psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S33	5.84	Yes	No	0	0	7
2	L:L:?1	R:R:H81	7.5	Yes	Yes	1	0	8
3	L:L:?1	R:R:A88	4.08	Yes	No	0	0	8
4	L:L:?1	R:R:Y92	6.84	Yes	Yes	1	0	8
5	L:L:?1	R:R:M115	7.33	Yes	No	1	0	8
6	L:L:?1	R:R:T184	5.73	Yes	Yes	1	0	9
7	L:L:?1	R:R:W262	8.12	Yes	Yes	1	0	9
8	L:L:?1	R:R:F265	7.89	Yes	Yes	1	0	8
9	L:L:?1	R:R:L290	5.38	Yes	No	1	0	7
10	L:L:?1	R:R:R291	4.72	Yes	Yes	1	0	8
11	L:L:?1	R:R:T294	4.78	Yes	No	1	0	9
12	L:L:?1	R:R:Q297	6.04	Yes	Yes	1	0	8
13	R:R:F32	R:R:R27	4.28	No	No	1	4	2
14	R:R:R27	R:R:R291	7.46	No	Yes	1	2	8
15	R:R:L28	R:R:Y92	3.52	No	Yes	0	4	8
16	R:R:L28	R:R:L287	4.15	No	No	0	4	6
17	R:R:V30	R:R:Y92	11.36	No	Yes	0	6	8
18	R:R:F32	R:R:R291	13.9	No	Yes	1	4	8
19	R:R:F36	R:R:T294	6.49	No	No	1	8	9
20	R:R:F36	R:R:W295	14.03	No	No	1	8	5
21	R:R:F36	R:R:I298	3.77	No	Yes	1	8	8
22	R:R:I41	R:R:M37	4.37	No	No	0	6	7
23	R:R:G40	R:R:H81	9.53	No	Yes	0	9	8
24	R:R:F78	R:R:I41	5.02	Yes	No	0	7	6
25	R:R:P301	R:R:S43	3.56	No	No	0	9	9
26	R:R:S43	R:R:W302	8.65	No	No	0	9	6
27	R:R:N44	R:R:V74	5.91	Yes	No	0	9	8
28	R:R:D77	R:R:N44	6.73	Yes	Yes	0	9	9
29	R:R:F78	R:R:N44	4.83	Yes	Yes	0	7	9
30	R:R:N44	R:R:P301	13.03	Yes	No	0	9	9
31	R:R:L306	R:R:L46	5.54	No	No	0	8	5
32	R:R:L315	R:R:L46	4.15	No	No	0	4	5
33	R:R:I48	R:R:M52	4.37	No	No	0	7	4
34	R:R:I48	R:R:V74	4.61	No	No	0	7	8
35	R:R:L51	R:R:S71	7.51	No	No	0	8	6
36	R:R:I305	R:R:L51	9.99	No	No	0	8	8
37	R:R:R59	R:R:Y55	14.4	No	No	0	5	6
38	R:R:L67	R:R:Y55	3.52	Yes	No	0	8	6
39	R:R:L68	R:R:Y55	10.55	No	No	0	6	6
40	R:R:F58	R:R:R57	9.62	No	No	0	4	4
41	R:R:F58	R:R:L67	3.65	No	Yes	0	4	8
42	R:R:K63	R:R:S65	6.12	Yes	Yes	2	6	7
43	R:R:H143	R:R:K63	11.79	Yes	Yes	2	8	6
44	R:R:I147	R:R:K63	5.82	Yes	Yes	2	5	6
45	R:R:K63	R:R:S149	6.12	Yes	No	0	6	3
46	R:R:A64	R:R:L67	4.73	No	Yes	0	7	8
47	R:R:E132	R:R:S65	10.06	Yes	Yes	2	9	7
48	R:R:H143	R:R:S65	8.37	Yes	Yes	2	8	7
49	R:R:S65	R:R:V152	4.85	Yes	No	0	7	7
50	R:R:A70	R:R:F66	4.16	No	No	0	8	7
51	R:R:E132	R:R:F66	5.83	Yes	No	2	9	7
52	R:R:F66	R:R:R133	14.97	No	Yes	2	7	9
53	R:R:L68	R:R:V152	4.47	No	No	0	6	7
54	R:R:L69	R:R:M129	5.65	Yes	Yes	0	7	9
55	R:R:E132	R:R:L69	5.3	Yes	Yes	0	9	7
56	R:R:L69	R:R:V152	4.47	Yes	No	0	7	7
57	R:R:D77	R:R:L73	8.14	Yes	Yes	1	9	9
58	R:R:L125	R:R:L73	5.54	No	Yes	0	7	9
59	R:R:L73	R:R:M129	5.65	Yes	Yes	1	9	9
60	R:R:D300	R:R:L73	6.79	No	Yes	1	9	9
61	R:R:L73	R:R:Y304	3.52	Yes	No	1	9	9
62	R:R:F79	R:R:I75	3.77	No	No	0	5	6
63	R:R:C121	R:R:T76	6.76	Yes	No	0	7	8
64	R:R:D77	R:R:P122	6.44	Yes	No	1	9	9
65	R:R:D77	R:R:Q297	7.83	Yes	Yes	1	9	8
66	R:R:D300	R:R:D77	5.32	No	Yes	1	9	9
67	R:R:F78	R:R:F79	4.29	Yes	No	0	7	5
