psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S33	5.57	Yes	No	0	0	7
2	L:L:?1	R:R:H81	11.13	Yes	Yes	1	0	8
3	L:L:?1	R:R:A88	3.9	Yes	No	0	0	8
4	L:L:?1	R:R:Y92	7.25	Yes	Yes	1	0	8
5	L:L:?1	R:R:M115	10.49	Yes	No	0	0	8
6	L:L:?1	R:R:T184	6.38	Yes	Yes	1	0	9
7	L:L:?1	R:R:W185	5.63	Yes	Yes	1	0	8
8	L:L:?1	R:R:W262	8.45	Yes	Yes	1	0	9
9	L:L:?1	R:R:F265	6.02	Yes	Yes	0	0	8
10	L:L:?1	R:R:L290	7.7	Yes	No	1	0	7
11	L:L:?1	R:R:T294	4.56	Yes	No	0	0	9
12	L:L:?1	R:R:Q297	7.41	Yes	Yes	1	0	8
13	R:R:E284	R:R:R27	25.59	No	No	0	1	2
14	R:R:L28	R:R:Y92	4.69	No	Yes	0	4	8
15	R:R:V30	R:R:Y92	11.36	No	Yes	0	6	8
16	R:R:F32	R:R:R291	23.52	No	No	0	4	8
17	R:R:F36	R:R:T294	3.89	No	No	0	8	9
18	R:R:F36	R:R:W295	14.03	No	No	0	8	5
19	R:R:I41	R:R:M37	4.37	No	No	0	6	7
20	R:R:G85	R:R:M37	5.24	No	No	0	7	7
21	R:R:G40	R:R:H81	7.94	No	Yes	1	9	8
22	R:R:G40	R:R:I298	5.29	No	Yes	1	9	8
23	R:R:F78	R:R:I41	5.02	Yes	No	0	7	6
24	R:R:S43	R:R:W302	8.65	No	No	0	9	6
25	R:R:N44	R:R:V74	5.91	No	No	0	9	8
26	R:R:D77	R:R:N44	6.73	Yes	No	0	9	9
27	R:R:N44	R:R:P301	13.03	No	No	0	9	9
28	R:R:L306	R:R:L46	4.15	No	No	0	8	5
29	R:R:I48	R:R:M52	4.37	Yes	No	0	7	4
30	R:R:I48	R:R:V74	4.61	Yes	No	0	7	8
31	R:R:F78	R:R:I48	3.77	Yes	Yes	0	7	7
32	R:R:L51	R:R:S71	7.51	No	No	0	8	6
33	R:R:I305	R:R:L51	7.14	No	No	0	8	8
34	R:R:R59	R:R:Y55	14.4	No	No	0	5	6
35	R:R:L68	R:R:Y55	11.72	No	No	0	6	6
36	R:R:F58	R:R:R57	7.48	No	No	0	4	4
37	R:R:K63	R:R:S65	6.12	Yes	Yes	2	6	7
38	R:R:H143	R:R:K63	9.17	Yes	Yes	2	8	6
39	R:R:I147	R:R:K63	4.36	No	Yes	2	5	6
40	R:R:K63	R:R:S149	6.12	Yes	No	0	6	3
41	R:R:A64	R:R:L67	4.73	No	Yes	0	7	8
42	R:R:E132	R:R:S65	10.06	Yes	Yes	2	9	7
43	R:R:H143	R:R:S65	4.18	Yes	Yes	2	8	7
44	R:R:S65	R:R:V152	4.85	Yes	No	0	7	7
45	R:R:E132	R:R:F66	4.66	Yes	No	2	9	7
46	R:R:F66	R:R:R133	14.97	No	Yes	2	7	9
47	R:R:L69	R:R:M129	5.65	Yes	Yes	0	7	9
48	R:R:E132	R:R:L69	5.3	Yes	Yes	0	9	7
49	R:R:L69	R:R:V152	4.47	Yes	No	0	7	7
50	R:R:L156	R:R:L69	4.15	No	Yes	0	7	7
51	R:R:D77	R:R:L73	9.5	Yes	Yes	1	9	9
52	R:R:L125	R:R:L73	4.15	No	Yes	0	7	9
53	R:R:L73	R:R:M129	5.65	Yes	Yes	1	9	9
54	R:R:D300	R:R:L73	6.79	Yes	Yes	1	9	9
55	R:R:L73	R:R:Y304	4.69	Yes	Yes	1	9	9
56	R:R:C121	R:R:T76	6.76	Yes	No	0	7	8
57	R:R:D77	R:R:P122	6.44	Yes	No	1	9	9
58	R:R:D77	R:R:Q297	9.14	Yes	Yes	1	9	8
59	R:R:D300	R:R:D77	5.32	Yes	Yes	1	9	9
60	R:R:F78	R:R:F79	4.29	Yes	No	0	7	5
61	R:R:H81	R:R:Q297	4.95	Yes	Yes	1	8	8
62	R:R:H81	R:R:I298	6.63	Yes	Yes	1	8	8
63	R:R:C114	R:R:N84	4.72	No	No	0	4	6
64	R:R:M115	R:R:N84	8.41	No	No	0	8	6
65	R:R:N84	R:R:S118	8.94	No	No	0	6	7
