Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.97556910
2R:R:N12 5.5675413
3R:R:Y15 6.464514
4R:R:N30 5.9525409
5R:R:N40 3.93405
6R:R:F48 7.735409
7R:R:D58 6.28409
8R:R:V65 4.98407
9R:R:S73 3.255415
10R:R:I78 3.5375475
11R:R:I92 6.8925445
12R:R:F93 7.058546
13R:R:L101 5.545428
14R:R:Y118 5.37143738
15R:R:W135 3.228549
16R:R:V141 4.47454
17R:R:M146 2.59405
18R:R:K152 6.3775404
19R:R:V171 3.06505
20R:R:R173 7.1725404
21R:R:Y176 7.246556
22R:R:W185 7.21555
23R:R:Y197 5.435409
24R:R:F201 4.09405
25R:R:W243 6.205408
26R:R:Y254 6.29484
27R:R:V259 3.1875404
28R:R:S271 4.4375417
29R:R:H272 7.2475417
30R:R:N274 5.725429
31R:R:N278 8.5325429
32R:R:Y282 5.768529
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:H272 14.81446.79YesYes107
2L:L:?1 R:R:T94 49.26653.89YesNo006
3R:R:T94 R:R:W243 38.24724.85NoYes068
4R:R:N274 R:R:W243 67.6154.52YesYes098
5R:R:L101 R:R:N274 46.06634.12YesYes289
6R:R:L101 R:R:Y282 46.47817.03YesYes289
7R:R:V235 R:R:Y282 45.99095.05NoYes089
8R:R:V235 R:R:V281 15.28283.21NoNo088
9R:R:I280 R:R:V281 11.55223.07NoNo068
10R:R:I280 R:R:M277 10.28992.92NoNo066
11L:L:?1 R:R:S271 37.69013.97YesYes107
12R:R:S271 R:R:W243 41.01693.71YesYes078
13R:R:T94 R:R:V65 12.33013.17NoYes067
14R:R:V61 R:R:V65 21.09129.62NoYes087
15R:R:S275 R:R:V61 19.44933.23NoNo098
16R:R:H272 R:R:V65 12.29244.15YesYes077
17R:R:D58 R:R:S275 17.89365.89YesNo099
18R:R:D58 R:R:N30 33.79548.08YesYes099
19R:R:I59 R:R:N30 11.51722.83NoYes079
20R:R:N274 R:R:N278 19.76426.81YesYes299
21R:R:D58 R:R:N278 22.50426.73YesYes099
22R:R:A55 R:R:N30 11.15933.13NoYes099
23L:L:?1 R:R:F168 10031.36YesNo105
24R:R:F168 R:R:M172 77.78919.95NoNo154
25R:R:M172 R:R:P145 77.64383.35NoNo045
26R:R:C88 R:R:P145 78.79043.77NoNo065
27R:R:C88 R:R:L143 78.32483.17NoNo064
28R:R:I92 R:R:L143 77.74615.71YesNo054
29R:R:F93 R:R:I92 40.804210.05YesYes465
30R:R:F93 R:R:W135 35.71723.01YesYes469
31R:R:S53 R:R:W135 64.36364.94NoYes099
32R:R:L131 R:R:S53 61.13379.01NoNo079
33R:R:F50 R:R:L131 57.88236.09NoNo087
34R:R:D107 R:R:F50 54.585117.91NoNo098
35R:R:D107 R:R:R111 37.69017.15NoNo398
36R:R:R111 R:R:T47 36.511210.35NoNo088
37R:R:F48 R:R:T47 33.24093.89YesNo098
38R:R:F48 R:R:L43 28.334217.05YesNo098
39R:R:L43 R:R:N40 24.86746.87NoYes085
40R:R:N40 R:R:T292 17.86945.85YesNo057
41R:R:T292 R:R:V36 16.10644.76NoNo078
42R:R:F289 R:R:V36 14.3386.55NoNo088
43R:R:F139 R:R:I92 35.765610.05NoYes445
44R:R:F139 R:R:W135 35.03893.01NoYes449
45R:R:D107 R:R:Y118 15.42275.75NoYes398
46R:R:F168 R:R:T87 21.89335.19NoNo154
47R:R:T87 R:R:V171 21.36843.17NoYes045
48R:R:L84 R:R:V171 11.72724.47NoYes065
49R:R:L84 R:R:M146 12.67734.24NoYes065
50R:R:L84 R:R:P145 13.34218.21NoNo065
51R:R:F80 R:R:V171 10.45952.62NoYes035
52R:R:I98 R:R:W243 17.279911.74NoYes088
53R:R:H95 R:R:I98 13.84813.98NoNo068
54R:R:H95 R:R:I186 12.70153.98NoNo067
55L:L:?1 R:R:N250 33.9736.35YesNo005
56R:R:M177 R:R:N250 22.38317.01NoNo055
57R:R:M177 R:R:S181 21.47073.07NoNo055
58R:R:S181 R:R:Y176 20.5695.09NoYes056
59R:R:V235 R:R:Y197 31.38917.57NoYes089
60R:R:L232 R:R:Y197 25.65073.52NoYes089
61R:R:I200 R:R:L232 14.8444.28NoNo098
62R:R:M174 R:R:N250 12.52124.21NoNo035
63R:R:I253 R:R:M174 10.54025.83NoNo043
64R:R:F182 R:R:I186 11.67075.02NoNo057
65R:R:F201 R:R:L232 10.27911.22YesNo058
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:T94 3.89 1 Yes No 0 6 0 1
L:L:?1 R:R:F168 31.36 1 Yes No 0 5 0 1
L:L:?1 R:R:L246 6.4 1 Yes No 0 6 0 1
L:L:?1 R:R:N250 6.35 1 Yes No 0 5 0 1
L:L:?1 R:R:I268 7.54 1 Yes No 0 5 0 1
L:L:?1 R:R:S271 3.97 1 Yes Yes 0 7 0 1
L:L:?1 R:R:H272 6.79 1 Yes Yes 0 7 0 1
R:R:I268 R:R:Y15 7.25 1 No Yes 5 4 1 2
