psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S33	17.77	Yes	No	0	0	7
2	L:L:?1	R:R:F36	3.39	Yes	Yes	1	0	8
3	L:L:?1	R:R:H81	8.95	Yes	Yes	1	0	8
4	L:L:?1	R:R:N84	13.39	Yes	Yes	1	0	6
5	L:L:?1	R:R:G85	3.57	Yes	No	0	0	7
6	L:L:?1	R:R:Y92	2.45	Yes	Yes	1	0	8
7	L:L:?1	R:R:M115	7.88	Yes	Yes	1	0	8
8	L:L:?1	R:R:G119	3.57	Yes	No	1	0	7
9	L:L:?1	R:R:W185	2.38	Yes	Yes	1	0	8
10	L:L:?1	R:R:W262	2.38	Yes	Yes	1	0	9
11	L:L:?1	R:R:L287	3.86	Yes	No	1	0	6
12	L:L:?1	R:R:L290	7.71	Yes	No	1	0	7
13	L:L:?1	R:R:R291	7.61	Yes	Yes	1	0	8
14	L:L:?1	R:R:A293	2.19	Yes	No	0	0	8
15	L:L:?1	R:R:T294	15.4	Yes	Yes	1	0	9
16	L:L:?1	R:R:Q297	6.49	Yes	Yes	1	0	8
17	R:R:S29	R:R:Y92	5.09	No	Yes	0	7	8
18	R:R:F31	R:R:V30	6.55	No	No	0	4	6
19	R:R:V30	R:R:Y92	8.83	No	Yes	0	6	8
20	R:R:F31	R:R:V34	3.93	No	No	0	4	4
21	R:R:F32	R:R:F36	3.22	No	Yes	1	4	8
22	R:R:F32	R:R:R291	16.03	No	Yes	1	4	8
23	R:R:F36	R:R:R291	2.14	Yes	Yes	1	8	8
24	R:R:F36	R:R:T294	10.38	Yes	Yes	1	8	9
25	R:R:F36	R:R:W295	14.03	Yes	Yes	1	8	5
26	R:R:F36	R:R:I298	3.77	Yes	Yes	1	8	8
27	R:R:I41	R:R:M37	2.92	No	No	0	6	7
28	R:R:G85	R:R:M37	3.49	No	No	0	7	7
29	R:R:V39	R:R:W295	3.68	Yes	Yes	1	6	5
30	R:R:I298	R:R:V39	3.07	Yes	Yes	1	8	6
31	R:R:G40	R:R:I298	5.29	No	Yes	0	9	8
32	R:R:F78	R:R:I41	10.05	No	No	0	7	6
33	R:R:S43	R:R:W302	8.65	No	No	0	9	6
34	R:R:N44	R:R:V74	5.91	No	No	0	9	8
35	R:R:F78	R:R:N44	8.46	No	No	0	7	9
36	R:R:A47	R:R:V74	5.09	No	No	0	9	8
37	R:R:A47	R:R:P301	1.87	No	No	0	9	9
38	R:R:I48	R:R:M52	4.37	No	No	0	7	4
39	R:R:I48	R:R:V74	4.61	No	No	0	7	8
40	R:R:I48	R:R:I75	2.94	No	No	0	7	6
41	R:R:I305	R:R:I50	2.94	No	Yes	0	8	8
42	R:R:I50	R:R:V311	9.22	Yes	No	4	8	7
43	R:R:I50	R:R:L315	2.85	Yes	No	4	8	4
44	R:R:A70	R:R:L51	4.73	No	No	0	8	8
45	R:R:I305	R:R:L51	9.99	No	No	0	8	8
46	R:R:M52	R:R:Q56	2.72	No	No	0	4	4
47	R:R:K53	R:R:N314	5.6	No	No	0	4	5
48	R:R:A54	R:R:L67	3.15	No	Yes	0	7	8
49	R:R:Q56	R:R:Y55	5.64	No	Yes	0	4	6
50	R:R:R59	R:R:Y55	9.26	No	Yes	0	5	6
51	R:R:A64	R:R:Y55	2.67	No	Yes	5	7	6
52	R:R:L67	R:R:Y55	2.34	Yes	Yes	5	8	6
53	R:R:L68	R:R:Y55	9.38	No	Yes	0	6	6
54	R:R:F58	R:R:R57	8.55	No	No	0	4	4
55	R:R:F58	R:R:L67	3.65	No	Yes	0	4	8
56	R:R:I147	R:R:K63	2.91	Yes	No	0	5	6
57	R:R:A64	R:R:L67	3.15	No	Yes	5	7	8
58	R:R:L69	R:R:S65	3	No	No	6	7	7
59	R:R:S65	R:R:V152	4.85	No	No	6	7	7
60	R:R:F66	R:R:M129	6.22	No	No	0	7	9
61	R:R:E132	R:R:F66	2.33	No	No	2	9	7
62	R:R:F66	R:R:R133	17.1	No	Yes	2	7	9
63	R:R:L69	R:R:V152	4.47	No	No	6	7	7
64	R:R:I75	R:R:S71	3.1	No	No	0	6	6
65	R:R:D77	R:R:L73	8.14	No	No	0	9	9
66	R:R:L125	R:R:L73	5.54	No	No	0	7	9
67	R:R:D300	R:R:L73	5.43	No	No	0	9	9
68	R:R:F79	R:R:I75	2.51	No	No	0	5	6
69	R:R:D77	R:R:T76	2.89	No	No	0	9	8
70	R:R:F117	R:R:T76	3.89	No	No	7	7	8
