psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D98	11.5	Yes	No	1	0	5
2	L:L:?1	R:R:V99	14.02	Yes	No	0	0	4
3	L:L:?1	R:R:C102	10.46	Yes	No	0	0	7
4	L:L:?1	R:R:D186	7.66	Yes	Yes	1	0	4
5	L:L:?1	R:R:Y250	22.07	Yes	Yes	1	0	6
6	L:L:?1	R:R:F251	4.59	Yes	Yes	0	0	7
7	L:L:?1	R:R:F254	5.73	Yes	Yes	1	0	4
8	L:L:?1	R:R:Y278	4.41	Yes	Yes	1	0	6
9	R:R:L80	R:R:T22	7.37	No	No	0	4	5
10	R:R:L25	R:R:L80	4.15	Yes	No	7	7	4
11	R:R:L25	R:R:W275	10.25	Yes	No	0	7	5
12	R:R:I29	R:R:L72	5.71	No	Yes	0	6	7
13	R:R:L72	R:R:T32	4.42	Yes	No	0	7	8
14	R:R:L69	R:R:V33	4.47	No	No	0	5	6
15	R:R:G35	R:R:P285	4.06	No	No	0	8	9
16	R:R:D64	R:R:N36	6.73	Yes	Yes	0	9	9
17	R:R:N36	R:R:P285	11.4	Yes	No	0	9	9
18	R:R:L65	R:R:V37	4.47	No	No	0	7	4
19	R:R:V38	R:R:Y299	5.05	No	No	0	7	6
20	R:R:V43	R:R:V58	4.81	No	No	0	7	5
21	R:R:L302	R:R:L45	4.15	No	No	0	5	5
22	R:R:L49	R:R:N46	8.24	Yes	No	0	7	5
23	R:R:R47	R:R:R50	13.86	No	No	0	6	7
24	R:R:L49	R:R:R48	6.07	Yes	No	0	7	6
25	R:R:R48	R:R:T297	7.76	No	No	0	6	4
26	R:R:N51	R:R:T53	5.85	No	No	8	7	8
27	R:R:N51	R:R:N54	9.54	No	Yes	8	7	8
28	R:R:L52	R:R:P132	8.21	No	No	0	6	2
29	R:R:L52	R:R:V135	7.45	No	No	0	6	7
30	R:R:N54	R:R:T53	5.85	Yes	No	8	8	8
31	R:R:F295	R:R:N54	13.29	Yes	Yes	0	8	8
32	R:R:F56	R:R:M111	7.46	Yes	No	3	8	6
33	R:R:D115	R:R:F56	5.97	No	Yes	3	8	8
34	R:R:F56	R:R:V135	7.87	Yes	No	0	8	7
35	R:R:F56	R:R:S138	3.96	Yes	No	3	8	6
36	R:R:F56	R:R:L139	4.87	Yes	No	0	8	7
37	R:R:F295	R:R:I57	3.77	Yes	No	0	8	8
38	R:R:N108	R:R:S59	8.94	No	No	0	8	9
39	R:R:L139	R:R:S59	7.51	No	No	0	7	9
40	R:R:D64	R:R:L60	5.43	Yes	Yes	2	9	9
41	R:R:L60	R:R:N108	5.49	Yes	No	0	9	8
42	R:R:L109	R:R:L60	5.54	No	Yes	2	8	9
43	R:R:L60	R:R:N284	10.98	Yes	Yes	2	9	9
44	R:R:T63	R:R:W143	7.28	No	No	0	8	9
45	R:R:D64	R:R:S105	5.89	Yes	No	0	9	9
46	R:R:D64	R:R:S281	11.78	Yes	No	0	9	9
47	R:R:D64	R:R:N284	6.73	Yes	Yes	2	9	9
48	R:R:L101	R:R:L66	4.15	No	No	0	7	7
49	R:R:L67	R:R:V71	5.96	No	No	0	8	6
50	R:R:L101	R:R:L67	5.54	No	No	0	7	8
51	R:R:G68	R:R:L72	5.13	No	Yes	0	7	7
52	R:R:D98	R:R:V71	4.38	No	No	0	5	6
53	R:R:L72	R:R:Y278	8.21	Yes	Yes	0	7	6
54	R:R:F74	R:R:W84	4.01	No	Yes	4	5	8
55	R:R:F74	R:R:F86	6.43	No	Yes	4	5	6
56	R:R:F74	R:R:F90	10.72	No	No	4	5	6
57	R:R:S75	R:R:Y94	6.36	No	No	0	6	5
58	R:R:S75	R:R:Y278	7.63	No	Yes	0	6	6
59	R:R:W84	R:R:Y78	5.79	Yes	No	0	8	4
60	R:R:K173	R:R:Y78	5.97	No	No	0	4	4
61	R:R:A271	R:R:Q79	4.55	No	No	0	4	3
62	R:R:Q79	R:R:W275	4.38	No	No	0	3	5
63	R:R:K83	R:R:S81	4.59	No	No	0	5	4
64	R:R:F86	R:R:W84	10.02	Yes	Yes	4	6	8
65	R:R:F90	R:R:W84	6.01	No	Yes	4	6	8
66	R:R:C91	R:R:W84	5.22	No	Yes	4	9	8
