psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S33	7.32	Yes	No	0	0	7
2	L:L:?1	R:R:H81	10.74	Yes	Yes	1	0	8
3	L:L:?1	R:R:N84	3.82	Yes	Yes	1	0	6
4	L:L:?1	R:R:Y92	7.35	Yes	Yes	1	0	8
5	L:L:?1	R:R:M115	4.92	Yes	No	1	0	8
6	L:L:?1	R:R:T184	5.13	Yes	No	1	0	9
7	L:L:?1	R:R:W185	3.97	Yes	Yes	1	0	8
8	L:L:?1	R:R:L287	3.86	Yes	No	0	0	6
9	L:L:?1	R:R:L290	5.78	Yes	No	1	0	7
10	L:L:?1	R:R:T294	7.18	Yes	No	0	0	9
11	L:L:?1	R:R:Q297	6.49	Yes	Yes	1	0	8
12	R:R:F32	R:R:S29	3.96	No	No	0	4	7
13	R:R:V30	R:R:Y92	8.83	No	Yes	0	6	8
14	R:R:F32	R:R:R291	13.9	No	No	0	4	8
15	R:R:F36	R:R:W295	13.03	No	Yes	0	8	5
16	R:R:G85	R:R:M37	5.24	No	No	0	7	7
17	R:R:G40	R:R:H81	4.77	No	Yes	1	9	8
18	R:R:G40	R:R:I298	5.29	No	No	1	9	8
19	R:R:F78	R:R:I41	5.02	No	No	0	7	6
20	R:R:P301	R:R:S43	3.56	No	No	0	9	9
21	R:R:S43	R:R:W302	8.65	No	No	0	9	6
22	R:R:N44	R:R:V74	5.91	Yes	No	0	9	8
23	R:R:D77	R:R:N44	6.73	Yes	Yes	0	9	9
24	R:R:H81	R:R:N44	3.83	Yes	Yes	0	8	9
25	R:R:N44	R:R:P301	13.03	Yes	No	0	9	9
26	R:R:I50	R:R:L46	4.28	No	No	0	8	5
27	R:R:L306	R:R:L46	6.92	No	No	0	8	5
28	R:R:L315	R:R:L46	4.15	No	No	0	4	5
29	R:R:A47	R:R:P301	3.74	No	No	0	9	9
30	R:R:I48	R:R:V74	4.61	No	No	0	7	8
31	R:R:I50	R:R:V311	4.61	No	No	0	8	7
32	R:R:L51	R:R:S71	7.51	No	No	0	8	6
33	R:R:I305	R:R:L51	8.56	No	No	0	8	8
34	R:R:R59	R:R:Y55	17.49	No	No	0	5	6
35	R:R:L67	R:R:Y55	3.52	Yes	No	0	8	6
36	R:R:L68	R:R:Y55	7.03	No	No	0	6	6
37	R:R:F58	R:R:R57	9.62	No	No	0	4	4
38	R:R:F58	R:R:L67	3.65	No	Yes	0	4	8
39	R:R:K63	R:R:S65	7.65	Yes	Yes	1	6	7
40	R:R:H143	R:R:K63	9.17	Yes	Yes	1	8	6
41	R:R:I147	R:R:K63	4.36	Yes	Yes	1	5	6
42	R:R:K63	R:R:S149	6.12	Yes	No	0	6	3
43	R:R:A64	R:R:L67	4.73	No	Yes	0	7	8
44	R:R:E132	R:R:S65	8.62	Yes	Yes	1	9	7
45	R:R:H143	R:R:S65	4.18	Yes	Yes	1	8	7
46	R:R:S65	R:R:V152	4.85	Yes	No	0	7	7
47	R:R:F66	R:R:L67	3.65	Yes	Yes	0	7	8
48	R:R:A70	R:R:F66	4.16	No	Yes	0	8	7
49	R:R:F66	R:R:M129	3.73	Yes	Yes	1	7	9
50	R:R:E132	R:R:F66	4.66	Yes	Yes	1	9	7
51	R:R:F66	R:R:R133	12.83	Yes	Yes	1	7	9
52	R:R:L68	R:R:V152	4.47	No	No	0	6	7
53	R:R:L69	R:R:M129	7.07	No	Yes	0	7	9
54	R:R:E132	R:R:L69	5.3	Yes	No	0	9	7
55	R:R:D77	R:R:L73	4.07	Yes	Yes	1	9	9
56	R:R:L125	R:R:L73	4.15	No	Yes	0	7	9
57	R:R:L73	R:R:M129	7.07	Yes	Yes	1	9	9
58	R:R:D300	R:R:L73	6.79	Yes	Yes	1	9	9
59	R:R:L73	R:R:Y304	4.69	Yes	Yes	1	9	9
60	R:R:F79	R:R:I75	3.77	No	No	0	5	6
61	R:R:C121	R:R:T76	6.76	Yes	No	0	7	8
62	R:R:D77	R:R:P122	6.44	Yes	No	1	9	9
63	R:R:D77	R:R:Q297	10.44	Yes	Yes	1	9	8
64	R:R:D300	R:R:D77	3.99	Yes	Yes	1	9	9
65	R:R:F78	R:R:F79	4.29	No	No	0	7	5
66	R:R:G80	R:R:S118	3.71	No	No	0	8	7
