psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S33	8.76	Yes	No	0	0	7
2	L:L:?1	R:R:H81	20	Yes	No	1	0	8
3	L:L:?1	R:R:N84	7.12	Yes	No	1	0	6
4	L:L:?1	R:R:G85	4.43	Yes	No	0	0	7
5	L:L:?1	R:R:Y92	6.84	Yes	Yes	1	0	8
6	L:L:?1	R:R:F111	3.16	Yes	Yes	1	0	6
7	L:L:?1	R:R:M115	11.91	Yes	Yes	1	0	8
8	L:L:?1	R:R:S118	3.89	Yes	No	0	0	7
9	L:L:?1	R:R:G119	3.33	Yes	No	0	0	7
10	L:L:?1	R:R:T184	8.6	Yes	Yes	1	0	9
11	L:L:?1	R:R:W185	5.17	Yes	Yes	1	0	8
12	L:L:?1	R:R:F187	5.53	Yes	Yes	1	0	8
13	L:L:?1	R:R:W262	3.69	Yes	Yes	1	0	9
14	L:L:?1	R:R:F265	4.74	Yes	Yes	1	0	8
15	L:L:?1	R:R:L287	4.49	Yes	No	1	0	6
16	L:L:?1	R:R:L290	7.18	Yes	Yes	1	0	7
17	L:L:?1	R:R:R291	3.15	Yes	Yes	1	0	8
18	L:L:?1	R:R:T294	5.73	Yes	No	0	0	9
19	L:L:?1	R:R:Q297	3.45	Yes	Yes	1	0	8
20	R:R:S29	R:R:Y92	3.82	No	Yes	0	7	8
21	R:R:F31	R:R:V30	5.24	No	No	0	4	6
22	R:R:V30	R:R:Y92	8.83	No	Yes	0	6	8
23	R:R:F32	R:R:R291	18.17	No	Yes	0	4	8
24	R:R:A88	R:R:S33	3.42	No	No	0	8	7
25	R:R:F36	R:R:R291	4.28	No	Yes	0	8	8
26	R:R:F36	R:R:T294	5.19	No	No	0	8	9
27	R:R:F36	R:R:W295	11.02	No	No	0	8	5
28	R:R:I41	R:R:M37	4.37	Yes	No	0	6	7
29	R:R:I298	R:R:V39	4.61	No	No	0	8	6
30	R:R:G40	R:R:S43	3.71	No	No	0	9	9
31	R:R:G40	R:R:I298	5.29	No	No	0	9	8
32	R:R:F78	R:R:I41	3.77	No	Yes	0	7	6
33	R:R:S43	R:R:W302	6.18	No	Yes	0	9	6
34	R:R:N44	R:R:V74	5.91	No	Yes	0	9	8
35	R:R:F78	R:R:N44	6.04	No	No	0	7	9
36	R:R:N44	R:R:P301	8.15	No	No	0	9	9
37	R:R:A47	R:R:V74	5.09	No	Yes	0	9	8
38	R:R:A47	R:R:L306	3.15	No	No	0	9	8
39	R:R:I48	R:R:M52	4.37	No	No	0	7	4
40	R:R:I48	R:R:V74	4.61	No	Yes	0	7	8
41	R:R:I50	R:R:V311	9.22	No	No	0	8	7
42	R:R:I50	R:R:L315	8.56	No	No	0	8	4
43	R:R:A70	R:R:L51	4.73	No	Yes	0	8	8
44	R:R:I305	R:R:L51	8.56	No	Yes	0	8	8
45	R:R:A54	R:R:L67	3.15	No	Yes	0	7	8
46	R:R:R59	R:R:Y55	4.12	No	No	0	5	6
47	R:R:L68	R:R:Y55	10.55	No	No	0	6	6
48	R:R:F58	R:R:L67	3.65	No	Yes	0	4	8
49	R:R:H143	R:R:K63	6.55	Yes	No	0	8	6
50	R:R:A64	R:R:L67	4.73	No	Yes	0	7	8
51	R:R:E132	R:R:S65	10.06	Yes	No	0	9	7
52	R:R:S65	R:R:V152	9.7	No	No	0	7	7
53	R:R:F66	R:R:M129	4.98	Yes	No	0	7	9
54	R:R:E132	R:R:F66	3.5	Yes	Yes	0	9	7
55	R:R:F66	R:R:R133	6.41	Yes	Yes	0	7	9
56	R:R:L69	R:R:M129	7.07	Yes	No	0	7	9
57	R:R:E132	R:R:L69	5.3	Yes	Yes	0	9	7
58	R:R:L69	R:R:V152	4.47	Yes	No	0	7	7
59	R:R:D77	R:R:L73	6.79	No	No	0	9	9
60	R:R:L125	R:R:L73	8.3	No	No	0	7	9
61	R:R:D77	R:R:T76	4.34	No	No	0	9	8
62	R:R:F117	R:R:T76	3.89	No	No	4	7	8
63	R:R:C121	R:R:T76	8.45	No	No	4	7	8
64	R:R:D77	R:R:P122	12.88	No	No	0	9	9
65	R:R:F78	R:R:F79	5.36	No	No	0	7	5
66	R:R:G80	R:R:S118	3.71	No	No	0	8	7
67	R:R:H81	R:R:Q297	4.95	No	Yes	1	8	8
68	R:R:C114	R:R:I83	3.27	No	No	0	4	5
69	R:R:F111	R:R:N84	9.67	Yes	No	1	6	6
