psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D98	8.76	Yes	Yes	1	0	5
2	L:L:?1	R:R:V99	12.36	Yes	No	0	0	4
3	L:L:?1	R:R:C102	8.78	Yes	No	1	0	7
4	L:L:?1	R:R:T103	8.15	Yes	No	1	0	6
5	L:L:?1	R:R:D186	15.01	Yes	Yes	1	0	4
6	L:L:?1	R:R:T190	5.44	Yes	Yes	1	0	5
7	L:L:?1	R:R:Y250	18.37	Yes	Yes	0	0	6
8	L:L:?1	R:R:F251	8.98	Yes	Yes	1	0	7
9	L:L:?1	R:R:F254	6.74	Yes	No	0	0	4
10	R:R:L80	R:R:T22	8.84	No	No	0	4	5
11	R:R:A76	R:R:L25	4.73	No	Yes	0	6	7
12	R:R:L25	R:R:L80	4.15	Yes	No	0	7	4
13	R:R:L25	R:R:W275	7.97	Yes	No	0	7	5
14	R:R:I29	R:R:L72	4.28	No	No	0	6	7
15	R:R:G35	R:R:P285	4.06	No	No	0	8	9
16	R:R:D64	R:R:N36	6.73	Yes	Yes	0	9	9
17	R:R:L65	R:R:N36	5.49	Yes	Yes	0	7	9
18	R:R:N36	R:R:P285	6.52	Yes	No	0	9	9
19	R:R:L65	R:R:V37	4.47	Yes	No	0	7	4
20	R:R:V38	R:R:Y299	6.31	No	Yes	0	7	6
21	R:R:A42	R:R:Y299	5.34	No	Yes	0	8	6
22	R:R:V43	R:R:V58	4.81	No	No	0	7	5
23	R:R:N46	R:R:Q301	14.52	No	Yes	0	5	4
24	R:R:R48	R:R:T297	5.17	No	No	5	6	4
25	R:R:Q301	R:R:R48	10.51	Yes	No	5	4	6
26	R:R:F295	R:R:L49	3.65	Yes	No	0	8	7
27	R:R:N51	R:R:T53	5.85	No	No	0	7	8
28	R:R:L52	R:R:P132	9.85	No	No	0	6	2
29	R:R:L52	R:R:V135	4.47	No	No	0	6	7
30	R:R:N54	R:R:T53	7.31	No	No	0	8	8
31	R:R:F295	R:R:N54	10.87	Yes	No	0	8	8
32	R:R:C55	R:R:F56	4.19	No	Yes	0	4	8
33	R:R:F56	R:R:M111	9.95	Yes	No	0	8	6
34	R:R:F56	R:R:I112	3.77	Yes	No	0	8	9
35	R:R:D115	R:R:F56	7.17	No	Yes	0	8	8
36	R:R:F56	R:R:V135	7.87	Yes	No	0	8	7
37	R:R:F56	R:R:L139	4.87	Yes	No	0	8	7
38	R:R:N108	R:R:S59	10.43	No	No	0	8	9
39	R:R:L109	R:R:L60	5.54	No	No	2	8	9
40	R:R:L60	R:R:N284	12.36	No	Yes	2	9	9
41	R:R:T63	R:R:W143	3.64	No	No	0	8	9
42	R:R:D64	R:R:S105	5.89	Yes	No	0	9	9
43	R:R:D64	R:R:S281	11.78	Yes	No	0	9	9
44	R:R:D64	R:R:N284	6.73	Yes	Yes	0	9	9
45	R:R:L65	R:R:L69	4.15	Yes	No	4	7	5
46	R:R:L66	R:R:L70	5.54	No	No	0	7	5
47	R:R:L101	R:R:L66	4.15	No	No	0	7	7
48	R:R:L67	R:R:V71	4.47	No	No	0	8	6
49	R:R:L101	R:R:L67	9.69	No	No	0	7	8
50	R:R:D98	R:R:V71	4.38	Yes	No	0	5	6
51	R:R:L72	R:R:Y278	7.03	No	Yes	0	7	6
52	R:R:F74	R:R:W84	4.01	No	Yes	3	5	8
53	R:R:F74	R:R:F86	7.5	No	Yes	3	5	6
54	R:R:F74	R:R:F90	7.5	No	No	3	5	6
55	R:R:S75	R:R:Y94	6.36	No	No	0	6	5
56	R:R:S75	R:R:Y278	7.63	No	Yes	0	6	6
57	R:R:W84	R:R:Y78	7.72	Yes	No	0	8	4
58	R:R:A271	R:R:Q79	4.55	No	No	0	4	3
59	R:R:Q79	R:R:W275	4.38	No	No	0	3	5
60	R:R:F86	R:R:W84	20.04	Yes	Yes	3	6	8
61	R:R:F90	R:R:W84	5.01	No	Yes	3	6	8
62	R:R:C91	R:R:W84	6.53	Yes	Yes	3	9	8
63	R:R:W84	R:R:Y94	14.47	Yes	No	0	8	5
64	R:R:C174	R:R:W84	18.28	No	Yes	3	9	8
65	R:R:F86	R:R:F90	6.43	Yes	No	3	6	6
