psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?5	L:L:D4	8.53	Yes	No	3	0	0
2	L:L:D4	L:L:F6	5.97	No	Yes	3	0	0
3	L:L:?5	L:L:F6	7.66	Yes	Yes	3	0	0
4	L:L:?5	L:L:C10	7.13	Yes	No	3	0	0
5	L:L:?5	R:R:Y283	4.21	Yes	Yes	3	0	4
6	L:L:?5	R:R:N297	3.7	Yes	No	3	0	4
7	L:L:F6	R:R:L200	6.09	Yes	No	0	0	4
8	L:L:F6	R:R:P201	10.11	Yes	No	0	0	5
9	L:L:F6	R:R:Y283	6.19	Yes	Yes	3	0	4
10	L:L:K8	L:L:W7	11.6	Yes	Yes	0	0	0
11	L:L:W7	R:R:F127	4.01	Yes	Yes	0	0	5
12	L:L:W7	R:R:F131	14.03	Yes	Yes	0	0	4
13	L:L:W7	R:R:L212	5.69	Yes	No	0	0	5
14	L:L:W7	R:R:W277	6.56	Yes	Yes	0	0	4
15	L:L:W7	R:R:L280	5.69	Yes	No	0	0	4
16	L:L:K8	R:R:Y100	5.97	Yes	Yes	4	0	7
17	L:L:K8	R:R:I107	4.36	Yes	Yes	4	0	6
18	L:L:K8	R:R:D130	6.91	Yes	Yes	0	0	7
19	L:L:K8	R:R:T301	10.51	Yes	No	0	0	5
20	L:L:K8	R:R:Y305	4.78	Yes	Yes	4	0	7
21	L:L:Y9	R:R:I107	6.04	Yes	Yes	0	0	6
22	L:L:Y9	R:R:L126	11.72	Yes	No	0	0	5
23	L:L:Y9	R:R:F127	5.16	Yes	Yes	0	0	5
24	L:L:Y9	R:R:D130	5.75	Yes	Yes	0	0	7
25	L:L:C10	R:R:N297	4.72	No	No	3	0	4
26	L:L:V11	R:R:S197	4.85	No	No	0	0	4
27	L:L:V11	R:R:L198	10.43	No	No	0	0	4
28	R:R:D47	R:R:L45	6.79	No	No	0	5	3
29	R:R:D47	R:R:L48	10.86	No	No	0	5	4
30	R:R:L48	R:R:T51	4.42	No	No	0	4	4
31	R:R:T113	R:R:T51	4.71	No	No	0	5	4
32	R:R:I54	R:R:Y298	4.84	Yes	Yes	0	3	4
33	R:R:I54	R:R:L299	5.71	Yes	No	0	3	5
34	R:R:L57	R:R:M61	4.24	No	No	0	5	7
35	R:R:I104	R:R:L58	5.71	Yes	No	0	8	6
36	R:R:C302	R:R:L58	9.52	No	No	0	5	6
37	R:R:C302	R:R:M61	3.24	No	No	0	5	7
38	R:R:G306	R:R:M61	3.49	No	No	0	6	7
39	R:R:G62	R:R:I104	3.53	No	Yes	0	6	8
40	R:R:C309	R:R:G65	3.92	No	No	0	7	8
41	R:R:L101	R:R:V66	2.98	Yes	No	0	6	6
42	R:R:D97	R:R:N69	18.85	No	No	2	9	9
43	R:R:L98	R:R:N69	6.87	No	No	0	7	9
44	R:R:N69	R:R:P312	6.52	No	No	2	9	9
45	R:R:P312	R:R:T72	3.5	No	Yes	2	9	9
46	R:R:T316	R:R:T72	12.56	No	Yes	2	7	9
47	R:R:A94	R:R:L73	3.15	No	No	0	9	7
48	R:R:L80	R:R:V75	2.98	No	No	0	5	8
49	R:R:V75	R:R:Y322	5.05	No	No	0	8	8
50	R:R:T76	R:R:Y87	8.74	No	Yes	0	7	7
51	R:R:T316	R:R:T76	3.14	No	No	2	7	7
52	R:R:C77	R:R:Y87	6.72	No	Yes	0	3	7
53	R:R:L80	R:R:S79	3	No	No	0	5	5
54	R:R:H325	R:R:S79	15.34	No	No	0	3	5
55	R:R:R81	R:R:Y87	23.66	No	Yes	0	6	7
56	R:R:N321	R:R:V83	4.43	Yes	No	0	6	6
57	R:R:M86	R:R:Y89	7.18	No	Yes	7	7	7
58	R:R:M144	R:R:M86	8.66	No	No	0	9	7
59	R:R:E147	R:R:M86	4.06	Yes	No	7	8	7
60	R:R:V88	R:R:Y87	3.79	No	Yes	0	6	7
61	R:R:V91	R:R:Y87	18.93	No	Yes	0	6	7
62	R:R:K167	R:R:V88	3.04	No	No	0	3	6
63	R:R:V143	R:R:Y89	7.57	No	Yes	0	7	7
64	R:R:E147	R:R:Y89	4.49	Yes	Yes	7	8	7
65	R:R:R166	R:R:Y89	10.29	Yes	Yes	0	8	7
66	R:R:L169	R:R:Y89	7.03	No	Yes	0	5	7
67	R:R:A170	R:R:N92	4.69	No	No	0	8	9
68	R:R:N92	R:R:W174	4.52	No	Yes	0	9	9
69	R:R:L93	R:R:S137	3	Yes	No	0	9	9
70	R:R:L141	R:R:L93	5.54	Yes	Yes	1	9	9
71	R:R:L93	R:R:N311	9.61	Yes	Yes	1	9	9
