psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D98	11.5	Yes	Yes	1	0	5
2	L:L:?1	R:R:V99	7.01	Yes	No	0	0	4
3	L:L:?1	R:R:C102	8.96	Yes	Yes	1	0	7
4	L:L:?1	R:R:D186	8.94	Yes	Yes	1	0	4
5	L:L:?1	R:R:Y250	20.96	Yes	Yes	1	0	6
6	L:L:?1	R:R:F251	3.44	Yes	Yes	1	0	7
7	L:L:?1	R:R:F254	5.73	Yes	Yes	1	0	4
8	L:L:?1	R:R:Y278	4.41	Yes	Yes	1	0	6
9	R:R:I21	R:R:L25	7.14	No	Yes	1	4	7
10	R:R:I21	R:R:L80	4.28	No	No	1	4	4
11	R:R:L80	R:R:T22	8.84	No	No	0	4	5
12	R:R:L25	R:R:L80	4.15	Yes	No	1	7	4
13	R:R:L25	R:R:W275	7.97	Yes	Yes	1	7	5
14	R:R:I29	R:R:L72	4.28	No	Yes	0	6	7
15	R:R:L72	R:R:T32	4.42	Yes	No	0	7	8
16	R:R:A282	R:R:T32	3.36	No	No	0	7	8
17	R:R:L69	R:R:V33	4.47	No	No	0	5	6
18	R:R:G35	R:R:P285	4.06	No	No	0	8	9
19	R:R:D64	R:R:N36	6.73	Yes	No	0	9	9
20	R:R:N36	R:R:P285	11.4	No	No	0	9	9
21	R:R:V38	R:R:Y299	5.05	No	No	0	7	6
22	R:R:A61	R:R:V39	3.39	No	No	0	9	9
23	R:R:P285	R:R:V39	3.53	No	No	0	9	9
24	R:R:A289	R:R:V39	3.39	No	No	0	7	9
25	R:R:V43	R:R:V58	4.81	No	No	0	7	5
26	R:R:L302	R:R:L45	9.69	No	No	0	5	5
27	R:R:L49	R:R:N46	9.61	No	Yes	0	7	5
28	R:R:G298	R:R:N46	5.09	No	Yes	0	5	5
29	R:R:L302	R:R:N46	6.87	No	Yes	0	5	5
30	R:R:L49	R:R:R48	7.29	No	No	0	7	6
31	R:R:D294	R:R:R48	4.76	No	No	0	6	6
32	R:R:R48	R:R:T297	5.17	No	No	0	6	4
33	R:R:F295	R:R:L49	7.31	Yes	No	0	8	7
34	R:R:N51	R:R:T53	8.77	No	No	4	7	8
35	R:R:N51	R:R:N54	9.54	No	No	4	7	8
36	R:R:C55	R:R:L52	4.76	No	No	0	4	6
37	R:R:L52	R:R:P132	8.21	No	No	0	6	2
38	R:R:L52	R:R:V135	7.45	No	No	0	6	7
39	R:R:N54	R:R:T53	5.85	No	No	4	8	8
40	R:R:F295	R:R:N54	12.08	Yes	No	0	8	8
41	R:R:F56	R:R:M111	7.46	No	Yes	0	8	6
42	R:R:F56	R:R:I112	3.77	No	No	0	8	9
43	R:R:F56	R:R:V135	9.18	No	No	0	8	7
44	R:R:N108	R:R:S59	5.96	No	No	0	8	9
45	R:R:D64	R:R:L60	8.14	Yes	Yes	2	9	9
46	R:R:L60	R:R:N108	5.49	Yes	No	0	9	8
47	R:R:L109	R:R:L60	5.54	No	Yes	2	8	9
48	R:R:L60	R:R:N284	12.36	Yes	Yes	2	9	9
49	R:R:T63	R:R:W143	3.64	No	No	0	8	9
50	R:R:D64	R:R:S105	5.89	Yes	No	0	9	9
51	R:R:D64	R:R:S281	11.78	Yes	No	0	9	9
52	R:R:D64	R:R:N284	6.73	Yes	Yes	2	9	9
53	R:R:L65	R:R:L69	4.15	No	No	0	7	5
54	R:R:L101	R:R:L66	4.15	No	No	0	7	7
55	R:R:L67	R:R:V71	4.47	Yes	No	0	8	6
56	R:R:L101	R:R:L67	5.54	No	Yes	0	7	8
57	R:R:C102	R:R:L67	4.76	Yes	Yes	0	7	8
58	R:R:L67	R:R:S281	4.5	Yes	No	0	8	9
59	R:R:G68	R:R:L72	5.13	No	Yes	0	7	7
60	R:R:D98	R:R:V71	7.3	Yes	No	1	5	6
61	R:R:V71	R:R:Y278	3.79	No	Yes	1	6	6
62	R:R:L72	R:R:W275	3.42	Yes	Yes	1	7	5
63	R:R:L72	R:R:Y278	5.86	Yes	Yes	1	7	6
64	R:R:F74	R:R:F86	6.43	No	Yes	3	5	6
65	R:R:F74	R:R:F90	5.36	No	No	3	5	6
66	R:R:S75	R:R:Y94	6.36	No	No	0	6	5
67	R:R:S75	R:R:Y278	5.09	No	Yes	0	6	6
68	R:R:W84	R:R:Y78	9.65	Yes	No	0	8	4
