psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D98	8.94	Yes	No	0	0	5
2	L:L:?1	R:R:V99	5.61	Yes	No	0	0	4
3	L:L:?1	R:R:C102	2.99	Yes	No	0	0	7
4	L:L:?1	R:R:D186	2.55	Yes	Yes	1	0	4
5	L:L:?1	R:R:Y250	20.96	Yes	Yes	1	0	6
6	L:L:?1	R:R:F251	3.44	Yes	Yes	1	0	7
7	R:R:C17	R:R:S14	3.44	No	No	0	3	7
8	R:R:I19	R:R:T15	3.04	No	No	0	7	4
9	R:R:I21	R:R:L25	2.85	No	No	0	4	7
10	R:R:I21	R:R:L80	2.85	No	No	0	4	4
11	R:R:L25	R:R:W275	4.56	No	Yes	0	7	5
12	R:R:I29	R:R:L72	12.85	No	No	0	6	7
13	R:R:L69	R:R:V33	7.45	No	No	0	5	6
14	R:R:G35	R:R:P285	4.06	No	No	0	8	9
15	R:R:D64	R:R:N36	5.39	Yes	No	0	9	9
16	R:R:N36	R:R:P285	4.89	No	No	0	9	9
17	R:R:L41	R:R:V37	2.98	No	No	0	4	4
18	R:R:L65	R:R:V37	2.98	Yes	No	0	7	4
19	R:R:V43	R:R:V58	4.81	No	No	0	7	5
20	R:R:F295	R:R:V43	2.62	No	No	0	8	7
21	R:R:R47	R:R:R48	18.13	No	No	0	6	6
22	R:R:L49	R:R:R47	12.15	No	No	0	7	6
23	R:R:R47	R:R:T297	3.88	No	No	0	6	4
24	R:R:N51	R:R:T53	5.85	No	No	0	7	8
25	R:R:N51	R:R:N54	10.9	No	No	0	7	8
26	R:R:L52	R:R:P132	8.21	No	No	0	6	2
27	R:R:T53	R:R:Y126	3.75	No	Yes	0	8	7
28	R:R:I57	R:R:N54	2.83	No	No	0	8	8
29	R:R:F56	R:R:M111	4.98	Yes	Yes	5	8	6
30	R:R:F56	R:R:I112	3.77	Yes	No	0	8	9
31	R:R:D115	R:R:F56	7.17	No	Yes	0	8	8
32	R:R:F56	R:R:S138	2.64	Yes	No	5	8	6
33	R:R:F56	R:R:L139	2.44	Yes	No	0	8	7
34	R:R:N108	R:R:S59	2.98	No	No	0	8	9
35	R:R:L139	R:R:S59	3	No	No	0	7	9
36	R:R:L60	R:R:N108	6.87	No	No	0	9	8
37	R:R:L60	R:R:N284	4.12	No	No	0	9	9
38	R:R:D64	R:R:L67	6.79	Yes	Yes	4	9	8
39	R:R:D64	R:R:S105	5.89	Yes	No	0	9	9
40	R:R:D64	R:R:S281	11.78	Yes	No	4	9	9
41	R:R:L65	R:R:L69	4.15	Yes	No	0	7	5
42	R:R:L67	R:R:V71	2.98	Yes	No	0	8	6
43	R:R:L101	R:R:L67	4.15	No	Yes	0	7	8
44	R:R:L67	R:R:S281	3	Yes	No	4	8	9
45	R:R:G68	R:R:L72	3.42	No	No	0	7	7
46	R:R:L70	R:R:L97	2.77	No	No	0	5	5
47	R:R:V71	R:R:Y94	2.52	No	Yes	0	6	5
48	R:R:D98	R:R:V71	5.84	No	No	0	5	6
49	R:R:L72	R:R:P73	4.93	No	No	0	7	8
50	R:R:F74	R:R:F86	4.29	No	No	2	5	6
51	R:R:F74	R:R:F90	5.36	No	No	2	5	6
52	R:R:S75	R:R:Y94	3.82	No	Yes	0	6	5
53	R:R:S75	R:R:W275	3.71	No	Yes	0	6	5
54	R:R:I77	R:R:S81	3.1	No	No	0	4	4
55	R:R:W84	R:R:Y78	3.86	Yes	No	0	8	4
56	R:R:K83	R:R:S85	7.65	No	No	0	5	3
57	R:R:F86	R:R:W84	18.04	No	Yes	2	6	8
58	R:R:G87	R:R:W84	2.81	No	Yes	0	8	8
59	R:R:F90	R:R:W84	7.02	No	Yes	2	6	8
60	R:R:C91	R:R:W84	3.92	No	Yes	2	9	8
