psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S33	6.89	Yes	No	0	0	7
2	L:L:?1	R:R:F36	3.19	Yes	Yes	1	0	8
3	L:L:?1	R:R:H81	13.49	Yes	No	0	0	8
4	L:L:?1	R:R:N84	4.5	Yes	Yes	1	0	6
5	L:L:?1	R:R:G85	3.36	Yes	No	0	0	7
6	L:L:?1	R:R:A88	4.13	Yes	No	0	0	8
7	L:L:?1	R:R:Y92	6.92	Yes	Yes	1	0	8
8	L:L:?1	R:R:M115	10.2	Yes	No	1	0	8
9	L:L:?1	R:R:S118	3.94	Yes	No	1	0	7
10	L:L:?1	R:R:G119	3.36	Yes	No	0	0	7
11	L:L:?1	R:R:T184	7.73	Yes	Yes	1	0	9
12	L:L:?1	R:R:L287	4.54	Yes	No	1	0	6
13	L:L:?1	R:R:L290	4.54	Yes	No	0	0	7
14	L:L:?1	R:R:R291	5.58	Yes	Yes	1	0	8
15	L:L:?1	R:R:T294	14.5	Yes	No	1	0	9
16	L:L:?1	R:R:Q297	12.22	Yes	Yes	1	0	8
17	R:R:F31	R:R:S29	5.28	No	No	0	4	7
18	R:R:V30	R:R:V89	3.21	No	No	1	6	6
19	R:R:V30	R:R:Y92	10.09	No	Yes	1	6	8
20	R:R:F32	R:R:F36	3.22	No	Yes	1	4	8
21	R:R:F32	R:R:R291	7.48	No	Yes	1	4	8
22	R:R:F36	R:R:R291	4.28	Yes	Yes	1	8	8
23	R:R:F36	R:R:T294	6.49	Yes	No	1	8	9
24	R:R:F36	R:R:W295	6.01	Yes	No	1	8	5
25	R:R:F36	R:R:I298	3.77	Yes	No	1	8	8
26	R:R:G85	R:R:M37	5.24	No	No	0	7	7
27	R:R:G40	R:R:H81	7.94	No	No	0	9	8
28	R:R:F78	R:R:I41	7.54	No	No	0	7	6
29	R:R:I41	R:R:L82	4.28	No	No	0	6	5
30	R:R:S43	R:R:W302	8.65	No	No	0	9	6
31	R:R:D77	R:R:N44	6.73	Yes	No	0	9	9
32	R:R:N44	R:R:P301	8.15	No	No	0	9	9
33	R:R:L306	R:R:L46	4.15	No	No	0	8	5
34	R:R:A47	R:R:V74	3.39	No	Yes	0	9	8
35	R:R:I48	R:R:V74	4.61	No	Yes	0	7	8
36	R:R:I50	R:R:V311	6.14	No	No	0	8	7
37	R:R:A70	R:R:L51	4.73	No	Yes	3	8	8
38	R:R:L51	R:R:S71	7.51	Yes	No	0	8	6
39	R:R:I305	R:R:L51	7.14	No	Yes	3	8	8
40	R:R:R59	R:R:Y55	19.55	No	No	0	5	6
41	R:R:L68	R:R:Y55	8.21	No	No	0	6	6
42	R:R:Q56	R:R:R59	5.84	No	No	0	4	5
43	R:R:F58	R:R:R57	6.41	No	No	0	4	4
44	R:R:F58	R:R:L67	3.65	No	No	0	4	8
45	R:R:H143	R:R:K63	5.24	Yes	No	4	8	6
46	R:R:I147	R:R:K63	5.82	No	No	4	5	6
47	R:R:A64	R:R:L67	4.73	No	No	0	7	8
48	R:R:E132	R:R:S65	8.62	Yes	No	0	9	7
49	R:R:S65	R:R:V152	4.85	No	No	0	7	7
50	R:R:F66	R:R:L67	3.65	No	No	0	7	8
51	R:R:E132	R:R:F66	3.5	Yes	No	0	9	7
52	R:R:F66	R:R:R133	11.76	No	No	0	7	9
53	R:R:L69	R:R:M129	5.65	No	No	0	7	9
54	R:R:E132	R:R:L69	5.3	Yes	No	0	9	7
55	R:R:A70	R:R:I305	3.25	No	No	3	8	8
56	R:R:G72	R:R:L156	3.42	No	No	0	8	7
57	R:R:D77	R:R:L73	4.07	Yes	Yes	1	9	9
58	R:R:L125	R:R:L73	4.15	No	Yes	0	7	9
59	R:R:D300	R:R:L73	5.43	Yes	Yes	1	9	9
60	R:R:L73	R:R:Y304	4.69	Yes	Yes	1	9	9
61	R:R:P301	R:R:V74	3.53	No	Yes	0	9	8
62	R:R:C121	R:R:T76	6.76	Yes	No	0	7	8
63	R:R:D77	R:R:P122	3.22	Yes	No	0	9	9
64	R:R:D300	R:R:D77	5.32	Yes	Yes	1	9	9
65	R:R:G80	R:R:S118	3.71	No	No	0	8	7
66	R:R:H81	R:R:I298	5.3	No	No	0	8	8
67	R:R:C114	R:R:I83	3.27	No	No	0	4	5
68	R:R:F111	R:R:N84	4.83	Yes	Yes	1	6	6
69	R:R:M115	R:R:N84	9.82	No	Yes	1	8	6
70	R:R:N84	R:R:S118	5.96	Yes	No	1	6	7
71	R:R:F111	R:R:I87	20.09	Yes	No	0	6	6
72	R:R:F90	R:R:S94	5.28	No	No	0	5	4
73	R:R:V91	R:R:W98	11.03	No	Yes	0	7	5
74	R:R:K96	R:R:Y92	5.97	No	Yes	1	5	8
75	R:R:T184	R:R:Y92	11.24	Yes	Yes	1	9	8
76	R:R:F101	R:R:S94	5.28	No	No	0	4	4
77	R:R:K96	R:R:T184	4.5	No	Yes	1	5	9