69	R:R:A271	R:R:Q79	4.55	No	No	0	4	3
70	R:R:Q79	R:R:W275	4.38	No	Yes	0	3	5
71	R:R:K83	R:R:S172	6.12	No	No	0	5	4
72	R:R:F86	R:R:W84	17.04	Yes	Yes	3	6	8
73	R:R:F90	R:R:W84	6.01	No	Yes	3	6	8
74	R:R:C91	R:R:W84	5.22	No	Yes	3	9	8
75	R:R:W84	R:R:Y94	12.54	Yes	No	0	8	5
76	R:R:C174	R:R:W84	13.06	No	Yes	3	9	8
77	R:R:F86	R:R:S85	5.28	Yes	No	0	6	3
78	R:R:F86	R:R:F90	8.57	Yes	No	3	6	6
79	R:R:C174	R:R:C91	7.28	No	No	3	9	9
80	R:R:I154	R:R:T95	4.56	No	No	0	4	5
81	R:R:F151	R:R:S96	11.89	Yes	No	0	3	4
82	R:R:I154	R:R:S96	7.74	No	No	0	4	4
83	R:R:F151	R:R:L97	3.65	Yes	No	0	3	5
84	R:R:C102	R:R:D98	4.67	Yes	Yes	1	7	5
85	R:R:D98	R:R:Y278	12.64	Yes	Yes	1	5	6
86	R:R:M100	R:R:W143	5.82	Yes	No	0	5	9
87	R:R:M100	R:R:S150	6.13	Yes	No	5	5	7
88	R:R:F151	R:R:M100	4.98	Yes	Yes	5	3	5
89	R:R:C102	R:R:W247	6.53	Yes	Yes	0	7	8
90	R:R:S146	R:R:T103	4.8	No	No	0	8	6
91	R:R:T103	R:R:T190	9.42	No	Yes	0	6	5
92	R:R:A104	R:R:W143	3.89	No	No	0	7	9
93	R:R:A104	R:R:S146	3.42	No	No	0	7	8
94	R:R:I106	R:R:T190	4.56	No	Yes	0	7	5
95	R:R:I106	R:R:W247	17.62	No	Yes	0	7	8
96	R:R:I142	R:R:L107	4.28	No	No	0	6	5
97	R:R:I142	R:R:N108	4.25	No	No	0	6	8
98	R:R:L109	R:R:N284	5.49	No	Yes	2	8	9
99	R:R:L109	R:R:Y288	7.03	No	Yes	2	8	9
100	R:R:F110	R:R:L114	8.53	No	No	0	7	6
101	R:R:F110	R:R:P194	8.67	No	No	0	7	8
102	R:R:F110	R:R:I197	8.79	No	No	0	7	6
103	R:R:I142	R:R:M111	4.37	No	Yes	0	6	6
104	R:R:I112	R:R:R116	6.26	No	No	2	9	9
105	R:R:I112	R:R:Y288	7.25	No	Yes	2	9	9
106	R:R:M198	R:R:S113	6.13	No	No	0	8	9
107	R:R:S113	R:R:Y202	3.82	No	Yes	0	9	9
108	R:R:D115	R:R:Y126	5.75	No	Yes	0	8	7
109	R:R:R116	R:R:Y202	7.2	No	Yes	0	9	9
110	R:R:R116	R:R:Y288	7.2	No	Yes	2	9	9
111	R:R:M121	R:R:Y117	13.17	No	No	0	7	7
112	R:R:T201	R:R:Y117	8.74	No	No	0	7	7
113	R:R:R204	R:R:Y117	10.29	No	No	0	3	7
114	R:R:A119	R:R:Y126	4	No	Yes	0	8	7
115	R:R:I205	R:R:V120	4.61	No	No	0	8	8
116	R:R:V120	R:R:V208	4.81	No	No	0	8	5
117	R:R:D122	R:R:R125	19.06	No	No	0	6	5
118	R:R:P127	R:R:Y126	5.56	No	Yes	0	4	7
119	R:R:V130	R:R:Y126	11.36	No	Yes	0	7	7
120	R:R:P132	R:R:T131	5.25	No	No	0	2	8
121	R:R:R134	R:R:T131	5.17	No	No	0	5	8
122	R:R:F151	R:R:S150	6.61	Yes	No	5	3	7
123	R:R:S153	R:R:W158	9.88	No	No	0	5	4
124	R:R:S153	R:R:Y182	7.63	No	Yes	0	5	5
125	R:R:I154	R:R:N159	9.91	No	No	0	4	5
126	R:R:L156	R:R:W158	10.25	No	No	0	3	4
127	R:R:G157	R:R:S160	3.71	No	No	0	4	4
128	R:R:N159	R:R:Y182	6.98	No	Yes	0	5	5
129	R:R:G261	R:R:R161	4.5	No	No	0	4	1
130	R:R:D262	R:R:R161	4.76	No	No	0	1	1
131	R:R:K173	R:R:K175	7.18	No	No	0	4	4
132	R:R:K175	R:R:Q177	8.14	No	No	0	4	3
133	R:R:V178	R:R:Y182	3.79	Yes	Yes	1	1	5