61	R:R:W84	R:R:Y94	8.68	Yes	Yes	0	8	5
62	R:R:C174	R:R:W84	2.61	No	Yes	2	9	8
63	R:R:F86	R:R:F90	4.29	No	No	2	6	6
64	R:R:K88	R:R:N92	5.6	No	No	0	3	6
65	R:R:C174	R:R:C91	7.28	No	No	2	9	9
66	R:R:T95	R:R:Y94	2.5	No	Yes	0	5	5
67	R:R:F151	R:R:S96	5.28	Yes	No	0	3	4
68	R:R:I154	R:R:S96	4.64	No	No	0	4	4
69	R:R:F151	R:R:L97	2.44	Yes	No	0	3	5
70	R:R:D98	R:R:Y278	4.6	No	No	0	5	6
71	R:R:S150	R:R:V99	3.23	No	No	0	7	4
72	R:R:V176	R:R:V99	3.21	No	No	0	5	4
73	R:R:L101	R:R:M100	4.24	No	Yes	0	7	5
74	R:R:I147	R:R:M100	2.92	No	Yes	3	4	5
75	R:R:M100	R:R:S150	6.13	Yes	No	3	5	7
76	R:R:F151	R:R:M100	3.73	Yes	Yes	3	3	5
77	R:R:C102	R:R:W247	5.22	No	Yes	0	7	8
78	R:R:S146	R:R:T103	6.4	No	No	0	8	6
79	R:R:A104	R:R:W143	7.78	No	No	0	7	9
80	R:R:A104	R:R:S146	3.42	No	No	0	7	8
81	R:R:I106	R:R:L107	2.85	No	No	0	7	5
82	R:R:F191	R:R:I106	2.51	Yes	No	1	8	7
83	R:R:F243	R:R:I106	5.02	Yes	No	1	9	7
84	R:R:I142	R:R:L107	5.71	No	No	0	6	5
85	R:R:F243	R:R:L109	2.44	Yes	No	0	9	8
86	R:R:L109	R:R:Y288	9.38	No	No	0	8	9
87	R:R:F110	R:R:L114	4.87	Yes	No	0	7	6
88	R:R:F110	R:R:P194	5.78	Yes	No	0	7	8
89	R:R:F110	R:R:I197	6.28	Yes	No	0	7	6
90	R:R:M111	R:R:S138	3.07	Yes	No	5	6	6
91	R:R:I142	R:R:M111	2.92	No	Yes	0	6	6
92	R:R:M198	R:R:S113	6.13	Yes	No	0	8	9
93	R:R:S113	R:R:Y202	6.36	No	Yes	0	9	9
94	R:R:D115	R:R:Y126	5.75	No	Yes	0	8	7
95	R:R:R116	R:R:Y202	3.09	No	Yes	0	9	9
96	R:R:M121	R:R:Y117	4.79	No	No	6	7	7
97	R:R:T201	R:R:Y117	7.49	No	No	0	7	7
98	R:R:R204	R:R:Y117	6.17	No	No	6	3	7
99	R:R:A119	R:R:Y126	6.67	No	Yes	0	8	7
100	R:R:M121	R:R:R204	3.72	No	No	6	7	3
101	R:R:D122	R:R:P123	3.22	No	No	0	6	8
102	R:R:D122	R:R:R125	17.87	No	No	0	6	5
103	R:R:P127	R:R:Y126	4.17	No	Yes	0	4	7
104	R:R:V130	R:R:Y126	6.31	No	Yes	0	7	7
105	R:R:P132	R:R:T131	3.5	No	No	0	2	8
106	R:R:R134	R:R:T131	6.47	No	No	0	5	8
107	R:R:F151	R:R:I147	2.51	Yes	No	3	3	4
108	R:R:L149	R:R:Y182	4.69	No	Yes	0	5	5
109	R:R:F151	R:R:S150	3.96	Yes	No	3	3	7
110	R:R:S153	R:R:W158	4.94	No	No	0	5	4
111	R:R:S153	R:R:Y182	2.54	No	Yes	0	5	5
112	R:R:H155	R:R:I154	5.3	No	No	0	4	4
113	R:R:I154	R:R:N159	7.08	No	No	0	4	5
114	R:R:N159	R:R:S160	2.98	No	No	7	5	4
115	R:R:N159	R:R:Q177	5.28	No	No	7	5	3
116	R:R:Q177	R:R:S160	11.55	No	No	7	3	4
117	R:R:E163	R:R:N162	7.89	No	No	0	1	4
118	R:R:D262	R:R:E163	14.29	No	No	0	1	1
119	R:R:K175	R:R:R257	6.19	No	No	0	4	4