66	R:R:C174	R:R:C91	7.28	No	Yes	3	9	9
67	R:R:F151	R:R:S96	11.89	Yes	No	0	3	4
68	R:R:I154	R:R:S96	4.64	No	No	0	4	4
69	R:R:C102	R:R:D98	4.67	No	Yes	1	7	5
70	R:R:D98	R:R:Y278	11.49	Yes	Yes	0	5	6
71	R:R:M100	R:R:W143	4.65	Yes	No	0	5	9
72	R:R:M100	R:R:S150	7.67	Yes	No	6	5	7
73	R:R:F151	R:R:M100	6.22	Yes	Yes	6	3	5
74	R:R:C102	R:R:W247	5.22	No	Yes	1	7	8
75	R:R:S146	R:R:T103	6.4	No	No	0	8	6
76	R:R:T103	R:R:T190	4.71	No	Yes	1	6	5
77	R:R:A104	R:R:W143	6.48	No	No	0	7	9
78	R:R:I106	R:R:W247	16.44	No	Yes	0	7	8
79	R:R:I142	R:R:L107	11.42	No	No	0	6	5
80	R:R:I142	R:R:N108	4.25	No	No	0	6	8
81	R:R:L109	R:R:N284	8.24	No	Yes	2	8	9
82	R:R:L109	R:R:Y288	7.03	No	Yes	2	8	9
83	R:R:F110	R:R:L114	9.74	Yes	No	0	7	6
84	R:R:F110	R:R:P194	5.78	Yes	No	0	7	8
85	R:R:F110	R:R:I197	8.79	Yes	No	0	7	6
86	R:R:F110	R:R:M198	4.98	Yes	Yes	0	7	8
87	R:R:M111	R:R:S138	7.67	No	No	0	6	6
88	R:R:I142	R:R:M111	4.37	No	No	0	6	6
89	R:R:I112	R:R:R116	3.76	No	No	2	9	9
90	R:R:I112	R:R:Y288	4.84	No	Yes	2	9	9
91	R:R:M198	R:R:S113	6.13	Yes	No	0	8	9
92	R:R:S113	R:R:Y202	12.72	No	Yes	0	9	9
93	R:R:D115	R:R:Y126	10.34	No	Yes	0	8	7
94	R:R:R116	R:R:Y288	8.23	No	Yes	2	9	9
95	R:R:M121	R:R:Y117	15.57	No	Yes	0	7	7
96	R:R:T201	R:R:Y117	8.74	No	Yes	0	7	7
97	R:R:R204	R:R:Y117	8.23	No	Yes	0	3	7
98	R:R:I205	R:R:Y117	3.63	No	Yes	0	8	7
99	R:R:A119	R:R:Y126	6.67	No	Yes	0	8	7
100	R:R:M121	R:R:V208	4.56	No	No	0	7	5
101	R:R:D122	R:R:R125	16.68	No	No	0	6	5
102	R:R:L129	R:R:R125	3.64	No	No	0	4	5
103	R:R:V130	R:R:Y126	13.88	No	Yes	0	7	7
104	R:R:P132	R:R:T131	5.25	No	No	0	2	8
105	R:R:R134	R:R:T131	5.17	No	No	0	5	8
106	R:R:D186	R:R:L149	5.43	Yes	No	0	4	5
107	R:R:F151	R:R:S150	6.61	Yes	No	6	3	7
108	R:R:F151	R:R:H155	4.53	Yes	No	0	3	4
109	R:R:L152	R:R:W158	6.83	No	No	0	6	4
110	R:R:S153	R:R:W158	7.41	No	No	0	5	4
111	R:R:S153	R:R:Y182	3.82	No	Yes	0	5	5
112	R:R:I154	R:R:N159	8.5	No	No	0	4	5
113	R:R:L156	R:R:W158	13.67	No	No	0	3	4
114	R:R:N159	R:R:Y182	8.14	No	Yes	0	5	5
115	R:R:E180	R:R:R161	6.98	No	No	0	2	1
116	R:R:D262	R:R:R161	4.76	No	No	0	1	1
117	R:R:N162	R:R:T164	7.31	No	No	0	4	2
118	R:R:K173	R:R:N168	16.79	No	No	0	4	2
119	R:R:H169	R:R:T170	8.21	No	No	0	3	5
120	R:R:K175	R:R:R257	8.66	No	Yes	0	4	4
121	R:R:F254	R:R:V178	15.73	No	No	0	4	1
122	R:R:R257	R:R:V178	7.85	Yes	No	0	4	1
123	R:R:G258	R:R:V178	3.68	No	No	0	4	1
124	R:R:E180	R:R:L259	3.98	No	No	0	2	5
125	R:R:D186	R:R:Y182	8.05	Yes	Yes	0	4	5
126	R:R:L184	R:R:L259	5.54	No	No	0	4	5
127	R:R:D186	R:R:T190	4.34	Yes	Yes	1	4	5
128	R:R:F251	R:R:T190	3.89	Yes	Yes	1	7	5
