psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S9	R:R:T11	4.8	No	No	0	4	4
2	R:R:S12	R:R:S9	3.26	No	No	0	3	4
3	R:R:T11	R:R:Y265	3.75	No	Yes	0	4	4
4	R:R:S12	R:R:Y265	5.09	No	Yes	0	3	4
5	R:R:E19	R:R:Y15	3.37	Yes	Yes	1	5	4
6	R:R:Y15	R:R:Y265	32.76	Yes	Yes	0	4	4
7	R:R:I268	R:R:Y15	12.09	No	Yes	1	5	4
8	R:R:L269	R:R:Y15	5.86	No	Yes	1	5	4
9	R:R:I16	R:R:I70	4.42	No	No	0	5	6
10	R:R:I22	R:R:V18	3.07	No	No	0	7	4
11	R:R:L269	R:R:V18	11.92	No	No	0	5	4
12	R:R:E19	R:R:M66	4.06	Yes	Yes	0	5	6
13	R:R:E19	R:R:L269	5.3	Yes	No	1	5	5
14	R:R:E19	R:R:H272	18.46	Yes	Yes	1	5	7
15	R:R:A273	R:R:I22	4.87	No	No	0	6	7
16	R:R:C25	R:R:M276	8.1	No	No	0	5	6
17	R:R:A26	R:R:S275	3.42	No	No	0	7	9
18	R:R:G29	R:R:V28	3.68	No	No	0	8	4
19	R:R:A55	R:R:N30	4.69	No	Yes	0	9	9
20	R:R:D58	R:R:N30	10.77	Yes	Yes	0	9	9
21	R:R:I59	R:R:N30	5.66	No	Yes	0	7	9
22	R:R:N30	R:R:P279	8.15	Yes	No	0	9	9
23	R:R:A283	R:R:V33	3.39	No	No	6	7	9
24	R:R:F289	R:R:V33	3.93	Yes	No	6	8	9
25	R:R:I34	R:R:V52	3.07	No	No	0	7	5
26	R:R:A55	R:R:I34	3.25	No	No	0	9	7
27	R:R:L39	R:R:W35	20.5	No	No	0	5	4
28	R:R:F289	R:R:V36	11.8	Yes	No	0	8	8
29	R:R:T292	R:R:V36	3.17	No	No	0	7	8
30	R:R:V37	R:R:V52	4.81	No	No	0	8	5
31	R:R:N40	R:R:T292	5.85	No	No	0	5	7
32	R:R:F48	R:R:L43	18.27	Yes	Yes	0	9	8
33	R:R:L43	R:R:T292	4.42	Yes	No	0	8	7
34	R:R:R111	R:R:T46	6.47	No	No	4	8	5
35	R:R:T46	R:R:Y118	6.24	No	Yes	4	5	8
36	R:R:I127	R:R:T46	4.56	No	No	0	6	5
37	R:R:F48	R:R:T47	5.19	Yes	No	0	9	8
38	R:R:Q124	R:R:Y49	3.38	No	No	0	3	4
39	R:R:W128	R:R:Y49	19.29	No	No	0	1	4
40	R:R:D107	R:R:F50	13.14	No	No	0	9	8
41	R:R:F50	R:R:L131	3.65	No	Yes	0	8	7
42	R:R:S100	R:R:S53	3.26	No	No	0	7	9
43	R:R:L131	R:R:S53	9.01	Yes	No	0	7	9
44	R:R:D58	R:R:L54	8.14	Yes	Yes	2	9	9
45	R:R:L54	R:R:S100	6.01	Yes	No	0	9	7
46	R:R:L101	R:R:L54	4.15	No	Yes	2	8	9
47	R:R:I104	R:R:L54	4.28	No	Yes	2	8	9
48	R:R:L54	R:R:N278	6.87	Yes	Yes	2	9	9
49	R:R:A57	R:R:W135	3.89	No	No	0	8	9
50	R:R:D58	R:R:S97	4.42	Yes	No	0	9	9
51	R:R:D58	R:R:N278	8.08	Yes	Yes	2	9	9
52	R:R:A60	R:R:F93	5.55	No	Yes	0	6	6
53	R:R:S97	R:R:V61	3.23	No	No	0	9	8
54	R:R:S275	R:R:V61	4.85	No	No	0	9	8
55	R:R:F93	R:R:L64	4.87	Yes	No	0	6	4
56	R:R:F93	R:R:V65	3.93	Yes	No	0	6	7
57	R:R:H272	R:R:V65	4.15	Yes	No	0	7	7
58	R:R:M66	R:R:P67	11.74	Yes	No	0	6	8
59	R:R:L68	R:R:M86	5.65	No	Yes	0	5	6
60	R:R:I72	R:R:M86	7.29	No	Yes	0	5	6
61	R:R:L74	R:R:S73	4.5	No	No	0	4	5
62	R:R:G75	R:R:R167	4.5	No	No	0	5	5
63	R:R:I78	R:R:V76	3.07	Yes	No	0	5	2
64	R:R:P165	R:R:T77	3.5	No	No	0	5	3
65	R:R:I78	R:R:S82	3.1	Yes	No	0	5	5
66	R:R:C83	R:R:I78	3.27	No	Yes	8	9	5
67	R:R:C166	R:R:I78	6.55	No	Yes	8	9	5
68	R:R:H79	R:R:Y81	3.27	No	No	0	7	1
69	R:R:H79	R:R:T162	4.11	No	No	9	7	3
70	R:R:F163	R:R:H79	7.92	No	No	9	2	7
