psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L91	5.45	Yes	Yes	1	0	4
2	L:L:?1	R:R:T94	13.55	Yes	No	0	0	6
3	L:L:?1	R:R:H95	3.38	Yes	Yes	1	0	6
4	L:L:?1	R:R:Q167	3.5	Yes	No	0	0	5
5	L:L:?1	R:R:F168	47.99	Yes	Yes	1	0	5
6	L:L:?1	R:R:V169	4.89	Yes	No	0	0	4
7	L:L:?1	R:R:M177	8.36	Yes	Yes	1	0	5
8	L:L:?1	R:R:L246	7.27	Yes	No	1	0	6
9	L:L:?1	R:R:N250	5.41	Yes	No	1	0	5
10	L:L:?1	R:R:L264	11.82	Yes	No	0	0	4
11	L:L:?1	R:R:I268	15.94	Yes	Yes	1	0	5
12	L:L:?1	R:R:S271	2.96	Yes	Yes	1	0	7
13	L:L:?1	R:R:H272	9.29	Yes	Yes	1	0	7
14	R:R:L10	R:R:T14	2.95	No	No	0	4	4
15	R:R:A11	R:R:L262	4.73	No	No	0	4	2
16	R:R:N12	R:R:Q261	5.28	No	No	1	3	2
17	R:R:N12	R:R:Y265	6.98	No	Yes	1	3	4
18	R:R:E19	R:R:Y15	17.96	Yes	Yes	1	5	4
19	R:R:S73	R:R:Y15	5.09	No	Yes	1	5	4
20	R:R:Y15	R:R:Y265	31.77	Yes	Yes	1	4	4
21	R:R:I268	R:R:Y15	6.04	Yes	Yes	1	5	4
22	R:R:L269	R:R:Y15	5.86	Yes	Yes	1	5	4
23	R:R:I16	R:R:I70	10.3	No	No	0	5	6
24	R:R:I16	R:R:S73	3.1	No	No	0	5	5
25	R:R:L269	R:R:M18	8.48	Yes	No	0	5	4
26	R:R:E19	R:R:M66	4.06	Yes	No	0	5	6
27	R:R:E19	R:R:L269	3.98	Yes	Yes	1	5	5
28	R:R:E19	R:R:H272	12.31	Yes	Yes	1	5	7
29	R:R:C25	R:R:F21	6.98	No	No	0	5	4
30	R:R:I22	R:R:M276	7.29	No	Yes	0	7	6
31	R:R:C25	R:R:M276	4.86	No	Yes	0	5	6
32	R:R:A26	R:R:S275	3.42	No	No	0	7	9
33	R:R:I27	R:R:V63	3.07	No	No	0	6	4
34	R:R:A55	R:R:N30	3.13	No	Yes	0	9	9
35	R:R:D58	R:R:N30	12.12	Yes	Yes	0	9	9
36	R:R:I59	R:R:N30	4.25	No	Yes	0	7	9
37	R:R:N30	R:R:P279	6.52	Yes	No	0	9	9
38	R:R:L32	R:R:V36	2.98	No	Yes	0	6	8
39	R:R:L32	R:R:Y293	9.38	No	No	0	6	7
40	R:R:A283	R:R:V33	3.39	No	No	3	7	9
41	R:R:F289	R:R:V33	5.24	Yes	No	3	8	9
42	R:R:I34	R:R:V52	4.61	No	No	0	7	5
43	R:R:F289	R:R:V36	6.55	Yes	Yes	0	8	8
44	R:R:T292	R:R:V36	4.76	No	Yes	0	7	8
45	R:R:L43	R:R:V37	2.98	Yes	No	3	8	8
46	R:R:F48	R:R:V37	3.93	Yes	No	3	9	8
47	R:R:V37	R:R:V52	4.81	No	No	0	8	5
48	R:R:K38	R:R:Q44	4.07	No	No	0	1	7
49	R:R:N40	R:R:P41	3.26	No	No	0	5	6
50	R:R:N40	R:R:S42	8.94	No	No	0	5	5
51	R:R:N40	R:R:T292	5.85	No	No	0	5	7
52	R:R:L43	R:R:S42	3	Yes	No	3	8	5
53	R:R:K288	R:R:S42	6.12	No	No	3	6	5
54	R:R:F48	R:R:L43	18.27	Yes	Yes	3	9	8
55	R:R:K288	R:R:L43	5.64	No	Yes	3	6	8
56	R:R:L43	R:R:T292	2.95	Yes	No	0	8	7
57	R:R:F48	R:R:T45	6.49	Yes	No	0	9	7
58	R:R:F50	R:R:T46	3.89	Yes	No	2	8	5
59	R:R:T46	R:R:Y118	7.49	No	Yes	2	5	8
60	R:R:I127	R:R:T46	7.6	Yes	No	2	6	5
61	R:R:R111	R:R:T47	5.17	No	No	0	8	8
62	R:R:F48	R:R:I286	5.02	Yes	No	0	9	8
63	R:R:F289	R:R:F48	5.36	Yes	Yes	3	8	9
64	R:R:I127	R:R:Y49	6.04	Yes	No	0	6	4
65	R:R:W128	R:R:Y49	7.72	No	No	0	1	4
66	R:R:F50	R:R:I104	3.77	Yes	Yes	2	8	8
67	R:R:D107	R:R:F50	14.33	No	Yes	2	9	8
68	R:R:F50	R:R:I127	5.02	Yes	Yes	2	8	6
69	R:R:I104	R:R:I51	2.94	Yes	No	0	8	8
70	R:R:I286	R:R:I51	2.94	No	No	0	8	8
71	R:R:S100	R:R:S53	4.89	No	No	0	7	9
72	R:R:L131	R:R:S53	4.5	No	No	0	7	9
73	R:R:S53	R:R:W135	6.18	No	No	0	9	9
74	R:R:D58	R:R:L54	4.07	Yes	Yes	2	9	9
75	R:R:L54	R:R:S100	7.51	Yes	No	0	9	7
76	R:R:L101	R:R:L54	6.92	No	Yes	2	8	9
77	R:R:I104	R:R:L54	4.28	Yes	Yes	2	8	9
78	R:R:L54	R:R:N278	12.36	Yes	Yes	2	9	9
79	R:R:D58	R:R:S97	2.94	Yes	No	0	9	9
80	R:R:D58	R:R:S275	4.42	Yes	No	0	9	9
81	R:R:D58	R:R:N278	10.77	Yes	Yes	2	9	9
82	R:R:A60	R:R:F93	4.16	No	Yes	0	6	6
83	R:R:G62	R:R:V61	3.68	No	No	0	6	8
84	R:R:V61	R:R:V65	6.41	No	Yes	0	8	7
