psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D98	10.22	Yes	No	1	0	5
2	L:L:?1	R:R:V99	11.22	Yes	No	0	0	4
3	L:L:?1	R:R:C102	5.97	Yes	No	0	0	7
4	L:L:?1	R:R:D186	5.11	Yes	Yes	1	0	4
5	L:L:?1	R:R:Y250	14.34	Yes	Yes	1	0	6
6	L:L:?1	R:R:F254	4.59	Yes	Yes	1	0	4
7	L:L:?1	R:R:Y278	3.31	Yes	Yes	1	0	6
8	R:R:I21	R:R:L25	2.85	No	Yes	0	4	7
9	R:R:I21	R:R:L80	2.85	No	No	0	4	4
10	R:R:L25	R:R:W275	7.97	Yes	Yes	0	7	5
11	R:R:I31	R:R:V27	3.07	No	No	0	5	5
12	R:R:I29	R:R:L72	2.85	No	Yes	0	6	7
13	R:R:D64	R:R:N36	6.73	Yes	No	0	9	9
14	R:R:L65	R:R:N36	6.87	No	No	0	7	9
15	R:R:N36	R:R:P285	4.89	No	No	0	9	9
16	R:R:A61	R:R:V39	3.39	No	No	0	9	9
17	R:R:G44	R:R:V43	3.68	No	No	0	2	7
18	R:R:V43	R:R:V58	4.81	No	No	0	7	5
19	R:R:F295	R:R:V43	2.62	No	No	0	8	7
20	R:R:L49	R:R:N46	4.12	Yes	No	0	7	5
21	R:R:N51	R:R:T53	5.85	No	No	4	7	8
22	R:R:N51	R:R:N54	14.98	No	Yes	4	7	8
23	R:R:L52	R:R:V130	2.98	No	No	0	6	7
24	R:R:L52	R:R:P132	8.21	No	No	0	6	2
25	R:R:L52	R:R:V135	4.47	No	No	0	6	7
26	R:R:N54	R:R:T53	4.39	Yes	No	4	8	8
27	R:R:D115	R:R:T53	4.34	No	No	0	8	8
28	R:R:F295	R:R:N54	4.83	No	Yes	0	8	8
29	R:R:C55	R:R:F56	2.79	No	No	0	4	8
30	R:R:C55	R:R:V135	3.42	No	No	0	4	7
31	R:R:F56	R:R:M111	4.98	No	No	0	8	6
32	R:R:F56	R:R:I112	3.77	No	Yes	0	8	9
33	R:R:N108	R:R:S59	2.98	No	No	0	8	9
34	R:R:L139	R:R:S59	3	No	No	0	7	9
35	R:R:D64	R:R:L60	2.71	Yes	Yes	2	9	9
36	R:R:L60	R:R:N108	4.12	Yes	No	0	9	8
37	R:R:L109	R:R:L60	2.77	Yes	Yes	2	8	9
38	R:R:L60	R:R:N284	6.87	Yes	Yes	2	9	9
39	R:R:L101	R:R:T63	2.95	No	No	0	7	8
40	R:R:D64	R:R:S105	4.42	Yes	No	0	9	9
41	R:R:D64	R:R:S281	8.83	Yes	No	0	9	9
42	R:R:D64	R:R:N284	6.73	Yes	Yes	2	9	9
43	R:R:L67	R:R:V71	4.47	No	No	0	8	6
44	R:R:L101	R:R:L67	5.54	No	No	0	7	8
45	R:R:G68	R:R:L72	3.42	No	Yes	0	7	7
46	R:R:L70	R:R:L97	4.15	No	No	0	5	5
47	R:R:L97	R:R:V71	2.98	No	No	0	5	6
48	R:R:D98	R:R:V71	4.38	No	No	0	5	6
49	R:R:L72	R:R:Y278	7.03	Yes	Yes	0	7	6
50	R:R:F74	R:R:F90	6.43	No	No	0	5	6
51	R:R:F74	R:R:Y94	3.09	No	No	0	5	5
52	R:R:S75	R:R:Y94	3.82	No	No	0	6	5
53	R:R:S75	R:R:W275	2.47	No	Yes	1	6	5
54	R:R:S75	R:R:Y278	2.54	No	Yes	1	6	6
55	R:R:W84	R:R:Y78	7.72	Yes	No	0	8	4
56	R:R:K83	R:R:S81	3.06	No	No	0	5	4
57	R:R:K83	R:R:S85	3.06	No	No	0	5	3
58	R:R:F86	R:R:W84	4.01	No	Yes	0	6	8
59	R:R:C91	R:R:W84	5.22	No	Yes	5	9	8
60	R:R:C174	R:R:W84	7.84	No	Yes	5	9	8
61	R:R:C174	R:R:C91	7.28	No	No	5	9	9
62	R:R:I154	R:R:T95	4.56	No	No	0	4	5
63	R:R:T95	R:R:V176	3.17	No	No	0	5	5
64	R:R:S150	R:R:S96	3.26	Yes	Yes	3	7	4
65	R:R:F151	R:R:S96	11.89	No	Yes	3	3	4
66	R:R:I154	R:R:S96	7.74	No	Yes	0	4	4
67	R:R:H155	R:R:S96	2.79	No	Yes	3	4	4
68	R:R:D98	R:R:Y278	9.2	No	Yes	1	5	6
69	R:R:S150	R:R:V99	6.46	Yes	No	0	7	4