71	R:R:C121	R:R:T76	3.38	Yes	No	7	7	8
72	R:R:D77	R:R:P122	8.05	No	No	0	9	9
73	R:R:F78	R:R:L82	2.44	No	No	0	7	5
74	R:R:H81	R:R:T294	2.74	Yes	Yes	1	8	9
75	R:R:H81	R:R:Q297	2.47	Yes	Yes	1	8	8
76	R:R:H81	R:R:I298	5.3	Yes	Yes	1	8	8
77	R:R:I83	R:R:I87	2.94	No	No	0	5	6
78	R:R:C114	R:R:I83	4.91	No	No	0	4	5
79	R:R:F111	R:R:N84	6.04	Yes	Yes	1	6	6
80	R:R:M115	R:R:N84	2.8	Yes	Yes	1	8	6
81	R:R:N84	R:R:S118	2.98	Yes	No	0	6	7
82	R:R:A88	R:R:G85	1.95	No	No	0	8	7
83	R:R:F111	R:R:I87	18.84	Yes	No	0	6	6
84	R:R:F101	R:R:F90	8.57	Yes	No	3	4	5
85	R:R:F90	R:R:L107	2.44	No	No	3	5	5
86	R:R:V91	R:R:W98	9.81	No	Yes	3	7	5
87	R:R:F101	R:R:V91	5.24	Yes	No	3	4	7
88	R:R:K96	R:R:Y92	7.17	No	Yes	1	5	8
89	R:R:T184	R:R:Y92	8.74	Yes	Yes	1	9	8
90	R:R:R100	R:R:S94	7.91	No	No	0	1	4
91	R:R:F101	R:R:S94	5.28	Yes	No	0	4	4
92	R:R:K96	R:R:T184	4.5	No	Yes	1	5	9
93	R:R:E97	R:R:R100	3.49	No	No	0	4	1
94	R:R:F101	R:R:W98	6.01	Yes	Yes	3	4	5
95	R:R:I179	R:R:W98	4.7	No	Yes	3	5	5
96	R:R:R183	R:R:W98	2	No	Yes	3	6	5
97	R:R:F101	R:R:L107	2.44	Yes	No	3	4	5
98	R:R:D102	R:R:N105	5.39	No	No	0	4	1
99	R:R:S104	R:R:V106	3.23	No	No	0	5	3
100	R:R:D176	R:R:N105	2.69	No	No	0	3	1
101	R:R:C108	R:R:C186	7.28	No	No	0	9	9
102	R:R:I171	R:R:S109	3.1	No	No	0	4	4
103	R:R:F111	R:R:M115	3.73	Yes	Yes	1	6	8
104	R:R:F111	R:R:W185	2	Yes	Yes	1	6	8
105	R:R:G112	R:R:Y177	8.69	No	Yes	0	7	7
106	R:R:I113	R:R:L168	2.85	No	No	0	5	4
107	R:R:I113	R:R:I171	4.42	No	No	1	5	4
108	R:R:I113	R:R:Y177	3.63	No	Yes	1	5	7
109	R:R:F187	R:R:M115	4.98	Yes	Yes	1	8	8
110	R:R:L120	R:R:V116	2.98	No	Yes	0	6	8
111	R:R:A167	R:R:V116	3.39	No	Yes	0	8	8
112	R:R:V116	R:R:Y177	5.05	Yes	Yes	1	8	7
113	R:R:F187	R:R:V116	3.93	Yes	Yes	1	8	8
114	R:R:V116	R:R:Y188	6.31	Yes	Yes	1	8	6
115	R:R:C121	R:R:F117	12.57	Yes	No	7	7	7
116	R:R:A163	R:R:F117	2.77	No	No	0	7	7
117	R:R:G119	R:R:W262	2.81	No	Yes	1	7	9
118	R:R:I166	R:R:L120	2.85	No	No	0	6	6
119	R:R:F205	R:R:L120	8.53	Yes	No	0	8	6
120	R:R:C121	R:R:P122	3.77	Yes	No	0	7	9
121	R:R:C121	R:R:L125	3.17	Yes	No	0	7	7
122	R:R:L123	R:R:W262	20.5	No	Yes	0	7	9
123	R:R:L124	R:R:V159	2.98	No	No	0	5	5
124	R:R:S127	R:R:V215	3.23	No	No	0	7	5
125	R:R:M155	R:R:V128	3.04	No	No	0	5	7
126	R:R:M129	R:R:Y304	2.39	No	Yes	0	9	9
127	R:R:A130	R:R:S216	3.42	No	No	8	9	8
128	R:R:A130	R:R:N220	4.69	No	Yes	8	9	9
129	R:R:I131	R:R:I135	2.94	No	No	0	6	5
130	R:R:I131	R:R:V215	3.07	No	No	0	6	5
131	R:R:C219	R:R:I131	3.27	No	No	0	7	6
132	R:R:E132	R:R:R133	4.65	No	Yes	2	9	9
133	R:R:E132	R:R:H143	13.54	No	No	0	9	8
134	R:R:M247	R:R:R133	4.96	No	Yes	2	8	9
135	R:R:Q250	R:R:R133	8.18	Yes	Yes	2	8	9
136	R:R:R133	R:R:Y304	2.06	Yes	Yes	2	9	9
137	R:R:C134	R:R:C219	3.64	No	No	0	6	7
138	R:R:C134	R:R:I222	3.27	No	No	0	6	4