134	R:R:F254	R:R:V178	11.8	Yes	Yes	1	4	1
135	R:R:R257	R:R:V178	6.54	No	Yes	0	4	1
136	R:R:G258	R:R:V178	5.52	No	Yes	0	4	1
137	R:R:N179	R:R:Y182	4.65	No	Yes	0	4	5
138	R:R:D186	R:R:Y182	11.49	Yes	Yes	1	4	5
139	R:R:F254	R:R:Y182	4.13	Yes	Yes	1	4	5
140	R:R:D186	R:R:T190	5.78	Yes	Yes	0	4	5
141	R:R:D186	R:R:F254	5.97	Yes	Yes	1	4	4
142	R:R:L188	R:R:Y192	3.52	No	No	0	5	4
143	R:R:F251	R:R:T190	5.19	Yes	Yes	0	7	5
144	R:R:F191	R:R:Y192	10.32	Yes	No	0	8	4
145	R:R:F191	R:R:L195	6.09	Yes	No	1	8	7
146	R:R:F191	R:R:F243	8.57	Yes	No	1	8	9
147	R:R:F191	R:R:F248	7.5	Yes	No	0	8	5
148	R:R:F191	R:R:F251	13.93	Yes	Yes	1	8	7
149	R:R:T252	R:R:Y192	3.75	No	No	0	6	4
150	R:R:F243	R:R:L195	4.87	No	No	1	9	7
151	R:R:F243	R:R:M198	3.73	No	No	0	9	8
152	R:R:I200	R:R:R204	3.76	No	No	0	5	3
153	R:R:L236	R:R:Y202	3.52	No	Yes	0	7	9
154	R:R:V239	R:R:Y202	3.79	No	Yes	0	8	9
155	R:R:M240	R:R:Y202	8.38	No	Yes	0	8	9
156	R:R:K207	R:R:Y203	7.17	No	No	0	4	3
157	R:R:F206	R:R:R210	8.55	No	No	0	5	5
158	R:R:F206	R:R:T233	9.08	No	No	0	5	6
159	R:R:F206	R:R:L236	3.65	No	No	0	5	7
160	R:R:K214	R:R:R210	3.71	No	No	0	4	5
161	R:R:D211	R:R:K214	5.53	No	No	0	4	4
162	R:R:D211	R:R:R215	4.76	No	No	0	4	4
163	R:R:Q212	R:R:R215	5.84	No	No	0	6	4
164	R:R:H230	R:R:T233	5.48	No	No	0	5	6
165	R:R:V239	R:R:Y288	5.05	No	Yes	0	8	9
166	R:R:C246	R:R:N280	7.87	No	No	0	9	9
167	R:R:F251	R:R:W247	4.01	Yes	Yes	0	7	8
168	R:R:G277	R:R:W247	8.44	No	Yes	0	7	8
169	R:R:N280	R:R:W247	10.17	No	Yes	0	9	8
170	R:R:F248	R:R:P249	4.33	No	No	0	5	9
171	R:R:F248	R:R:T252	7.78	No	No	0	5	6
172	R:R:L276	R:R:P249	3.28	No	No	0	7	9
173	R:R:F251	R:R:Y250	5.16	Yes	Yes	1	7	6
174	R:R:F254	R:R:Y250	5.16	Yes	Yes	1	4	6
175	R:R:V273	R:R:Y250	3.79	No	Yes	0	5	6
176	R:R:L274	R:R:Y250	7.03	No	Yes	0	5	6
177	R:R:R260	R:R:Y256	9.26	No	No	0	4	4
178	R:R:I265	R:R:Y256	4.84	No	No	0	1	4
179	R:R:D262	R:R:R257	4.76	No	No	0	1	4
180	R:R:N266	R:R:V268	5.91	No	No	0	4	1
181	R:R:L274	R:R:Y278	10.55	No	Yes	0	5	6
182	R:R:W275	R:R:Y278	10.61	Yes	Yes	1	5	6
183	R:R:N280	R:R:N284	9.54	No	Yes	0	9	9
184	R:R:F295	R:R:N292	10.87	Yes	No	0	8	8
185	R:R:R293	R:R:R296	7.46	No	No	0	5	8
186	R:R:F295	R:R:Y299	4.13	Yes	No	0	8	6
187	R:R:D122	R:R:P123	3.22	No	No	0	6	8
188	R:R:V23	R:R:V24	3.21	No	No	0	5	5
189	R:R:V176	R:R:V99	3.21	No	No	0	5	4
190	R:R:R47	R:R:R50	3.2	No	No	0	6	7
191	R:R:T131	R:R:V133	3.17	No	No	0	8	4
192	R:R:C199	R:R:L195	3.17	No	No	0	5	7
193	R:R:A76	R:R:L25	3.15	No	Yes	0	6	7
194	R:R:A34	R:R:L30	3.15	No	No	0	5	5
195	R:R:C91	R:R:N92	3.15	No	No	0	9	6
196	R:R:I31	R:R:V27	3.07	No	No	0	5	5
197	R:R:I62	R:R:V58	3.07	No	No	0	6	5
198	R:R:M111	R:R:S138	3.07	Yes	No	0	6	6
