psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S33	5.84	Yes	No	0	0	7
2	L:L:?1	R:R:F36	3.16	Yes	Yes	1	0	8
3	L:L:?1	R:R:H81	12.5	Yes	No	1	0	8
4	L:L:?1	R:R:N84	5.34	Yes	Yes	1	0	6
5	L:L:?1	R:R:G85	4.43	Yes	No	0	0	7
6	L:L:?1	R:R:A88	3.06	Yes	No	0	0	8
7	L:L:?1	R:R:Y92	4.56	Yes	Yes	1	0	8
8	L:L:?1	R:R:M115	10.99	Yes	Yes	1	0	8
9	L:L:?1	R:R:T184	7.64	Yes	Yes	1	0	9
10	L:L:?1	R:R:W185	3.69	Yes	Yes	1	0	8
11	L:L:?1	R:R:W262	3.69	Yes	Yes	1	0	9
12	L:L:?1	R:R:F265	5.53	Yes	Yes	1	0	8
13	L:L:?1	R:R:L290	10.76	Yes	No	1	0	7
14	L:L:?1	R:R:T294	7.64	Yes	No	1	0	9
15	L:L:?1	R:R:Q297	4.31	Yes	Yes	1	0	8
16	R:R:S33	R:R:V30	3.23	No	Yes	0	7	6
17	R:R:V30	R:R:V89	3.21	Yes	No	0	6	6
18	R:R:V30	R:R:Y92	11.36	Yes	Yes	0	6	8
19	R:R:F32	R:R:R291	10.69	No	No	0	4	8
20	R:R:I35	R:R:V39	3.07	No	No	0	4	6
21	R:R:F36	R:R:T294	5.19	Yes	No	1	8	9
22	R:R:F36	R:R:W295	8.02	Yes	No	1	8	5
23	R:R:F36	R:R:I298	5.02	Yes	No	1	8	8
24	R:R:G85	R:R:M37	3.49	No	No	0	7	7
25	R:R:L42	R:R:T38	2.95	No	No	0	4	5
26	R:R:I298	R:R:V39	6.14	No	No	0	8	6
27	R:R:G40	R:R:H81	3.18	No	No	0	9	8
28	R:R:F78	R:R:I41	5.02	No	No	0	7	6
29	R:R:S43	R:R:W302	8.65	No	No	0	9	6
30	R:R:N44	R:R:V74	2.96	Yes	No	0	9	8
31	R:R:D77	R:R:N44	6.73	Yes	Yes	0	9	9
32	R:R:F78	R:R:N44	4.83	No	Yes	0	7	9
33	R:R:N44	R:R:P301	8.15	Yes	No	0	9	9
34	R:R:A47	R:R:V74	3.39	No	No	0	9	8
35	R:R:I48	R:R:V74	4.61	No	No	0	7	8
36	R:R:I50	R:R:V311	4.61	No	No	0	8	7
37	R:R:L51	R:R:S71	6.01	No	No	0	8	6
38	R:R:I305	R:R:L51	5.71	Yes	No	0	8	8
39	R:R:R59	R:R:Y55	12.35	No	No	0	5	6
40	R:R:L67	R:R:Y55	3.52	Yes	No	0	8	6
41	R:R:Q56	R:R:R59	8.18	No	No	0	4	5
42	R:R:F58	R:R:R57	5.34	No	No	0	4	4
43	R:R:F58	R:R:L67	3.65	No	Yes	0	4	8
44	R:R:H143	R:R:K63	3.93	Yes	No	2	8	6
45	R:R:I147	R:R:K63	7.27	No	No	2	5	6
46	R:R:A64	R:R:L67	4.73	No	Yes	0	7	8
47	R:R:E132	R:R:S65	11.5	No	No	0	9	7
48	R:R:S65	R:R:V152	4.85	No	No	0	7	7
49	R:R:F66	R:R:L67	3.65	No	Yes	0	7	8
50	R:R:F66	R:R:M129	4.98	No	Yes	0	7	9
51	R:R:F66	R:R:R133	5.34	No	Yes	0	7	9
52	R:R:L68	R:R:V152	2.98	No	No	0	6	7
53	R:R:L69	R:R:V128	2.98	No	No	0	7	7
54	R:R:L69	R:R:M129	5.65	No	Yes	0	7	9
55	R:R:E132	R:R:L69	5.3	No	No	0	9	7
56	R:R:G72	R:R:L156	3.42	No	No	0	8	7
57	R:R:D77	R:R:L73	8.14	Yes	No	0	9	9
58	R:R:L73	R:R:Y304	3.52	No	Yes	0	9	9
59	R:R:C121	R:R:T76	6.76	Yes	No	0	7	8
60	R:R:P122	R:R:T76	3.5	No	No	0	9	8
61	R:R:D77	R:R:P122	3.22	Yes	No	1	9	9
62	R:R:D77	R:R:Q297	3.92	Yes	Yes	1	9	8
63	R:R:D300	R:R:D77	3.99	No	Yes	0	9	9
64	R:R:G80	R:R:S118	3.71	No	No	0	8	7
65	R:R:H81	R:R:Q297	3.71	No	Yes	1	8	8
66	R:R:C114	R:R:I83	3.27	No	No	0	4	5
67	R:R:F111	R:R:N84	4.83	Yes	Yes	1	6	6
68	R:R:C114	R:R:N84	4.72	No	Yes	0	4	6
69	R:R:M115	R:R:N84	9.82	Yes	Yes	1	8	6
70	R:R:N84	R:R:S118	4.47	Yes	No	0	6	7
71	R:R:F111	R:R:I87	18.84	Yes	No	0	6	6
