psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S33	4.09	Yes	No	0	0	7
2	L:L:?1	R:R:H81	24.5	Yes	Yes	1	0	8
3	L:L:?1	R:R:N84	13.08	Yes	No	1	0	6
4	L:L:?1	R:R:M115	4.81	Yes	No	1	0	8
5	L:L:?1	R:R:S118	8.17	Yes	Yes	1	0	7
6	L:L:?1	R:R:G119	3.49	Yes	No	1	0	7
7	L:L:?1	R:R:T184	6.02	Yes	No	0	0	9
8	L:L:?1	R:R:F265	4.14	Yes	No	0	0	8
9	L:L:?1	R:R:L290	5.65	Yes	No	0	0	7
10	L:L:?1	R:R:R291	6.61	Yes	No	0	0	8
11	L:L:?1	R:R:T294	11.03	Yes	No	1	0	9
12	L:L:?1	R:R:Q297	8.15	Yes	Yes	1	0	8
13	R:R:S29	R:R:Y92	5.09	No	Yes	0	7	8
14	R:R:F31	R:R:V30	3.93	No	No	0	4	6
15	R:R:V30	R:R:Y92	10.09	No	Yes	0	6	8
16	R:R:M37	R:R:V34	3.04	No	No	0	7	4
17	R:R:F36	R:R:W295	12.03	No	No	0	8	5
18	R:R:I41	R:R:M37	2.92	Yes	No	0	6	7
19	R:R:G85	R:R:M37	3.49	No	No	0	7	7
20	R:R:L42	R:R:T38	2.95	No	No	0	4	5
21	R:R:I298	R:R:V39	4.61	Yes	No	0	8	6
22	R:R:G40	R:R:S43	3.71	No	No	0	9	9
23	R:R:G40	R:R:I298	3.53	No	Yes	0	9	8
24	R:R:F78	R:R:I41	10.05	No	Yes	0	7	6
25	R:R:S43	R:R:W302	9.88	No	No	0	9	6
26	R:R:N44	R:R:V74	5.91	No	No	0	9	8
27	R:R:F78	R:R:N44	10.87	No	No	0	7	9
28	R:R:L306	R:R:L46	4.15	No	No	0	8	5
29	R:R:A47	R:R:V74	5.09	No	No	0	9	8
30	R:R:I48	R:R:M52	4.37	No	No	0	7	4
31	R:R:I48	R:R:V74	4.61	No	No	0	7	8
32	R:R:I48	R:R:I75	2.94	No	No	0	7	6
33	R:R:I305	R:R:I50	2.94	No	Yes	0	8	8
34	R:R:I50	R:R:V311	9.22	Yes	No	7	8	7
35	R:R:I50	R:R:L315	2.85	Yes	No	7	8	4
36	R:R:A70	R:R:L51	4.73	No	No	0	8	8
37	R:R:I305	R:R:L51	9.99	No	No	0	8	8
38	R:R:A54	R:R:L67	3.15	No	No	0	7	8
39	R:R:R59	R:R:Y55	9.26	No	Yes	0	5	6
40	R:R:L68	R:R:Y55	8.21	No	Yes	0	6	6
41	R:R:F58	R:R:L67	3.65	No	No	0	4	8
42	R:R:I147	R:R:K63	2.91	No	No	0	5	6
43	R:R:L69	R:R:S65	3	Yes	No	6	7	7
44	R:R:E132	R:R:S65	7.19	Yes	No	6	9	7
45	R:R:S65	R:R:V152	8.08	No	No	6	7	7
46	R:R:F66	R:R:M129	6.22	No	No	0	7	9
47	R:R:F66	R:R:R133	4.28	No	Yes	0	7	9
48	R:R:L68	R:R:S71	3	No	No	0	6	6
49	R:R:E132	R:R:L69	3.98	Yes	Yes	6	9	7
50	R:R:L69	R:R:V152	4.47	Yes	No	6	7	7
51	R:R:G72	R:R:S71	3.71	No	No	0	8	6
52	R:R:D77	R:R:L73	5.43	No	No	0	9	9
53	R:R:L125	R:R:L73	5.54	No	No	0	7	9
54	R:R:F117	R:R:T76	3.89	No	No	1	7	8
55	R:R:C121	R:R:T76	6.76	Yes	No	1	7	8
56	R:R:D77	R:R:P122	14.49	No	No	1	9	9
57	R:R:D77	R:R:Q297	9.14	No	Yes	1	9	8
58	R:R:F78	R:R:F79	5.36	No	No	0	7	5
59	R:R:H81	R:R:T294	4.11	Yes	No	1	8	9
60	R:R:H81	R:R:Q297	3.71	Yes	Yes	1	8	8
61	R:R:I83	R:R:I87	2.94	No	No	0	5	6
62	R:R:C114	R:R:I83	4.91	No	No	0	4	5
63	R:R:F111	R:R:N84	6.04	No	No	1	6	6
64	R:R:M115	R:R:N84	9.82	No	No	1	8	6
65	R:R:F111	R:R:I87	22.61	No	No	0	6	6
66	R:R:F101	R:R:F90	10.72	Yes	No	4	4	5
67	R:R:V91	R:R:W98	11.03	No	Yes	4	7	5
68	R:R:F101	R:R:V91	5.24	Yes	No	4	4	7
69	R:R:K96	R:R:Y92	5.97	No	Yes	0	5	8
70	R:R:T184	R:R:Y92	7.49	No	Yes	0	9	8