68	R:R:G80	R:R:S118	3.71	No	No	0	8	7
69	R:R:H81	R:R:Q297	3.71	Yes	Yes	1	8	8
70	R:R:H81	R:R:I298	5.3	Yes	Yes	1	8	8
71	R:R:F111	R:R:N84	4.83	Yes	Yes	1	6	6
72	R:R:C114	R:R:N84	4.72	No	Yes	0	4	6
73	R:R:M115	R:R:N84	7.01	No	Yes	1	8	6
74	R:R:N84	R:R:S118	7.45	Yes	No	0	6	7
75	R:R:I87	R:R:L107	4.28	No	No	0	6	5
76	R:R:F111	R:R:I87	15.07	Yes	No	0	6	6
77	R:R:F90	R:R:S94	7.93	No	No	0	5	4
78	R:R:V91	R:R:W98	9.81	No	Yes	0	7	5
79	R:R:K96	R:R:Y92	5.97	No	Yes	1	5	8
80	R:R:T184	R:R:Y92	8.74	Yes	Yes	1	9	8
81	R:R:D95	R:R:E97	6.5	No	No	0	4	4
82	R:R:K96	R:R:T184	4.5	No	Yes	1	5	9
83	R:R:E97	R:R:R100	22.1	No	No	4	4	1
84	R:R:E97	R:R:F101	10.49	No	No	4	4	4
85	R:R:D102	R:R:W98	4.47	No	Yes	0	4	5
86	R:R:C108	R:R:W98	5.22	No	Yes	1	9	5
87	R:R:I179	R:R:W98	18.79	No	Yes	1	5	5
88	R:R:R183	R:R:W98	9	No	Yes	0	6	5
89	R:R:C186	R:R:W98	6.53	Yes	Yes	1	9	5
90	R:R:I99	R:R:R100	3.76	No	No	0	1	1
91	R:R:F101	R:R:R100	5.34	No	No	4	4	1
92	R:R:D102	R:R:L107	6.79	No	No	0	4	5
93	R:R:S104	R:R:V106	4.85	No	No	0	5	3
94	R:R:C108	R:R:C186	7.28	No	Yes	1	9	9
95	R:R:F111	R:R:M115	4.98	Yes	No	1	6	8
96	R:R:C186	R:R:F111	4.19	Yes	Yes	1	9	6
97	R:R:G112	R:R:Y177	10.14	No	Yes	0	7	7
98	R:R:I113	R:R:L168	4.28	No	No	0	5	4
99	R:R:V116	R:R:Y177	5.05	No	Yes	1	8	7
100	R:R:V116	R:R:Y188	6.31	No	Yes	1	8	6
101	R:R:C121	R:R:F117	6.98	Yes	No	0	7	7
102	R:R:F117	R:R:V164	3.93	No	No	0	7	4
103	R:R:I166	R:R:L120	4.28	Yes	Yes	1	6	6
104	R:R:F205	R:R:L120	3.65	No	Yes	1	8	6
105	R:R:L120	R:R:L208	4.15	Yes	Yes	1	6	5
106	R:R:A163	R:R:C121	3.61	No	Yes	0	7	7
107	R:R:P122	R:R:Q297	9.47	No	Yes	1	9	8
108	R:R:L123	R:R:W262	22.78	No	Yes	0	7	9
109	R:R:L125	R:R:V159	4.47	No	No	0	7	5
110	R:R:M155	R:R:V128	7.61	No	No	0	5	7
111	R:R:M129	R:R:Y304	11.97	Yes	No	1	9	9
112	R:R:A130	R:R:N220	4.69	No	No	0	9	9
113	R:R:E132	R:R:R133	5.82	Yes	Yes	2	9	9
114	R:R:E132	R:R:H143	6.15	Yes	Yes	2	9	8
115	R:R:M247	R:R:R133	7.44	No	Yes	2	8	9
116	R:R:Q250	R:R:R133	10.51	Yes	Yes	2	8	9
117	R:R:C134	R:R:C219	3.64	Yes	No	0	6	7
118	R:R:G136	R:R:H143	6.35	No	Yes	0	8	8
119	R:R:T223	R:R:V137	4.76	Yes	No	0	8	8
120	R:R:L227	R:R:V137	4.47	No	No	0	8	8
121	R:R:T138	R:R:T226	4.71	No	No	0	7	6
122	R:R:F142	R:R:K146	8.69	No	No	0	4	4
123	R:R:F142	R:R:I147	3.77	No	Yes	0	4	5
124	R:R:H143	R:R:I147	3.98	Yes	Yes	2	8	5
125	R:R:K146	R:R:T145	9.01	No	No	0	4	5
126	R:R:K150	R:R:T148	7.51	No	No	2	5	7
127	R:R:H151	R:R:T148	8.21	No	No	2	5	7
128	R:R:H151	R:R:K150	10.48	No	No	2	5	5
129	R:R:M155	R:R:V159	4.56	No	No	0	5	5
130	R:R:F162	R:R:I166	6.28	No	Yes	0	4	6
131	R:R:F165	R:R:I166	3.77	No	Yes	0	3	6
132	R:R:I166	R:R:L208	4.28	Yes	Yes	1	6	5