71	R:R:F80	R:R:Y81	11.35	Yes	No	0	3	1
72	R:R:F80	R:R:L84	3.65	Yes	No	5	3	6
73	R:R:F80	R:R:N150	7.25	Yes	Yes	5	3	5
74	R:R:F80	R:R:K152	4.96	Yes	No	5	3	4
75	R:R:F80	R:R:V171	7.87	Yes	Yes	0	3	5
76	R:R:C166	R:R:C83	7.28	No	No	8	9	9
77	R:R:C83	R:R:V171	6.83	No	Yes	0	9	5
78	R:R:L84	R:R:N150	5.49	No	Yes	5	6	5
79	R:R:F85	R:R:L89	10.96	No	No	0	5	5
80	R:R:F85	R:R:M146	4.98	No	Yes	0	5	5
81	R:R:F168	R:R:T87	6.49	Yes	No	1	5	4
82	R:R:T87	R:R:V171	3.17	No	Yes	0	4	5
83	R:R:M172	R:R:T87	12.04	Yes	No	1	4	4
84	R:R:C88	R:R:P145	5.65	No	Yes	0	6	5
85	R:R:C88	R:R:M146	4.86	No	Yes	0	6	5
86	R:R:I92	R:R:L89	4.28	Yes	No	7	5	5
87	R:R:F93	R:R:L89	6.09	Yes	No	7	6	5
88	R:R:H95	R:R:L91	3.86	Yes	Yes	1	6	4
89	R:R:L91	R:R:M172	4.24	Yes	Yes	1	4	4
90	R:R:L91	R:R:Y176	5.86	Yes	Yes	1	4	6
91	R:R:L91	R:R:M177	5.65	Yes	Yes	1	4	5
92	R:R:F93	R:R:I92	12.56	Yes	Yes	7	6	5
93	R:R:F139	R:R:I92	3.77	No	Yes	0	4	5
94	R:R:G142	R:R:I92	3.53	No	Yes	0	7	5
95	R:R:H95	R:R:T94	4.11	Yes	No	0	6	6
96	R:R:T94	R:R:W243	4.85	No	Yes	0	6	8
97	L:L:?1	R:R:T94	4.87	Yes	No	0	0	6
98	R:R:H95	R:R:V141	6.92	Yes	Yes	1	6	4
99	R:R:H95	R:R:S181	8.37	Yes	No	0	6	5
100	R:R:H95	R:R:W185	5.29	Yes	Yes	1	6	5
101	R:R:A96	R:R:W135	7.78	No	No	0	7	9
102	R:R:A96	R:R:S138	3.42	No	No	0	7	8
103	R:R:I98	R:R:P189	3.39	No	No	0	8	8
104	R:R:F239	R:R:I98	5.02	No	No	3	8	8
105	R:R:I98	R:R:W243	14.09	No	Yes	3	8	8
106	R:R:L102	R:R:M99	5.65	No	No	0	7	5
107	R:R:C134	R:R:M99	4.86	No	No	0	7	5
108	R:R:M99	R:R:S138	3.07	No	No	0	5	8
109	R:R:L101	R:R:N278	12.36	No	Yes	2	8	9
110	R:R:L101	R:R:Y282	4.69	No	Yes	2	8	9
111	R:R:L102	R:R:V192	7.45	No	No	0	7	6
112	R:R:I104	R:R:R108	3.76	No	No	2	8	9
113	R:R:I104	R:R:Y282	7.25	No	Yes	2	8	9
114	R:R:A105	R:R:M193	3.22	No	No	0	8	8
115	R:R:A105	R:R:Y197	4	No	Yes	0	8	9
116	R:R:D107	R:R:R111	11.91	No	No	4	9	8
117	R:R:D107	R:R:Y118	5.75	No	Yes	4	9	8
118	R:R:R108	R:R:Y197	4.12	No	Yes	2	9	9
119	R:R:R108	R:R:Y282	9.26	No	Yes	2	9	9
120	R:R:K113	R:R:Y109	8.36	No	Yes	0	6	8
121	R:R:I196	R:R:Y109	4.84	No	Yes	0	6	8
122	R:R:D199	R:R:Y109	9.2	No	Yes	0	4	8
123	R:R:I200	R:R:Y109	3.63	No	Yes	0	9	8
124	R:R:L110	R:R:L114	4.15	No	No	0	5	5
125	R:R:R111	R:R:Y118	29.84	No	Yes	4	8	8
126	R:R:I200	R:R:V112	4.61	No	No	0	9	9
127	R:R:I203	R:R:V112	4.61	No	No	0	5	9
128	R:R:I203	R:R:K113	5.82	No	No	0	5	6
129	R:R:L114	R:R:Y118	3.52	No	Yes	0	5	8
130	R:R:T115	R:R:V116	3.17	No	No	0	8	6
131	R:R:T122	R:R:Y118	3.75	No	Yes	0	6	8
132	R:R:R126	R:R:T123	3.88	No	No	0	5	8
133	R:R:L131	R:R:W128	4.56	Yes	No	0	7	1
134	R:R:V137	R:R:W185	4.9	No	Yes	0	4	5
135	R:R:G142	R:R:V141	3.68	No	Yes	0	7	4
136	R:R:F180	R:R:V141	6.55	No	Yes	1	5	4
137	R:R:V141	R:R:W185	12.26	Yes	Yes	1	4	5
138	R:R:P145	R:R:T144	3.5	Yes	No	0	5	5
139	R:R:M172	R:R:P145	3.35	Yes	Yes	0	4	5