78	R:R:E97	R:R:R100	11.63	No	No	0	4	1
79	R:R:F101	R:R:W98	16.04	No	Yes	0	4	5
80	R:R:C108	R:R:W98	5.22	No	Yes	1	9	5
81	R:R:I179	R:R:W98	5.87	No	Yes	1	5	5
82	R:R:C186	R:R:W98	3.92	No	Yes	1	9	5
83	R:R:F101	R:R:L107	6.09	No	No	0	4	5
84	R:R:D102	R:R:L107	5.43	No	No	0	4	5
85	R:R:S104	R:R:V106	3.23	No	No	0	5	3
86	R:R:C108	R:R:I179	3.27	No	No	1	9	5
87	R:R:C108	R:R:C186	7.28	No	No	1	9	9
88	R:R:D176	R:R:S109	5.89	No	No	0	3	4
89	R:R:F111	R:R:M115	3.73	Yes	No	1	6	8
90	R:R:G112	R:R:Y177	7.24	No	Yes	0	7	7
91	R:R:I113	R:R:L168	4.28	No	No	0	5	4
92	R:R:A167	R:R:V116	3.39	No	Yes	0	8	8
93	R:R:V116	R:R:Y177	6.31	Yes	Yes	1	8	7
94	R:R:F187	R:R:V116	3.93	Yes	Yes	1	8	8
95	R:R:V116	R:R:Y188	6.31	Yes	Yes	1	8	6
96	R:R:C121	R:R:F117	5.59	Yes	No	0	7	7
97	R:R:F117	R:R:V164	3.93	No	No	0	7	4
98	R:R:F205	R:R:L120	7.31	Yes	No	0	8	6
99	R:R:L120	R:R:L208	4.15	No	Yes	0	6	5
100	R:R:C121	R:R:L125	3.17	Yes	No	0	7	7
101	R:R:A163	R:R:C121	3.61	No	Yes	0	7	7
102	R:R:P122	R:R:Q297	11.05	No	Yes	0	9	8
103	R:R:L123	R:R:W262	14.81	No	Yes	0	7	9
104	R:R:L125	R:R:V159	4.47	No	No	0	7	5
105	R:R:G126	R:R:M129	3.49	No	No	0	8	9
106	R:R:S127	R:R:V215	3.23	No	No	0	7	5
107	R:R:M155	R:R:V128	4.56	No	No	0	5	7
108	R:R:M129	R:R:Y304	8.38	No	Yes	0	9	9
109	R:R:A130	R:R:S216	3.42	No	No	7	9	8
110	R:R:A130	R:R:N220	4.69	No	Yes	7	9	9
111	R:R:C219	R:R:I131	3.27	No	No	0	7	6
112	R:R:E132	R:R:H143	4.92	Yes	Yes	0	9	8
113	R:R:M247	R:R:R133	8.69	No	No	5	8	9
114	R:R:Q250	R:R:R133	11.68	No	No	5	8	9
115	R:R:C134	R:R:T138	3.38	Yes	No	0	6	7
116	R:R:C134	R:R:C219	3.64	Yes	No	0	6	7
117	R:R:C134	R:R:I222	3.27	Yes	No	0	6	4
118	R:R:C134	R:R:T223	3.38	Yes	No	0	6	8
119	R:R:G136	R:R:H143	9.53	No	Yes	0	8	8
120	R:R:T223	R:R:V137	4.76	No	No	0	8	8
121	R:R:T138	R:R:T226	4.71	No	No	0	7	6
122	R:R:F142	R:R:K139	8.69	No	No	0	4	5
123	R:R:F142	R:R:K146	4.96	No	No	0	4	4
124	R:R:H143	R:R:I147	6.63	Yes	No	4	8	5
125	R:R:S144	R:R:T145	3.2	No	No	0	6	5
126	R:R:H151	R:R:T148	9.58	No	No	0	5	7
127	R:R:K153	R:R:S149	6.12	No	No	0	5	3
128	R:R:K150	R:R:M154	11.52	No	No	0	5	3
129	R:R:M155	R:R:V152	4.56	No	No	0	5	7
130	R:R:F162	R:R:I166	11.3	No	No	6	4	6
131	R:R:F162	R:R:L208	4.87	No	Yes	6	4	5
132	R:R:F165	R:R:I166	6.28	No	No	0	3	6
133	R:R:I166	R:R:L208	4.28	No	Yes	6	6	5
134	R:R:L169	R:R:P170	4.93	No	No	1	6	9
135	R:R:L169	R:R:Y201	4.69	No	Yes	1	6	6
136	R:R:P170	R:R:Y177	9.74	No	Yes	1	9	7
137	R:R:P170	R:R:Y201	5.56	No	Yes	1	9	6
138	R:R:I171	R:R:Y177	4.84	No	Yes	0	4	7
139	R:R:G173	R:R:H174	3.18	No	No	0	7	4
140	R:R:K194	R:R:R175	7.43	Yes	Yes	2	1	8
141	R:R:D195	R:R:R175	4.76	No	Yes	0	1	8
142	R:R:E197	R:R:R175	10.47	Yes	Yes	0	2	8
143	R:R:D198	R:R:R175	7.15	Yes	Yes	2	5	8
144	R:R:Y177	R:R:Y188	8.94	Yes	Yes	1	7	6
145	R:R:K178	R:R:N189	16.79	No	Yes	0	5	6
146	R:R:Q180	R:R:W185	16.43	No	Yes	1	8	8
147	R:R:F187	R:R:Q180	3.51	Yes	No	1	8	8
148	R:R:Q180	R:R:T190	9.92	No	No	0	8	7
149	R:R:A181	R:R:E191	4.53	No	No	0	4	3
150	R:R:A181	R:R:C283	3.61	No	No	0	4	4