133	R:R:P170	R:R:Y177	13.91	No	Yes	1	9	7
134	R:R:P170	R:R:Y188	6.95	No	Yes	1	9	6
135	R:R:P170	R:R:Y201	6.95	No	Yes	1	9	6
136	R:R:D195	R:R:R175	9.53	No	No	1	1	8
137	R:R:E197	R:R:R175	5.82	No	No	1	2	8
138	R:R:Y177	R:R:Y188	12.91	Yes	Yes	1	7	6
139	R:R:K178	R:R:N189	8.39	No	No	0	5	6
140	R:R:C186	R:R:I179	4.91	Yes	No	1	9	5
141	R:R:Q180	R:R:W185	15.33	No	Yes	1	8	8
142	R:R:F187	R:R:Q180	4.68	Yes	No	1	8	8
143	R:R:Q180	R:R:T190	5.67	No	Yes	0	8	7
144	R:R:A181	R:R:C283	3.61	No	No	0	4	4
145	R:R:S182	R:R:W185	3.71	No	Yes	0	8	8
146	R:R:L287	R:R:S182	6.01	No	No	0	6	8
147	R:R:T184	R:R:W185	6.06	Yes	Yes	1	9	8
148	R:R:F187	R:R:W185	9.02	Yes	Yes	1	8	8
149	R:R:F265	R:R:W185	4.01	Yes	Yes	1	8	8
150	R:R:L290	R:R:W185	14.81	No	Yes	1	7	8
151	R:R:F187	R:R:Y188	13.41	Yes	Yes	1	8	6
152	R:R:F187	R:R:F205	11.79	Yes	No	1	8	8
153	R:R:F187	R:R:F265	5.36	Yes	Yes	1	8	8
154	R:R:Y188	R:R:Y201	5.96	Yes	Yes	1	6	6
155	R:R:L202	R:R:Y188	4.69	No	Yes	0	6	6
156	R:R:F205	R:R:Y188	7.22	No	Yes	1	8	6
157	R:R:D198	R:R:N189	5.39	No	No	0	5	6
158	R:R:E191	R:R:T190	8.47	No	Yes	0	3	7
159	R:R:L202	R:R:T190	5.9	No	Yes	0	6	7
160	R:R:I272	R:R:T190	7.6	No	Yes	0	6	7
161	R:R:D192	R:R:N277	4.04	No	No	0	2	1
162	R:R:D198	R:R:I193	9.8	No	No	0	5	1
163	R:R:I193	R:R:R199	6.26	No	No	0	1	3
164	R:R:G276	R:R:I193	3.53	No	No	0	1	1
165	R:R:D195	R:R:W196	4.47	No	No	1	1	1
166	R:R:D195	R:R:E197	9.09	No	No	1	1	2
167	R:R:E197	R:R:W196	16.36	No	No	1	2	1
168	R:R:F200	R:R:Y201	4.13	No	Yes	0	5	6
169	R:R:F200	R:R:L204	4.87	No	No	0	5	4
170	R:R:L204	R:R:L208	4.15	No	Yes	0	4	5
171	R:R:F207	R:R:L211	3.65	No	No	0	4	4
172	R:R:G209	R:R:L266	5.13	No	No	0	7	7
173	R:R:L210	R:R:L266	6.92	No	No	0	5	7
174	R:R:L213	R:R:S258	4.5	No	No	0	8	9
175	R:R:C259	R:R:L213	4.76	No	No	0	5	8
176	R:R:L217	R:R:M255	4.24	No	No	0	5	8
177	R:R:C259	R:R:L217	4.76	No	No	0	5	5
178	R:R:M255	R:R:N220	5.61	No	No	0	8	9
179	R:R:H244	R:R:L227	3.86	No	No	0	8	8
180	R:R:L228	R:R:V248	4.47	No	No	0	5	7
181	R:R:H244	R:R:V230	6.92	No	No	0	8	7
182	R:R:F232	R:R:K231	4.96	No	No	0	5	6
183	R:R:H244	R:R:K231	10.48	No	No	0	8	6
184	R:R:H243	R:R:S242	4.18	No	No	0	5	6
185	R:R:E246	R:R:R308	4.65	No	No	0	7	9
186	R:R:E246	R:R:K309	28.35	No	No	0	7	7
187	R:R:M247	R:R:Q250	4.08	No	Yes	2	8	8
188	R:R:L251	R:R:M247	5.65	No	No	0	8	8
189	R:R:I254	R:R:Q250	4.12	No	Yes	0	8	8
190	R:R:Q250	R:R:R308	23.36	Yes	No	0	8	9
191	R:R:I254	R:R:Y304	16.92	No	No	0	8	9
192	R:R:L299	R:R:V257	5.96	No	No	0	7	7
193	R:R:F265	R:R:W262	4.01	Yes	Yes	1	8	9
194	R:R:L266	R:R:W262	5.69	No	Yes	0	7	9
195	R:R:A293	R:R:W262	9.08	No	Yes	0	8	9
196	R:R:N296	R:R:W262	10.17	Yes	Yes	1	9	9