140	R:R:P145	R:R:Y176	11.13	Yes	Yes	0	5	6
141	R:R:K152	R:R:N150	4.2	No	Yes	5	4	5
142	R:R:M151	R:R:R173	3.72	No	No	0	4	4
143	R:R:R173	R:R:S154	5.27	No	No	0	4	2
144	R:R:L161	R:R:L164	6.92	No	No	0	3	4
145	R:R:F163	R:R:T162	3.89	No	No	9	2	3
146	R:R:L164	R:R:P165	4.93	No	No	0	4	5
147	R:R:R167	R:R:S170	3.95	No	No	0	5	4
148	R:R:F168	R:R:M172	13.68	Yes	Yes	1	5	4
149	R:R:F168	R:R:M177	7.46	Yes	Yes	1	5	5
150	L:L:?1	R:R:F168	32.16	Yes	Yes	1	0	5
151	R:R:M174	R:R:R169	6.2	No	No	0	3	4
152	R:R:L253	R:R:R169	6.07	No	No	0	4	4
153	R:R:D175	R:R:R173	17.87	No	No	0	4	4
154	R:R:M174	R:R:M177	4.33	No	Yes	0	3	5
155	R:R:M177	R:R:Y176	5.99	Yes	Yes	1	5	6
156	R:R:F180	R:R:Y176	10.32	No	Yes	1	5	6
157	L:L:?1	R:R:M177	4.67	Yes	Yes	1	0	5
158	R:R:C251	R:R:V178	3.42	No	No	0	5	5
159	R:R:V178	R:R:Y254	3.79	No	Yes	0	5	4
160	R:R:Y179	R:R:Y254	11.91	No	Yes	0	3	4
161	R:R:F180	R:R:W185	4.01	No	Yes	1	5	5
162	R:R:I186	R:R:S181	3.1	Yes	No	0	7	5
163	R:R:F182	R:R:I186	3.77	No	Yes	3	5	7
164	R:R:F182	R:R:L187	9.74	No	No	0	5	4
165	R:R:F182	R:R:S247	17.18	No	No	3	5	6
166	R:R:F183	R:R:L184	4.87	No	No	0	4	3
167	R:R:L184	R:R:W185	5.69	No	Yes	0	3	5
168	R:R:I186	R:R:W243	8.22	Yes	Yes	3	7	8
169	R:R:I186	R:R:S247	3.1	Yes	No	3	7	6
170	R:R:P189	R:R:V188	3.53	No	No	0	8	4
171	R:R:F239	R:R:L190	9.74	No	No	0	8	6
172	R:R:A240	R:R:L190	3.15	No	No	0	6	6
173	R:R:I196	R:R:V192	3.07	No	No	0	6	6
174	R:R:C194	R:R:L236	6.35	No	No	0	4	7
175	R:R:L232	R:R:Y197	12.89	No	Yes	0	8	9
176	R:R:V235	R:R:Y197	5.05	No	Yes	2	8	9
177	R:R:L236	R:R:Y197	5.86	No	Yes	0	7	9
178	R:R:Y197	R:R:Y282	4.96	Yes	Yes	2	9	9
179	R:R:D199	R:R:I203	4.2	No	No	0	4	5
180	R:R:E225	R:R:F201	4.66	No	No	0	7	5
181	R:R:A229	R:R:F201	4.16	No	No	0	7	5
182	R:R:R205	R:R:Y202	4.12	No	No	0	5	3
183	R:R:I204	R:R:T228	6.08	No	No	0	8	7
184	R:R:E225	R:R:R205	6.98	No	No	0	7	5
185	R:R:K285	R:R:S231	7.65	No	No	0	7	8
186	R:R:L234	R:R:V281	5.96	No	No	0	6	8
187	R:R:V235	R:R:V281	3.21	No	No	0	8	8
188	R:R:V235	R:R:Y282	10.09	No	Yes	2	8	9
189	R:R:F237	R:R:L241	8.53	No	No	0	4	5
190	R:R:L238	R:R:M277	5.65	No	No	0	6	6
191	R:R:F239	R:R:W243	10.02	No	Yes	3	8	8
192	R:R:C242	R:R:N274	6.3	No	No	0	8	9
193	R:R:S271	R:R:W243	12.36	No	Yes	0	7	8
194	R:R:N274	R:R:W243	5.65	No	Yes	0	9	8
195	R:R:L270	R:R:P245	3.28	No	No	0	7	9
196	R:R:G267	R:R:L246	3.42	No	No	0	6	6
197	L:L:?1	R:R:L246	4.57	Yes	No	0	0	6
198	R:R:I249	R:R:V263	4.61	No	No	0	5	4
199	L:L:?1	R:R:N250	9.97	Yes	No	0	0	5
200	R:R:I252	R:R:V259	3.07	No	Yes	0	4	4
201	R:R:F255	R:R:Y254	13.41	No	Yes	0	4	4
202	R:R:P260	R:R:V259	3.53	No	Yes	10	4	4
203	R:R:V259	R:R:V263	4.81	Yes	No	10	4	4
204	R:R:P260	R:R:V263	3.53	No	No	10	4	4
205	R:R:L264	R:R:Q261	6.65	No	No	0	4	2
206	R:R:Q261	R:R:Y265	18.04	No	Yes	0	2	4