67	R:R:W84	R:R:Y94	9.65	Yes	No	0	8	5
68	R:R:C174	R:R:W84	16.98	No	Yes	4	9	8
69	R:R:F86	R:R:S85	7.93	Yes	No	0	6	3
70	R:R:C91	R:R:K88	6.47	No	No	0	9	3
71	R:R:K88	R:R:N92	5.6	No	No	0	3	6
72	R:R:C174	R:R:C91	7.28	No	No	4	9	9
73	R:R:I154	R:R:N92	4.25	Yes	No	0	4	6
74	R:R:I154	R:R:T95	4.56	Yes	No	0	4	5
75	R:R:F151	R:R:S96	11.89	Yes	No	5	3	4
76	R:R:I154	R:R:S96	7.74	Yes	No	0	4	4
77	R:R:H155	R:R:S96	5.58	No	No	5	4	4
78	R:R:F151	R:R:L97	3.65	Yes	No	0	3	5
79	R:R:D98	R:R:Y278	11.49	No	Yes	1	5	6
80	R:R:M100	R:R:W143	5.82	Yes	No	0	5	9
81	R:R:M100	R:R:S150	6.13	Yes	No	5	5	7
82	R:R:F151	R:R:M100	4.98	Yes	Yes	5	3	5
83	R:R:C102	R:R:W247	5.22	No	Yes	0	7	8
84	R:R:S146	R:R:T103	6.4	No	No	0	8	6
85	R:R:T103	R:R:T190	10.99	No	Yes	0	6	5
86	R:R:A104	R:R:W143	7.78	No	No	0	7	9
87	R:R:I106	R:R:T190	4.56	No	Yes	0	7	5
88	R:R:I106	R:R:W247	14.09	No	Yes	0	7	8
89	R:R:I142	R:R:L107	7.14	No	No	0	6	5
90	R:R:I142	R:R:N108	4.25	No	No	0	6	8
91	R:R:L109	R:R:N284	8.24	No	Yes	2	8	9
92	R:R:L109	R:R:Y288	7.03	No	Yes	2	8	9
93	R:R:F110	R:R:L114	9.74	Yes	No	0	7	6
94	R:R:F110	R:R:P194	5.78	Yes	No	0	7	8
95	R:R:F110	R:R:I197	10.05	Yes	No	0	7	6
96	R:R:F110	R:R:M198	4.98	Yes	Yes	0	7	8
97	R:R:M111	R:R:S138	6.13	No	No	3	6	6
98	R:R:I142	R:R:M111	4.37	No	No	0	6	6
99	R:R:I112	R:R:R116	5.01	No	No	2	9	9
100	R:R:I112	R:R:Y288	7.25	No	Yes	2	9	9
101	R:R:M198	R:R:S113	7.67	Yes	No	0	8	9
102	R:R:S113	R:R:Y202	5.09	No	Yes	0	9	9
103	R:R:D115	R:R:Y126	10.34	No	Yes	3	8	7
104	R:R:D115	R:R:V130	5.84	No	No	3	8	7
105	R:R:R116	R:R:Y288	8.23	No	Yes	2	9	9
106	R:R:M121	R:R:Y117	14.37	No	Yes	0	7	7
107	R:R:T201	R:R:Y117	13.73	No	Yes	0	7	7
108	R:R:R204	R:R:Y117	9.26	No	Yes	0	3	7
109	R:R:I205	R:R:Y117	3.63	No	Yes	0	8	7
110	R:R:A119	R:R:Y126	9.34	No	Yes	0	8	7
111	R:R:I205	R:R:V120	6.14	No	No	0	8	8
112	R:R:D122	R:R:R125	17.87	No	No	0	6	5
113	R:R:P127	R:R:Y126	4.17	No	Yes	0	4	7
114	R:R:V130	R:R:Y126	5.05	No	Yes	3	7	7
115	R:R:P132	R:R:T131	5.25	No	No	0	2	8
116	R:R:R134	R:R:T131	6.47	No	No	0	5	8
117	R:R:F151	R:R:S150	6.61	Yes	No	5	3	7
118	R:R:F151	R:R:H155	6.79	Yes	No	5	3	4
119	R:R:S153	R:R:W158	9.88	No	No	0	5	4
120	R:R:S153	R:R:Y182	6.36	No	Yes	0	5	5
121	R:R:I154	R:R:N159	8.5	Yes	No	0	4	5
122	R:R:L156	R:R:W158	9.11	No	No	0	3	4
123	R:R:G157	R:R:S160	3.71	No	No	0	4	4
124	R:R:N159	R:R:Y182	8.14	No	Yes	0	5	5
125	R:R:G258	R:R:R161	4.5	No	Yes	0	4	1
126	R:R:G261	R:R:R161	4.5	No	Yes	0	4	1
127	R:R:D262	R:R:R161	5.96	No	Yes	0	1	1
128	R:R:K175	R:R:R257	8.66	No	Yes	6	4	4
129	R:R:D262	R:R:K175	6.91	No	No	6	1	4
130	R:R:E270	R:R:K175	10.8	No	No	6	4	4