72	R:R:F90	R:R:S94	3.96	No	No	0	5	4
73	R:R:V91	R:R:W98	12.26	No	Yes	0	7	5
74	R:R:K96	R:R:Y92	3.58	No	Yes	1	5	8
75	R:R:T184	R:R:Y92	7.49	Yes	Yes	1	9	8
76	R:R:F101	R:R:S94	5.28	No	No	0	4	4
77	R:R:K96	R:R:T184	3	No	Yes	1	5	9
78	R:R:E97	R:R:I99	6.83	No	No	0	4	1
79	R:R:F101	R:R:W98	11.02	No	Yes	0	4	5
80	R:R:L107	R:R:W98	3.42	No	Yes	0	5	5
81	R:R:I179	R:R:W98	11.74	No	Yes	5	5	5
82	R:R:R183	R:R:W98	3	No	Yes	5	6	5
83	R:R:C186	R:R:W98	3.92	No	Yes	0	9	5
84	R:R:I99	R:R:R100	3.76	No	No	0	1	1
85	R:R:D102	R:R:N105	5.39	No	No	0	4	1
86	R:R:D102	R:R:L107	6.79	No	No	0	4	5
87	R:R:S104	R:R:V106	3.23	No	No	0	5	3
88	R:R:I110	R:R:V106	3.07	No	No	0	5	3
89	R:R:C108	R:R:C186	7.28	No	No	0	9	9
90	R:R:I171	R:R:S109	3.1	No	No	0	4	4
91	R:R:F111	R:R:M115	4.98	Yes	Yes	1	6	8
92	R:R:G112	R:R:Y177	4.35	No	Yes	0	7	7
93	R:R:I113	R:R:Y177	6.04	No	Yes	0	5	7
94	R:R:L290	R:R:M115	4.24	No	Yes	1	7	8
95	R:R:A167	R:R:V116	3.39	No	Yes	0	8	8
96	R:R:V116	R:R:Y177	5.05	Yes	Yes	1	8	7
97	R:R:F187	R:R:V116	3.93	Yes	Yes	1	8	8
98	R:R:V116	R:R:Y188	3.79	Yes	Yes	1	8	6
99	R:R:C121	R:R:F117	6.98	Yes	No	0	7	7
100	R:R:F205	R:R:L120	7.31	No	No	0	8	6
101	R:R:C121	R:R:L125	3.17	Yes	No	0	7	7
102	R:R:A163	R:R:C121	3.61	No	Yes	0	7	7
103	R:R:P122	R:R:Q297	11.05	No	Yes	1	9	8
104	R:R:L123	R:R:W262	14.81	No	Yes	0	7	9
105	R:R:L125	R:R:V159	4.47	No	No	0	7	5
106	R:R:G126	R:R:M129	3.49	No	Yes	0	8	9
107	R:R:S127	R:R:V215	4.85	No	No	0	7	5
108	R:R:M129	R:R:Y304	8.38	Yes	Yes	0	9	9
109	R:R:A130	R:R:S216	3.42	No	No	6	9	8
110	R:R:A130	R:R:N220	4.69	No	Yes	6	9	9
111	R:R:I131	R:R:V215	3.07	No	No	0	6	5
112	R:R:C219	R:R:I131	3.27	No	No	0	7	6
113	R:R:E132	R:R:H143	4.92	No	Yes	0	9	8
114	R:R:M247	R:R:R133	3.72	No	Yes	3	8	9
115	R:R:Q250	R:R:R133	5.84	Yes	Yes	3	8	9
116	R:R:L251	R:R:R133	3.64	No	Yes	0	8	9
117	R:R:I254	R:R:R133	3.76	Yes	Yes	3	8	9
118	R:R:R133	R:R:Y304	6.17	Yes	Yes	3	9	9
119	R:R:C134	R:R:T138	3.38	Yes	No	0	6	7
120	R:R:C134	R:R:C219	3.64	Yes	No	0	6	7
121	R:R:C134	R:R:I222	3.27	Yes	No	0	6	4
122	R:R:C134	R:R:T223	3.38	Yes	Yes	0	6	8
123	R:R:G136	R:R:I135	3.53	No	No	2	8	5
124	R:R:H143	R:R:I135	3.98	Yes	No	2	8	5
125	R:R:G136	R:R:H143	9.53	No	Yes	2	8	8
126	R:R:T223	R:R:V137	4.76	Yes	No	7	8	8
127	R:R:L227	R:R:V137	4.47	Yes	No	7	8	8
128	R:R:T138	R:R:T226	3.14	No	No	0	7	6
129	R:R:F142	R:R:K139	9.93	No	No	0	4	5
130	R:R:I141	R:R:T145	3.04	No	No	0	5	5
131	R:R:F142	R:R:K146	7.44	No	No	0	4	4
132	R:R:H143	R:R:I147	5.3	Yes	No	2	8	5
133	R:R:K146	R:R:T145	7.51	No	No	0	4	5
134	R:R:H151	R:R:T148	6.85	No	No	0	5	7
135	R:R:K150	R:R:S149	6.12	No	No	0	5	3
136	R:R:G158	R:R:S157	3.71	No	No	0	1	3
137	R:R:F162	R:R:I166	11.3	No	Yes	0	4	6
138	R:R:F165	R:R:I166	3.77	No	Yes	0	3	6
139	R:R:F165	R:R:L169	3.65	No	No	0	3	6
