psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T624	10.26	Yes	No	0	0	9
2	L:L:?1	R:R:L667	9.64	Yes	No	0	0	9
3	L:L:?1	R:R:N668	5.46	Yes	No	0	0	9
4	L:L:?1	R:R:F671	18.17	Yes	No	0	0	9
5	L:L:?1	R:R:W838	5.67	Yes	Yes	2	0	9
6	L:L:?1	R:R:F856	21.81	Yes	Yes	2	0	9
7	L:L:?1	R:R:T861	4.4	Yes	No	0	0	8
8	R:R:L620	R:R:Y854	5.86	No	No	0	9	9
9	R:R:F622	R:R:T621	7.78	No	No	0	6	9
10	R:R:I623	R:R:I626	5.89	No	No	0	9	9
11	R:R:I623	R:R:Y854	7.25	No	No	0	9	9
12	R:R:S675	R:R:Y625	8.9	No	No	0	7	8
13	R:R:C628	R:R:L672	4.76	No	No	0	9	9
14	R:R:L630	R:R:L862	4.15	No	No	0	5	7
15	R:R:F865	R:R:L630	14.61	No	No	0	7	5
16	R:R:N668	R:R:S631	7.45	No	No	0	9	9
17	R:R:L669	R:R:S632	6.01	No	No	0	8	9
18	R:R:F634	R:R:I633	6.28	No	No	0	9	9
19	R:R:F634	R:R:F865	7.5	No	No	0	9	7
20	R:R:F634	R:R:F868	10.72	No	Yes	0	9	9
21	R:R:G864	R:R:L635	5.13	No	No	0	9	9
22	R:R:F868	R:R:V637	3.93	Yes	No	0	9	4
23	R:R:F868	R:R:T638	5.19	Yes	No	1	9	9
24	R:R:C872	R:R:T638	5.07	Yes	No	1	9	9
25	R:R:L639	R:R:L665	4.15	No	No	0	9	8
26	R:R:C872	R:R:T641	5.07	Yes	No	1	9	9
27	R:R:T641	R:R:W882	6.06	No	Yes	1	9	9
28	R:R:I648	R:R:Y642	9.67	Yes	Yes	0	8	9
29	R:R:S654	R:R:Y642	3.82	No	Yes	0	9	9
30	R:R:L657	R:R:Y642	4.69	No	Yes	0	9	9
31	R:R:I658	R:R:Y642	7.25	No	Yes	0	9	9
32	R:R:I643	R:R:I658	4.42	No	No	0	7	9
33	R:R:F645	R:R:Q881	17.57	No	No	0	9	9
34	R:R:E646	R:R:R649	10.47	No	No	0	6	9
35	R:R:K647	R:R:Q881	5.42	No	No	0	9	9
36	R:R:I648	R:R:N877	5.66	Yes	No	1	8	8
37	R:R:I648	R:R:V878	4.61	Yes	Yes	1	8	9
38	R:R:I648	R:R:Q881	4.12	Yes	No	0	8	9
39	R:R:D651	R:R:S654	7.36	No	No	0	9	9
40	R:R:K655	R:R:Y652	5.97	No	Yes	5	9	8
41	R:R:Y652	R:R:Y722	5.96	Yes	No	0	8	6
42	R:R:Y652	R:R:Y726	9.93	Yes	Yes	0	8	8
43	R:R:I727	R:R:Y652	4.84	No	Yes	5	8	8
44	R:R:H710	R:R:P653	7.63	No	No	0	9	9
45	R:R:I727	R:R:K655	8.72	No	No	5	8	9
46	R:R:I656	R:R:W703	4.7	Yes	Yes	0	9	9
47	R:R:E707	R:R:I656	13.66	No	Yes	0	9	9
48	R:R:H710	R:R:I656	7.95	No	Yes	0	9	9
49	R:R:F730	R:R:I656	3.77	No	Yes	0	8	9
50	R:R:Q659	R:R:W703	12.05	No	Yes	3	7	9
51	R:R:C731	R:R:Q659	4.58	No	No	3	8	7
52	R:R:Q659	R:R:W735	4.38	No	Yes	3	7	9
53	R:R:L664	R:R:S700	7.51	No	No	0	9	7
54	R:R:L664	R:R:Q863	5.32	No	Yes	0	9	9
55	R:R:L665	R:R:L669	4.15	No	No	0	8	8
56	R:R:F696	R:R:L666	13.4	No	No	0	9	5
57	R:R:F692	R:R:I670	3.77	No	No	0	7	6
58	R:R:F696	R:R:I670	5.02	No	No	0	9	6
59	R:R:F671	R:R:L693	4.87	No	No	0	9	9
60	R:R:F671	R:R:F769	4.29	No	No	0	9	9
61	R:R:I677	R:R:L673	4.28	No	No	0	8	8
62	R:R:D674	R:R:V689	13.15	Yes	No	0	9	8
63	R:R:D674	R:R:L693	6.79	Yes	No	0	9	9