131	R:R:F254	R:R:V178	14.42	Yes	No	0	4	1
132	R:R:R257	R:R:V178	10.46	Yes	No	0	4	1
133	R:R:G258	R:R:V178	5.52	No	No	0	4	1
134	R:R:D186	R:R:Y182	10.34	Yes	Yes	1	4	5
135	R:R:F254	R:R:Y182	4.13	Yes	Yes	1	4	5
136	R:R:D186	R:R:T190	5.78	Yes	Yes	0	4	5
137	R:R:D186	R:R:F254	5.97	Yes	Yes	1	4	4
138	R:R:L188	R:R:Y192	3.52	No	No	0	5	4
139	R:R:F251	R:R:T190	5.19	Yes	Yes	0	7	5
140	R:R:F191	R:R:Y192	9.28	Yes	No	0	8	4
141	R:R:F191	R:R:L195	8.53	Yes	No	9	8	7
142	R:R:F191	R:R:F243	7.5	Yes	No	9	8	9
143	R:R:F191	R:R:F248	7.5	Yes	No	0	8	5
144	R:R:F191	R:R:F251	17.15	Yes	Yes	0	8	7
145	R:R:T252	R:R:Y192	3.75	No	No	0	6	4
146	R:R:F243	R:R:L195	3.65	No	No	9	9	7
147	R:R:M198	R:R:M240	4.33	Yes	No	0	8	8
148	R:R:F243	R:R:M198	7.46	No	Yes	0	9	8
149	R:R:I200	R:R:R204	5.01	No	No	0	5	3
150	R:R:L236	R:R:Y202	3.52	No	Yes	0	7	9
151	R:R:V239	R:R:Y202	3.79	No	Yes	0	8	9
152	R:R:M240	R:R:Y202	8.38	No	Yes	0	8	9
153	R:R:K207	R:R:Y203	9.55	No	No	0	4	3
154	R:R:F206	R:R:R210	10.69	Yes	No	0	5	5
155	R:R:F206	R:R:T233	6.49	Yes	No	0	5	6
156	R:R:F206	R:R:L236	3.65	Yes	No	0	5	7
157	R:R:D211	R:R:R215	4.76	No	No	0	4	4
158	R:R:Q212	R:R:R215	7.01	No	No	0	6	4
159	R:R:H218	R:R:K214	3.93	No	No	0	3	4
160	R:R:I216	R:R:I227	7.36	No	Yes	10	5	5
161	R:R:A225	R:R:N217	6.25	No	No	0	4	3
162	R:R:I227	R:R:N217	5.66	Yes	No	0	5	3
163	R:R:S220	R:R:W222	18.53	No	No	0	6	4
164	R:R:K223	R:R:S220	4.59	No	No	0	4	6
165	R:R:K223	R:R:T226	4.5	No	No	0	4	3
166	R:R:E229	R:R:H230	9.85	No	No	0	7	5
167	R:R:H230	R:R:T233	9.58	No	No	0	5	6
168	R:R:V239	R:R:Y288	3.79	No	Yes	0	8	9
169	R:R:C246	R:R:N280	7.87	No	No	0	9	9
170	R:R:W247	R:R:Y250	6.75	Yes	Yes	0	8	6
171	R:R:F251	R:R:W247	8.02	Yes	Yes	0	7	8
172	R:R:G277	R:R:W247	8.44	No	Yes	0	7	8
173	R:R:N280	R:R:W247	10.17	No	Yes	0	9	8
174	R:R:F248	R:R:P249	4.33	No	No	0	5	9
175	R:R:F248	R:R:T252	9.08	No	No	0	5	6
176	R:R:P249	R:R:V273	3.53	No	No	0	9	5
177	R:R:F254	R:R:Y250	7.22	Yes	Yes	1	4	6
178	R:R:V273	R:R:Y250	3.79	No	Yes	0	5	6
179	R:R:L274	R:R:Y250	3.52	No	Yes	0	5	6
180	R:R:R260	R:R:Y256	10.29	No	No	0	4	4
181	R:R:I265	R:R:Y256	4.84	Yes	No	0	1	4
182	R:R:D262	R:R:R257	11.91	No	Yes	6	1	4
183	R:R:E270	R:R:R257	9.3	No	Yes	6	4	4
184	R:R:I265	R:R:L269	5.71	Yes	No	0	1	5
185	R:R:E270	R:R:I265	4.1	No	Yes	0	4	1
186	R:R:N266	R:R:V268	4.43	No	No	0	4	1
187	R:R:L274	R:R:Y278	9.38	No	Yes	0	5	6
188	R:R:W275	R:R:Y278	12.54	No	Yes	0	5	6
189	R:R:N280	R:R:N284	9.54	No	Yes	0	9	9
190	R:R:L287	R:R:Y288	3.52	No	Yes	0	8	9
191	R:R:A289	R:R:F295	5.55	No	Yes	0	7	8
192	R:R:D294	R:R:N292	5.39	No	No	0	6	8
193	R:R:F295	R:R:N292	4.83	Yes	No	0	8	8