207	L:L:?1	R:R:L264	4.57	Yes	No	0	0	4
208	R:R:L266	R:R:L270	4.15	No	No	0	4	7
209	R:R:H272	R:R:I268	6.63	Yes	No	1	7	5
210	L:L:?1	R:R:I268	6.6	Yes	No	1	0	5
211	L:L:?1	R:R:H272	6.79	Yes	Yes	1	0	7
212	R:R:N274	R:R:N278	9.54	No	Yes	0	9	9
213	R:R:A283	R:R:F289	5.55	No	Yes	6	7	8
214	R:R:K290	R:R:Y284	13.14	No	No	0	8	5
215	R:R:E291	R:R:K287	5.4	No	No	0	5	5
216	R:R:M90	R:R:V65	3.04	No	No	0	6	7
217	R:R:F139	R:R:W135	3.01	No	No	0	4	9
218	R:R:L43	R:R:S42	3	Yes	No	0	8	5
219	R:R:L32	R:R:V28	2.98	No	No	0	6	4
220	R:R:L64	R:R:V63	2.98	No	No	0	4	4
221	R:R:L102	R:R:V106	2.98	No	No	0	7	6
222	R:R:L110	R:R:V106	2.98	No	No	0	5	6
223	R:R:L114	R:R:V121	2.98	No	No	0	5	4
224	R:R:L238	R:R:V281	2.98	No	No	0	6	8
225	R:R:L253	R:R:V259	2.98	No	Yes	0	4	4
226	R:R:L21	R:R:T17	2.95	No	No	0	4	6
227	R:R:L140	R:R:T144	2.95	No	No	0	4	5
228	R:R:L232	R:R:T228	2.95	No	No	0	8	7
229	R:R:I20	R:R:M66	2.92	No	Yes	0	4	6
230	R:R:I72	R:R:M90	2.92	No	No	0	5	6
231	R:R:I78	R:R:M86	2.92	Yes	Yes	0	5	6
232	R:R:M276	R:R:M277	2.89	No	No	0	6	6
233	R:R:I34	R:R:L56	2.85	No	No	0	7	6
234	R:R:I204	R:R:L208	2.85	No	No	0	8	4
235	R:R:L24	R:R:M66	2.83	No	Yes	0	4	6
236	R:R:L143	R:R:M146	2.83	No	Yes	0	4	5
237	R:R:K288	R:R:L43	2.82	No	Yes	0	6	8
238	R:R:A103	R:R:F50	2.77	No	No	0	6	8
239	R:R:L190	R:R:L244	2.77	No	No	0	6	6
240	R:R:F48	R:R:V37	2.62	Yes	No	0	9	8
241	R:R:F48	R:R:T45	2.59	Yes	No	0	9	7
242	R:R:F48	R:R:I51	2.51	Yes	No	0	9	8
243	R:R:F48	R:R:I286	2.51	Yes	No	0	9	8
244	R:R:F289	R:R:I286	2.51	Yes	No	0	8	8
245	R:R:F147	R:R:M146	2.49	No	Yes	0	5	5
246	R:R:F80	R:R:L164	2.44	Yes	No	0	3	4
247	R:R:T144	R:R:W149	2.43	No	No	0	5	6
248	R:R:M174	R:R:Y254	2.39	No	Yes	0	3	4
249	R:R:L294	R:R:Y293	2.34	No	No	0	4	7
250	R:R:D175	R:R:Y254	2.3	No	Yes	0	4	4
251	R:R:F289	R:R:Y293	2.06	Yes	No	0	8	7
252	R:R:G267	R:R:P245	2.03	No	No	0	6	9
253	R:R:G62	R:R:S275	1.86	No	No	0	6	9
254	R:R:G257	R:R:I252	1.76	No	No	0	1	4
255	R:R:G23	R:R:M66	1.75	No	Yes	0	6	6
256	R:R:G132	R:R:L131	1.71	No	Yes	0	4	7
257	R:R:G148	R:R:N150	1.7	No	Yes	0	6	5
258	R:R:I280	R:R:P279	1.69	No	No	0	6	9
259	R:R:N40	R:R:P41	1.63	No	No	0	5	6
260	R:R:S170	R:R:V171	1.62	No	Yes	0	4	5
261	R:R:A69	R:R:M90	1.61	No	No	0	6	6
262	R:R:T17	R:R:V13	1.59	No	No	0	6	3
263	R:R:T14	R:R:V18	1.59	No	No	0	4	4
264	R:R:T11	R:R:T262	1.57	No	No	0	4	2
265	R:R:I27	R:R:V31	1.54	No	No	0	6	4
266	R:R:I296	R:R:V36	1.54	No	No	0	5	8
267	R:R:M151	R:R:S155	1.53	No	No	0	4	3
268	R:R:K38	R:R:V37	1.52	No	No	0	1	8
269	R:R:M86	R:R:V71	1.52	Yes	No	0	6	4
270	R:R:L74	R:R:V76	1.49	No	No	0	4	2
271	R:R:L133	R:R:V137	1.49	No	No	0	3	4
272	R:R:I248	R:R:I252	1.47	No	No	0	5	4
273	R:R:I70	R:R:M66	1.46	No	Yes	0	6	6
274	R:R:I20	R:R:L21	1.43	No	No	0	4	4
275	R:R:I296	R:R:L39	1.43	No	No	0	5	5