70	R:R:C114	R:R:N84	4.72	No	No	0	4	6
71	R:R:F111	R:R:I87	18.84	Yes	No	0	6	6
72	R:R:F101	R:R:F90	8.57	Yes	No	2	4	5
73	R:R:V91	R:R:W98	11.03	No	Yes	2	7	5
74	R:R:F101	R:R:V91	7.87	Yes	No	2	4	7
75	R:R:T184	R:R:Y92	14.98	Yes	Yes	1	9	8
76	R:R:R100	R:R:S94	5.27	No	No	0	1	4
77	R:R:F101	R:R:S94	9.25	Yes	No	0	4	4
78	R:R:K96	R:R:T184	4.5	No	Yes	0	5	9
79	R:R:E97	R:R:R100	8.14	No	No	0	4	1
80	R:R:F101	R:R:W98	11.02	Yes	Yes	2	4	5
81	R:R:D102	R:R:W98	7.82	No	Yes	0	4	5
82	R:R:I179	R:R:W98	12.92	No	Yes	0	5	5
83	R:R:C108	R:R:D102	4.67	No	No	0	9	4
84	R:R:S104	R:R:V106	3.23	No	No	0	5	3
85	R:R:D176	R:R:N105	4.04	No	No	0	3	1
86	R:R:C108	R:R:C186	7.28	No	No	0	9	9
87	R:R:F111	R:R:M115	4.98	Yes	Yes	1	6	8
88	R:R:G112	R:R:Y177	8.69	No	Yes	0	7	7
89	R:R:A167	R:R:I113	4.87	No	No	0	8	5
90	R:R:I113	R:R:L168	11.42	No	No	0	5	4
91	R:R:I113	R:R:Y177	4.84	No	Yes	0	5	7
92	R:R:F187	R:R:M115	4.98	Yes	Yes	1	8	8
93	R:R:L290	R:R:M115	4.24	Yes	Yes	1	7	8
94	R:R:A167	R:R:V116	3.39	No	Yes	0	8	8
95	R:R:V116	R:R:Y177	5.05	Yes	Yes	1	8	7
96	R:R:F187	R:R:V116	5.24	Yes	Yes	1	8	8
97	R:R:V116	R:R:Y188	11.36	Yes	Yes	1	8	6
98	R:R:C121	R:R:F117	4.19	No	No	4	7	7
99	R:R:L120	R:R:L124	5.54	No	No	0	6	5
100	R:R:F205	R:R:L120	4.87	No	No	0	8	6
101	R:R:L120	R:R:L208	5.54	No	Yes	0	6	5
102	R:R:C121	R:R:P122	3.77	No	No	0	7	9
103	R:R:P122	R:R:Q297	9.47	No	Yes	0	9	8
104	R:R:L123	R:R:W262	21.64	No	Yes	0	7	9
105	R:R:A212	R:R:L124	3.15	No	No	0	7	5
106	R:R:L125	R:R:L156	4.15	No	No	0	7	7
107	R:R:S127	R:R:V215	3.23	No	No	0	7	5
108	R:R:M155	R:R:V128	4.56	No	No	0	5	7
109	R:R:M129	R:R:Y304	3.59	No	Yes	0	9	9
110	R:R:A130	R:R:S216	3.42	No	No	6	9	8
111	R:R:A130	R:R:N220	4.69	No	Yes	6	9	9
112	R:R:C219	R:R:I131	3.27	No	No	0	7	6
113	R:R:E132	R:R:H143	7.39	Yes	Yes	0	9	8
114	R:R:Q250	R:R:R133	4.67	No	Yes	3	8	9
115	R:R:L251	R:R:R133	4.86	No	Yes	0	8	9
116	R:R:I254	R:R:R133	3.76	No	Yes	3	8	9
117	R:R:C134	R:R:C219	3.64	No	No	0	6	7
118	R:R:C134	R:R:I222	3.27	No	No	0	6	4
119	R:R:C134	R:R:T223	3.38	No	Yes	0	6	8
120	R:R:G136	R:R:H143	4.77	No	Yes	0	8	8
121	R:R:T223	R:R:V137	4.76	Yes	No	0	8	8
122	R:R:K139	R:R:T138	4.5	No	No	0	5	7
123	R:R:F142	R:R:K139	9.93	Yes	No	0	4	5
124	R:R:F142	R:R:K146	11.17	Yes	No	0	4	4
125	R:R:F142	R:R:I147	5.02	Yes	No	0	4	5
126	R:R:H143	R:R:I147	5.3	Yes	No	0	8	5
127	R:R:K146	R:R:T145	4.5	No	No	0	4	5
128	R:R:K153	R:R:S149	4.59	No	No	0	5	3
129	R:R:C160	R:R:L156	3.17	No	No	0	6	7
130	R:R:F162	R:R:I166	11.3	No	No	5	4	6
131	R:R:F162	R:R:L208	4.87	No	Yes	5	4	5
132	R:R:F165	R:R:I166	3.77	No	No	0	3	6
133	R:R:F165	R:R:L169	4.87	No	No	0	3	6
134	R:R:I166	R:R:L208	4.28	No	Yes	5	6	5
135	R:R:L169	R:R:P170	3.28	No	No	0	6	9
