Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I54 6.036527
2R:R:N58 7.8025429
3R:R:L71 5.8975438
4R:R:H73 5.794537
5R:R:T75 7.00667636
6R:R:Y78 6.9075434
7R:R:F79 5.224508
8R:R:D87 7.7925429
9R:R:V90 4.744528
10R:R:F117 5.6325405
11R:R:K125 6.436526
12R:R:S126 4.5125406
13R:R:M129 3.9675407
14R:R:L132 4.1475408
15R:R:I135 4.515409
16R:R:Y149 7.24538
17R:R:V153 3.626537
18R:R:F173 5.5925106
19R:R:K182 11.8425403
20R:R:Y185 7.652557
21R:R:H186 6.618522
22R:R:W192 10.9775404
23R:R:T199 5.4225403
24R:R:F203 5.62333605
25R:R:T204 6.5175405
26R:R:L210 4.574135
27R:R:Y212 6.782525
28R:R:Y223 6.925119
29R:R:Y263 3.134507
30R:R:F274 5.592509
31R:R:W278 7.338528
32R:R:Y281 4.626526
33R:R:Y284 5.86857754
34R:R:E288 9.9375453
35R:R:N295 5.366553
36R:R:W304 7.5625404
37R:R:I307 5.658526
38R:R:N309 5429
39R:R:S310 6.426529
40R:R:P314 4.77525
41R:R:F324 12.6075408
42R:R:L331 3.96754156
43R:R:?493 10.6575444
44R:R:?494 16.4575447
45V:V:K10 7.385449
46V:V:S13 3.945408
47V:V:Y21 6.21167648
48V:V:R25 7.4375409
49V:V:D38 6.6875407
50V:V:V43 4.6725466
51V:V:Y47 9.7875465
52V:V:L48 7.644564
53V:V:T58 5.9225407
54V:V:L73 5.8554158
55V:V:F80 4.3454184
56V:V:L104 5.5375449
57V:V:K107 6.255449
58V:V:Y113 8.005403
59V:V:F115 5.02409
60V:V:F117 5.7875408
61V:V:P120 4.884187
62V:V:L123 5.36754186
63V:V:P131 2.404508
64V:V:Y144 6.788507
65V:V:K147 7.8025477
66V:V:V150 6.416565
67V:V:L166 4.7225408
68V:V:R169 5.7975409
69V:V:Y173 3.99504
70V:V:L203 6.5325418
71V:V:Y208 9.59516
72V:V:H210 8.54419
73V:V:H219 10.434235
74V:V:I233 5.1825415
75V:V:R236 7.334505
76V:V:Q237 7.528519
77V:V:Y238 7.40754244
78V:V:N245 4.045438
79V:V:V253 3.994519
80V:V:Y272 6.44667614
81V:V:L287 4.815407
82V:V:L305 5.8875405
83V:V:L315 4.565405
84V:V:I317 3.5125408
85V:V:Y321 8.836519
86V:V:V323 4.105417
87V:V:K326 5.4754257
88V:V:F349 6.53517
89V:V:T350 4.12254214
90V:V:L351 5.4175418
91V:V:M352 4.5165218
92V:V:H353 6.27418
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I307 R:R:K125 13.48628.72YesYes266
2R:R:C94 R:R:G91 11.14481.96NoNo076
3R:R:W278 R:R:Y281 17.50383.86YesYes286
4R:R:F274 R:R:W278 34.42047.02YesYes098
5R:R:F274 R:R:L132 67.54143.65YesYes098
6R:R:L132 R:R:M83 75.18424.24YesNo089
7R:R:C131 R:R:M83 75.39463.24NoNo089
8R:R:C131 R:R:F79 75.6084.19NoYes088
9R:R:F79 R:R:L158 85.87713.65YesNo087
10R:R:L158 R:R:Y78 86.83393.52NoYes074
11R:R:K125 R:R:W278 12.07265.8YesYes268
12R:R:K125 R:R:N309 10.56416.99YesYes269
13R:R:F274 R:R:N309 20.8258.46YesYes099
14R:R:P155 R:R:Y78 93.21684.17NoYes034
15R:R:P155 V:V:K250 93.97718.36NoNo035
16V:V:K250 V:V:R236 94.13036.19NoYes055
17V:V:P252 V:V:R236 99.54892.88NoYes045
18V:V:P252 V:V:V251 99.77623.53NoNo046
19V:V:L287 V:V:V251 1004.47YesNo076
20R:R:F274 R:R:Y275 13.03296.19YesNo095
21R:R:I270 R:R:L132 11.15054.28NoYes088
22R:R:I270 R:R:N313 10.79444.25NoNo089
23R:R:G184 R:R:Y281 10.95532.9NoYes026
24R:R:F285 R:R:G184 10.58713.01NoNo052
25V:V:L287 V:V:Q237 70.95493.99YesYes079
26V:V:Q237 V:V:V319 41.68337.16YesNo098