194	R:R:E180	R:R:R161	3.49	No	Yes	0	2	1
195	R:R:N179	R:R:Y182	3.49	No	Yes	0	4	5
196	R:R:A61	R:R:V39	3.39	No	No	0	9	9
197	R:R:A289	R:R:V39	3.39	No	No	0	7	9
198	R:R:G298	R:R:N46	3.39	No	No	0	5	5
199	R:R:A282	R:R:I31	3.25	No	No	0	7	5
200	R:R:A253	R:R:I265	3.25	No	Yes	0	4	1
201	R:R:V176	R:R:V99	3.21	No	No	0	5	4
202	R:R:V120	R:R:V208	3.21	No	No	0	8	5
203	R:R:R293	R:R:R296	3.2	No	No	0	5	8
204	R:R:T131	R:R:V133	3.17	No	No	0	8	4
205	R:R:C199	R:R:L195	3.17	No	No	0	5	7
206	R:R:A76	R:R:L25	3.15	No	Yes	0	6	7
207	R:R:A61	R:R:N36	3.13	No	Yes	0	9	9
208	R:R:I31	R:R:V27	3.07	No	No	0	5	5
209	R:R:I62	R:R:V58	3.07	No	No	0	6	5
210	R:R:I137	R:R:V133	3.07	No	No	0	4	4
211	R:R:F254	R:R:G183	3.01	Yes	No	0	4	5
212	R:R:F251	R:R:G187	3.01	Yes	No	0	7	5
213	R:R:L65	R:R:V33	2.98	No	No	0	7	6
214	R:R:L41	R:R:V37	2.98	No	No	0	4	4
215	R:R:L49	R:R:V43	2.98	Yes	No	0	7	7
216	R:R:L129	R:R:V128	2.98	No	No	0	4	5
217	R:R:N179	R:R:V181	2.96	No	No	0	4	4
218	R:R:I216	R:R:I219	2.94	No	No	0	5	3
219	R:R:I147	R:R:M100	2.92	No	Yes	0	4	5
220	R:R:I244	R:R:M240	2.92	No	No	0	6	8
221	R:R:I21	R:R:L25	2.85	No	Yes	7	4	7
222	R:R:I21	R:R:L80	2.85	No	No	7	4	4
223	R:R:I145	R:R:L107	2.85	No	No	0	5	5
224	R:R:I137	R:R:L141	2.85	No	No	0	4	4
225	R:R:I145	R:R:L149	2.85	No	No	0	5	5
226	R:R:A42	R:R:F295	2.77	No	Yes	0	8	8
227	R:R:L70	R:R:L97	2.77	No	No	0	5	5
228	R:R:L188	R:R:L193	2.77	No	No	0	5	6
229	R:R:L65	R:R:N36	2.75	No	Yes	0	7	9
230	R:R:L49	R:R:N54	2.75	Yes	Yes	0	7	8
231	R:R:D122	R:R:L129	2.71	No	No	0	6	4
232	R:R:A42	R:R:Y299	2.67	No	No	0	8	6
233	R:R:A264	R:R:Y256	2.67	No	No	0	2	4
234	R:R:E180	R:R:L259	2.65	No	No	0	2	5
235	R:R:H218	R:R:N217	2.55	No	No	0	3	3
236	R:R:K231	R:R:R228	2.48	No	No	0	8	6
237	R:R:L129	R:R:R134	2.43	No	No	0	4	5
238	R:R:I205	R:R:Y202	2.42	No	Yes	0	8	9
239	R:R:F206	R:R:Y203	2.06	Yes	No	0	5	3
240	R:R:A34	R:R:G35	1.95	No	No	0	5	8
241	R:R:G44	R:R:V43	1.84	No	No	0	2	7
242	R:R:G187	R:R:V255	1.84	No	No	0	5	5
243	R:R:A61	R:R:C40	1.81	No	No	0	9	7
244	R:R:A209	R:R:A232	1.79	No	No	0	8	7
245	R:R:C55	R:R:V135	1.71	No	No	0	4	7
246	R:R:G277	R:R:L276	1.71	No	No	0	7	7
247	R:R:A282	R:R:T32	1.68	No	No	0	7	8
248	R:R:D263	R:R:G261	1.68	No	No	0	1	4
249	R:R:L72	R:R:P73	1.64	Yes	No	0	7	8
250	R:R:A213	R:R:I227	1.62	No	Yes	0	4	5
251	R:R:A290	R:R:I286	1.62	No	No	0	6	7
252	R:R:D122	R:R:P123	1.61	No	No	0	6	8
253	R:R:S14	R:R:T15	1.6	No	No	0	7	4
254	R:R:V23	R:R:V27	1.6	No	No	0	5	5
255	R:R:V140	R:R:V144	1.6	No	No	0	3	5
256	R:R:V181	R:R:V185	1.6	No	No	0	4	4
257	R:R:T148	R:R:V144	1.59	No	No	0	4	5
258	R:R:C246	R:R:L283	1.59	No	No	0	9	6
