16 3.1825407
123G:G:L19 2.838509
124G:G:R27 6.055428
125G:G:Y40 8.7954116
126G:G:D48 6.895409
127G:G:L51 4.592506
128G:G:P60 7.12754149
129G:G:F61 5.417148
130R:R:T624 3.5375409
131R:R:C628 3.1175409
132R:R:F634 7.75409
133R:R:Y642 3.66509
134R:R:Y652 6.584518
135R:R:P653 6.608519
136R:R:V689 4.9175408
137R:R:H694 5.924539
138R:R:Y695 5.4125439
139R:R:L698 4439
140R:R:W703 6.9445189
141R:R:H710 4.978519
142R:R:F719 5.23143749
143R:R:Y722 5416
144R:R:Y726 9.31518
145R:R:W735 4.4265189
146R:R:P738 3.505639
147R:R:Y753 8.3354279
148R:R:W771 6.38439
149R:R:F778 5.7075439
150R:R:T781 4.068537
151R:R:Y785 4.0425439
152R:R:F786 7.1654129
153R:R:F790 4.224129
154R:R:F797 3.7125409
155R:R:F832 8.9854106
156R:R:L834 5.4454129
157R:R:I836 2.794129
158R:R:T837 5.63754109
159R:R:W838 8.4225129
160R:R:F840 4.47254109
161R:R:F859 5.82754108
162R:R:L862 2.95254107
163R:R:Q863 4.53409
164R:R:F865 4.5354107
165R:R:F866 6.6454109
166R:R:F868 8.035409
167R:R:F870 6.3125409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:I80 23.29899.28YesYes198
2B:B:D76 B:B:H54 53.96595.04YesYes199
3B:B:D76 B:B:L55 52.21059.5YesNo196
4A:A:K34 B:B:L55 1007.05NoNo146
5A:A:K34 R:R:Y722 99.55588.36NoYes146
6R:R:Y652 R:R:Y722 99.21091.99YesYes186
7R:R:Y652 R:R:Y726 36.098719.86YesYes188
8A:A:R42 A:A:Y37 51.021317.49YesYes194
9A:A:H387 A:A:I383 13.4813.98NoYes088
10A:A:H387 A:A:Q390 17.90832.47NoNo084
11A:A:Q390 R:R:P653 17.79267.9NoYes149
12R:R:P653 R:R:Y652 41.74624.17YesYes198
13A:A:F222 A:A:R42 50.53764.28YesYes179
14A:A:F238 A:A:L44 25.55215.83YesNo199
15A:A:F222 B:B:W99 29.932416.04YesYes179
16A:A:L44 A:A:L46 25.07852.77NoYes198
17A:A:F246 A:A:L46 24.74883.65YesYes098
18B:B:C317 B:B:M61 10.01044.86NoNo076
19B:B:L70 B:B:M61 18.28342.83NoNo056
20B:B:L70 B:B:W82 18.28815.69NoYes059
21A:A:F222 A:A:I207 21.78672.51YesNo179
22A:A:I207 B:B:L117 21.82967.14NoYes199
23B:B:L117 B:B:W99 21.8754.56YesYes199
24A:A:Q227 B:B:L117 31.95672.66YesYes199
25B:B:W332 B:B:Y59 10.25716.75YesYes198
26B:B:M101 B:B:Y145 32.57557.18YesYes098
27A:A:F246 A:A:L289 19.81924.87YesYes099
28A:A:F345 A:A:L289 11.51936.09YesYes889
29A:A:L393 A:A:Y391 16.38583.52YesYes084
30A:A:Y391 R:R:P653 22.30498.34YesYes149
31A:A:Y391 R:R:H710 21.61936.53YesYes149
32R:R:H710 R:R:Y652 24.273.27YesYes198
33A:A:Y391 R:R:M711 27.06348.38YesNo049
34A:A:L393 R:R:L830 12.75844.15YesNo088
35B:B:S147 B:B:Y145 50.90262.54NoYes098
36B:B:S147 B:B:S160 50.63544.89NoNo096
37B:B:S160 B:B:V187 50.37274.85NoYes069
38B:B:H183 B:B:V187 39.10816.92YesYes699
39B:B:H183 B:B:K209 32.659715.72YesYes696
40B:B:K209 B:B:T221 31.84577.51YesNo067
41B:B:T221 G:G:E22 31.59088.47NoNo079
42B:B:I18 G:G:E22 31.93282.73YesNo079
43B:B:I18 B:B:R22 26.05553.76YesNo076
44B:B:D258 B:B:R22 22.97415.48YesNo076
45B:B:M325 G:G:P60 32.09095.03NoYes059
46B:B:M325 G:G:P49 52.73486.71NoNo057
47G:G:D48 G:G:P49 51.48754.83YesNo097