197	R:R:Q297	R:R:W262	7.67	Yes	Yes	1	8	9
198	R:R:F265	R:R:M269	9.95	Yes	No	0	8	7
199	R:R:F265	R:R:L290	6.09	Yes	No	1	8	7
200	R:R:E281	R:R:T268	9.88	Yes	No	0	1	5
201	R:R:T268	R:R:T286	4.71	No	No	0	5	7
202	R:R:N271	R:R:N275	6.81	No	No	3	4	1
203	R:R:N271	R:R:S279	8.94	No	No	3	4	1
204	R:R:E281	R:R:N271	15.77	Yes	No	3	1	4
205	R:R:E281	R:R:I272	17.76	Yes	No	0	1	6
206	R:R:I274	R:R:N275	4.25	No	No	0	3	1
207	R:R:N275	R:R:S279	5.96	No	No	3	1	1
208	R:R:E281	R:R:S279	5.75	Yes	No	3	1	1
209	R:R:T282	R:R:T285	4.71	No	No	0	4	2
210	R:R:L287	R:R:R291	9.72	No	Yes	0	6	8
211	R:R:F288	R:R:M292	7.46	No	No	0	4	6
212	R:R:T294	R:R:W295	3.64	No	No	1	9	5
213	R:R:I298	R:R:W295	15.27	Yes	No	1	8	5
214	R:R:N296	R:R:Q297	7.92	Yes	Yes	1	9	8
215	R:R:D300	R:R:N296	8.08	No	Yes	1	9	9
216	R:R:L306	R:R:W302	18.22	No	No	0	8	6
217	R:R:L307	R:R:W302	5.69	No	No	0	6	6
218	R:R:K317	R:R:Q321	14.92	No	No	0	4	3
219	R:R:G85	R:R:M37	3.49	No	No	0	7	7
220	R:R:C283	R:R:S182	3.44	No	No	0	4	8
221	R:R:G72	R:R:L156	3.42	No	No	0	8	7
222	R:R:A212	R:R:S127	3.42	No	No	0	7	7
223	R:R:A130	R:R:S216	3.42	No	No	0	9	8
224	R:R:G273	R:R:L202	3.42	No	No	0	4	6
225	R:R:G273	R:R:L203	3.42	No	No	0	4	4
226	R:R:A270	R:R:S206	3.42	No	No	0	5	7
227	R:R:A47	R:R:V74	3.39	No	No	0	9	8
228	R:R:A167	R:R:V116	3.39	No	No	0	8	8
229	R:R:C134	R:R:T138	3.38	Yes	No	0	6	7
230	R:R:C134	R:R:T223	3.38	Yes	Yes	0	6	8
231	R:R:M292	R:R:P264	3.35	No	No	0	6	9
232	L:L:?1	R:R:G119	3.33	Yes	No	0	0	7
233	R:R:C114	R:R:I83	3.27	No	No	0	4	5
234	R:R:C219	R:R:I131	3.27	No	No	0	7	6
235	R:R:C134	R:R:I222	3.27	Yes	No	0	6	4
236	R:R:A167	R:R:I113	3.25	No	No	0	8	5
237	R:R:S127	R:R:V215	3.23	No	No	0	7	5
238	R:R:V257	R:R:V303	3.21	No	No	0	7	8
239	R:R:C121	R:R:L125	3.17	Yes	No	0	7	7
240	R:R:A70	R:R:L51	3.15	No	No	0	8	8
241	R:R:C261	R:R:N296	3.15	No	Yes	0	8	9
242	R:R:I298	R:R:V39	3.07	Yes	No	0	8	6
243	R:R:I50	R:R:V311	3.07	No	No	0	8	7
244	R:R:I110	R:R:V106	3.07	No	No	0	5	3
245	R:R:I131	R:R:V215	3.07	No	No	0	6	5
246	R:R:I254	R:R:V303	3.07	No	No	0	8	8
247	R:R:I141	R:R:T145	3.04	No	No	0	5	5
248	R:R:K139	R:R:T138	3	No	No	0	5	7
249	R:R:L203	R:R:S206	3	No	No	0	4	7
250	R:R:L227	R:R:V248	2.98	No	No	0	8	7
251	R:R:N296	R:R:S258	2.98	Yes	No	0	9	9
252	R:R:L315	R:R:V311	2.98	No	No	0	4	7
253	R:R:L42	R:R:T38	2.95	No	No	0	4	5
254	R:R:L251	R:R:T223	2.95	No	Yes	0	8	8
255	R:R:I113	R:R:I171	2.94	No	No	0	5	4
256	R:R:Q103	R:R:S104	2.89	No	No	0	4	5
257	R:R:I41	R:R:L82	2.85	No	No	0	6	5
258	R:R:I222	R:R:L218	2.85	No	No	0	4	3
259	R:R:L156	R:R:L69	2.77	No	Yes	0	7	7
260	R:R:L120	R:R:L124	2.77	Yes	No	0	6	5