67	R:R:H81	R:R:I298	5.3	Yes	No	1	8	8
68	R:R:F111	R:R:N84	4.83	Yes	Yes	1	6	6
69	R:R:C114	R:R:N84	4.72	No	Yes	0	4	6
70	R:R:M115	R:R:N84	8.41	No	Yes	1	8	6
71	R:R:N84	R:R:S118	7.45	Yes	No	0	6	7
72	R:R:I87	R:R:L107	5.71	No	No	0	6	5
73	R:R:F111	R:R:I87	11.3	Yes	No	0	6	6
74	R:R:F90	R:R:S94	7.93	No	No	0	5	4
75	R:R:V91	R:R:W98	9.81	No	Yes	0	7	5
76	R:R:K96	R:R:Y92	4.78	No	Yes	1	5	8
77	R:R:T184	R:R:Y92	13.73	No	Yes	1	9	8
78	R:R:K96	R:R:T184	4.5	No	No	1	5	9
79	R:R:E97	R:R:F101	4.66	No	No	0	4	4
80	R:R:D102	R:R:W98	4.47	No	Yes	0	4	5
81	R:R:F111	R:R:W98	4.01	Yes	Yes	1	6	5
82	R:R:I179	R:R:W98	8.22	No	Yes	1	5	5
83	R:R:R183	R:R:W98	6	No	Yes	1	6	5
84	R:R:C186	R:R:W98	3.92	No	Yes	1	9	5
85	R:R:D102	R:R:L107	6.79	No	No	0	4	5
86	R:R:S104	R:R:V106	4.85	No	No	0	5	3
87	R:R:C108	R:R:N105	6.3	No	No	0	9	1
88	R:R:C108	R:R:C186	7.28	No	No	0	9	9
89	R:R:F111	R:R:M115	4.98	Yes	No	1	6	8
90	R:R:C186	R:R:F111	4.19	No	Yes	1	9	6
91	R:R:G112	R:R:Y177	10.14	No	Yes	0	7	7
92	R:R:I113	R:R:L168	4.28	No	No	0	5	4
93	R:R:I113	R:R:Y177	6.04	No	Yes	0	5	7
94	R:R:V116	R:R:Y177	5.05	Yes	Yes	1	8	7
95	R:R:F187	R:R:V116	3.93	Yes	Yes	1	8	8
96	R:R:V116	R:R:Y188	10.09	Yes	Yes	1	8	6
97	R:R:C121	R:R:F117	6.98	Yes	No	0	7	7
98	R:R:I166	R:R:L120	4.28	Yes	No	0	6	6
99	R:R:F205	R:R:L120	3.65	No	No	0	8	6
100	R:R:P122	R:R:Q297	9.47	No	Yes	1	9	8
101	R:R:L123	R:R:W262	21.64	No	Yes	0	7	9
102	R:R:L125	R:R:V159	4.47	No	No	0	7	5
103	R:R:S127	R:R:V215	4.85	No	No	0	7	5
104	R:R:M129	R:R:Y304	5.99	Yes	Yes	1	9	9
105	R:R:A130	R:R:N220	4.69	No	No	0	9	9
106	R:R:E132	R:R:R133	5.82	Yes	Yes	1	9	9
107	R:R:E132	R:R:H143	4.92	Yes	Yes	1	9	8
108	R:R:M247	R:R:R133	8.69	No	Yes	1	8	9
109	R:R:Q250	R:R:R133	8.18	Yes	Yes	1	8	9
110	R:R:H143	R:R:I135	3.98	Yes	No	0	8	5
111	R:R:G136	R:R:H143	9.53	No	Yes	0	8	8
112	R:R:T223	R:R:V137	4.76	Yes	No	0	8	8
113	R:R:T138	R:R:T226	4.71	No	No	0	7	6
114	R:R:F142	R:R:K146	13.65	No	No	0	4	4
115	R:R:H143	R:R:I147	3.98	Yes	Yes	1	8	5
116	R:R:K146	R:R:T145	6.01	No	No	0	4	5
117	R:R:H151	R:R:T148	12.32	No	No	0	5	7
118	R:R:K150	R:R:M154	8.64	No	No	0	5	3
119	R:R:F162	R:R:I166	6.28	No	Yes	0	4	6
120	R:R:F165	R:R:I166	3.77	No	Yes	0	3	6
121	R:R:I166	R:R:L208	4.28	Yes	No	0	6	5
122	R:R:L169	R:R:Y201	3.52	No	Yes	0	6	6
123	R:R:P170	R:R:Y177	12.52	No	Yes	1	9	7
124	R:R:P170	R:R:Y188	6.95	No	Yes	1	9	6
125	R:R:P170	R:R:Y201	8.34	No	Yes	1	9	6
126	R:R:D195	R:R:R175	8.34	No	No	1	1	8
127	R:R:E197	R:R:R175	18.61	No	No	1	2	8
128	R:R:Y177	R:R:Y188	6.95	Yes	Yes	1	7	6
129	R:R:K178	R:R:N189	13.99	No	No	0	5	6
130	R:R:I179	R:R:R183	3.76	No	No	1	5	6
131	R:R:Q180	R:R:W185	21.9	No	Yes	1	8	8