120	R:R:F254	R:R:V178	5.24	No	No	0	4	1
121	R:R:R257	R:R:V178	3.92	No	No	0	4	1
122	R:R:G258	R:R:V178	5.52	No	No	0	4	1
123	R:R:N179	R:R:Y182	3.49	No	Yes	0	4	5
124	R:R:D186	R:R:Y182	6.9	Yes	Yes	0	4	5
125	R:R:F254	R:R:G183	3.01	No	No	0	4	5
126	R:R:D186	R:R:T190	7.23	Yes	No	0	4	5
127	R:R:D186	R:R:F251	4.78	Yes	Yes	1	4	7
128	R:R:L188	R:R:Y192	3.52	No	Yes	0	5	4
129	R:R:F191	R:R:Y192	5.16	Yes	Yes	1	8	4
130	R:R:F191	R:R:L195	2.44	Yes	No	1	8	7
131	R:R:F191	R:R:F243	6.43	Yes	Yes	1	8	9
132	R:R:F191	R:R:W247	3.01	Yes	Yes	1	8	8
133	R:R:F191	R:R:F248	7.5	Yes	Yes	1	8	5
134	R:R:F191	R:R:F251	11.79	Yes	Yes	1	8	7
135	R:R:F248	R:R:Y192	4.13	Yes	Yes	1	5	4
136	R:R:T252	R:R:Y192	2.5	No	Yes	1	6	4
137	R:R:L193	R:R:P194	3.28	No	No	0	6	8
138	R:R:C199	R:R:L195	3.17	No	No	0	5	7
139	R:R:F243	R:R:L195	4.87	Yes	No	1	9	7
140	R:R:M198	R:R:M240	2.89	Yes	No	0	8	8
141	R:R:F243	R:R:M198	3.73	Yes	Yes	0	9	8
142	R:R:V239	R:R:Y202	2.52	No	Yes	0	8	9
143	R:R:M240	R:R:Y202	4.79	No	Yes	0	8	9
144	R:R:F206	R:R:R210	3.21	Yes	No	0	5	5
145	R:R:F206	R:R:T233	5.19	Yes	No	0	5	6
146	R:R:F206	R:R:L236	2.44	Yes	No	0	5	7
147	R:R:D211	R:R:R215	3.57	No	No	0	4	4
148	R:R:A213	R:R:I227	3.25	No	No	0	4	5
149	R:R:H218	R:R:K214	2.62	No	No	0	3	4
150	R:R:I216	R:R:N217	2.83	No	Yes	0	5	3
151	R:R:I216	R:R:I219	2.94	No	No	0	5	3
152	R:R:A225	R:R:N217	6.25	No	Yes	0	4	3
153	R:R:I227	R:R:N217	14.16	No	Yes	0	5	3
154	R:R:S220	R:R:W222	2.47	No	No	0	6	4
155	R:R:K223	R:R:S220	6.12	No	No	0	4	6
156	R:R:S221	R:R:W222	7.41	No	No	0	5	4
157	R:R:E229	R:R:I227	2.73	No	No	0	7	5
158	R:R:H230	R:R:R228	3.39	No	No	0	5	6
159	R:R:E229	R:R:H230	12.31	No	No	0	7	5
160	R:R:V239	R:R:Y288	2.52	No	No	0	8	9
161	R:R:I244	R:R:M240	5.83	No	No	0	6	8
162	R:R:C246	R:R:N280	12.6	No	Yes	0	9	9
163	R:R:W247	R:R:Y250	4.82	Yes	Yes	1	8	6
164	R:R:F251	R:R:W247	4.01	Yes	Yes	1	7	8
165	R:R:G277	R:R:W247	2.81	No	Yes	0	7	8
166	R:R:N280	R:R:W247	6.78	Yes	Yes	0	9	8
167	R:R:F248	R:R:P249	4.33	Yes	No	0	5	9
168	R:R:F248	R:R:T252	7.78	Yes	No	1	5	6
169	R:R:F251	R:R:Y250	4.13	Yes	Yes	1	7	6
170	R:R:F254	R:R:Y250	5.16	No	Yes	0	4	6
171	R:R:A264	R:R:Y256	5.34	No	No	0	2	4
172	R:R:I265	R:R:Y256	4.84	No	No	0	1	4
173	R:R:I265	R:R:L269	4.28	No	No	0	1	5
174	R:R:N266	R:R:V268	5.91	No	No	0	4	1
175	R:R:L269	R:R:V273	2.98	No	No	0	5	5
176	R:R:L274	R:R:Y278	4.69	No	No	0	5	6