261	R:R:A289	R:R:F265	2.77	No	Yes	0	7	8
262	R:R:F78	R:R:S45	2.64	Yes	No	0	7	5
263	R:R:E191	R:R:N189	2.63	No	No	0	3	6
264	R:R:D192	R:R:E191	2.6	No	No	0	2	3
265	R:R:F142	R:R:I135	2.51	No	No	0	4	5
266	R:R:F58	R:R:K61	2.48	No	No	0	4	5
267	R:R:F90	R:R:L107	2.44	No	No	0	5	5
268	R:R:F165	R:R:L169	2.44	No	No	0	3	6
269	R:R:F207	R:R:L208	2.44	No	Yes	0	4	5
270	R:R:E284	R:R:R27	2.33	No	No	0	1	2
271	R:R:R175	R:R:Y201	2.06	No	Yes	1	8	6
272	R:R:A289	R:R:P264	1.87	No	No	0	7	9
273	R:R:G158	R:R:S157	1.86	No	No	0	1	3
274	R:R:C121	R:R:C160	1.82	Yes	No	0	7	6
275	R:R:G224	R:R:T223	1.82	No	Yes	0	7	8
276	R:R:P264	R:R:S263	1.78	No	No	0	9	5
277	R:R:G126	R:R:M129	1.75	No	Yes	0	8	9
278	R:R:G214	R:R:L213	1.71	No	No	0	3	8
279	R:R:A253	R:R:V303	1.7	No	No	0	5	8
280	R:R:K139	R:R:P140	1.67	No	No	0	5	8
281	R:R:C114	R:R:I110	1.64	No	No	0	4	5
282	R:R:C256	R:R:I260	1.64	No	No	0	5	5
283	R:R:S33	R:R:V89	1.62	No	No	0	7	6
284	R:R:V30	R:R:V34	1.6	No	No	0	6	4
285	R:R:V34	R:R:V89	1.6	No	No	0	4	6
286	R:R:T38	R:R:V34	1.59	No	No	0	5	4
287	R:R:G173	R:R:H174	1.59	No	No	0	7	4
288	R:R:A54	R:R:L67	1.58	No	Yes	0	7	8
289	R:R:I171	R:R:S109	1.55	No	No	0	4	4
290	R:R:I35	R:R:V39	1.54	No	No	0	4	6
291	R:R:K153	R:R:S149	1.53	No	No	0	5	3
292	R:R:K317	R:R:S320	1.53	No	No	0	4	5
293	R:R:L252	R:R:V248	1.49	No	No	0	5	7
294	R:R:D176	R:R:S109	1.47	No	No	0	3	4
295	R:R:G173	R:R:Y201	1.45	No	Yes	0	7	6
296	R:R:K150	R:R:M154	1.44	No	No	0	5	3
297	R:R:E284	R:R:T282	1.41	No	No	0	1	4
298	R:R:L228	R:R:L245	1.38	No	No	0	5	4
299	R:R:L307	R:R:L312	1.38	No	No	0	6	7
300	R:R:K53	R:R:Q56	1.36	No	No	0	4	4
301	R:R:H151	R:R:I147	1.33	No	Yes	2	5	5
302	R:R:F32	R:R:S29	1.32	No	No	0	4	7
303	R:R:H278	R:R:N277	1.28	No	No	0	1	1
304	R:R:Q60	R:R:R59	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.96769	13	1	0
2	R:R:N44	7.625	4	0	9
3	R:R:K63	7.4625	4	2	6
4	R:R:S65	7.35	4	2	7
5	R:R:L67	3.37	4	0	8
6	R:R:L69	4.5475	4	0	7
7	R:R:L73	5.928	5	1	9
8	R:R:D77	6.892	5	1	9
9	R:R:F78	4.195	4	0	7
10	R:R:H81	6.51	4	1	8
11	R:R:N84	6.0025	4	1	6
12	R:R:Y92	7.286	5	1	8
13	R:R:W98	8.97	6	1	5
14	R:R:F111	7.2675	4	1	6
15	R:R:L120	3.7125	4	1	6
16	R:R:C121	4.468	5	0	7
17	R:R:M129	6.255	4	1	9
18	R:R:E132	6.632	5	2	9
19	R:R:R133	9.685	4	2	9
20	R:R:C134	3.4175	4	0	6
21	R:R:H143	7.328	5	2	8
22	R:R:I147	3.725	4	2	5
23	R:R:I166	4.6525	4	1	6
24	R:R:Y177	10.5025	4	1	7
25	R:R:T184	6.2575	4	1	9
26	R:R:W185	8.82333	6	1	8
27	R:R:C186	5.7275	4	1	9
28	R:R:F187	8.852	5	1	8
29	R:R:Y188	8.20714	7	1	6
30	R:R:T190	6.91	4	0	7
31	R:R:Y201	4.11	5	1	6
32	R:R:L208	3.755	4	1	5
33	R:R:T223	3.2275	4	0	8
34	R:R:Q250	10.5175	4	2	8
35	R:R:W262	9.64571	7	1	9