132	R:R:Q180	R:R:T190	7.09	No	Yes	1	8	7
133	R:R:E191	R:R:Q180	3.82	No	No	1	3	8
134	R:R:A181	R:R:C283	3.61	No	No	0	4	4
135	R:R:S182	R:R:W185	3.71	Yes	Yes	0	8	8
136	R:R:L287	R:R:S182	6.01	No	Yes	0	6	8
137	R:R:F187	R:R:W185	6.01	Yes	Yes	1	8	8
138	R:R:L290	R:R:W185	9.11	No	Yes	1	7	8
139	R:R:F187	R:R:Y188	13.41	Yes	Yes	1	8	6
140	R:R:F187	R:R:F205	4.29	Yes	No	1	8	8
141	R:R:Y188	R:R:Y201	7.94	Yes	Yes	1	6	6
142	R:R:L202	R:R:Y188	4.69	No	Yes	0	6	6
143	R:R:F205	R:R:Y188	6.19	No	Yes	1	8	6
144	R:R:D198	R:R:N189	13.46	No	No	0	5	6
145	R:R:E191	R:R:T190	9.88	No	Yes	1	3	7
146	R:R:L202	R:R:T190	5.9	No	Yes	0	6	7
147	R:R:I272	R:R:T190	4.56	No	Yes	0	6	7
148	R:R:D198	R:R:I193	11.2	No	Yes	0	5	1
149	R:R:I193	R:R:R199	5.01	Yes	No	0	1	3
150	R:R:G276	R:R:I193	3.53	No	Yes	0	1	1
151	R:R:D195	R:R:W196	8.93	No	No	1	1	1
152	R:R:D195	R:R:E197	7.8	No	No	1	1	2
153	R:R:E197	R:R:W196	17.45	No	No	1	2	1
154	R:R:F200	R:R:Y201	4.13	No	Yes	0	5	6
155	R:R:L204	R:R:L208	5.54	No	No	0	4	5
156	R:R:L210	R:R:L266	6.92	No	No	0	5	7
157	R:R:L213	R:R:S258	4.5	No	No	0	8	9
158	R:R:L217	R:R:M255	4.24	No	No	0	5	8
159	R:R:C259	R:R:L217	4.76	No	No	0	5	5
160	R:R:L251	R:R:N220	4.12	No	No	0	8	9
161	R:R:M255	R:R:N220	5.61	No	No	0	8	9
162	R:R:H244	R:R:L227	6.43	No	No	0	8	8
163	R:R:L228	R:R:V248	4.47	No	No	0	5	7
164	R:R:H244	R:R:V230	4.15	No	No	0	8	7
165	R:R:F232	R:R:K231	6.2	No	No	0	5	6
166	R:R:H244	R:R:K231	11.79	No	No	0	8	6
167	R:R:H243	R:R:S242	6.97	No	No	0	5	6
168	R:R:E246	R:R:R308	5.82	No	No	0	7	9
169	R:R:E246	R:R:K309	6.75	No	No	0	7	7
170	R:R:M247	R:R:Q250	6.8	No	Yes	1	8	8
171	R:R:L251	R:R:M247	4.24	No	No	0	8	8
172	R:R:I254	R:R:Q250	5.49	No	Yes	0	8	8
173	R:R:Q250	R:R:R308	17.52	Yes	No	0	8	9
174	R:R:I254	R:R:Y304	14.51	No	Yes	0	8	9
175	R:R:L299	R:R:V257	4.47	No	No	0	7	7
176	R:R:V257	R:R:V303	4.81	No	No	0	7	8
177	R:R:C261	R:R:N296	6.3	No	Yes	0	8	9
178	R:R:L266	R:R:W262	7.97	No	Yes	0	7	9
179	R:R:A293	R:R:W262	7.78	No	Yes	0	8	9
180	R:R:N296	R:R:W262	12.43	Yes	Yes	1	9	9
181	R:R:Q297	R:R:W262	6.57	Yes	Yes	1	8	9
182	R:R:F265	R:R:M269	7.46	No	No	0	8	7
183	R:R:A289	R:R:F265	4.16	No	No	0	7	8
184	R:R:F265	R:R:L290	7.31	No	No	0	8	7
185	R:R:E281	R:R:T268	9.88	No	No	0	1	5
186	R:R:N271	R:R:N275	8.17	No	No	2	4	1
187	R:R:N271	R:R:S279	4.47	No	No	2	4	1
188	R:R:E281	R:R:I272	15.03	No	No	0	1	6
189	R:R:N275	R:R:S279	4.47	No	No	2	1	1
190	R:R:E281	R:R:T286	12.7	No	No	0	1	7
191	R:R:E284	R:R:T282	7.06	No	No	0	1	4
192	R:R:T282	R:R:T285	4.71	No	No	0	4	2
193	R:R:L287	R:R:R291	6.07	No	No	0	6	8
194	R:R:F288	R:R:M292	7.46	No	No	0	4	6
195	R:R:T294	R:R:W295	4.85	No	Yes	0	9	5