71	R:R:R100	R:R:S94	7.91	No	No	0	1	4
72	R:R:F101	R:R:S94	5.28	Yes	No	0	4	4
73	R:R:E97	R:R:R100	3.49	No	No	0	4	1
74	R:R:F101	R:R:W98	8.02	Yes	Yes	4	4	5
75	R:R:I179	R:R:W98	9.4	No	Yes	4	5	5
76	R:R:R183	R:R:W98	4	No	Yes	4	6	5
77	R:R:D102	R:R:N105	5.39	No	No	0	4	1
78	R:R:C108	R:R:C186	7.28	No	No	0	9	9
79	R:R:I171	R:R:S109	3.1	No	No	0	4	4
80	R:R:D176	R:R:S109	2.94	No	No	0	3	4
81	R:R:F111	R:R:M115	9.95	No	No	1	6	8
82	R:R:G112	R:R:Y177	8.69	No	Yes	0	7	7
83	R:R:I113	R:R:L168	2.85	No	No	0	5	4
84	R:R:I113	R:R:I171	4.42	No	No	2	5	4
85	R:R:I113	R:R:Y177	3.63	No	Yes	2	5	7
86	R:R:A167	R:R:V116	3.39	No	Yes	0	8	8
87	R:R:V116	R:R:Y177	5.05	Yes	Yes	2	8	7
88	R:R:F187	R:R:V116	3.93	Yes	Yes	2	8	8
89	R:R:V116	R:R:Y188	11.36	Yes	Yes	2	8	6
90	R:R:C121	R:R:F117	5.59	Yes	No	1	7	7
91	R:R:G119	R:R:S118	3.71	No	Yes	1	7	7
92	R:R:Q297	R:R:S118	4.33	Yes	Yes	1	8	7
93	R:R:F205	R:R:L120	7.31	No	No	0	8	6
94	R:R:L120	R:R:L208	4.15	No	No	0	6	5
95	R:R:C121	R:R:P122	3.77	Yes	No	1	7	9
96	R:R:C121	R:R:L125	3.17	Yes	No	0	7	7
97	R:R:P122	R:R:Q297	11.05	No	Yes	1	9	8
98	R:R:L123	R:R:W262	22.78	No	No	0	7	9
99	R:R:L124	R:R:V159	2.98	No	Yes	0	5	5
100	R:R:L125	R:R:V159	2.98	No	Yes	0	7	5
101	R:R:S127	R:R:V215	3.23	No	No	0	7	5
102	R:R:A130	R:R:S216	3.42	No	No	3	9	8
103	R:R:A130	R:R:N220	3.13	No	Yes	3	9	9
104	R:R:I131	R:R:I135	2.94	No	No	0	6	5
105	R:R:I131	R:R:V215	3.07	No	No	0	6	5
106	R:R:C219	R:R:I131	3.27	No	No	0	7	6
107	R:R:E132	R:R:H143	9.85	Yes	No	0	9	8
108	R:R:E132	R:R:V152	2.85	Yes	No	6	9	7
109	R:R:N220	R:R:R133	6.03	Yes	Yes	3	9	9
110	R:R:L251	R:R:R133	3.64	No	Yes	3	8	9
111	R:R:R133	R:R:Y304	3.09	Yes	Yes	0	9	9
112	R:R:C134	R:R:T138	3.38	Yes	No	0	6	7
113	R:R:C134	R:R:C219	3.64	Yes	No	0	6	7
114	R:R:C134	R:R:I222	3.27	Yes	No	0	6	4
115	R:R:C134	R:R:T223	3.38	Yes	Yes	0	6	8
116	R:R:G136	R:R:H143	3.18	No	No	0	8	8
117	R:R:T223	R:R:V137	4.76	Yes	No	3	8	8
118	R:R:T226	R:R:V137	3.17	No	No	0	6	8
119	R:R:L227	R:R:V137	2.98	Yes	No	3	8	8
120	R:R:K139	R:R:T138	3	No	No	0	5	7
121	R:R:F142	R:R:K139	11.17	Yes	No	0	4	5
122	R:R:F142	R:R:K146	8.69	Yes	No	0	4	4
123	R:R:F142	R:R:I147	5.02	Yes	No	0	4	5
124	R:R:H143	R:R:I147	6.63	No	No	0	8	5
125	R:R:K146	R:R:T145	4.5	No	No	0	4	5
126	R:R:H151	R:R:T148	10.95	No	No	0	5	7
127	R:R:K153	R:R:S149	6.12	No	No	0	5	3
128	R:R:K150	R:R:M154	5.76	No	No	0	5	3
129	R:R:M155	R:R:V159	3.04	No	Yes	0	5	5
130	R:R:C160	R:R:L156	3.17	No	No	0	6	7
131	R:R:F162	R:R:I166	11.3	No	No	0	4	6
132	R:R:F162	R:R:L208	6.09	No	No	0	4	5
133	R:R:L168	R:R:V164	2.98	No	No	0	4	4
134	R:R:I166	R:R:L204	2.85	No	No	0	6	4
135	R:R:L169	R:R:P170	3.28	No	Yes	2	6	9
136	R:R:L169	R:R:Y201	8.21	No	Yes	2	6	6
137	R:R:P170	R:R:Y177	13.91	Yes	Yes	2	9	7
138	R:R:P170	R:R:Y188	6.95	Yes	Yes	2	9	6