259	R:R:A279	R:R:L28	1.58	No	No	0	5	7
260	R:R:A42	R:R:L302	1.58	No	No	0	8	5
261	R:R:A238	R:R:L287	1.58	No	No	0	6	8
262	R:R:A242	R:R:L283	1.58	No	No	0	6	6
263	R:R:A242	R:R:L287	1.58	No	No	0	6	8
264	R:R:A290	R:R:L291	1.58	No	No	0	6	7
265	R:R:I77	R:R:S81	1.55	No	No	0	4	4
266	R:R:I145	R:R:V189	1.54	No	No	0	5	5
267	R:R:I272	R:R:V268	1.54	No	No	0	5	1
268	R:R:K83	R:R:S172	1.53	No	No	0	5	4
269	R:R:I216	R:R:T226	1.52	No	No	10	5	3
270	R:R:I227	R:R:T226	1.52	Yes	No	10	5	3
271	R:R:F86	R:R:G87	1.51	Yes	No	0	6	8
272	R:R:K18	R:R:T22	1.5	No	No	0	4	5
273	R:R:G44	R:R:R50	1.5	No	No	0	2	7
274	R:R:L184	R:R:V255	1.49	No	No	0	4	5
275	R:R:L28	R:R:T32	1.47	No	No	0	7	8
276	R:R:L152	R:R:T148	1.47	No	No	0	6	4
277	R:R:Q177	R:R:S160	1.44	No	No	0	3	4
278	R:R:I147	R:R:L152	1.43	No	No	0	4	6
279	R:R:I200	R:R:L196	1.43	No	No	0	5	4
280	R:R:Q212	R:R:V208	1.43	No	No	0	6	5
281	R:R:A232	R:R:F206	1.39	No	Yes	0	7	5
282	R:R:L269	R:R:N266	1.37	No	No	0	5	4
283	R:R:C118	R:R:Y126	1.34	No	Yes	0	5	7
284	R:R:N46	R:R:Q301	1.32	No	No	0	5	4
285	R:R:N159	R:R:Q177	1.32	No	No	0	5	3
286	R:R:R228	R:R:V234	1.31	No	No	0	6	7
287	R:R:E267	R:R:N266	1.31	No	No	0	4	4
288	R:R:F90	R:R:I93	1.26	No	No	0	6	5
289	R:R:S221	R:R:W222	1.24	No	No	0	5	4
290	R:R:K231	R:R:R293	1.24	No	No	0	8	5
291	R:R:D294	R:R:R293	1.19	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.055	8	1	0
2	R:R:L25	5.1	4	7	7
3	R:R:N36	6.0025	4	0	9
4	R:R:L49	5.01	4	0	7
5	R:R:N54	7.8575	4	8	8
6	R:R:F56	6.026	5	3	8
7	R:R:L60	6.86	4	2	9
8	R:R:D64	7.312	5	2	9
9	R:R:L72	5.022	5	0	7
10	R:R:W84	8.24	7	4	8
11	R:R:F86	6.4725	4	4	6
12	R:R:M100	4.9625	4	5	5
13	R:R:F110	7.6375	4	0	7
14	R:R:Y117	10.2475	4	0	7
15	R:R:Y126	6.048	5	3	7
16	R:R:F151	6.784	5	5	3
17	R:R:I154	6.2625	4	0	4
18	R:R:R161	4.6125	4	0	1
19	R:R:Y182	6.492	5	1	5
20	R:R:D186	7.4375	4	1	4
21	R:R:T190	6.63	4	0	5
22	R:R:F191	9.992	5	9	8
23	R:R:M198	6.11	4	0	8
24	R:R:Y202	4.64	5	0	9
25	R:R:F206	4.856	5	0	5
26	R:R:I227	4.04	4	10	5
27	R:R:W247	8.78167	6	0	8
28	R:R:Y250	8.67	5	1	6
29	R:R:F251	7.592	5	0	7
30	R:R:F254	6.74667	6	1	4
31	R:R:R257	10.0825	4	6	4
32	R:R:I265	4.475	4	0	1
33	R:R:Y278	8.94333	6	1	6
34	R:R:N284	8.8725	4	2	9
35	R:R:Y288	5.964	5	2	9
36	R:R:F295	6.042	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y278	60.6272	4.41	Yes	Yes	1	0	6
2	R:R:W275	R:R:Y278	21.1115	12.54	No	Yes	0	5	6
3	R:R:L25	R:R:W275	14.1255	10.25	Yes	No	0	7	5
4	R:R:L72	R:R:Y278	26.0259	8.21	Yes	Yes	0	7	6
5	R:R:L72	R:R:T32	16.722	4.42	Yes	No	0	7	8
6	L:L:?1	R:R:C102	18.4042	10.46	Yes	No	0	0	7
7	R:R:C102	R:R:W247	18.4435	5.22	No	Yes	0	7	8