196	R:R:I298	R:R:W295	8.22	No	Yes	0	8	5
197	R:R:N296	R:R:Q297	9.24	Yes	Yes	1	9	8
198	R:R:D300	R:R:N296	6.73	Yes	Yes	1	9	9
199	R:R:D300	R:R:Y304	5.75	Yes	Yes	1	9	9
200	R:R:L306	R:R:W302	18.22	No	No	0	8	6
201	R:R:L307	R:R:W302	6.83	No	No	0	6	6
202	R:R:K317	R:R:S320	4.59	No	No	0	4	5
203	R:R:K317	R:R:Q321	10.85	No	No	0	4	3
204	R:R:G126	R:R:M129	3.49	No	Yes	0	8	9
205	R:R:C283	R:R:S182	3.44	No	Yes	0	4	8
206	R:R:A88	R:R:S33	3.42	No	No	0	8	7
207	R:R:A212	R:R:S127	3.42	No	No	0	7	7
208	R:R:G273	R:R:L202	3.42	No	No	0	4	6
209	R:R:G273	R:R:L203	3.42	No	No	0	4	4
210	R:R:A270	R:R:S206	3.42	No	No	0	5	7
211	R:R:G209	R:R:L266	3.42	No	No	0	7	7
212	R:R:L299	R:R:W295	3.42	No	Yes	0	7	5
213	R:R:A167	R:R:V116	3.39	No	Yes	0	8	8
214	R:R:C134	R:R:T138	3.38	Yes	No	0	6	7
215	R:R:C134	R:R:T223	3.38	Yes	Yes	0	6	8
216	R:R:M292	R:R:P264	3.35	No	No	0	6	9
217	R:R:C114	R:R:I83	3.27	No	No	0	4	5
218	R:R:C219	R:R:I131	3.27	No	No	0	7	6
219	R:R:C134	R:R:I222	3.27	Yes	No	0	6	4
220	R:R:A47	R:R:I305	3.25	No	No	0	9	8
221	R:R:F101	R:R:R100	3.21	No	No	0	4	1
222	R:R:G173	R:R:H174	3.18	No	No	0	7	4
223	R:R:C121	R:R:L125	3.17	Yes	No	0	7	7
224	R:R:C259	R:R:L213	3.17	No	No	0	5	8
225	R:R:I272	R:R:S279	3.1	No	No	0	6	1
226	R:R:R175	R:R:Y201	3.09	No	Yes	1	8	6
227	R:R:I131	R:R:V215	3.07	No	No	0	6	5
228	R:R:K61	R:R:S62	3.06	No	No	0	5	7
229	R:R:M37	R:R:V89	3.04	No	No	0	7	6
230	R:R:I141	R:R:T145	3.04	No	No	0	5	5
231	R:R:L28	R:R:S182	3	No	Yes	0	4	8
232	R:R:K139	R:R:T138	3	No	No	0	5	7
233	R:R:N105	R:R:S109	2.98	No	No	0	1	4
234	R:R:L124	R:R:V159	2.98	No	No	0	5	5
235	R:R:L227	R:R:V137	2.98	No	No	0	8	8
236	R:R:L168	R:R:V164	2.98	No	No	0	4	4
237	R:R:L227	R:R:V248	2.98	No	No	0	8	7
238	R:R:L251	R:R:T223	2.95	No	Yes	0	8	8
239	R:R:I48	R:R:I75	2.94	No	No	0	7	6
240	R:R:D176	R:R:S109	2.94	No	No	0	3	4
241	R:R:I113	R:R:I171	2.94	No	No	0	5	4
242	R:R:I48	R:R:M52	2.92	No	No	0	7	4
243	R:R:K309	R:R:K313	2.87	No	No	0	7	4
244	R:R:I41	R:R:L82	2.85	No	No	0	6	5
245	R:R:I274	R:R:L203	2.85	No	No	0	3	4
246	R:R:K153	R:R:L68	2.82	No	No	0	5	6
247	R:R:G119	R:R:W262	2.81	No	Yes	0	7	9
248	R:R:L156	R:R:L69	2.77	No	No	0	7	7
249	R:R:D95	R:R:K96	2.77	No	No	0	4	5
250	R:R:A163	R:R:F117	2.77	No	No	0	7	7
251	R:R:F101	R:R:S94	2.64	No	No	0	4	4
252	R:R:H151	R:R:K150	2.62	No	No	0	5	5
253	R:R:F90	R:R:L107	2.44	No	No	0	5	5
254	R:R:F207	R:R:L208	2.44	No	No	0	4	5
255	R:R:F207	R:R:L211	2.44	No	No	0	4	4
256	L:L:?1	R:R:G85	2.38	Yes	No	0	0	7
257	R:R:Q56	R:R:R59	2.34	No	No	0	4	5
258	R:R:F288	R:R:R27	2.14	No	No	0	4	2
259	R:R:R27	R:R:R291	2.13	No	No	0	2	8
260	R:R:G72	R:R:S71	1.86	No	No	0	8	6