139	R:R:P170	R:R:Y201	5.56	Yes	Yes	2	9	6
140	R:R:I171	R:R:Y177	3.63	No	Yes	2	4	7
141	R:R:D195	R:R:R175	3.57	Yes	No	5	1	8
142	R:R:D198	R:R:R175	11.91	Yes	No	5	5	8
143	R:R:Y177	R:R:Y188	5.96	Yes	Yes	2	7	6
144	R:R:K178	R:R:N189	9.79	No	No	0	5	6
145	R:R:I179	R:R:R183	8.77	No	No	4	5	6
146	R:R:C186	R:R:I179	3.27	No	No	0	9	5
147	R:R:Q180	R:R:W185	10.95	No	Yes	2	8	8
148	R:R:F187	R:R:Q180	3.51	Yes	No	2	8	8
149	R:R:Q180	R:R:T190	9.92	No	No	0	8	7
150	R:R:S182	R:R:T184	6.4	No	No	0	8	9
151	R:R:S182	R:R:W185	4.94	No	Yes	0	8	8
152	R:R:F187	R:R:W185	8.02	Yes	Yes	2	8	8
153	R:R:L290	R:R:W185	6.83	No	Yes	0	7	8
154	R:R:F187	R:R:Y188	13.41	Yes	Yes	2	8	6
155	R:R:F187	R:R:F205	6.43	Yes	No	0	8	8
156	R:R:Y188	R:R:Y201	7.94	Yes	Yes	2	6	6
157	R:R:L202	R:R:Y188	4.69	No	Yes	0	6	6
158	R:R:I193	R:R:N189	4.25	Yes	No	5	1	6
159	R:R:D198	R:R:N189	6.73	Yes	No	5	5	6
160	R:R:I272	R:R:T190	3.04	Yes	No	0	6	7
161	R:R:E191	R:R:N277	7.89	No	No	0	3	1
162	R:R:D192	R:R:K194	6.91	No	No	0	2	1
163	R:R:D198	R:R:I193	4.2	Yes	Yes	5	5	1
164	R:R:D195	R:R:E197	7.8	Yes	No	0	1	2
165	R:R:D195	R:R:D198	15.97	Yes	Yes	5	1	5
166	R:R:E197	R:R:W196	18.54	No	No	0	2	1
167	R:R:F200	R:R:Y201	6.19	No	Yes	0	5	6
168	R:R:F200	R:R:L204	3.65	No	No	0	5	4
169	R:R:L202	R:R:M269	7.07	No	No	0	6	7
170	R:R:L204	R:R:L208	4.15	No	No	0	4	5
171	R:R:A270	R:R:S206	3.42	No	No	0	5	7
172	R:R:F207	R:R:L211	7.31	No	No	0	4	4
173	R:R:L210	R:R:L266	6.92	No	No	0	5	7
174	R:R:L211	R:R:V215	2.98	No	No	0	4	5
175	R:R:L213	R:R:S258	3	No	No	0	8	9
176	R:R:C259	R:R:L213	3.17	No	No	0	5	8
177	R:R:N220	R:R:S216	2.98	Yes	No	3	9	8
178	R:R:L217	R:R:M255	5.65	No	No	0	5	8
179	R:R:C259	R:R:L217	4.76	No	No	0	5	5
180	R:R:I222	R:R:L218	5.71	No	No	0	4	3
181	R:R:L251	R:R:N220	5.49	No	Yes	3	8	9
182	R:R:M255	R:R:N220	5.61	No	Yes	0	8	9
183	R:R:L227	R:R:T223	2.95	Yes	Yes	3	8	8
184	R:R:L251	R:R:T223	2.95	No	Yes	3	8	8
185	R:R:I225	R:R:R229	7.52	No	No	0	3	4
186	R:R:L227	R:R:V248	2.98	Yes	No	0	8	7
187	R:R:F232	R:R:L228	6.09	No	No	0	5	5
188	R:R:K231	R:R:R241	9.9	No	No	0	6	4
189	R:R:H244	R:R:K231	14.41	No	No	0	8	6
190	R:R:F232	R:R:R241	3.21	No	No	0	5	4
191	R:R:Q236	R:R:S234	5.78	No	No	0	3	4
192	R:R:I249	R:R:L245	5.71	No	No	0	6	4
193	R:R:E246	R:R:R308	8.14	No	No	0	7	9
194	R:R:E246	R:R:K309	14.85	No	No	0	7	7
195	R:R:L252	R:R:V248	2.98	No	No	0	5	7
196	R:R:I254	R:R:Q250	5.49	No	No	0	8	8
197	R:R:Q250	R:R:R308	21.03	No	No	0	8	9
198	R:R:I254	R:R:Y304	8.46	No	Yes	0	8	9
199	R:R:C256	R:R:I260	3.27	No	No	0	5	5
200	R:R:C261	R:R:M292	4.86	No	No	0	8	6
201	R:R:N296	R:R:W262	9.04	No	No	0	9	9
202	R:R:P264	R:R:S263	3.56	No	No	0	9	5
203	R:R:M292	R:R:P264	5.03	No	No	0	6	9
204	R:R:F265	R:R:M269	7.46	No	No	0	8	7