139	R:R:C134	R:R:T223	3.38	No	Yes	0	6	8
140	R:R:F142	R:R:I135	2.51	Yes	No	0	4	5
141	R:R:G136	R:R:H143	6.35	No	No	0	8	8
142	R:R:T223	R:R:V137	4.76	Yes	No	0	8	8
143	R:R:T226	R:R:V137	3.17	No	No	0	6	8
144	R:R:K139	R:R:T138	4.5	No	No	0	5	7
145	R:R:F142	R:R:K139	8.69	Yes	No	0	4	5
146	R:R:F142	R:R:K146	8.69	Yes	No	0	4	4
147	R:R:F142	R:R:I147	5.02	Yes	Yes	0	4	5
148	R:R:H143	R:R:I147	5.3	No	Yes	0	8	5
149	R:R:K146	R:R:T145	4.5	No	No	0	4	5
150	R:R:H151	R:R:T148	13.69	No	No	0	5	7
151	R:R:K153	R:R:S149	4.59	No	No	0	5	3
152	R:R:C160	R:R:L156	3.17	No	No	0	6	7
153	R:R:F162	R:R:I166	11.3	No	No	0	4	6
154	R:R:F162	R:R:L208	3.65	No	No	0	4	5
155	R:R:L168	R:R:V164	2.98	No	No	0	4	4
156	R:R:L169	R:R:P170	3.28	No	No	0	6	9
157	R:R:L169	R:R:Y201	3.52	No	Yes	0	6	6
158	R:R:P170	R:R:Y177	12.52	No	Yes	1	9	7
159	R:R:P170	R:R:Y188	6.95	No	Yes	1	9	6
160	R:R:I171	R:R:Y177	3.63	No	Yes	1	4	7
161	R:R:E197	R:R:R175	3.49	Yes	No	0	2	8
162	R:R:D198	R:R:R175	15.48	No	No	0	5	8
163	R:R:Y177	R:R:Y188	4.96	Yes	Yes	1	7	6
164	R:R:K178	R:R:N189	11.19	No	No	0	5	6
165	R:R:I179	R:R:R183	8.77	No	No	3	5	6
166	R:R:C186	R:R:I179	3.27	No	No	0	9	5
167	R:R:Q180	R:R:W185	13.14	No	Yes	1	8	8
168	R:R:F187	R:R:Q180	5.86	Yes	No	1	8	8
169	R:R:Q180	R:R:T190	12.76	No	No	0	8	7
170	R:R:A181	R:R:C283	3.61	No	No	0	4	4
171	R:R:S182	R:R:T184	7.99	No	Yes	1	8	9
172	R:R:S182	R:R:W185	4.94	No	Yes	1	8	8
173	R:R:T184	R:R:W185	6.06	Yes	Yes	1	9	8
174	R:R:F187	R:R:W185	4.01	Yes	Yes	1	8	8
175	R:R:T286	R:R:W185	2.43	No	Yes	0	7	8
176	R:R:L290	R:R:W185	6.83	No	Yes	1	7	8
177	R:R:F187	R:R:Y188	13.41	Yes	Yes	1	8	6
178	R:R:F187	R:R:F205	2.14	Yes	Yes	0	8	8
179	R:R:Y188	R:R:Y201	3.97	Yes	Yes	0	6	6
180	R:R:L202	R:R:Y188	4.69	No	Yes	0	6	6
181	R:R:I193	R:R:N189	2.83	No	No	0	1	6
182	R:R:D198	R:R:N189	5.39	No	No	0	5	6
183	R:R:I193	R:R:R199	6.26	No	No	0	1	3
184	R:R:I193	R:R:N277	2.83	No	No	0	1	1
185	R:R:D195	R:R:W196	4.47	No	No	9	1	1
186	R:R:D195	R:R:E197	9.09	No	Yes	9	1	2
187	R:R:E197	R:R:W196	4.36	Yes	No	9	2	1
188	R:R:F200	R:R:W196	2	No	No	0	5	1
189	R:R:E197	R:R:Y201	2.24	Yes	Yes	0	2	6
190	R:R:G276	R:R:R199	4.5	No	No	0	1	3
191	R:R:F200	R:R:Y201	2.06	No	Yes	0	5	6
192	R:R:G273	R:R:L202	3.42	No	No	0	4	6
193	R:R:L204	R:R:L208	4.15	No	No	0	4	5
194	R:R:F205	R:R:F265	3.22	Yes	Yes	0	8	8
195	R:R:F205	R:R:L266	2.44	Yes	Yes	0	8	7
196	R:R:A270	R:R:S206	3.42	No	No	0	5	7
197	R:R:F207	R:R:L211	2.44	No	No	0	4	4
198	R:R:G209	R:R:L266	3.42	No	Yes	0	7	7
199	R:R:L210	R:R:L266	5.54	No	Yes	0	5	7
200	R:R:L211	R:R:V215	2.98	No	No	0	4	5
201	R:R:L213	R:R:L217	2.77	No	No	10	8	5
202	R:R:N220	R:R:S216	4.47	Yes	No	8	9	8
203	R:R:L217	R:R:M255	7.07	No	No	0	5	8
204	R:R:I222	R:R:L218	5.71	No	No	0	4	3