36	R:R:F265	5.72571	7	1	8
37	R:R:E281	12.29	4	3	1
38	R:R:R291	8.95	4	1	8
39	R:R:N296	6.46	5	1	9
40	R:R:Q297	7.10667	6	1	8
41	R:R:I298	6.8525	4	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q297	67.425	6.04	Yes	Yes	1	0	8
2	R:R:D77	R:R:Q297	100	7.83	Yes	Yes	1	9	8
3	R:R:D77	R:R:N44	26.7248	6.73	Yes	Yes	0	9	9
4	R:R:N44	R:R:P301	11.7943	13.03	Yes	No	0	9	9
5	R:R:P301	R:R:S43	10.6071	3.56	No	No	0	9	9
6	R:R:D77	R:R:L73	85.4587	8.14	Yes	Yes	1	9	9
7	R:R:L73	R:R:M129	57.2568	5.65	Yes	Yes	1	9	9
8	R:R:L69	R:R:M129	55.4292	5.65	Yes	Yes	0	7	9
9	R:R:E132	R:R:L69	34.2647	5.3	Yes	Yes	0	9	7
10	R:R:L69	R:R:V152	20.0712	4.47	Yes	No	0	7	7
11	R:R:L68	R:R:V152	15.4717	4.47	No	No	0	6	7
12	R:R:L68	R:R:Y55	13.9367	10.55	No	No	0	6	6
13	R:R:E132	R:R:H143	20.662	6.15	Yes	Yes	2	9	8
14	R:R:H143	R:R:I147	14.2431	3.98	Yes	Yes	2	8	5
15	R:R:L125	R:R:L73	14.5468	5.54	No	Yes	0	7	9
16	R:R:N296	R:R:W262	30.5486	10.17	Yes	Yes	1	9	9
17	R:R:D300	R:R:N296	29.712	8.08	No	Yes	1	9	9
18	R:R:L73	R:R:Y304	45.896	3.52	Yes	No	1	9	9
19	L:L:?1	R:R:M115	20.8498	7.33	Yes	No	1	0	8
20	R:R:F111	R:R:M115	11.6838	4.98	Yes	No	1	6	8
21	L:L:?1	R:R:T184	12.6612	5.73	Yes	Yes	1	0	9
22	L:L:?1	R:R:F265	42.4726	7.89	Yes	Yes	1	0	8
23	R:R:F187	R:R:F265	66.8921	5.36	Yes	Yes	1	8	8
24	R:R:F187	R:R:Y188	30.5237	13.41	Yes	Yes	1	8	6
25	R:R:F187	R:R:F205	13.332	11.79	Yes	No	1	8	8
26	R:R:F205	R:R:L120	13.2685	3.65	No	Yes	1	8	6
27	R:R:I254	R:R:Y304	45.134	16.92	No	No	0	8	9
28	R:R:I254	R:R:Q250	39.4053	4.12	No	Yes	0	8	8
29	R:R:M247	R:R:Q250	33.1935	4.08	No	Yes	2	8	8
30	R:R:L251	R:R:M247	35.576	5.65	No	No	0	8	8
31	R:R:L251	R:R:T223	34.2288	2.95	No	Yes	0	8	8
32	R:R:C134	R:R:T223	17.6555	3.38	Yes	Yes	0	6	8
33	R:R:T223	R:R:V137	14.6296	4.76	Yes	No	0	8	8
34	R:R:L227	R:R:V137	13.3127	4.47	No	No	0	8	8
35	R:R:Y188	R:R:Y201	12.9925	5.96	Yes	Yes	1	6	6
36	R:R:T184	R:R:W185	13.1636	6.06	Yes	Yes	1	9	8
37	R:R:Q180	R:R:W185	45.6034	15.33	No	Yes	1	8	8
38	R:R:Q180	R:R:T190	67.4636	5.67	No	Yes	0	8	7
39	R:R:E191	R:R:T190	33.4309	8.47	No	Yes	0	3	7
40	R:R:E191	R:R:N189	20.1237	2.63	No	No	0	3	6
41	R:R:F265	R:R:W185	28.685	4.01	Yes	Yes	1	8	8
42	L:L:?1	R:R:L290	12.109	5.38	Yes	No	1	0	7
43	R:R:L290	R:R:W185	11.7363	14.81	No	Yes	1	7	8
44	R:R:F187	R:R:Q180	24.9413	4.68	Yes	No	1	8	8
45	R:R:D198	R:R:N189	13.437	5.39	No	No	0	5	6
46	R:R:I272	R:R:T190	33.4309	7.6	No	Yes	0	6	7
47	R:R:D192	R:R:E191	10.0853	2.6	No	No	0	2	3
48	R:R:D198	R:R:I193	10.0853	9.8	No	No	0	5	1
49	R:R:E281	R:R:I272	30.1124	17.76	Yes	No	0	1	6
50	R:R:E281	R:R:N271	10.0605	15.77	Yes	No	3	1	4
51	R:R:E281	R:R:S279	10.0605	5.75	Yes	No	3	1	1