177	R:R:W275	R:R:Y278	5.79	Yes	No	0	5	6
178	R:R:N280	R:R:N284	2.72	Yes	No	0	9	9
179	R:R:D294	R:R:N292	8.08	No	No	0	6	8
180	R:R:R293	R:R:R296	5.33	No	No	0	5	8
181	R:R:T63	R:R:W143	2.43	No	No	0	8	9
182	R:R:N179	R:R:R161	2.41	No	No	0	4	1
183	R:R:L236	R:R:Y202	2.34	No	Yes	0	7	9
184	R:R:E229	R:R:R210	2.33	No	No	0	7	5
185	R:R:L28	R:R:W275	2.28	No	Yes	0	7	5
186	R:R:A34	R:R:G35	1.95	No	No	0	5	8
187	R:R:G35	R:R:V38	1.84	No	No	0	8	7
188	R:R:G68	R:R:T32	1.82	No	No	0	7	8
189	R:R:P285	R:R:V39	1.77	No	Yes	0	9	9
190	R:R:P249	R:R:V273	1.77	No	No	0	9	5
191	R:R:A16	R:R:S14	1.71	No	No	0	5	7
192	R:R:G68	R:R:L67	1.71	No	Yes	0	7	8
193	R:R:G277	R:R:L276	1.71	No	No	0	7	7
194	R:R:A61	R:R:V39	1.7	No	Yes	0	9	9
195	R:R:A289	R:R:V39	1.7	No	Yes	0	7	9
196	R:R:A282	R:R:T32	1.68	No	No	0	7	8
197	R:R:D262	R:R:G261	1.68	No	No	0	1	4
198	R:R:C40	R:R:I62	1.64	No	No	0	7	6
199	R:R:C246	R:R:I245	1.64	No	No	0	9	6
200	R:R:A282	R:R:I31	1.62	No	No	0	7	5
201	R:R:S138	R:R:V135	1.62	No	No	0	6	7
202	R:R:A290	R:R:I286	1.62	No	No	0	6	7
203	R:R:V23	R:R:V27	1.6	No	No	0	5	5
204	R:R:S105	R:R:T63	1.6	No	No	0	9	8
205	R:R:S113	R:R:T201	1.6	No	No	0	9	7
206	R:R:V140	R:R:V144	1.6	No	No	0	3	5
207	R:R:C118	R:R:L129	1.59	No	No	0	5	4
208	R:R:T131	R:R:V133	1.59	No	No	0	8	4
209	R:R:A76	R:R:L25	1.58	No	No	0	6	7
210	R:R:A242	R:R:L283	1.58	No	No	0	6	6
211	R:R:A242	R:R:L287	1.58	No	No	0	6	8
212	R:R:C91	R:R:N92	1.57	No	No	0	9	6
213	R:R:A242	R:R:N280	1.56	No	Yes	0	6	9
214	R:R:I145	R:R:S146	1.55	No	No	0	5	8
215	R:R:I19	R:R:V23	1.54	No	No	0	7	5
216	R:R:I145	R:R:V189	1.54	No	No	0	5	5
217	R:R:A271	R:R:Q79	1.52	No	No	0	4	3
218	R:R:M121	R:R:V120	1.52	No	No	0	7	8
219	R:R:F251	R:R:G187	1.51	Yes	No	0	7	5
220	R:R:G261	R:R:R260	1.5	No	No	0	4	4
221	R:R:L49	R:R:V43	1.49	No	No	0	7	7
222	R:R:L52	R:R:V130	1.49	No	No	0	6	7
223	R:R:L52	R:R:V135	1.49	No	No	0	6	7
224	R:R:L291	R:R:T235	1.47	No	No	0	7	8
225	R:R:I62	R:R:L65	1.43	No	Yes	0	6	7
226	R:R:I93	R:R:L97	1.43	No	No	0	5	5
227	R:R:E180	R:R:V181	1.43	No	No	0	2	4
228	R:R:I57	R:R:N292	1.42	No	No	0	8	8
229	R:R:C55	R:R:R50	1.39	No	No	0	4	7
230	R:R:A232	R:R:F206	1.39	No	Yes	0	7	5
231	R:R:L101	R:R:L66	1.38	No	No	0	7	7
232	R:R:L65	R:R:N36	1.37	Yes	No	0	7	9
233	R:R:E270	R:R:I265	1.37	No	No	0	4	1
234	R:R:N162	R:R:N179	1.36	No	No	0	4	4
235	R:R:C118	R:R:Y126	1.34	No	Yes	0	5	7