85	R:R:S275	R:R:V61	4.85	No	No	0	9	8
86	R:R:L64	R:R:V63	4.47	No	No	0	4	4
87	R:R:F93	R:R:L64	12.18	Yes	No	0	6	4
88	R:R:L90	R:R:V65	4.47	No	Yes	0	6	7
89	R:R:F93	R:R:V65	5.24	Yes	Yes	0	6	7
90	R:R:H272	R:R:V65	4.15	Yes	Yes	0	7	7
91	R:R:M66	R:R:P67	11.74	No	No	0	6	8
92	R:R:L68	R:R:M86	4.24	No	No	0	5	6
93	R:R:L68	R:R:L90	4.15	No	No	0	5	6
94	R:R:M86	R:R:V71	3.04	No	No	0	6	4
95	R:R:C166	R:R:V72	5.12	No	No	0	9	5
96	R:R:S73	R:R:Y265	5.09	No	Yes	1	5	4
97	R:R:I76	R:R:I78	7.36	No	No	0	2	5
98	R:R:H79	R:R:I78	3.98	No	No	0	7	5
99	R:R:I78	R:R:S82	4.64	No	No	0	5	5
100	R:R:F163	R:R:H79	6.79	No	No	0	2	7
101	R:R:F80	R:R:Y81	3.09	Yes	No	0	3	1
102	R:R:F80	R:R:N150	6.04	Yes	Yes	4	3	5
103	R:R:F80	R:R:K152	17.37	Yes	No	4	3	4
104	R:R:F80	R:R:V171	6.55	Yes	Yes	0	3	5
105	R:R:C166	R:R:C83	7.28	No	No	0	9	9
106	R:R:L84	R:R:T87	4.42	No	Yes	0	6	4
107	R:R:L84	R:R:P145	4.93	No	Yes	0	6	5
108	R:R:L84	R:R:N150	6.87	No	Yes	0	6	5
109	R:R:F85	R:R:L89	12.18	No	No	0	5	5
110	R:R:F85	R:R:M146	6.22	No	No	0	5	5
111	R:R:F168	R:R:T87	3.89	Yes	Yes	1	5	4
112	R:R:T87	R:R:V171	4.76	Yes	Yes	0	4	5
113	R:R:M172	R:R:T87	9.03	Yes	Yes	1	4	4
114	R:R:C88	R:R:P145	5.65	No	Yes	0	6	5
115	R:R:C88	R:R:M146	6.48	No	No	0	6	5
116	R:R:F93	R:R:L89	7.31	Yes	No	0	6	5
117	R:R:L91	R:R:M172	5.65	Yes	Yes	1	4	4
118	R:R:L91	R:R:Y176	3.52	Yes	Yes	1	4	6
119	R:R:L91	R:R:M177	8.48	Yes	Yes	1	4	5
120	R:R:F139	R:R:I92	10.05	No	Yes	0	4	5
121	R:R:G142	R:R:I92	3.53	No	Yes	0	7	5
122	R:R:I92	R:R:L143	5.71	Yes	No	0	5	4
123	R:R:T94	R:R:W243	4.85	No	Yes	0	6	8
124	R:R:H95	R:R:V141	8.3	Yes	No	1	6	4
125	R:R:H95	R:R:S181	8.37	Yes	No	0	6	5
126	R:R:H95	R:R:W185	5.29	Yes	Yes	1	6	5
127	R:R:A96	R:R:W135	3.89	No	No	0	7	9
128	R:R:A96	R:R:S138	3.42	No	No	0	7	8
129	R:R:I186	R:R:I98	2.94	No	No	2	7	8
130	R:R:F239	R:R:I98	5.02	No	No	2	8	8
131	R:R:I98	R:R:W243	12.92	No	Yes	2	8	8
132	R:R:C134	R:R:M99	3.24	No	No	0	7	5
133	R:R:M99	R:R:V137	3.04	No	No	1	5	4
134	R:R:M99	R:R:W185	3.49	No	Yes	1	5	5
135	R:R:L101	R:R:N278	6.87	No	Yes	2	8	9
136	R:R:L101	R:R:Y282	5.86	No	Yes	2	8	9
137	R:R:L102	R:R:P189	3.28	No	No	0	7	8
138	R:R:I104	R:R:R108	3.76	Yes	Yes	2	8	9
139	R:R:I104	R:R:Y282	7.25	Yes	Yes	2	8	9
140	R:R:A105	R:R:M193	6.44	No	No	0	8	8
141	R:R:D107	R:R:R111	8.34	No	No	2	9	8
142	R:R:D107	R:R:Y118	9.2	No	Yes	2	9	8
143	R:R:R108	R:R:Y197	6.17	Yes	Yes	2	9	9
144	R:R:R108	R:R:V235	3.92	Yes	No	2	9	8
145	R:R:R108	R:R:Y282	9.26	Yes	Yes	2	9	9
146	R:R:K113	R:R:Y109	7.17	No	Yes	0	6	8
147	R:R:I196	R:R:Y109	16.92	No	Yes	6	6	8
148	R:R:D199	R:R:Y109	12.64	No	Yes	0	4	8
149	R:R:I200	R:R:Y109	3.63	Yes	Yes	6	9	8
150	R:R:L110	R:R:L114	5.54	No	No	0	5	5
151	R:R:R111	R:R:Y118	14.4	No	Yes	2	8	8
152	R:R:I200	R:R:V112	4.61	Yes	No	0	9	9
153	R:R:I203	R:R:V112	4.61	No	No	0	5	9
154	R:R:T115	R:R:V116	7.93	No	No	0	8	6
155	R:R:T122	R:R:Y118	22.47	No	Yes	0	6	8
156	R:R:R126	R:R:V121	3.92	No	Yes	0	5	4
157	R:R:I127	R:R:T122	3.04	Yes	No	0	6	6
158	R:R:R126	R:R:T123	5.17	No	No	0	5	8
159	R:R:H124	R:R:W128	4.23	No	No	0	3	1
160	R:R:R125	R:R:W128	4	No	No	0	4	1
161	R:R:V137	R:R:W185	4.9	No	Yes	1	4	5
162	R:R:V141	R:R:W185	9.81	No	Yes	1	4	5
163	R:R:P145	R:R:T144	5.25	Yes	No	1	5	5
164	R:R:T144	R:R:W149	3.64	No	Yes	1	5	6
165	R:R:T144	R:R:Y176	9.99	No	Yes	1	5	6