205	R:R:L251	R:R:N220	5.49	No	Yes	0	8	9
206	R:R:M255	R:R:N220	5.61	No	Yes	0	8	9
207	R:R:L227	R:R:T223	2.95	No	Yes	0	8	8
208	R:R:L251	R:R:T223	2.95	No	Yes	0	8	8
209	R:R:I225	R:R:R229	6.26	No	No	0	3	4
210	R:R:L227	R:R:V248	2.98	No	No	0	8	7
211	R:R:F232	R:R:L228	4.87	No	No	0	5	5
212	R:R:H244	R:R:V230	2.77	Yes	No	0	8	7
213	R:R:K231	R:R:R241	6.19	No	No	0	6	4
214	R:R:H244	R:R:K231	15.72	Yes	No	0	8	6
215	R:R:Q236	R:R:S234	7.22	No	No	0	3	4
216	R:R:H243	R:R:S242	2.79	No	No	0	5	6
217	R:R:I249	R:R:L245	5.71	No	No	0	6	4
218	R:R:E246	R:R:R308	8.14	No	Yes	0	7	9
219	R:R:E246	R:R:K309	8.1	No	No	0	7	7
220	R:R:M247	R:R:Q250	4.08	No	Yes	2	8	8
221	R:R:L252	R:R:V248	2.98	No	No	0	5	7
222	R:R:I254	R:R:Q250	5.49	No	Yes	2	8	8
223	R:R:Q250	R:R:R308	22.2	Yes	Yes	0	8	9
224	R:R:I254	R:R:V303	4.61	No	No	2	8	8
225	R:R:I254	R:R:Y304	15.71	No	Yes	2	8	9
226	R:R:N296	R:R:S258	2.98	Yes	No	0	9	9
227	R:R:C261	R:R:M292	3.24	No	No	0	8	6
228	R:R:C261	R:R:N296	9.45	No	Yes	0	8	9
229	R:R:F265	R:R:W262	2	Yes	Yes	0	8	9
230	R:R:L266	R:R:W262	3.42	Yes	Yes	0	7	9
231	R:R:N296	R:R:W262	12.43	Yes	Yes	1	9	9
232	R:R:Q297	R:R:W262	12.05	Yes	Yes	1	8	9
233	R:R:P264	R:R:S263	3.56	No	No	0	9	5
234	R:R:M292	R:R:P264	5.03	No	No	0	6	9
235	R:R:F265	R:R:M269	8.71	Yes	No	0	8	7
236	R:R:A289	R:R:F265	4.16	No	Yes	0	7	8
237	R:R:I272	R:R:T268	3.04	No	No	0	6	5
238	R:R:M269	R:R:T286	3.01	No	No	0	7	7
239	R:R:N271	R:R:N275	9.54	No	No	0	4	1
240	R:R:N271	R:R:S279	2.98	No	No	0	4	1
241	R:R:I274	R:R:N275	5.66	No	No	0	3	1
242	R:R:E281	R:R:T285	8.47	No	No	0	1	2
243	R:R:E284	R:R:T282	2.82	No	No	0	1	4
244	R:R:L287	R:R:R291	15.79	No	Yes	1	6	8
245	R:R:F288	R:R:M292	2.49	No	No	0	4	6
246	R:R:T294	R:R:W295	2.43	Yes	Yes	1	9	5
247	R:R:I298	R:R:W295	11.74	Yes	Yes	1	8	5
248	R:R:L299	R:R:W295	5.69	No	Yes	0	7	5
249	R:R:N296	R:R:Q297	7.92	Yes	Yes	1	9	8
250	R:R:L299	R:R:W302	4.56	No	No	0	7	6
251	R:R:D300	R:R:P301	4.83	No	No	0	9	9
252	R:R:D300	R:R:Y304	12.64	No	Yes	0	9	9
253	R:R:L306	R:R:W302	18.22	No	No	0	8	6
254	R:R:V303	R:R:Y304	2.52	No	Yes	2	8	9
255	R:R:L307	R:R:V303	2.98	No	No	0	6	8
256	R:R:I305	R:R:Y304	2.42	No	Yes	0	8	9
257	R:R:L307	R:R:R308	2.43	No	Yes	0	6	9
258	R:R:R308	R:R:V311	3.92	Yes	No	0	9	7
259	R:R:L315	R:R:V311	2.98	No	No	4	4	7
260	R:R:G72	R:R:S71	1.86	No	No	0	8	6
261	R:R:G80	R:R:S118	1.86	No	No	0	8	7
262	R:R:G158	R:R:S157	1.86	No	No	0	1	3
263	R:R:G224	R:R:T223	1.82	No	Yes	0	7	8
264	R:R:G273	R:R:I272	1.76	No	No	0	4	6
265	R:R:G126	R:R:M129	1.75	No	No	0	8	9
266	R:R:G240	R:R:K231	1.74	No	No	0	4	6
267	R:R:C259	R:R:S263	1.72	No	No	0	5	5
268	R:R:A212	R:R:S127	1.71	No	No	0	7	7
269	R:R:G158	R:R:L161	1.71	No	No	0	1	3
270	R:R:G214	R:R:L213	1.71	No	No	10	3	8