140	R:R:L168	R:R:L172	6.92	No	No	0	4	4
141	R:R:P170	R:R:Y177	15.3	No	Yes	1	9	7
142	R:R:P170	R:R:Y188	5.56	No	Yes	1	9	6
143	R:R:E197	R:R:R175	5.82	No	No	0	2	8
144	R:R:Y177	R:R:Y188	6.95	Yes	Yes	1	7	6
145	R:R:K178	R:R:N189	19.58	No	No	0	5	6
146	R:R:I179	R:R:R183	7.52	No	No	5	5	6
147	R:R:Q180	R:R:W185	20.81	No	Yes	1	8	8
148	R:R:F187	R:R:Q180	5.86	Yes	No	1	8	8
149	R:R:Q180	R:R:T190	11.34	No	No	0	8	7
150	R:R:A181	R:R:E191	6.03	No	No	0	4	3
151	R:R:S182	R:R:W185	4.94	No	Yes	0	8	8
152	R:R:L287	R:R:S182	7.51	No	No	0	6	8
153	R:R:T184	R:R:W185	3.64	Yes	Yes	1	9	8
154	R:R:F187	R:R:W185	7.02	Yes	Yes	1	8	8
155	R:R:L290	R:R:W185	11.39	No	Yes	1	7	8
156	R:R:F187	R:R:Y188	8.25	Yes	Yes	1	8	6
157	R:R:F187	R:R:F205	5.36	Yes	No	1	8	8
158	R:R:F187	R:R:M269	3.73	Yes	No	0	8	7
159	R:R:Y188	R:R:Y201	3.97	Yes	No	0	6	6
160	R:R:L202	R:R:Y188	3.52	Yes	Yes	0	6	6
161	R:R:F205	R:R:Y188	5.16	No	Yes	1	8	6
162	R:R:D192	R:R:N189	14.81	No	No	8	2	6
163	R:R:K194	R:R:N189	5.6	No	No	8	1	6
164	R:R:D192	R:R:K194	17.97	No	No	8	2	1
165	R:R:D198	R:R:K194	4.15	No	No	0	5	1
166	R:R:D195	R:R:W196	16.75	No	No	0	1	1
167	R:R:D198	R:R:L202	4.07	No	Yes	0	5	6
168	R:R:G273	R:R:L202	3.42	No	Yes	0	4	6
169	R:R:L210	R:R:S206	3	No	No	0	5	7
170	R:R:A270	R:R:S206	3.42	No	No	0	5	7
171	R:R:F207	R:R:L211	4.87	No	No	0	4	4
172	R:R:G209	R:R:L266	5.13	No	No	0	7	7
173	R:R:L213	R:R:S258	3	Yes	No	0	8	9
174	R:R:N220	R:R:S216	4.47	Yes	No	6	9	8
175	R:R:L217	R:R:M255	7.07	No	No	0	5	8
176	R:R:C259	R:R:L217	3.17	No	No	0	5	5
177	R:R:L251	R:R:N220	4.12	No	Yes	0	8	9
178	R:R:M255	R:R:N220	7.01	No	Yes	0	8	9
179	R:R:L227	R:R:T223	2.95	Yes	Yes	7	8	8
180	R:R:L251	R:R:T223	2.95	No	Yes	0	8	8
181	R:R:H244	R:R:L227	5.14	No	Yes	0	8	8
182	R:R:L228	R:R:V248	2.98	No	No	0	5	7
183	R:R:E246	R:R:R308	9.3	No	No	0	7	9
184	R:R:E246	R:R:K309	6.75	No	No	0	7	7
185	R:R:M247	R:R:Q250	6.8	No	Yes	3	8	8
186	R:R:I254	R:R:Q250	4.12	Yes	Yes	3	8	8
187	R:R:Q250	R:R:R308	21.03	Yes	No	0	8	9
188	R:R:I254	R:R:V303	3.07	Yes	No	0	8	8
189	R:R:I254	R:R:Y304	13.3	Yes	Yes	3	8	9
190	R:R:C256	R:R:V257	3.42	No	No	0	5	7
191	R:R:C261	R:R:N296	3.15	No	No	0	8	9
192	R:R:F265	R:R:W262	6.01	Yes	Yes	1	8	9
193	R:R:A293	R:R:W262	6.48	No	Yes	0	8	9
194	R:R:N296	R:R:W262	15.82	No	Yes	0	9	9
195	R:R:Q297	R:R:W262	5.48	Yes	Yes	1	8	9
196	R:R:P264	R:R:S263	5.34	No	No	0	9	5
197	R:R:M292	R:R:P264	3.35	No	No	0	6	9
198	R:R:F265	R:R:M269	7.46	Yes	No	0	8	7
199	R:R:A289	R:R:F265	4.16	No	Yes	0	7	8
200	R:R:N271	R:R:N275	5.45	No	Yes	4	4	1
201	R:R:L280	R:R:N271	5.49	Yes	No	4	2	4
202	R:R:I272	R:R:N277	4.25	No	No	4	6	1
203	R:R:I272	R:R:L280	9.99	No	Yes	4	6	2
204	R:R:I274	R:R:N275	4.25	No	Yes	0	3	1
205	R:R:L280	R:R:N275	9.61	Yes	Yes	4	2	1
206	R:R:L280	R:R:N277	9.61	Yes	No	4	2	1