64	R:R:D674	R:R:F769	10.75	Yes	No	0	9	9
65	R:R:C686	R:R:C770	7.28	No	No	0	9	9
66	R:R:G754	R:R:I687	5.29	No	No	0	9	9
67	R:R:A690	R:R:Y753	4	No	Yes	0	9	9
68	R:R:V691	R:R:Y753	6.31	No	Yes	0	6	9
69	R:R:L693	R:R:W771	4.56	No	No	0	9	9
70	R:R:H694	R:R:L698	9	Yes	No	0	9	9
71	R:R:H694	R:R:V742	6.92	Yes	No	4	9	9
72	R:R:H694	R:R:Y753	15.24	Yes	Yes	4	9	9
73	R:R:H694	R:R:I772	5.3	Yes	No	4	9	8
74	R:R:F696	R:R:Y695	5.16	No	Yes	0	9	9
75	R:R:V699	R:R:Y695	8.83	No	Yes	3	7	9
76	R:R:W735	R:R:Y695	8.68	Yes	Yes	3	9	9
77	R:R:F701	R:R:L697	6.09	No	No	0	9	9
78	R:R:L698	R:R:Y785	4.69	No	No	0	9	9
79	R:R:V699	R:R:W735	15.94	No	Yes	3	7	9
80	R:R:P738	R:R:V699	5.3	No	No	0	9	7
81	R:R:F701	R:R:F786	15	No	No	2	9	9
82	R:R:F701	R:R:W838	14.03	No	Yes	2	9	9
83	R:R:P738	R:R:T702	8.74	No	No	0	9	9
84	R:R:T702	R:R:Y785	6.24	No	No	0	9	9
85	R:R:L706	R:R:W703	5.69	No	Yes	0	9	9
86	R:R:C731	R:R:W703	3.92	No	Yes	3	8	9
87	R:R:G734	R:R:W703	7.04	No	Yes	0	9	9
88	R:R:W703	R:R:W735	9.37	Yes	Yes	3	9	9
89	R:R:M704	R:R:W838	5.82	No	Yes	2	9	9
90	R:R:M704	R:R:Q863	4.08	No	Yes	2	9	9
91	R:R:G705	R:R:N793	5.09	No	Yes	0	8	9
92	R:R:L706	R:R:V733	7.45	No	No	0	9	4
93	R:R:E707	R:R:L833	6.63	No	No	0	9	9
94	R:R:F709	R:R:L713	4.87	No	No	0	7	5
95	R:R:F709	R:R:F730	4.29	No	No	0	7	8
96	R:R:H710	R:R:Y726	6.53	No	Yes	0	9	8
97	R:R:L834	R:R:M711	4.24	No	Yes	0	9	9
98	R:R:V716	R:R:Y712	10.09	No	No	0	9	9
99	R:R:K717	R:R:Y712	5.97	No	No	0	9	9
100	R:R:M796	R:R:Y712	7.18	Yes	No	0	9	9
101	R:R:L713	R:R:T721	7.37	No	No	0	5	7
102	R:R:L713	R:R:Y726	5.86	No	Yes	0	5	8
103	R:R:K725	R:R:R724	8.66	No	No	0	5	7
104	R:R:K729	R:R:R724	8.66	No	No	0	9	7
105	R:R:K725	R:R:L728	12.69	No	No	0	5	7
106	R:R:F730	R:R:Y726	13.41	No	Yes	0	8	8
107	R:R:V742	R:R:Y753	5.05	No	Yes	4	9	9
108	R:R:V745	R:R:Y753	3.79	No	Yes	0	8	9
109	R:R:V745	R:R:V777	4.81	No	No	0	8	7
110	R:R:N752	R:R:S749	4.47	No	No	0	8	6
111	R:R:N752	R:R:S774	11.92	No	No	0	8	7
112	R:R:I772	R:R:Y753	7.25	No	Yes	4	8	9
113	R:R:C770	R:R:I755	6.55	No	No	0	9	6
114	R:R:F778	R:R:W771	7.02	Yes	No	0	9	9
115	R:R:F778	R:R:Y779	7.22	Yes	No	0	9	9
116	R:R:F778	R:R:V782	7.87	Yes	No	0	9	9
117	R:R:F778	R:R:V783	5.24	Yes	No	0	9	9
118	R:R:F786	R:R:W838	8.02	No	Yes	2	9	9
119	R:R:F786	R:R:F842	7.5	No	No	0	9	9
120	R:R:I789	R:R:N793	4.25	No	Yes	0	7	9
121	R:R:F790	R:R:V794	7.87	No	No	0	9	2
122	R:R:F790	R:R:G839	6.02	No	No	0	9	9
123	R:R:F790	R:R:F842	10.72	No	No	0	9	9
124	R:R:L834	R:R:N793	5.49	No	Yes	0	9	9
125	R:R:M796	R:R:V799	4.56	Yes	No	0	9	9