52	R:R:Q297	R:R:W262	32.6275	7.67	Yes	Yes	1	8	9
53	R:R:F265	R:R:W262	59.1867	4.01	Yes	Yes	1	8	9
54	R:R:D300	R:R:L73	28.627	6.79	No	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S33	5.84	1	Yes	No	0	7	0	1
L:L:?1	R:R:H81	7.5	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:A88	4.08	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y92	6.84	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M115	7.33	1	Yes	No	0	8	0	1
L:L:?1	R:R:T184	5.73	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:W262	8.12	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F265	7.89	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L290	5.38	1	Yes	No	0	7	0	1
L:L:?1	R:R:R291	4.72	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T294	4.78	1	Yes	No	0	9	0	1
L:L:?1	R:R:Q297	6.04	1	Yes	Yes	0	8	0	1
R:R:F32	R:R:R27	4.28	1	No	No	4	2	2	2
R:R:R27	R:R:R291	7.46	1	No	Yes	2	8	2	1
R:R:L28	R:R:Y92	3.52	0	No	Yes	4	8	2	1
R:R:L28	R:R:L287	4.15	0	No	No	4	6	2	2
R:R:V30	R:R:Y92	11.36	0	No	Yes	6	8	2	1
R:R:F32	R:R:R291	13.9	1	No	Yes	4	8	2	1
R:R:F36	R:R:T294	6.49	1	No	No	8	9	2	1
R:R:F36	R:R:W295	14.03	1	No	No	8	5	2	2
R:R:F36	R:R:I298	3.77	1	No	Yes	8	8	2	2
R:R:G40	R:R:H81	9.53	0	No	Yes	9	8	2	1
R:R:D77	R:R:P122	6.44	1	Yes	No	9	9	2	2
R:R:D77	R:R:Q297	7.83	1	Yes	Yes	9	8	2	1
R:R:H81	R:R:Q297	3.71	1	Yes	Yes	8	8	1	1
R:R:H81	R:R:I298	5.3	1	Yes	Yes	8	8	1	2
R:R:F111	R:R:N84	4.83	1	Yes	Yes	6	6	2	2
R:R:M115	R:R:N84	7.01	1	No	Yes	8	6	1	2
R:R:K96	R:R:Y92	5.97	1	No	Yes	5	8	2	1
R:R:T184	R:R:Y92	8.74	1	Yes	Yes	9	8	1	1
R:R:K96	R:R:T184	4.5	1	No	Yes	5	9	2	1
R:R:F111	R:R:M115	4.98	1	Yes	No	6	8	2	1
R:R:P122	R:R:Q297	9.47	1	No	Yes	9	8	2	1
R:R:L123	R:R:W262	22.78	0	No	Yes	7	9	2	1
R:R:T184	R:R:W185	6.06	1	Yes	Yes	9	8	1	2
R:R:F187	R:R:W185	9.02	1	Yes	Yes	8	8	2	2
R:R:F265	R:R:W185	4.01	1	Yes	Yes	8	8	1	2
R:R:L290	R:R:W185	14.81	1	No	Yes	7	8	1	2
R:R:F187	R:R:F265	5.36	1	Yes	Yes	8	8	2	1
R:R:F265	R:R:W262	4.01	1	Yes	Yes	8	9	1	1
R:R:L266	R:R:W262	5.69	0	No	Yes	7	9	2	1
R:R:A293	R:R:W262	9.08	0	No	Yes	8	9	2	1
R:R:N296	R:R:W262	10.17	1	Yes	Yes	9	9	2	1
R:R:Q297	R:R:W262	7.67	1	Yes	Yes	8	9	1	1
R:R:F265	R:R:M269	9.95	1	Yes	No	8	7	1	2
R:R:F265	R:R:L290	6.09	1	Yes	No	8	7	1	1
R:R:L287	R:R:R291	9.72	0	No	Yes	6	8	2	1
R:R:T294	R:R:W295	3.64	1	No	No	9	5	1	2
R:R:I298	R:R:W295	15.27	1	Yes	No	8	5	2	2
R:R:N296	R:R:Q297	7.92	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:G119	3.33	1	Yes	No	0	7	0	1
R:R:A289	R:R:F265	2.77	0	No	Yes	7	8	2	1
R:R:S33	R:R:V89	1.62	0	No	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XJM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	265