236	R:R:F295	R:R:V39	1.31	No	Yes	0	8	9
237	R:R:E267	R:R:N266	1.31	No	No	0	4	4
238	R:R:H155	R:R:L156	1.29	No	No	0	4	3
239	R:R:H218	R:R:N217	1.28	No	Yes	0	3	3
240	R:R:S81	R:R:Y78	1.27	No	No	0	4	4
241	R:R:I200	R:R:R204	1.25	No	No	0	5	3
242	R:R:F110	R:R:M111	1.24	Yes	Yes	0	7	6
243	R:R:F110	R:R:M198	1.24	Yes	Yes	0	7	8
244	R:R:N46	R:R:R50	1.21	No	No	0	5	7
245	R:R:I205	R:R:Y202	1.21	No	Yes	0	8	9
246	R:R:K173	R:R:Y78	1.19	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.415	6	1	0
2	R:R:V39	1.62	4	0	9
3	R:R:F56	4.2	5	5	8
4	R:R:D64	7.4625	4	4	9
5	R:R:L65	2.4825	4	0	7
6	R:R:L67	3.726	5	4	8
7	R:R:W84	6.70571	7	2	8
8	R:R:Y94	4.38	4	0	5
9	R:R:M100	4.255	4	3	5
10	R:R:F110	3.882	5	0	7
11	R:R:M111	3.0525	4	5	6
12	R:R:Y126	4.665	6	0	7
13	R:R:F151	3.584	5	3	3
14	R:R:Y182	4.405	4	0	5
15	R:R:D186	5.365	4	1	4
16	R:R:F191	5.54857	7	1	8
17	R:R:Y192	3.8275	4	1	4
18	R:R:M198	3.4975	4	0	8
19	R:R:Y202	3.385	6	0	9
20	R:R:F206	3.0575	4	0	5
21	R:R:N217	6.13	4	0	3
22	R:R:F243	4.498	5	1	9
23	R:R:W247	4.44167	6	1	8
24	R:R:F248	5.935	4	1	5
25	R:R:Y250	8.7675	4	1	6
26	R:R:F251	4.94333	6	1	7
27	R:R:W275	4.085	4	0	5
28	R:R:N280	5.915	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D98	97.5771	8.94	Yes	No	0	0	5
2	R:R:D98	R:R:Y278	15.9498	4.6	No	No	0	5	6
3	R:R:W275	R:R:Y278	12.4444	5.79	Yes	No	0	5	6
4	R:R:D98	R:R:V71	86.2366	5.84	No	No	0	5	6
5	R:R:L67	R:R:V71	69.9713	2.98	Yes	No	0	8	6
6	R:R:G68	R:R:L67	13.8925	1.71	No	Yes	0	7	8
7	R:R:D64	R:R:L67	55.9283	6.79	Yes	Yes	4	9	8
8	R:R:D64	R:R:N36	41.3118	5.39	Yes	No	0	9	9
9	R:R:L65	R:R:N36	13.8925	1.37	Yes	No	0	7	9
10	R:R:N36	R:R:P285	27.0896	4.89	No	No	0	9	9
11	R:R:P285	R:R:V39	19.6344	1.77	No	Yes	0	9	9
12	R:R:F295	R:R:V39	13.8925	1.31	No	Yes	0	8	9
13	R:R:F295	R:R:V43	11.9498	2.62	No	No	0	8	7
14	L:L:?1	R:R:F251	90.7599	3.44	Yes	Yes	1	0	7
15	R:R:F191	R:R:F251	100	11.79	Yes	Yes	1	8	7
16	R:R:F191	R:R:I106	27.6631	2.51	Yes	No	1	8	7
17	R:R:I106	R:R:L107	27.2401	2.85	No	No	0	7	5
18	R:R:I142	R:R:L107	26.0358	5.71	No	No	0	6	5
19	R:R:I142	R:R:M111	25.5125	2.92	No	Yes	0	6	6
20	R:R:F56	R:R:M111	39.2043	4.98	Yes	Yes	5	8	6
21	R:R:D115	R:R:F56	32.595	7.17	No	Yes	0	8	8
22	R:R:D115	R:R:Y126	30.2079	5.75	No	Yes	0	8	7
23	R:R:T53	R:R:Y126	15.5914	3.75	No	Yes	0	8	7
24	R:R:N51	R:R:T53	13.0394	5.85	No	No	0	7	8