72	R:R:L93	R:R:Y315	3.52	Yes	Yes	1	9	9
73	R:R:A96	R:R:S137	3.42	No	No	0	8	9
74	R:R:D97	R:R:P312	3.22	No	No	2	9	9
75	R:R:L99	R:R:T133	4.42	No	No	0	6	8
76	R:R:T133	R:R:Y100	6.24	No	Yes	0	8	7
77	R:R:M134	R:R:Y100	9.58	Yes	Yes	0	7	7
78	R:R:T304	R:R:Y100	6.24	No	Yes	0	8	7
79	R:R:Y100	R:R:Y305	8.94	Yes	Yes	4	7	7
80	R:R:S308	R:R:Y100	5.09	No	Yes	0	9	7
81	R:R:L101	R:R:Y305	3.52	Yes	Yes	0	6	7
82	R:R:L101	R:R:S308	3	Yes	No	0	6	9
83	R:R:C309	R:R:L101	3.17	No	Yes	0	7	6
84	R:R:D130	R:R:S103	8.83	Yes	No	0	7	7
85	R:R:S103	R:R:Y305	5.09	No	Yes	0	7	7
86	R:R:I104	R:R:P105	3.39	Yes	No	0	8	8
87	R:R:I104	R:R:Y305	13.3	Yes	Yes	0	8	7
88	R:R:F106	R:R:F118	9.65	No	Yes	0	6	7
89	R:R:F106	R:R:L126	15.83	No	No	0	6	5
90	R:R:I107	R:R:Y298	6.04	Yes	Yes	0	6	4
91	R:R:I107	R:R:Y305	4.84	Yes	Yes	4	6	7
92	R:R:E115	R:R:Y111	10.1	No	No	0	5	4
93	R:R:T113	R:R:Y298	17.48	No	Yes	0	5	4
94	R:R:E115	R:R:K114	10.8	No	No	0	5	4
95	R:R:K114	R:R:R294	6.19	No	No	0	4	4
96	R:R:F118	R:R:W116	7.02	Yes	No	0	7	8
97	R:R:F118	R:R:H117	9.05	Yes	Yes	0	7	2
98	R:R:C123	R:R:H117	4.42	No	Yes	0	9	2
99	R:R:F118	R:R:G122	3.01	Yes	No	0	7	6
100	R:R:D120	R:R:R124	7.15	No	No	0	3	7
101	R:R:D120	R:R:L190	16.29	No	No	0	3	5
102	R:R:G122	R:R:V121	3.68	No	No	0	6	1
103	R:R:C123	R:R:F127	4.19	No	Yes	0	9	5
104	R:R:C123	R:R:C199	7.28	No	No	0	9	9
105	R:R:M188	R:R:R124	6.2	Yes	No	0	5	7
106	R:R:F127	R:R:M188	9.95	Yes	Yes	0	5	5
107	R:R:G128	R:R:M185	5.24	No	No	0	5	4
108	R:R:D130	R:R:L129	4.07	Yes	No	0	7	5
109	R:R:F131	R:R:H135	3.39	Yes	Yes	0	4	7
110	R:R:F131	R:R:T181	3.89	Yes	Yes	0	4	7
111	R:R:F131	R:R:V184	7.87	Yes	No	0	4	5
112	R:R:L132	R:R:W174	5.69	No	Yes	0	5	9
113	R:R:A177	R:R:L132	3.15	No	No	0	8	5
114	R:R:L132	R:R:T181	7.37	No	Yes	0	5	7
115	R:R:H135	R:R:M134	3.94	Yes	Yes	0	7	7
116	R:R:I138	R:R:M134	4.37	No	Yes	0	8	7
117	R:R:M134	R:R:W277	6.98	Yes	Yes	0	7	4
118	R:R:H135	R:R:L180	9	Yes	No	5	7	4
119	R:R:H135	R:R:L215	5.14	Yes	Yes	5	7	5
120	R:R:H135	R:R:S219	9.76	Yes	No	5	7	6
121	R:R:A136	R:R:W174	7.78	No	Yes	0	7	9
122	R:R:I138	R:R:P223	3.39	No	No	0	8	9
123	R:R:F274	R:R:I138	6.28	No	No	0	6	8
124	R:R:F139	R:R:T173	3.89	No	No	0	6	7
125	R:R:F139	R:R:L176	10.96	No	No	0	6	4
126	R:R:T140	R:R:T173	4.71	No	No	0	7	7
127	R:R:L141	R:R:N311	9.61	Yes	Yes	1	9	9
128	R:R:L141	R:R:Y315	7.03	Yes	Yes	1	9	9
129	R:R:P223	R:R:T142	5.25	No	No	0	9	7
130	R:R:I227	R:R:T142	6.08	Yes	No	0	8	7
131	R:R:M144	R:R:Y315	11.97	No	Yes	0	9	9
132	R:R:I227	R:R:S145	9.29	Yes	No	1	8	9
133	R:R:S145	R:R:Y231	13.99	No	Yes	1	9	9
134	R:R:L230	R:R:S146	3	No	No	0	7	5
135	R:R:E147	R:R:Y165	8.98	Yes	Yes	0	8	4
136	R:R:R148	R:R:Y231	9.26	No	Yes	1	9	9
137	R:R:R148	R:R:Y315	8.23	No	Yes	1	9	9
138	R:R:L153	R:R:Y149	11.72	No	No	0	7	8
139	R:R:L230	R:R:Y149	10.55	No	No	0	7	8
140	R:R:R233	R:R:Y149	15.43	No	No	0	4	8