27V:V:A301 V:V:V319 41.39535.09NoNo098
28V:V:A301 V:V:V127 41.25133.39NoNo098
29V:V:I317 V:V:V127 41.10953.07YesNo088
30V:V:F61 V:V:I317 40.28196.28NoYes098
31V:V:F61 V:V:L79 40.14496.09NoNo098
32V:V:L79 V:V:V59 40.01475.96NoNo088
33V:V:V59 V:V:Y144 38.360511.36NoYes087
34V:V:K170 V:V:Y144 13.27888.36NoYes097
35V:V:Q237 V:V:Y321 21.933619.16YesYes199
36V:V:L351 V:V:Y321 19.22937.03YesYes189
37V:V:H210 V:V:L351 25.56187.71YesYes198
38V:V:H210 V:V:S302 21.30125.58YesNo099
39V:V:M352 V:V:S302 20.84493.07YesNo089
40V:V:L305 V:V:M352 18.07777.07YesYes058
41V:V:L305 V:V:Q172 16.45463.99YesNo059
42V:V:D29 V:V:Q172 16.16456.53NoNo099
43V:V:D29 V:V:K170 15.065817.97NoNo099
44V:V:L287 V:V:L300 31.46754.15YesNo079
45V:V:L300 V:V:Y321 21.26224.69NoYes199
46R:R:?491 V:V:R25 10.68169.98NoYes069
47V:V:L166 V:V:R25 13.18567.29YesYes089
48V:V:L166 V:V:V146 23.09734.47YesNo086
49V:V:I168 V:V:V146 23.27694.61NoNo086
50V:V:I168 V:V:Y144 23.89584.84NoYes087
51V:V:D38 V:V:Q101 10.261813.05YesNo079
52V:V:D38 V:V:G39 11.6415.03YesNo078
53V:V:F115 V:V:G39 11.91434.52YesNo098
54V:V:F115 V:V:F117 21.54545.36YesYes098
55V:V:F117 V:V:L57 22.01957.31YesNo087
56V:V:L57 V:V:Y144 22.21774.69NoYes077
57V:V:F115 V:V:V55 12.04886.55YesNo098
58V:V:V41 V:V:V55 11.5693.21NoNo058
59V:V:S86 V:V:V41 21.73933.23NoNo065
60V:V:S86 V:V:Y113 21.23743.82NoYes063
61V:V:V43 V:V:Y113 10.00245.05YesYes063
62V:V:L166 V:V:V20 11.02772.98YesNo086
63V:V:V20 V:V:V41 10.78793.21NoNo065
64V:V:F87 V:V:Y113 10.536313.41NoYes043
65V:V:F349 V:V:Y321 23.66648.25YesYes179
66V:V:F349 V:V:V323 28.05923.93YesYes177
67V:V:Q237 V:V:V253 11.50094.3YesYes199
68V:V:A254 V:V:V253 19.60661.7NoYes079
69V:V:A254 V:V:V235 19.17371.7NoNo078
70V:V:L274 V:V:V235 18.96214.47NoNo058
71V:V:E256 V:V:L274 18.4326.63NoNo045
72V:V:E256 V:V:Y272 17.89517.86NoYes144
73V:V:K270 V:V:Y272 38.36529.55NoYes084
74V:V:F268 V:V:K270 37.56896.2NoNo058
75V:V:F268 V:V:V220 35.97365.24NoNo056
76V:V:V220 V:V:V262 29.46674.81NoNo067
77V:V:V228 V:V:V262 23.81343.21NoNo087
78V:V:V228 V:V:V329 23.08653.21NoNo086
79V:V:F190 V:V:V329 19.832.62NoNo096
80V:V:F190 V:V:K226 17.36033.72NoNo2298
81V:V:K226 V:V:T224 16.55966.01NoNo089
82V:V:N223 V:V:T224 14.91924.39NoNo069
83V:V:K195 V:V:N223 14.09772.8NoNo076
84V:V:K195 V:V:P196 13.27541.67NoNo076
85V:V:P196 V:V:T187 10.80318.74NoNo065
86V:V:L300 V:V:V253 10.2965.96NoYes199
87V:V:V216 V:V:V323 24.97934.81NoYes177
88V:V:I233 V:V:V216 24.65444.61YesNo157
89V:V:I233 V:V:Y272 23.64646.04YesYes154
90R:R:M129 R:R:S126 12.15023.07YesYes076
91R:R:M129 R:R:Y275 12.63214.79YesNo075
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9IJS
Class A
SubFamily Orphan
Type Orphan
SubType GPR52
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Arrestin2
PDB Resolution 3.64
Date 2025-09-03
D.O.I. doi.org/10.1038/s41422-025-01165-w
Net Summary
Imin 2.88
Number of Linked Nodes 604
Number of Links 696
Number of Hubs 92
Number of Links mediated by Hubs 334
Number of Communities 26
Number of Nodes involved in Communities 136
