Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y15 12.138514
2R:R:E19 7.256515
3R:R:N30 6.52409
4R:R:L43 6.4925428
5R:R:L54 5.89519
6R:R:D58 7.8525419
7R:R:M66 4.14506
8R:R:F80 6.19583
9R:R:T87 4.7225414
10R:R:L91 4.414514
11R:R:F93 6.902506
12R:R:H95 6.795416
13R:R:L102 3.8025407
14R:R:R111 11.9375438
15R:R:L114 3.6425405
16R:R:Y118 9.19833638
17R:R:P145 6.675415
18R:R:M146 3.79405
19R:R:N150 4.235485
20R:R:F168 14.74415
21R:R:M172 5.936514
22R:R:Y176 7.698516
23R:R:M177 6.56415
24R:R:Y197 6.73619
25R:R:E225 3.8275407
26R:R:F239 7.98418
27R:R:W243 8.05333618
28R:R:Y254 7.102594
29R:R:V259 4.34254104
30R:R:Y265 14.13404
31R:R:I268 7.685415
32R:R:H272 8.48417
33R:R:N274 6.2775419
34R:R:N278 9.2125419
35R:R:Y282 6.94519
36R:R:T292 7.075427
37R:R:Y293 1.4625407
38L:L:?1 9.711671210
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I268 R:R:Y15 17.945612.09YesYes154
2R:R:G23 R:R:M66 10.77961.75NoYes066
3R:R:G23 R:R:G62 11.93082.11NoNo066
4R:R:G62 R:R:I27 13.07273.53NoNo066
5R:R:I27 R:R:V63 15.32823.07NoNo064
6R:R:L64 R:R:V63 16.44192.98NoNo044
7R:R:F93 R:R:L64 17.54627.31YesNo064
8R:R:F93 R:R:V65 24.1063.93YesNo067
9R:R:H272 R:R:V65 29.42064.15YesNo077
10R:R:E19 R:R:H272 11.879116YesYes157
11R:R:L269 R:R:V18 19.84411.92NoNo054
12R:R:I22 R:R:V18 13.26543.07NoNo074
13R:R:D58 R:R:N278 17.45698.08YesYes199
14R:R:N274 R:R:N278 98.80189.54YesYes199
15R:R:N274 R:R:W243 89.13585.65YesYes198
16L:L:?1 R:R:W243 1006.32YesYes108
17L:L:?1 R:R:I268 26.9167.92YesYes105
18R:R:V36 R:R:Y293 11.13672.52NoYes087
19R:R:T292 R:R:V36 18.76794.76YesNo078
20R:R:L43 R:R:T292 24.23294.42YesYes287
21R:R:F48 R:R:L43 31.558714.61NoYes098
22R:R:F48 R:R:T47 34.44396.49NoNo098
23R:R:R111 R:R:T47 35.85839.06YesNo088
24R:R:D107 R:R:R111 43.033711.91NoYes398
25R:R:D107 R:R:F50 64.169913.14NoNo098
26R:R:F50 R:R:L131 67.89623.65NoNo087
27R:R:L131 R:R:S53 70.36796.01NoNo079
28R:R:S100 R:R:S53 71.57093.26NoNo079
29R:R:L54 R:R:S100 72.75976.01YesNo097
30R:R:L54 R:R:N278 57.52556.87YesYes199
31R:R:D58 R:R:N30 17.066910.77YesYes099
32R:R:A55 R:R:N30 10.24393.13NoYes099
33R:R:D107 R:R:Y118 20.07425.75NoYes398
34R:R:I127 R:R:T46 12.32554.56NoNo065
35R:R:L101 R:R:N278 26.38512.36NoYes189
36R:R:I104 R:R:L54 13.76824.28NoYes189
37R:R:T87 R:R:V171 21.26784.76YesNo045
38R:R:F168 R:R:T87 26.65295.19YesYes154
39L:L:?1 R:R:F168 35.421336.35YesYes105
40R:R:F80 R:R:V171 14.63757.87YesNo035
41R:R:C88 R:R:M146 11.55964.86NoYes065
42R:R:C88 R:R:P145 15.42225.65NoYes065
43R:R:M172 R:R:P145 15.7375.03YesYes145
44L:L:?1 R:R:L91 18.0024.8YesYes104
45R:R:P145 R:R:Y176 14.646912.52YesYes156
46L:L:?1 R:R:M177 10.12645.89YesYes105
47R:R:L102 R:R:P189 30.06444.93YesNo078
48R:R:I98 R:R:P189 33.46653.39NoNo088
49R:R:I98 R:R:W243 25.722510.57NoYes188
50R:R:L101 R:R:Y282 32.1464.69NoYes189
51R:R:L102 R:R:V192 18.04434.47YesNo076
52R:R:Y197 R:R:Y282 24.17653.97YesYes199