126	R:R:F797	R:R:L801	7.31	No	No	0	9	7
127	R:R:F797	R:R:T831	3.89	No	No	0	9	8
128	R:R:F797	R:R:I836	11.3	No	No	0	9	9
129	R:R:I827	R:R:L801	4.28	No	No	0	7	7
130	R:R:R806	R:R:V802	3.92	No	No	0	9	7
131	R:R:Q803	R:R:R806	10.51	No	No	0	9	9
132	R:R:F870	R:R:G829	4.52	Yes	No	0	9	9
133	R:R:G829	R:R:Y871	4.35	No	No	0	9	8
134	R:R:F832	R:R:T831	3.89	No	No	0	6	8
135	R:R:F832	R:R:T837	5.19	No	Yes	0	6	9
136	R:R:F832	R:R:F866	21.43	No	No	0	6	9
137	R:R:L833	R:R:Y871	16.41	No	No	0	9	8
138	R:R:G835	R:R:W838	4.22	No	Yes	0	9	9
139	R:R:F840	R:R:T837	3.89	No	Yes	0	9	9
140	R:R:F859	R:R:T837	3.89	No	Yes	0	8	9
141	R:R:N860	R:R:T837	8.77	No	Yes	0	9	9
142	R:R:F856	R:R:W838	5.01	Yes	Yes	2	9	9
143	R:R:N860	R:R:W838	19.21	No	Yes	2	9	9
144	R:R:Q863	R:R:W838	4.38	Yes	Yes	2	9	9
145	R:R:F840	R:R:L855	4.87	No	No	0	9	9
146	R:R:A841	R:R:F856	8.32	No	Yes	0	9	9
147	R:R:F843	R:R:F852	9.65	No	Yes	0	9	9
148	R:R:A844	R:R:F856	4.16	No	Yes	0	9	9
149	R:R:G846	R:R:P847	4.06	No	No	0	8	8
150	R:R:N849	R:R:V848	4.43	No	No	0	8	7
151	R:R:N849	R:R:T851	4.39	No	No	6	8	5
152	R:R:F852	R:R:N849	8.46	Yes	No	6	9	8
153	R:R:F852	R:R:T851	3.89	Yes	No	6	9	5
154	R:R:F856	R:R:N860	8.46	Yes	No	2	9	9
155	R:R:F859	R:R:I858	3.77	No	No	0	8	9
156	R:R:F866	R:R:L862	4.87	No	No	0	9	7
157	R:R:I867	R:R:Q863	5.49	No	Yes	0	9	9
158	R:R:F865	R:R:I869	3.77	No	No	0	7	6
159	R:R:F866	R:R:I869	3.77	No	No	0	9	6
160	R:R:C872	R:R:F868	5.59	Yes	Yes	1	9	9
161	R:R:A873	R:R:F868	4.16	No	Yes	0	8	9
162	R:R:F868	R:R:W882	4.01	Yes	Yes	1	9	9
163	R:R:F870	R:R:I869	3.77	Yes	No	0	9	6
164	R:R:C872	R:R:W882	3.92	Yes	Yes	1	9	9
165	R:R:K875	R:R:N877	12.59	No	No	1	9	8
166	R:R:K875	R:R:V878	4.55	No	Yes	1	9	9
167	R:R:N877	R:R:V878	4.43	No	Yes	1	8	9
168	R:R:V878	R:R:W882	4.9	Yes	Yes	1	9	9
169	R:R:G864	R:R:S631	3.71	No	No	0	9	9
170	R:R:I723	R:R:Y726	3.63	No	Yes	0	6	8
171	R:R:G627	R:R:L862	3.42	No	No	0	9	7
172	R:R:C770	R:R:V689	3.42	No	No	0	9	8
173	R:R:I737	R:R:P738	3.39	No	No	0	4	9
174	R:R:L746	R:R:P750	3.28	No	No	0	8	6
175	R:R:S774	R:R:V777	3.23	No	No	0	7	7
176	R:R:A708	R:R:M796	3.22	No	Yes	0	9	9
177	R:R:C661	R:R:L635	3.17	No	No	0	9	9
178	R:R:C661	R:R:L639	3.17	No	No	0	9	9
179	R:R:C661	R:R:L657	3.17	No	No	0	9	9
180	R:R:T781	R:R:V741	3.17	No	No	0	7	7
181	L:L:?1	R:R:C628	3.16	Yes	No	0	0	9
182	R:R:A857	R:R:L620	3.15	No	No	0	7	9
183	R:R:A714	R:R:L715	3.15	No	No	0	9	8
184	R:R:A708	R:R:N793	3.13	No	Yes	0	9	9
185	R:R:I748	R:R:S749	3.1	No	No	0	5	6
186	R:R:I827	R:R:S826	3.1	No	No	0	7	9
187	R:R:I780	R:R:T781	3.04	No	No	0	9	7