207	R:R:E281	R:R:T285	7.06	No	No	0	1	2
208	R:R:T282	R:R:T285	4.71	No	No	0	4	2
209	R:R:F288	R:R:R291	4.28	No	No	0	4	8
210	R:R:F288	R:R:M292	6.22	No	No	0	4	6
211	R:R:I298	R:R:W295	3.52	No	No	1	8	5
212	R:R:L299	R:R:W295	4.56	No	No	0	7	5
213	R:R:D300	R:R:N296	9.42	No	No	0	9	9
214	R:R:D300	R:R:Y304	3.45	No	Yes	0	9	9
215	R:R:L306	R:R:W302	12.53	No	No	0	8	6
216	R:R:I113	R:R:I171	2.94	No	No	0	5	4
217	R:R:I113	R:R:L168	2.85	No	No	0	5	4
218	R:R:I166	R:R:L120	2.85	Yes	No	0	6	6
219	R:R:I166	R:R:L204	2.85	Yes	No	0	6	4
220	R:R:I171	R:R:L172	2.85	No	No	0	4	4
221	R:R:I272	R:R:L202	2.85	No	Yes	0	6	6
222	R:R:I305	R:R:L306	2.85	Yes	No	0	8	8
223	R:R:E191	R:R:T190	2.82	No	No	0	3	7
224	R:R:E284	R:R:T282	2.82	No	No	0	1	4
225	R:R:G119	R:R:W262	2.81	No	Yes	0	7	9
226	R:R:D192	R:R:I193	2.8	No	No	0	2	1
227	R:R:C186	R:R:F111	2.79	No	Yes	0	9	6
228	R:R:L28	R:R:L287	2.77	No	No	0	4	6
229	R:R:L306	R:R:L46	2.77	No	No	0	8	5
230	R:R:L51	R:R:L67	2.77	No	Yes	0	8	8
231	R:R:L123	R:R:L213	2.77	No	Yes	0	7	8
232	R:R:L125	R:R:L156	2.77	No	No	0	7	7
233	R:R:D176	R:R:K178	2.77	No	No	0	3	5
234	R:R:L210	R:R:L266	2.77	No	No	0	5	7
235	R:R:L213	R:R:L266	2.77	Yes	No	0	8	7
236	R:R:F79	R:R:I75	2.51	No	No	0	5	6
237	R:R:F142	R:R:I135	2.51	No	No	0	4	5
238	R:R:F78	R:R:L82	2.44	No	No	0	7	5
239	R:R:F162	R:R:L124	2.44	No	No	0	4	5
240	R:R:F162	R:R:L208	2.44	No	No	0	4	5
241	R:R:T286	R:R:W185	2.43	No	Yes	0	7	8
242	R:R:L307	R:R:R308	2.43	No	No	0	6	9
243	R:R:D198	R:R:R199	2.38	No	No	0	5	3
244	R:R:E197	R:R:Y201	2.24	No	No	0	2	6
245	R:R:C121	R:R:C160	1.82	Yes	No	0	7	6
246	R:R:G224	R:R:T223	1.82	No	Yes	0	7	8
247	R:R:A181	R:R:C283	1.81	No	No	0	4	4
248	R:R:A212	R:R:S127	1.71	No	No	0	7	7
249	R:R:G158	R:R:L161	1.71	No	No	0	1	3
250	R:R:G273	R:R:L203	1.71	No	No	0	4	4
251	R:R:G214	R:R:L213	1.71	No	Yes	0	3	8
252	R:R:G214	R:R:L217	1.71	No	No	0	3	5
253	R:R:A253	R:R:V303	1.7	No	No	0	5	8
254	R:R:G276	R:R:N275	1.7	No	Yes	0	1	1
255	R:R:G276	R:R:N277	1.7	No	No	0	1	1
256	R:R:C283	R:R:T282	1.69	No	No	0	4	4
257	R:R:K139	R:R:P140	1.67	No	No	0	5	8
258	R:R:C114	R:R:I110	1.64	No	No	0	4	5
259	R:R:C256	R:R:I260	1.64	No	No	0	5	5
260	R:R:C261	R:R:I260	1.64	No	No	0	8	5
261	R:R:A70	R:R:I305	1.62	No	Yes	0	8	8
262	R:R:A49	R:R:K53	1.61	No	No	0	3	4
263	R:R:A221	R:R:M255	1.61	No	No	0	4	8
264	R:R:V34	R:R:V89	1.6	No	No	0	4	6
265	R:R:T38	R:R:V39	1.59	No	No	0	5	6
266	R:R:T268	R:R:T286	1.57	No	No	0	5	7
267	R:R:I41	R:R:S45	1.55	No	No	0	6	5
268	R:R:K63	R:R:S149	1.53	No	No	0	6	3
269	R:R:M154	R:R:S157	1.53	No	No	0	3	3
270	R:R:M155	R:R:V128	1.52	No	No	0	5	7
271	R:R:F79	R:R:G80	1.51	No	No	0	5	8
272	R:R:L161	R:R:V164	1.49	No	No	0	3	4
273	R:R:L211	R:R:V215	1.49	No	No	0	4	5
274	R:R:L227	R:R:V248	1.49	Yes	No	0	8	7
275	R:R:L252	R:R:V248	1.49	No	No	0	5	7