276	R:R:K285	R:R:L234	1.41	No	No	0	7	6
277	R:R:L153	R:R:N150	1.37	No	Yes	0	3	5
278	R:R:E225	R:R:I204	1.37	No	No	0	7	8
279	R:R:E159	R:R:K152	1.35	No	No	0	2	4
280	R:R:R117	R:R:V116	1.31	No	No	0	5	6
281	R:R:R117	R:R:V121	1.31	No	No	0	5	4
282	R:R:R126	R:R:V121	1.31	No	No	0	5	4
283	R:R:E159	R:R:N160	1.31	No	No	0	2	4
284	R:R:N206	R:R:Y202	1.16	No	No	0	4	3
285	R:R:R119	R:R:Y118	1.03	No	Yes	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y15	13.52	4	1	4
2	R:R:E19	7.7975	4	1	5
3	R:R:N30	7.3175	4	0	9
4	R:R:L43	7.1275	4	0	8
5	R:R:F48	5.615	6	0	9
6	R:R:L54	5.89	5	2	9
7	R:R:D58	7.8525	4	2	9
8	R:R:M66	4.12667	6	0	6
9	R:R:I78	3.782	5	8	5
10	R:R:F80	6.25333	6	5	3
11	R:R:M86	4.345	4	0	6
12	R:R:L91	4.9025	4	1	4
13	R:R:I92	6.035	4	7	5
14	R:R:F93	6.6	5	7	6
15	R:R:H95	5.71	5	1	6
16	R:R:Y109	6.5075	4	0	8
17	R:R:Y118	8.355	6	4	8
18	R:R:L131	4.7325	4	0	7
19	R:R:V141	7.3525	4	1	4
20	R:R:P145	5.9075	4	0	5
21	R:R:M146	3.79	4	0	5
22	R:R:N150	4.002	5	5	5
23	R:R:F168	14.9475	4	1	5
24	R:R:V171	4.8725	4	0	5
25	R:R:M172	8.3275	4	1	4
26	R:R:Y176	8.325	4	1	6
27	R:R:M177	5.62	5	1	5
28	R:R:W185	6.43	5	1	5
29	R:R:I186	4.5475	4	3	7
30	R:R:Y197	6.14667	6	2	9
31	R:R:W243	9.19833	6	3	8
32	R:R:Y254	6.76	5	0	4
33	R:R:V259	3.5975	4	10	4
34	R:R:Y265	14.91	4	0	4
35	R:R:H272	9.0075	4	1	7
36	R:R:N278	9.2125	4	2	9
37	R:R:Y282	7.25	5	2	9
38	R:R:F289	5.17	5	6	8
39	L:L:?1	9.275	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y15	R:R:Y265	11.4349	32.76	Yes	Yes	0	4	4
2	R:R:I268	R:R:Y15	15.6239	12.09	No	Yes	1	5	4
3	R:R:E19	R:R:M66	14.7122	4.06	Yes	Yes	0	5	6
4	R:R:L269	R:R:V18	10.3146	11.92	No	No	0	5	4
5	R:R:E19	R:R:H272	24.1688	18.46	Yes	Yes	1	5	7
6	R:R:V235	R:R:V281	19.1098	3.21	No	No	0	8	8
7	R:R:V235	R:R:Y282	20.3432	10.09	No	Yes	2	8	9
8	R:R:L101	R:R:Y282	44.7563	4.69	No	Yes	2	8	9
9	R:R:L101	R:R:N278	34.3404	12.36	No	Yes	2	8	9
10	R:R:N274	R:R:N278	95.2866	9.54	No	Yes	0	9	9
11	R:R:N274	R:R:W243	96.2639	5.65	No	Yes	0	9	8
12	R:R:T94	R:R:W243	100	4.85	No	Yes	0	6	8
13	L:L:?1	R:R:T94	81.1167	4.87	Yes	No	0	0	6
14	L:L:?1	R:R:I268	14.6407	6.6	Yes	No	1	0	5
15	R:R:D58	R:R:S97	10.4219	4.42	Yes	No	0	9	9
16	R:R:D58	R:R:N278	48.4984	8.08	Yes	Yes	2	9	9
17	R:R:A55	R:R:N30	56.6321	4.69	No	Yes	0	9	9
18	R:R:D58	R:R:N30	63.5681	10.77	Yes	Yes	0	9	9
19	R:R:F289	R:R:I286	17.7988	2.51	Yes	No	0	8	8
20	R:R:F48	R:R:I286	19.4494	2.51	Yes	No	0	9	8
21	R:R:F48	R:R:V37	46.1387	2.62	Yes	No	0	9	8
22	R:R:V37	R:R:V52	49.7855	4.81	No	No	0	8	5
23	R:R:I34	R:R:V52	51.5791	3.07	No	No	0	7	5
24	R:R:A55	R:R:I34	54.8564	3.25	No	No	0	9	7
25	R:R:I296	R:R:V36	11.8877	1.54	No	No	0	5	8
26	R:R:L43	R:R:T292	13.8899	4.42	Yes	No	0	8	7
27	R:R:F48	R:R:L43	19.4852	18.27	Yes	Yes	0	9	8
28	R:R:D107	R:R:F50	32.3442	13.14	No	No	0	9	8