151	R:R:S182	R:R:T184	4.8	No	Yes	1	8	9
152	R:R:S182	R:R:W185	7.41	No	Yes	1	8	8
153	R:R:C283	R:R:S182	3.44	No	No	0	4	8
154	R:R:T184	R:R:W185	3.64	Yes	Yes	1	9	8
155	R:R:F187	R:R:W185	9.02	Yes	Yes	1	8	8
156	R:R:L290	R:R:W185	10.25	No	Yes	0	7	8
157	R:R:F187	R:R:Y188	12.38	Yes	Yes	1	8	6
158	R:R:F187	R:R:F205	4.29	Yes	Yes	1	8	8
159	R:R:F187	R:R:F265	4.29	Yes	Yes	1	8	8
160	R:R:Y188	R:R:Y201	5.96	Yes	Yes	1	6	6
161	R:R:L202	R:R:Y188	4.69	No	Yes	0	6	6
162	R:R:F205	R:R:Y188	6.19	Yes	Yes	1	8	6
163	R:R:D192	R:R:N189	13.46	Yes	Yes	2	2	6
164	R:R:K194	R:R:N189	6.99	Yes	Yes	2	1	6
165	R:R:D198	R:R:N189	13.46	Yes	Yes	2	5	6
166	R:R:E191	R:R:T190	8.47	No	No	0	3	7
167	R:R:D192	R:R:K194	20.74	Yes	Yes	2	2	1
168	R:R:D192	R:R:D198	3.99	Yes	Yes	2	2	5
169	R:R:D198	R:R:K194	8.3	Yes	Yes	2	5	1
170	R:R:E197	R:R:W196	6.54	Yes	No	0	2	1
171	R:R:F200	R:R:W196	12.03	No	No	0	5	1
172	R:R:E197	R:R:Y201	4.49	Yes	Yes	0	2	6
173	R:R:F200	R:R:Y201	4.13	No	Yes	0	5	6
174	R:R:L202	R:R:M269	5.65	No	Yes	0	6	7
175	R:R:G273	R:R:L202	3.42	No	No	0	4	6
176	R:R:L204	R:R:L208	4.15	No	Yes	0	4	5
177	R:R:F205	R:R:F265	3.22	Yes	Yes	1	8	8
178	R:R:A270	R:R:S206	3.42	No	No	0	5	7
179	R:R:F207	R:R:L211	3.65	No	No	0	4	4
180	R:R:G209	R:R:L266	5.13	No	No	0	7	7
181	R:R:L210	R:R:L266	6.92	No	No	0	5	7
182	R:R:N220	R:R:S216	4.47	Yes	No	7	9	8
183	R:R:L217	R:R:M255	4.24	No	No	0	5	8
184	R:R:C259	R:R:L217	4.76	No	No	0	5	5
185	R:R:L251	R:R:N220	4.12	No	Yes	0	8	9
186	R:R:M255	R:R:N220	7.01	No	Yes	0	8	9
187	R:R:I225	R:R:R229	3.76	No	No	0	3	4
188	R:R:H244	R:R:L227	5.14	No	No	0	8	8
189	R:R:L228	R:R:V248	5.96	No	Yes	0	5	7
190	R:R:E246	R:R:R308	4.65	No	Yes	0	7	9
191	R:R:E246	R:R:K309	12.15	No	No	0	7	7
192	R:R:M247	R:R:Q250	8.16	No	No	5	8	8
193	R:R:L251	R:R:M247	4.24	No	No	0	8	8
194	R:R:Q250	R:R:R308	18.69	No	Yes	0	8	9
195	R:R:I254	R:R:Y304	13.3	No	Yes	0	8	9
196	R:R:C256	R:R:V257	3.42	No	No	0	5	7
197	R:R:V257	R:R:V303	3.21	No	No	0	7	8
198	R:R:C261	R:R:N296	6.3	No	Yes	0	8	9
199	R:R:F265	R:R:W262	7.02	Yes	Yes	1	8	9
200	R:R:L266	R:R:W262	3.42	No	Yes	0	7	9
201	R:R:A293	R:R:W262	7.78	No	Yes	0	8	9
202	R:R:N296	R:R:W262	12.43	Yes	Yes	1	9	9
203	R:R:Q297	R:R:W262	10.95	Yes	Yes	1	8	9
204	R:R:P264	R:R:S263	3.56	No	No	0	9	5
205	R:R:F265	R:R:M269	8.71	Yes	Yes	0	8	7
206	R:R:A289	R:R:F265	4.16	No	Yes	0	7	8
207	R:R:F265	R:R:L290	3.65	Yes	No	0	8	7
208	R:R:E281	R:R:T268	7.06	No	No	0	1	5
209	R:R:L280	R:R:N271	12.36	No	No	0	2	4
210	R:R:I272	R:R:L280	17.13	No	No	0	6	2
211	R:R:N275	R:R:S279	4.47	No	No	0	1	1
212	R:R:E281	R:R:T285	16.93	No	No	0	1	2
213	R:R:L287	R:R:R291	14.58	No	Yes	1	6	8
214	R:R:I298	R:R:W295	9.4	No	No	1	8	5
215	R:R:L299	R:R:W295	5.69	No	No	0	7	5
216	R:R:N296	R:R:Q297	9.24	Yes	Yes	1	9	8
217	R:R:D300	R:R:N296	4.04	Yes	Yes	1	9	9
218	R:R:D300	R:R:Y304	5.75	Yes	Yes	1	9	9
219	R:R:L306	R:R:W302	14.81	No	No	0	8	6
220	R:R:R308	R:R:V311	3.92	Yes	No	0	9	7
221	R:R:C114	R:R:N84	3.15	No	Yes	0	4	6
222	R:R:I171	R:R:S109	3.1	No	No	0	4	4