276	R:R:N275	R:R:S279	1.49	Yes	No	0	1	1
277	R:R:I305	R:R:I50	1.47	Yes	No	0	8	8
278	R:R:I48	R:R:M52	1.46	No	No	0	7	4
279	R:R:G173	R:R:Y201	1.45	No	No	0	7	6
280	R:R:I222	R:R:L218	1.43	No	No	0	4	3
281	R:R:K153	R:R:L68	1.41	No	No	0	5	6
282	R:R:K313	R:R:L312	1.41	No	No	0	4	7
283	R:R:A54	R:R:F58	1.39	No	No	0	7	4
284	R:R:E246	R:R:I249	1.37	No	No	0	7	6
285	R:R:F31	R:R:S29	1.32	No	No	0	4	7
286	R:R:F32	R:R:S29	1.32	No	No	0	4	7
287	R:R:F31	R:R:V30	1.31	No	Yes	0	4	6
288	R:R:F117	R:R:V164	1.31	No	No	0	7	4
289	R:R:I225	R:R:R229	1.25	No	No	0	3	4
290	R:R:F200	R:R:L204	1.22	No	No	0	5	4
291	R:R:E284	R:R:R27	1.16	No	No	0	1	2
292	R:R:H174	R:R:R175	1.13	No	No	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.20933	15	1	0
2	R:R:V30	4.7775	4	0	6
3	R:R:F36	5.3475	4	1	8
4	R:R:N44	5.6675	4	0	9
5	R:R:L67	3.664	5	0	8
6	R:R:D77	5.2	5	1	9
7	R:R:N84	5.836	5	1	6
8	R:R:Y92	6.7475	4	1	8
9	R:R:W98	7.56	6	5	5
10	R:R:F111	7.86	4	1	6
11	R:R:M115	7.5075	4	1	8
12	R:R:V116	4.04	4	1	8
13	R:R:C121	4.468	5	0	7
14	R:R:M129	5.625	4	0	9
15	R:R:R133	4.745	6	3	9
16	R:R:C134	3.4175	4	0	6
17	R:R:H143	5.532	5	2	8
18	R:R:I166	5.1925	4	0	6
19	R:R:Y177	7.538	5	1	7
20	R:R:T184	5.4425	4	1	9
21	R:R:W185	7.70286	7	1	8
22	R:R:F187	5.69167	6	1	8
23	R:R:Y188	5.31429	7	1	6
24	R:R:L202	3.465	4	0	6
25	R:R:L213	2.5625	4	0	8
26	R:R:N220	5.0725	4	6	9
27	R:R:T223	3.172	5	7	8
28	R:R:L227	3.5125	4	7	8
29	R:R:Q250	9.4475	4	3	8
30	R:R:I254	6.0625	4	3	8
31	R:R:W262	7.87143	7	1	9
32	R:R:F265	5.79	4	1	8
33	R:R:N275	4.5	5	4	1
34	R:R:L280	8.675	4	4	2
35	R:R:Q297	5.694	5	1	8
36	R:R:Y304	6.964	5	3	9
37	R:R:I305	2.9125	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S33	14.7351	5.84	Yes	No	0	0	7
2	R:R:S33	R:R:V30	13.5302	3.23	No	Yes	0	7	6
3	L:L:?1	R:R:Y92	15.5233	4.56	Yes	Yes	1	0	8
4	R:R:V30	R:R:Y92	15.4909	11.36	Yes	Yes	0	6	8
5	R:R:F31	R:R:V30	21.1485	1.31	No	Yes	0	4	6
6	R:R:F31	R:R:S29	18.5168	1.32	No	No	0	4	7
7	R:R:F32	R:R:S29	15.8801	1.32	No	No	0	4	7
8	R:R:F32	R:R:R291	13.2384	10.69	No	No	0	4	8
9	L:L:?1	R:R:F36	10.1751	3.16	Yes	Yes	1	0	8
10	L:L:?1	R:R:Q297	84.9107	4.31	Yes	Yes	1	0	8
11	R:R:D77	R:R:Q297	81.0542	3.92	Yes	Yes	1	9	8
12	R:R:D77	R:R:N44	10.1502	6.73	Yes	Yes	0	9	9
13	L:L:?1	R:R:W262	46.4029	3.69	Yes	Yes	1	0	9
14	R:R:N296	R:R:W262	57.5334	15.82	No	Yes	0	9	9
15	R:R:D300	R:R:N296	56.149	9.42	No	No	0	9	9
16	R:R:D300	R:R:Y304	100	3.45	No	Yes	0	9	9
17	R:R:M129	R:R:Y304	61.3525	8.38	Yes	Yes	0	9	9
18	R:R:F66	R:R:M129	29.6498	4.98	No	Yes	0	7	9
19	R:R:F66	R:R:L67	53.7418	3.65	No	Yes	0	7	8
20	R:R:L51	R:R:L67	30.1686	2.77	No	Yes	0	8	8
21	R:R:I305	R:R:L51	24.5136	5.71	Yes	No	0	8	8
22	R:R:I305	R:R:L306	12.5798	2.85	Yes	No	0	8	8
23	R:R:D300	R:R:D77	45.2729	3.99	No	Yes	0	9	9