53R:R:I196 R:R:Y109 14.46834.84NoNo068
54R:R:I196 R:R:V192 16.26333.07NoNo066
55R:R:D199 R:R:Y109 11.0386.9NoNo048
56R:R:P145 R:R:T144 12.49943.5YesNo055
57R:R:M174 R:R:Y254 12.15643.59NoYes034
58R:R:M174 R:R:N250 14.64224.21NoNo035
59L:L:?1 R:R:N250 15.74648.58YesNo005
60R:R:L232 R:R:Y197 18.998215.24NoYes089
61R:R:V235 R:R:Y282 12.339612.62NoYes189
62R:R:E225 R:R:L208 10.95341.33YesNo074
63R:R:I204 R:R:L208 13.12911.43NoNo084
64R:R:I204 R:R:T228 14.99464.56NoNo087
65R:R:L232 R:R:T228 17.14682.95NoNo087
66R:R:V235 R:R:V281 11.18373.21NoNo188
67L:L:?1 R:R:L246 18.678610.57YesNo006
68R:R:I249 R:R:L246 12.1472.85NoNo056
69R:R:I249 R:R:V263 10.81254.61NoNo054
70R:R:E19 R:R:L269 15.52095.3YesNo155
71L:L:?1 R:R:H272 35.52467.14YesYes107
72R:R:F239 R:R:N274 10.87353.62YesYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E19 R:R:Y15 7.86 1 Yes Yes 5 4 2 2
R:R:I268 R:R:Y15 12.09 1 Yes Yes 5 4 1 2
R:R:E19 R:R:I268 4.1 1 Yes Yes 5 5 2 1
R:R:E19 R:R:H272 16 1 Yes Yes 5 7 2 1
R:R:H272 R:R:V65 4.15 1 Yes No 7 7 1 2
R:R:F168 R:R:T87 5.19 1 Yes Yes 5 4 1 2
R:R:M172 R:R:T87 4.52 1 Yes Yes 4 4 2 2
R:R:H95 R:R:L91 3.86 1 Yes Yes 6 4 1 1
R:R:L91 R:R:M172 4.24 1 Yes Yes 4 4 1 2
R:R:L91 R:R:Y176 3.52 1 Yes Yes 4 6 1 2
R:R:L91 R:R:M177 5.65 1 Yes Yes 4 5 1 1
L:L:?1 R:R:L91 4.8 1 Yes Yes 0 4 0 1
R:R:T94 R:R:W243 3.64 1 No Yes 6 8 1 1
L:L:?1 R:R:T94 11.25 1 Yes No 0 6 0 1
R:R:H95 R:R:V141 6.92 1 Yes No 6 4 1 2
R:R:H95 R:R:S181 8.37 1 Yes No 6 5 1 2
L:L:?1 R:R:H95 8.03 1 Yes Yes 0 6 0 1
R:R:F239 R:R:I98 7.54 1 Yes No 8 8 2 2
R:R:I98 R:R:W243 10.57 1 No Yes 8 8 2 1
R:R:F168 R:R:M172 8.71 1 Yes Yes 5 4 1 2
R:R:F168 R:R:M177 8.71 1 Yes Yes 5 5 1 1
L:L:?1 R:R:F168 36.35 1 Yes Yes 0 5 0 1
R:R:M172 R:R:Y176 7.18 1 Yes Yes 4 6 2 2
R:R:M174 R:R:N250 4.21 0 No No 3 5 2 1
R:R:M177 R:R:Y176 5.99 1 Yes Yes 5 6 1 2
L:L:?1 R:R:M177 5.89 1 Yes Yes 0 5 0 1
R:R:F182 R:R:I186 7.54 0 No No 5 7 2 1
R:R:F239 R:R:W243 11.02 1 Yes Yes 8 8 2 1
R:R:F239 R:R:N274 3.62 1 Yes Yes 8 9 2 2
R:R:S271 R:R:W243 11.12 0 No Yes 7 8 2 1
R:R:N274 R:R:W243 5.65 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W243 6.32 1 Yes Yes 0 8 0 1
R:R:G267 R:R:L246 3.42 0 No No 6 6 2 1
L:L:?1 R:R:L246 10.57 1 Yes No 0 6 0 1
L:L:?1 R:R:N250 8.58 1 Yes No 0 5 0 1
R:R:L264 R:R:Q261 7.99 0 No No 4 2 1 2
L:L:?1 R:R:L264 6.72 1 Yes No 0 4 0 1
R:R:H272 R:R:I268 6.63 1 Yes Yes 7 5 1 1
L:L:?1 R:R:I268 7.92 1 Yes Yes 0 5 0 1
L:L:?1 R:R:H272 7.14 1 Yes Yes 0 7 0 1
L:L:?1 R:R:I186 2.97 1 Yes No 0 7 0 1
R:R:I249 R:R:L246 2.85 0 No No 5 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8YH0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.26
Number of Linked Nodes 250
Number of Links 283
Number of Hubs 38
Number of Links mediated by Hubs 139
Number of Communities 10
Number of Nodes involved in Communities 62
Number of Links involved in Communities 85