Number of Links	304
Number of Hubs	41
Number of Links mediated by Hubs	153
Number of Communities	4
Number of Nodes involved in Communities	65
Number of Links involved in Communities	99

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	69744
Length Of Smallest Path	3
Average Path Length	12.9311
Length of Longest Path	25
Minimum Path Strength	1.51
Average Path Strength	6.54368
Maximum Path Strength	18.7867
Minimum Path Correlation	0.7
Average Path Correlation	0.92841
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	49.2604
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.8448
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7WT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7WT
Name	Latanoprost acid
Synonyms	7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]hept-5-enoic acid
Identifier
Formula	C23 H34 O5
Molecular Weight	390.513
SMILES
PubChem	6441636
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	5
Total Bonds	63
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43088
Sequence	>8XJM_nogp_Chain_R N R L S V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q K S K A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D K E W I R F D Q S N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K P I F H S T K I T S K H V K M M L S G V C L F A V F I A L L P I L G H R D Y K I Q A S R T W C F Y N T E D I K D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N G N H S L E T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A V L K N L Y K L A S Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XJK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-		2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.85	2024-02-28	To be published
	8XJM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.85	2024-02-28	To be published
	8XJL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.77	2024-02-28	To be published
	8XJL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.77	2024-02-28	To be published
	8IQ6	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ6 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-		2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IUM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-		3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.67	2023-07-12	10.1038/s41467-023-38411-x
	8IUK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.67	2023-07-12	10.1038/s41467-023-38411-x

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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