25	R:R:F191	R:R:F243	83.1828	6.43	Yes	Yes	1	8	9
26	R:R:F243	R:R:M198	81.9713	3.73	Yes	Yes	0	9	8
27	R:R:F110	R:R:M198	42.5233	1.24	Yes	Yes	0	7	8
28	R:R:F110	R:R:M111	36.466	1.24	Yes	Yes	0	7	6
29	R:R:N51	R:R:N54	10.4588	10.9	No	No	0	7	8
30	R:R:M111	R:R:S138	19.6487	3.07	Yes	No	5	6	6
31	R:R:S138	R:R:V135	17.8495	1.62	No	No	0	6	7
32	R:R:L52	R:R:V135	15.362	1.49	No	No	0	6	7
33	R:R:L52	R:R:P132	10.8029	8.21	No	No	0	6	2
34	R:R:C102	R:R:W247	10.0717	5.22	No	Yes	0	7	8
35	R:R:N280	R:R:W247	28.5305	6.78	Yes	Yes	0	9	8
36	R:R:N280	R:R:N284	13.0466	2.72	Yes	No	0	9	9
37	R:R:L60	R:R:N284	10.5376	4.12	No	No	0	9	9
38	L:L:?1	R:R:Y250	14.1864	20.96	Yes	Yes	1	0	6
39	R:R:W247	R:R:Y250	15.914	4.82	Yes	Yes	1	8	6
40	R:R:F251	R:R:W247	10.5448	4.01	Yes	Yes	1	7	8
41	R:R:D64	R:R:S105	15.7563	5.89	Yes	No	0	9	9
42	R:R:L101	R:R:L67	10.3799	4.15	No	Yes	0	7	8
43	L:L:?1	R:R:V99	28	5.61	Yes	No	0	0	4
44	R:R:S150	R:R:V99	25.1828	3.23	No	No	0	7	4
45	R:R:F151	R:R:S150	17.4552	3.96	Yes	No	3	3	7
46	R:R:V71	R:R:Y94	32.7312	2.52	No	Yes	0	6	5
47	R:R:W84	R:R:Y94	26.5161	8.68	Yes	Yes	0	8	5
48	R:R:F151	R:R:S96	13.491	5.28	Yes	No	0	3	4
49	R:R:I154	R:R:S96	11.6057	4.64	No	No	0	4	4
50	R:R:S105	R:R:T63	13.828	1.6	No	No	0	9	8
51	R:R:T63	R:R:W143	11.8853	2.43	No	No	0	8	9
52	R:R:M198	R:R:S113	34.4158	6.13	Yes	No	0	8	9
53	R:R:S113	R:R:Y202	26.2366	6.36	No	Yes	0	9	9
54	R:R:M198	R:R:M240	27.8208	2.89	Yes	No	0	8	8
55	R:R:M240	R:R:Y202	25.4839	4.79	No	Yes	0	8	9
56	R:R:D186	R:R:Y182	19.5484	6.9	Yes	Yes	0	4	5
57	R:R:N179	R:R:Y182	12.638	3.49	No	Yes	0	4	5
58	R:R:F254	R:R:Y250	16.2509	5.16	No	Yes	0	4	6
59	R:R:F254	R:R:V178	10.8459	5.24	No	No	0	4	1
60	R:R:F191	R:R:F248	15.8638	7.5	Yes	Yes	1	8	5
61	R:R:L236	R:R:Y202	43.534	2.34	No	Yes	0	7	9
62	R:R:F206	R:R:L236	40.9104	2.44	Yes	No	0	5	7
63	R:R:F206	R:R:R210	32.9534	3.21	Yes	No	0	5	5
64	R:R:E229	R:R:R210	30.2581	2.33	No	No	0	7	5
65	R:R:E229	R:R:I227	22.2867	2.73	No	No	0	7	5
66	R:R:I227	R:R:N217	16.7885	14.16	No	Yes	0	5	3
67	R:R:F248	R:R:P249	12.5376	4.33	Yes	No	0	5	9
68	R:R:P249	R:R:V273	10.7885	1.77	No	No	0	9	5
69	R:R:F191	R:R:W247	14.853	3.01	Yes	Yes	1	8	8
70	R:R:D186	R:R:F251	13.7849	4.78	Yes	Yes	1	4	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D98	8.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:V99	5.61	1	Yes	No	0	4	0	1
L:L:?1	R:R:C102	2.99	1	Yes	No	0	7	0	1