223	R:R:I110	R:R:V106	3.07	No	No	0	5	3
224	R:R:I131	R:R:V215	3.07	No	No	0	6	5
225	R:R:I254	R:R:V303	3.07	No	No	0	8	8
226	R:R:K61	R:R:S62	3.06	No	No	0	5	7
227	R:R:K63	R:R:S149	3.06	No	No	0	6	3
228	R:R:I35	R:R:T38	3.04	No	No	0	4	5
229	R:R:I272	R:R:T268	3.04	No	No	0	6	5
230	R:R:K139	R:R:T138	3	No	No	0	5	7
231	R:R:K146	R:R:T145	3	No	No	0	4	5
232	R:R:L213	R:R:S258	3	No	No	0	8	9
233	R:R:L51	R:R:V74	2.98	Yes	Yes	0	8	8
234	R:R:L124	R:R:V159	2.98	No	No	0	5	5
235	R:R:L227	R:R:V137	2.98	No	No	0	8	8
236	R:R:L168	R:R:V164	2.98	No	No	0	4	4
237	R:R:L227	R:R:V248	2.98	No	Yes	0	8	7
238	R:R:N296	R:R:S258	2.98	Yes	No	0	9	9
239	R:R:L251	R:R:T223	2.95	No	No	0	8	8
240	R:R:I48	R:R:I75	2.94	No	No	0	7	6
241	R:R:I131	R:R:I135	2.94	No	No	0	6	5
242	R:R:I272	R:R:M269	2.92	No	Yes	0	6	7
243	R:R:I274	R:R:L203	2.85	No	No	0	3	4
244	R:R:I222	R:R:L218	2.85	No	No	0	4	3
245	R:R:E284	R:R:T282	2.82	No	No	0	1	4
246	R:R:D192	R:R:I193	2.8	Yes	No	0	2	1
247	R:R:C186	R:R:F111	2.79	No	Yes	1	9	6
248	R:R:A54	R:R:F58	2.77	No	No	0	7	4
249	R:R:L307	R:R:L312	2.77	No	No	0	6	7
250	R:R:L280	R:R:N277	2.75	No	No	0	2	1
251	R:R:E97	R:R:I99	2.73	No	No	0	4	1
252	R:R:D102	R:R:N105	2.69	No	No	0	4	1
253	R:R:A64	R:R:Y55	2.67	No	No	0	7	6
254	R:R:F78	R:R:S45	2.64	No	No	0	7	5
255	R:R:F31	R:R:I35	2.51	No	No	0	4	4
256	R:R:F79	R:R:I75	2.51	No	No	0	5	6
257	R:R:I179	R:R:R183	2.51	No	No	0	5	6
258	R:R:E197	R:R:H174	2.46	Yes	No	0	2	4
259	R:R:T286	R:R:W185	2.43	No	Yes	0	7	8
260	R:R:L307	R:R:R308	2.43	No	Yes	0	6	9
261	R:R:F78	R:R:N44	2.42	No	No	0	7	9
262	R:R:L307	R:R:W302	2.28	No	No	0	6	6
263	R:R:A289	R:R:P264	1.87	No	No	0	7	9
264	R:R:G72	R:R:S71	1.86	No	No	0	8	6
265	R:R:G158	R:R:S157	1.86	No	No	0	1	3
266	R:R:G40	R:R:V39	1.84	No	No	0	9	6
267	R:R:G224	R:R:V248	1.84	No	Yes	0	7	7
268	R:R:C121	R:R:C160	1.82	Yes	No	0	7	6
269	R:R:A212	R:R:S127	1.71	No	No	0	7	7
270	R:R:G158	R:R:L161	1.71	No	No	0	1	3
271	R:R:G273	R:R:L203	1.71	No	No	0	4	4
272	R:R:G214	R:R:L213	1.71	No	No	0	3	8
273	R:R:G214	R:R:L217	1.71	No	No	0	3	5
274	R:R:G276	R:R:N275	1.7	No	No	0	1	1
275	R:R:C283	R:R:T282	1.69	No	No	0	4	4
276	R:R:M292	R:R:P264	1.68	No	No	0	6	9
277	R:R:K139	R:R:P140	1.67	No	No	0	5	8
278	R:R:C114	R:R:I110	1.64	No	No	0	4	5
279	R:R:C261	R:R:I260	1.64	No	No	0	8	5
280	R:R:A86	R:R:M37	1.61	No	No	0	7	7
281	R:R:A221	R:R:M255	1.61	No	No	0	4	8
282	R:R:V30	R:R:V34	1.6	No	No	1	6	4
283	R:R:V34	R:R:V89	1.6	No	No	1	4	6
284	R:R:T38	R:R:V34	1.59	No	No	0	5	4
285	R:R:T38	R:R:V39	1.59	No	No	0	5	6
286	R:R:M269	R:R:S206	1.53	Yes	No	0	7	7
287	R:R:I141	R:R:T145	1.52	No	No	0	5	5
288	R:R:K150	R:R:T148	1.5	No	No	0	5	7
289	R:R:L211	R:R:V215	1.49	No	No	0	4	5
290	R:R:L252	R:R:V248	1.49	No	Yes	0	5	7
291	R:R:I48	R:R:M52	1.46	No	No	0	7	4
292	R:R:Q103	R:R:S104	1.44	No	No	0	4	5
293	R:R:L28	R:R:L287	1.38	No	No	0	4	6
294	R:R:D95	R:R:E97	1.3	No	No	0	4	4
295	R:R:F288	R:R:M292	1.24	No	No	0	4	6
296	R:R:E284	R:R:R27	1.16	No	No	0	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.81813	16	1	0