Number of Links involved in Communities 173
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 357227
Length Of Smallest Path 3
Average Path Length 25.4883
Length of Longest Path 55
Minimum Path Strength 1.335
Average Path Strength 5.6832
Maximum Path Strength 24.52
Minimum Path Correlation 0.7
Average Path Correlation 0.966361
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 44.5118
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.3082
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeSEP
PDB ResiduesR:R:?488 R:R:?493 R:R:?494 R:R:?495
Environment DetailsOpen EMBL-EBI Page
CodeSEP
NameDexfosfoserine
SynonymsPHOSPHONOSERINE
Identifier
FormulaC3 H8 N O6 P
Molecular Weight185.072
SMILES
PubChem57689797
Formal Charge0
Total Atoms19
Total Chiral Atoms1
Total Bonds18
Total Aromatic Bonds0

CodeTPO
PDB ResiduesR:R:?490 R:R:?491
Environment DetailsOpen EMBL-EBI Page
CodeTPO
NamePHOSPHOTHREONINE
SynonymsPHOSPHONOTHREONINE
Identifier
FormulaC4 H10 N O6 P
Molecular Weight199.099
SMILES
PubChem139055008
Formal Charge0
Total Atoms22
Total Chiral Atoms2
Total Bonds21
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9Y2T5
Sequence
>9IJS_Chain_R
FETVVIVLL TFLIIAGNL TVIFVFHCA PLLHHYTTS YFIQTMAYA 
DLFVGVSCL VPTLSLLHY STGVHESLT CQVFGYIIS VLKSVSMWC 
LACISVDRY LAITKPLSY NQLVTPCRL RICIILIWI YSCLIFLPS 
FFGWGKPGY HGDIFEWCA TSWLTSAYF TGFIVCLLY APAAFVVCF 
TYFHIFKIC RQHTRRYAM VLFRITSVF YMLWLPYII YFLLESSRV 
LDNPTLSFL TTWLAISNS FCNPVIYSL SNSVFRLGL RRLSETE?A 
??A???LAK D


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainV
ProteinArrestin
UniProtP49407
Sequence
>9IJS_Chain_V
TRVFKKASP NGKLTVYLG KRDFVDHID LVDPVDGVV LVDPEYLKE 
RRVYVTLTV AFRYGREDL DVLGLTFRK DLFVANVQS FPPAPEDKK 
PLTRLQERL IKKLGEHAY PFTFEIPPN LPSSVTLQP GPEDTGKAL 
GVDYEVKAF VAENLEEKI HKRNSVRLV IRKVQYAPE RPGPQPTAE 
TTRQFLMSD KPLHLEASL DKEIYYHGE PISVNVHVT NNTNKTVKK 
IKISVRQYA DIVLFNTAQ YKVPVAMEE ADDTVAPSS TFSKVYTLT 
PFLANNREK RGLALDGKL KHEDTNLAS STLLREGAN REILGIIVS 
YKVKVKLVV SRGGLLGDL ASSDVAVEL PFTLMHPKP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LI0AOrphanOrphanGPR52Homo sapiens-C17-2.22020-02-26doi.org/10.1038/s41586-020-2019-0
6LI1AOrphanOrphanGPR52Homo sapiens---2.92020-02-26doi.org/10.1038/s41586-020-2019-0
6LI2AOrphanOrphanGPR52Homo sapiens---2.82020-02-26doi.org/10.1038/s41586-020-2019-0
6LI3AOrphanOrphanGPR52Homo sapiens--Gs/β1/γ23.322020-02-26doi.org/10.1038/s41586-020-2019-0
6LI3 (No Gprot) AOrphanOrphanGPR52Homo sapiens--3.322020-02-26doi.org/10.1038/s41586-020-2019-0
8HMPAOrphanOrphanGPR52Homo sapiens-C17Gs/β1/γ22.772023-06-21doi.org/10.1002/mco2.260
8HMP (No Gprot) AOrphanOrphanGPR52Homo sapiens-C172.772023-06-21doi.org/10.1002/mco2.260
9IJRAOrphanOrphanGPR52Homo sapiens-C17Arrestin23.862025-09-03doi.org/10.1038/s41422-025-01165-w
9IJSAOrphanOrphanGPR52Homo sapiens--Arrestin23.642025-09-03doi.org/10.1038/s41422-025-01165-w




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9IJS.zip



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