8	R:R:N280	R:R:W247	100	10.17	No	Yes	0	9	8
9	R:R:N280	R:R:N284	96.0891	9.54	No	Yes	0	9	9
10	R:R:D64	R:R:N284	48.4267	6.73	Yes	Yes	2	9	9
11	R:R:D64	R:R:N36	60.17	6.73	Yes	Yes	0	9	9
12	L:L:?1	R:R:Y250	18.7007	22.07	Yes	Yes	1	0	6
13	R:R:W247	R:R:Y250	56.252	6.75	Yes	Yes	0	8	6
14	L:L:?1	R:R:F251	50.3482	4.59	Yes	Yes	0	0	7
15	R:R:F251	R:R:W247	27.4331	8.02	Yes	Yes	0	7	8
16	R:R:A61	R:R:N36	48.3089	3.13	No	Yes	0	9	9
17	R:R:A61	R:R:V39	45.5945	3.39	No	No	0	9	9
18	R:R:A289	R:R:V39	44.2266	3.39	No	No	0	7	9
19	R:R:A289	R:R:F295	42.8515	5.55	No	Yes	0	7	8
20	R:R:F295	R:R:N54	22.9794	13.29	Yes	Yes	0	8	8
21	R:R:L49	R:R:N54	18.5114	2.75	Yes	Yes	0	7	8
22	R:R:L60	R:R:N284	47.3553	10.98	Yes	Yes	2	9	9
23	R:R:L60	R:R:N108	63.1308	5.49	Yes	No	0	9	8
24	R:R:N108	R:R:S59	27.9617	8.94	No	No	0	8	9
25	R:R:L139	R:R:S59	26.801	7.51	No	No	0	7	9
26	R:R:F56	R:R:L139	25.6545	4.87	Yes	No	0	8	7
27	R:R:F56	R:R:V135	34.8405	7.87	Yes	No	0	8	7
28	R:R:L52	R:R:V135	29.9118	7.45	No	No	0	6	7
29	R:R:I142	R:R:N108	34.2048	4.25	No	No	0	6	8
30	R:R:I142	R:R:M111	28.476	4.37	No	No	0	6	6
31	R:R:F56	R:R:M111	26.0688	7.46	Yes	No	3	8	6
32	R:R:L52	R:R:P132	27.4367	8.21	No	No	0	6	2
33	R:R:D115	R:R:F56	15.0827	5.97	No	Yes	3	8	8
34	R:R:L109	R:R:N284	14.0184	8.24	No	Yes	2	8	9
35	L:L:?1	R:R:D186	13.0469	7.66	Yes	Yes	1	0	4
36	R:R:D186	R:R:Y182	18.5721	10.34	Yes	Yes	1	4	5
37	R:R:N159	R:R:Y182	34.7762	8.14	No	Yes	0	5	5
38	R:R:I154	R:R:N159	29.1618	8.5	Yes	No	0	4	5
39	R:R:I154	R:R:S96	23.7294	7.74	Yes	No	0	4	4
40	R:R:F151	R:R:S96	20.6115	11.89	Yes	No	5	3	4
41	R:R:F151	R:R:M100	14.3969	4.98	Yes	Yes	5	3	5
42	L:L:?1	R:R:F254	19.8186	5.73	Yes	Yes	1	0	4
43	R:R:F254	R:R:Y182	26.2259	4.13	Yes	Yes	1	4	5
44	R:R:S75	R:R:Y278	28.9225	7.63	No	Yes	0	6	6
45	R:R:S75	R:R:Y94	26.7795	6.36	No	No	0	6	5
46	R:R:W84	R:R:Y94	24.7616	9.65	Yes	No	0	8	5
47	R:R:F251	R:R:T190	10.8682	5.19	Yes	Yes	0	7	5
48	R:R:L109	R:R:Y288	28.1403	7.03	No	Yes	2	8	9
49	R:R:F191	R:R:F251	45.4909	17.15	Yes	Yes	0	8	7
50	R:R:F191	R:R:F243	38.3871	7.5	Yes	No	9	8	9
51	R:R:F243	R:R:M198	38.0728	7.46	No	Yes	0	9	8
52	R:R:M198	R:R:S113	19.7364	7.67	Yes	No	0	8	9
53	R:R:S113	R:R:Y202	19.6757	5.09	No	Yes	0	9	9
54	R:R:M198	R:R:M240	20.4364	4.33	Yes	No	0	8	8
55	R:R:M240	R:R:Y202	20.315	8.38	No	Yes	0	8	9
56	R:R:D115	R:R:Y126	10.1539	10.34	No	Yes	3	8	7
57	R:R:I205	R:R:Y202	24.1044	2.42	No	Yes	0	8	9
58	R:R:I205	R:R:Y117	12.2326	3.63	No	Yes	0	8	7
59	R:R:I205	R:R:V120	10.1004	6.14	No	No	0	8	8
60	R:R:P132	R:R:T131	24.9545	5.25	No	No	0	2	8
61	R:R:R134	R:R:T131	14.9541	6.47	No	No	0	5	8