2	R:R:F36	4.49333	6	1	8
3	R:R:L51	5.59	4	3	8
4	R:R:L73	4.585	4	1	9
5	R:R:V74	3.6275	4	0	8
6	R:R:D77	4.835	4	1	9
7	R:R:N84	5.652	5	1	6
8	R:R:Y92	8.555	4	1	8
9	R:R:W98	8.416	5	1	5
10	R:R:F111	7.86	4	1	6
11	R:R:V116	4.985	4	1	8
12	R:R:C121	4.19	5	0	7
13	R:R:E132	5.585	4	0	9
14	R:R:C134	3.4175	4	0	6
15	R:R:H143	6.58	4	4	8
16	R:R:R175	7.4525	4	2	8
17	R:R:Y177	7.414	5	1	7
18	R:R:T184	6.382	5	1	9
19	R:R:W185	8.19667	6	1	8
20	R:R:F187	6.23667	6	1	8
21	R:R:Y188	7.41167	6	1	6
22	R:R:N189	12.675	4	2	6
23	R:R:D192	10.2475	4	2	2
24	R:R:K194	10.865	4	2	1
25	R:R:E197	5.99	4	0	2
26	R:R:D198	8.225	4	2	5
27	R:R:Y201	4.966	5	1	6
28	R:R:F205	5.2525	4	1	8
29	R:R:L208	4.3625	4	6	5
30	R:R:N220	5.0725	4	7	9
31	R:R:V248	3.0675	4	0	7
32	R:R:W262	9.40167	6	1	9
33	R:R:F265	5.175	6	1	8
34	R:R:M269	4.7025	4	0	7
35	R:R:R291	7.98	4	1	8
36	R:R:N296	6.998	5	1	9
37	R:R:Q297	10.865	4	1	8
38	R:R:D300	5.135	4	1	9
39	R:R:Y304	8.03	4	1	9
40	R:R:R308	7.4225	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H81	17.1967	13.49	Yes	No	0	0	8
2	R:R:G40	R:R:H81	12.0242	7.94	No	No	0	9	8
3	R:R:I35	R:R:T38	11.0708	3.04	No	No	0	4	5
4	L:L:?1	R:R:Y92	14.1515	6.92	Yes	Yes	1	0	8
5	R:R:V30	R:R:Y92	14.3152	10.09	No	Yes	1	6	8
6	R:R:V30	R:R:V34	10.2312	1.6	No	No	1	6	4
7	L:L:?1	R:R:F36	13.6535	3.19	Yes	Yes	1	0	8
8	L:L:?1	R:R:Q297	86.2682	12.22	Yes	Yes	1	0	8
9	R:R:P122	R:R:Q297	35.6386	11.05	No	Yes	0	9	8
10	R:R:D77	R:R:P122	34.7705	3.22	Yes	No	0	9	9
11	R:R:D77	R:R:N44	62.9883	6.73	Yes	No	0	9	9
12	R:R:F78	R:R:N44	14.6211	2.42	No	No	0	7	9
13	R:R:N296	R:R:Q297	62.0277	9.24	Yes	Yes	1	9	8
14	R:R:D300	R:R:N296	97.1398	4.04	Yes	Yes	1	9	9
15	R:R:D300	R:R:Y304	68.9221	5.75	Yes	Yes	1	9	9
16	R:R:M129	R:R:Y304	78.2782	8.38	No	Yes	0	9	9
17	R:R:L69	R:R:M129	75.8236	5.65	No	No	0	7	9
18	R:R:E132	R:R:L69	74.7136	5.3	Yes	No	0	9	7
19	R:R:E132	R:R:F66	59.6869	3.5	Yes	No	0	9	7
20	R:R:F66	R:R:R133	44.5322	11.76	No	No	0	7	9
21	R:R:Q250	R:R:R133	23.0167	11.68	No	No	5	8	9
22	R:R:Q250	R:R:R308	24.518	18.69	No	Yes	0	8	9
23	R:R:L307	R:R:R308	13.995	2.43	No	Yes	0	6	9
24	R:R:N44	R:R:P301	45.6635	8.15	No	No	0	9	9
25	R:R:P301	R:R:V74	42.1558	3.53	No	Yes	0	9	8
26	R:R:I48	R:R:V74	14.6211	4.61	No	Yes	0	7	8
27	R:R:L51	R:R:V74	20.804	2.98	Yes	Yes	0	8	8
28	R:R:L51	R:R:S71	10.4803	7.51	Yes	No	0	8	6
29	R:R:F66	R:R:L67	20.1138	3.65	No	No	0	7	8
30	R:R:A64	R:R:L67	11.3554	4.73	No	No	0	7	8
31	R:R:E132	R:R:H143	13.3333	4.92	Yes	Yes	0	9	8
32	R:R:D77	R:R:L73	19.2814	4.07	Yes	Yes	1	9	9
33	R:R:D300	R:R:L73	17.9224	5.43	Yes	Yes	1	9	9
34	R:R:L125	R:R:L73	30.7506	4.15	No	Yes	0	7	9
35	R:R:C121	R:R:L125	22.5329	3.17	Yes	No	0	7	7
36	L:L:?1	R:R:N84	57.3461	4.5	Yes	Yes	1	0	6
37	R:R:C114	R:R:N84	16.1295	3.15	No	Yes	0	4	6
38	R:R:F111	R:R:N84	40.5194	4.83	Yes	Yes	1	6	6
39	L:L:?1	R:R:M115	42.0776	10.2	Yes	No	1	0	8
40	R:R:F111	R:R:M115	39.6087	3.73	Yes	No	1	6	8
41	R:R:C186	R:R:F111	70.7933	2.79	No	Yes	1	9	6
42	R:R:C186	R:R:W98	50.5372	3.92	No	Yes	1	9	5