188	R:R:L672	R:R:S675	3	No	No	0	9	7
189	R:R:G684	R:R:R683	3	No	No	0	6	5
190	R:R:L804	R:R:V800	2.98	No	No	0	9	9
191	R:R:I836	R:R:L834	2.85	No	No	0	9	9
192	R:R:L715	R:R:M711	2.83	No	Yes	0	8	9
193	R:R:L830	R:R:M711	2.83	No	Yes	0	8	9
194	R:R:C787	R:R:F842	2.79	No	No	0	6	9
195	R:R:L660	R:R:L664	2.77	No	No	0	9	9
196	R:R:L660	R:R:L833	2.77	No	No	0	9	9
197	R:R:A688	R:R:F685	2.77	No	No	0	8	8
198	R:R:A828	R:R:F870	2.77	No	Yes	0	5	9
199	R:R:H694	R:R:T781	2.74	Yes	No	0	9	7
200	R:R:A739	R:R:Y695	2.67	No	Yes	0	9	9
201	R:R:A663	R:R:W735	2.59	No	Yes	0	9	9
202	R:R:I658	R:R:R649	2.51	No	No	0	9	9
203	R:R:F852	R:R:L855	2.44	Yes	No	0	9	9
204	R:R:F719	R:R:N720	2.42	No	No	0	9	9
205	R:R:E876	R:R:R879	2.33	No	No	0	8	9
206	R:R:F870	R:R:R825	2.14	Yes	No	0	9	9
207	R:R:R879	R:R:W882	2	No	Yes	0	9	9
208	R:R:C686	R:R:G754	1.96	No	No	0	9	9
209	R:R:C787	R:R:G784	1.96	No	No	0	6	8
210	R:R:A739	R:R:G736	1.95	No	No	0	9	9
211	R:R:G684	R:R:T682	1.82	No	No	0	6	4
212	R:R:P750	R:R:S749	1.78	No	No	0	6	6
213	R:R:G627	R:R:I626	1.76	No	No	0	9	9
214	R:R:G629	R:R:L672	1.71	No	No	0	9	9
215	R:R:G754	R:R:N773	1.7	No	No	0	9	5
216	R:R:S636	R:R:V637	1.62	No	No	0	9	4
217	R:R:S774	R:R:V776	1.62	No	No	0	7	5
218	R:R:D751	R:R:P750	1.61	No	No	0	4	6
219	R:R:A844	R:R:M853	1.61	No	No	0	9	8
220	R:R:S743	R:R:T747	1.6	No	No	0	7	7
221	R:R:T641	R:R:V640	1.59	No	No	0	9	8
222	R:R:A662	R:R:L639	1.58	No	No	0	4	9
223	R:R:A678	R:R:D674	1.54	No	Yes	0	9	9
224	R:R:I744	R:R:V740	1.54	No	No	0	8	5
225	R:R:I798	R:R:V794	1.54	No	No	0	6	2
226	R:R:I798	R:R:V802	1.54	No	No	0	6	7
227	R:R:M796	R:R:S795	1.53	Yes	No	0	9	4
228	R:R:M711	R:R:V800	1.52	Yes	No	0	9	9
229	R:R:L673	R:R:V689	1.49	No	No	0	8	8
230	R:R:D823	R:R:S826	1.47	No	No	0	7	9
231	R:R:I723	R:R:K729	1.45	No	No	0	6	9
232	R:R:I677	R:R:L679	1.43	No	No	0	8	8
233	R:R:A644	R:R:F645	1.39	No	No	0	7	9
234	R:R:L792	R:R:N793	1.37	No	Yes	0	6	9
235	R:R:D823	R:R:L824	1.36	No	No	0	7	5
236	R:R:F719	R:R:V718	1.31	No	No	0	9	9
237	R:R:F685	R:R:T682	1.3	No	No	0	8	4
238	R:R:I807	R:R:R806	1.25	No	No	0	8	9
239	R:R:K655	R:R:R650	1.24	No	No	0	9	8
240	R:R:K880	R:R:R883	1.24	No	No	0	6	9
241	R:R:F778	R:R:N775	1.21	Yes	No	0	9	6
242	R:R:I677	R:R:W676	1.17	No	No	0	8	9
243	R:R:L679	R:R:Y680	1.17	No	No	0	8	8
244	R:R:W845	R:R:Y779	0.96	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.82125	8	2	0
2	R:R:Y642	6.3575	4	0	9
3	R:R:I648	6.015	4	1	8
4	R:R:Y652	6.675	4	5	8
5	R:R:I656	7.52	4	0	9
6	R:R:D674	8.0575	4	0	9
7	R:R:H694	7.84	5	4	9
8	R:R:Y695	6.335	4	3	9