129	R:R:F191	R:R:Y192	9.28	Yes	No	0	8	4
130	R:R:F191	R:R:L195	3.65	Yes	No	1	8	7
131	R:R:F191	R:R:F243	7.5	Yes	No	1	8	9
132	R:R:F191	R:R:W247	5.01	Yes	Yes	1	8	8
133	R:R:F191	R:R:F248	6.43	Yes	No	0	8	5
134	R:R:F191	R:R:F251	15	Yes	Yes	1	8	7
135	R:R:T252	R:R:Y192	3.75	No	No	0	6	4
136	R:R:F243	R:R:L195	3.65	No	No	1	9	7
137	R:R:M198	R:R:M240	4.33	Yes	No	0	8	8
138	R:R:F243	R:R:M198	7.46	No	Yes	0	9	8
139	R:R:I200	R:R:R204	5.01	No	No	0	5	3
140	R:R:V239	R:R:Y202	3.79	No	Yes	0	8	9
141	R:R:M240	R:R:Y202	5.99	No	Yes	0	8	9
142	R:R:K207	R:R:Y203	9.55	No	No	0	4	3
143	R:R:F206	R:R:R210	5.34	No	No	0	5	5
144	R:R:F206	R:R:T233	5.19	No	No	0	5	6
145	R:R:F206	R:R:L236	3.65	No	No	0	5	7
146	R:R:Q212	R:R:R215	7.01	No	No	0	6	4
147	R:R:A213	R:R:E229	4.53	No	No	0	4	7
148	R:R:I216	R:R:I227	7.36	No	No	8	5	5
149	R:R:A225	R:R:N217	6.25	No	No	0	4	3
150	R:R:I227	R:R:N217	5.66	No	No	0	5	3
151	R:R:E229	R:R:N217	5.26	No	No	0	7	3
152	R:R:K223	R:R:S220	7.65	No	No	0	4	6
153	R:R:S221	R:R:W222	6.18	No	No	0	5	4
154	R:R:K223	R:R:T226	4.5	No	No	0	4	3
155	R:R:K231	R:R:R228	16.09	No	No	0	8	6
156	R:R:C246	R:R:N280	9.45	No	No	0	9	9
157	R:R:W247	R:R:Y250	3.86	Yes	Yes	0	8	6
158	R:R:F251	R:R:W247	9.02	Yes	Yes	1	7	8
159	R:R:G277	R:R:W247	8.44	No	Yes	0	7	8
160	R:R:N280	R:R:W247	6.78	No	Yes	0	9	8
161	R:R:F248	R:R:P249	4.33	No	No	0	5	9
162	R:R:F248	R:R:T252	7.78	No	No	0	5	6
163	R:R:V273	R:R:Y250	3.79	No	Yes	0	5	6
164	R:R:L274	R:R:Y250	5.86	No	Yes	0	5	6
165	R:R:R260	R:R:Y256	9.26	No	No	0	4	4
166	R:R:A264	R:R:Y256	4	No	No	0	2	4
167	R:R:I265	R:R:Y256	3.63	Yes	No	0	1	4
168	R:R:D262	R:R:R257	4.76	No	Yes	0	1	4
169	R:R:I265	R:R:R257	5.01	Yes	Yes	7	1	4
170	R:R:E270	R:R:R257	5.82	No	Yes	7	4	4
171	R:R:E270	R:R:I265	9.56	No	Yes	7	4	1
172	R:R:E267	R:R:N266	6.57	No	No	0	4	4
173	R:R:N266	R:R:V268	4.43	No	No	0	4	1
174	R:R:L274	R:R:Y278	14.07	No	Yes	0	5	6
175	R:R:W275	R:R:Y278	9.65	No	Yes	0	5	6
176	R:R:N280	R:R:N284	6.81	No	Yes	0	9	9
177	R:R:N284	R:R:Y288	4.65	Yes	Yes	2	9	9
178	R:R:A289	R:R:F295	5.55	No	Yes	0	7	8
179	R:R:D294	R:R:N292	8.08	No	No	0	6	8
180	R:R:F295	R:R:N292	4.83	Yes	No	0	8	8
181	R:R:R293	R:R:R296	7.46	No	No	0	5	8
182	R:R:F295	R:R:Y299	4.13	Yes	Yes	0	8	6
183	R:R:Q301	R:R:T297	4.25	Yes	No	5	4	4
184	R:R:G298	R:R:Q301	4.93	No	Yes	0	5	4
185	R:R:F303	R:R:L302	7.31	No	No	0	6	5
186	R:R:L236	R:R:Y202	3.52	No	Yes	0	7	9
187	R:R:L287	R:R:Y288	3.52	Yes	Yes	2	8	9
188	R:R:N179	R:R:Y182	3.49	No	Yes	0	4	5
189	R:R:A61	R:R:V39	3.39	No	No	0	9	9
190	R:R:A290	R:R:I286	3.25	No	No	0	6	7