136	R:R:P170	R:R:Y177	9.74	No	Yes	1	9	7
137	R:R:P170	R:R:Y188	5.56	No	Yes	1	9	6
138	R:R:I171	R:R:Y177	3.63	No	Yes	0	4	7
139	R:R:E197	R:R:R175	9.3	No	No	0	2	8
140	R:R:D198	R:R:R175	15.48	No	No	0	5	8
141	R:R:D176	R:R:K178	4.15	No	No	0	3	5
142	R:R:Y177	R:R:Y188	8.94	Yes	Yes	1	7	6
143	R:R:K178	R:R:N189	5.6	No	No	0	5	6
144	R:R:I179	R:R:R183	7.52	No	No	0	5	6
145	R:R:C186	R:R:I179	3.27	No	No	0	9	5
146	R:R:Q180	R:R:W185	13.14	No	Yes	1	8	8
147	R:R:F187	R:R:Q180	3.51	Yes	No	1	8	8
148	R:R:Q180	R:R:T190	9.92	No	No	0	8	7
149	R:R:A181	R:R:C283	3.61	No	No	0	4	4
150	R:R:S182	R:R:T184	6.4	No	Yes	1	8	9
151	R:R:S182	R:R:W185	4.94	No	Yes	1	8	8
152	R:R:T184	R:R:W185	4.85	Yes	Yes	1	9	8
153	R:R:F187	R:R:W185	7.02	Yes	Yes	1	8	8
154	R:R:L290	R:R:W185	5.69	Yes	Yes	1	7	8
155	R:R:F187	R:R:Y188	10.32	Yes	Yes	1	8	6
156	R:R:F187	R:R:F205	3.22	Yes	No	1	8	8
157	R:R:L202	R:R:Y188	4.69	No	Yes	0	6	6
158	R:R:F205	R:R:Y188	6.19	No	Yes	1	8	6
159	R:R:D198	R:R:N189	13.46	No	No	0	5	6
160	R:R:I193	R:R:R199	6.26	No	No	0	1	3
161	R:R:D195	R:R:W196	5.58	No	No	0	1	1
162	R:R:D195	R:R:E197	7.8	No	No	0	1	2
163	R:R:F200	R:R:W196	8.02	No	No	0	5	1
164	R:R:G276	R:R:R199	4.5	No	No	0	1	3
165	R:R:F200	R:R:Y201	4.13	No	No	0	5	6
166	R:R:G273	R:R:L202	3.42	No	No	0	4	6
167	R:R:L204	R:R:L208	5.54	No	Yes	0	4	5
168	R:R:A270	R:R:S206	3.42	No	No	0	5	7
169	R:R:G209	R:R:L266	3.42	No	No	0	7	7
170	R:R:L210	R:R:L266	6.92	No	No	0	5	7
171	R:R:C259	R:R:L213	4.76	No	No	0	5	8
172	R:R:N220	R:R:S216	5.96	Yes	No	6	9	8
173	R:R:L217	R:R:M255	4.24	No	No	0	5	8
174	R:R:C259	R:R:L217	4.76	No	No	0	5	5
175	R:R:I222	R:R:L218	5.71	No	No	0	4	3
176	R:R:L251	R:R:N220	4.12	No	Yes	0	8	9
177	R:R:M255	R:R:N220	5.61	No	Yes	0	8	9
178	R:R:A221	R:R:M255	3.22	No	No	0	4	8
179	R:R:I225	R:R:R229	7.52	No	No	0	3	4
180	R:R:H244	R:R:L227	3.86	No	Yes	0	8	8
181	R:R:F232	R:R:L228	4.87	No	No	0	5	5
182	R:R:L228	R:R:V248	4.47	No	No	0	5	7
183	R:R:K231	R:R:R241	11.14	No	No	0	6	4
184	R:R:H244	R:R:K231	19.65	No	No	0	8	6
185	R:R:H243	R:R:S242	4.18	No	No	0	5	6
186	R:R:I249	R:R:L245	5.71	No	No	0	6	4
187	R:R:E246	R:R:R308	4.65	No	No	0	7	9
188	R:R:E246	R:R:K309	14.85	No	No	0	7	7
189	R:R:I254	R:R:Q250	5.49	No	No	3	8	8
190	R:R:Q250	R:R:R308	25.7	No	No	0	8	9
191	R:R:I254	R:R:Y304	12.09	No	Yes	0	8	9
192	R:R:V257	R:R:V303	3.21	No	No	0	7	8
193	R:R:L266	R:R:W262	5.69	No	Yes	0	7	9
194	R:R:A293	R:R:W262	7.78	No	Yes	0	8	9
195	R:R:N296	R:R:W262	10.17	No	Yes	1	9	9
196	R:R:Q297	R:R:W262	4.38	Yes	Yes	1	8	9
197	R:R:P264	R:R:S263	3.56	No	No	0	9	5
198	R:R:F265	R:R:M269	7.46	Yes	No	0	8	7
199	R:R:A289	R:R:F265	4.16	No	Yes	0	7	8
200	R:R:F265	R:R:L290	3.65	Yes	Yes	1	8	7