48G:G:D48 G:G:L51 20.95319.5YesYes096
49B:B:R283 G:G:L51 14.60024.86YesYes096
50B:B:I37 B:B:R283 12.74233.76YesYes1629
51B:B:I37 B:B:T34 11.87063.04YesYes1625
52B:B:L30 B:B:T34 11.83922.95YesYes055
53B:B:L30 B:B:M262 11.15634.24YesYes054
54B:B:N340 G:G:F61 12.54784.83YesYes098
55B:B:M45 B:B:N340 13.68432.8YesYes049
56B:B:M45 B:B:W339 12.17264.65YesYes949
57B:B:L51 B:B:W82 22.74310.25NoYes199
58B:B:L51 B:B:T87 33.70152.95NoNo095
59B:B:R49 B:B:T87 33.46365.17NoNo075
60B:B:R49 G:G:F61 33.25658.55NoYes1478
61B:B:H54 B:B:I58 11.35857.95YesNo099
62B:B:I58 B:B:L336 11.25214.28NoNo097
63B:B:S72 B:B:W82 20.037.41NoYes099
64B:B:M61 B:B:W63 26.69715.82NoYes067
65B:B:T321 B:B:W63 21.271710.92NoYes077
66B:B:D323 B:B:M325 20.96765.54NoNo075
67B:B:S201 B:B:V187 10.13553.23YesYes699
68B:B:S281 G:G:D48 26.35615.89NoYes099
69B:B:S281 G:G:H44 26.07842.79NoNo096
70G:G:H44 G:G:Y40 25.568918.51NoYes066
71B:B:F235 G:G:Y40 12.50034.13YesYes1166
72B:B:F235 B:B:F278 10.53126.43YesYes1167
73B:B:F278 B:B:L285 19.08983.65YesNo076
74B:B:L285 B:B:Y264 18.51184.69NoYes065
75B:B:G244 B:B:I273 11.17133.53NoNo056
76B:B:G244 B:B:T243 13.02243.64NoYes058
77B:B:P236 G:G:Y40 10.92385.56YesYes1176
78B:B:F278 B:B:P236 10.35812.89YesYes1177
79B:B:M262 B:B:Y264 10.323210.78YesYes2245
80B:B:F222 B:B:F241 12.336310.72YesYes286
81B:B:W297 B:B:Y264 18.07838.68NoYes085
82B:B:W297 B:B:Y289 10.06923.86NoYes087
83R:R:F730 R:R:Y726 36.66129.28NoYes088
84R:R:F730 R:R:L706 34.90287.31NoNo089
85R:R:L706 R:R:V733 32.72672.98NoNo094
86R:R:I737 R:R:V733 32.4563.07NoNo044
87R:R:I737 R:R:P738 24.3593.39NoYes049
88R:R:L698 R:R:P738 21.18173.28YesYes399
89R:R:H694 R:R:L698 20.65987.71YesYes399
90R:R:F797 R:R:L830 12.24612.44YesNo098
91R:R:F797 R:R:T831 22.43413.89YesNo098
92R:R:F832 R:R:T831 21.40739.08YesNo068
93R:R:L834 R:R:M711 26.03484.24YesNo099
94R:R:F797 R:R:L834 12.30133.65YesYes099
95R:R:I836 R:R:L834 11.27524.28YesYes1299
96R:R:S774 R:R:V777 13.23374.85NoNo077
97R:R:N752 R:R:S774 12.08771.49NoNo087
98R:R:N752 R:R:S749 11.51447.45NoNo086
99R:R:D751 R:R:S749 10.36712.94NoNo046
100B:B:D323 B:B:T321 20.98528.67NoNo2477
101B:B:D258 B:B:F222 21.96313.58YesYes278
102G:G:F61 G:G:P60 27.70457.22YesYes1489
103A:A:Q227 B:B:Y145 26.4587.89YesYes098
104B:B:L117 B:B:M101 25.14932.83YesYes199
105B:B:H54 B:B:S72 20.07018.37YesNo099
106B:B:I80 B:B:W82 20.133915.27YesYes189
107B:B:L336 B:B:L51 11.20765.54NoNo179
108A:A:Y37 B:B:L55 47.98715.86YesNo146
109A:A:F238 B:B:L117 10.67562.44YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7YP7
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRG2
Species Mus Musculus
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.1
Date 2022-08-24
D.O.I. 10.1038/s41589-022-01084-6
Net Summary
Imin 2.44
Number of Linked Nodes 828
Number of Links 1010
Number of Hubs 167
Number of Links mediated by Hubs 601
Number of Communities 27