43	R:R:F101	R:R:W98	31.3269	16.04	No	Yes	0	4	5
44	R:R:F101	R:R:S94	10.4945	5.28	No	No	0	4	4
45	R:R:C108	R:R:C186	15.539	7.28	No	No	1	9	9
46	R:R:I179	R:R:W98	10.466	5.87	No	Yes	1	5	5
47	R:R:C108	R:R:I179	10.3735	3.27	No	No	1	9	5
48	R:R:F101	R:R:L107	15.7239	6.09	No	No	0	4	5
49	R:R:D102	R:R:L107	10.4945	5.43	No	No	0	4	5
50	R:R:C114	R:R:I110	10.8075	1.64	No	No	0	4	5
51	L:L:?1	R:R:T184	32.2092	7.73	Yes	Yes	1	0	9
52	R:R:T184	R:R:W185	24.5393	3.64	Yes	Yes	1	9	8
53	R:R:F187	R:R:W185	40.9463	9.02	Yes	Yes	1	8	8
54	R:R:F187	R:R:V116	20.2704	3.93	Yes	Yes	1	8	8
55	R:R:V116	R:R:Y177	14.9982	6.31	Yes	Yes	1	8	7
56	R:R:I171	R:R:Y177	21.5724	4.84	No	Yes	0	4	7
57	R:R:I171	R:R:S109	14.3935	3.1	No	No	0	4	4
58	L:L:?1	R:R:L290	64.8239	4.54	Yes	No	0	0	7
59	R:R:L290	R:R:W185	23.2871	10.25	No	Yes	0	7	8
60	R:R:F265	R:R:L290	47.1078	3.65	Yes	No	0	8	7
61	R:R:F187	R:R:F265	61.3661	4.29	Yes	Yes	1	8	8
62	R:R:F187	R:R:Y188	71.5617	12.38	Yes	Yes	1	8	6
63	R:R:Y177	R:R:Y188	25.2935	8.94	Yes	Yes	1	7	6
64	R:R:F205	R:R:F265	53.4258	3.22	Yes	Yes	1	8	8
65	R:R:F205	R:R:Y188	43.4507	6.19	Yes	Yes	1	8	6
66	R:R:C121	R:R:F117	11.3767	5.59	Yes	No	0	7	7
67	R:R:F205	R:R:L120	12.5649	7.31	Yes	No	0	8	6
68	R:R:L120	R:R:L208	10.5941	4.15	No	Yes	0	6	5
69	R:R:Q297	R:R:W262	18.4418	10.95	Yes	Yes	1	8	9
70	R:R:N296	R:R:S258	63.9132	2.98	Yes	No	0	9	9
71	R:R:L213	R:R:S258	62.4191	3	No	No	0	8	9
72	R:R:G214	R:R:L213	60.989	1.71	No	No	0	3	8
73	R:R:G214	R:R:L217	59.6941	1.71	No	No	0	3	5
74	R:R:L217	R:R:M255	57.2323	4.24	No	No	0	5	8
75	R:R:M255	R:R:N220	54.6781	7.01	No	Yes	0	8	9
76	R:R:L251	R:R:N220	51.0139	4.12	No	Yes	0	8	9
77	R:R:L251	R:R:T223	64.4184	2.95	No	No	0	8	8
78	R:R:C134	R:R:T223	47.3782	3.38	Yes	No	0	6	8
79	R:R:C134	R:R:C219	19.63	3.64	Yes	No	0	6	7
80	R:R:C219	R:R:I131	17.2252	3.27	No	No	0	7	6
81	R:R:I131	R:R:V215	12.3728	3.07	No	No	0	6	5
82	R:R:M247	R:R:R133	19.8648	8.69	No	No	5	8	9
83	R:R:L251	R:R:M247	23.1946	4.24	No	No	0	8	8
84	R:R:C134	R:R:T138	22.0206	3.38	Yes	No	0	6	7
85	R:R:T223	R:R:V137	16.9192	4.76	No	No	0	8	8
86	R:R:K139	R:R:T138	17.2252	3	No	No	0	5	7
87	R:R:F142	R:R:K139	12.3728	8.69	No	No	0	4	5
88	R:R:Y188	R:R:Y201	89.3134	5.96	Yes	Yes	1	6	6
89	R:R:E197	R:R:Y201	70.338	4.49	Yes	Yes	0	2	6
90	R:R:E197	R:R:R175	53.1839	10.47	Yes	Yes	0	2	8
91	R:R:K194	R:R:R175	22.2199	7.43	Yes	Yes	2	1	8
92	R:R:D198	R:R:R175	22.227	7.15	Yes	Yes	2	5	8
93	R:R:C283	R:R:S182	11.3483	3.44	No	No	0	4	8
94	R:R:F265	R:R:M269	25.2366	8.71	Yes	Yes	0	8	7
95	R:R:L227	R:R:V137	14.799	2.98	No	No	0	8	8
96	R:R:A289	R:R:F265	11.9104	4.16	No	Yes	0	7	8
97	R:R:I272	R:R:M269	14.984	2.92	No	Yes	0	6	7
98	R:R:I179	R:R:R183	10.4376	2.51	No	No	0	5	6
99	R:R:F265	R:R:W262	100	7.02	Yes	Yes	1	8	9
100	R:R:N296	R:R:W262	86.2469	12.43	Yes	Yes	1	9	9
101	R:R:L73	R:R:Y304	16.0157	4.69	Yes	Yes	1	9	9
102	R:R:D300	R:R:D77	29.1213	5.32	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S33	6.89	1	Yes	No	0	7	0	1