205	R:R:A289	R:R:F265	4.16	No	No	0	7	8
206	R:R:I272	R:R:T268	3.04	Yes	No	0	6	5
207	R:R:N271	R:R:N275	9.54	No	No	0	4	1
208	R:R:I274	R:R:N275	4.25	No	No	0	3	1
209	R:R:E281	R:R:T285	14.11	No	No	0	1	2
210	R:R:L287	R:R:R291	10.93	No	No	0	6	8
211	R:R:I298	R:R:W295	4.7	Yes	No	1	8	5
212	R:R:L299	R:R:W295	6.83	No	No	1	7	5
213	R:R:N296	R:R:Q297	3.96	No	Yes	0	9	8
214	R:R:D300	R:R:N296	4.04	No	No	0	9	9
215	R:R:I298	R:R:L299	2.85	Yes	No	1	8	7
216	R:R:D300	R:R:Y304	9.2	No	Yes	0	9	9
217	R:R:L306	R:R:W302	18.22	No	No	0	8	6
218	R:R:L307	R:R:V303	2.98	No	No	0	6	8
219	R:R:R308	R:R:V311	3.92	No	No	0	9	7
220	R:R:L315	R:R:V311	2.98	No	No	7	4	7
221	R:R:S320	R:R:Y316	5.09	No	No	0	5	4
222	R:R:E284	R:R:T282	2.82	No	No	0	1	4
223	R:R:K317	R:R:N314	2.8	No	No	0	4	5
224	R:R:H243	R:R:S242	2.79	No	No	0	5	6
225	R:R:L156	R:R:L69	2.77	No	Yes	0	7	7
226	R:R:A163	R:R:F117	2.77	No	No	0	7	7
227	R:R:I99	R:R:Q103	2.74	No	No	0	1	4
228	R:R:M247	R:R:Q250	2.72	No	No	0	8	8
229	R:R:D176	R:R:N105	2.69	No	No	0	3	1
230	R:R:A64	R:R:Y55	2.67	No	Yes	0	7	6
231	R:R:H81	R:R:I298	2.65	Yes	Yes	1	8	8
232	R:R:H151	R:R:M154	2.63	No	No	0	5	3
233	R:R:V303	R:R:Y304	2.52	No	Yes	0	8	9
234	R:R:I193	R:R:R199	2.51	Yes	No	0	1	3
235	R:R:F90	R:R:L107	2.44	No	No	4	5	5
236	R:R:F101	R:R:L107	2.44	Yes	No	4	4	5
237	R:R:T286	R:R:W185	2.43	No	Yes	0	7	8
238	R:R:L67	R:R:Y55	2.34	No	Yes	0	8	6
239	R:R:Q60	R:R:R59	2.34	No	No	0	5	5
240	R:R:L266	R:R:W262	2.28	No	No	0	7	9
241	L:L:?1	R:R:A293	2.14	Yes	No	0	0	8
242	R:R:F32	R:R:F36	2.14	No	No	0	4	8
243	R:R:F32	R:R:R291	2.14	No	No	0	4	8
244	R:R:A88	R:R:G85	1.95	No	No	0	8	7
245	R:R:A212	R:R:G209	1.95	No	Yes	0	7	7
246	R:R:A47	R:R:P301	1.87	No	No	0	9	9
247	R:R:G80	R:R:S118	1.86	No	Yes	0	8	7
248	R:R:G158	R:R:S157	1.86	No	No	0	1	3
249	R:R:G224	R:R:T223	1.82	No	Yes	0	7	8
250	R:R:A181	R:R:C283	1.81	No	No	0	4	4
251	R:R:P301	R:R:S43	1.78	No	No	0	9	9
252	R:R:G72	R:R:I75	1.76	No	No	0	8	6
253	R:R:G126	R:R:M129	1.75	No	No	0	8	9
254	R:R:G240	R:R:K231	1.74	No	No	0	4	6
255	R:R:G209	R:R:L120	1.71	Yes	No	0	7	6
256	R:R:G209	R:R:L123	1.71	Yes	No	0	7	7
257	R:R:A212	R:R:S127	1.71	No	No	0	7	7
258	R:R:G158	R:R:L161	1.71	No	No	0	1	3
259	R:R:G273	R:R:L203	1.71	No	No	0	4	4
260	R:R:G209	R:R:L266	1.71	Yes	No	0	7	7
261	R:R:G214	R:R:L213	1.71	No	No	0	3	8
262	R:R:G214	R:R:L217	1.71	No	No	0	3	5
263	R:R:C261	R:R:V257	1.71	No	No	0	8	7
264	R:R:K139	R:R:P140	1.67	No	No	0	5	8
265	R:R:C114	R:R:I110	1.64	No	No	0	4	5
266	R:R:S263	R:R:V267	1.62	No	No	0	5	6
267	R:R:A221	R:R:M255	1.61	No	No	0	4	8
268	R:R:V34	R:R:V89	1.6	No	No	0	4	6
269	R:R:V128	R:R:V159	1.6	No	Yes	0	7	5
270	R:R:G173	R:R:H174	1.59	No	No	0	7	4
271	R:R:A270	R:R:L203	1.58	No	No	0	5	4
272	R:R:T268	R:R:T285	1.57	No	No	0	5	2