Number of Nodes involved in Communities 245
Number of Links involved in Communities 360
Path Summary
Number Of Nodes in MetaPath 110
Number Of Links MetaPath 109
Number of Shortest Paths 1399527
Length Of Smallest Path 3
Average Path Length 26.2958
Length of Longest Path 50
Minimum Path Strength 1.185
Average Path Strength 6.14632
Maximum Path Strength 25.475
Minimum Path Correlation 0.7
Average Path Correlation 0.9785
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 44.3072
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.2677
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell surface receptor signaling pathway   • apical part of cell   • plasma membrane region   • apical plasma membrane
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7YP7_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKQSGI FETKFQVDK VNFHMFDVG AQRDERRKW IQCFNDVTA 
IIFVVASSS YNMTNRLQA ALKLFDSIW NNKWLRDTS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCAV DTENIRRVF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7YP7_Chain_B
QSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7YP7_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8CJ12
Sequence
>7YP7_Chain_R
ALTFITYIG CGLSSIFLS VTLVTYIAF EKIRRDYPS KILIQLCAA 
LLLLNLIFL LDSWIALYN TRGFCIAVA VFLHYFLLV SFTWMGLEA 
FHMYLALVK VFNTYIRKY ILKFCIVGW GIPAVVVSI VLTISPDNY 
GDDFCWINS NVVFYITVV GYFCVIFLL NVSMFIVVL VQLCRIKKK 
KSIQDLRSI AGLTFLLGI TWGFAFFAW GPVNVTFMY LFAIFNTLQ 
GFFIFIFYC AAKENVRKQ WRRY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YP7B2AdhesionAdhesionADGRG2Mus musculus--Gs/β1/γ23.12022-08-2410.1038/s41589-022-01084-6
7YP7 (No Gprot) B2AdhesionAdhesionADGRG2Mus musculus--3.12022-08-2410.1038/s41589-022-01084-6
7XKEB2AdhesionAdhesionADGRG2Mus musculusβ-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ22.92022-08-1010.1038/s41589-022-01084-6
7XKE (No Gprot) B2AdhesionAdhesionADGRG2Mus musculusβ-Hydroxyandrosterone-2.92022-08-1010.1038/s41589-022-01084-6
7XKFB2AdhesionAdhesionADGRG2Mus musculusβ-Hydroxyandrosterone-Gs/β1/γ22.42022-08-1010.1038/s41589-022-01084-6
7XKF (No Gprot) B2AdhesionAdhesionADGRG2Mus musculusβ-Hydroxyandrosterone-2.42022-08-1010.1038/s41589-022-01084-6
7XKDB2AdhesionAdhesionADGRG2Mus musculusβ-Hydroxyandrosterone-Gs/β1/γ22.42022-08-1010.1038/s41589-022-01084-6
7XKD (No Gprot) B2AdhesionAdhesionADGRG2Mus musculusβ-Hydroxyandrosterone-2.42022-08-1010.1038/s41589-022-01084-6
7WUIB2AdhesionAdhesionADGRG2Mus musculusIP15-chim(NtGi1-Gs)/β1/γ23.12022-04-2710.1038/s41586-022-04590-8
7WUI (No Gprot) B2AdhesionAdhesionADGRG2Mus musculusIP15-3.12022-04-2710.1038/s41586-022-04590-8
7WUQB2AdhesionAdhesionADGRG2Mus musculus--Gs/β1/γ22.92022-04-2710.1038/s41586-022-04590-8
7WUQ (No Gprot) B2AdhesionAdhesionADGRG2Mus musculus--2.92022-04-2710.1038/s41586-022-04590-8




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