Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.69851310
2R:R:Y15 11.274514
3R:R:E19 7.256515
4R:R:N30 6.52409
5R:R:L43 6.845468
6R:R:F48 6.225409
7R:R:L54 6.168519
8R:R:D58 7.8525419
9R:R:M66 5.3175406
10R:R:H79 6.12427
11R:R:F80 7.614523
12R:R:L84 6.145426
13R:R:L91 5.145414
14R:R:F93 7.154506
15R:R:H95 5.815406
16R:R:L101 5.96418
17R:R:L102 4.0225407
18R:R:Y109 6.84408
19R:R:R111 10.6275438
20R:R:Y118 10.29538
21R:R:P145 6.05415
22R:R:M146 3.88505
23R:R:N150 4.076525
24R:R:K152 5.4525424
25R:R:L164 3.825404
26R:R:V171 6.3875425
27R:R:Y176 7.215616
28R:R:M177 5.595415
29R:R:W185 9.6375405
30R:R:Y197 7.09619
31R:R:F239 7.98418
32R:R:W243 6.87571718
33R:R:Y254 8.06504
34R:R:V259 4.712544
35R:R:Y265 13.695404
36R:R:I268 8.35415
37R:R:N274 5.995419
38R:R:N278 8.525419
39R:R:V281 4.5425408
40R:R:Y282 7.372519
41R:R:T292 7.075467
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:I268 22.93579.37YesYes105
2R:R:I268 R:R:Y15 14.118713.3YesYes154
3R:R:E19 R:R:L269 12.5445.3YesNo155
4L:L:?1 R:R:L91 37.73295.45YesYes104
5R:R:L91 R:R:Y176 37.07027.03YesYes146
6R:R:P145 R:R:Y176 69.278.34YesYes156
7R:R:C88 R:R:P145 1005.65NoYes065
8R:R:C88 R:R:M146 98.83884.86NoYes065
9R:R:F85 R:R:M146 40.15634.98NoYes055
10R:R:F85 R:R:L89 38.805110.96NoNo055
11R:R:F93 R:R:L89 29.73693.65YesNo065
12R:R:F93 R:R:L64 21.48177.31YesNo064
13R:R:L64 R:R:V63 20.07722.98NoNo044
14R:R:I27 R:R:V63 18.66863.07NoNo064
15R:R:G62 R:R:I27 15.83983.53NoNo066
16R:R:G23 R:R:G62 14.41942.11NoNo066
17R:R:G23 R:R:M66 12.99515.24NoYes066
18L:L:?1 R:R:M177 36.6354.64YesYes105
19R:R:M177 R:R:Y176 36.47874.79YesYes156
20L:L:?1 R:R:F168 34.199839.19YesNo105
21R:R:F168 R:R:M172 346.22NoNo154
22R:R:M172 R:R:P145 33.78246.71NoYes145
23R:R:L269 R:R:V18 16.259111.92NoNo054
24R:R:I22 R:R:V18 10.85463.07NoNo074
25L:L:?1 R:R:W243 89.16723.74YesYes108
26R:R:N274 R:R:W243 86.22354.52YesYes198
27R:R:N274 R:R:N278 87.06829.54YesYes199
28R:R:D58 R:R:N278 12.39968.08YesYes199
29R:R:D58 R:R:N30 11.471810.77YesYes099
30R:R:L54 R:R:N278 32.22356.87YesYes199
31R:R:L54 R:R:S100 41.32346.01YesNo097
32R:R:S100 R:R:S53 40.43133.26NoNo079
33R:R:L131 R:R:S53 39.53316.01NoNo079
34R:R:F50 R:R:L131 37.71124.87NoNo087
35R:R:D107 R:R:F50 34.953514.33NoNo098
36R:R:D107 R:R:R111 26.43929.53NoYes398
37R:R:R111 R:R:T47 20.85065.17YesNo088
38R:R:F48 R:R:T47 19.88725.19YesNo098
39R:R:F48 R:R:L43 16.955514.61YesYes098
40R:R:L43 R:R:T292 11.94074.42YesYes687
41R:R:L101 R:R:N278 45.60249.61YesYes189
42R:R:L84 R:R:M146 60.19784.24YesYes065
43R:R:L84 R:R:N150 32.93185.49YesYes265
44R:R:F80 R:R:N150 17.83194.83YesYes235
45R:R:F80 R:R:L164 19.16324.87YesYes034
46R:R:L84 R:R:V171 24.658810.43YesYes265
47R:R:F80 R:R:V171 17.95255.24YesYes235
48R:R:F80 R:R:Y81 13.954514.44YesNo231
49R:R:H79 R:R:Y81 16.73393.27YesNo271
50R:R:K152 R:R:N150 11.08016.99YesYes245
51R:R:L101 R:R:M193 24.89422.83YesNo088
52R:R:L102 R:R:M193 24.05742.83YesNo078
53R:R:L102 R:R:V192 15.7277.45YesNo076
54R:R:L101 R:R:Y282 27.75475.86YesYes189
55R:R:Y197 R:R:Y282 21.0924.96YesYes199
56R:R:A105 R:R:Y197 20.05544NoYes089