70	R:R:M100	R:R:W143	5.82	No	No	0	5	9
71	R:R:I147	R:R:M100	2.92	No	No	0	4	5
72	R:R:M100	R:R:S150	3.07	No	Yes	0	5	7
73	R:R:C102	R:R:W247	3.92	No	Yes	0	7	8
74	R:R:S146	R:R:T103	3.2	No	No	0	8	6
75	R:R:T103	R:R:T190	3.14	No	No	0	6	5
76	R:R:A104	R:R:W143	2.59	No	No	0	7	9
77	R:R:F243	R:R:I106	2.51	Yes	No	0	9	7
78	R:R:F251	R:R:I106	2.51	Yes	No	0	7	7
79	R:R:I142	R:R:L107	7.14	No	No	0	6	5
80	R:R:F243	R:R:L109	2.44	Yes	Yes	0	9	8
81	R:R:L109	R:R:N284	2.75	Yes	Yes	2	8	9
82	R:R:L109	R:R:Y288	5.86	Yes	Yes	2	8	9
83	R:R:F110	R:R:L114	4.87	No	No	0	7	6
84	R:R:F110	R:R:P194	2.89	No	No	0	7	8
85	R:R:F110	R:R:I197	7.54	No	No	0	7	6
86	R:R:M111	R:R:S138	3.07	No	No	0	6	6
87	R:R:I142	R:R:M111	2.92	No	No	0	6	6
88	R:R:I112	R:R:R116	3.76	Yes	No	2	9	9
89	R:R:I112	R:R:Y288	3.63	Yes	Yes	2	9	9
90	R:R:M198	R:R:S113	7.67	No	No	0	8	9
91	R:R:S113	R:R:T201	3.2	No	Yes	6	9	7
92	R:R:S113	R:R:Y202	5.09	No	Yes	6	9	9
93	R:R:D115	R:R:Y126	5.75	No	Yes	0	8	7
94	R:R:R116	R:R:Y288	3.09	No	Yes	2	9	9
95	R:R:M121	R:R:Y117	15.57	No	No	0	7	7
96	R:R:T201	R:R:Y117	7.49	Yes	No	0	7	7
97	R:R:R204	R:R:Y117	6.17	No	No	0	3	7
98	R:R:A119	R:R:Y126	6.67	No	Yes	0	8	7
99	R:R:M121	R:R:V208	4.56	No	No	0	7	5
100	R:R:D122	R:R:P123	3.22	No	No	0	6	8
101	R:R:D122	R:R:R125	11.91	No	No	0	6	5
102	R:R:P127	R:R:Y126	4.17	No	Yes	0	4	7
103	R:R:V130	R:R:Y126	5.05	No	Yes	0	7	7
104	R:R:P132	R:R:T131	3.5	No	No	0	2	8
105	R:R:R134	R:R:T131	11.64	No	No	0	5	8
106	R:R:D186	R:R:L149	4.07	Yes	No	0	4	5
107	R:R:F151	R:R:S150	3.96	No	Yes	3	3	7
108	R:R:F151	R:R:H155	3.39	No	No	3	3	4
109	R:R:L152	R:R:L156	2.77	No	No	0	6	3
110	R:R:S153	R:R:W158	3.71	No	No	0	5	4
111	R:R:S153	R:R:Y182	2.54	No	Yes	0	5	5
112	R:R:L156	R:R:W158	7.97	No	No	0	3	4
113	R:R:N159	R:R:Y182	6.98	No	Yes	0	5	5
114	R:R:D262	R:R:R161	3.57	No	No	0	1	1
115	R:R:K175	R:R:R257	4.95	No	Yes	7	4	4
116	R:R:E270	R:R:K175	4.05	No	No	7	4	4
117	R:R:F254	R:R:V178	7.87	Yes	No	0	4	1
118	R:R:R257	R:R:V178	2.62	Yes	No	0	4	1
119	R:R:G258	R:R:V178	3.68	No	No	0	4	1
120	R:R:N179	R:R:Y182	3.49	No	Yes	0	4	5
121	R:R:E180	R:R:L259	2.65	No	No	0	2	5
122	R:R:F254	R:R:G183	3.01	Yes	No	0	4	5
123	R:R:L184	R:R:V255	2.98	No	No	0	4	5
124	R:R:D186	R:R:T190	4.34	Yes	No	0	4	5
125	R:R:D186	R:R:F254	3.58	Yes	Yes	1	4	4
126	R:R:G187	R:R:Y192	2.9	No	No	0	5	4
127	R:R:F191	R:R:F243	8.57	Yes	Yes	0	8	9
128	R:R:F191	R:R:W247	4.01	Yes	Yes	1	8	8
129	R:R:F191	R:R:F248	3.22	Yes	No	0	8	5
130	R:R:F191	R:R:F251	3.22	Yes	Yes	1	8	7
131	R:R:F243	R:R:L195	2.44	Yes	No	0	9	7
132	R:R:I244	R:R:L195	2.85	No	No	0	6	7
133	R:R:M198	R:R:M240	2.89	No	No	0	8	8
134	R:R:I200	R:R:R204	3.76	No	No	0	5	3
135	R:R:T201	R:R:Y202	2.5	Yes	Yes	6	7	9
136	R:R:V239	R:R:Y202	2.52	No	Yes	0	8	9