199	R:R:F251	R:R:G187	3.01	Yes	No	0	7	5
200	R:R:G44	R:R:R50	3	No	No	0	2	7
201	R:R:L139	R:R:S59	3	No	No	0	7	9
202	R:R:L149	R:R:S153	3	No	No	0	5	5
203	R:R:L41	R:R:V37	2.98	No	No	0	4	4
204	R:R:L65	R:R:V37	2.98	No	No	0	7	4
205	R:R:L129	R:R:V128	2.98	No	No	0	4	5
206	R:R:L259	R:R:V255	2.98	No	No	0	5	5
207	R:R:N179	R:R:V181	2.96	No	No	0	4	4
208	R:R:I147	R:R:M100	2.92	No	Yes	0	4	5
209	R:R:I244	R:R:M240	2.92	No	No	0	6	8
210	R:R:I93	R:R:L97	2.85	No	No	0	5	5
211	R:R:I145	R:R:L107	2.85	No	No	0	5	5
212	R:R:I137	R:R:L141	2.85	No	No	0	4	4
213	R:R:I200	R:R:L196	2.85	No	No	0	5	4
214	R:R:L114	R:R:M111	2.83	No	Yes	0	6	6
215	R:R:H155	R:R:S96	2.79	No	No	0	4	4
216	R:R:A42	R:R:F295	2.77	No	Yes	0	8	8
217	R:R:L283	R:R:L287	2.77	No	Yes	2	6	8
218	R:R:A289	R:R:F295	2.77	No	Yes	0	7	8
219	R:R:L65	R:R:N36	2.75	No	No	0	7	9
220	R:R:E270	R:R:I265	2.73	No	No	0	4	1
221	R:R:A264	R:R:Y256	2.67	No	No	0	2	4
222	R:R:N46	R:R:Q301	2.64	Yes	No	0	5	4
223	R:R:F295	R:R:V43	2.62	Yes	No	0	8	7
224	R:R:F295	R:R:I57	2.51	Yes	No	0	8	8
225	R:R:I265	R:R:R257	2.51	No	No	0	1	4
226	R:R:T53	R:R:Y126	2.5	No	Yes	0	8	7
227	R:R:L129	R:R:R125	2.43	No	No	0	4	5
228	R:R:L129	R:R:R134	2.43	No	No	0	4	5
229	R:R:I205	R:R:Y202	2.42	No	Yes	0	8	9
230	R:R:L287	R:R:Y288	2.34	Yes	Yes	2	8	9
231	R:R:L152	R:R:W158	2.28	No	No	0	6	4
232	R:R:A34	R:R:G35	1.95	No	No	0	5	8
233	R:R:G183	R:R:V178	1.84	No	Yes	0	5	1
234	R:R:G187	R:R:V255	1.84	No	No	0	5	5
235	R:R:A61	R:R:C40	1.81	No	No	0	9	7
236	R:R:A209	R:R:A232	1.79	No	No	0	8	7
237	R:R:C118	R:R:V130	1.71	No	No	0	5	7
238	R:R:A253	R:R:V273	1.7	No	No	0	4	5
239	R:R:A16	R:R:T15	1.68	No	No	0	5	4
240	R:R:L72	R:R:P73	1.64	Yes	No	0	7	8
241	R:R:L193	R:R:P194	1.64	No	No	0	6	8
242	R:R:A282	R:R:I31	1.62	No	No	0	7	5
243	R:R:A290	R:R:I286	1.62	No	No	0	6	7
244	R:R:S113	R:R:T201	1.6	No	No	0	9	7
245	R:R:V140	R:R:V144	1.6	No	No	0	3	5
246	R:R:V181	R:R:V185	1.6	No	No	0	4	4
247	R:R:T148	R:R:V144	1.59	No	No	0	4	5
248	R:R:A279	R:R:L28	1.58	No	No	0	5	7
249	R:R:A238	R:R:L287	1.58	No	Yes	0	6	8
250	R:R:A242	R:R:L283	1.58	No	No	2	6	6
251	R:R:A242	R:R:L287	1.58	No	Yes	2	6	8
252	R:R:I77	R:R:S81	1.55	No	No	0	4	4
253	R:R:I19	R:R:V23	1.54	No	No	0	7	5
254	R:R:I137	R:R:V133	1.54	No	No	0	4	4
255	R:R:F86	R:R:G87	1.51	Yes	No	0	6	8
256	R:R:K88	R:R:T171	1.5	No	No	0	3	1
257	R:R:K231	R:R:T235	1.5	No	No	0	8	8
258	R:R:L184	R:R:V255	1.49	No	No	0	4	5
259	R:R:L269	R:R:V273	1.49	No	No	0	5	5
260	R:R:L28	R:R:T32	1.47	No	No	0	7	8
261	R:R:L152	R:R:T148	1.47	No	No	0	6	4
262	R:R:L291	R:R:T235	1.47	No	No	0	7	8
263	R:R:I21	R:R:K18	1.45	No	No	0	4	4
264	R:R:Q177	R:R:S160	1.44	No	No	0	3	4
265	R:R:E180	R:R:V181	1.43	No	No	0	2	4