24	R:R:D77	R:R:L73	44.9935	8.14	Yes	No	0	9	9
25	R:R:L73	R:R:Y304	44.7166	3.52	No	Yes	0	9	9
26	R:R:R133	R:R:Y304	74.0596	6.17	Yes	Yes	3	9	9
27	R:R:F66	R:R:R133	30.7349	5.34	No	Yes	0	7	9
28	R:R:L69	R:R:M129	34.8882	5.65	No	Yes	0	7	9
29	R:R:E132	R:R:L69	30.3283	5.3	No	No	0	9	7
30	R:R:E132	R:R:H143	22.1263	4.92	No	Yes	0	9	8
31	R:R:P122	R:R:T76	14.1214	3.5	No	No	0	9	8
32	R:R:C121	R:R:T76	13.1311	6.76	Yes	No	0	7	8
33	L:L:?1	R:R:N84	27.4371	5.34	Yes	Yes	1	0	6
34	R:R:F111	R:R:N84	15.8002	4.83	Yes	Yes	1	6	6
35	L:L:?1	R:R:M115	16.6958	10.99	Yes	Yes	1	0	8
36	R:R:F111	R:R:M115	17.9181	4.98	Yes	Yes	1	6	8
37	R:R:C186	R:R:F111	29.071	2.79	No	Yes	0	9	6
38	R:R:C186	R:R:W98	24.7481	3.92	No	Yes	0	9	5
39	L:L:?1	R:R:W185	74.9476	3.69	Yes	Yes	1	0	8
40	R:R:F187	R:R:W185	63.1336	7.02	Yes	Yes	1	8	8
41	R:R:F187	R:R:V116	15.1567	3.93	Yes	Yes	1	8	8
42	R:R:V116	R:R:Y177	12.1134	5.05	Yes	Yes	1	8	7
43	R:R:I113	R:R:Y177	18.8361	6.04	No	Yes	0	5	7
44	R:R:F187	R:R:Y188	50.5787	8.25	Yes	Yes	1	8	6
45	R:R:Y177	R:R:Y188	12.4751	6.95	Yes	Yes	1	7	6
46	R:R:L123	R:R:W262	11.3101	14.81	No	Yes	0	7	9
47	R:R:L251	R:R:R133	40.6755	3.64	No	Yes	0	8	9
48	R:R:L251	R:R:T223	33.621	2.95	No	Yes	0	8	8
49	R:R:C134	R:R:T223	20.4126	3.38	Yes	Yes	0	6	8
50	R:R:C134	R:R:C219	11.9936	3.64	Yes	No	0	6	7
51	R:R:C219	R:R:I131	10.2949	3.27	No	No	0	7	6
52	R:R:L123	R:R:L213	10.5268	2.77	No	Yes	0	7	8
53	R:R:I254	R:R:Y304	13.161	13.3	Yes	Yes	3	8	9
54	R:R:H143	R:R:I135	12.3254	3.98	Yes	No	2	8	5
55	R:R:F142	R:R:I135	10.5942	2.51	No	No	0	4	5
56	R:R:F187	R:R:F205	15.1866	5.36	Yes	No	1	8	8
57	R:R:F205	R:R:L120	14.6952	7.31	No	No	0	8	6
58	R:R:I166	R:R:L120	13.1461	2.85	Yes	No	0	6	6
59	R:R:L202	R:R:Y188	30.1113	3.52	Yes	Yes	0	6	6
60	R:R:D198	R:R:L202	13.1087	4.07	No	Yes	0	5	6
61	R:R:Q180	R:R:W185	11.4897	20.81	No	Yes	1	8	8
62	R:R:Q180	R:R:T190	11.572	11.34	No	No	0	8	7
63	R:R:E191	R:R:T190	10.4994	2.82	No	No	0	3	7
64	R:R:F265	R:R:M269	18.1501	7.46	Yes	No	0	8	7
65	R:R:Q250	R:R:R308	15.693	21.03	Yes	No	0	8	9
66	R:R:F288	R:R:R291	10.6341	4.28	No	No	0	4	8
67	R:R:I272	R:R:L202	12.8617	2.85	No	Yes	0	6	6
68	R:R:F187	R:R:M269	17.6187	3.73	Yes	No	0	8	7
69	R:R:F265	R:R:W262	18.3247	6.01	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S33	5.84	1	Yes	No	0	7	0	1
L:L:?1	R:R:F36	3.16	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:H81	12.5	1	Yes	No	0	8	0	1
L:L:?1	R:R:N84	5.34	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:G85	4.43	1	Yes	No	0	7	0	1
L:L:?1	R:R:A88	3.06	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y92	4.56	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:M115	10.99	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T184	7.64	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:W185	3.69	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W262	3.69	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F265	5.53	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L290	10.76	1	Yes	No	0	7	0	1