66	R:R:F111	R:R:I87	15.07	No	No	0	6	6
67	R:R:F90	R:R:S94	7.93	No	No	0	5	4
68	R:R:V91	R:R:W98	9.81	No	Yes	0	7	5
69	R:R:K96	R:R:Y92	4.78	No	Yes	1	5	8
70	R:R:T184	R:R:Y92	13.73	Yes	Yes	1	9	8
71	R:R:K96	R:R:T184	4.5	No	Yes	1	5	9
72	R:R:E97	R:R:R100	10.47	No	No	4	4	1
73	R:R:E97	R:R:F101	5.83	No	No	4	4	4
74	R:R:D102	R:R:W98	4.47	No	Yes	0	4	5
75	R:R:I179	R:R:W98	16.44	No	Yes	0	5	5
76	R:R:R183	R:R:W98	11	No	Yes	0	6	5
77	R:R:C186	R:R:W98	3.92	No	Yes	0	9	5
78	R:R:F101	R:R:R100	7.48	No	No	4	4	1
79	R:R:D102	R:R:L107	6.79	No	No	0	4	5
80	R:R:S104	R:R:V106	4.85	No	No	0	5	3
81	R:R:C108	R:R:C186	7.28	No	No	0	9	9
82	R:R:D176	R:R:S109	4.42	No	No	0	3	4
83	R:R:F111	R:R:M115	4.98	No	No	0	6	8
84	R:R:C186	R:R:F111	6.98	No	No	0	9	6
85	R:R:G112	R:R:Y177	10.14	No	Yes	0	7	7
86	R:R:I113	R:R:L168	4.28	No	No	0	5	4
87	R:R:I113	R:R:I171	4.42	No	No	0	5	4
88	R:R:I113	R:R:Y177	4.84	No	Yes	0	5	7
89	R:R:V116	R:R:Y177	5.05	No	Yes	1	8	7
90	R:R:V116	R:R:Y188	5.05	No	Yes	1	8	6
91	R:R:C121	R:R:F117	6.98	Yes	No	0	7	7
92	R:R:F117	R:R:V164	3.93	No	No	0	7	4
93	R:R:I166	R:R:L120	4.28	Yes	No	0	6	6
94	R:R:P122	R:R:Q297	9.47	No	Yes	1	9	8
95	R:R:L123	R:R:W262	21.64	No	Yes	0	7	9
96	R:R:L125	R:R:V159	4.47	No	No	0	7	5
97	R:R:S127	R:R:V215	4.85	No	No	0	7	5
98	R:R:M129	R:R:Y304	8.38	Yes	Yes	1	9	9
99	R:R:A130	R:R:N220	4.69	No	Yes	0	9	9
100	R:R:E132	R:R:R133	5.82	Yes	Yes	2	9	9
101	R:R:E132	R:R:H143	6.15	Yes	Yes	2	9	8
102	R:R:M247	R:R:R133	8.69	No	Yes	2	8	9
103	R:R:Q250	R:R:R133	9.35	No	Yes	2	8	9
104	R:R:H143	R:R:I135	3.98	Yes	No	0	8	5
105	R:R:G136	R:R:H143	7.94	No	Yes	0	8	8
106	R:R:T223	R:R:V137	4.76	Yes	No	0	8	8
107	R:R:T138	R:R:T226	4.71	No	No	0	7	6
108	R:R:F142	R:R:K146	8.69	No	No	0	4	4
109	R:R:H143	R:R:I147	5.3	Yes	No	2	8	5
110	R:R:K146	R:R:T145	4.5	No	No	0	4	5
111	R:R:H151	R:R:T148	8.21	No	No	0	5	7
112	R:R:F162	R:R:I166	7.54	No	Yes	0	4	6
113	R:R:F165	R:R:I166	3.77	No	Yes	0	3	6
114	R:R:I166	R:R:L208	4.28	Yes	No	0	6	5
115	R:R:P170	R:R:Y177	12.52	Yes	Yes	1	9	7
116	R:R:P170	R:R:Y188	5.56	Yes	Yes	1	9	6
117	R:R:P170	R:R:Y201	5.56	Yes	Yes	1	9	6
118	R:R:D195	R:R:R175	8.34	No	No	1	1	8
119	R:R:E197	R:R:R175	18.61	No	No	1	2	8
120	R:R:R175	R:R:Y201	4.12	No	Yes	1	8	6
121	R:R:Y177	R:R:Y188	6.95	Yes	Yes	1	7	6
122	R:R:I179	R:R:K178	8.72	No	No	0	5	5
123	R:R:K178	R:R:N189	4.2	No	No	0	5	6
124	R:R:Q180	R:R:W185	21.9	No	Yes	1	8	8
125	R:R:F187	R:R:Q180	4.68	Yes	No	1	8	8
126	R:R:Q180	R:R:T190	7.09	No	Yes	0	8	7
127	R:R:L287	R:R:S182	6.01	No	No	0	6	8
128	R:R:T184	R:R:W185	4.85	Yes	Yes	1	9	8
129	R:R:F187	R:R:W185	7.02	Yes	Yes	1	8	8