273	R:R:I41	R:R:S45	1.55	Yes	No	0	6	5
274	R:R:I272	R:R:S279	1.55	Yes	No	0	6	1
275	R:R:I35	R:R:V39	1.54	No	No	0	4	6
276	R:R:I87	R:R:V91	1.54	No	No	0	6	7
277	R:R:I110	R:R:V106	1.54	No	No	0	5	3
278	R:R:K61	R:R:S62	1.53	No	No	0	5	7
279	R:R:M269	R:R:S206	1.53	No	No	0	7	7
280	R:R:K233	R:R:S234	1.53	No	No	0	5	4
281	R:R:K233	R:R:V230	1.52	No	No	0	5	7
282	R:R:G276	R:R:R199	1.5	No	No	0	1	3
283	R:R:N271	R:R:S279	1.49	No	No	0	4	1
284	R:R:I193	R:R:I272	1.47	Yes	Yes	0	1	6
285	R:R:G173	R:R:Y201	1.45	No	Yes	0	7	6
286	R:R:K309	R:R:K313	1.44	No	No	0	7	4
287	R:R:I41	R:R:L82	1.43	Yes	No	0	6	5
288	R:R:I50	R:R:N314	1.42	Yes	No	0	8	5
289	R:R:K53	R:R:L318	1.41	No	No	0	4	4
290	R:R:D195	R:R:K194	1.38	Yes	No	0	1	1
291	R:R:E97	R:R:I99	1.37	No	No	0	4	1
292	R:R:K317	R:R:Q321	1.36	No	No	0	4	3
293	R:R:D95	R:R:E97	1.3	No	No	0	4	4
294	R:R:D192	R:R:E191	1.3	No	No	0	2	3
295	R:R:H244	R:R:L227	1.29	No	Yes	0	8	8
296	R:R:H278	R:R:N275	1.28	No	No	0	1	1
297	R:R:F142	R:R:I141	1.26	Yes	No	0	4	5
298	R:R:F165	R:R:I166	1.26	No	No	0	3	6
299	R:R:F165	R:R:L172	1.22	No	No	0	3	4
300	R:R:L245	R:R:R241	1.21	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.83692	13	1	0
2	R:R:I41	3.9875	4	0	6
3	R:R:I50	4.1075	4	7	8
4	R:R:Y55	5.62	4	0	6
5	R:R:L69	3.555	4	6	7
6	R:R:H81	8.7425	4	1	8
7	R:R:Y92	7.16	4	0	8
8	R:R:W98	8.1125	4	4	5
9	R:R:F101	6.34	5	4	4
10	R:R:V116	5.9325	4	2	8
11	R:R:S118	4.5175	4	1	7
12	R:R:C121	4.8225	4	1	7
13	R:R:E132	5.9675	4	6	9
14	R:R:R133	4.26	4	3	9
15	R:R:C134	3.4175	4	0	6
16	R:R:F142	6.535	4	0	4
17	R:R:V159	2.65	4	0	5
18	R:R:P170	7.425	4	2	9
19	R:R:Y177	6.81167	6	2	7
20	R:R:W185	6.634	5	2	8
21	R:R:F187	7.06	5	2	8
22	R:R:Y188	8.385	6	2	6
23	R:R:I193	3.1075	4	5	1
24	R:R:D195	7.18	4	5	1
25	R:R:D198	9.7025	4	5	5
26	R:R:Y201	5.87	5	2	6
27	R:R:G209	1.77	4	0	7
28	R:R:N220	4.648	5	3	9
29	R:R:T223	3.172	5	3	8
30	R:R:L227	2.55	4	3	8
31	R:R:I272	2.275	4	0	6
32	R:R:Q297	6.72333	6	1	8
33	R:R:I298	3.668	5	1	8
34	R:R:Y304	5.8175	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H81	36.1619	24.5	Yes	Yes	1	0	8
2	R:R:H81	R:R:I298	65.2573	2.65	Yes	Yes	1	8	8
3	R:R:G40	R:R:I298	57.1804	3.53	No	Yes	0	9	8
4	R:R:G40	R:R:S43	55.5744	3.71	No	No	0	9	9
5	R:R:P301	R:R:S43	49.0335	1.78	No	No	0	9	9
6	R:R:A47	R:R:P301	47.369	1.87	No	No	0	9	9
7	R:R:A47	R:R:V74	45.6929	5.09	No	No	0	9	8
8	R:R:N44	R:R:V74	21.001	5.91	No	No	0	9	8
9	R:R:F78	R:R:N44	19.1497	10.87	No	No	0	7	9
10	R:R:F78	R:R:I41	15.412	10.05	No	Yes	0	7	6
11	R:R:I48	R:R:V74	24.6686	4.61	No	No	0	7	8
12	R:R:I48	R:R:I75	21.001	2.94	No	No	0	7	6
13	L:L:?1	R:R:Q297	75.0861	8.15	Yes	Yes	1	0	8
14	R:R:N296	R:R:Q297	100	3.96	No	Yes	0	9	8
15	R:R:D300	R:R:N296	85.4523	4.04	No	No	0	9	9