57R:R:A105 R:R:I196 19.00493.25NoNo086
58R:R:I196 R:R:Y109 31.66573.63NoYes068
59R:R:I196 R:R:V192 14.913.07NoNo066
60R:R:D199 R:R:Y109 17.95055.75NoYes048
61R:R:D199 R:R:I203 15.96044.2NoNo045
62R:R:I203 R:R:Y202 14.01382.42NoNo053
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L91 5.45 1 Yes Yes 0 4 0 1
L:L:?1 R:R:T94 5.81 1 Yes No 0 6 0 1
L:L:?1 R:R:F168 39.19 1 Yes No 0 5 0 1
L:L:?1 R:R:R169 10.37 1 Yes No 0 4 0 1
L:L:?1 R:R:M174 8.36 1 Yes No 0 3 0 1
L:L:?1 R:R:M177 4.64 1 Yes Yes 0 5 0 1
L:L:?1 R:R:W243 3.74 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L246 9.09 1 Yes No 0 6 0 1
L:L:?1 R:R:N250 15.33 1 Yes No 0 5 0 1
L:L:?1 R:R:L253 10 1 Yes No 0 4 0 1
L:L:?1 R:R:L264 11.82 1 Yes No 0 4 0 1
L:L:?1 R:R:I268 9.37 1 Yes Yes 0 5 0 1
L:L:?1 R:R:H272 5.91 1 Yes No 0 7 0 1
R:R:E19 R:R:Y15 7.86 1 Yes Yes 5 4 2 2
R:R:I268 R:R:Y15 13.3 1 Yes Yes 5 4 1 2
R:R:E19 R:R:I268 4.1 1 Yes Yes 5 5 2 1
R:R:E19 R:R:H272 16 1 Yes No 5 7 2 1
R:R:H95 R:R:L91 3.86 0 Yes Yes 6 4 2 1
R:R:L91 R:R:Y176 7.03 1 Yes Yes 4 6 1 2
R:R:L91 R:R:M177 4.24 1 Yes Yes 4 5 1 1
R:R:H95 R:R:T94 4.11 0 Yes No 6 6 2 1
R:R:T94 R:R:W243 3.64 1 No Yes 6 8 1 1
R:R:F239 R:R:I98 7.54 1 Yes No 8 8 2 2
R:R:I98 R:R:W243 10.57 1 No Yes 8 8 2 1
R:R:M151 R:R:R169 4.96 0 No No 4 4 2 1
R:R:F168 R:R:M172 6.22 1 No No 5 4 1 2
R:R:F168 R:R:M177 8.71 1 No Yes 5 5 1 1
R:R:M174 R:R:R169 8.69 1 No No 3 4 1 1
R:R:M172 R:R:Y176 5.99 1 No Yes 4 6 2 2
R:R:M174 R:R:Y254 4.79 1 No Yes 3 4 1 2
R:R:M177 R:R:Y176 4.79 1 Yes Yes 5 6 1 2
R:R:I186 R:R:W243 3.52 0 No Yes 7 8 2 1
R:R:F239 R:R:W243 11.02 1 Yes Yes 8 8 2 1
R:R:F239 R:R:N274 3.62 1 Yes Yes 8 9 2 2
R:R:S271 R:R:W243 11.12 0 No Yes 7 8 2 1
R:R:N274 R:R:W243 4.52 1 Yes Yes 9 8 2 1
R:R:G267 R:R:L246 5.13 0 No No 6 6 2 1
R:R:L246 R:R:S271 6.01 0 No No 6 7 1 2
R:R:L253 R:R:V259 4.47 0 No Yes 4 4 1 2
R:R:L264 R:R:Q261 7.99 0 No No 4 2 1 2
R:R:H272 R:R:I268 6.63 1 No Yes 7 5 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8YH6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.26
Number of Linked Nodes 253
Number of Links 291
Number of Hubs 41
Number of Links mediated by Hubs 155
Number of Communities 7
Number of Nodes involved in Communities 60
Number of Links involved in Communities 86
Path Summary
Number Of Nodes in MetaPath 63
Number Of Links MetaPath 62
Number of Shortest Paths 85854
Length Of Smallest Path 3
Average Path Length 15.9232
Length of Longest Path 37
Minimum Path Strength 1.33
Average Path Strength 6.60992
Maximum Path Strength 27.26
Minimum Path Correlation 0.7
Average Path Correlation 0.919835
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.94118
Average % Of Corr. Nodes 36.2876
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.321