166	R:R:M172	R:R:P145	6.71	Yes	Yes	1	4	5
167	R:R:P145	R:R:Y176	6.95	Yes	Yes	1	5	6
168	R:R:W149	R:R:Y176	17.36	Yes	Yes	1	6	6
169	R:R:F180	R:R:W149	15.03	No	Yes	1	5	6
170	R:R:K152	R:R:N150	6.99	No	Yes	4	4	5
171	R:R:M151	R:R:T154	7.53	No	Yes	4	4	2
172	R:R:H158	R:R:M151	9.19	No	No	4	2	4
173	R:R:H158	R:R:T154	9.58	No	Yes	4	2	2
174	R:R:R173	R:R:T154	5.17	No	Yes	0	4	2
175	R:R:E156	R:R:R159	11.63	No	No	0	2	2
176	R:R:H158	R:R:Y157	7.62	No	No	0	2	4
177	R:R:L164	R:R:V161	5.96	No	No	0	4	3
178	R:R:F163	R:R:T162	6.49	No	No	0	2	3
179	R:R:F168	R:R:M172	8.71	Yes	Yes	1	5	4
180	R:R:F168	R:R:M177	7.46	Yes	Yes	1	5	5
181	R:R:S170	R:R:V171	3.23	No	Yes	0	4	5
182	R:R:D175	R:R:R173	3.57	No	No	0	4	4
183	R:R:M174	R:R:N250	7.01	No	No	0	3	5
184	R:R:D175	R:R:Y179	5.75	No	No	5	4	3
185	R:R:D175	R:R:Y254	12.64	No	Yes	5	4	4
186	R:R:F180	R:R:Y176	7.22	No	Yes	1	5	6
187	R:R:M177	R:R:N250	4.21	Yes	No	1	5	5
188	R:R:V178	R:R:Y179	3.79	No	No	5	5	3
189	R:R:C251	R:R:V178	3.42	No	No	0	5	5
190	R:R:V178	R:R:Y254	6.31	No	Yes	5	5	4
191	R:R:Y179	R:R:Y254	6.95	No	Yes	5	3	4
192	R:R:F180	R:R:W185	4.01	No	Yes	1	5	5
193	R:R:F182	R:R:L183	3.65	Yes	No	0	5	4
194	R:R:F182	R:R:I186	3.77	Yes	No	0	5	7
195	R:R:F182	R:R:F187	7.5	Yes	No	0	5	4
196	R:R:F182	R:R:S247	14.53	Yes	No	0	5	6
197	R:R:T184	R:R:W185	13.34	No	Yes	0	3	5
198	R:R:I186	R:R:W243	3.52	No	Yes	2	7	8
199	R:R:F187	R:R:V191	7.87	No	No	0	4	4
200	R:R:I188	R:R:P189	3.39	No	No	0	4	8
201	R:R:F239	R:R:L190	3.65	No	No	0	8	6
202	R:R:M193	R:R:Y197	8.38	No	Yes	2	8	9
203	R:R:L236	R:R:M193	4.24	No	No	2	7	8
204	R:R:C194	R:R:L236	4.76	No	No	0	4	7
205	R:R:I196	R:R:I200	2.94	No	Yes	6	6	9
206	R:R:V235	R:R:Y197	6.31	No	Yes	2	8	9
207	R:R:L236	R:R:Y197	4.69	No	Yes	2	7	9
208	R:R:Y197	R:R:Y282	3.97	Yes	Yes	2	9	9
209	R:R:L198	R:R:Y202	16.41	No	No	0	4	3
210	R:R:D199	R:R:I203	5.6	No	No	0	4	5
211	R:R:E225	R:R:F201	5.83	No	No	0	7	5
212	R:R:F201	R:R:T228	5.19	No	No	0	5	7
213	R:R:A229	R:R:F201	4.16	No	No	0	7	5
214	R:R:R205	R:R:Y202	5.14	No	No	0	5	3
215	R:R:I204	R:R:T228	3.04	No	No	0	8	7
216	R:R:N206	R:R:R205	7.23	No	No	0	4	5
217	R:R:E225	R:R:R205	8.14	No	No	0	7	5
218	R:R:L208	R:R:R224	7.29	No	No	0	4	5
219	R:R:F233	R:R:F237	7.5	No	No	0	5	4
220	R:R:V235	R:R:Y282	6.31	No	Yes	2	8	9
221	R:R:L238	R:R:M277	8.48	No	No	0	6	6
222	R:R:F239	R:R:W243	15.03	No	Yes	2	8	8
223	R:R:A240	R:R:L244	6.3	No	No	0	6	6
224	R:R:S242	R:R:W243	3.71	No	Yes	2	8	8
225	R:R:N274	R:R:S242	8.94	No	No	2	9	8
226	R:R:N274	R:R:W243	5.65	No	Yes	2	9	8
227	R:R:L270	R:R:P245	3.28	No	No	0	7	9
228	R:R:I268	R:R:L246	5.71	Yes	No	1	5	6
229	R:R:L246	R:R:S271	3	No	Yes	1	6	7
230	R:R:I249	R:R:V259	3.07	No	Yes	0	5	4
231	R:R:I253	R:R:V259	6.14	No	Yes	0	4	4
232	R:R:F255	R:R:Y254	9.28	No	Yes	0	4	4
233	R:R:P260	R:R:V259	3.53	No	Yes	8	4	4
234	R:R:V259	R:R:V263	3.21	Yes	No	8	4	4
235	R:R:P260	R:R:V263	10.6	No	No	8	4	4
236	R:R:Q261	R:R:Y265	14.65	No	Yes	1	2	4
237	R:R:I268	R:R:S271	3.1	Yes	Yes	1	5	7
238	R:R:H272	R:R:I268	5.3	Yes	Yes	1	7	5
239	R:R:H272	R:R:S271	4.18	Yes	Yes	1	7	7
240	R:R:A273	R:R:M276	3.22	No	Yes	0	6	6
241	R:R:N274	R:R:N278	9.54	No	Yes	2	9	9
242	R:R:V281	R:R:Y282	3.79	No	Yes	0	8	9
243	R:R:A283	R:R:F289	8.32	No	Yes	3	7	8
244	R:R:K290	R:R:Y284	14.33	No	No	0	8	5
245	R:R:Y284	R:R:Y293	3.97	No	No	0	5	7
246	R:R:L297	R:R:Y293	11.72	No	No	0	6	7