L:L:?1	R:R:T294	7.64	1	Yes	No	0	9	0	1
L:L:?1	R:R:Q297	4.31	1	Yes	Yes	0	8	0	1
R:R:S33	R:R:V30	3.23	0	No	Yes	7	6	1	2
R:R:V30	R:R:Y92	11.36	0	Yes	Yes	6	8	2	1
R:R:F36	R:R:T294	5.19	1	Yes	No	8	9	1	1
R:R:F36	R:R:W295	8.02	1	Yes	No	8	5	1	2
R:R:F36	R:R:I298	5.02	1	Yes	No	8	8	1	2
R:R:G85	R:R:M37	3.49	0	No	No	7	7	1	2
R:R:G40	R:R:H81	3.18	0	No	No	9	8	2	1
R:R:D77	R:R:P122	3.22	1	Yes	No	9	9	2	2
R:R:D77	R:R:Q297	3.92	1	Yes	Yes	9	8	2	1
R:R:H81	R:R:Q297	3.71	1	No	Yes	8	8	1	1
R:R:F111	R:R:N84	4.83	1	Yes	Yes	6	6	2	1
R:R:C114	R:R:N84	4.72	0	No	Yes	4	6	2	1
R:R:M115	R:R:N84	9.82	1	Yes	Yes	8	6	1	1
R:R:N84	R:R:S118	4.47	1	Yes	No	6	7	1	2
R:R:K96	R:R:Y92	3.58	1	No	Yes	5	8	2	1
R:R:T184	R:R:Y92	7.49	1	Yes	Yes	9	8	1	1
R:R:K96	R:R:T184	3	1	No	Yes	5	9	2	1
R:R:F111	R:R:M115	4.98	1	Yes	Yes	6	8	2	1
R:R:L290	R:R:M115	4.24	1	No	Yes	7	8	1	1
R:R:P122	R:R:Q297	11.05	1	No	Yes	9	8	2	1
R:R:L123	R:R:W262	14.81	0	No	Yes	7	9	2	1
R:R:Q180	R:R:W185	20.81	1	No	Yes	8	8	2	1
R:R:F187	R:R:Q180	5.86	1	Yes	No	8	8	2	2
R:R:S182	R:R:W185	4.94	0	No	Yes	8	8	2	1
R:R:T184	R:R:W185	3.64	1	Yes	Yes	9	8	1	1
R:R:F187	R:R:W185	7.02	1	Yes	Yes	8	8	2	1
R:R:L290	R:R:W185	11.39	1	No	Yes	7	8	1	1
R:R:F187	R:R:M269	3.73	1	Yes	No	8	7	2	2
R:R:F265	R:R:W262	6.01	1	Yes	Yes	8	9	1	1
R:R:A293	R:R:W262	6.48	0	No	Yes	8	9	2	1
R:R:N296	R:R:W262	15.82	0	No	Yes	9	9	2	1
R:R:Q297	R:R:W262	5.48	1	Yes	Yes	8	9	1	1
R:R:F265	R:R:M269	7.46	1	Yes	No	8	7	1	2
R:R:A289	R:R:F265	4.16	0	No	Yes	7	8	2	1
R:R:I298	R:R:W295	3.52	1	No	No	8	5	2	2
R:R:G119	R:R:W262	2.81	0	No	Yes	7	9	2	1
R:R:T286	R:R:W185	2.43	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IQ6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	262
Number of Links	292
Number of Hubs	37
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	53
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	85866
Length Of Smallest Path	3
Average Path Length	12.9178
Length of Longest Path	24
Minimum Path Strength	1.315
Average Path Strength	5.4994
Maximum Path Strength	17.195
Minimum Path Correlation	0.7
Average Path Correlation	0.906619
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	38.8444
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.103