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• bioluminescence   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • viral process   • fusion of virus membrane with host endosome membrane   • membrane fusion involved in viral entry into host cell   • membrane organization   • cellular component organization   • membrane fusion   • fusion of virus membrane with host plasma membrane   • cellular component organization or biogenesis   • virion attachment to host cell   • biological process involved in interspecies interaction between organisms   • adhesion of symbiont to host cell   • viral life cycle   • adhesion of symbiont to host   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • non-lytic viral release   • viral budding   • virion assembly   • exit from host cell   • viral budding from plasma membrane   • viral release from host cell   • import into cell   • receptor-mediated endocytosis of virus by host cell   • transport   • establishment of localization   • vesicle-mediated transport   • localization   • symbiont entry into host cell   • clathrin-dependent endocytosis   • symbiont entry into host   • clathrin-dependent endocytosis of virus by host cell   • receptor-mediated endocytosis   • endocytosis   • endocytosis involved in viral entry into host cell   • cellular anatomical structure   • membrane   • virion component   • virion membrane   • viral membrane   • viral envelope   • host cell plasma membrane   • host cellular component   • host cell part   • host cell membrane   • other organism part   • cell periphery   • plasma membrane   • somatodendritic compartment
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • virion component   • virion membrane   • viral membrane   • viral envelope   • host cell plasma membrane   • host cellular component   • host cell part   • host cell membrane   • other organism part   • cell periphery   • plasma membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • cation binding   • magnesium ion binding   • ion binding   • metal ion binding   • small molecule binding   • guanyl nucleotide binding   • nucleotide binding   • GDP binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • nucleoside phosphate binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • G protein-coupled serotonin receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • GTP binding   • purine ribonucleoside triphosphate binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • regulation of protein localization   • positive regulation of biological process   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of protein localization to cell cortex   • macromolecule localization   • positive regulation of protein localization   • intracellular protein localization   • protein localization to cell cortex   • cell division   • cellular response to forskolin   • response to forskolin   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • midbody   • cell cortex   • intracellular anatomical structure   • cytoplasm   • intracellular organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • intracellular membraneless organelle   • microtubule cytoskeleton   • nucleus   • intracellular membrane-bounded organelle   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • phospholipase C-activating G protein-coupled receptor signaling pathway   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeXS0
