psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S9	R:R:T11	4.8	No	No	0	4	4
2	R:R:S12	R:R:S9	3.26	No	No	0	3	4
3	R:R:T11	R:R:Y265	3.75	No	Yes	0	4	4
4	R:R:S12	R:R:Y265	3.82	No	Yes	0	3	4
5	R:R:E19	R:R:Y15	7.86	Yes	Yes	1	5	4
6	R:R:S73	R:R:Y15	5.09	No	Yes	0	5	4
7	R:R:Y15	R:R:Y265	29.79	Yes	Yes	0	4	4
8	R:R:I268	R:R:Y15	12.09	Yes	Yes	1	5	4
9	R:R:L269	R:R:Y15	5.86	No	Yes	1	5	4
10	R:R:I16	R:R:I70	5.89	No	No	0	5	6
11	R:R:L269	R:R:V18	11.92	No	No	0	5	4
12	R:R:E19	R:R:I268	4.1	Yes	Yes	1	5	5
13	R:R:E19	R:R:L269	5.3	Yes	No	1	5	5
14	R:R:E19	R:R:H272	16	Yes	Yes	1	5	7
15	R:R:I22	R:R:M276	11.66	No	No	0	7	6
16	R:R:C25	R:R:M276	4.86	No	No	0	5	6
17	R:R:A26	R:R:S275	3.42	No	No	0	7	9
18	R:R:G62	R:R:I27	3.53	No	No	0	6	6
19	R:R:G29	R:R:V28	3.68	No	No	0	8	4
20	R:R:D58	R:R:N30	10.77	Yes	Yes	0	9	9
21	R:R:I59	R:R:N30	5.66	No	Yes	0	7	9
22	R:R:N30	R:R:P279	6.52	Yes	No	0	9	9
23	R:R:A283	R:R:V33	3.39	No	No	4	7	9
24	R:R:F289	R:R:V33	7.87	No	No	4	8	9
25	R:R:L39	R:R:W35	18.22	No	No	2	5	4
26	R:R:I296	R:R:W35	3.52	No	No	2	5	4
27	R:R:F289	R:R:V36	11.8	No	No	0	8	8
28	R:R:T292	R:R:V36	4.76	Yes	No	0	7	8
29	R:R:V37	R:R:V52	4.81	No	No	5	8	5
30	R:R:I296	R:R:L39	4.28	No	No	2	5	5
31	R:R:L43	R:R:N40	4.12	Yes	No	2	8	5
32	R:R:N40	R:R:T292	16.08	No	Yes	2	5	7
33	R:R:F48	R:R:L43	14.61	No	Yes	0	9	8
34	R:R:L43	R:R:T292	4.42	Yes	Yes	2	8	7
35	R:R:R111	R:R:T46	5.17	Yes	No	3	8	5
36	R:R:T46	R:R:Y118	6.24	No	Yes	3	5	8
37	R:R:I127	R:R:T46	4.56	No	No	0	6	5
38	R:R:F48	R:R:T47	6.49	No	No	0	9	8
39	R:R:R111	R:R:T47	9.06	Yes	No	0	8	8
40	R:R:Q124	R:R:Y49	10.15	No	No	6	3	4
41	R:R:I127	R:R:Y49	6.04	No	No	0	6	4
42	R:R:W128	R:R:Y49	9.65	No	No	6	1	4
43	R:R:D107	R:R:F50	13.14	No	No	0	9	8
44	R:R:F50	R:R:L131	3.65	No	No	0	8	7
45	R:R:S100	R:R:S53	3.26	No	No	0	7	9
46	R:R:L131	R:R:S53	6.01	No	No	0	7	9
47	R:R:D58	R:R:L54	8.14	Yes	Yes	1	9	9
48	R:R:L54	R:R:S100	6.01	Yes	No	0	9	7
49	R:R:L101	R:R:L54	4.15	No	Yes	1	8	9
50	R:R:I104	R:R:L54	4.28	No	Yes	1	8	9
51	R:R:L54	R:R:N278	6.87	Yes	Yes	1	9	9
52	R:R:D58	R:R:S275	4.42	Yes	No	0	9	9
53	R:R:D58	R:R:N278	8.08	Yes	Yes	1	9	9
54	R:R:A60	R:R:F93	8.32	No	Yes	0	6	6
55	R:R:S275	R:R:V61	6.46	No	No	0	9	8
56	R:R:F93	R:R:L64	7.31	Yes	No	0	6	4
57	R:R:M90	R:R:V65	9.13	No	No	0	6	7
58	R:R:F93	R:R:V65	3.93	Yes	No	0	6	7
59	R:R:H272	R:R:V65	4.15	Yes	No	0	7	7
60	R:R:M66	R:R:P67	11.74	Yes	No	0	6	8