266	R:R:L66	R:R:L70	1.38	No	No	0	7	5
267	R:R:L70	R:R:L97	1.38	No	No	0	5	5
268	R:R:D262	R:R:K175	1.38	No	No	0	1	4
269	R:R:H230	R:R:V234	1.38	No	No	0	5	7
270	R:R:L269	R:R:N266	1.37	No	No	0	5	4
271	R:R:D122	R:R:L124	1.36	No	No	0	6	6
272	R:R:R50	R:R:V43	1.31	No	No	0	7	7
273	R:R:E267	R:R:N266	1.31	No	No	0	4	4
274	R:R:K231	R:R:R228	1.24	No	No	0	8	6
275	R:R:E229	R:R:H230	1.23	No	No	0	7	5
276	R:R:N292	R:R:R293	1.21	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.86875	8	1	0
2	R:R:L25	5.6025	4	1	7
3	R:R:N46	6.0525	4	0	5
4	R:R:L60	7.8825	4	2	9
5	R:R:D64	7.854	5	2	9
6	R:R:L67	4.8175	4	0	8
7	R:R:L72	4.125	6	1	7
8	R:R:W84	10.5867	6	3	8
9	R:R:F86	7.766	5	3	6
10	R:R:D98	9.0275	4	1	5
11	R:R:M100	4.9625	4	5	5
12	R:R:C102	6.23	4	1	7
13	R:R:M111	4.4325	4	0	6
14	R:R:Y126	5.834	5	0	7
15	R:R:F151	6.7825	4	5	3
16	R:R:V178	5.898	5	1	1
17	R:R:Y182	6.445	6	1	5
18	R:R:D186	8.045	4	1	4
19	R:R:T190	6.2375	4	0	5
20	R:R:F191	9.282	5	1	8
21	R:R:Y202	4.855	6	0	9
22	R:R:W247	9.354	5	0	8
23	R:R:Y250	8.42	5	1	6
24	R:R:F251	5.79	6	1	7
25	R:R:F254	6.558	5	1	4
26	R:R:W275	6.595	4	1	5
27	R:R:Y278	7.56429	7	1	6
28	R:R:N284	8.53	4	2	9
29	R:R:L287	2.0675	4	2	8
30	R:R:Y288	5.774	5	2	9
31	R:R:F295	5.6325	8	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y278	35.702	4.41	Yes	Yes	1	0	6
2	R:R:W275	R:R:Y278	18.4524	10.61	Yes	Yes	1	5	6
3	R:R:L25	R:R:W275	12.8929	7.97	Yes	Yes	1	7	5
4	R:R:L72	R:R:Y278	21.7782	5.86	Yes	Yes	1	7	6
5	R:R:L72	R:R:T32	13.497	4.42	Yes	No	0	7	8
6	L:L:?1	R:R:C102	42.5586	8.96	Yes	Yes	1	0	7
7	R:R:C102	R:R:L67	24.9266	4.76	Yes	Yes	0	7	8
8	R:R:L67	R:R:S281	58.2063	4.5	Yes	No	0	8	9
9	R:R:D64	R:R:S281	58.5444	11.78	Yes	No	0	9	9
10	R:R:D64	R:R:N36	85.4997	6.73	Yes	No	0	9	9
11	R:R:L65	R:R:N36	10.4983	2.75	No	No	0	7	9
12	R:R:N36	R:R:P285	75.5889	11.4	No	No	0	9	9
13	R:R:P285	R:R:V39	68.76	3.53	No	No	0	9	9
14	R:R:A289	R:R:V39	63.522	3.39	No	No	0	7	9
15	R:R:A289	R:R:F295	61.7538	2.77	No	Yes	0	7	8
16	R:R:F295	R:R:V43	12.5159	2.62	Yes	No	0	8	7
17	R:R:F295	R:R:L49	18.7018	7.31	Yes	No	0	8	7
18	R:R:L49	R:R:N46	10.4983	9.61	No	Yes	0	7	5
19	R:R:F295	R:R:N54	17.9702	12.08	Yes	No	0	8	8
20	R:R:N54	R:R:T53	14.0901	5.85	No	No	4	8	8
21	R:R:C102	R:R:W247	26.6449	6.53	Yes	Yes	0	7	8
22	R:R:N280	R:R:W247	76.9081	10.17	No	Yes	0	9	8
23	R:R:N280	R:R:N284	74.5025	9.54	No	Yes	0	9	9
24	R:R:L109	R:R:N284	73.2609	5.49	No	Yes	2	8	9
25	R:R:L109	R:R:Y288	100	7.03	No	Yes	2	8	9
26	R:R:I112	R:R:Y288	48.617	7.25	No	Yes	2	9	9
27	R:R:F56	R:R:I112	50.8786	3.77	No	No	0	8	9
28	R:R:F56	R:R:V135	54.8972	9.18	No	No	0	8	7
29	R:R:L52	R:R:V135	51.7377	7.45	No	No	0	6	7