141	R:R:A151	R:R:T158	3.36	No	Yes	0	8	5
142	R:R:L153	R:R:V152	2.98	No	No	0	7	8
143	R:R:L234	R:R:V152	8.94	No	No	0	8	8
144	R:R:A237	R:R:L153	4.73	No	No	0	5	7
145	R:R:D157	R:R:R154	9.53	No	No	0	4	6
146	R:R:R161	R:R:T158	5.17	No	Yes	0	6	5
147	R:R:R161	R:R:Y165	7.2	No	Yes	0	6	4
148	R:R:R166	R:R:Y165	14.4	Yes	Yes	0	8	4
149	R:R:L169	R:R:Y165	4.69	No	Yes	0	5	4
150	R:R:G172	R:R:L175	5.13	No	No	0	4	4
151	R:R:L180	R:R:L215	5.54	No	Yes	5	4	5
152	R:R:L182	R:R:P183	3.28	No	No	0	4	7
153	R:R:P183	R:R:Y211	12.52	No	No	0	7	6
154	R:R:M188	R:R:V184	3.04	Yes	No	0	5	5
155	R:R:V184	R:R:Y211	3.79	No	No	0	5	6
156	R:R:M188	R:R:P201	6.71	Yes	No	0	5	5
157	R:R:R189	R:R:W203	7	No	No	0	4	5
158	R:R:R192	R:R:R193	11.73	No	No	0	1	1
159	R:R:L200	R:R:R192	3.64	No	No	0	4	1
160	R:R:G194	R:R:P195	4.06	No	No	0	1	4
161	R:R:L198	R:R:P195	6.57	No	No	0	4	4
162	R:R:G204	R:R:P205	4.06	No	No	0	5	3
163	R:R:H208	R:R:L212	11.57	No	No	0	4	5
164	R:R:H284	R:R:R209	19.18	No	No	0	3	3
165	R:R:L215	R:R:Y211	8.21	Yes	No	0	5	6
166	R:R:L215	R:R:S219	3	Yes	No	5	5	6
167	R:R:F216	R:R:I220	10.05	No	No	6	5	9
168	R:R:F216	R:R:W277	8.02	No	Yes	6	5	4
169	R:R:F274	R:R:I220	5.02	No	No	0	6	9
170	R:R:I220	R:R:W277	10.57	No	Yes	6	9	4
171	R:R:G222	R:R:P223	4.06	No	No	0	6	9
172	R:R:C270	R:R:G224	3.92	No	No	0	9	6
173	R:R:I227	R:R:Y231	3.63	Yes	Yes	1	8	9
174	R:R:C270	R:R:I227	6.55	No	Yes	0	9	8
175	R:R:G228	R:R:L266	5.13	No	No	0	5	6
176	R:R:L265	R:R:Y231	4.69	Yes	Yes	1	5	9
177	R:R:Y231	R:R:Y315	2.98	Yes	Yes	1	9	9
178	R:R:A235	R:R:L259	4.73	No	No	0	5	7
179	R:R:Q242	R:R:Y238	3.38	No	No	0	4	8
180	R:R:L259	R:R:Y238	8.21	No	No	0	7	8
181	R:R:L259	R:R:R239	4.86	No	No	0	7	4
182	R:R:F267	R:R:I263	3.77	No	No	0	9	8
183	R:R:L314	R:R:V264	2.98	Yes	No	0	8	8
184	R:R:L265	R:R:L314	4.15	Yes	Yes	1	5	8
185	R:R:L265	R:R:Y315	12.89	Yes	Yes	1	5	9
186	R:R:P273	R:R:W268	18.92	No	No	1	9	6
187	R:R:N307	R:R:W268	3.39	No	No	1	9	6
188	R:R:A310	R:R:W268	3.89	No	No	0	6	6
189	R:R:F271	R:R:W275	3.01	Yes	No	0	9	7
190	R:R:L272	R:R:W275	6.83	No	No	0	6	7
191	R:R:N307	R:R:P273	3.26	No	No	1	9	9
192	R:R:F274	R:R:T304	3.89	No	No	0	6	8
193	R:R:Q278	R:R:W275	8.76	No	No	0	5	7
194	R:R:L276	R:R:L280	6.92	No	No	0	5	4
195	R:R:L276	R:R:T300	7.37	No	No	0	5	6
196	R:R:L279	R:R:V296	2.98	No	No	0	6	5
197	R:R:L280	R:R:Y283	3.52	No	Yes	0	4	4
198	R:R:A286	R:R:Q282	4.55	No	No	0	3	4
199	R:R:A293	R:R:L288	6.3	No	No	0	4	1
200	R:R:P290	R:R:R291	4.32	No	No	0	3	2
201	R:R:C309	R:R:G306	3.92	No	No	0	7	6
202	R:R:N307	R:R:N311	6.81	No	Yes	1	9	9
203	R:R:N311	R:R:Y315	5.81	Yes	Yes	1	9	9
204	R:R:F313	R:R:L317	6.09	No	No	0	6	7
205	R:R:R320	R:R:R323	6.4	No	No	0	5	8
206	R:R:L214	R:R:T218	2.95	No	No	0	4	4
207	R:R:L288	R:R:T292	2.95	No	No	0	1	3
208	R:R:D97	R:R:S308	2.94	No	No	0	9	9
209	R:R:N92	R:R:T140	2.92	No	No	0	9	7