L:L:?1	R:R:D186	2.55	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y250	20.96	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F251	3.44	1	Yes	Yes	0	7	0	1
R:R:D98	R:R:V71	5.84	0	No	No	5	6	1	2
R:R:D98	R:R:Y278	4.6	0	No	No	5	6	1	2
R:R:S150	R:R:V99	3.23	3	No	No	7	4	2	1
R:R:V176	R:R:V99	3.21	0	No	No	5	4	2	1
R:R:C102	R:R:W247	5.22	0	No	Yes	7	8	1	2
R:R:D186	R:R:Y182	6.9	1	Yes	Yes	4	5	1	2
R:R:D186	R:R:T190	7.23	1	Yes	No	4	5	1	2
R:R:D186	R:R:F251	4.78	1	Yes	Yes	4	7	1	1
R:R:F191	R:R:W247	3.01	1	Yes	Yes	8	8	2	2
R:R:F191	R:R:F251	11.79	1	Yes	Yes	8	7	2	1
R:R:W247	R:R:Y250	4.82	1	Yes	Yes	8	6	2	1
R:R:F251	R:R:W247	4.01	1	Yes	Yes	7	8	1	2
R:R:F251	R:R:Y250	4.13	1	Yes	Yes	7	6	1	1
R:R:F254	R:R:Y250	5.16	0	No	Yes	4	6	2	1
R:R:F251	R:R:G187	1.51	1	Yes	No	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8POK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	236
Number of Links	246
Number of Hubs	28
Number of Links mediated by Hubs	111
Number of Communities	7
Number of Nodes involved in Communities	34
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	31337
Length Of Smallest Path	3
Average Path Length	12.1907
Length of Longest Path	28
Minimum Path Strength	1.23
Average Path Strength	4.87155
Maximum Path Strength	15.14
Minimum Path Correlation	0.7
Average Path Correlation	0.933396
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	55.0085
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8326
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• localization • multicellular organismal process • system process • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • regulation of tube diameter • regulation of biological process • regulation of tube size • regulation of system process • biological regulation • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • response to stimulus • immune response • immune system process • trans-synaptic signaling • synaptic signaling • signaling • anterograde trans-synaptic signaling • cell-cell signaling • cellular process • chemical synaptic transmission • cell communication • cellular response to stimulus • regulation of cellular process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • G protein-coupled receptor signaling pathway • signal transduction • cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	4-imidazoleethylamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25021