130	R:R:L290	R:R:W185	6.83	No	Yes	1	7	8
131	R:R:F187	R:R:Y188	13.41	Yes	Yes	1	8	6
132	R:R:F187	R:R:F205	9.65	Yes	No	1	8	8
133	R:R:F187	R:R:F265	4.29	Yes	Yes	0	8	8
134	R:R:Y188	R:R:Y201	7.94	Yes	Yes	1	6	6
135	R:R:L202	R:R:Y188	4.69	No	Yes	0	6	6
136	R:R:F205	R:R:Y188	7.22	No	Yes	1	8	6
137	R:R:D198	R:R:N189	13.46	No	No	0	5	6
138	R:R:E191	R:R:T190	9.88	No	Yes	0	3	7
139	R:R:L202	R:R:T190	4.42	No	Yes	0	6	7
140	R:R:I272	R:R:T190	6.08	No	Yes	0	6	7
141	R:R:D198	R:R:I193	9.8	No	No	0	5	1
142	R:R:I193	R:R:R199	5.01	No	No	0	1	3
143	R:R:D195	R:R:W196	5.58	No	No	1	1	1
144	R:R:D195	R:R:E197	7.8	No	No	1	1	2
145	R:R:E197	R:R:W196	16.36	No	No	1	2	1
146	R:R:F200	R:R:Y201	5.16	No	Yes	0	5	6
147	R:R:F200	R:R:L204	6.09	No	No	0	5	4
148	R:R:L204	R:R:L208	4.15	No	No	0	4	5
149	R:R:G209	R:R:L266	5.13	No	No	0	7	7
150	R:R:L210	R:R:L266	6.92	No	No	0	5	7
151	R:R:N220	R:R:S216	4.47	Yes	No	0	9	8
152	R:R:L217	R:R:M255	4.24	No	No	0	5	8
153	R:R:C259	R:R:L217	4.76	No	No	0	5	5
154	R:R:L251	R:R:N220	4.12	No	Yes	0	8	9
155	R:R:M255	R:R:N220	5.61	No	Yes	0	8	9
156	R:R:R229	R:R:T226	3.88	No	No	0	4	6
157	R:R:H244	R:R:L227	5.14	No	No	0	8	8
158	R:R:L228	R:R:V248	4.47	No	No	0	5	7
159	R:R:R229	R:R:V230	3.92	No	No	0	4	7
160	R:R:H244	R:R:V230	4.15	No	No	0	8	7
161	R:R:H244	R:R:K231	10.48	No	No	0	8	6
162	R:R:H243	R:R:S242	5.58	No	No	0	5	6
163	R:R:E246	R:R:R308	6.98	No	No	0	7	9
164	R:R:E246	R:R:K309	10.8	No	No	0	7	7
165	R:R:M247	R:R:Q250	5.44	No	No	2	8	8
166	R:R:L251	R:R:M247	5.65	No	No	0	8	8
167	R:R:Q250	R:R:R308	22.2	No	No	0	8	9
168	R:R:I254	R:R:Y304	13.3	No	Yes	0	8	9
169	R:R:L299	R:R:V257	4.47	No	No	0	7	7
170	R:R:V257	R:R:V303	4.81	No	No	0	7	8
171	R:R:C261	R:R:N296	4.72	No	Yes	0	8	9
172	R:R:L266	R:R:W262	5.69	No	Yes	0	7	9
173	R:R:A293	R:R:W262	10.37	No	Yes	0	8	9
174	R:R:N296	R:R:W262	10.17	Yes	Yes	1	9	9
175	R:R:Q297	R:R:W262	7.67	Yes	Yes	1	8	9
176	R:R:F265	R:R:M269	8.71	Yes	No	0	8	7
177	R:R:E281	R:R:T268	14.11	Yes	No	0	1	5
178	R:R:N271	R:R:N275	6.81	No	No	3	4	1
179	R:R:N271	R:R:S279	8.94	No	No	3	4	1
180	R:R:E281	R:R:N271	13.15	Yes	No	3	1	4
181	R:R:E281	R:R:I272	6.83	Yes	No	0	1	6
182	R:R:I274	R:R:N275	4.25	No	No	0	3	1
183	R:R:N275	R:R:S279	5.96	No	No	3	1	1
184	R:R:E281	R:R:S279	4.31	Yes	No	3	1	1
185	R:R:T282	R:R:T285	4.71	No	No	0	4	2
186	R:R:L287	R:R:R291	7.29	No	No	0	6	8
187	R:R:F288	R:R:M292	7.46	No	No	0	4	6
188	R:R:I298	R:R:W295	9.4	Yes	No	0	8	5
189	R:R:L299	R:R:W295	4.56	No	No	0	7	5
190	R:R:N296	R:R:Q297	6.6	Yes	Yes	1	9	8
191	R:R:D300	R:R:N296	8.08	Yes	Yes	1	9	9
192	R:R:D300	R:R:Y304	5.75	Yes	Yes	1	9	9