191	R:R:D122	R:R:P123	3.22	No	No	0	6	8
192	R:R:S113	R:R:T201	3.2	No	No	0	9	7
193	R:R:T95	R:R:V176	3.17	No	No	0	5	5
194	R:R:T131	R:R:V133	3.17	No	No	0	8	4
195	R:R:T190	R:R:V189	3.17	Yes	No	0	5	5
196	R:R:C199	R:R:L195	3.17	No	No	0	5	7
197	R:R:T233	R:R:V234	3.17	No	No	0	6	7
198	R:R:A61	R:R:N36	3.13	No	Yes	0	9	9
199	R:R:I31	R:R:V27	3.07	No	No	0	5	5
200	R:R:I137	R:R:V133	3.07	No	No	0	4	4
201	R:R:I272	R:R:V268	3.07	No	No	0	5	1
202	R:R:K83	R:R:S172	3.06	No	No	0	5	4
203	R:R:M121	R:R:V120	3.04	No	No	0	7	8
204	R:R:F254	R:R:G183	3.01	No	No	0	4	5
205	R:R:K88	R:R:T171	3	No	No	0	3	1
206	R:R:L65	R:R:V33	2.98	Yes	No	4	7	6
207	R:R:L69	R:R:V33	2.98	No	No	4	5	6
208	R:R:L41	R:R:V37	2.98	No	No	0	4	4
209	R:R:L269	R:R:V268	2.98	No	No	0	5	1
210	R:R:N179	R:R:V181	2.96	No	No	0	4	4
211	R:R:L28	R:R:T32	2.95	No	No	0	7	8
212	R:R:N36	R:R:T32	2.92	Yes	No	0	9	8
213	R:R:I147	R:R:M100	2.92	No	Yes	0	4	5
214	R:R:I244	R:R:M240	2.92	No	No	0	6	8
215	R:R:G187	R:R:Y192	2.9	No	No	0	5	4
216	R:R:Q177	R:R:S160	2.89	No	No	0	3	4
217	R:R:K173	R:R:K175	2.87	No	No	0	4	4
218	R:R:I21	R:R:L25	2.85	No	Yes	0	4	7
219	R:R:I93	R:R:L97	2.85	No	No	0	5	5
220	R:R:I145	R:R:L107	2.85	No	No	0	5	5
221	R:R:I137	R:R:L141	2.85	No	No	0	4	4
222	R:R:I145	R:R:L149	2.85	No	No	0	5	5
223	R:R:I200	R:R:L196	2.85	No	No	0	5	4
224	R:R:I272	R:R:L276	2.85	No	No	0	5	7
225	R:R:P127	R:R:Y126	2.78	No	Yes	0	4	7
226	R:R:L302	R:R:L45	2.77	No	No	9	5	5
227	R:R:L188	R:R:L193	2.77	No	No	0	5	6
228	R:R:L283	R:R:L287	2.77	No	Yes	2	6	8
229	R:R:C118	R:R:Y126	2.69	No	Yes	0	5	7
230	R:R:F86	R:R:S85	2.64	Yes	No	0	6	3
231	R:R:E163	R:R:N162	2.63	No	No	0	1	4
232	R:R:F295	R:R:V43	2.62	Yes	No	0	8	7
233	R:R:H218	R:R:K214	2.62	No	No	0	3	4
234	R:R:E267	R:R:E270	2.54	No	No	0	4	4
235	R:R:V39	R:R:Y299	2.52	No	Yes	0	9	6
236	R:R:F295	R:R:I57	2.51	Yes	No	0	8	8
237	R:R:F86	R:R:I77	2.51	Yes	No	0	6	4
238	R:R:K207	R:R:R210	2.48	No	No	0	4	5
239	R:R:L49	R:R:R48	2.43	No	No	0	7	6
240	R:R:L129	R:R:R134	2.43	No	No	0	4	5
241	R:R:D211	R:R:R215	2.38	No	No	0	4	4
242	R:R:K223	R:R:W222	2.32	No	No	0	4	4
243	R:R:A34	R:R:G35	1.95	No	No	0	5	8
244	R:R:G157	R:R:S160	1.86	No	No	0	4	4
245	R:R:G167	R:R:S165	1.86	No	No	0	1	3
246	R:R:G68	R:R:V33	1.84	No	No	0	7	6
247	R:R:G183	R:R:V255	1.84	No	No	0	5	5
248	R:R:G187	R:R:V255	1.84	No	No	0	5	5
249	R:R:G87	R:R:T171	1.82	No	No	0	8	1
250	R:R:A61	R:R:C40	1.81	No	No	0	9	7
251	R:R:G241	R:R:I245	1.76	No	No	0	5	6
252	R:R:G157	R:R:N159	1.7	No	No	0	4	5
253	R:R:C91	R:R:T95	1.69	Yes	No	3	9	5
254	R:R:C174	R:R:T95	1.69	No	No	3	9	5