62	R:R:L129	R:R:R134	12.4362	2.43	No	No	0	4	5
63	R:R:F254	R:R:V178	20.2614	14.42	Yes	No	0	4	1
64	R:R:R257	R:R:V178	13.5826	10.46	Yes	No	0	4	1
65	R:R:E270	R:R:R257	10.9968	9.3	No	Yes	6	4	4
66	R:R:L236	R:R:Y202	20.2472	3.52	No	Yes	0	7	9
67	R:R:V239	R:R:Y288	22.1436	3.79	No	Yes	0	8	9
68	R:R:V239	R:R:Y202	21.315	3.79	No	Yes	0	8	9
69	R:R:F206	R:R:L236	18.2542	3.65	Yes	No	0	5	7
70	R:R:L274	R:R:Y250	15.5863	3.52	No	Yes	0	5	6
71	R:R:L274	R:R:Y278	14.7577	9.38	No	Yes	0	5	6
72	R:R:E270	R:R:I265	10.2825	4.1	No	Yes	0	4	1
73	R:R:F295	R:R:N292	10.7932	4.83	Yes	No	0	8	8
74	R:R:F254	R:R:Y250	23.4008	7.22	Yes	Yes	1	4	6
75	R:R:D64	R:R:L60	15.5648	5.43	Yes	Yes	2	9	9
76	R:R:L109	R:R:L60	15.3648	5.54	No	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D98	11.5	1	Yes	No	0	5	0	1
L:L:?1	R:R:V99	14.02	1	Yes	No	0	4	0	1
L:L:?1	R:R:C102	10.46	1	Yes	No	0	7	0	1
L:L:?1	R:R:D186	7.66	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y250	22.07	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F251	4.59	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F254	5.73	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y278	4.41	1	Yes	Yes	0	6	0	1
R:R:D98	R:R:V71	4.38	1	No	No	5	6	1	2
R:R:L72	R:R:Y278	8.21	0	Yes	Yes	7	6	2	1
R:R:S75	R:R:Y278	7.63	0	No	Yes	6	6	2	1
R:R:D98	R:R:Y278	11.49	1	No	Yes	5	6	1	1
R:R:C102	R:R:W247	5.22	0	No	Yes	7	8	1	2
R:R:F254	R:R:V178	14.42	1	Yes	No	4	1	1	2
R:R:D186	R:R:Y182	10.34	1	Yes	Yes	4	5	1	2
R:R:F254	R:R:Y182	4.13	1	Yes	Yes	4	5	1	2
R:R:D186	R:R:T190	5.78	1	Yes	Yes	4	5	1	2
R:R:D186	R:R:F254	5.97	1	Yes	Yes	4	4	1	1
R:R:F251	R:R:T190	5.19	0	Yes	Yes	7	5	1	2
R:R:F191	R:R:F251	17.15	9	Yes	Yes	8	7	2	1
R:R:W247	R:R:Y250	6.75	0	Yes	Yes	8	6	2	1
R:R:F251	R:R:W247	8.02	0	Yes	Yes	7	8	1	2
R:R:F254	R:R:Y250	7.22	1	Yes	Yes	4	6	1	1
R:R:V273	R:R:Y250	3.79	0	No	Yes	5	6	2	1
R:R:L274	R:R:Y250	3.52	0	No	Yes	5	6	2	1
R:R:L274	R:R:Y278	9.38	0	No	Yes	5	6	2	1
R:R:W275	R:R:Y278	12.54	0	No	Yes	5	6	2	1
R:R:V176	R:R:V99	3.21	0	No	No	5	4	2	1
R:R:F254	R:R:G183	3.01	1	Yes	No	4	5	1	2
R:R:F251	R:R:G187	3.01	0	Yes	No	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YN3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	263
Number of Links	291
Number of Hubs	36
Number of Links mediated by Hubs	146
Number of Communities	10
Number of Nodes involved in Communities	47
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	60362
Length Of Smallest Path	3
Average Path Length	13.5843
Length of Longest Path	29
Minimum Path Strength	1.215
Average Path Strength	6.75453
Maximum Path Strength	18.045