210	R:R:N321	R:R:T319	2.92	Yes	No	0	6	8
211	R:R:P162	R:R:R161	2.88	No	No	0	6	6
212	R:R:I295	R:R:L299	2.85	No	No	0	1	5
213	L:L:C10	R:R:R294	2.79	No	No	0	0	4
214	R:R:H117	R:R:S197	2.79	Yes	No	0	2	4
215	R:R:C270	R:R:F271	2.79	No	Yes	0	9	9
216	R:R:L102	R:R:L99	2.77	No	No	0	5	6
217	R:R:A109	R:R:F118	2.77	No	Yes	0	3	7
218	R:R:A150	R:R:R154	2.77	No	No	0	4	6
219	R:R:L171	R:R:L175	2.77	No	No	0	4	4
220	R:R:L182	R:R:L186	2.77	No	No	0	4	3
221	R:R:A202	R:R:R206	2.77	No	No	0	2	1
222	R:R:A221	R:R:F216	2.77	No	No	0	4	5
223	R:R:L80	R:R:N321	2.75	No	Yes	0	5	6
224	R:R:L156	R:R:Q160	2.66	No	No	0	5	4
225	R:R:R166	R:R:S85	2.64	Yes	No	0	8	6
226	R:R:F313	R:R:V64	2.62	No	No	0	6	6
227	R:R:V67	R:R:Y71	2.52	No	No	0	4	6
228	R:R:T110	R:R:Y298	2.5	No	Yes	0	4	4
229	R:R:F271	R:R:L266	2.44	Yes	No	0	9	6
230	R:R:L95	R:R:W174	2.28	No	Yes	0	6	9
231	R:R:R189	R:R:R192	2.13	No	No	0	4	1
232	R:R:R206	R:R:R209	2.13	No	No	0	1	3
233	R:R:R236	R:R:R240	2.13	No	No	0	4	4
234	R:R:R209	R:R:Y283	2.06	No	Yes	0	3	4
235	R:R:A286	R:R:P287	1.87	No	No	0	3	6
236	R:R:A289	R:R:P290	1.87	No	No	0	1	3
237	R:R:G55	R:R:V108	1.84	No	No	0	5	7
238	R:R:G65	R:R:V64	1.84	No	No	0	8	6
239	R:R:G68	R:R:V67	1.84	No	No	0	8	4
240	R:R:G52	R:R:T51	1.82	No	No	0	4	4
241	R:R:G128	R:R:T181	1.82	No	Yes	0	5	7
242	R:R:G55	R:R:I54	1.76	No	Yes	0	5	3
243	R:R:C199	R:R:V191	1.71	No	No	0	9	1
244	R:R:A94	R:R:T72	1.68	No	Yes	0	9	9
245	R:R:A150	R:R:T158	1.68	No	Yes	0	4	5
246	R:R:A217	R:R:T218	1.68	No	No	0	4	4
247	R:R:A289	R:R:T292	1.68	No	No	0	1	3
248	R:R:L156	R:R:P155	1.64	No	No	0	5	7
249	R:R:L303	R:R:P273	1.64	No	No	0	8	9
250	R:R:A50	R:R:I295	1.62	No	No	0	3	1
251	R:R:V63	R:R:V67	1.6	No	No	0	5	4
252	R:R:V74	R:R:V75	1.6	No	No	0	4	8
253	R:R:V260	R:R:V264	1.6	No	No	0	7	8
254	R:R:T53	R:R:V49	1.59	No	No	0	5	2
255	R:R:T72	R:R:V90	1.59	Yes	No	2	9	8
256	R:R:T76	R:R:V90	1.59	No	No	2	7	8
257	R:R:T316	R:R:V90	1.59	No	No	2	7	8
258	R:R:G119	R:R:H117	1.59	No	Yes	0	7	2
259	R:R:T158	R:R:V159	1.59	Yes	No	0	5	5
260	R:R:T292	R:R:V296	1.59	No	No	0	3	5
261	R:R:T300	R:R:V296	1.59	No	No	0	6	5
262	R:R:A269	R:R:L141	1.58	No	Yes	0	6	9
263	R:R:A269	R:R:L265	1.58	No	Yes	0	6	5
264	R:R:T53	R:R:T56	1.57	No	No	0	5	6
265	R:R:A84	R:R:N321	1.56	No	Yes	0	8	6
266	R:R:I54	R:R:T53	1.52	Yes	No	0	3	5
267	R:R:F313	R:R:G68	1.51	No	No	0	6	8
268	R:R:L226	R:R:T142	1.47	No	No	0	6	7
269	R:R:L178	R:R:T181	1.47	No	Yes	0	3	7
270	R:R:E147	R:R:S146	1.44	Yes	No	0	8	5
271	R:R:P155	R:R:R154	1.44	No	No	0	7	6
272	R:R:L261	R:R:L314	1.38	No	Yes	1	4	8
273	R:R:L261	R:R:L318	1.38	No	No	1	4	7
274	R:R:L314	R:R:L318	1.38	Yes	No	1	8	7
275	R:R:H284	R:R:T213	1.37	No	No	0	3	4
276	R:R:E46	R:R:L45	1.33	No	No	0	2	3
277	R:R:L279	R:R:Q282	1.33	No	No	0	6	4
278	R:R:A187	R:R:W203	1.3	No	No	0	4	5
279	R:R:K163	R:R:R166	1.24	No	Yes	0	4	8