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • prostanoid receptor activity • molecular transducer activity • prostaglandin F receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • icosanoid receptor activity • prostaglandin receptor activity • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • defense response • response to stress • inflammatory response • cellular response to prostaglandin D stimulus • response to prostaglandin D • multi-multicellular organism process • reproductive process • parturition • multi-organism reproductive process • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to estradiol
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7WT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7WT
Name	Latanoprost acid
Synonyms	7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]hept-5-enoic acid
Identifier
Formula	C23 H34 O5
Molecular Weight	390.513
SMILES
PubChem	6441636
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	5
Total Bonds	63
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43088
Sequence	>8IQ6_nogp_Chain_R R L S V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q K S K A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D K E W I R F D Q S N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K P I F H S T K I T S K H V K M M L S G V C L F A V F I A L L P I L G H R D Y K I Q A S R T W C F Y N T E D I K D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N G N H S L E T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A V L K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XJK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Cloprosetnol	-		2.63	2024-02-28	doi.org/10.1016/j.celrep.2024.113893
	8XJM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.85	2024-02-28	To be published
	8XJM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.85	2024-02-28	To be published
	8XJL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.77	2024-02-28	To be published
	8XJL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.77	2024-02-28	To be published
	8IQ6	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ6 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		3.4	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IQ4 (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Carboprost	-		2.7	2024-01-31	10.1038/s41467-023-43922-8
	8IUM	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUM (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Tafluprost acid	-		3.14	2023-07-12	10.1038/s41467-023-38411-x
	8IUL	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUL (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	Latanoprost	-		2.78	2023-07-12	10.1038/s41467-023-38411-x
	8IUK	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.67	2023-07-12	10.1038/s41467-023-38411-x
	8IUK (No Gprot)	A	Lipid	Prostanoid	FP-alpha	Homo sapiens	PGF2-α	-		2.67	2023-07-12	10.1038/s41467-023-38411-x

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