9	R:R:W703	7.12833	6	3	9
10	R:R:M711	2.855	4	0	9
11	R:R:Y726	7.872	5	0	8
12	R:R:W735	8.192	5	3	9
13	R:R:Y753	6.94	6	4	9
14	R:R:F778	5.712	5	0	9
15	R:R:N793	3.866	5	0	9
16	R:R:M796	4.1225	4	0	9
17	R:R:T837	5.435	4	0	9
18	R:R:W838	8.295	8	2	9
19	R:R:F852	6.11	4	6	9
20	R:R:F856	9.552	5	2	9
21	R:R:Q863	4.8175	4	2	9
22	R:R:F868	5.6	6	1	9
23	R:R:F870	3.3	4	0	9
24	R:R:C872	4.9125	4	1	9
25	R:R:V878	4.6225	4	1	9
26	R:R:W882	4.178	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W838	78.2747	5.67	Yes	Yes	2	0	9
2	R:R:N860	R:R:W838	47.8822	19.21	No	Yes	2	9	9
3	R:R:N860	R:R:T837	78.6338	8.77	No	Yes	0	9	9
4	R:R:F832	R:R:T837	65.6574	5.19	No	Yes	0	6	9
5	R:R:F832	R:R:F866	58.7611	21.43	No	No	0	6	9
6	R:R:F866	R:R:L862	15.2371	4.87	No	No	0	9	7
7	R:R:G627	R:R:L862	13.7925	3.42	No	No	0	9	7
8	R:R:G627	R:R:I626	11.4829	1.76	No	No	0	9	9
9	L:L:?1	R:R:F856	32.237	21.81	Yes	Yes	2	0	9
10	R:R:F856	R:R:N860	32.1064	8.46	Yes	No	2	9	9
11	L:L:?1	R:R:C628	12.348	3.16	Yes	No	0	0	9
12	R:R:F866	R:R:I869	52.2076	3.77	No	No	0	9	6
13	R:R:F865	R:R:I869	46.8865	3.77	No	No	0	7	6
14	L:L:?1	R:R:N668	33.6571	5.46	Yes	No	0	0	9
15	R:R:N668	R:R:S631	31.9595	7.45	No	No	0	9	9
16	R:R:G864	R:R:S631	30.164	3.71	No	No	0	9	9
17	R:R:G864	R:R:L635	28.393	5.13	No	No	0	9	9
18	R:R:C661	R:R:L635	26.6792	3.17	No	No	0	9	9
19	R:R:C661	R:R:L639	11.3115	3.17	No	No	0	9	9
20	R:R:F634	R:R:F865	46.9273	7.5	No	No	0	9	7
21	R:R:F634	R:R:F868	43.4179	10.72	No	Yes	0	9	9
22	R:R:C661	R:R:L657	17.612	3.17	No	No	0	9	9
23	R:R:L657	R:R:Y642	16.2001	4.69	No	Yes	0	9	9
24	R:R:I648	R:R:Y642	18.7546	9.67	Yes	Yes	0	8	9
25	R:R:I648	R:R:V878	19.6523	4.61	Yes	Yes	1	8	9
26	R:R:V878	R:R:W882	22.0844	4.9	Yes	Yes	1	9	9
27	R:R:F868	R:R:W882	28.4828	4.01	Yes	Yes	1	9	9
28	R:R:Q863	R:R:W838	60.5484	4.38	Yes	Yes	2	9	9
29	R:R:L664	R:R:Q863	59.969	5.32	No	Yes	0	9	9
30	R:R:L660	R:R:L664	59.3324	2.77	No	No	0	9	9
31	R:R:L660	R:R:L833	59.2182	2.77	No	No	0	9	9
32	R:R:E707	R:R:L833	100	6.63	No	No	0	9	9
33	R:R:E707	R:R:I656	99.2165	13.66	No	Yes	0	9	9
34	R:R:H710	R:R:I656	25.1693	7.95	No	Yes	0	9	9
35	R:R:H710	R:R:Y726	21.962	6.53	No	Yes	0	9	8
36	R:R:Y652	R:R:Y726	17.2121	9.93	Yes	Yes	0	8	8
37	R:R:F730	R:R:I656	28.189	3.77	No	Yes	0	8	9
38	R:R:F730	R:R:Y726	21.913	13.41	No	Yes	0	8	8
39	R:R:I656	R:R:W703	65.0126	4.7	Yes	Yes	0	9	9
40	R:R:W703	R:R:W735	56.4596	9.37	Yes	Yes	3	9	9
41	R:R:W735	R:R:Y695	11.6543	8.68	Yes	Yes	3	9	9
42	L:L:?1	R:R:F671	84.8853	18.17	Yes	No	0	0	9
43	R:R:F671	R:R:L693	49.5307	4.87	No	No	0	9	9