271	R:R:G214	R:R:L217	1.71	No	No	10	3	5
272	R:R:C261	R:R:V257	1.71	No	No	0	8	7
273	R:R:K139	R:R:P140	1.67	No	No	0	5	8
274	R:R:C114	R:R:I110	1.64	No	No	0	4	5
275	R:R:S263	R:R:V267	1.62	No	No	0	5	6
276	R:R:V128	R:R:V159	1.6	No	No	0	7	5
277	R:R:T38	R:R:V39	1.59	No	Yes	0	5	6
278	R:R:G173	R:R:H174	1.59	No	No	0	7	4
279	R:R:A212	R:R:L124	1.58	No	No	0	7	5
280	R:R:T268	R:R:T285	1.57	No	No	0	5	2
281	R:R:I41	R:R:S45	1.55	No	No	0	6	5
282	R:R:I272	R:R:S279	1.55	No	No	0	6	1
283	R:R:I35	R:R:V34	1.54	No	No	0	4	4
284	R:R:I35	R:R:V39	1.54	No	Yes	0	4	6
285	R:R:I87	R:R:V91	1.54	No	No	0	6	7
286	R:R:I110	R:R:V106	1.54	No	No	0	5	3
287	R:R:I147	R:R:V152	1.54	Yes	No	0	5	7
288	R:R:K63	R:R:S149	1.53	No	No	0	6	3
289	R:R:M269	R:R:S206	1.53	No	No	0	7	7
290	R:R:I141	R:R:T145	1.52	No	No	0	5	5
291	R:R:L228	R:R:V248	1.49	No	No	0	5	7
292	R:R:D176	R:R:S109	1.47	No	No	0	3	4
293	R:R:G173	R:R:Y201	1.45	No	Yes	0	7	6
294	R:R:K150	R:R:M154	1.44	No	No	0	5	3
295	R:R:K309	R:R:K313	1.44	No	No	0	7	4
296	R:R:I50	R:R:N314	1.42	Yes	No	0	8	5
297	R:R:L306	R:R:L46	1.38	No	No	0	8	5
298	R:R:L125	R:R:L156	1.38	No	No	0	7	7
299	R:R:E97	R:R:I99	1.37	No	No	0	4	1
300	R:R:I99	R:R:Q103	1.37	No	No	0	1	4
301	R:R:D192	R:R:N277	1.35	No	No	0	2	1
302	R:R:H151	R:R:K150	1.31	No	No	0	5	5
303	R:R:D95	R:R:E97	1.3	No	No	0	4	4
304	R:R:D192	R:R:E191	1.3	No	No	0	2	3
305	R:R:H244	R:R:L227	1.29	Yes	No	0	8	8
306	R:R:F165	R:R:I166	1.26	No	No	0	3	6
307	R:R:H243	R:R:H244	1.19	No	Yes	0	5	8
308	R:R:Q60	R:R:R59	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.81188	16	1	0
2	R:R:F36	6.155	6	1	8
3	R:R:V39	2.47	4	1	6
4	R:R:I50	4.1075	4	4	8
5	R:R:Y55	5.858	5	5	6
6	R:R:L67	3.0725	4	5	8
7	R:R:H81	4.865	4	1	8
8	R:R:N84	6.3025	4	1	6
9	R:R:Y92	6.456	5	1	8
10	R:R:W98	5.63	4	3	5
11	R:R:F101	5.508	5	3	4
12	R:R:F111	7.6525	4	1	6
13	R:R:M115	4.8475	4	1	8
14	R:R:V116	4.332	5	1	8
15	R:R:C121	5.7225	4	7	7
16	R:R:R133	7.39	5	2	9
17	R:R:F142	6.2275	4	0	4
18	R:R:I147	3.6925	4	0	5
19	R:R:Y177	6.41333	6	1	7
20	R:R:T184	6.8225	4	1	9
21	R:R:W185	5.22375	8	1	8
22	R:R:F187	5.72167	6	1	8
23	R:R:Y188	6.715	6	1	6
24	R:R:E197	4.795	4	9	2
25	R:R:Y201	2.648	5	0	6
26	R:R:F205	4.0825	4	0	8
27	R:R:N220	5.065	4	8	9
28	R:R:T223	3.172	5	0	8
29	R:R:H244	5.2425	4	0	8
30	R:R:Q250	9.9875	4	2	8
31	R:R:W262	7.94143	7	1	9
32	R:R:F265	4.5225	4	0	8
33	R:R:L266	3.705	4	0	7
34	R:R:R291	10.3925	4	1	8
35	R:R:T294	7.7375	4	1	9
36	R:R:W295	7.514	5	1	5
37	R:R:N296	8.195	4	1	9
38	R:R:Q297	7.2325	4	1	8
39	R:R:I298	5.834	5	1	8
40	R:R:Y304	6.29	6	2	9
41	R:R:R308	9.1725	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F36	15.9537	3.39	Yes	Yes	1	0	8
2	L:L:?1	R:R:T294	10.0836	15.4	Yes	Yes	1	0	9
3	L:L:?1	R:R:G85	100	3.57	Yes	No	0	0	7