193	R:R:L306	R:R:W302	18.22	No	No	0	8	6
194	R:R:L307	R:R:W302	5.69	No	No	0	6	6
195	L:L:?1	R:R:R291	3.76	Yes	No	0	0	8
196	R:R:F142	R:R:K139	3.72	No	No	0	4	5
197	R:R:F232	R:R:K231	3.72	No	No	0	5	6
198	R:R:G80	R:R:S118	3.71	No	No	0	8	7
199	R:R:F58	R:R:L67	3.65	No	Yes	0	4	8
200	R:R:F66	R:R:L67	3.65	No	Yes	0	7	8
201	R:R:A163	R:R:C121	3.61	No	Yes	0	7	7
202	R:R:A181	R:R:C283	3.61	No	No	0	4	4
203	R:R:P301	R:R:S43	3.56	No	No	0	9	9
204	R:R:G276	R:R:I193	3.53	No	No	0	1	1
205	R:R:G72	R:R:L156	3.42	No	No	0	8	7
206	R:R:G273	R:R:L202	3.42	No	No	0	4	6
207	R:R:G273	R:R:L203	3.42	No	No	0	4	4
208	R:R:A270	R:R:S206	3.42	No	No	0	5	7
209	R:R:A47	R:R:V74	3.39	No	No	0	9	8
210	R:R:A167	R:R:V116	3.39	No	No	0	8	8
211	R:R:C134	R:R:T138	3.38	Yes	No	0	6	7
212	R:R:C134	R:R:T223	3.38	Yes	Yes	0	6	8
213	R:R:M292	R:R:P264	3.35	No	No	0	6	9
214	R:R:L169	R:R:P170	3.28	No	Yes	0	6	9
215	R:R:C114	R:R:I83	3.27	No	No	0	4	5
216	R:R:C219	R:R:I131	3.27	No	No	0	7	6
217	R:R:C134	R:R:I222	3.27	Yes	No	0	6	4
218	R:R:A47	R:R:I305	3.25	No	No	0	9	8
219	L:L:?1	R:R:G119	3.17	Yes	No	0	0	7
220	R:R:C121	R:R:L125	3.17	Yes	No	0	7	7
221	R:R:A70	R:R:L51	3.15	No	No	0	8	8
222	R:R:I171	R:R:S109	3.1	No	No	0	4	4
223	R:R:I298	R:R:V39	3.07	Yes	No	0	8	6
224	R:R:I110	R:R:V106	3.07	No	No	0	5	3
225	R:R:I131	R:R:V215	3.07	No	No	0	6	5
226	R:R:I141	R:R:T145	3.04	No	No	0	5	5
227	R:R:L42	R:R:S45	3	No	No	0	4	5
228	R:R:K139	R:R:T138	3	No	No	0	5	7
229	R:R:L203	R:R:S206	3	No	No	0	4	7
230	R:R:L213	R:R:S258	3	No	No	0	8	9
231	R:R:L68	R:R:V152	2.98	No	No	0	6	7
232	R:R:L69	R:R:V128	2.98	Yes	No	0	7	7
233	R:R:L124	R:R:V159	2.98	No	No	0	5	5
234	R:R:L211	R:R:V215	2.98	No	No	0	4	5
235	R:R:L227	R:R:V248	2.98	No	No	0	8	7
236	R:R:N296	R:R:S258	2.98	Yes	No	0	9	9
237	R:R:L315	R:R:V311	2.98	No	No	0	4	7
238	R:R:L42	R:R:T38	2.95	No	No	0	4	5
239	R:R:L251	R:R:T223	2.95	No	Yes	0	8	8
240	R:R:I48	R:R:I75	2.94	Yes	No	0	7	6
241	R:R:I41	R:R:L82	2.85	No	No	0	6	5
242	R:R:I50	R:R:L46	2.85	No	No	0	8	5
243	R:R:I222	R:R:L218	2.85	No	No	0	4	3
244	R:R:E281	R:R:T285	2.82	Yes	No	0	1	2
245	R:R:E281	R:R:T286	2.82	Yes	No	0	1	7
246	R:R:L315	R:R:L46	2.77	No	No	0	4	5
247	R:R:A289	R:R:F265	2.77	No	Yes	0	7	8
248	R:R:F32	R:R:S29	2.64	No	No	0	4	7
249	R:R:F78	R:R:S45	2.64	Yes	No	0	7	5
250	R:R:F90	R:R:L107	2.44	No	No	0	5	5
251	R:R:F207	R:R:L211	2.44	No	No	0	4	4
252	R:R:A289	R:R:P264	1.87	No	No	0	7	9
253	R:R:C121	R:R:C160	1.82	Yes	No	0	7	6
254	R:R:C134	R:R:C219	1.82	Yes	No	0	6	7
255	R:R:G224	R:R:T223	1.82	No	Yes	0	7	8
256	R:R:P264	R:R:S263	1.78	No	No	0	9	5
257	R:R:G126	R:R:M129	1.75	No	Yes	0	8	9