261	R:R:C121	R:R:C160	1.82	Yes	No	0	7	6
262	R:R:C134	R:R:C219	1.82	Yes	No	0	6	7
263	R:R:G224	R:R:T223	1.82	No	Yes	0	7	8
264	R:R:P264	R:R:S263	1.78	No	No	0	9	5
265	R:R:G273	R:R:I193	1.76	No	Yes	0	4	1
266	R:R:A130	R:R:S216	1.71	No	No	0	9	8
267	R:R:G214	R:R:L213	1.71	No	No	0	3	8
268	R:R:A253	R:R:V303	1.7	No	No	0	5	8
269	R:R:K139	R:R:P140	1.67	No	No	0	5	8
270	R:R:C114	R:R:I110	1.64	No	No	0	4	5
271	R:R:S43	R:R:V39	1.62	No	No	0	9	6
272	R:R:V30	R:R:V34	1.6	No	No	0	6	4
273	R:R:V34	R:R:V89	1.6	No	No	0	4	6
274	R:R:V128	R:R:V159	1.6	No	No	0	7	5
275	R:R:T38	R:R:V34	1.59	No	No	0	5	4
276	R:R:I35	R:R:V39	1.54	No	No	0	4	6
277	R:R:I110	R:R:V106	1.54	No	No	0	5	3
278	R:R:M269	R:R:S206	1.53	No	No	0	7	7
279	R:R:M155	R:R:V128	1.52	No	No	0	5	7
280	R:R:L42	R:R:T38	1.47	No	No	0	4	5
281	R:R:G173	R:R:Y201	1.45	No	Yes	0	7	6
282	R:R:I222	R:R:L218	1.43	No	No	0	4	3
283	R:R:A54	R:R:F58	1.39	No	No	0	7	4
284	R:R:L312	R:R:L315	1.38	No	No	0	7	4
285	R:R:I99	R:R:Q103	1.37	No	No	0	1	4
286	R:R:H151	R:R:I147	1.33	No	Yes	0	5	5
287	R:R:F31	R:R:S29	1.32	No	No	0	4	7
288	R:R:F78	R:R:S45	1.32	No	No	0	7	5
289	R:R:F142	R:R:I135	1.26	No	No	0	4	5
290	R:R:F142	R:R:I147	1.26	No	Yes	0	4	5
291	R:R:N26	R:R:R27	1.21	No	No	0	3	2
292	R:R:Q60	R:R:R59	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.745	12	1	0
2	R:R:N44	7.375	4	0	9
3	R:R:K63	6.825	4	1	6
4	R:R:S65	6.325	4	1	7
5	R:R:F66	5.806	5	1	7
6	R:R:L67	3.8875	4	0	8
7	R:R:L73	5.354	5	1	9
8	R:R:D77	6.334	5	1	9
9	R:R:H81	6.16	4	1	8
10	R:R:N84	5.846	5	1	6
11	R:R:Y92	8.6725	4	1	8
12	R:R:W98	6.07167	6	1	5
13	R:R:F111	5.862	5	1	6
14	R:R:V116	5.615	4	1	8
15	R:R:C121	4.6825	4	0	7
16	R:R:M129	5.47	5	1	9
17	R:R:E132	5.864	5	1	9
18	R:R:R133	8.88	4	1	9
19	R:R:C134	2.9625	4	0	6
20	R:R:H143	5.96	6	1	8
21	R:R:I147	2.7325	4	1	5
22	R:R:I166	4.6525	4	0	6
23	R:R:Y177	8.14	5	1	7
24	R:R:S182	4.04	4	0	8
25	R:R:W185	8.94	5	1	8
26	R:R:F187	6.91	4	1	8
27	R:R:Y188	8.03143	7	1	6
28	R:R:T190	6.8575	4	1	7
29	R:R:I193	5.375	4	0	1
30	R:R:Y201	4.745	6	1	6
31	R:R:T223	3.2275	4	0	8
32	R:R:Q250	9.4975	4	1	8
33	R:R:W262	9.86667	6	1	9
34	R:R:W295	7.38	4	0	5
35	R:R:N296	8.675	4	1	9
36	R:R:Q297	8.442	5	1	8
37	R:R:D300	5.815	4	1	9
38	R:R:Y304	7.735	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L287	15.1384	3.86	Yes	No	0	0	6
2	R:R:L287	R:R:R291	12.4285	6.07	No	No	0	6	8
3	L:L:?1	R:R:H81	11.9162	10.74	Yes	Yes	1	0	8
4	R:R:H81	R:R:N44	15.7183	3.83	Yes	Yes	0	8	9
5	R:R:N44	R:R:P301	16.3633	13.03	Yes	No	0	9	9
6	R:R:P301	R:R:S43	10.6678	3.56	No	No	0	9	9
7	L:L:?1	R:R:Q297	100	6.49	Yes	Yes	1	0	8