Path Summary
Number Of Nodes in MetaPath 73
Number Of Links MetaPath 72
Number of Shortest Paths 45068
Length Of Smallest Path 3
Average Path Length 13.1041
Length of Longest Path 33
Minimum Path Strength 1.08
Average Path Strength 6.91769
Maximum Path Strength 24.475
Minimum Path Correlation 0.7
Average Path Correlation 0.921756
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 46.9465
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.8916
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• bioluminescence   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • viral process   • fusion of virus membrane with host endosome membrane   • membrane fusion involved in viral entry into host cell   • membrane organization   • cellular component organization   • membrane fusion   • fusion of virus membrane with host plasma membrane   • cellular component organization or biogenesis   • virion attachment to host cell   • biological process involved in interspecies interaction between organisms   • adhesion of symbiont to host cell   • viral life cycle   • adhesion of symbiont to host   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • non-lytic viral release   • viral budding   • virion assembly   • exit from host cell   • viral budding from plasma membrane   • viral release from host cell   • import into cell   • receptor-mediated endocytosis of virus by host cell   • transport   • establishment of localization   • vesicle-mediated transport   • localization   • symbiont entry into host cell   • clathrin-dependent endocytosis   • symbiont entry into host   • clathrin-dependent endocytosis of virus by host cell   • receptor-mediated endocytosis   • endocytosis   • endocytosis involved in viral entry into host cell   • cellular anatomical structure   • membrane   • virion component   • virion membrane   • viral membrane   • viral envelope   • host cell plasma membrane   • host cellular component   • host cell part   • host cell membrane   • other organism part   • cell periphery   • plasma membrane   • somatodendritic compartment
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • virion component   • virion membrane   • viral membrane   • viral envelope   • host cell plasma membrane   • host cellular component   • host cell part   • host cell membrane   • other organism part   • cell periphery   • plasma membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • midbody   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • phospholipase C-activating G protein-coupled receptor signaling pathway   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • WD40 repeat-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNEC
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeNEC
NameN-Ethyl-5'-Carboxamido Adenosine
SynonymsN-Ethyl-5'-Carboxamido Adenosine
Identifier
FormulaC12 H16 N6 O4