247	R:R:L294	R:R:L297	4.15	No	No	0	4	6
248	R:R:C300	R:R:I296	4.91	No	No	0	3	5
249	R:R:I20	R:R:M66	2.92	No	No	0	4	6
250	R:R:I253	R:R:M174	2.92	No	No	0	4	3
251	R:R:I204	R:R:K207	2.91	No	No	0	8	7
252	R:R:Q167	R:R:S165	2.89	No	No	0	5	5
253	R:R:M276	R:R:M277	2.89	Yes	No	0	6	6
254	R:R:I22	R:R:L269	2.85	No	Yes	0	7	5
255	R:R:I92	R:R:L89	2.85	Yes	No	0	5	5
256	R:R:K298	R:R:L297	2.82	No	No	0	5	6
257	R:R:A103	R:R:F50	2.77	No	Yes	0	6	8
258	R:R:L241	R:R:L270	2.77	No	No	0	5	7
259	R:R:E291	R:R:K290	2.7	No	No	0	5	8
260	R:R:A57	R:R:W135	2.59	No	No	0	8	9
261	R:R:F80	R:R:M151	2.49	Yes	No	4	3	4
262	R:R:K152	R:R:R159	2.48	No	No	0	4	2
263	R:R:L232	R:R:Y197	2.34	No	Yes	0	8	9
264	R:R:Q44	R:R:Y49	2.25	No	No	0	7	4
265	R:R:G23	R:R:G62	2.11	No	No	0	6	6
266	R:R:C166	R:R:G75	1.96	No	No	0	9	5
267	R:R:G29	R:R:V28	1.84	No	No	0	8	4
268	R:R:A195	R:R:C194	1.81	No	No	0	4	4
269	R:R:G267	R:R:I249	1.76	No	No	0	6	5
270	R:R:G257	R:R:I252	1.76	No	No	0	1	4
271	R:R:G267	R:R:M266	1.75	No	No	0	6	4
272	R:R:C83	R:R:S82	1.72	No	No	0	9	5
273	R:R:G29	R:R:L32	1.71	No	No	0	8	6
274	R:R:C35	R:R:V31	1.71	No	No	0	4	4
275	R:R:G75	R:R:L74	1.71	No	No	0	5	4
276	R:R:C83	R:R:V171	1.71	No	Yes	0	9	5
277	R:R:G132	R:R:L131	1.71	No	No	0	4	7
278	R:R:G267	R:R:L270	1.71	No	No	0	6	7
279	R:R:G148	R:R:N150	1.7	No	Yes	0	6	5
280	R:R:A11	R:R:T14	1.68	No	No	0	4	4
281	R:R:C35	R:R:I34	1.64	No	No	0	4	7
282	R:R:L244	R:R:P245	1.64	No	No	0	6	9
283	R:R:S9	R:R:V13	1.62	No	No	0	4	3
284	R:R:S155	R:R:T154	1.6	No	Yes	0	3	2
285	R:R:V191	R:R:V192	1.6	No	No	7	4	6
286	R:R:T122	R:R:V121	1.59	No	Yes	0	6	4
287	R:R:A69	R:R:L90	1.58	No	No	0	6	6
288	R:R:T14	R:R:T17	1.57	No	No	0	4	6
289	R:R:I296	R:R:V36	1.54	No	Yes	0	5	8
290	R:R:I188	R:R:V191	1.54	No	No	7	4	4
291	R:R:I188	R:R:V192	1.54	No	No	7	4	6
292	R:R:I252	R:R:V259	1.54	No	Yes	0	4	4
293	R:R:L232	R:R:S231	1.5	No	No	0	8	8
294	R:R:L56	R:R:V52	1.49	No	No	0	6	5
295	R:R:L110	R:R:V106	1.49	No	No	0	5	6
296	R:R:L114	R:R:V121	1.49	No	Yes	0	5	4
297	R:R:L133	R:R:V137	1.49	No	No	0	3	4
298	R:R:I200	R:R:I204	1.47	Yes	No	0	9	8
299	R:R:I20	R:R:L24	1.43	No	No	0	4	4
300	R:R:I27	R:R:L24	1.43	No	No	0	6	4
301	R:R:I200	R:R:L232	1.43	Yes	No	0	9	8
302	R:R:K285	R:R:L234	1.41	No	No	0	7	6
303	R:R:L234	R:R:L238	1.38	No	No	0	6	6
304	R:R:E291	R:R:K287	1.35	No	No	0	5	5
305	R:R:R117	R:R:V121	1.31	No	Yes	0	5	4
306	R:R:V161	R:R:Y157	1.26	No	No	0	3	4
307	R:R:F237	R:R:L234	1.22	No	No	0	4	6
308	R:R:F237	R:R:L241	1.22	No	No	0	4	5
309	R:R:L129	R:R:R125	1.21	No	No	0	1	4
310	R:R:L153	R:R:W149	1.14	No	Yes	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.7546	13	1	0
2	R:R:Y15	13.344	5	1	4
3	R:R:E19	9.5775	4	1	5
4	R:R:N30	6.505	4	0	9
5	R:R:V36	3.9575	4	0	8
6	R:R:L43	6.568	5	3	8
7	R:R:F48	7.814	5	3	9
8	R:R:F50	5.956	5	2	8
9	R:R:L54	7.028	5	2	9
10	R:R:D58	6.864	5	2	9
11	R:R:V65	5.0675	4	0	7
12	R:R:F80	7.108	5	4	3
13	R:R:T87	5.525	4	1	4
14	R:R:L91	5.775	4	1	4
15	R:R:I92	5.535	4	0	5
16	R:R:F93	7.2225	4	0	6
17	R:R:H95	6.335	4	1	6
18	R:R:I104	4.4	5	2	8
19	R:R:R108	5.7775	4	2	9
20	R:R:Y109	10.09	4	6	8
21	R:R:Y118	13.39	4	2	8
22	R:R:V121	2.0775	4	0	4
23	R:R:I127	5.425	4	2	6
24	R:R:P145	5.898	5	1	5
25	R:R:W149	9.2925	4	1	6
26	R:R:N150	5.4	4	4	5
27	R:R:T154	5.97	4	4	2
28	R:R:F168	17.0125	4	1	5