8	R:R:D77	R:R:Q297	80.9763	10.44	Yes	Yes	1	9	8
9	R:R:D77	R:R:L73	77.3354	4.07	Yes	Yes	1	9	9
10	R:R:L73	R:R:M129	55.3027	7.07	Yes	Yes	1	9	9
11	R:R:F66	R:R:M129	40.9342	3.73	Yes	Yes	1	7	9
12	R:R:E132	R:R:F66	14.9121	4.66	Yes	Yes	1	9	7
13	R:R:L69	R:R:M129	15.5987	7.07	No	Yes	0	7	9
14	R:R:E132	R:R:L69	14.6572	5.3	Yes	No	0	9	7
15	R:R:E132	R:R:H143	24.8232	4.92	Yes	Yes	1	9	8
16	R:R:H143	R:R:I147	12.7432	3.98	Yes	Yes	1	8	5
17	R:R:F66	R:R:R133	19.8975	12.83	Yes	Yes	1	7	9
18	R:R:D300	R:R:D77	21.2395	3.99	Yes	Yes	1	9	9
19	R:R:N296	R:R:Q297	18.0537	9.24	Yes	Yes	1	9	8
20	R:R:D300	R:R:N296	21.4319	6.73	Yes	Yes	1	9	9
21	R:R:L73	R:R:Y304	21.7206	4.69	Yes	Yes	1	9	9
22	R:R:D300	R:R:Y304	39.9407	5.75	Yes	Yes	1	9	9
23	L:L:?1	R:R:N84	25.8296	3.82	Yes	Yes	1	0	6
24	R:R:F111	R:R:N84	18.1421	4.83	Yes	Yes	1	6	6
25	L:L:?1	R:R:M115	18.7975	4.92	Yes	No	1	0	8
26	R:R:F111	R:R:M115	17.8274	4.98	Yes	No	1	6	8
27	R:R:F111	R:R:I87	14.3712	11.3	Yes	No	0	6	6
28	R:R:I87	R:R:L107	12.3245	5.71	No	No	0	6	5
29	R:R:F90	R:R:L107	10.4026	2.44	No	No	0	5	5
30	R:R:C186	R:R:F111	10.1633	4.19	No	Yes	1	9	6
31	L:L:?1	R:R:W185	64.1527	3.97	Yes	Yes	1	0	8
32	R:R:F187	R:R:W185	44.3384	6.01	Yes	Yes	1	8	8
33	R:R:F187	R:R:Y188	27.2314	13.41	Yes	Yes	1	8	6
34	R:R:M247	R:R:R133	21.4709	8.69	No	Yes	1	8	9
35	R:R:L251	R:R:M247	69.6323	4.24	No	No	0	8	8
36	R:R:L251	R:R:T223	48.411	2.95	No	Yes	0	8	8
37	R:R:C134	R:R:T223	26.8673	3.38	Yes	Yes	0	6	8
38	R:R:C134	R:R:C219	11.2842	1.82	Yes	No	0	6	7
39	R:R:I254	R:R:Y304	58.6628	14.51	No	Yes	0	8	9
40	R:R:I254	R:R:Q250	57.3078	5.49	No	Yes	0	8	8
41	R:R:M247	R:R:Q250	50.1846	6.8	No	Yes	1	8	8
42	R:R:L251	R:R:N220	20.22	4.12	No	No	0	8	9
43	R:R:T223	R:R:V137	17.9913	4.76	Yes	No	0	8	8
44	R:R:Y188	R:R:Y201	10.7381	7.94	Yes	Yes	1	6	6
45	R:R:Q180	R:R:W185	19.367	21.9	No	Yes	1	8	8
46	R:R:Q180	R:R:T190	17.4399	7.09	No	Yes	1	8	7
47	R:R:L202	R:R:T190	10.6262	5.9	No	Yes	0	6	7
48	R:R:G273	R:R:L202	18.4178	3.42	No	No	0	4	6
49	R:R:G273	R:R:I193	12.3245	1.76	No	Yes	0	4	1
50	R:R:L202	R:R:Y188	11.2218	4.69	No	Yes	0	6	6
51	R:R:M255	R:R:N220	13.526	5.61	No	No	0	8	9
52	R:R:L217	R:R:M255	11.2842	4.24	No	No	0	5	8
53	R:R:L227	R:R:V137	15.7573	2.98	No	No	0	8	8
54	R:R:D77	R:R:N44	18.6284	6.73	Yes	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S33	7.32	1	Yes	No	0	7	0	1
L:L:?1	R:R:H81	10.74	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N84	3.82	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y92	7.35	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M115	4.92	1	Yes	No	0	8	0	1
L:L:?1	R:R:T184	5.13	1	Yes	No	0	9	0	1