255	R:R:A282	R:R:T32	1.68	No	No	0	7	8
256	R:R:D262	R:R:G261	1.68	No	No	0	1	4
257	R:R:D263	R:R:G261	1.68	No	No	0	1	4
258	R:R:C17	R:R:I21	1.64	No	No	0	3	4
259	R:R:C40	R:R:I62	1.64	No	No	0	7	6
260	R:R:L72	R:R:P73	1.64	No	No	0	7	8
261	R:R:L193	R:R:P194	1.64	No	No	0	6	8
262	R:R:A282	R:R:I31	1.62	No	No	0	7	5
263	R:R:A253	R:R:I265	1.62	No	Yes	0	4	1
264	R:R:S14	R:R:T15	1.6	No	No	0	7	4
265	R:R:V23	R:R:V27	1.6	No	No	0	5	5
266	R:R:V140	R:R:V144	1.6	No	No	0	3	5
267	R:R:S172	R:R:T170	1.6	No	No	0	4	5
268	R:R:V181	R:R:V185	1.6	No	No	0	4	4
269	R:R:V185	R:R:V189	1.6	No	No	0	4	5
270	R:R:T20	R:R:V24	1.59	No	No	0	5	5
271	R:R:T148	R:R:V144	1.59	No	No	0	4	5
272	R:R:A279	R:R:L28	1.58	No	No	0	5	7
273	R:R:A238	R:R:L287	1.58	No	Yes	0	6	8
274	R:R:A242	R:R:L283	1.58	No	No	2	6	6
275	R:R:A242	R:R:L287	1.58	No	Yes	2	6	8
276	R:R:C91	R:R:N92	1.57	Yes	No	0	9	6
277	R:R:I19	R:R:V23	1.54	No	No	0	7	5
278	R:R:I216	R:R:T226	1.52	No	No	8	5	3
279	R:R:I227	R:R:T226	1.52	No	No	8	5	3
280	R:R:K18	R:R:T22	1.5	No	No	0	4	5
281	R:R:G44	R:R:R47	1.5	No	No	0	2	6
282	R:R:K231	R:R:T235	1.5	No	No	0	8	8
283	R:R:L97	R:R:V71	1.49	No	No	0	5	6
284	R:R:L152	R:R:T148	1.47	No	No	0	6	4
285	R:R:L291	R:R:T235	1.47	No	No	0	7	8
286	R:R:Q212	R:R:V208	1.43	No	No	0	6	5
287	R:R:G87	R:R:W84	1.41	No	Yes	0	8	8
288	R:R:L41	R:R:L45	1.38	No	No	9	4	5
289	R:R:L302	R:R:L41	1.38	No	No	9	5	4
290	R:R:D122	R:R:L124	1.36	No	No	0	6	6
291	R:R:E229	R:R:K214	1.35	No	No	0	7	4
292	R:R:N162	R:R:R161	1.21	No	No	0	4	1
293	R:R:D294	R:R:R293	1.19	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.2878	9	1	0
2	R:R:L25	4.925	4	0	7
3	R:R:N36	4.958	5	0	9
4	R:R:F56	6.30333	6	0	8
5	R:R:D64	7.7825	4	0	9
6	R:R:L65	4.2725	4	4	7
7	R:R:W84	9.68375	8	3	8
8	R:R:F86	7.824	5	3	6
9	R:R:C91	4.2675	4	3	9
10	R:R:D98	7.325	4	1	5
11	R:R:M100	5.365	4	6	5
12	R:R:F110	7.3225	4	0	7
13	R:R:Y117	9.0425	4	0	7
14	R:R:Y126	7.272	5	0	7
15	R:R:F151	7.3125	4	6	3
16	R:R:Y182	5.875	4	0	5
17	R:R:D186	8.2075	4	1	4
18	R:R:T190	4.31	5	1	5
19	R:R:F191	7.81167	6	1	8
20	R:R:M198	5.725	4	0	8
21	R:R:Y202	6.505	4	0	9
22	R:R:W247	7.82429	7	1	8
23	R:R:Y250	7.97	4	0	6
24	R:R:F251	9.2225	4	1	7
25	R:R:R257	6.42	5	7	4
26	R:R:I265	4.955	4	7	1
27	R:R:Y278	9.974	5	0	6
28	R:R:N284	7.758	5	2	9
29	R:R:L287	2.3625	4	2	8
30	R:R:Y288	5.654	5	2	9
31	R:R:F295	4.88	7	0	8
32	R:R:Y299	4.575	4	0	6
33	R:R:Q301	8.5525	4	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D98	19.2435	8.76	Yes	Yes	1	0	5
2	R:R:D98	R:R:Y278	33.4988	11.49	Yes	Yes	0	5	6
3	R:R:W275	R:R:Y278	16.2491	9.65	No	Yes	0	5	6