137	R:R:M240	R:R:Y202	4.79	No	Yes	0	8	9
138	R:R:K207	R:R:Y203	5.97	No	No	0	4	3
139	R:R:F206	R:R:R210	7.48	Yes	No	0	5	5
140	R:R:A232	R:R:F206	2.77	No	Yes	0	7	5
141	R:R:F206	R:R:T233	2.59	Yes	No	0	5	6
142	R:R:R210	R:R:R228	4.26	No	Yes	0	5	6
143	R:R:Q212	R:R:R215	4.67	No	No	0	6	4
144	R:R:A213	R:R:R228	2.77	No	Yes	0	4	6
145	R:R:K214	R:R:R228	13.61	No	Yes	0	4	6
146	R:R:I216	R:R:N217	2.83	No	Yes	0	5	3
147	R:R:A225	R:R:N217	6.25	No	Yes	0	4	3
148	R:R:N217	R:R:T226	7.31	Yes	No	0	3	3
149	R:R:I219	R:R:S220	3.1	No	No	0	3	6
150	R:R:K223	R:R:S220	7.65	No	No	0	4	6
151	R:R:H230	R:R:V234	17.99	No	No	0	5	7
152	R:R:C246	R:R:N280	9.45	No	No	0	9	9
153	R:R:W247	R:R:Y250	4.82	Yes	Yes	1	8	6
154	R:R:F251	R:R:W247	4.01	Yes	Yes	1	7	8
155	R:R:G277	R:R:W247	7.04	No	Yes	0	7	8
156	R:R:N280	R:R:W247	5.65	No	Yes	0	9	8
157	R:R:F248	R:R:T252	5.19	No	No	0	5	6
158	R:R:F251	R:R:Y250	4.13	Yes	Yes	1	7	6
159	R:R:F254	R:R:Y250	3.09	Yes	Yes	1	4	6
160	R:R:R260	R:R:Y256	7.2	No	No	8	4	4
161	R:R:A264	R:R:Y256	4	No	No	8	2	4
162	R:R:D262	R:R:R257	5.96	No	Yes	0	1	4
163	R:R:E270	R:R:R257	3.49	No	Yes	7	4	4
164	R:R:A264	R:R:R260	2.77	No	No	8	2	4
165	R:R:E270	R:R:I265	2.73	No	No	0	4	1
166	R:R:E267	R:R:N266	11.83	No	No	0	4	4
167	R:R:N266	R:R:V268	2.96	No	No	0	4	1
168	R:R:I272	R:R:V268	3.07	No	No	0	5	1
169	R:R:W275	R:R:Y278	4.82	Yes	Yes	1	5	6
170	R:R:N280	R:R:N284	9.54	No	Yes	0	9	9
171	R:R:A289	R:R:F295	2.77	No	No	0	7	8
172	R:R:R293	R:R:R296	5.33	No	No	0	5	8
173	R:R:G298	R:R:T297	3.64	No	No	0	5	4
174	R:R:L49	R:R:R48	2.43	Yes	No	0	7	6
175	R:R:I205	R:R:Y202	2.42	No	Yes	0	8	9
176	R:R:N217	R:R:R228	2.41	Yes	Yes	0	3	6
177	R:R:K173	R:R:Y78	2.39	No	No	0	4	4
178	R:R:L149	R:R:Y182	2.34	No	Yes	0	5	5
179	R:R:L188	R:R:Y192	2.34	No	No	0	5	4
180	R:R:L236	R:R:Y202	2.34	No	Yes	0	7	9
181	R:R:L274	R:R:Y278	2.34	No	Yes	0	5	6
182	R:R:L287	R:R:Y288	2.34	Yes	Yes	0	8	9
183	R:R:L28	R:R:W275	2.28	No	Yes	0	7	5
184	R:R:F191	R:R:Y192	2.06	Yes	No	0	8	4
185	R:R:F90	R:R:W84	2	No	Yes	0	6	8
186	R:R:A34	R:R:G35	1.95	No	No	0	5	8
187	R:R:G157	R:R:S160	1.86	No	No	0	4	4
188	R:R:G68	R:R:T32	1.82	No	No	0	7	8
189	R:R:A61	R:R:C40	1.81	No	No	0	9	7
190	R:R:A209	R:R:A232	1.79	No	No	0	8	7
191	R:R:P285	R:R:V39	1.77	No	No	0	9	9
192	R:R:P249	R:R:V273	1.77	No	No	0	9	5
193	R:R:C17	R:R:S14	1.72	No	No	0	3	7
194	R:R:A16	R:R:S14	1.71	No	No	0	5	7
195	R:R:G298	R:R:L49	1.71	No	Yes	0	5	7
196	R:R:G277	R:R:L276	1.71	No	No	0	7	7
197	R:R:A282	R:R:T32	1.68	No	No	0	7	8
198	R:R:C40	R:R:I62	1.64	No	No	0	7	6
199	R:R:L72	R:R:P73	1.64	Yes	No	0	7	8
200	R:R:L193	R:R:P194	1.64	No	No	0	6	8
201	R:R:A282	R:R:I31	1.62	No	No	0	7	5
202	R:R:C199	R:R:M240	1.62	No	No	0	5	8