61	R:R:L68	R:R:M86	7.07	No	No	0	5	6
62	R:R:L68	R:R:L89	4.15	No	No	0	5	5
63	R:R:L68	R:R:M90	4.24	No	No	0	5	6
64	R:R:C166	R:R:I72	3.27	No	No	0	9	5
65	R:R:P165	R:R:T77	3.5	No	No	0	5	3
66	R:R:C166	R:R:I78	6.55	No	No	0	9	5
67	R:R:H79	R:R:Y81	3.27	No	No	0	7	1
68	R:R:H79	R:R:T162	4.11	No	No	7	7	3
69	R:R:F163	R:R:H79	9.05	No	No	7	2	7
70	R:R:F80	R:R:Y81	7.22	Yes	No	0	3	1
71	R:R:F80	R:R:N150	7.25	Yes	Yes	8	3	5
72	R:R:F80	R:R:K152	4.96	Yes	No	8	3	4
73	R:R:F80	R:R:L164	3.65	Yes	No	0	3	4
74	R:R:F80	R:R:V171	7.87	Yes	No	0	3	5
75	R:R:C166	R:R:C83	7.28	No	No	0	9	9
76	R:R:C83	R:R:V171	5.12	No	No	0	9	5
77	R:R:L84	R:R:T87	4.42	No	Yes	0	6	4
78	R:R:L84	R:R:N150	4.12	No	Yes	0	6	5
79	R:R:F85	R:R:L89	10.96	No	No	0	5	5
80	R:R:F85	R:R:M146	4.98	No	Yes	0	5	5
81	R:R:F168	R:R:T87	5.19	Yes	Yes	1	5	4
82	R:R:T87	R:R:V171	4.76	Yes	No	0	4	5
83	R:R:M172	R:R:T87	4.52	Yes	Yes	1	4	4
84	R:R:C88	R:R:P145	5.65	No	Yes	0	6	5
85	R:R:C88	R:R:M146	4.86	No	Yes	0	6	5
86	R:R:F93	R:R:L89	3.65	Yes	No	0	6	5
87	R:R:H95	R:R:L91	3.86	Yes	Yes	1	6	4
88	R:R:L91	R:R:M172	4.24	Yes	Yes	1	4	4
89	R:R:L91	R:R:Y176	3.52	Yes	Yes	1	4	6
90	R:R:L91	R:R:M177	5.65	Yes	Yes	1	4	5
91	L:L:?1	R:R:L91	4.8	Yes	Yes	1	0	4
92	R:R:F93	R:R:I92	11.3	Yes	No	0	6	5
93	R:R:F139	R:R:I92	3.77	No	No	0	4	5
94	R:R:G142	R:R:I92	3.53	No	No	0	7	5
95	R:R:T94	R:R:W243	3.64	No	Yes	1	6	8
96	L:L:?1	R:R:T94	11.25	Yes	No	1	0	6
97	R:R:H95	R:R:V141	6.92	Yes	No	0	6	4
98	R:R:H95	R:R:S181	8.37	Yes	No	0	6	5
99	L:L:?1	R:R:H95	8.03	Yes	Yes	1	0	6
100	R:R:A96	R:R:W135	7.78	No	No	0	7	9
101	R:R:A96	R:R:S138	3.42	No	No	0	7	8
102	R:R:I98	R:R:P189	3.39	No	No	0	8	8
103	R:R:F239	R:R:I98	7.54	Yes	No	1	8	8
104	R:R:I98	R:R:W243	10.57	No	Yes	1	8	8
105	R:R:L101	R:R:N278	12.36	No	Yes	1	8	9
106	R:R:L101	R:R:Y282	4.69	No	Yes	1	8	9
107	R:R:L102	R:R:P189	4.93	Yes	No	0	7	8
108	R:R:L102	R:R:V192	4.47	Yes	No	0	7	6
109	R:R:I104	R:R:R108	3.76	No	No	1	8	9
110	R:R:I104	R:R:Y282	7.25	No	Yes	1	8	9
111	R:R:A105	R:R:Y197	4	No	Yes	0	8	9
112	R:R:D107	R:R:R111	11.91	No	Yes	3	9	8
113	R:R:D107	R:R:Y118	5.75	No	Yes	3	9	8
114	R:R:R108	R:R:Y197	6.17	No	Yes	1	9	9
115	R:R:R108	R:R:Y282	6.17	No	Yes	1	9	9
116	R:R:K113	R:R:Y109	9.55	No	No	0	6	8
117	R:R:I196	R:R:Y109	4.84	No	No	0	6	8
118	R:R:D199	R:R:Y109	6.9	No	No	0	4	8
119	R:R:L110	R:R:L114	4.15	No	Yes	0	5	5