16	R:R:D300	R:R:Y304	84.4537	9.2	No	Yes	0	9	9
17	R:R:I254	R:R:Y304	27.8631	8.46	No	Yes	0	8	9
18	R:R:I254	R:R:Q250	26.1928	5.49	No	No	0	8	8
19	R:R:Q250	R:R:R308	22.7997	21.03	No	No	0	8	9
20	R:R:R308	R:R:V311	15.9026	3.92	No	No	0	9	7
21	R:R:I50	R:R:V311	12.4803	9.22	Yes	No	7	8	7
22	R:R:G72	R:R:I75	19.1497	1.76	No	No	0	8	6
23	R:R:G72	R:R:S71	17.2867	3.71	No	No	0	8	6
24	R:R:L68	R:R:S71	15.412	3	No	No	0	6	6
25	R:R:L68	R:R:Y55	13.5257	8.21	No	Yes	0	6	6
26	R:R:R133	R:R:Y304	64.3579	3.09	Yes	Yes	0	9	9
27	R:R:L251	R:R:R133	41.6399	3.64	No	Yes	3	8	9
28	R:R:L251	R:R:T223	43.4678	2.95	No	Yes	3	8	8
29	R:R:C134	R:R:T223	28.5055	3.38	Yes	Yes	0	6	8
30	R:R:C134	R:R:T138	26.9637	3.38	Yes	No	0	6	7
31	R:R:K139	R:R:T138	25.4511	3	No	No	0	5	7
32	R:R:F142	R:R:K139	22.3909	11.17	Yes	No	0	4	5
33	R:R:F142	R:R:I147	16.1304	5.02	Yes	No	0	4	5
34	R:R:H143	R:R:I147	13.0409	6.63	No	No	0	8	5
35	R:R:D77	R:R:Q297	12.4219	9.14	No	Yes	1	9	8
36	R:R:D77	R:R:L73	10.6874	5.43	No	No	0	9	9
37	R:R:P122	R:R:Q297	17.7481	11.05	No	Yes	1	9	8
38	R:R:C121	R:R:P122	16.0486	3.77	Yes	No	1	7	9
39	L:L:?1	R:R:N84	34.7719	13.08	Yes	No	1	0	6
40	R:R:F111	R:R:N84	33.3061	6.04	No	No	1	6	6
41	R:R:F111	R:R:I87	63.8848	22.61	No	No	0	6	6
42	R:R:I83	R:R:I87	13.1461	2.94	No	No	0	5	6
43	L:L:?1	R:R:M115	34.7895	4.81	Yes	No	1	0	8
44	R:R:F111	R:R:M115	33.3236	9.95	No	No	1	6	8
45	R:R:I87	R:R:V91	48.3502	1.54	No	No	0	6	7
46	R:R:F101	R:R:V91	29.0603	5.24	Yes	No	4	4	7
47	R:R:V91	R:R:W98	16.142	11.03	No	Yes	4	7	5
48	R:R:F101	R:R:S94	19.6519	5.28	Yes	No	0	4	4
49	R:R:R100	R:R:S94	16.4048	7.91	No	No	0	1	4
50	R:R:E97	R:R:R100	13.1461	3.49	No	No	0	4	1
51	L:L:?1	R:R:F265	28.6515	4.14	Yes	No	0	0	8
52	R:R:F265	R:R:M269	26.2571	7.46	No	No	0	8	7
53	R:R:L202	R:R:M269	22.4026	7.07	No	No	0	6	7
54	R:R:L202	R:R:Y188	21.7836	4.69	No	Yes	0	6	6
55	R:R:Y177	R:R:Y188	25.1416	5.96	Yes	Yes	2	7	6
56	R:R:I171	R:R:Y177	20.6389	3.63	No	Yes	2	4	7
57	R:R:I171	R:R:S109	16.6034	3.1	No	No	0	4	4
58	R:R:D176	R:R:S109	12.4686	2.94	No	No	0	3	4
59	L:L:?1	R:R:L290	64.9828	5.65	Yes	No	0	0	7
60	R:R:L290	R:R:W185	64.2119	6.83	No	Yes	0	7	8
61	R:R:F187	R:R:W185	40.6062	8.02	Yes	Yes	2	8	8
62	R:R:F187	R:R:Y188	30.1991	13.41	Yes	Yes	2	8	6
63	R:R:F187	R:R:V116	17.4152	3.93	Yes	Yes	2	8	8
64	R:R:V116	R:R:Y177	14.6645	5.05	Yes	Yes	2	8	7
65	R:R:I113	R:R:Y177	12.1708	3.63	No	Yes	2	5	7
66	R:R:F187	R:R:F205	23.6174	6.43	Yes	No	0	8	8
67	R:R:F205	R:R:L120	23.3896	7.31	No	No	0	8	6
68	R:R:L120	R:R:L208	21.7018	4.15	No	No	0	6	5
69	R:R:N296	R:R:W262	29.1713	9.04	No	No	0	9	9
70	R:R:L123	R:R:W262	13.8644	22.78	No	No	0	7	9
71	R:R:L125	R:R:V159	14.3842	2.98	No	Yes	0	7	5
72	R:R:G209	R:R:L123	13.403	1.71	Yes	No	0	7	7
73	R:R:A212	R:R:G209	28.0208	1.95	No	Yes	0	7	7