201	R:R:N271	R:R:V267	4.43	No	No	0	4	6
202	R:R:E281	R:R:T268	12.7	No	No	0	1	5
203	R:R:N271	R:R:N275	4.09	No	No	0	4	1
204	R:R:I274	R:R:N275	5.66	No	No	0	3	1
205	R:R:E281	R:R:T285	11.29	No	No	0	1	2
206	R:R:E281	R:R:T286	4.23	No	No	0	1	7
207	R:R:L287	R:R:R291	9.72	No	Yes	1	6	8
208	R:R:F288	R:R:M292	9.95	No	No	0	4	6
209	R:R:I298	R:R:W295	9.4	No	No	0	8	5
210	R:R:L299	R:R:W295	5.69	No	No	0	7	5
211	R:R:N296	R:R:Q297	5.28	No	Yes	1	9	8
212	R:R:D300	R:R:N296	12.12	No	No	0	9	9
213	R:R:L299	R:R:W302	3.42	No	Yes	0	7	6
214	R:R:D300	R:R:Y304	9.2	No	Yes	0	9	9
215	R:R:L306	R:R:W302	19.36	No	Yes	0	8	6
216	R:R:L307	R:R:W302	5.69	No	Yes	0	6	6
217	R:R:V303	R:R:Y304	3.79	No	Yes	0	8	9
218	R:R:K317	R:R:Q321	10.85	No	No	0	4	3
219	R:R:T138	R:R:T226	3.14	No	No	0	7	6
220	R:R:I75	R:R:S71	3.1	No	No	0	6	6
221	R:R:I171	R:R:S109	3.1	No	No	0	4	4
222	R:R:I131	R:R:S127	3.1	No	No	0	6	7
223	R:R:M269	R:R:S206	3.07	No	No	0	7	7
224	R:R:M155	R:R:V159	3.04	No	No	0	5	5
225	R:R:I272	R:R:T190	3.04	No	No	0	6	7
226	R:R:I272	R:R:T268	3.04	No	No	0	6	5
227	R:R:L51	R:R:S71	3	Yes	No	0	8	6
228	R:R:L213	R:R:S258	3	No	No	0	8	9
229	R:R:L51	R:R:V74	2.98	Yes	Yes	0	8	8
230	R:R:L227	R:R:V137	2.98	Yes	No	0	8	8
231	R:R:L168	R:R:V164	2.98	No	No	0	4	4
232	R:R:Y188	R:R:Y201	2.98	Yes	No	0	6	6
233	R:R:L211	R:R:V215	2.98	No	No	0	4	5
234	R:R:L227	R:R:V248	2.98	Yes	No	0	8	7
235	R:R:L252	R:R:V248	2.98	No	No	0	5	7
236	R:R:L42	R:R:T38	2.95	No	No	0	4	5
237	R:R:L251	R:R:T223	2.95	No	Yes	0	8	8
238	R:R:I305	R:R:I50	2.94	No	No	0	8	8
239	R:R:I135	R:R:I147	2.94	No	No	0	5	5
240	R:R:Q236	R:R:S234	2.89	No	No	0	3	4
241	R:R:K150	R:R:M154	2.88	No	No	0	5	3
242	R:R:I41	R:R:L82	2.85	Yes	No	0	6	5
243	R:R:I193	R:R:N189	2.83	No	No	0	1	6
244	R:R:E284	R:R:T282	2.82	No	No	0	1	4
245	R:R:K313	R:R:N314	2.8	No	No	0	4	5
246	R:R:L306	R:R:L46	2.77	No	No	0	8	5
247	R:R:A163	R:R:F117	2.77	No	No	0	7	7
248	R:R:A64	R:R:Y55	2.67	No	No	0	7	6
249	R:R:H151	R:R:K150	2.62	No	No	0	5	5
250	R:R:D95	R:R:E97	2.6	No	No	0	4	4
251	R:R:D192	R:R:E191	2.6	No	No	0	2	3
252	R:R:F66	R:R:L67	2.44	Yes	Yes	0	7	8
253	R:R:F90	R:R:L107	2.44	No	No	2	5	5
254	R:R:F101	R:R:L107	2.44	Yes	No	2	4	5
255	R:R:F207	R:R:L208	2.44	No	Yes	0	4	5
256	R:R:F207	R:R:L211	2.44	No	No	0	4	4
257	R:R:Q60	R:R:R59	2.34	No	No	0	5	5
258	R:R:F58	R:R:R57	2.14	No	No	0	4	4
259	R:R:G72	R:R:S71	1.86	No	No	0	8	6
260	R:R:G158	R:R:S157	1.86	No	No	0	1	3
261	R:R:G224	R:R:T223	1.82	No	Yes	0	7	8
262	R:R:C322	R:R:C323	1.82	No	No	0	5	5
263	R:R:G240	R:R:K231	1.74	No	No	0	4	6
264	R:R:G126	R:R:L73	1.71	No	No	0	8	9
265	R:R:G158	R:R:L161	1.71	No	No	0	1	3
266	R:R:G273	R:R:L203	1.71	No	No	0	4	4
267	R:R:G214	R:R:L213	1.71	No	No	0	3	8