29	R:R:V171	4.0625	4	0	5
30	R:R:M172	7.525	4	1	4
31	R:R:Y176	9.008	5	1	6
32	R:R:M177	7.1275	4	1	5
33	R:R:F182	7.3625	4	0	5
34	R:R:W185	6.80667	6	1	5
35	R:R:Y197	5.31	6	2	9
36	R:R:I200	2.816	5	6	9
37	R:R:W243	7.61333	6	2	8
38	R:R:Y254	8.795	4	5	4
39	R:R:V259	3.498	5	8	4
40	R:R:Y265	14.6225	4	1	4
41	R:R:I268	7.218	5	1	5
42	R:R:L269	5.2925	4	1	5
43	R:R:S271	3.31	4	1	7
44	R:R:H272	7.046	5	1	7
45	R:R:M276	4.565	4	0	6
46	R:R:N278	9.885	4	2	9
47	R:R:Y282	6.07333	6	2	9
48	R:R:F289	6.3675	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I268	21.904	15.94	Yes	Yes	1	0	5
2	R:R:I268	R:R:Y15	25.5649	6.04	Yes	Yes	1	5	4
3	L:L:?1	R:R:H272	34.0751	9.29	Yes	Yes	1	0	7
4	R:R:E19	R:R:H272	47.4277	12.31	Yes	Yes	1	5	7
5	R:R:L269	R:R:Y15	12.075	5.86	Yes	Yes	1	5	4
6	R:R:E19	R:R:L269	30.9362	3.98	Yes	Yes	1	5	5
7	R:R:E19	R:R:M66	11.3401	4.06	Yes	No	0	5	6
8	R:R:I22	R:R:L269	36.5478	2.85	No	Yes	0	7	5
9	R:R:I22	R:R:M276	33.3196	7.29	No	Yes	0	7	6
10	R:R:H272	R:R:V65	55.5189	4.15	Yes	Yes	0	7	7
11	R:R:V61	R:R:V65	66.962	6.41	No	Yes	0	8	7
12	R:R:S275	R:R:V61	67.9511	4.85	No	No	0	9	8
13	R:R:F93	R:R:V65	27.2615	5.24	Yes	Yes	0	6	7
14	L:L:?1	R:R:T94	94.0174	13.55	Yes	No	0	0	6
15	R:R:T94	R:R:W243	93.9213	4.85	No	Yes	0	6	8
16	R:R:N274	R:R:W243	88.6325	5.65	No	Yes	2	9	8
17	R:R:N274	R:R:N278	89.1339	9.54	No	Yes	2	9	9
18	R:R:D58	R:R:N278	15.0148	10.77	Yes	Yes	2	9	9
19	R:R:D58	R:R:N30	11.9995	12.12	Yes	Yes	0	9	9
20	R:R:D58	R:R:S275	68.7479	4.42	Yes	No	0	9	9
21	R:R:L54	R:R:N278	54.104	12.36	Yes	Yes	2	9	9
22	R:R:I104	R:R:L54	100	4.28	Yes	Yes	2	8	9
23	R:R:I104	R:R:I51	63.6926	2.94	Yes	No	0	8	8
24	R:R:I286	R:R:I51	62.0441	2.94	No	No	0	8	8
25	R:R:F48	R:R:I286	60.6086	5.02	Yes	No	0	9	8
26	R:R:F289	R:R:F48	31.9184	5.36	Yes	Yes	3	8	9
27	R:R:F289	R:R:V36	26.6571	6.55	Yes	Yes	0	8	8
28	R:R:L32	R:R:V36	22.4535	2.98	No	Yes	0	6	8
29	R:R:L32	R:R:Y293	16.7044	9.38	No	No	0	6	7
30	R:R:F48	R:R:V37	11.7934	3.93	Yes	No	3	9	8
31	R:R:V37	R:R:V52	10.8524	4.81	No	No	0	8	5
32	R:R:F48	R:R:L43	14.9873	18.27	Yes	Yes	3	9	8
33	R:R:F50	R:R:I104	45.8617	3.77	Yes	Yes	2	8	8
34	R:R:F50	R:R:I127	31.2521	5.02	Yes	Yes	2	8	6
35	R:R:I127	R:R:Y49	14.6301	6.04	Yes	No	0	6	4
36	R:R:L54	R:R:S100	17.9614	7.51	Yes	No	0	9	7
37	R:R:S100	R:R:S53	15.7634	4.89	No	No	0	7	9
38	R:R:L101	R:R:N278	39.5219	6.87	No	Yes	2	8	9
39	R:R:L90	R:R:V65	12.0475	4.47	No	Yes	0	6	7
40	L:L:?1	R:R:F168	66.6598	47.99	Yes	Yes	1	0	5
41	R:R:F168	R:R:T87	66.7079	3.89	Yes	Yes	1	5	4
42	R:R:T87	R:R:V171	59.9217	4.76	Yes	Yes	0	4	5
43	R:R:C83	R:R:V171	23.2365	1.71	No	Yes	0	9	5
44	R:R:C83	R:R:S82	13.016	1.72	No	No	0	9	5
45	R:R:I78	R:R:S82	10.8799	4.64	No	No	0	5	5
46	R:R:F80	R:R:V171	36.8775	6.55	Yes	Yes	0	3	5
47	R:R:L84	R:R:T87	10.9211	4.42	No	Yes	0	6	4
48	R:R:L84	R:R:N150	11.8621	6.87	No	Yes	0	6	5
49	R:R:F93	R:R:L89	15.1865	7.31	Yes	No	0	6	5
50	L:L:?1	R:R:L91	15.4612	5.45	Yes	Yes	1	0	4
51	R:R:L91	R:R:Y176	11.4568	3.52	Yes	Yes	1	4	6
52	R:R:I92	R:R:L89	10.296	2.85	Yes	No	0	5	5
53	L:L:?1	R:R:H95	17.2333	3.38	Yes	Yes	1	0	6
54	R:R:H95	R:R:W185	12.13	5.29	Yes	Yes	1	6	5
55	R:R:I186	R:R:W243	18.8131	3.52	No	Yes	2	7	8
56	R:R:L101	R:R:Y282	49.8523	5.86	No	Yes	2	8	9
57	R:R:F182	R:R:I186	17.1784	3.77	Yes	No	0	5	7
58	R:R:F182	R:R:F187	11.5736	7.5	Yes	No	0	5	4