4	R:R:L25	R:R:W275	11.4657	7.97	Yes	No	0	7	5
5	L:L:?1	R:R:C102	17.6818	8.78	Yes	No	1	0	7
6	R:R:C102	R:R:W247	38.991	5.22	No	Yes	1	7	8
7	R:R:N280	R:R:W247	100	6.78	No	Yes	0	9	8
8	R:R:N280	R:R:N284	98.0139	6.81	No	Yes	0	9	9
9	R:R:D64	R:R:N284	71.6863	6.73	Yes	Yes	0	9	9
10	R:R:D64	R:R:N36	67.8202	6.73	Yes	Yes	0	9	9
11	L:L:?1	R:R:Y250	18.2959	18.37	Yes	Yes	0	0	6
12	R:R:W247	R:R:Y250	35.9209	3.86	Yes	Yes	0	8	6
13	L:L:?1	R:R:F251	37.5621	8.98	Yes	Yes	1	0	7
14	R:R:F251	R:R:W247	25.9372	9.02	Yes	Yes	1	7	8
15	R:R:L65	R:R:N36	14.5283	5.49	Yes	Yes	0	7	9
16	R:R:A61	R:R:N36	38.847	3.13	No	Yes	0	9	9
17	R:R:A61	R:R:V39	34.4351	3.39	No	No	0	9	9
18	R:R:V39	R:R:Y299	32.9492	2.52	No	Yes	0	9	6
19	R:R:F295	R:R:Y299	28.4426	4.13	Yes	Yes	0	8	6
20	R:R:N284	R:R:Y288	36.5955	4.65	Yes	Yes	2	9	9
21	R:R:I112	R:R:Y288	28.5297	4.84	No	Yes	2	9	9
22	R:R:F56	R:R:I112	27.3434	3.77	Yes	No	0	8	9
23	R:R:F56	R:R:V135	18.7962	7.87	Yes	No	0	8	7
24	R:R:L52	R:R:V135	17.39	4.47	No	No	0	6	7
25	L:L:?1	R:R:D186	37.7137	15.01	Yes	Yes	1	0	4
26	R:R:D186	R:R:L149	13.1145	5.43	Yes	No	0	4	5
27	R:R:I145	R:R:L149	11.5036	2.85	No	No	0	5	5
28	R:R:I145	R:R:L107	10.177	2.85	No	No	0	5	5
29	R:R:L52	R:R:P132	15.9762	9.85	No	No	0	6	2
30	R:R:D186	R:R:Y182	41.8148	8.05	Yes	Yes	0	4	5
31	R:R:N159	R:R:Y182	25.7855	8.14	No	Yes	0	5	5
32	R:R:I154	R:R:N159	18.5688	8.5	No	No	0	4	5
33	R:R:I154	R:R:S96	16.7456	4.64	No	No	0	4	4
34	R:R:F151	R:R:S96	14.9149	11.89	Yes	No	0	3	4
35	R:R:S75	R:R:Y278	30.1937	7.63	No	Yes	0	6	6
36	R:R:S75	R:R:Y94	28.6965	6.36	No	No	0	6	5
37	R:R:W84	R:R:Y94	27.1918	14.47	Yes	No	0	8	5
38	R:R:F191	R:R:F251	26.7559	15	Yes	Yes	1	8	7
39	R:R:F191	R:R:F243	49.1832	7.5	Yes	No	1	8	9
40	R:R:F243	R:R:M198	48.4365	7.46	No	Yes	0	9	8
41	R:R:M198	R:R:S113	27.2865	6.13	Yes	No	0	8	9
42	R:R:S113	R:R:Y202	11.6931	12.72	No	Yes	0	9	9
43	R:R:M198	R:R:M240	13.7285	4.33	Yes	No	0	8	8
44	R:R:M240	R:R:Y202	11.3179	5.99	No	Yes	0	8	9
45	R:R:S113	R:R:T201	15.4304	3.2	No	No	0	9	7
46	R:R:T201	R:R:Y117	14.1796	8.74	No	Yes	0	7	7
47	R:R:P132	R:R:T131	14.5548	5.25	No	No	0	2	8
48	R:R:S153	R:R:Y182	13.0766	3.82	No	Yes	0	5	5
49	R:R:S153	R:R:W158	11.2307	7.41	No	No	0	5	4
50	L:L:?1	R:R:F254	47.8452	6.74	Yes	No	0	0	4
51	R:R:F254	R:R:V178	44.7258	15.73	No	No	0	4	1
52	R:R:R257	R:R:V178	41.7238	7.85	Yes	No	0	4	1
53	R:R:D262	R:R:R257	16.6698	4.76	No	Yes	0	1	4
54	R:R:D262	R:R:R161	11.7462	4.76	No	No	0	1	1
55	R:R:L236	R:R:Y202	17.7993	3.52	No	Yes	0	7	9
56	R:R:F206	R:R:L236	15.2788	3.65	No	No	0	5	7