L:L:?1	R:R:W185	3.97	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L287	3.86	1	Yes	No	0	6	0	1
L:L:?1	R:R:L290	5.78	1	Yes	No	0	7	0	1
L:L:?1	R:R:T294	7.18	1	Yes	No	0	9	0	1
L:L:?1	R:R:Q297	6.49	1	Yes	Yes	0	8	0	1
R:R:V30	R:R:Y92	8.83	0	No	Yes	6	8	2	1
R:R:G85	R:R:M37	5.24	0	No	No	7	7	1	2
R:R:G40	R:R:H81	4.77	1	No	Yes	9	8	2	1
R:R:G40	R:R:I298	5.29	1	No	No	9	8	2	2
R:R:D77	R:R:N44	6.73	1	Yes	Yes	9	9	2	2
R:R:H81	R:R:N44	3.83	1	Yes	Yes	8	9	1	2
R:R:D77	R:R:P122	6.44	1	Yes	No	9	9	2	2
R:R:D77	R:R:Q297	10.44	1	Yes	Yes	9	8	2	1
R:R:H81	R:R:I298	5.3	1	Yes	No	8	8	1	2
R:R:F111	R:R:N84	4.83	1	Yes	Yes	6	6	2	1
R:R:C114	R:R:N84	4.72	0	No	Yes	4	6	2	1
R:R:M115	R:R:N84	8.41	1	No	Yes	8	6	1	1
R:R:N84	R:R:S118	7.45	1	Yes	No	6	7	1	2
R:R:K96	R:R:Y92	4.78	1	No	Yes	5	8	2	1
R:R:T184	R:R:Y92	13.73	1	No	Yes	9	8	1	1
R:R:K96	R:R:T184	4.5	1	No	No	5	9	2	1
R:R:F111	R:R:M115	4.98	1	Yes	No	6	8	2	1
R:R:P122	R:R:Q297	9.47	1	No	Yes	9	8	2	1
R:R:Q180	R:R:W185	21.9	1	No	Yes	8	8	2	1
R:R:S182	R:R:W185	3.71	0	Yes	Yes	8	8	2	1
R:R:L287	R:R:S182	6.01	0	No	Yes	6	8	1	2
R:R:F187	R:R:W185	6.01	1	Yes	Yes	8	8	2	1
R:R:L290	R:R:W185	9.11	1	No	Yes	7	8	1	1
R:R:N296	R:R:W262	12.43	1	Yes	Yes	9	9	2	2
R:R:Q297	R:R:W262	6.57	1	Yes	Yes	8	9	1	2
R:R:F265	R:R:L290	7.31	0	No	No	8	7	2	1
R:R:L287	R:R:R291	6.07	0	No	No	6	8	1	2
R:R:T294	R:R:W295	4.85	0	No	Yes	9	5	1	2
R:R:I298	R:R:W295	8.22	1	No	Yes	8	5	2	2
R:R:N296	R:R:Q297	9.24	1	Yes	Yes	9	8	2	1
R:R:A88	R:R:S33	3.42	0	No	No	8	7	2	1
L:L:?1	R:R:G85	2.38	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XJL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	260
Number of Links	292
Number of Hubs	38
Number of Links mediated by Hubs	138
Number of Communities	2
Number of Nodes involved in Communities	51
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	69950
Length Of Smallest Path	3
Average Path Length	12.9429
Length of Longest Path	25
Minimum Path Strength	1.26
Average Path Strength	6.12193
Maximum Path Strength	18.03
Minimum Path Correlation	0.7
Average Path Correlation	0.916713
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	45.641
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.012
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • defense response • response to stress • inflammatory response • response to ketone • response to prostaglandin • response to lipid • cellular response to prostaglandin D stimulus • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to prostaglandin D • response to chemical • cellular response to lipid • cellular response to ketone • cellular response to hormone