4	R:R:G85	R:R:M37	99.0688	3.49	No	No	0	7	7
5	R:R:I41	R:R:M37	98.5955	2.92	No	No	0	6	7
6	R:R:F78	R:R:I41	97.6334	10.05	No	No	0	7	6
7	R:R:L299	R:R:W295	10.737	5.69	No	Yes	0	7	5
8	R:R:F78	R:R:N44	96.6508	8.46	No	No	0	7	9
9	R:R:N44	R:R:V74	96.1518	5.91	No	No	0	9	8
10	R:R:A47	R:R:V74	86.881	5.09	No	No	0	9	8
11	R:R:A47	R:R:P301	86.2894	1.87	No	No	0	9	9
12	R:R:I48	R:R:V74	17.2424	4.61	No	No	0	7	8
13	R:R:I48	R:R:M52	11.9949	4.37	No	No	0	7	4
14	R:R:D300	R:R:P301	85.6926	4.83	No	No	0	9	9
15	R:R:D300	R:R:Y304	77.4662	12.64	No	Yes	0	9	9
16	R:R:M52	R:R:Q56	10.9299	2.72	No	No	0	4	4
17	R:R:R133	R:R:Y304	58.1351	2.06	Yes	Yes	2	9	9
18	R:R:E132	R:R:R133	52.7846	4.65	No	Yes	2	9	9
19	R:R:E132	R:R:H143	52.3884	13.54	No	No	0	9	8
20	R:R:H143	R:R:I147	50.7421	5.3	No	Yes	0	8	5
21	R:R:D300	R:R:L73	13.0547	5.43	No	No	0	9	9
22	L:L:?1	R:R:N84	12.9286	13.39	Yes	Yes	1	0	6
23	R:R:F111	R:R:N84	11.501	6.04	Yes	Yes	1	6	6
24	R:R:F111	R:R:I87	41.5383	18.84	Yes	No	0	6	6
25	R:R:I83	R:R:I87	10.0939	2.94	No	No	0	5	6
26	L:L:?1	R:R:M115	44.7125	7.88	Yes	Yes	1	0	8
27	R:R:F111	R:R:M115	15.4418	3.73	Yes	Yes	1	6	8
28	L:L:?1	R:R:W185	48.445	2.38	Yes	Yes	1	0	8
29	R:R:F111	R:R:W185	16.4527	2	Yes	Yes	1	6	8
30	R:R:I87	R:R:V91	29.901	1.54	No	No	0	6	7
31	R:R:F101	R:R:V91	17.9627	5.24	Yes	No	3	4	7
32	R:R:F101	R:R:S94	12.0977	5.28	Yes	No	0	4	4
33	R:R:R100	R:R:S94	10.0939	7.91	No	No	0	1	4
34	R:R:F187	R:R:M115	37.7286	4.98	Yes	Yes	1	8	8
35	R:R:F187	R:R:V116	21.0367	3.93	Yes	Yes	1	8	8
36	R:R:V116	R:R:Y177	13.3994	5.05	Yes	Yes	1	8	7
37	R:R:I171	R:R:Y177	13.5023	3.63	No	Yes	1	4	7
38	R:R:I171	R:R:S109	10.8424	3.1	No	No	0	4	4
39	R:R:F187	R:R:W185	39.2797	4.01	Yes	Yes	1	8	8
40	R:R:F187	R:R:Y188	52.2598	13.41	Yes	Yes	1	8	6
41	R:R:Y177	R:R:Y188	13.0598	4.96	Yes	Yes	1	7	6
42	R:R:F187	R:R:F205	12.3241	2.14	Yes	Yes	0	8	8
43	R:R:F205	R:R:L120	13.0675	8.53	Yes	No	0	8	6
44	L:L:?1	R:R:W262	21.1704	2.38	Yes	Yes	1	0	9
45	R:R:I166	R:R:L120	15.8354	2.85	No	No	0	6	6
46	R:R:F142	R:R:I147	45.0032	5.02	Yes	Yes	0	4	5
47	R:R:F142	R:R:I135	38.827	2.51	Yes	No	0	4	5
48	R:R:I131	R:R:I135	37.9241	2.94	No	No	0	6	5
49	R:R:C219	R:R:I131	28.6122	3.27	No	No	0	7	6
50	R:R:C134	R:R:C219	27.6527	3.64	No	No	0	6	7
51	R:R:C134	R:R:T223	24.7434	3.38	No	Yes	0	6	8
52	R:R:Y188	R:R:Y201	25.1627	3.97	Yes	Yes	0	6	6
53	R:R:E197	R:R:Y201	17.5151	2.24	Yes	Yes	0	2	6
54	R:R:E197	R:R:R175	13.5794	3.49	Yes	No	0	2	8
55	R:R:D198	R:R:R175	12.2444	15.48	No	No	0	5	8
56	R:R:D198	R:R:N189	10.9042	5.39	No	No	0	5	6
57	R:R:L202	R:R:Y188	13.5794	4.69	No	Yes	0	6	6
58	R:R:G273	R:R:L202	12.2444	3.42	No	No	0	4	6
59	R:R:L227	R:R:T223	12.6328	2.95	No	Yes	0	8	8
60	R:R:N296	R:R:W262	12.9363	12.43	Yes	Yes	1	9	9