44	R:R:D674	R:R:L693	32.8491	6.79	Yes	No	0	9	9
45	R:R:D674	R:R:V689	55.717	13.15	Yes	No	0	9	8
46	R:R:L673	R:R:V689	23.4881	1.49	No	No	0	8	8
47	R:R:I677	R:R:L673	18.828	4.28	No	No	0	8	8
48	R:R:F671	R:R:F769	33.8448	4.29	No	No	0	9	9
49	R:R:D674	R:R:F769	32.0493	10.75	Yes	No	0	9	9
50	R:R:C770	R:R:V689	28.14	3.42	No	No	0	9	8
51	R:R:C686	R:R:C770	18.828	7.28	No	No	0	9	9
52	R:R:C686	R:R:G754	14.1435	1.96	No	No	0	9	9
53	R:R:V699	R:R:W735	42.4304	15.94	No	Yes	3	7	9
54	R:R:P738	R:R:V699	42.2019	5.3	No	No	0	9	7
55	R:R:P738	R:R:T702	38.97	8.74	No	No	0	9	9
56	R:R:T702	R:R:Y785	37.3296	6.24	No	No	0	9	9
57	R:R:L698	R:R:Y785	35.6729	4.69	No	No	0	9	9
58	R:R:H694	R:R:L698	33.9998	9	Yes	No	0	9	9
59	R:R:H694	R:R:Y753	23.5779	15.24	Yes	Yes	4	9	9
60	R:R:F832	R:R:T831	56.9738	3.89	No	No	0	6	8
61	R:R:F797	R:R:T831	54.9008	3.89	No	No	0	9	8
62	R:R:F797	R:R:I836	42.9772	11.3	No	No	0	9	9
63	R:R:I836	R:R:L834	40.839	2.85	No	No	0	9	9
64	R:R:L834	R:R:N793	25.8386	5.49	No	Yes	0	9	9
65	R:R:L834	R:R:M711	13.8578	4.24	No	Yes	0	9	9
66	R:R:A708	R:R:N793	16.5674	3.13	No	Yes	0	9	9
67	R:R:A708	R:R:M796	14.2088	3.22	No	Yes	0	9	9
68	R:R:I723	R:R:Y726	17.2529	3.63	No	Yes	0	6	8
69	R:R:I723	R:R:K729	14.2088	1.45	No	No	0	6	9
70	R:R:K729	R:R:R724	10.6831	8.66	No	No	0	9	7
71	R:R:V745	R:R:Y753	18.828	3.79	No	Yes	0	8	9
72	R:R:V745	R:R:V777	17.2529	4.81	No	No	0	8	7
73	R:R:S774	R:R:V777	15.4003	3.23	No	No	0	7	7
74	R:R:N752	R:R:S774	11.6461	11.92	No	No	0	8	7
75	R:R:L693	R:R:W771	16.2654	4.56	No	No	0	9	9
76	R:R:F778	R:R:W771	14.1516	7.02	Yes	No	0	9	9
77	R:R:F786	R:R:W838	21.9048	8.02	No	Yes	2	9	9
78	R:R:F786	R:R:F842	20.4358	7.5	No	No	0	9	9
79	R:R:F790	R:R:F842	15.1963	10.72	No	No	0	9	9
80	R:R:F790	R:R:V794	11.4258	7.87	No	No	0	9	2
81	R:R:F797	R:R:L801	11.5564	7.31	No	No	0	9	7
82	R:R:F870	R:R:I869	47.2945	3.77	Yes	No	0	9	6
83	R:R:F840	R:R:T837	17.5875	3.89	No	Yes	0	9	9
84	R:R:F840	R:R:L855	15.1228	4.87	No	No	0	9	9
85	R:R:F852	R:R:L855	12.6418	2.44	Yes	No	0	9	9
86	R:R:G829	R:R:Y871	44.9523	4.35	No	No	0	9	8
87	R:R:L833	R:R:Y871	45.393	16.41	No	No	0	9	8
88	R:R:F870	R:R:G829	44.585	4.52	Yes	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:T624	10.26	2	Yes	No	0	9	0	1
L:L:?1	R:R:L667	9.64	2	Yes	No	0	9	0	1
L:L:?1	R:R:N668	5.46	2	Yes	No	0	9	0	1
L:L:?1	R:R:F671	18.17	2	Yes	No	0	9	0	1
L:L:?1	R:R:W838	5.67	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:F856	21.81	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:T861	4.4	2	Yes	No	0	8	0	1