30	L:L:?1	R:R:F251	44.5818	3.44	Yes	Yes	1	0	7
31	R:R:F251	R:R:W247	47.9574	4.01	Yes	Yes	0	7	8
32	R:R:L52	R:R:P132	44.41	8.21	No	No	0	6	2
33	R:R:D64	R:R:L60	47.9297	8.14	Yes	Yes	2	9	9
34	R:R:L60	R:R:N108	36.0623	5.49	Yes	No	0	9	8
35	R:R:I142	R:R:N108	29.6325	4.25	No	No	0	6	8
36	R:R:I142	R:R:M111	24.1949	4.37	No	Yes	0	6	6
37	R:R:L60	R:R:N284	16.8006	12.36	Yes	Yes	2	9	9
38	L:L:?1	R:R:D186	26.5395	8.94	Yes	Yes	1	0	4
39	R:R:D186	R:R:T190	17.5655	5.78	Yes	Yes	0	4	5
40	R:R:T103	R:R:T190	13.0591	9.42	No	Yes	0	6	5
41	R:R:S146	R:R:T103	10.975	4.8	No	No	0	8	6
42	R:R:F251	R:R:T190	17.6376	5.19	Yes	Yes	0	7	5
43	R:R:L101	R:R:L67	15.232	5.54	No	Yes	0	7	8
44	R:R:L101	R:R:L66	13.3252	4.15	No	No	0	7	7
45	R:R:V71	R:R:Y278	26.146	3.79	No	Yes	1	6	6
46	R:R:S75	R:R:Y278	27.8588	5.09	No	Yes	0	6	6
47	R:R:S75	R:R:Y94	25.9963	6.36	No	No	0	6	5
48	R:R:W84	R:R:Y94	24.1395	12.54	Yes	No	0	8	5
49	R:R:D186	R:R:Y182	37.5755	11.49	Yes	Yes	1	4	5
50	R:R:N159	R:R:Y182	21.6507	6.98	No	Yes	0	5	5
51	R:R:I154	R:R:N159	17.6598	9.91	No	No	0	4	5
52	L:L:?1	R:R:F254	46.3777	5.73	Yes	Yes	1	0	4
53	R:R:F254	R:R:Y182	32.8363	4.13	Yes	Yes	1	4	5
54	R:R:I154	R:R:S96	10.2212	7.74	No	No	0	4	4
55	R:R:L66	R:R:L70	11.4517	1.38	No	No	0	7	5
56	R:R:L114	R:R:M111	12.2166	2.83	No	Yes	0	6	6
57	R:R:R116	R:R:Y288	19.8381	7.2	No	Yes	2	9	9
58	R:R:F191	R:R:F251	43.5231	13.93	Yes	Yes	1	8	7
59	R:R:F191	R:R:F243	31.5448	8.57	Yes	No	1	8	9
60	R:R:F243	R:R:M198	31.0681	3.73	No	No	0	9	8
61	R:R:M198	R:R:S113	31.2677	6.13	No	No	0	8	9
62	R:R:S113	R:R:Y202	33.5957	3.82	No	Yes	0	9	9
63	R:R:R116	R:R:Y202	23.4965	7.2	No	Yes	0	9	9
64	R:R:T53	R:R:Y126	12.067	2.5	No	Yes	0	8	7
65	R:R:S113	R:R:T201	15.8583	1.6	No	No	0	9	7
66	R:R:T201	R:R:Y117	13.2421	8.74	No	No	0	7	7
67	R:R:P132	R:R:T131	40.735	5.25	No	No	0	2	8
68	R:R:R134	R:R:T131	25.9021	5.17	No	No	0	5	8
69	R:R:L129	R:R:R134	22.1662	2.43	No	No	0	4	5
70	R:R:L129	R:R:R125	15.1377	2.43	No	No	0	4	5
71	R:R:D122	R:R:R125	11.3685	19.06	No	No	0	6	5
72	R:R:S153	R:R:Y182	32.4982	7.63	No	Yes	0	5	5
73	R:R:S153	R:R:W158	24.8379	9.88	No	No	0	5	4
74	R:R:F254	R:R:V178	31.7388	11.8	Yes	Yes	1	4	1
75	R:R:R257	R:R:V178	28.9784	6.54	No	Yes	0	4	1
76	R:R:D262	R:R:R257	16.6066	4.76	No	No	0	1	4
77	R:R:D262	R:R:K175	10.26	1.38	No	No	0	1	4
78	R:R:N179	R:R:Y182	16.6011	4.65	No	Yes	0	4	5
79	R:R:L236	R:R:Y202	29.8154	3.52	No	Yes	0	7	9
80	R:R:V239	R:R:Y288	20.0599	5.05	No	Yes	0	8	9
81	R:R:V239	R:R:Y202	18.5078	3.79	No	Yes	0	8	9
82	R:R:F206	R:R:L236	27.3544	3.65	No	No	0	5	7
83	R:R:F206	R:R:R210	13.9626	8.55	No	No	0	5	5
84	R:R:F206	R:R:T233	10.8974	9.08	No	No	0	5	6