258	R:R:C283	R:R:S182	1.72	No	No	0	4	8
259	R:R:A212	R:R:S127	1.71	No	No	0	7	7
260	R:R:G214	R:R:L213	1.71	No	No	0	3	8
261	R:R:A253	R:R:V303	1.7	No	No	0	5	8
262	R:R:K139	R:R:P140	1.67	No	No	0	5	8
263	R:R:C114	R:R:I110	1.64	No	No	0	4	5
264	R:R:S33	R:R:V89	1.62	No	No	0	7	6
265	R:R:A221	R:R:M255	1.61	No	No	0	4	8
266	R:R:V30	R:R:V34	1.6	No	No	0	6	4
267	R:R:V34	R:R:V89	1.6	No	No	0	4	6
268	R:R:S144	R:R:T145	1.6	No	No	0	6	5
269	R:R:G173	R:R:H174	1.59	No	No	0	7	4
270	R:R:A54	R:R:L67	1.58	No	Yes	0	7	8
271	R:R:C108	R:R:N105	1.57	No	No	0	9	1
272	R:R:I35	R:R:V39	1.54	No	No	0	4	6
273	R:R:K150	R:R:T148	1.5	No	No	0	5	7
274	R:R:L252	R:R:V248	1.49	No	No	0	5	7
275	R:R:G173	R:R:Y201	1.45	No	Yes	0	7	6
276	R:R:K153	R:R:L68	1.41	No	No	0	5	6
277	R:R:E284	R:R:T282	1.41	No	No	0	1	4
278	R:R:E97	R:R:I99	1.37	No	No	0	4	1
279	R:R:K53	R:R:Q56	1.36	No	No	0	4	4
280	R:R:K317	R:R:Q321	1.36	No	No	0	4	3
281	R:R:H151	R:R:I147	1.33	No	No	0	5	5
282	R:R:F101	R:R:S94	1.32	No	No	0	4	4
283	R:R:N26	R:R:R27	1.21	No	No	0	3	2
284	R:R:Q60	R:R:R59	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.53	14	1	0
2	R:R:I48	3.9225	4	0	7
3	R:R:K63	6.4425	4	2	6
4	R:R:S65	6.3025	4	2	7
5	R:R:L67	3.4025	4	0	8
6	R:R:L69	4.51	5	0	7
7	R:R:L73	6.156	5	1	9
8	R:R:D77	7.426	5	1	9
9	R:R:F78	3.93	4	0	7
10	R:R:H81	7.6625	4	1	8
11	R:R:Y92	8.362	5	1	8
12	R:R:W98	9.128	5	0	5
13	R:R:C121	4.468	5	0	7
14	R:R:M129	5.3575	4	1	9
15	R:R:E132	6.398	5	2	9
16	R:R:R133	9.7075	4	2	9
17	R:R:C134	2.9625	4	0	6
18	R:R:H143	6.12	6	2	8
19	R:R:I166	4.9675	4	0	6
20	R:R:P170	6.73	4	1	9
21	R:R:Y177	7.9	5	1	7
22	R:R:T184	7.365	4	1	9
23	R:R:W185	9.246	5	1	8
24	R:R:F187	7.81	5	1	8
25	R:R:Y188	7.26	7	1	6
26	R:R:T190	6.8675	4	0	7
27	R:R:Y201	4.846	5	1	6
28	R:R:N220	4.7225	4	0	9
29	R:R:T223	3.2275	4	0	8
30	R:R:W262	10.665	6	1	9
31	R:R:F265	5.4475	4	0	8
32	R:R:E281	7.34	6	3	1
33	R:R:N296	6.51	5	1	9
34	R:R:Q297	7.54	6	1	8
35	R:R:I298	6.0975	4	1	8
36	R:R:D300	6.485	4	1	9
37	R:R:Y304	8.03	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W185	58.4414	5.63	Yes	Yes	1	0	8
2	R:R:Q180	R:R:W185	24.1018	21.9	No	Yes	1	8	8
3	R:R:Q180	R:R:T190	23.8435	7.09	No	Yes	0	8	7
4	R:R:I272	R:R:T190	18.9686	6.08	No	Yes	0	6	7
5	R:R:E281	R:R:I272	17.763	6.83	Yes	No	0	1	6
6	L:L:?1	R:R:R291	10.1899	3.76	Yes	No	0	0	8
7	R:R:H81	R:R:I298	11.4194	6.63	Yes	Yes	1	8	8
8	L:L:?1	R:R:Q297	96.7182	7.41	Yes	Yes	1	0	8
9	R:R:D77	R:R:Q297	100	9.14	Yes	Yes	1	9	8
10	R:R:D77	R:R:N44	36.8033	6.73	Yes	No	0	9	9
11	R:R:N44	R:R:V74	24.7094	5.91	No	No	0	9	8
12	R:R:I48	R:R:V74	16.8158	4.61	Yes	No	0	7	8