203	R:R:V37	R:R:V38	1.6	No	No	0	4	7
204	R:R:V140	R:R:V144	1.6	No	No	0	3	5
205	R:R:V181	R:R:V185	1.6	No	No	0	4	4
206	R:R:V185	R:R:V189	1.6	No	No	0	4	5
207	R:R:T131	R:R:V133	1.59	No	No	0	8	4
208	R:R:T148	R:R:V144	1.59	No	No	0	4	5
209	R:R:A76	R:R:L25	1.58	No	Yes	0	6	7
210	R:R:A238	R:R:L287	1.58	No	Yes	0	6	8
211	R:R:A242	R:R:L283	1.58	No	No	0	6	6
212	R:R:A242	R:R:L287	1.58	No	Yes	0	6	8
213	R:R:A282	R:R:L283	1.58	No	No	0	7	6
214	R:R:I77	R:R:S81	1.55	No	No	0	4	4
215	R:R:I19	R:R:V23	1.54	No	No	0	7	5
216	R:R:I29	R:R:V33	1.54	No	No	0	6	6
217	R:R:I93	R:R:V89	1.54	No	No	0	5	1
218	R:R:I137	R:R:V133	1.54	No	No	0	4	4
219	R:R:A271	R:R:Q79	1.52	No	No	0	4	3
220	R:R:K88	R:R:V89	1.52	No	No	0	3	1
221	R:R:M121	R:R:V120	1.52	No	No	0	7	8
222	R:R:I197	R:R:T201	1.52	No	Yes	0	6	7
223	R:R:G261	R:R:R161	1.5	No	No	0	4	1
224	R:R:L25	R:R:V24	1.49	Yes	No	0	7	5
225	R:R:L287	R:R:V239	1.49	Yes	No	0	8	8
226	R:R:N179	R:R:V181	1.48	No	No	0	4	4
227	R:R:L80	R:R:T22	1.47	No	No	0	4	5
228	R:R:I112	R:R:I57	1.47	Yes	No	0	9	8
229	R:R:L152	R:R:T148	1.47	No	No	0	6	4
230	R:R:L291	R:R:T235	1.47	No	No	0	7	8
231	R:R:N92	R:R:T95	1.46	No	No	0	6	5
232	R:R:I227	R:R:K231	1.45	No	No	0	5	8
233	R:R:F248	R:R:P249	1.44	No	No	0	5	9
234	R:R:I265	R:R:L269	1.43	No	No	0	1	5
235	R:R:L184	R:R:L188	1.38	No	No	0	4	5
236	R:R:L49	R:R:N54	1.37	Yes	Yes	0	7	8
237	R:R:D122	R:R:L129	1.36	No	No	0	6	4
238	R:R:D294	R:R:N292	1.35	No	No	0	6	8
239	R:R:H230	R:R:I227	1.33	No	No	0	5	5
240	R:R:N159	R:R:Q177	1.32	No	No	0	5	3
241	R:R:R125	R:R:V128	1.31	No	No	0	5	5
242	R:R:E180	R:R:N179	1.31	No	No	0	2	4
243	R:R:H218	R:R:N217	1.28	No	Yes	0	3	3
244	R:R:S221	R:R:W222	1.24	No	No	0	5	4
245	R:R:F206	R:R:L236	1.22	Yes	No	0	5	7
246	R:R:N46	R:R:R47	1.21	No	No	0	5	6
247	R:R:E229	R:R:R210	1.16	No	No	0	7	5
248	R:R:Q79	R:R:W275	1.1	No	Yes	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.82286	7	1	0
2	R:R:L25	3.4725	4	0	7
3	R:R:L49	2.4075	4	0	7
4	R:R:N54	6.3925	4	4	8
5	R:R:L60	4.1175	4	2	9
6	R:R:D64	5.884	5	2	9
7	R:R:L72	3.735	4	0	7
8	R:R:W84	5.358	5	5	8
9	R:R:S96	6.42	4	3	4
10	R:R:L109	3.455	4	2	8
11	R:R:I112	3.1575	4	2	9
12	R:R:Y126	5.41	4	0	7
13	R:R:S150	4.1875	4	3	7
14	R:R:Y182	3.8375	4	0	5
15	R:R:D186	4.275	4	1	4
16	R:R:F191	4.216	5	1	8
17	R:R:T201	3.6775	4	6	7
18	R:R:Y202	3.27667	6	6	9
19	R:R:F206	3.515	4	0	5
20	R:R:N217	4.016	5	0	3
21	R:R:R228	5.7625	4	0	6
22	R:R:F243	3.99	4	0	9
23	R:R:W247	4.90833	6	1	8
24	R:R:Y250	6.595	4	1	6
25	R:R:F251	3.4675	4	1	7
26	R:R:F254	4.428	5	1	4
27	R:R:R257	4.255	4	7	4
28	R:R:W275	3.728	5	1	5
29	R:R:Y278	4.87333	6	1	6
30	R:R:N284	6.4725	4	2	9
31	R:R:L287	1.7475	4	0	8
32	R:R:Y288	3.73	4	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y278	23.4604	3.31	Yes	Yes	1	0	6