85	R:R:K214	R:R:R210	11.1912	3.71	No	No	0	4	5
86	R:R:V273	R:R:Y250	10.6369	3.79	No	Yes	0	5	6
87	R:R:I265	R:R:R257	10.7755	2.51	No	No	0	1	4
88	R:R:T131	R:R:V133	11.3685	3.17	No	No	0	8	4
89	R:R:N179	R:R:V181	12.466	2.96	No	No	0	4	4
90	R:R:L287	R:R:Y288	13.5247	2.34	Yes	Yes	2	8	9
91	R:R:L152	R:R:W158	16.6011	2.28	No	No	0	6	4
92	R:R:L152	R:R:T148	12.466	1.47	No	No	0	6	4
93	R:R:L67	R:R:V71	26.8777	4.47	Yes	No	0	8	6
94	R:R:F254	R:R:Y250	19.0178	5.16	Yes	Yes	1	4	6
95	R:R:D64	R:R:N284	39.2661	6.73	Yes	Yes	2	9	9
96	R:R:F251	R:R:Y250	23.2858	5.16	Yes	Yes	1	7	6
97	R:R:F56	R:R:M111	11.812	7.46	No	Yes	0	8	6
98	R:R:L109	R:R:L60	29.3387	5.54	No	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D98	11.5	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V99	7.01	1	Yes	No	0	4	0	1
L:L:?1	R:R:C102	8.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:D186	8.94	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y250	20.96	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F251	3.44	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F254	5.73	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y278	4.41	1	Yes	Yes	0	6	0	1
R:R:L67	R:R:V71	4.47	0	Yes	No	8	6	2	2
R:R:C102	R:R:L67	4.76	1	Yes	Yes	7	8	1	2
R:R:D98	R:R:V71	7.3	1	Yes	No	5	6	1	2
R:R:V71	R:R:Y278	3.79	1	No	Yes	6	6	2	1
R:R:L72	R:R:W275	3.42	1	Yes	Yes	7	5	2	2
R:R:L72	R:R:Y278	5.86	1	Yes	Yes	7	6	2	1
R:R:S75	R:R:Y278	5.09	0	No	Yes	6	6	2	1
R:R:C102	R:R:D98	4.67	1	Yes	Yes	7	5	1	1
R:R:D98	R:R:Y278	12.64	1	Yes	Yes	5	6	1	1
R:R:C102	R:R:W247	6.53	1	Yes	Yes	7	8	1	2
R:R:V178	R:R:Y182	3.79	1	Yes	Yes	1	5	2	2
R:R:F254	R:R:V178	11.8	1	Yes	Yes	4	1	1	2
R:R:D186	R:R:Y182	11.49	1	Yes	Yes	4	5	1	2
R:R:F254	R:R:Y182	4.13	1	Yes	Yes	4	5	1	2
R:R:D186	R:R:T190	5.78	1	Yes	Yes	4	5	1	2
R:R:D186	R:R:F254	5.97	1	Yes	Yes	4	4	1	1
R:R:F251	R:R:T190	5.19	1	Yes	Yes	7	5	1	2
R:R:F191	R:R:F251	13.93	1	Yes	Yes	8	7	2	1
R:R:F251	R:R:W247	4.01	1	Yes	Yes	7	8	1	2
R:R:F251	R:R:Y250	5.16	1	Yes	Yes	7	6	1	1
R:R:F254	R:R:Y250	5.16	1	Yes	Yes	4	6	1	1
R:R:V273	R:R:Y250	3.79	0	No	Yes	5	6	2	1
R:R:L274	R:R:Y250	7.03	0	No	Yes	5	6	2	1
R:R:L274	R:R:Y278	10.55	0	No	Yes	5	6	2	1
R:R:W275	R:R:Y278	10.61	1	Yes	Yes	5	6	2	1
R:R:V176	R:R:V99	3.21	0	No	No	5	4	2	1
R:R:F251	R:R:G187	3.01	1	Yes	No	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YN4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	254
Number of Links	276
Number of Hubs	31
Number of Links mediated by Hubs	122
Number of Communities	5
Number of Nodes involved in Communities	41
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	53132
Length Of Smallest Path	3
Average Path Length	12.8193