74	R:R:A212	R:R:S127	25.9417	1.71	No	No	0	7	7
75	R:R:L266	R:R:W262	14.9331	2.28	No	No	0	7	9
76	R:R:G209	R:R:L266	14.0104	1.71	Yes	No	0	7	7
77	R:R:S127	R:R:V215	24.0612	3.23	No	No	0	7	5
78	R:R:N220	R:R:R133	18.1802	6.03	Yes	Yes	3	9	9
79	R:R:I131	R:R:V215	19.3482	3.07	No	No	0	6	5
80	R:R:C134	R:R:C219	16.8078	3.64	Yes	No	0	6	7
81	R:R:L227	R:R:T223	20.5046	2.95	Yes	Yes	3	8	8
82	R:R:Y188	R:R:Y201	17.6838	7.94	Yes	Yes	2	6	6
83	R:R:I166	R:R:L204	11.0845	2.85	No	No	0	6	4
84	R:R:L204	R:R:L208	10.8626	4.15	No	No	0	4	5
85	R:R:Q180	R:R:W185	25.7782	10.95	No	Yes	2	8	8
86	R:R:Q180	R:R:T190	36.8977	9.92	No	No	0	8	7
87	R:R:I272	R:R:T190	35.4903	3.04	Yes	No	0	6	7
88	R:R:I193	R:R:I272	22.2975	1.47	Yes	Yes	0	1	6
89	R:R:D198	R:R:I193	14.4542	4.2	Yes	Yes	5	5	1
90	R:R:D195	R:R:D198	11.4408	15.97	Yes	Yes	5	1	5
91	R:R:M255	R:R:N220	16.1829	5.61	No	Yes	0	8	9
92	R:R:L217	R:R:M255	12.6672	5.65	No	No	0	5	8
93	R:R:H244	R:R:L227	15.1259	1.29	No	Yes	0	8	8
94	R:R:H244	R:R:K231	13.4264	14.41	No	No	0	8	6
95	R:R:F165	R:R:I166	11.7678	1.26	No	No	0	3	6
96	R:R:H81	R:R:Q297	31.0401	3.71	Yes	Yes	1	8	8
97	R:R:G209	R:R:L120	31.1219	1.71	Yes	No	0	7	6
98	R:R:C219	R:R:I131	16.1829	3.27	No	No	0	7	6
99	R:R:F187	R:R:Q180	12.5095	3.51	Yes	No	2	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S33	4.09	1	Yes	No	0	7	0	1
L:L:?1	R:R:H81	24.5	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N84	13.08	1	Yes	No	0	6	0	1
L:L:?1	R:R:M115	4.81	1	Yes	No	0	8	0	1
L:L:?1	R:R:S118	8.17	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:G119	3.49	1	Yes	No	0	7	0	1
L:L:?1	R:R:T184	6.02	1	Yes	No	0	9	0	1
L:L:?1	R:R:F265	4.14	1	Yes	No	0	8	0	1
L:L:?1	R:R:L290	5.65	1	Yes	No	0	7	0	1
L:L:?1	R:R:R291	6.61	1	Yes	No	0	8	0	1
L:L:?1	R:R:T294	11.03	1	Yes	No	0	9	0	1
L:L:?1	R:R:Q297	8.15	1	Yes	Yes	0	8	0	1
R:R:D77	R:R:P122	14.49	1	No	No	9	9	2	2
R:R:D77	R:R:Q297	9.14	1	No	Yes	9	8	2	1
R:R:H81	R:R:T294	4.11	1	Yes	No	8	9	1	1
R:R:H81	R:R:Q297	3.71	1	Yes	Yes	8	8	1	1
R:R:F111	R:R:N84	6.04	1	No	No	6	6	2	1
R:R:M115	R:R:N84	9.82	1	No	No	8	6	1	1
R:R:T184	R:R:Y92	7.49	0	No	Yes	9	8	1	2
R:R:F111	R:R:M115	9.95	1	No	No	6	8	2	1
R:R:G119	R:R:S118	3.71	1	No	Yes	7	7	1	1
R:R:Q297	R:R:S118	4.33	1	Yes	Yes	8	7	1	1
R:R:P122	R:R:Q297	11.05	1	No	Yes	9	8	2	1
R:R:S182	R:R:T184	6.4	0	No	No	8	9	2	1
R:R:S182	R:R:W185	4.94	0	No	Yes	8	8	2	2
R:R:L290	R:R:W185	6.83	0	No	Yes	7	8	1	2
R:R:F265	R:R:M269	7.46	0	No	No	8	7	1	2
R:R:A289	R:R:F265	4.16	0	No	No	7	8	2	1
R:R:L287	R:R:R291	10.93	0	No	No	6	8	2	1
R:R:N296	R:R:Q297	3.96	0	No	Yes	9	8	2	1
R:R:H81	R:R:I298	2.65	1	Yes	Yes	8	8	1	2
L:L:?1	R:R:A293	2.14	1	Yes	No	0	8	0	1
R:R:F32	R:R:R291	2.14	0	No	No	4	8	2	1