stimulus • multi-multicellular organism process • multicellular organismal process • reproductive process • parturition • multi-organism reproductive process • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to estradiol • cellular anatomical structure • extracellular region • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • cellular response to prostaglandin E stimulus • response to prostaglandin E • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UGU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	UGU
Name	Dinoprost
Synonyms	Dinoprost; Prostaglandin F2a; PGF2alpha
Identifier
Formula	C20 H34 O5
Molecular Weight	354.481
SMILES
PubChem	5280363
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	5
Total Bonds	59
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43088
Sequence	>8XJL_nogp_Chain_R N R L S V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q K S K A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D K E W I R F D Q S N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K P I F H S T K I T S K H V K M M L S G V C L F A V F I A L L P I L G H R D Y K I Q A S R T W C F Y N T E D I K D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N G N H S L E T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A V L K N L Y K L A S Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IUK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.67	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.67	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.78	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.78	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IUM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-		3.14	2023-07-12	doi.org/10.1038/s41467-023-38411-x
	8IQ4	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8IQ4 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-		2.7	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8IQ6	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.4	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8IQ6 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		3.4	2024-01-31	doi.org/10.1038/s41467-023-43922-8
	8XJK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-		2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.77	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.77	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.85	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.85	2024-02-28	doi.org/10.1016/j.celrep.2024.113893

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