Molecular Weight308.293
SMILES
PubChem448222
Formal Charge0
Total Atoms38
Total Chiral Atoms4
Total Bonds40
Total Aromatic Bonds10

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP0DMS8
Sequence
>8YH0_nogp_Chain_R
SVTYITEII GLCAIVGNV LVIVVKLNP SLQTTTFYF IVSLALADI 
AVGVLVMPL AIVSLGTIH FYSCLFMTC LLIFTHASI MSLLAIAVD 
RYLRVKLTV RYRVTTRRI WLALGLCWL VSFLVGLTP MFGWNMKLS 
NTFLCFSVM RMDYMVYFS FWIPLVVMC AIYDIFYII RNLEFKTAK 
SLLVLFLFA LWLPLSIIN CIYFGVPQV LYGILLSHA NSMMNPIVY 
AYKIKKFKE TYLLIWTSV LWIVMRQSA DELPRRFLL VFRLCLDQT 
L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8X16ANucleotideAdenosineA3AHomo sapiensPiclidenoson-Gi1/β1/γ23.292024-04-24doi.org/10.1038/s41467-024-47207-6
8X16 (No Gprot) ANucleotideAdenosineA3AHomo sapiensPiclidenoson-3.292024-04-24doi.org/10.1038/s41467-024-47207-6
8X17ANucleotideAdenosineA3AHomo sapiensNamodenoson-Gi1/β1/γ23.192024-04-24doi.org/10.1038/s41467-024-47207-6
8X17 (No Gprot) ANucleotideAdenosineA3AHomo sapiensNamodenoson-3.192024-04-24doi.org/10.1038/s41467-024-47207-6
8YH0ANucleotideAdenosineA3AHomo sapiensNECA-Gi1/β1/γ22.862024-11-06doi.org/10.1038/s41467-024-53473-1
8YH0 (No Gprot) ANucleotideAdenosineA3AHomo sapiensNECA-2.862024-11-06doi.org/10.1038/s41467-024-53473-1
8YH2ANucleotideAdenosineA3AHomo sapiensAdenosine-Gi1/β1/γ23.272024-11-06doi.org/10.1038/s41467-024-53473-1
8YH2 (No Gprot) ANucleotideAdenosineA3AHomo sapiensAdenosine-3.272024-11-06doi.org/10.1038/s41467-024-53473-1
8YH3ANucleotideAdenosineA3AHomo sapiensN-methyladenosine-Gi1/β1/γ23.42024-11-06doi.org/10.1038/s41467-024-53473-1
8YH3 (No Gprot) ANucleotideAdenosineA3AHomo sapiensN-methyladenosine-3.42024-11-06doi.org/10.1038/s41467-024-53473-1
8YH5ANucleotideAdenosineA3AHomo sapiensRiboprine-Gi1/β1/γ23.662024-11-06doi.org/10.1038/s41467-024-53473-1
8YH5 (No Gprot) ANucleotideAdenosineA3AHomo sapiensRiboprine-3.662024-11-06doi.org/10.1038/s41467-024-53473-1
8YH6ANucleotideAdenosineA3AHomo sapiensNamodenoson-Gi1/β1/γ23.622024-11-06doi.org/10.1038/s41467-024-53473-1
8YH6 (No Gprot) ANucleotideAdenosineA3AHomo sapiensNamodenoson-3.622024-11-06doi.org/10.1038/s41467-024-53473-1
9EHSANucleotideAdenosineA3AHomo sapiensLUF7602--3.22025-08-20doi.org/10.1038/s41467-025-62872-x
9EBIANucleotideAdenosineA3AHomo sapiensPiclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ23.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBI (No Gprot) ANucleotideAdenosineA3AHomo sapiensPiclidenoson-3.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBHANucleotideAdenosineA3AHomo sapiensAdenosine-Gi1/β1/γ23.62025-08-20doi.org/10.1038/s41467-025-62872-x
9EBH (No Gprot) ANucleotideAdenosineA3AHomo sapiensAdenosine-3.62025-08-20doi.org/10.1038/s41467-025-62872-x




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Download 8YH0_nogp.zip



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