29	R:R:F50	R:R:L131	35.4308	3.65	No	Yes	0	8	7
30	R:R:L131	R:R:S53	42.9627	9.01	Yes	No	0	7	9
31	R:R:S100	R:R:S53	44.4524	3.26	No	No	0	7	9
32	R:R:L54	R:R:S100	45.9361	6.01	Yes	No	0	9	7
33	R:R:L54	R:R:N278	24.0972	6.87	Yes	Yes	2	9	9
34	R:R:D107	R:R:Y118	26.4867	5.75	No	Yes	4	9	8
35	R:R:I104	R:R:L54	21.5529	4.28	No	Yes	2	8	9
36	R:R:F139	R:R:W135	27.7976	3.01	No	No	0	4	9
37	R:R:F139	R:R:I92	29.2754	3.77	No	Yes	0	4	5
38	R:R:F93	R:R:I92	15.32	12.56	Yes	Yes	7	6	5
39	R:R:F93	R:R:V65	21.5469	3.93	Yes	No	0	6	7
40	R:R:H272	R:R:V65	26.2603	4.15	Yes	No	0	7	7
41	R:R:M90	R:R:V65	10.3027	3.04	No	No	0	6	7
42	R:R:T87	R:R:V171	38.6366	3.17	No	Yes	0	4	5
43	R:R:F168	R:R:T87	32.3203	6.49	Yes	No	1	5	4
44	L:L:?1	R:R:F168	36.1697	32.16	Yes	Yes	1	0	5
45	R:R:F80	R:R:V171	25.8908	7.87	Yes	Yes	0	3	5
46	R:R:C88	R:R:M146	10.2729	4.86	No	Yes	0	6	5
47	R:R:C88	R:R:P145	13.2523	5.65	No	Yes	0	6	5
48	R:R:M172	R:R:P145	13.3417	3.35	Yes	Yes	0	4	5
49	R:R:P145	R:R:Y176	13.735	11.13	Yes	Yes	0	5	6
50	R:R:M177	R:R:Y176	12.6385	5.99	Yes	Yes	1	5	6
51	L:L:?1	R:R:M177	30.8962	4.67	Yes	Yes	1	0	5
52	R:R:H95	R:R:T94	24.425	4.11	Yes	No	0	6	6
53	R:R:G142	R:R:I92	16.756	3.53	No	Yes	0	7	5
54	R:R:G142	R:R:V141	17.4532	3.68	No	Yes	0	7	4
55	R:R:H95	R:R:V141	14.0686	6.92	Yes	Yes	1	6	4
56	R:R:A96	R:R:W135	24.8778	7.78	No	No	0	7	9
57	R:R:A96	R:R:S138	23.412	3.42	No	No	0	7	8
58	R:R:L102	R:R:M99	21.1238	5.65	No	No	0	7	5
59	R:R:M99	R:R:S138	21.958	3.07	No	No	0	5	8
60	R:R:L102	R:R:V192	18.5973	7.45	No	No	0	7	6
61	R:R:Y197	R:R:Y282	33.1844	4.96	Yes	Yes	2	9	9
62	R:R:I196	R:R:Y109	14.444	4.84	No	Yes	0	6	8
63	R:R:I196	R:R:V192	16.5356	3.07	No	No	0	6	6
64	R:R:L110	R:R:V106	16.2198	2.98	No	No	0	5	6
65	R:R:L102	R:R:V106	16.5654	2.98	No	No	0	7	6
66	R:R:L110	R:R:L114	15.9933	4.15	No	No	0	5	5
67	R:R:L114	R:R:Y118	20.9331	3.52	No	Yes	0	5	8
68	R:R:L114	R:R:V121	11.0237	2.98	No	No	0	5	4
69	R:R:P145	R:R:T144	11.5243	3.5	Yes	No	0	5	5
70	R:R:M174	R:R:Y254	17.9657	2.39	No	Yes	0	3	4
71	R:R:M174	R:R:M177	34.537	4.33	No	Yes	0	3	5
72	R:R:M174	R:R:R169	15.9695	6.2	No	No	0	3	4
73	R:R:L253	R:R:R169	14.4202	6.07	No	No	0	4	4
74	R:R:L232	R:R:Y197	27.8751	12.89	No	Yes	0	8	9
75	R:R:E225	R:R:I204	17.2804	1.37	No	No	0	7	8
76	R:R:I204	R:R:T228	22.6016	6.08	No	No	0	8	7
77	R:R:L232	R:R:T228	25.4261	2.95	No	No	0	8	7
78	R:R:L253	R:R:V259	12.8829	2.98	No	Yes	0	4	4
79	L:L:?1	R:R:H272	35.0077	6.79	Yes	Yes	1	0	7
80	R:R:D58	R:R:L54	25.1102	8.14	Yes	Yes	2	9	9
81	R:R:L101	R:R:L54	12.0963	4.15	No	Yes	2	8	9
82	R:R:I104	R:R:Y282	11.7269	7.25	No	Yes	2	8	9
83	R:R:H95	R:R:L91	20.7186	3.86	Yes	Yes	1	6	4
84	R:R:L91	R:R:M172	11.0893	4.24	Yes	Yes	1	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E19	R:R:Y15	3.37	1	Yes	Yes	5	4	2	2