61	R:R:C261	R:R:N296	17.8804	9.45	No	Yes	0	8	9
62	R:R:C261	R:R:M292	13.4405	3.24	No	No	0	8	6
63	R:R:G273	R:R:I272	10.9042	1.76	No	No	0	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S33	17.77	1	Yes	No	0	7	0	1
L:L:?1	R:R:F36	3.39	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:H81	8.95	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N84	13.39	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:G85	3.57	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y92	2.45	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M115	7.88	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:G119	3.57	1	Yes	No	0	7	0	1
L:L:?1	R:R:W185	2.38	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W262	2.38	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:L287	3.86	1	Yes	No	0	6	0	1
L:L:?1	R:R:L290	7.71	1	Yes	No	0	7	0	1
L:L:?1	R:R:R291	7.61	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:A293	2.19	1	Yes	No	0	8	0	1
L:L:?1	R:R:T294	15.4	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Q297	6.49	1	Yes	Yes	0	8	0	1
R:R:S29	R:R:Y92	5.09	0	No	Yes	7	8	2	1
R:R:V30	R:R:Y92	8.83	0	No	Yes	6	8	2	1
R:R:F32	R:R:F36	3.22	1	No	Yes	4	8	2	1
R:R:F32	R:R:R291	16.03	1	No	Yes	4	8	2	1
R:R:F36	R:R:R291	2.14	1	Yes	Yes	8	8	1	1
R:R:F36	R:R:T294	10.38	1	Yes	Yes	8	9	1	1
R:R:F36	R:R:W295	14.03	1	Yes	Yes	8	5	1	2
R:R:F36	R:R:I298	3.77	1	Yes	Yes	8	8	1	2
R:R:G85	R:R:M37	3.49	0	No	No	7	7	1	2
R:R:H81	R:R:T294	2.74	1	Yes	Yes	8	9	1	1
R:R:H81	R:R:Q297	2.47	1	Yes	Yes	8	8	1	1
R:R:H81	R:R:I298	5.3	1	Yes	Yes	8	8	1	2
R:R:F111	R:R:N84	6.04	1	Yes	Yes	6	6	2	1
R:R:M115	R:R:N84	2.8	1	Yes	Yes	8	6	1	1
R:R:N84	R:R:S118	2.98	1	Yes	No	6	7	1	2
R:R:A88	R:R:G85	1.95	0	No	No	8	7	2	1
R:R:K96	R:R:Y92	7.17	1	No	Yes	5	8	2	1
R:R:T184	R:R:Y92	8.74	1	Yes	Yes	9	8	2	1
R:R:K96	R:R:T184	4.5	1	No	Yes	5	9	2	2
R:R:F111	R:R:M115	3.73	1	Yes	Yes	6	8	2	1
R:R:F111	R:R:W185	2	1	Yes	Yes	6	8	2	1
R:R:F187	R:R:M115	4.98	1	Yes	Yes	8	8	2	1
R:R:G119	R:R:W262	2.81	1	No	Yes	7	9	1	1
R:R:L123	R:R:W262	20.5	0	No	Yes	7	9	2	1
R:R:Q180	R:R:W185	13.14	1	No	Yes	8	8	2	1
R:R:F187	R:R:Q180	5.86	1	Yes	No	8	8	2	2
R:R:S182	R:R:T184	7.99	1	No	Yes	8	9	2	2
R:R:S182	R:R:W185	4.94	1	No	Yes	8	8	2	1
R:R:T184	R:R:W185	6.06	1	Yes	Yes	9	8	2	1
R:R:F187	R:R:W185	4.01	1	Yes	Yes	8	8	2	1
R:R:T286	R:R:W185	2.43	0	No	Yes	7	8	2	1
R:R:L290	R:R:W185	6.83	1	No	Yes	7	8	1	1
R:R:F265	R:R:W262	2	0	Yes	Yes	8	9	2	1
R:R:L266	R:R:W262	3.42	0	Yes	Yes	7	9	2	1
R:R:N296	R:R:W262	12.43	1	Yes	Yes	9	9	2	1
R:R:Q297	R:R:W262	12.05	1	Yes	Yes	8	9	1	1
R:R:L287	R:R:R291	15.79	1	No	Yes	6	8	1	1
R:R:T294	R:R:W295	2.43	1	Yes	Yes	9	5	1	2
R:R:I298	R:R:W295	11.74	1	Yes	Yes	8	5	2	2