13	R:R:F78	R:R:I48	12.7398	3.77	Yes	Yes	0	7	7
14	R:R:N44	R:R:P301	12.4432	13.03	No	No	0	9	9
15	R:R:P301	R:R:S43	11.0654	3.56	No	No	0	9	9
16	R:R:D77	R:R:L73	86.4182	9.5	Yes	Yes	1	9	9
17	R:R:L73	R:R:M129	83.2512	5.65	Yes	Yes	1	9	9
18	R:R:L69	R:R:M129	86.9445	5.65	Yes	Yes	0	7	9
19	R:R:L69	R:R:V152	11.6251	4.47	Yes	No	0	7	7
20	R:R:E132	R:R:L69	74.951	5.3	Yes	Yes	0	9	7
21	R:R:E132	R:R:H143	12.5437	6.15	Yes	Yes	2	9	8
22	R:R:E132	R:R:R133	56.9583	5.82	Yes	Yes	2	9	9
23	R:R:L125	R:R:L73	12.6967	4.15	No	Yes	0	7	9
24	L:L:?1	R:R:W262	10.6588	8.45	Yes	Yes	1	0	9
25	R:R:N296	R:R:W262	10.941	10.17	Yes	Yes	1	9	9
26	R:R:D300	R:R:N296	14.2659	8.08	Yes	Yes	1	9	9
27	L:L:?1	R:R:M115	43.0273	10.49	Yes	No	0	0	8
28	R:R:M115	R:R:N84	11.783	8.41	No	No	0	8	6
29	R:R:F111	R:R:M115	31.7753	4.98	No	No	0	6	8
30	R:R:C186	R:R:F111	29.302	6.98	No	No	0	9	6
31	R:R:C186	R:R:W98	25.4174	3.92	No	Yes	0	9	5
32	R:R:D102	R:R:W98	11.7686	4.47	No	Yes	0	4	5
33	R:R:D102	R:R:L107	10.3287	6.79	No	No	0	4	5
34	R:R:I179	R:R:W98	10.343	16.44	No	Yes	0	5	5
35	R:R:F187	R:R:W185	35.5117	7.02	Yes	Yes	1	8	8
36	R:R:F187	R:R:Y188	67.2152	13.41	Yes	Yes	1	8	6
37	R:R:Y177	R:R:Y188	15.7776	6.95	Yes	Yes	1	7	6
38	R:R:I113	R:R:Y177	11.8452	4.84	No	Yes	0	5	7
39	L:L:?1	R:R:F265	41.4055	6.02	Yes	Yes	0	0	8
40	R:R:F187	R:R:F265	35.9374	4.29	Yes	Yes	0	8	8
41	R:R:Y188	R:R:Y201	33.9521	7.94	Yes	Yes	1	6	6
42	R:R:F200	R:R:Y201	16.2991	5.16	No	Yes	0	5	6
43	R:R:F200	R:R:L204	13.9693	6.09	No	No	0	5	4
44	R:R:L204	R:R:L208	11.6299	4.15	No	No	0	4	5
45	R:R:M247	R:R:R133	52.1313	8.69	No	Yes	2	8	9
46	R:R:L251	R:R:M247	51.8825	5.65	No	No	0	8	8
47	R:R:L251	R:R:T223	42.5059	2.95	No	Yes	0	8	8
48	R:R:C134	R:R:T223	38.9657	3.38	Yes	Yes	0	6	8
49	R:R:C134	R:R:C219	10.4435	1.82	Yes	No	0	6	7
50	R:R:L251	R:R:N220	10.4435	4.12	No	Yes	0	8	9
51	R:R:C134	R:R:T138	25.9054	3.38	Yes	No	0	6	7
52	R:R:T138	R:R:T226	14.7634	4.71	No	No	0	7	6
53	R:R:K139	R:R:T138	10.4435	3	No	No	0	5	7
54	R:R:R175	R:R:Y201	11.8308	4.12	No	Yes	1	8	6
55	R:R:L202	R:R:Y188	13.5005	4.69	No	Yes	0	6	6
56	R:R:R229	R:R:T226	13.3282	3.88	No	No	0	4	6
57	R:R:R229	R:R:V230	11.8835	3.92	No	No	0	4	7
58	R:R:H244	R:R:V230	10.4291	4.15	No	No	0	8	7
59	R:R:G273	R:R:L202	13.5818	3.42	No	No	0	4	6
60	R:R:G273	R:R:L203	10.1995	3.42	No	No	0	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S33	5.57	1	Yes	No	0	7	0	1
L:L:?1	R:R:H81	11.13	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:A88	3.9	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y92	7.25	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M115	10.49	1	Yes	No	0	8	0	1