268	R:R:G214	R:R:L217	1.71	No	No	0	3	5
269	R:R:C261	R:R:V257	1.71	No	No	0	8	7
270	R:R:M292	R:R:P264	1.68	No	No	0	6	9
271	R:R:K139	R:R:P140	1.67	No	No	0	5	8
272	R:R:C114	R:R:I110	1.64	No	No	0	4	5
273	R:R:C256	R:R:I260	1.64	No	No	0	5	5
274	R:R:S263	R:R:V267	1.62	No	No	0	5	6
275	R:R:V30	R:R:V34	1.6	No	No	0	6	4
276	R:R:V34	R:R:V89	1.6	No	No	0	4	6
277	R:R:T38	R:R:V39	1.59	No	No	0	5	6
278	R:R:G173	R:R:H174	1.59	No	No	0	7	4
279	R:R:A319	R:R:L318	1.58	No	No	0	5	4
280	R:R:T282	R:R:T285	1.57	No	No	0	4	2
281	R:R:A310	R:R:N314	1.56	No	No	0	7	5
282	R:R:I41	R:R:S45	1.55	Yes	No	0	6	5
283	R:R:I35	R:R:V39	1.54	No	No	0	4	6
284	R:R:I87	R:R:V91	1.54	No	No	0	6	7
285	R:R:K233	R:R:S234	1.53	No	No	0	5	4
286	R:R:L68	R:R:S149	1.5	No	No	0	6	3
287	R:R:K150	R:R:T148	1.5	No	No	0	5	7
288	R:R:L69	R:R:V128	1.49	Yes	No	0	7	7
289	R:R:L124	R:R:V159	1.49	No	No	0	5	5
290	R:R:L125	R:R:V128	1.49	No	No	0	7	7
291	R:R:N275	R:R:S279	1.49	No	No	0	1	1
292	R:R:G173	R:R:Y201	1.45	No	No	0	7	6
293	R:R:Q103	R:R:S104	1.44	No	No	0	4	5
294	R:R:K309	R:R:K313	1.44	No	No	0	7	4
295	R:R:Q321	R:R:S320	1.44	No	No	0	3	5
296	R:R:E191	R:R:T190	1.41	No	No	0	3	7
297	R:R:L227	R:R:M247	1.41	Yes	No	0	8	8
298	R:R:D192	R:R:K194	1.38	No	No	0	2	1
299	R:R:H244	R:R:V230	1.38	No	No	0	8	7
300	R:R:L307	R:R:L312	1.38	No	No	0	6	7
301	R:R:L315	R:R:L318	1.38	No	No	0	4	4
302	R:R:E97	R:R:I99	1.37	No	No	0	4	1
303	R:R:E191	R:R:N277	1.31	No	No	0	3	1
304	R:R:Q235	R:R:Q236	1.28	No	No	0	2	3
305	R:R:F142	R:R:I141	1.26	Yes	No	0	4	5
306	R:R:K53	R:R:R57	1.24	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.37737	19	1	0
2	R:R:I41	3.135	4	0	6
3	R:R:L51	4.8175	4	0	8
4	R:R:F66	4.3325	4	0	7
5	R:R:L67	3.4925	4	0	8
6	R:R:L69	4.5825	4	0	7
7	R:R:V74	4.6475	4	0	8
8	R:R:Y92	8.6175	4	1	8
9	R:R:W98	10.6975	4	2	5
10	R:R:F101	7.83	5	2	4
11	R:R:F111	9.1625	4	1	6
12	R:R:M115	6.5275	4	1	8
13	R:R:V116	6.26	4	1	8
14	R:R:E132	6.5625	4	0	9
15	R:R:R133	4.925	4	3	9
16	R:R:F142	6.845	4	0	4
17	R:R:H143	6.0025	4	0	8
18	R:R:Y177	6.815	6	1	7
19	R:R:T184	7.866	5	1	9
20	R:R:W185	6.80167	6	1	8
21	R:R:F187	5.68857	7	1	8
22	R:R:Y188	7.14857	7	1	6
23	R:R:L208	4.534	5	5	5
24	R:R:N220	5.095	4	6	9
25	R:R:T223	3.2275	4	0	8
26	R:R:L227	2.8075	4	0	8
27	R:R:W262	8.89167	6	1	9
28	R:R:F265	5.0025	4	1	8
29	R:R:L290	5.19	4	1	7
30	R:R:R291	8.83	4	1	8
31	R:R:Q297	5.506	5	1	8
32	R:R:W302	8.6625	4	0	6
33	R:R:Y304	7.1675	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R291	40.194	3.15	Yes	Yes	1	0	8
2	R:R:F36	R:R:R291	38.5657	4.28	No	Yes	0	8	8
3	L:L:?1	R:R:T294	39.2124	5.73	Yes	No	0	0	9
4	R:R:F36	R:R:T294	38.3385	5.19	No	No	0	8	9
5	R:R:F36	R:R:W295	75.0255	11.02	No	No	0	8	5