59	R:R:Y197	R:R:Y282	63.672	3.97	Yes	Yes	2	9	9
60	R:R:L232	R:R:Y197	64.5992	2.34	No	Yes	0	8	9
61	R:R:I200	R:R:L232	58.2183	1.43	Yes	No	0	9	8
62	R:R:I200	R:R:Y109	10.3853	3.63	Yes	Yes	6	9	8
63	R:R:I127	R:R:T122	16.361	3.04	Yes	No	0	6	6
64	R:R:T122	R:R:V121	14.4653	1.59	No	Yes	0	6	4
65	R:R:F80	R:R:M151	31.5132	2.49	Yes	No	4	3	4
66	R:R:M151	R:R:T154	21.7529	7.53	No	Yes	4	4	2
67	R:R:R173	R:R:T154	18.1675	5.17	No	Yes	0	4	2
68	R:R:D175	R:R:R173	16.203	3.57	No	No	0	4	4
69	L:L:?1	R:R:N250	28.8756	5.41	Yes	No	1	0	5
70	R:R:M174	R:R:N250	34.4598	7.01	No	No	0	3	5
71	R:R:L236	R:R:Y197	10.4609	4.69	No	Yes	2	7	9
72	R:R:I200	R:R:I204	34.8719	1.47	Yes	No	0	9	8
73	R:R:I204	R:R:T228	27.9277	3.04	No	No	0	8	7
74	R:R:F201	R:R:T228	24.7819	5.19	No	No	0	5	7
75	R:R:E225	R:R:F201	17.7622	5.83	No	No	0	7	5
76	R:R:E225	R:R:R205	14.2455	8.14	No	No	0	7	5
77	R:R:I253	R:R:M174	32.3717	2.92	No	No	0	4	3
78	R:R:I253	R:R:V259	30.2974	6.14	No	Yes	0	4	4
79	R:R:I249	R:R:V259	19.9258	3.07	No	Yes	0	5	4
80	R:R:G267	R:R:I249	17.8721	1.76	No	No	0	6	5
81	R:R:G267	R:R:L270	13.7784	1.71	No	No	0	6	7
82	R:R:M276	R:R:M277	20.4616	2.89	Yes	No	0	6	6
83	R:R:L238	R:R:M277	17.2883	8.48	No	No	0	6	6
84	R:R:L234	R:R:L238	14.1218	1.38	No	No	0	6	6
85	R:R:I104	R:R:R108	22.1581	3.76	Yes	Yes	2	8	9
86	R:R:D58	R:R:L54	59.3722	4.07	Yes	Yes	2	9	9
87	R:R:L101	R:R:L54	11.9514	6.92	No	Yes	2	8	9
88	R:R:I104	R:R:Y282	22.5977	7.25	Yes	Yes	2	8	9
89	R:R:R108	R:R:Y197	20.0769	6.17	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L91	5.45	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:T94	13.55	1	Yes	No	0	6	0	1
L:L:?1	R:R:H95	3.38	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q167	3.5	1	Yes	No	0	5	0	1
L:L:?1	R:R:F168	47.99	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V169	4.89	1	Yes	No	0	4	0	1
L:L:?1	R:R:M177	8.36	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L246	7.27	1	Yes	No	0	6	0	1
L:L:?1	R:R:N250	5.41	1	Yes	No	0	5	0	1
L:L:?1	R:R:L264	11.82	1	Yes	No	0	4	0	1
L:L:?1	R:R:I268	15.94	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:S271	2.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:H272	9.29	1	Yes	Yes	0	7	0	1
R:R:E19	R:R:Y15	17.96	1	Yes	Yes	5	4	2	2
R:R:I268	R:R:Y15	6.04	1	Yes	Yes	5	4	1	2
R:R:E19	R:R:H272	12.31	1	Yes	Yes	5	7	2	1
R:R:H272	R:R:V65	4.15	1	Yes	Yes	7	7	1	2
R:R:F168	R:R:T87	3.89	1	Yes	Yes	5	4	1	2
R:R:M172	R:R:T87	9.03	1	Yes	Yes	4	4	2	2
R:R:L91	R:R:M172	5.65	1	Yes	Yes	4	4	1	2
R:R:L91	R:R:Y176	3.52	1	Yes	Yes	4	6	1	2
R:R:L91	R:R:M177	8.48	1	Yes	Yes	4	5	1	1
R:R:T94	R:R:W243	4.85	0	No	Yes	6	8	1	2
R:R:H95	R:R:V141	8.3	1	Yes	No	6	4	1	2
R:R:H95	R:R:S181	8.37	1	Yes	No	6	5	1	2
R:R:H95	R:R:W185	5.29	1	Yes	Yes	6	5	1	2
R:R:V141	R:R:W185	9.81	1	No	Yes	4	5	2	2
R:R:F168	R:R:M172	8.71	1	Yes	Yes	5	4	1	2
R:R:F168	R:R:M177	7.46	1	Yes	Yes	5	5	1	1
R:R:M174	R:R:N250	7.01	0	No	No	3	5	2	1
R:R:M177	R:R:N250	4.21	1	Yes	No	5	5	1	1
R:R:I268	R:R:L246	5.71	1	Yes	No	5	6	1	1
R:R:L246	R:R:S271	3	1	No	Yes	6	7	1	1
R:R:I268	R:R:S271	3.1	1	Yes	Yes	5	7	1	1
R:R:H272	R:R:I268	5.3	1	Yes	Yes	7	5	1	1
R:R:H272	R:R:S271	4.18	1	Yes	Yes	7	7	1	1
R:R:Q167	R:R:S165	2.89	0	No	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X17_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	260