120	R:R:R111	R:R:Y118	21.61	Yes	Yes	3	8	8
121	R:R:I200	R:R:V112	9.22	No	No	0	9	9
122	R:R:I203	R:R:V112	6.14	No	No	0	5	9
123	R:R:L114	R:R:Y118	3.52	Yes	Yes	0	5	8
124	R:R:L114	R:R:V121	4.47	Yes	No	0	5	4
125	R:R:T115	R:R:V116	4.76	No	No	0	8	6
126	R:R:T122	R:R:Y118	14.98	No	Yes	0	6	8
127	R:R:R126	R:R:T123	6.47	No	No	0	5	8
128	R:R:Q124	R:R:W128	3.29	No	No	6	3	1
129	R:R:V137	R:R:W185	4.9	No	No	0	4	5
130	R:R:V141	R:R:W185	17.16	No	No	0	4	5
131	R:R:P145	R:R:T144	3.5	Yes	No	0	5	5
132	R:R:M172	R:R:P145	5.03	Yes	Yes	1	4	5
133	R:R:P145	R:R:Y176	12.52	Yes	Yes	1	5	6
134	R:R:K152	R:R:N150	4.2	No	Yes	8	4	5
135	R:R:M151	R:R:R173	3.72	No	No	0	4	4
136	R:R:R173	R:R:S154	5.27	No	No	0	4	2
137	R:R:F163	R:R:T162	6.49	No	No	7	2	3
138	R:R:L164	R:R:P165	3.28	No	No	0	4	5
139	R:R:R167	R:R:S170	5.27	No	No	0	5	4
140	R:R:F168	R:R:M172	8.71	Yes	Yes	1	5	4
141	R:R:F168	R:R:M177	8.71	Yes	Yes	1	5	5
142	L:L:?1	R:R:F168	36.35	Yes	Yes	1	0	5
143	R:R:M174	R:R:R169	8.69	No	No	0	3	4
144	R:R:M172	R:R:Y176	7.18	Yes	Yes	1	4	6
145	R:R:D175	R:R:R173	17.87	No	No	0	4	4
146	R:R:M174	R:R:N250	4.21	No	No	0	3	5
147	R:R:M174	R:R:Y254	3.59	No	Yes	0	3	4
148	R:R:D175	R:R:Y254	4.6	No	Yes	0	4	4
149	R:R:M177	R:R:Y176	5.99	Yes	Yes	1	5	6
150	R:R:F180	R:R:Y176	9.28	No	Yes	0	5	6
151	L:L:?1	R:R:M177	5.89	Yes	Yes	1	0	5
152	R:R:V178	R:R:Y179	3.79	No	No	9	5	3
153	R:R:C251	R:R:V178	3.42	No	No	0	5	5
154	R:R:V178	R:R:Y254	5.05	No	Yes	9	5	4
155	R:R:Y179	R:R:Y254	10.92	No	Yes	9	3	4
156	R:R:F182	R:R:I186	7.54	No	No	0	5	7
157	R:R:F182	R:R:L187	6.09	No	No	0	5	4
158	R:R:F182	R:R:S247	17.18	No	No	0	5	6
159	R:R:L184	R:R:W185	10.25	No	No	0	3	5
160	R:R:P189	R:R:V188	3.53	No	No	0	8	4
161	R:R:F239	R:R:L190	9.74	Yes	No	0	8	6
162	R:R:A240	R:R:L190	4.73	No	No	0	6	6
163	R:R:C194	R:R:L236	6.35	No	No	0	4	7
164	R:R:L232	R:R:Y197	15.24	No	Yes	0	8	9
165	R:R:V235	R:R:Y197	6.31	No	Yes	1	8	9
166	R:R:L236	R:R:Y197	4.69	No	Yes	0	7	9
167	R:R:Y197	R:R:Y282	3.97	Yes	Yes	1	9	9
168	R:R:D199	R:R:I203	4.2	No	No	0	4	5
169	R:R:E225	R:R:F201	3.5	Yes	No	0	7	5
170	R:R:A229	R:R:F201	5.55	No	No	0	7	5
171	R:R:I204	R:R:T228	4.56	No	No	0	8	7
172	R:R:E225	R:R:R205	5.82	Yes	No	0	7	5
173	R:R:E225	R:R:F226	4.66	Yes	No	0	7	4
174	R:R:K285	R:R:S231	6.12	No	No	0	7	8
175	R:R:L234	R:R:L238	5.54	No	No	1	6	6
176	R:R:L234	R:R:V281	8.94	No	No	1	6	8
177	R:R:V235	R:R:Y282	12.62	No	Yes	1	8	9