2	R:R:W275	R:R:Y278	10.8297	4.82	Yes	Yes	1	5	6
3	L:L:?1	R:R:C102	27.7269	5.97	Yes	No	0	0	7
4	R:R:C102	R:R:W247	27.9895	3.92	No	Yes	0	7	8
5	R:R:N280	R:R:W247	37.305	5.65	No	Yes	0	9	8
6	R:R:N280	R:R:N284	36.7798	9.54	No	Yes	0	9	9
7	L:L:?1	R:R:Y250	52.2914	14.34	Yes	Yes	1	0	6
8	R:R:W247	R:R:Y250	43.9352	4.82	Yes	Yes	1	8	6
9	R:R:F191	R:R:W247	35.3889	4.01	Yes	Yes	1	8	8
10	R:R:F191	R:R:F243	51.5061	8.57	Yes	Yes	0	8	9
11	R:R:F243	R:R:L109	67.8056	2.44	Yes	Yes	0	9	8
12	R:R:L109	R:R:Y288	100	5.86	Yes	Yes	2	8	9
13	R:R:I112	R:R:Y288	56.7133	3.63	Yes	Yes	2	9	9
14	R:R:F56	R:R:I112	53.6099	3.77	No	Yes	0	8	9
15	R:R:C55	R:R:F56	45.7817	2.79	No	No	0	4	8
16	R:R:C55	R:R:V135	44.1497	3.42	No	No	0	4	7
17	R:R:L52	R:R:V135	42.5122	4.47	No	No	0	6	7
18	R:R:L52	R:R:V130	32.5695	2.98	No	No	0	6	7
19	R:R:V130	R:R:Y126	30.8946	5.05	No	Yes	0	7	7
20	R:R:D115	R:R:Y126	26.0036	5.75	No	Yes	0	8	7
21	R:R:D115	R:R:T53	24.3072	4.34	No	No	0	8	8
22	R:R:N54	R:R:T53	20.8688	4.39	Yes	No	4	8	8
23	R:R:F251	R:R:Y250	39.7384	4.13	Yes	Yes	1	7	6
24	R:R:F191	R:R:F251	21.2601	3.22	Yes	Yes	1	8	7
25	R:R:F251	R:R:I106	18.7115	2.51	Yes	No	0	7	7
26	R:R:F243	R:R:I106	18.7142	2.51	Yes	No	0	9	7
27	R:R:L109	R:R:N284	31.98	2.75	Yes	Yes	2	8	9
28	R:R:L49	R:R:N54	10.5456	1.37	Yes	Yes	0	7	8
29	L:L:?1	R:R:D98	10.7091	10.22	Yes	No	1	0	5
30	R:R:D98	R:R:V71	10.4331	4.38	No	No	0	5	6
31	R:R:S75	R:R:Y278	10.9128	2.54	No	Yes	1	6	6
32	R:R:S75	R:R:Y94	10.1356	3.82	No	No	0	6	5
33	L:L:?1	R:R:V99	22.517	11.22	Yes	No	0	0	4
34	R:R:S150	R:R:V99	20.9332	6.46	Yes	No	0	7	4
35	L:L:?1	R:R:D186	32.7732	5.11	Yes	Yes	1	0	4
36	R:R:L287	R:R:Y288	49.3756	2.34	Yes	Yes	0	8	9
37	R:R:L287	R:R:V239	48.7967	1.49	Yes	No	0	8	8
38	R:R:V239	R:R:Y202	47.4835	2.52	No	Yes	0	8	9
39	R:R:T201	R:R:Y202	17.4063	2.5	Yes	Yes	6	7	9
40	R:R:D186	R:R:L149	42.9946	4.07	Yes	No	0	4	5
41	R:R:L149	R:R:Y182	40.73	2.34	No	Yes	0	5	5
42	R:R:S153	R:R:Y182	17.9879	2.54	No	Yes	0	5	5
43	R:R:S153	R:R:W158	15.4339	3.71	No	No	0	5	4
44	R:R:L156	R:R:W158	12.8745	7.97	No	No	0	3	4
45	R:R:L152	R:R:L156	10.3098	2.77	No	No	0	6	3
46	R:R:F254	R:R:V178	11.4381	7.87	Yes	No	0	4	1
47	R:R:N179	R:R:Y182	15.4339	3.49	No	Yes	0	4	5
48	R:R:L236	R:R:Y202	21.6005	2.34	No	Yes	0	7	9
49	R:R:F206	R:R:L236	20.1801	1.22	Yes	No	0	5	7
50	R:R:F206	R:R:R210	14.4289	7.48	Yes	No	0	5	5
51	R:R:R210	R:R:R228	11.6096	4.26	No	Yes	0	5	6
52	R:R:D186	R:R:F254	20.1694	3.58	Yes	Yes	1	4	4
53	R:R:F254	R:R:Y250	30.7311	3.09	Yes	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D98	10.22	1	Yes	No	0	5	0	1
L:L:?1	R:R:V99	11.22	1	Yes	No	0	4	0	1
L:L:?1	R:R:C102	5.97	1	Yes	No	0	7	0	1