6	R:R:L299	R:R:W295	59.6691	5.69	No	No	0	7	5
7	R:R:L299	R:R:W302	57.7525	3.42	No	Yes	0	7	6
8	R:R:L306	R:R:W302	50.4762	19.36	No	Yes	0	8	6
9	R:R:A47	R:R:L306	46.5439	3.15	No	No	0	9	8
10	R:R:A47	R:R:V74	44.569	5.09	No	Yes	0	9	8
11	R:R:N44	R:R:V74	16.6584	5.91	No	Yes	0	9	8
12	R:R:F78	R:R:N44	12.528	6.04	No	No	0	7	9
13	R:R:I298	R:R:W295	14.3282	9.4	No	No	0	8	5
14	R:R:L51	R:R:V74	22.4608	2.98	Yes	Yes	0	8	8
15	R:R:I305	R:R:L51	12.1785	8.56	No	Yes	0	8	8
16	R:R:I305	R:R:I50	10.1046	2.94	No	No	0	8	8
17	L:L:?1	R:R:W262	52.5007	3.69	Yes	Yes	1	0	9
18	R:R:N296	R:R:W262	50.5025	10.17	No	Yes	1	9	9
19	R:R:D300	R:R:N296	100	12.12	No	No	0	9	9
20	R:R:D300	R:R:Y304	99.0329	9.2	No	Yes	0	9	9
21	R:R:M129	R:R:Y304	48.548	3.59	No	Yes	0	9	9
22	R:R:F66	R:R:M129	32.4372	4.98	Yes	No	0	7	9
23	R:R:F66	R:R:L67	18.0915	2.44	Yes	Yes	0	7	8
24	L:L:?1	R:R:Q297	56.8786	3.45	Yes	Yes	1	0	8
25	R:R:N296	R:R:Q297	50.4937	5.28	No	Yes	1	9	8
26	R:R:A64	R:R:L67	10.7425	4.73	No	Yes	0	7	8
27	R:R:E132	R:R:F66	19.4518	3.5	Yes	Yes	0	9	7
28	R:R:E132	R:R:H143	29.7428	7.39	Yes	Yes	0	9	8
29	R:R:L69	R:R:M129	20.3548	7.07	Yes	No	0	7	9
30	R:R:E132	R:R:L69	20.0693	5.3	Yes	Yes	0	9	7
31	L:L:?1	R:R:F111	19.58	3.16	Yes	Yes	1	0	6
32	R:R:F111	R:R:I87	22.2277	18.84	Yes	No	0	6	6
33	R:R:I87	R:R:V91	20.882	1.54	No	No	0	6	7
34	R:R:F101	R:R:V91	11.159	7.87	Yes	No	2	4	7
35	L:L:?1	R:R:F187	51.2219	5.53	Yes	Yes	1	0	8
36	R:R:F187	R:R:Y188	25.0299	10.32	Yes	Yes	1	8	6
37	R:R:Y188	R:R:Y201	16.3264	2.98	Yes	No	0	6	6
38	R:R:F200	R:R:Y201	13.364	4.13	No	No	0	5	6
39	R:R:F200	R:R:W196	12.3649	8.02	No	No	0	5	1
40	R:R:D195	R:R:W196	11.36	5.58	No	No	0	1	1
41	R:R:D195	R:R:E197	10.3492	7.8	No	No	0	1	2
42	R:R:F187	R:R:V116	10.7163	5.24	Yes	Yes	1	8	8
43	R:R:F205	R:R:L120	12.8863	4.87	No	No	0	8	6
44	R:R:I254	R:R:Y304	47.5838	12.09	No	Yes	0	8	9
45	R:R:I254	R:R:R133	37.4705	3.76	No	Yes	3	8	9
46	R:R:L251	R:R:R133	42.6786	4.86	No	Yes	0	8	9
47	R:R:L251	R:R:N220	17.9284	4.12	No	Yes	0	8	9
48	R:R:L251	R:R:T223	25.426	2.95	No	Yes	0	8	8
49	R:R:T223	R:R:V137	17.6313	4.76	Yes	No	0	8	8
50	R:R:H143	R:R:I147	22.9996	5.3	Yes	No	0	8	5
51	R:R:F142	R:R:I147	18.409	5.02	Yes	No	0	4	5
52	L:L:?1	R:R:W185	14.101	5.17	Yes	Yes	1	0	8
53	R:R:Q180	R:R:W185	12.9096	13.14	No	Yes	1	8	8
54	R:R:F187	R:R:Q180	16.0525	3.51	Yes	No	1	8	8
55	R:R:Q180	R:R:T190	26.7717	9.92	No	No	0	8	7
56	R:R:M255	R:R:N220	13.5242	5.61	No	Yes	0	8	9
57	R:R:L217	R:R:M255	10.559	4.24	No	No	0	5	8
58	R:R:L227	R:R:V137	16.1661	2.98	Yes	No	0	8	8
59	R:R:I272	R:R:T190	15.7176	3.04	No	No	0	6	7
60	R:R:I272	R:R:T268	13.4893	3.04	No	No	0	6	5