57	R:R:L274	R:R:Y250	18.0002	5.86	No	Yes	0	5	6
58	R:R:E270	R:R:R257	11.6173	5.82	No	Yes	7	4	4
59	R:R:E267	R:R:E270	10.0936	2.54	No	No	0	4	4
60	R:R:N36	R:R:T32	12.9439	2.92	Yes	No	0	9	8
61	R:R:C102	R:R:D98	21.2144	4.67	No	Yes	1	7	5
62	R:R:F191	R:R:W247	31.7363	5.01	Yes	Yes	1	8	8
63	R:R:L274	R:R:Y278	17.3407	14.07	No	Yes	0	5	6
64	R:R:D186	R:R:T190	13.0577	4.34	Yes	Yes	1	4	5
65	R:R:F251	R:R:T190	15.1575	3.89	Yes	Yes	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D98	8.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V99	12.36	1	Yes	No	0	4	0	1
L:L:?1	R:R:C102	8.78	1	Yes	No	0	7	0	1
L:L:?1	R:R:T103	8.15	1	Yes	No	0	6	0	1
L:L:?1	R:R:D186	15.01	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:T190	5.44	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y250	18.37	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F251	8.98	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F254	6.74	1	Yes	No	0	4	0	1
R:R:D98	R:R:V71	4.38	1	Yes	No	5	6	1	2
R:R:C102	R:R:D98	4.67	1	No	Yes	7	5	1	1
R:R:D98	R:R:Y278	11.49	1	Yes	Yes	5	6	1	2
R:R:C102	R:R:W247	5.22	1	No	Yes	7	8	1	2
R:R:S146	R:R:T103	6.4	0	No	No	8	6	2	1
R:R:T103	R:R:T190	4.71	1	No	Yes	6	5	1	1
R:R:D186	R:R:L149	5.43	1	Yes	No	4	5	1	2
R:R:F254	R:R:V178	15.73	0	No	No	4	1	1	2
R:R:D186	R:R:Y182	8.05	1	Yes	Yes	4	5	1	2
R:R:D186	R:R:T190	4.34	1	Yes	Yes	4	5	1	1
R:R:F251	R:R:T190	3.89	1	Yes	Yes	7	5	1	1
R:R:F191	R:R:W247	5.01	1	Yes	Yes	8	8	2	2
R:R:F191	R:R:F251	15	1	Yes	Yes	8	7	2	1
R:R:W247	R:R:Y250	3.86	1	Yes	Yes	8	6	2	1
R:R:F251	R:R:W247	9.02	1	Yes	Yes	7	8	1	2
R:R:V273	R:R:Y250	3.79	0	No	Yes	5	6	2	1
R:R:L274	R:R:Y250	5.86	0	No	Yes	5	6	2	1
R:R:L274	R:R:Y278	14.07	0	No	Yes	5	6	2	2
R:R:T190	R:R:V189	3.17	1	Yes	No	5	5	1	2
R:R:F254	R:R:G183	3.01	0	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YUT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	274
Number of Links	293
Number of Hubs	33
Number of Links mediated by Hubs	135
Number of Communities	9
Number of Nodes involved in Communities	45
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	51863
Length Of Smallest Path	3
Average Path Length	13.0872
Length of Longest Path	26
Minimum Path Strength	1.485
Average Path Strength	6.75401
Maximum Path Strength	19.16
Minimum Path Correlation	0.7
Average Path Correlation	0.936653
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	54.0288
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.1884