280	R:R:F271	R:R:L225	1.22	Yes	No	0	9	3
281	R:R:L317	R:R:Y322	1.17	No	No	0	7	8
282	R:R:R236	R:R:R239	1.07	No	No	0	4	4
283	R:R:R258	R:R:Y238	1.03	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?5	6.246	5	3	0
2	L:L:F6	7.204	5	3	0
3	L:L:W7	7.93	6	0	0
4	L:L:K8	7.355	6	4	0
5	L:L:Y9	7.1675	4	0	0
6	R:R:I54	3.4575	4	0	3
7	R:R:T72	4.8325	4	2	9
8	R:R:Y87	12.368	5	0	7
9	R:R:Y89	7.312	5	7	7
10	R:R:L93	5.4175	4	1	9
11	R:R:Y100	7.01	6	4	7
12	R:R:L101	3.1675	4	0	6
13	R:R:I104	6.4825	4	0	8
14	R:R:I107	5.32	4	4	6
15	R:R:H117	4.4625	4	0	2
16	R:R:F118	6.3	5	0	7
17	R:R:F127	5.8275	4	0	5
18	R:R:D130	6.39	4	0	7
19	R:R:F131	7.295	4	0	4
20	R:R:M134	6.2175	4	0	7
21	R:R:H135	6.246	5	5	7
22	R:R:L141	5.94	4	1	9
23	R:R:E147	4.7425	4	7	8
24	R:R:T158	2.95	4	0	5
25	R:R:Y165	8.8175	4	0	4
26	R:R:R166	7.1425	4	0	8
27	R:R:W174	5.0675	4	0	9
28	R:R:T181	3.6375	4	0	7
29	R:R:M188	6.475	4	0	5
30	R:R:L215	5.4725	4	5	5
31	R:R:I227	6.3875	4	1	8
32	R:R:Y231	6.91	5	1	9
33	R:R:L265	5.8275	4	1	5
34	R:R:F271	2.365	4	0	9
35	R:R:W277	8.0325	4	6	4
36	R:R:Y283	3.995	4	3	4
37	R:R:Y298	7.715	4	0	4
38	R:R:Y305	6.745	6	4	7
39	R:R:N311	7.96	4	1	9
40	R:R:L314	2.4725	4	1	8
41	R:R:Y315	7.49	7	1	9
42	R:R:N321	2.915	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F6	R:R:L200	11.1864	6.09	Yes	No	0	0	4
2	L:L:?5	R:R:Y283	11.2727	4.21	Yes	Yes	3	0	4
3	R:R:L280	R:R:Y283	29.8944	3.52	No	Yes	0	4	4
4	L:L:W7	R:R:L280	46.9229	5.69	Yes	No	0	0	4
5	R:R:F127	R:R:M188	11.6046	9.95	Yes	Yes	0	5	5
6	L:L:W7	R:R:W277	31.2819	6.56	Yes	Yes	0	0	4
7	L:L:K8	L:L:W7	42.8268	11.6	Yes	Yes	0	0	0
8	L:L:Y9	R:R:F127	10.3432	5.16	Yes	Yes	0	0	5
9	L:L:Y9	R:R:L126	12.2286	11.72	Yes	No	0	0	5
10	L:L:W7	R:R:F127	25.2274	4.01	Yes	Yes	0	0	5
11	R:R:C123	R:R:F127	23.4084	4.19	No	Yes	0	9	5
12	R:R:C123	R:R:H117	18.5554	4.42	No	Yes	0	9	2
13	L:L:K8	R:R:I107	24.1718	4.36	Yes	Yes	4	0	6
14	R:R:I107	R:R:Y298	43.6102	6.04	Yes	Yes	0	6	4
15	R:R:T113	R:R:Y298	17.3339	17.48	No	Yes	0	5	4
16	R:R:T113	R:R:T51	15.1696	4.71	No	No	0	5	4
17	R:R:L48	R:R:T51	10.164	4.42	No	No	0	4	4
18	R:R:I54	R:R:Y298	22.5785	4.84	Yes	Yes	0	3	4
19	L:L:K8	R:R:Y305	18.2035	4.78	Yes	Yes	4	0	7
20	R:R:L101	R:R:Y305	40.3505	3.52	Yes	Yes	0	6	7
21	R:R:C309	R:R:L101	48.4498	3.17	No	Yes	0	7	6
22	R:R:I104	R:R:Y305	12.2154	13.3	Yes	Yes	0	8	7
23	R:R:C309	R:R:G65	40.2642	3.92	No	No	0	7	8
24	L:L:K8	R:R:Y100	35.0661	5.97	Yes	Yes	4	0	7
25	R:R:S308	R:R:Y100	53.3161	5.09	No	Yes	0	9	7
26	R:R:D97	R:R:S308	47.1951	2.94	No	No	0	9	9
27	R:R:D97	R:R:P312	41.114	3.22	No	No	2	9	9
28	R:R:P312	R:R:T72	39.4145	3.5	No	Yes	2	9	9
29	R:R:T316	R:R:T72	16.7165	12.56	No	Yes	2	7	9
30	R:R:G65	R:R:V64	38.1398	1.84	No	No	0	8	6
31	R:R:F313	R:R:V64	36.0021	2.62	No	No	0	6	6
32	R:R:F313	R:R:L317	25.1145	6.09	No	No	0	6	7