R:R:G80	R:R:S118	1.86	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IUM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	277
Number of Links	300
Number of Hubs	34
Number of Links mediated by Hubs	133
Number of Communities	7
Number of Nodes involved in Communities	55
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	45506
Length Of Smallest Path	3
Average Path Length	13.5455
Length of Longest Path	32
Minimum Path Strength	1.24
Average Path Strength	5.99786
Maximum Path Strength	18.79
Minimum Path Correlation	0.7
Average Path Correlation	0.925073
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	51.61
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.6462
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	S2F
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	S2F
Name	(~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E})-3,3-bis(fluoranyl)-4-phenoxy-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid
Synonyms	Tafluprost acid
Identifier
Formula	C22 H28 F2 O5
Molecular Weight	410.452
SMILES
PubChem	9978917
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	4
Total Bonds	58
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43088
Sequence	>8IUM_nogp_Chain_R S V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q K S K A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D K E W I R F D Q S N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K P I F H S T K I T S K H V K M M L S G V C L F A V F I A L L P I L G H R D Y K I Q A S R T W C F Y N T E D I K D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q Q H G R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N G N H S L E T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A V L K N L Y K L A S Q C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XJK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-		2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.85	2024-02-28	To be published
	8XJM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.85	2024-02-28	To be published
	8XJL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.77	2024-02-28	To be published
	8XJL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.77	2024-02-28	To be published
	8IQ6	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ6 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-		2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IUM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-		3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.67	2023-07-12	10.1038/s41467-023-38411-x
	8IUK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.67	2023-07-12	10.1038/s41467-023-38411-x

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