R:R:N296	R:R:Q297	7.92	1	Yes	Yes	9	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IUK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.87
Number of Linked Nodes	264
Number of Links	308
Number of Hubs	41
Number of Links mediated by Hubs	152
Number of Communities	10
Number of Nodes involved in Communities	67
Number of Links involved in Communities	97

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	72054
Length Of Smallest Path	3
Average Path Length	16.1486
Length of Longest Path	38
Minimum Path Strength	1.24
Average Path Strength	5.62439
Maximum Path Strength	16.585
Minimum Path Correlation	0.7
Average Path Correlation	0.928922
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	49.5454
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.7755
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UGU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	UGU
Name	Dinoprost
Synonyms	Dinoprost; Prostaglandin F2a; PGF2alpha
Identifier
Formula	C20 H34 O5
Molecular Weight	354.481
SMILES
PubChem	5280363
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	5
Total Bonds	59
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43088
Sequence	>8IUK_nogp_Chain_R S V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q K S K A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D K E W I R F D Q S N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K P I F H S T K I T S K H V K M M L S G V C L F A V F I A L L P I L G H R D Y K I Q A S R T W C F Y N T E D I K D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q Q H G R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N G N H S L E T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A V L K N L Y K L A S Q C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XJK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-		2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.85	2024-02-28	To be published
	8XJM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.85	2024-02-28	To be published
	8XJL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.77	2024-02-28	To be published
	8XJL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.77	2024-02-28	To be published
	8IQ6	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ6 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-		2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IUM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-		3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.67	2023-07-12	10.1038/s41467-023-38411-x
	8IUK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.67	2023-07-12	10.1038/s41467-023-38411-x

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