33	R:R:L317	R:R:Y322	22.8972	1.17	No	No	0	7	8
34	R:R:V75	R:R:Y322	20.6665	5.05	No	No	0	8	8
35	R:R:L80	R:R:V75	16.1654	2.98	No	No	0	5	8
36	R:R:T316	R:R:T76	14.6452	3.14	No	No	2	7	7
37	R:R:T72	R:R:V90	16.7165	1.59	Yes	No	2	9	8
38	R:R:T76	R:R:V90	14.6452	1.59	No	No	2	7	8
39	R:R:T76	R:R:Y87	25.088	8.74	No	Yes	0	7	7
40	R:R:M134	R:R:W277	30.8106	6.98	Yes	Yes	0	7	4
41	R:R:I138	R:R:M134	99.1702	4.37	No	Yes	0	8	7
42	R:R:I138	R:R:P223	100	3.39	No	No	0	8	9
43	R:R:P223	R:R:T142	97.6499	5.25	No	No	0	9	7
44	R:R:I227	R:R:T142	95.2466	6.08	Yes	No	0	8	7
45	R:R:I227	R:R:Y231	80.7542	3.63	Yes	Yes	1	8	9
46	R:R:Y231	R:R:Y315	66.4144	2.98	Yes	Yes	1	9	9
47	R:R:M144	R:R:Y315	51.6232	11.97	No	Yes	0	9	9
48	R:R:M144	R:R:M86	49.9768	8.66	No	No	0	9	7
49	R:R:M86	R:R:Y89	10.6353	7.18	No	Yes	7	7	7
50	R:R:E147	R:R:M86	37.8411	4.06	Yes	No	7	8	7
51	L:L:W7	R:R:F131	20.7462	14.03	Yes	Yes	0	0	4
52	R:R:F131	R:R:T181	26.6813	3.89	Yes	Yes	0	4	7
53	R:R:L132	R:R:T181	19.8566	7.37	No	Yes	0	5	7
54	R:R:L132	R:R:W174	16.3646	5.69	No	Yes	0	5	9
55	R:R:N92	R:R:W174	11.027	4.52	No	Yes	0	9	9
56	R:R:N311	R:R:Y315	11.6245	5.81	Yes	Yes	1	9	9
57	R:R:F131	R:R:H135	15.6675	3.39	Yes	Yes	0	4	7
58	R:R:E147	R:R:S146	15.6941	1.44	Yes	No	0	8	5
59	R:R:L230	R:R:S146	13.7489	3	No	No	0	7	5
60	R:R:E147	R:R:Y165	22.7312	8.98	Yes	Yes	0	8	4
61	R:R:L230	R:R:Y149	11.7905	10.55	No	No	0	7	8
62	R:R:R161	R:R:Y165	21.4366	7.2	No	Yes	0	6	4
63	R:R:R161	R:R:T158	17.8583	5.17	No	Yes	0	6	5
64	R:R:A150	R:R:T158	12.0228	1.68	No	Yes	0	4	5
65	R:R:A150	R:R:R154	10.0511	2.77	No	No	0	4	6
66	R:R:C270	R:R:I227	17.5596	6.55	No	Yes	0	9	8
67	R:R:C270	R:R:F271	13.7489	2.79	No	Yes	0	9	9
68	R:R:L265	R:R:Y231	11.7241	4.69	Yes	Yes	1	5	9
69	R:R:L276	R:R:L280	19.757	6.92	No	No	0	5	4
70	R:R:L276	R:R:T300	18.3961	7.37	No	No	0	5	6
71	R:R:T300	R:R:V296	16.9223	1.59	No	No	0	6	5
72	L:L:F6	R:R:Y283	10.9474	6.19	Yes	Yes	3	0	4
73	L:L:Y9	R:R:I107	16.5837	6.04	Yes	Yes	0	0	6
74	R:R:I107	R:R:Y305	28.5335	4.84	Yes	Yes	4	6	7
75	R:R:H135	R:R:M134	22.3262	3.94	Yes	Yes	0	7	7
76	R:R:M134	R:R:Y100	69.9197	9.58	Yes	Yes	0	7	7
77	R:R:Y100	R:R:Y305	34.8204	8.94	Yes	Yes	4	7	7
78	R:R:L101	R:R:S308	22.8706	3	Yes	No	0	6	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?5	R:R:Y283	4.21	3	Yes	Yes	0	4	0	1
L:L:?5	R:R:N297	3.7	3	Yes	No	0	4	0	1
L:L:F6	R:R:L200	6.09	3	Yes	No	0	4	0	1
L:L:F6	R:R:P201	10.11	3	Yes	No	0	5	0	1
L:L:F6	R:R:Y283	6.19	3	Yes	Yes	0	4	0	1
L:L:W7	R:R:F127	4.01	0	Yes	Yes	0	5	0	1
L:L:W7	R:R:F131	14.03	0	Yes	Yes	0	4	0	1
L:L:W7	R:R:L212	5.69	0	Yes	No	0	5	0	1
L:L:W7	R:R:W277	6.56	0	Yes	Yes	0	4	0	1
L:L:W7	R:R:L280	5.69	0	Yes	No	0	4	0	1
L:L:K8	R:R:Y100	5.97	4	Yes	Yes	0	7	0	1
L:L:K8	R:R:I107	4.36	4	Yes	Yes	0	6	0	1
L:L:K8	R:R:D130	6.91	4	Yes	Yes	0	7	0	1
L:L:K8	R:R:T301	10.51	4	Yes	No	0	5	0	1