R:R:I268	R:R:Y15	12.09	1	No	Yes	5	4	1	2
R:R:E19	R:R:H272	18.46	1	Yes	Yes	5	7	2	1
R:R:H272	R:R:V65	4.15	1	Yes	No	7	7	1	2
R:R:F168	R:R:T87	6.49	1	Yes	No	5	4	1	2
R:R:M172	R:R:T87	12.04	1	Yes	No	4	4	2	2
R:R:H95	R:R:L91	3.86	1	Yes	Yes	6	4	2	2
R:R:L91	R:R:M172	4.24	1	Yes	Yes	4	4	2	2
R:R:L91	R:R:Y176	5.86	1	Yes	Yes	4	6	2	2
R:R:L91	R:R:M177	5.65	1	Yes	Yes	4	5	2	1
R:R:H95	R:R:T94	4.11	1	Yes	No	6	6	2	1
R:R:T94	R:R:W243	4.85	0	No	Yes	6	8	1	2
L:L:?1	R:R:T94	4.87	1	Yes	No	0	6	0	1
R:R:F168	R:R:M172	13.68	1	Yes	Yes	5	4	1	2
R:R:F168	R:R:M177	7.46	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:F168	32.16	1	Yes	Yes	0	5	0	1
R:R:M174	R:R:M177	4.33	0	No	Yes	3	5	2	1
R:R:M177	R:R:Y176	5.99	1	Yes	Yes	5	6	1	2
L:L:?1	R:R:M177	4.67	1	Yes	Yes	0	5	0	1
R:R:G267	R:R:L246	3.42	0	No	No	6	6	2	1
L:L:?1	R:R:L246	4.57	1	Yes	No	0	6	0	1
L:L:?1	R:R:N250	9.97	1	Yes	No	0	5	0	1
R:R:L264	R:R:Q261	6.65	0	No	No	4	2	1	2
L:L:?1	R:R:L264	4.57	1	Yes	No	0	4	0	1
R:R:H272	R:R:I268	6.63	1	Yes	No	7	5	1	1
L:L:?1	R:R:I268	6.6	1	Yes	No	0	5	0	1
L:L:?1	R:R:H272	6.79	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YH2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	252
Number of Links	285
Number of Hubs	39
Number of Links mediated by Hubs	152
Number of Communities	10
Number of Nodes involved in Communities	54
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	41825
Length Of Smallest Path	3
Average Path Length	13.1131
Length of Longest Path	29
Minimum Path Strength	1.31
Average Path Strength	6.30232
Maximum Path Strength	25.4
Minimum Path Correlation	0.7
Average Path Correlation	0.922428
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.6238
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6355
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • synapse • cell junction • intracellular anatomical structure • cytoplasm • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • G-protein beta-subunit binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled adenosine receptor activity • identical protein binding • host cell surface binding • host cell surface receptor binding • bioluminescence • generation of precursor metabolites and energy • viral process • fusion of virus membrane with host endosome membrane • membrane fusion involved in viral entry into host cell • membrane organization • membrane fusion • fusion of virus membrane with host plasma membrane • virion attachment to host cell • biological process involved in interspecies interaction between organisms • adhesion of symbiont to host cell • viral life cycle • adhesion of symbiont to host • biological process involved in interaction with host • biological process involved