L:L:?1	R:R:F36	3.19	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:H81	13.49	1	Yes	No	0	8	0	1
L:L:?1	R:R:N84	4.5	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:G85	3.36	1	Yes	No	0	7	0	1
L:L:?1	R:R:A88	4.13	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y92	6.92	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M115	10.2	1	Yes	No	0	8	0	1
L:L:?1	R:R:S118	3.94	1	Yes	No	0	7	0	1
L:L:?1	R:R:G119	3.36	1	Yes	No	0	7	0	1
L:L:?1	R:R:T184	7.73	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:L287	4.54	1	Yes	No	0	6	0	1
L:L:?1	R:R:L290	4.54	1	Yes	No	0	7	0	1
L:L:?1	R:R:R291	5.58	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T294	14.5	1	Yes	No	0	9	0	1
L:L:?1	R:R:Q297	12.22	1	Yes	Yes	0	8	0	1
R:R:V30	R:R:Y92	10.09	1	No	Yes	6	8	2	1
R:R:F32	R:R:F36	3.22	1	No	Yes	4	8	2	1
R:R:F32	R:R:R291	7.48	1	No	Yes	4	8	2	1
R:R:F36	R:R:R291	4.28	1	Yes	Yes	8	8	1	1
R:R:F36	R:R:T294	6.49	1	Yes	No	8	9	1	1
R:R:F36	R:R:W295	6.01	1	Yes	No	8	5	1	2
R:R:F36	R:R:I298	3.77	1	Yes	No	8	8	1	2
R:R:G85	R:R:M37	5.24	0	No	No	7	7	1	2
R:R:G40	R:R:H81	7.94	0	No	No	9	8	2	1
R:R:G80	R:R:S118	3.71	0	No	No	8	7	2	1
R:R:H81	R:R:I298	5.3	0	No	No	8	8	1	2
R:R:F111	R:R:N84	4.83	1	Yes	Yes	6	6	2	1
R:R:M115	R:R:N84	9.82	1	No	Yes	8	6	1	1
R:R:N84	R:R:S118	5.96	1	Yes	No	6	7	1	1
R:R:K96	R:R:Y92	5.97	1	No	Yes	5	8	2	1
R:R:T184	R:R:Y92	11.24	1	Yes	Yes	9	8	1	1
R:R:K96	R:R:T184	4.5	1	No	Yes	5	9	2	1
R:R:F111	R:R:M115	3.73	1	Yes	No	6	8	2	1
R:R:P122	R:R:Q297	11.05	0	No	Yes	9	8	2	1
R:R:S182	R:R:T184	4.8	1	No	Yes	8	9	2	1
R:R:S182	R:R:W185	7.41	1	No	Yes	8	8	2	2
R:R:T184	R:R:W185	3.64	1	Yes	Yes	9	8	1	2
R:R:L290	R:R:W185	10.25	0	No	Yes	7	8	1	2
R:R:F265	R:R:W262	7.02	1	Yes	Yes	8	9	2	2
R:R:N296	R:R:W262	12.43	1	Yes	Yes	9	9	2	2
R:R:Q297	R:R:W262	10.95	1	Yes	Yes	8	9	1	2
R:R:F265	R:R:L290	3.65	1	Yes	No	8	7	2	1
R:R:L287	R:R:R291	14.58	1	No	Yes	6	8	1	1
R:R:I298	R:R:W295	9.4	1	No	No	8	5	2	2
R:R:N296	R:R:Q297	9.24	1	Yes	Yes	9	8	2	1
R:R:C114	R:R:N84	3.15	0	No	Yes	4	6	2	1
R:R:L28	R:R:L287	1.38	0	No	No	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IQ4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	260
Number of Links	296
Number of Hubs	40
Number of Links mediated by Hubs	147
Number of Communities	7
Number of Nodes involved in Communities	61
Number of Links involved in Communities	88

Path Summary
Number Of Nodes in MetaPath	103
Number Of Links MetaPath	102
Number of Shortest Paths	53214
Length Of Smallest Path	3
Average Path Length	12.2494
Length of Longest Path	26
Minimum Path Strength	1.46
Average Path Strength	6.01206
Maximum Path Strength	15.125
Minimum Path Correlation	0.7
Average Path Correlation	0.909631
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	47.7852
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.0195