61	R:R:E281	R:R:T268	11.2551	12.7	No	No	0	1	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S33	8.76	1	Yes	No	0	7	0	1
L:L:?1	R:R:H81	20	1	Yes	No	0	8	0	1
L:L:?1	R:R:N84	7.12	1	Yes	No	0	6	0	1
L:L:?1	R:R:G85	4.43	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y92	6.84	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F111	3.16	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:M115	11.91	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S118	3.89	1	Yes	No	0	7	0	1
L:L:?1	R:R:G119	3.33	1	Yes	No	0	7	0	1
L:L:?1	R:R:T184	8.6	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:W185	5.17	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F187	5.53	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W262	3.69	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F265	4.74	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L287	4.49	1	Yes	No	0	6	0	1
L:L:?1	R:R:L290	7.18	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R291	3.15	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T294	5.73	1	Yes	No	0	9	0	1
L:L:?1	R:R:Q297	3.45	1	Yes	Yes	0	8	0	1
R:R:S29	R:R:Y92	3.82	0	No	Yes	7	8	2	1
R:R:V30	R:R:Y92	8.83	0	No	Yes	6	8	2	1
R:R:F32	R:R:R291	18.17	0	No	Yes	4	8	2	1
R:R:A88	R:R:S33	3.42	0	No	No	8	7	2	1
R:R:F36	R:R:R291	4.28	0	No	Yes	8	8	2	1
R:R:F36	R:R:T294	5.19	0	No	No	8	9	2	1
R:R:G80	R:R:S118	3.71	0	No	No	8	7	2	1
R:R:H81	R:R:Q297	4.95	1	No	Yes	8	8	1	1
R:R:F111	R:R:N84	9.67	1	Yes	No	6	6	1	1
R:R:C114	R:R:N84	4.72	0	No	No	4	6	2	1
R:R:F111	R:R:I87	18.84	1	Yes	No	6	6	1	2
R:R:T184	R:R:Y92	14.98	1	Yes	Yes	9	8	1	1
R:R:K96	R:R:T184	4.5	0	No	Yes	5	9	2	1
R:R:F111	R:R:M115	4.98	1	Yes	Yes	6	8	1	1
R:R:F187	R:R:M115	4.98	1	Yes	Yes	8	8	1	1
R:R:L290	R:R:M115	4.24	1	Yes	Yes	7	8	1	1
R:R:F187	R:R:V116	5.24	1	Yes	Yes	8	8	1	2
R:R:V116	R:R:Y188	11.36	1	Yes	Yes	8	6	2	2
R:R:P122	R:R:Q297	9.47	0	No	Yes	9	8	2	1
R:R:L123	R:R:W262	21.64	0	No	Yes	7	9	2	1
R:R:Q180	R:R:W185	13.14	1	No	Yes	8	8	2	1
R:R:F187	R:R:Q180	3.51	1	Yes	No	8	8	1	2
R:R:S182	R:R:T184	6.4	1	No	Yes	8	9	2	1
R:R:S182	R:R:W185	4.94	1	No	Yes	8	8	2	1
R:R:T184	R:R:W185	4.85	1	Yes	Yes	9	8	1	1
R:R:F187	R:R:W185	7.02	1	Yes	Yes	8	8	1	1
R:R:L290	R:R:W185	5.69	1	Yes	Yes	7	8	1	1
R:R:F187	R:R:Y188	10.32	1	Yes	Yes	8	6	1	2
R:R:F187	R:R:F205	3.22	1	Yes	No	8	8	1	2
R:R:F205	R:R:Y188	6.19	1	No	Yes	8	6	2	2
R:R:L266	R:R:W262	5.69	0	No	Yes	7	9	2	1
R:R:A293	R:R:W262	7.78	0	No	Yes	8	9	2	1
R:R:N296	R:R:W262	10.17	1	No	Yes	9	9	2	1
R:R:Q297	R:R:W262	4.38	1	Yes	Yes	8	9	1	1
R:R:F265	R:R:M269	7.46	1	Yes	No	8	7	1	2
R:R:A289	R:R:F265	4.16	0	No	Yes	7	8	2	1
R:R:F265	R:R:L290	3.65	1	Yes	Yes	8	7	1	1
R:R:L287	R:R:R291	9.72	1	No	Yes	6	8	1	1