L:L:?1	R:R:D186	5.11	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y250	14.34	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F254	4.59	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y278	3.31	1	Yes	Yes	0	6	0	1
R:R:D98	R:R:V71	4.38	1	No	No	5	6	1	2
R:R:L72	R:R:Y278	7.03	0	Yes	Yes	7	6	2	1
R:R:S75	R:R:W275	2.47	1	No	Yes	6	5	2	2
R:R:S75	R:R:Y278	2.54	1	No	Yes	6	6	2	1
R:R:D98	R:R:Y278	9.2	1	No	Yes	5	6	1	1
R:R:S150	R:R:V99	6.46	3	Yes	No	7	4	2	1
R:R:C102	R:R:W247	3.92	0	No	Yes	7	8	1	2
R:R:D186	R:R:L149	4.07	1	Yes	No	4	5	1	2
R:R:F254	R:R:V178	7.87	1	Yes	No	4	1	1	2
R:R:F254	R:R:G183	3.01	1	Yes	No	4	5	1	2
R:R:D186	R:R:T190	4.34	1	Yes	No	4	5	1	2
R:R:D186	R:R:F254	3.58	1	Yes	Yes	4	4	1	1
R:R:W247	R:R:Y250	4.82	1	Yes	Yes	8	6	2	1
R:R:F251	R:R:W247	4.01	1	Yes	Yes	7	8	2	2
R:R:F251	R:R:Y250	4.13	1	Yes	Yes	7	6	2	1
R:R:F254	R:R:Y250	3.09	1	Yes	Yes	4	6	1	1
R:R:W275	R:R:Y278	4.82	1	Yes	Yes	5	6	2	1
R:R:L274	R:R:Y278	2.34	0	No	Yes	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IXJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	246
Number of Links	248
Number of Hubs	32
Number of Links mediated by Hubs	115
Number of Communities	8
Number of Nodes involved in Communities	37
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	54701
Length Of Smallest Path	3
Average Path Length	15.1914
Length of Longest Path	30
Minimum Path Strength	1.39
Average Path Strength	4.47522
Maximum Path Strength	12.78
Minimum Path Correlation	0.7
Average Path Correlation	0.933805
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	47.9858
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.7099
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• localization • multicellular organismal process • system process • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • regulation of tube diameter • regulation of biological process • regulation of tube size • regulation of system process • biological regulation • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • response to stimulus • immune response • immune system process • trans-synaptic signaling • synaptic signaling • signaling • anterograde trans-synaptic signaling • cell-cell signaling • cellular process • chemical synaptic transmission • cell communication • cellular response to stimulus • regulation of cellular process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • G protein-coupled receptor signaling pathway • signal transduction • cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	1H-Imidazole-4-ethanamine
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25021