R:R:E19 R:R:H272 11.08 0 No Yes 5 7 2 1
R:R:T94 R:R:V65 3.17 0 No Yes 6 7 1 2
R:R:H272 R:R:V65 4.15 1 Yes Yes 7 7 1 2
R:R:F168 R:R:T87 5.19 1 No No 5 4 1 2
R:R:M172 R:R:T87 3.01 1 No No 4 4 2 2
R:R:T94 R:R:W243 4.85 0 No Yes 6 8 1 2
R:R:F168 R:R:M172 9.95 1 No No 5 4 1 2
R:R:M174 R:R:N250 4.21 0 No No 3 5 2 1
R:R:M177 R:R:N250 7.01 0 No No 5 5 2 1
R:R:S271 R:R:W243 3.71 1 Yes Yes 7 8 1 2
R:R:I268 R:R:S271 3.1 1 No Yes 5 7 1 1
R:R:H272 R:R:S271 6.97 1 Yes Yes 7 7 1 1
L:L:?1 R:R:L91 2.74 1 Yes No 0 4 0 1
L:L:?1 R:R:L264 2.74 1 Yes No 0 4 0 1
R:R:G267 R:R:L246 1.71 0 No No 6 6 2 1
R:R:L264 R:R:Q261 1.33 0 No No 4 2 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9EBH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.01
Number of Linked Nodes 241
Number of Links 263
Number of Hubs 32
Number of Links mediated by Hubs 125
Number of Communities 8
Number of Nodes involved in Communities 42
Number of Links involved in Communities 53
Path Summary
Number Of Nodes in MetaPath 66
Number Of Links MetaPath 65
Number of Shortest Paths 58648
Length Of Smallest Path 3
Average Path Length 17.0977
Length of Longest Path 38
Minimum Path Strength 1.24
Average Path Strength 6.62503
Maximum Path Strength 19.45
Minimum Path Correlation 0.7
Average Path Correlation 0.920782
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 36.7978
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.5397
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled adenosine receptor activity   • heart process   • multicellular organismal process   • system process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • negative regulation of locomotion   • regulation of cell motility   • negative regulation of biological process   • regulation of locomotion   • negative regulation of cellular process   • regulation of cell migration   • negative regulation of cell motility   • cell migration   • cell motility   • negative regulation of cell migration   • locomotion   • negative regulation of cell population proliferation   • regulation of cell population proliferation   • response to stress   • response to wounding   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • defense response   • inflammatory response   • purinergic nucleotide receptor signaling pathway   • cell surface receptor signaling pathway   • G protein-coupled purinergic receptor signaling pathway   • G protein-coupled adenosine receptor signaling pathway   • monoamine transport   • regulation of localization   • nitrogen compound transport   • transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • localization   • secretion by cell   • regulation of secretion by cell   • catecholamine transport   • signal release   • norepinephrine transport   • secretion   • regulation of transport   • export from cell   • establishment of localization   • organic cation transport   • regulation of secretion   • catecholamine secretion   • amine transport   • norepinephrine secretion   • regulation of amine transport   • regulation of norepinephrine secretion   • negative regulation of DNA-binding transcription factor activity   • RNA metabolic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • negative regulation of NF-kappaB transcription factor activity   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • negative regulation of molecular function   • primary metabolic process   • regulation of macromolecule metabolic process   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • regulation of gene expression   • biosynthetic process   • regulation of DNA-binding transcription factor activity   • metabolic