R:R:C628	R:R:L672	4.76	0	No	No	9	9	1	2
R:R:N668	R:R:S631	7.45	0	No	No	9	9	1	2
R:R:F671	R:R:L693	4.87	0	No	No	9	9	1	2
R:R:F671	R:R:F769	4.29	0	No	No	9	9	1	2
R:R:F701	R:R:F786	15	2	No	No	9	9	2	2
R:R:F701	R:R:W838	14.03	2	No	Yes	9	9	2	1
R:R:M704	R:R:W838	5.82	2	No	Yes	9	9	2	1
R:R:M704	R:R:Q863	4.08	2	No	Yes	9	9	2	2
R:R:F786	R:R:W838	8.02	2	No	Yes	9	9	2	1
R:R:G835	R:R:W838	4.22	0	No	Yes	9	9	2	1
R:R:F856	R:R:W838	5.01	2	Yes	Yes	9	9	1	1
R:R:N860	R:R:W838	19.21	2	No	Yes	9	9	2	1
R:R:Q863	R:R:W838	4.38	2	Yes	Yes	9	9	2	1
R:R:A841	R:R:F856	8.32	0	No	Yes	9	9	2	1
R:R:A844	R:R:F856	4.16	0	No	Yes	9	9	2	1
R:R:F856	R:R:N860	8.46	2	Yes	No	9	9	1	2
L:L:?1	R:R:C628	3.16	2	Yes	No	0	9	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YKD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	230
Number of Links	244
Number of Hubs	26
Number of Links mediated by Hubs	110
Number of Communities	6
Number of Nodes involved in Communities	33
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	31904
Length Of Smallest Path	3
Average Path Length	14.269
Length of Longest Path	34
Minimum Path Strength	1.25667
Average Path Strength	7.121
Maximum Path Strength	19.99
Minimum Path Correlation	0.7
Average Path Correlation	0.912796
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	40.4734
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	30.9998
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • insulin-like growth factor receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • synapse • cell junction • G-protein beta-subunit binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • spermatid development • spermatid differentiation • sexual reproduction • cellular developmental process • spermatogenesis • reproductive process • multicellular organismal reproductive process • cell development • cellular process involved in reproduction in multicellular organism • developmental process involved in reproduction • gamete generation • male gamete generation • cell differentiation • germ cell development • cell surface receptor signaling pathway • cytosol • apical part of cell • plasma membrane region • apical plasma membrane
SCOP2	Domain Identifier	• WD40 repeat-like
SCOP2	Family Identifier	• WD40 repeat-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AND
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	AND
Name	Prasterone
Synonyms	Dehydroepiandrosterone
Identifier
Formula	C19 H28 O2
Molecular Weight	288.424