Number of Links	310
Number of Hubs	48
Number of Links mediated by Hubs	175
Number of Communities	8
Number of Nodes involved in Communities	78
Number of Links involved in Communities	115

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	45641
Length Of Smallest Path	3
Average Path Length	12.5299
Length of Longest Path	29
Minimum Path Strength	1.22
Average Path Strength	6.47184
Maximum Path Strength	31.965
Minimum Path Correlation	0.7
Average Path Correlation	0.919695
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.8108
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.8055
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • magnesium ion binding • ion binding • binding • metal ion binding • small molecule binding • guanyl nucleotide binding • nucleotide binding • GDP binding • guanyl ribonucleotide binding • purine ribonucleotide binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • G protein-coupled serotonin receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • GTP binding • purine ribonucleoside triphosphate binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of cellular process • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of biological process
Gene Ontology	Biological Process	• regulation of cytoskeleton organization • regulation of cellular component organization • regulation of cellular process • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of biological process • regulation of cell cycle process • biological regulation • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • cellular process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • regulation of protein localization • positive regulation of biological process • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of protein localization to cell cortex • macromolecule localization • positive regulation of protein localization • intracellular protein localization • protein localization to cell cortex • cell division • cellular response to stimulus • response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to lipid • response to alcohol • cellular response to forskolin • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to chemical • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • membrane-bounded organelle • nucleus • intracellular membrane-bounded organelle • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled adenosine receptor activity • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • negative regulation of locomotion • regulation of cell motility • negative regulation of biological process • regulation of locomotion • negative regulation of cellular process • regulation of cell migration • negative regulation of cell motility • cell migration • cell motility • negative regulation of cell migration • locomotion • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • response to stress • response to wounding • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • defense response • inflammatory response • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • monoamine transport • regulation of localization • nitrogen compound transport • transport • regulation of catecholamine secretion • organic hydroxy compound transport • localization • secretion by cell • regulation of secretion by cell • catecholamine transport • signal release • norepinephrine transport • secretion • regulation of transport • export from cell • establishment of localization • organic cation transport • regulation of secretion • catecholamine secretion • amine transport • norepinephrine secretion • regulation of amine transport • regulation of norepinephrine secretion • negative regulation of DNA-binding transcription factor activity • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • negative regulation of NF-kappaB transcription factor activity • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • negative regulation of molecular function • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • regulation of DNA-binding transcription factor activity • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • synapse • cell junction • Schaffer collateral - CA1 synapse • presynapse • presynaptic membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • organelle membrane • cell projection membrane • cell body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	XS0
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	XS0
Name	Namodenoson
Synonyms	(2~{S},3~{S},4~{R},5~{R})-5-[2-chloranyl-6-[(3-iodanylphenyl)methylamino]purin-9-yl]-~{N}-methyl-3,4-bis(oxidanyl)oxolane-2-carboxamide; CF102; Cl-IB-MECA
Identifier
Formula	C18 H18 Cl I N6 O4
Molecular Weight	544.731
SMILES
PubChem	3035850
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	4
Total Bonds	51
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P0DMS8
Sequence	>8X17_nogp_Chain_R A L S L A N V T Y I T M E I F I G L C A I V G N V L V I C V V K L N P S L Q T T T F Y F I V S L A L A D I A V G V L V M P L A I V V S L G I T I H F Y S C L F M T C L L L I F T H A S I M S L L A I A V D R Y L R V K L T V R Y K R V T T H R R I W L A L G L C W L V S F L V G L T P M F G W N M K L T S E Y H R N V T F L S C Q F V S V M R M D Y M V Y F S F L T W I F I P L V V M C A I Y L D I F Y I I R N K L S L G R E F K T A K S L F L V L F L F A L S W L P L S I I N C I I Y F N G E V P Q L V L Y M G I L L S H A N S M M N P I V Y A Y K I K K F K E T Y L L I L K A C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8X16	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	Gi1/β1/γ2	3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X16 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8YH0	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-	Gi1/β1/γ2	2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH0 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-		2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-	Gi1/β1/γ2	3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-		3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	9EHS	A	Nucleotide	Adenosine	A_3A	Homo sapiens	LUF7602	-	-	3.2	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	chim(NtGi1L-Gs-CtGi1)/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBH	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBH (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x

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