L:L:K8	R:R:Y305	4.78	4	Yes	Yes	0	7	0	1
L:L:Y9	R:R:I107	6.04	0	Yes	Yes	0	6	0	1
L:L:Y9	R:R:L126	11.72	0	Yes	No	0	5	0	1
L:L:Y9	R:R:F127	5.16	0	Yes	Yes	0	5	0	1
L:L:Y9	R:R:D130	5.75	0	Yes	Yes	0	7	0	1
L:L:C10	R:R:N297	4.72	3	No	No	0	4	0	1
L:L:V11	R:R:S197	4.85	0	No	No	0	4	0	1
L:L:V11	R:R:L198	10.43	0	No	No	0	4	0	1
R:R:T133	R:R:Y100	6.24	0	No	Yes	8	7	2	1
R:R:M134	R:R:Y100	9.58	0	Yes	Yes	7	7	2	1
R:R:T304	R:R:Y100	6.24	0	No	Yes	8	7	2	1
R:R:Y100	R:R:Y305	8.94	4	Yes	Yes	7	7	1	1
R:R:S308	R:R:Y100	5.09	0	No	Yes	9	7	2	1
R:R:L101	R:R:Y305	3.52	0	Yes	Yes	6	7	2	1
R:R:L101	R:R:S308	3	0	Yes	No	6	9	2	2
R:R:D130	R:R:S103	8.83	0	Yes	No	7	7	1	2
R:R:S103	R:R:Y305	5.09	0	No	Yes	7	7	2	1
R:R:I104	R:R:Y305	13.3	0	Yes	Yes	8	7	2	1
R:R:F106	R:R:L126	15.83	0	No	No	6	5	2	1
R:R:I107	R:R:Y298	6.04	4	Yes	Yes	6	4	1	2
R:R:I107	R:R:Y305	4.84	4	Yes	Yes	6	7	1	1
R:R:K114	R:R:R294	6.19	0	No	No	4	4	2	1
R:R:C123	R:R:H117	4.42	0	No	Yes	9	2	2	2
R:R:C123	R:R:F127	4.19	0	No	Yes	9	5	2	1
R:R:F127	R:R:M188	9.95	0	Yes	Yes	5	5	1	2
R:R:D130	R:R:L129	4.07	0	Yes	No	7	5	1	2
R:R:F131	R:R:H135	3.39	0	Yes	Yes	4	7	1	2
R:R:F131	R:R:T181	3.89	0	Yes	Yes	4	7	1	2
R:R:F131	R:R:V184	7.87	0	Yes	No	4	5	1	2
R:R:H135	R:R:M134	3.94	5	Yes	Yes	7	7	2	2
R:R:M134	R:R:W277	6.98	0	Yes	Yes	7	4	2	1
R:R:M188	R:R:V184	3.04	0	Yes	No	5	5	2	2
R:R:M188	R:R:P201	6.71	0	Yes	No	5	5	2	1
R:R:L200	R:R:R192	3.64	0	No	No	4	1	1	2
R:R:L198	R:R:P195	6.57	0	No	No	4	4	1	2
R:R:H208	R:R:L212	11.57	0	No	No	4	5	2	1
R:R:F216	R:R:I220	10.05	6	No	No	5	9	2	2
R:R:F216	R:R:W277	8.02	6	No	Yes	5	4	2	1
R:R:I220	R:R:W277	10.57	6	No	Yes	9	4	2	1
R:R:L276	R:R:L280	6.92	0	No	No	5	4	2	1
R:R:L280	R:R:Y283	3.52	0	No	Yes	4	4	1	1
L:L:C10	R:R:R294	2.79	3	No	No	0	4	0	1
R:R:H117	R:R:S197	2.79	0	Yes	No	2	4	2	1
R:R:R209	R:R:Y283	2.06	0	No	Yes	3	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JFK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	254
Number of Links	283
Number of Hubs	42
Number of Links mediated by Hubs	143
Number of Communities	7
Number of Nodes involved in Communities	42
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	37520
Length Of Smallest Path	3
Average Path Length	12.8956
Length of Longest Path	31
Minimum Path Strength	1.54
Average Path Strength	5.56482
Maximum Path Strength	21.295
Minimum Path Correlation	0.7
Average Path Correlation	0.925586
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	52.1399
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.7171
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	LE1
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	LE1
Name	3-sulfanyl-L-valine
Synonyms	L-LE1ICILLAMINE; L-Penicillamine
Identifier
Formula	C5 H11 N O2 S
Molecular Weight	149.211
SMILES
PubChem	6926436