L:L:?1	R:R:T184	6.38	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:W185	5.63	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W262	8.45	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F265	6.02	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L290	7.7	1	Yes	No	0	7	0	1
L:L:?1	R:R:T294	4.56	1	Yes	No	0	9	0	1
L:L:?1	R:R:Q297	7.41	1	Yes	Yes	0	8	0	1
R:R:L28	R:R:Y92	4.69	0	No	Yes	4	8	2	1
R:R:V30	R:R:Y92	11.36	0	No	Yes	6	8	2	1
R:R:F32	R:R:R291	23.52	0	No	No	4	8	2	1
R:R:F36	R:R:T294	3.89	0	No	No	8	9	2	1
R:R:G40	R:R:H81	7.94	1	No	Yes	9	8	2	1
R:R:G40	R:R:I298	5.29	1	No	Yes	9	8	2	2
R:R:D77	R:R:P122	6.44	1	Yes	No	9	9	2	2
R:R:D77	R:R:Q297	9.14	1	Yes	Yes	9	8	2	1
R:R:H81	R:R:Q297	4.95	1	Yes	Yes	8	8	1	1
R:R:H81	R:R:I298	6.63	1	Yes	Yes	8	8	1	2
R:R:M115	R:R:N84	8.41	0	No	No	8	6	1	2
R:R:K96	R:R:Y92	4.78	1	No	Yes	5	8	2	1
R:R:T184	R:R:Y92	13.73	1	Yes	Yes	9	8	1	1
R:R:K96	R:R:T184	4.5	1	No	Yes	5	9	2	1
R:R:F111	R:R:M115	4.98	0	No	No	6	8	2	1
R:R:P122	R:R:Q297	9.47	1	No	Yes	9	8	2	1
R:R:L123	R:R:W262	21.64	0	No	Yes	7	9	2	1
R:R:Q180	R:R:W185	21.9	1	No	Yes	8	8	2	1
R:R:F187	R:R:Q180	4.68	1	Yes	No	8	8	2	2
R:R:T184	R:R:W185	4.85	1	Yes	Yes	9	8	1	1
R:R:F187	R:R:W185	7.02	1	Yes	Yes	8	8	2	1
R:R:L290	R:R:W185	6.83	1	No	Yes	7	8	1	1
R:R:F187	R:R:F265	4.29	1	Yes	Yes	8	8	2	1
R:R:L266	R:R:W262	5.69	0	No	Yes	7	9	2	1
R:R:A293	R:R:W262	10.37	0	No	Yes	8	9	2	1
R:R:N296	R:R:W262	10.17	1	Yes	Yes	9	9	2	1
R:R:Q297	R:R:W262	7.67	1	Yes	Yes	8	9	1	1
R:R:F265	R:R:M269	8.71	0	Yes	No	8	7	1	2
R:R:L287	R:R:R291	7.29	0	No	No	6	8	2	1
R:R:N296	R:R:Q297	6.6	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:R291	3.76	1	Yes	No	0	8	0	1
L:L:?1	R:R:G119	3.17	1	Yes	No	0	7	0	1
R:R:A289	R:R:F265	2.77	0	No	Yes	7	8	2	1
R:R:S33	R:R:V89	1.62	0	No	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XJK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	255
Number of Links	284
Number of Hubs	37
Number of Links mediated by Hubs	140
Number of Communities	4
Number of Nodes involved in Communities	46
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	45204
Length Of Smallest Path	3
Average Path Length	12.3902
Length of Longest Path	31
Minimum Path Strength	1.52
Average Path Strength	6.60613
Maximum Path Strength	17.485
Minimum Path Correlation	0.7
Average Path Correlation	0.923276
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	50.5618
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.6121
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • defense response • response to stress • inflammatory response • response to ketone • response to prostaglandin • response to lipid • cellular response to prostaglandin D stimulus • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to prostaglandin D • response to chemical • cellular response to lipid • cellular response to ketone • cellular response to hormone stimulus • multi-multicellular organism process • multicellular organismal process • reproductive process • parturition • multi-organism reproductive process • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to estradiol • cellular anatomical structure • extracellular region • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • cellular response to prostaglandin E stimulus • response to prostaglandin E • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43088
Sequence	>8XJK_nogp_Chain_R N R L S V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q K S K A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D K E W I R F D Q S N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K P I F H S T K I T S K H V K M M L S G V C L F A V F I A L L P I L G H R D Y K I Q A S R T W C F Y N T E D I K D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N G N H S L E T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A V L K N L Y K L A S Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IUK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.67	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.67	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.78	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.78	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-		3.14	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IQ4	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8IQ4 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-		2.7	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8IQ6	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.4	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8IQ6 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		3.4	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8XJK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-		2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.77	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.77	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.85	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.85	2024-02-28	doi.org/10.1016/j.celrep.2024.113893

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