Sequence	>8POK_nogp_Chain_R D S T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N R R L R N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S C K W S F G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D P L R Y P V L V T P V R V A I S L V L I W V I S I T L S F L S I H L G W N S R N E S K C K V Q V N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I N H I S S W K A A T I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R G D D A I N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D F R T G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YN4	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN4 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN3	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN3 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8WST	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	Pro-MCH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.4	2024-06-19	10.1038/s41421-024-00679-8
	8WST (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	Pro-MCH	-		2.4	2024-06-19	10.1038/s41421-024-00679-8
	8YUT	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-	Gs/β1/γ2	2.7	2024-06-05	10.1002/advs.202310120
	8YUT (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-		2.7	2024-06-05	10.1002/advs.202310120
	8POK	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	3.4	2024-03-06	10.1038/s41467-024-46096-z
	8POK (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		3.4	2024-03-06	10.1038/s41467-024-46096-z
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	7UL3	A	Amine	Histamine	H₂	Homo sapiens	Famotidine	-	-	3	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	10.1002/anie.202200269
	7F16	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-	Gs/β1/γ2	2.8	2021-08-18	10.1073/pnas.2101279118
	7F16 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-		2.8	2021-08-18	10.1073/pnas.2101279118
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	10.1038/nsmb.2965
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	10.1038/nsmb.2965

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8POK_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.