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • localization • multicellular organismal process • system process • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • regulation of tube diameter • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • immune response • immune system process • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25021
Sequence	>8YUT_nogp_Chain_R D S T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N R R L R N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S C K W S F G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D P L R Y P V L V T P V R V A I S L V L I W V I S I T L S F L S I H L G W N S R N E T S K G N H T T S K C K V Q V N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I N H I S S W K A A T I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R G D D A I N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D F R T G Y Q Q L F C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	7F16	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-	Gs/β1/γ2	2.8	2021-08-18	doi.org/10.1073/pnas.2101279118
	7F16 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-		2.8	2021-08-18	doi.org/10.1073/pnas.2101279118
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8YUT	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-	Gs/β1/γ2	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUT (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8WST	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	MCH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WST (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	MCH	-		2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8YN3	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN3 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN4	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN4 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	7UL3	A	Amine	Histamine	H₂	Homo sapiens	Famotidine	-	-	3	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8POK	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41467-024-46096-z
	8POK (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		3.4	2024-03-06	doi.org/10.1038/s41467-024-46096-z
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	9H2X	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 175670644	Na	-	1.75	2025-06-18	doi.org/10.1038/s41467-025-60629-0
	9IXJ	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	2.92	2025-07-30	To be published
	9IXJ (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.92	2025-07-30	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.