Minimum Path Correlation	0.7
Average Path Correlation	0.934254
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	53.1594
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.4243
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	1H-Imidazole-4-ethanamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25021
Sequence	>8YN3_nogp_Chain_R S T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N R R L R N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S C K W S F G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D P L R Y P V L V T P V R V A I S L V L I W V I S I T L S F L S I H L G W N S R T S K C K V Q V N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I N H I S S W K A A T I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R G D D A I N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D F R T G Y Q Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9H2X	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR1	Na	-	1.75	2025-06-18	To be published
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YUT	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-	Gs/β1/γ2	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUT (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8POK	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41467-024-46096-z
	8POK (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		3.4	2024-03-06	doi.org/10.1038/s41467-024-46096-z
	8YN3	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN3 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN4	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN4 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	7UL3	A	Amine	Histamine	H₂	Homo sapiens	Famotidine	-	-	3	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8WST	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	Pro-MCH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WST (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	Pro-MCH	-		2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	7F16	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-	Gs/β1/γ2	2.8	2021-08-18	doi.org/10.1073/pnas.2101279118
	7F16 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-		2.8	2021-08-18	doi.org/10.1073/pnas.2101279118
	9IXJ	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	2.92	2025-07-30	To be published
	9IXJ (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.92	2025-07-30	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8YN3_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.