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	1
Total Bonds	19
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	(Pen5)-Urotensin II
UniProt	O95399
Sequence	>9JFK_nogp_Chain_L D ?F W K Y C V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q9UKP6
Sequence	>9JFK_nogp_Chain_R L E D L V A T G T I G T L L S A M G V V G V V G N A Y T L V V T C R S L R A V A S M Y V Y V V N L A L A D L L Y L L S I P F I V A T Y V T K E W H F G D V G C R V L F G L D F L T M H A S I F T L T V M S S E R Y A A V L R P L D T V Q R P K G Y R K L L A L G T W L L A L L L T L P V M L A M R L V R R G P K S L C L P A W G P R A H R A Y L T L L F A T S I A G P G L L I G L L Y A R L A R A Y R R S Q R A L R L V L G I V L L F W A C F L P F W L W Q L L A Q Y H Q A P L A P R T A R I V N Y L T T C L T Y G N S C A N P F L Y T L L T R N Y R D H L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7UTZ	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	DPPC	Gs/β1/γ2	2.4	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	7UTZ (No Gprot)	A	Protein	Glycoprotein Hormone	TSH	Homo sapiens	TSH	DPPC		2.4	2022-08-03	doi.org/10.1038/s41586-022-05159-1
	8GUT	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-	Gi1/β1/γ2	2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8GUT (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	LEI-102	-		2.98	2023-05-10	doi.org/10.1038/s41467-023-37112-9
	8YUT	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-	Gs/β1/γ2	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUT (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	9K0K	A	Nucleotide	P2Y	P2Y₄	Homo sapiens	UTP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.14	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K0K (No Gprot)	A	Nucleotide	P2Y	P2Y₄	Homo sapiens	UTP	-		3.14	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9UT8	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.41	2025-07-16	doi.org/10.1038/s41586-025-09302-6
	9UTA	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	-	-	-	3.77	2025-07-16	doi.org/10.1038/s41586-025-09302-6
	9UTB	C	Sensory	Taste1	TAS1R2; TAS1R3	Homo sapiens	Sucralose	-	-	3.59	2025-07-16	doi.org/10.1038/s41586-025-09302-6
	9KUT	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Go/β1/γ2	3.29	2025-11-26	10.1101/2025.05.26.656101
	9KUT (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3.29	2025-11-26	10.1101/2025.05.26.656101
	9JFK	A	Peptide	Urotensin	UT	Homo sapiens	(Pen5)-Urotensin II	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.23	2025-12-03	10.1016/j.jbc.2025.110794
	9JFK (No Gprot)	A	Peptide	Urotensin	UT	Homo sapiens	(Pen5)-Urotensin II	-		3.23	2025-12-03	10.1016/j.jbc.2025.110794

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