R:R:N296	R:R:Q297	5.28	1	No	Yes	9	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IUL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	281
Number of Links	306
Number of Hubs	33
Number of Links mediated by Hubs	131
Number of Communities	6
Number of Nodes involved in Communities	40
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	66144
Length Of Smallest Path	3
Average Path Length	13.851
Length of Longest Path	28
Minimum Path Strength	1.36
Average Path Strength	6.39979
Maximum Path Strength	15.955
Minimum Path Correlation	0.7
Average Path Correlation	0.9292
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	52.0553
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.0142
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7WT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7WT
Name	Latanoprost acid
Synonyms	7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]hept-5-enoic acid
Identifier
Formula	C23 H34 O5
Molecular Weight	390.513
SMILES
PubChem	6441636
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	5
Total Bonds	63
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43088
Sequence	>8IUL_nogp_Chain_R S V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q K S K A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D K E W I R F D Q S N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K P I F H S T K I T S K H V K M M L S G V C L F A V F I A L L P I L G H R D Y K I Q A S R T W C F Y N T E D I K D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q Q H G R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N G N H S L E T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A V L K N L Y K L A S Q C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XJK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-		2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.85	2024-02-28	To be published
	8XJM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.85	2024-02-28	To be published
	8XJL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.77	2024-02-28	To be published
	8XJL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.77	2024-02-28	To be published
	8IQ6	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ6 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-		2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IUM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-		3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.67	2023-07-12	10.1038/s41467-023-38411-x
	8IUK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.67	2023-07-12	10.1038/s41467-023-38411-x

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