Sequence	>9IXJ_nogp_Chain_R S T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N R R L R N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S C K W S F G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D P L R Y P V L V T P V R V A I S L V L I W V I S I T L S F L S I H L G W N S R S K C K V Q V N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I N H I S S W K A A T I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R G D D A I N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D F R T G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9H2X	A	Nucleotide	Adenosine	A_2A	Homo sapiens	A1IR1	Na	-	1.75	2025-06-18	To be published
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YUT	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-	Gs/β1/γ2	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUT (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Amthamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8POK	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	3.4	2024-03-06	doi.org/10.1038/s41467-024-46096-z
	8POK (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		3.4	2024-03-06	doi.org/10.1038/s41467-024-46096-z
	8YN3	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN3 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.56	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN4	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN4 (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.97	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	7UL3	A	Amine	Histamine	H₂	Homo sapiens	Famotidine	-	-	3	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8WST	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	Pro-MCH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WST (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	Pro-MCH	-		2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	4RWD	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	Na	-	2.7	2015-01-14	doi.org/10.1038/nsmb.2965
	4RWA	A	Peptide	Opioid	δ	Homo sapiens	DIPP-NH2	-	-	3.28	2015-01-14	doi.org/10.1038/nsmb.2965
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	7F16	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-	Gs/β1/γ2	2.8	2021-08-18	doi.org/10.1073/pnas.2101279118
	7F16 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH2	Homo sapiens	TIP39	-		2.8	2021-08-18	doi.org/10.1073/pnas.2101279118
	9IXJ	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-	Gs/β1/γ2	2.92	2025-07-30	To be published
	9IXJ (No Gprot)	A	Amine	Histamine	H₂	Homo sapiens	Histamine	-		2.92	2025-07-30	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9IXJ_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.