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeXS0
NameNamodenoson
Synonyms(2~{S},3~{S},4~{R},5~{R})-5-[2-chloranyl-6-[(3-iodanylphenyl)methylamino]purin-9-yl]-~{N}-methyl-3,4-bis(oxidanyl)oxolane-2-carboxamide; CF102; Cl-IB-MECA
Identifier
FormulaC18 H18 Cl I N6 O4
Molecular Weight544.731
SMILES
PubChem3035850
Formal Charge0
Total Atoms48
Total Chiral Atoms4
Total Bonds51
Total Aromatic Bonds16

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP0DMS8
Sequence
>8YH6_nogp_Chain_R
SVTYITEII GLCAIVGNV LVIVVKLNP SLQTTTFYF IVSLALADI 
AVGVLVMPL AIVSLGTIH FYSCLFMTC LLIFTHASI MSLLAIAVD 
RYLRVKLTV RYRVTTRRI WLALGLCWL VSFLVGLTP MFGWNMKLS 
NTFLCFSVM RMDYMVYFS FWIPLVVMC AIYDIFYII RNLEFKTAK 
SLLVLFLFA LWLPLSIIN CIYFGVPQV LYGILLSHA NSMMNPIVY 
AYKIKKFKE TYLLIWTSV LWIVMRQSA DELPRRFLL VFRLCLDQT 
L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8X16ANucleotideAdenosineA3AHomo sapiensPiclidenoson-Gi1/β1/γ23.292024-04-24doi.org/10.1038/s41467-024-47207-6
8X16 (No Gprot) ANucleotideAdenosineA3AHomo sapiensPiclidenoson-3.292024-04-24doi.org/10.1038/s41467-024-47207-6
8X17ANucleotideAdenosineA3AHomo sapiensNamodenoson-Gi1/β1/γ23.192024-04-24doi.org/10.1038/s41467-024-47207-6
8X17 (No Gprot) ANucleotideAdenosineA3AHomo sapiensNamodenoson-3.192024-04-24doi.org/10.1038/s41467-024-47207-6
8YH0ANucleotideAdenosineA3AHomo sapiensNECA-Gi1/β1/γ22.862024-11-06doi.org/10.1038/s41467-024-53473-1
8YH0 (No Gprot) ANucleotideAdenosineA3AHomo sapiensNECA-2.862024-11-06doi.org/10.1038/s41467-024-53473-1
8YH2ANucleotideAdenosineA3AHomo sapiensAdenosine-Gi1/β1/γ23.272024-11-06doi.org/10.1038/s41467-024-53473-1
8YH2 (No Gprot) ANucleotideAdenosineA3AHomo sapiensAdenosine-3.272024-11-06doi.org/10.1038/s41467-024-53473-1
8YH3ANucleotideAdenosineA3AHomo sapiensN-methyladenosine-Gi1/β1/γ23.42024-11-06doi.org/10.1038/s41467-024-53473-1
8YH3 (No Gprot) ANucleotideAdenosineA3AHomo sapiensN-methyladenosine-3.42024-11-06doi.org/10.1038/s41467-024-53473-1
8YH5ANucleotideAdenosineA3AHomo sapiensRiboprine-Gi1/β1/γ23.662024-11-06doi.org/10.1038/s41467-024-53473-1
8YH5 (No Gprot) ANucleotideAdenosineA3AHomo sapiensRiboprine-3.662024-11-06doi.org/10.1038/s41467-024-53473-1
8YH6ANucleotideAdenosineA3AHomo sapiensNamodenoson-Gi1/β1/γ23.622024-11-06doi.org/10.1038/s41467-024-53473-1
8YH6 (No Gprot) ANucleotideAdenosineA3AHomo sapiensNamodenoson-3.622024-11-06doi.org/10.1038/s41467-024-53473-1
9EHSANucleotideAdenosineA3AHomo sapiensLUF7602--3.22025-08-20doi.org/10.1038/s41467-025-62872-x
9EBIANucleotideAdenosineA3AHomo sapiensPiclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ23.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBI (No Gprot) ANucleotideAdenosineA3AHomo sapiensPiclidenoson-3.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBHANucleotideAdenosineA3AHomo sapiensAdenosine-Gi1/β1/γ23.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBH (No Gprot) ANucleotideAdenosineA3AHomo sapiensAdenosine-3.62025-08-20doi.org/10.1038/s41467-025-62872-x




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