Length of Longest Path	26
Minimum Path Strength	1.305
Average Path Strength	6.31176
Maximum Path Strength	16.23
Minimum Path Correlation	0.7
Average Path Correlation	0.92214
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	46.2222
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.0975
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	beta-aminoethylglyoxaline
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25021
Sequence	>8YN4_nogp_Chain_R T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N R R L R N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S C K W S F G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D P L R Y P V L V T P V R V A I S L V L I W V I S I T L S F L S I H L G W N S R T S K C K V Q V N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R G D D A I N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D F R T G Y Q Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	7F16	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-	Gs/β1/γ2	2.8	2021-08-18	doi.org/10.1073/pnas.2101279118
	7F16 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-		2.8	2021-08-18	doi.org/10.1073/pnas.2101279118
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8YUT	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-	Gs/β1/γ2	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUT (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8WST	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	MCH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WST (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	MCH	-		2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8YN3	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN3 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN4	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN4 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	7UL3	A	Amine	Histamine	H₂	Homo sapiens	Famotidine	-	-	3	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8POK	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41467-024-46096-z
	8POK (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		3.4	2024-03-06	doi.org/10.1038/s41467-024-46096-z
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	9H2X	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 175670644	Na	-	1.75	2025-06-18	doi.org/10.1038/s41467-025-60629-0
	9IXJ	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	2.92	2025-07-30	To be published
	9IXJ (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.92	2025-07-30	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.