SMILES
PubChem	5881
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	6
Total Bonds	52
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8CJ12
Sequence	>8YKD_nogp_Chain_R A L T F I T Y I G C G L S S I F L S V T L V T Y I A F E K I R R D Y P S K I L I Q L C A A L L L L N L I F L L D S W I A L Y N T R G F C I A V A V F L H Y F L L V S F T W M G L E A F H M Y L A L V K V F N T Y I R K Y I L K F C I V G W G I P A V V V S I V L T I S P D N Y G I F C W I N S N V V F Y I T V V G Y F C V I F L L N V S M F I V V L V Q L C R I K K K D L R S I A G L T F L L G I T W G F A F F A W G P V N V T F M Y L F A I F N T L Q G F F I F I F Y C A A K E N V R K Q W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WUI	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	IP15	-	chim(NtGi1-Gs)/β1/γ2	3.1	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7WUI (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	IP15	-		3.1	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7WUQ	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-	Gs/β1/γ2	2.9	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7WUQ (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-		2.9	2022-04-27	doi.org/10.1038/s41586-022-04590-8
	7XKD	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-	Gs/β1/γ2	2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKD (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-		2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKE	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKE (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-		2.9	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKF	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-	Gs/β1/γ2	2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7XKF (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	β-Hydroxyandrosterone	-		2.4	2022-08-10	doi.org/10.1038/s41589-022-01084-6
	7YP7	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-	Gs/β1/γ2	3.1	2022-08-24	doi.org/10.1038/s41589-022-01084-6
	7YP7 (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	-	-		3.1	2022-08-24	doi.org/10.1038/s41589-022-01084-6
	8YKD	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-	chim(NtGi1-Gs)/β1/γ2	2.9	2025-08-13	doi.org/10.1038/s41589-025-01896-2
	8YKD (No Gprot)	B2	Adhesion	Adhesion	ADGRG2	Mus musculus	Dehydroepiandrosterone	-		2.9	2025-08-13	doi.org/10.1038/s41589-025-01896-2

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