in symbiotic interaction • non-lytic viral release • viral budding • virion assembly • exit from host cell • viral budding from plasma membrane • viral release from host cell • import into cell • receptor-mediated endocytosis of virus by host cell • transport • establishment of localization • vesicle-mediated transport • symbiont entry into host cell • clathrin-dependent endocytosis • symbiont entry into host • clathrin-dependent endocytosis of virus by host cell • receptor-mediated endocytosis • endocytosis • endocytosis involved in viral entry into host cell • somatodendritic compartment • dendrite • dendritic tree • virion component • virion membrane • viral membrane • viral envelope • host cell plasma membrane • host cellular component • host cell part • host cell membrane
SCOP2	Domain Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ADN
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ADN
Name	Adenosine
Synonyms	Adenosine
Identifier
Formula	C10 H13 N5 O4
Molecular Weight	267.241
SMILES
PubChem	60961
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	4
Total Bonds	34
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P0DMS8
Sequence	>8YH2_nogp_Chain_R S V T Y I T E I I G L C A I V G N V L V I V V K L N P S L Q T T T F Y F I V S L A L A D I A V G V L V M P L A I V S L G T I H F Y S C L F M T C L L I F T H A S I M S L L A I A V D R Y L R V K L T V R Y R V T T R R I W L A L G L C W L V S F L V G L T P M F G W N M K L S N T F L C F S V M R M D Y M V Y F S F W I P L V V M C A I Y D I F Y I I R N L E F K T A K S L L V L F L F A L W L P L S I I N C I Y F G V P Q V L Y G I L L S H A N S M M N P I V Y A Y K I K K F K E T Y L L I W T S V L W I V M R Q S A D E L P R R F L L V F R L C L D Q T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YH6	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-	Gi1/β1/γ2	3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-		3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH0	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-	Gi1/β1/γ2	2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH0 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-		2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8X17	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.19	2024-04-24	10.1038/s41467-024-47207-6
	8X17 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.19	2024-04-24	10.1038/s41467-024-47207-6
	8X16	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	Gi1/β1/γ2	3.29	2024-04-24	10.1038/s41467-024-47207-6
	8X16 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.29	2024-04-24	10.1038/s41467-024-47207-6

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