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • defense response • response to stress • inflammatory response • response to ketone • response to prostaglandin • response to lipid • cellular response to prostaglandin D stimulus • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to prostaglandin D • response to chemical • cellular response to lipid • cellular response to ketone • cellular response to hormone stimulus • multi-multicellular organism process • multicellular organismal process • reproductive process • parturition • multi-organism reproductive process • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to estradiol • cellular anatomical structure • extracellular region • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to peptide hormone • cellular response to peptide hormone stimulus • response to nitrogen compound • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin E stimulus • response to prostaglandin E • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	87Q
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	87Q
Name	Carboprost
Synonyms	(e,z)-(1r,2r,3r,5s)-7-(3,5-dihydroxy-2-((3s)-(3-hydroxy-3-methyl-1-octenyl))cyclopentyl)-5-heptenoic acid
Identifier
Formula	C21 H36 O5
Molecular Weight	368.508
SMILES
PubChem	5281075
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	5
Total Bonds	62
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43088
Sequence	>8IQ4_nogp_Chain_R R L S V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q K S K A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D K E W I R F D Q S N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K P I F H S T K I T S K H V K M M L S G V C L F A V F I A L L P I L G H R D Y K I Q A S R T W C F Y N T E D I K D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N G N H S L E T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A V L K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IUK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.67	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.67	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.78	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.78	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-		3.14	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IQ4	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8IQ4 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-		2.7	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8IQ6	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.4	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8IQ6 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		3.4	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8XJK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-		2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.77	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.77	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.85	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.85	2024-02-28	doi.org/10.1016/j.celrep.2024.113893

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