process   • regulation of macromolecule biosynthetic process   • regulation of DNA-templated transcription   • macromolecule metabolic process   • regulation of metabolic process   • Schaffer collateral - CA1 synapse   • presynapse   • presynaptic membrane   • plasma membrane region   • synaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • T cell migration   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • establishment of protein localization   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • amide transport   • negative regulation of protein localization   • regulation of peptide transport   • regulation of establishment of protein localization   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeADN
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeADN
NameAdenosine
SynonymsAdo
Identifier
FormulaC10 H13 N5 O4
Molecular Weight267.241
SMILES
PubChem60961
Formal Charge0
Total Atoms32
Total Chiral Atoms4
Total Bonds34
Total Aromatic Bonds10

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP0DMS8
Sequence
>9EBH_nogp_Chain_R
SLANVTYIT MEIFIGLCA IVGNVLVIC VVKLNPSLQ TTTFYFIVS 
LALADIAVG VLVMPLAIV VSLGITIHF YSCLFMTCL LLIFTHASI 
MSLLAIAVD RYLRVKLTV RYKRVTTHR RIWLALGLC WLVSFLVGL 
TPMFGWNMK LTSEYHRNV TFLSCQFVS VMRMDYMVY FSFLTWIFI 
PLVVMCAIY LDIFYIIRN FKTAKSLFL VLFLFALSW LPLSIINCI 
IYFNGEVPQ LVLYMGILL SHANSMMNP IVYAYKIKK FKETY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8X16ANucleotideAdenosineA3AHomo sapiensPiclidenoson-Gi1/β1/γ23.292024-04-24doi.org/10.1038/s41467-024-47207-6
8X16 (No Gprot) ANucleotideAdenosineA3AHomo sapiensPiclidenoson-3.292024-04-24doi.org/10.1038/s41467-024-47207-6
8X17ANucleotideAdenosineA3AHomo sapiensNamodenoson-Gi1/β1/γ23.192024-04-24doi.org/10.1038/s41467-024-47207-6
8X17 (No Gprot) ANucleotideAdenosineA3AHomo sapiensNamodenoson-3.192024-04-24doi.org/10.1038/s41467-024-47207-6
8YH0ANucleotideAdenosineA3AHomo sapiensNECA-Gi1/β1/γ22.862024-11-06doi.org/10.1038/s41467-024-53473-1
8YH0 (No Gprot) ANucleotideAdenosineA3AHomo sapiensNECA-2.862024-11-06doi.org/10.1038/s41467-024-53473-1
8YH2ANucleotideAdenosineA3AHomo sapiensAdenosine-Gi1/β1/γ23.272024-11-06doi.org/10.1038/s41467-024-53473-1
8YH2 (No Gprot) ANucleotideAdenosineA3AHomo sapiensAdenosine-3.272024-11-06doi.org/10.1038/s41467-024-53473-1
8YH3ANucleotideAdenosineA3AHomo sapiensN-methyladenosine-Gi1/β1/γ23.42024-11-06doi.org/10.1038/s41467-024-53473-1
8YH3 (No Gprot) ANucleotideAdenosineA3AHomo sapiensN-methyladenosine-3.42024-11-06doi.org/10.1038/s41467-024-53473-1
8YH5ANucleotideAdenosineA3AHomo sapiensRiboprine-Gi1/β1/γ23.662024-11-06doi.org/10.1038/s41467-024-53473-1
8YH5 (No Gprot) ANucleotideAdenosineA3AHomo sapiensRiboprine-3.662024-11-06doi.org/10.1038/s41467-024-53473-1
8YH6ANucleotideAdenosineA3AHomo sapiensNamodenoson-Gi1/β1/γ23.622024-11-06doi.org/10.1038/s41467-024-53473-1
8YH6 (No Gprot) ANucleotideAdenosineA3AHomo sapiensNamodenoson-3.622024-11-06doi.org/10.1038/s41467-024-53473-1
9EHSANucleotideAdenosineA3AHomo sapiensLUF7602--3.22025-08-20doi.org/10.1038/s41467-025-62872-x
9EBIANucleotideAdenosineA3AHomo sapiensPiclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ23.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBI (No Gprot) ANucleotideAdenosineA3AHomo sapiensPiclidenoson-3.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBHANucleotideAdenosineA3AHomo sapiensAdenosine-Gi1/β1/γ23.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBH (No Gprot) ANucleotideAdenosineA3AHomo sapiensAdenosine-3.62025-08-20doi.org/10.1038/s41467-025-62872-x




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