178	R:R:F237	R:R:L241	9.74	No	No	0	4	5
179	R:R:L238	R:R:V281	4.47	No	No	1	6	8
180	R:R:F239	R:R:W243	11.02	Yes	Yes	1	8	8
181	R:R:F239	R:R:N274	3.62	Yes	Yes	1	8	9
182	R:R:C242	R:R:N274	6.3	No	Yes	0	8	9
183	R:R:S271	R:R:W243	11.12	No	Yes	0	7	8
184	R:R:N274	R:R:W243	5.65	Yes	Yes	1	9	8
185	L:L:?1	R:R:W243	6.32	Yes	Yes	1	0	8
186	R:R:L270	R:R:P245	3.28	No	No	0	7	9
187	R:R:G267	R:R:L246	3.42	No	No	0	6	6
188	L:L:?1	R:R:L246	10.57	Yes	No	0	0	6
189	R:R:I249	R:R:V263	4.61	No	No	0	5	4
190	L:L:?1	R:R:N250	8.58	Yes	No	0	0	5
191	R:R:L253	R:R:V259	5.96	No	Yes	0	4	4
192	R:R:F255	R:R:Y254	11.35	No	Yes	0	4	4
193	R:R:G257	R:R:Q258	4.93	No	No	0	1	2
194	R:R:P260	R:R:V259	3.53	No	Yes	10	4	4
195	R:R:V259	R:R:V263	4.81	Yes	No	10	4	4
196	R:R:P260	R:R:V263	5.3	No	No	10	4	4
197	R:R:L264	R:R:Q261	7.99	No	No	0	4	2
198	R:R:Q261	R:R:Y265	19.16	No	Yes	0	2	4
199	L:L:?1	R:R:L264	6.72	Yes	No	0	0	4
200	R:R:H272	R:R:I268	6.63	Yes	Yes	1	7	5
201	L:L:?1	R:R:I268	7.92	Yes	Yes	1	0	5
202	L:L:?1	R:R:H272	7.14	Yes	Yes	1	0	7
203	R:R:N274	R:R:N278	9.54	Yes	Yes	1	9	9
204	R:R:A283	R:R:F289	8.32	No	No	4	7	8
205	R:R:K290	R:R:Y284	16.72	No	No	0	8	5
206	R:R:I286	R:R:K288	4.36	No	No	0	8	6
207	R:R:E291	R:R:K287	9.45	No	No	0	5	5
208	R:R:A273	R:R:I22	3.25	No	No	0	6	7
209	R:R:A55	R:R:I34	3.25	No	No	0	9	7
210	R:R:S97	R:R:V61	3.23	No	No	0	9	8
211	R:R:A105	R:R:M193	3.22	No	No	0	8	8
212	R:R:V235	R:R:V281	3.21	No	No	1	8	8
213	R:R:T11	R:R:T262	3.14	No	No	0	4	2
214	R:R:A55	R:R:N30	3.13	No	Yes	0	9	9
215	R:R:R119	R:R:Y118	3.09	No	Yes	0	4	8
216	R:R:I22	R:R:V18	3.07	No	No	0	7	4
217	R:R:I27	R:R:V63	3.07	No	No	0	6	4
218	R:R:I34	R:R:V52	3.07	No	No	0	7	5
219	R:R:I78	R:R:V76	3.07	No	No	0	5	2
220	R:R:M99	R:R:S138	3.07	No	No	0	5	8
221	R:R:I196	R:R:V192	3.07	No	No	0	6	6
222	R:R:I252	R:R:V259	3.07	No	Yes	0	4	4
223	R:R:K38	R:R:V37	3.04	No	No	5	1	8
224	R:R:K38	R:R:V52	3.04	No	No	5	1	5
225	R:R:M86	R:R:V71	3.04	No	No	0	6	4
226	R:R:I296	R:R:T292	3.04	No	Yes	2	5	7
227	R:R:A69	R:R:E19	3.02	No	Yes	0	6	5
228	R:R:L74	R:R:S73	3	No	No	0	4	5
229	R:R:L32	R:R:V28	2.98	No	No	0	6	4
230	R:R:L64	R:R:V63	2.98	No	No	0	4	4
231	R:R:L102	R:R:V106	2.98	Yes	No	0	7	6
232	R:R:L133	R:R:V137	2.98	No	No	0	3	4
233	L:L:?1	R:R:I186	2.97	Yes	No	0	0	7
234	R:R:L21	R:R:T17	2.95	No	No	0	4	6
235	R:R:L232	R:R:T228	2.95	No	No	0	8	7
236	R:R:I20	R:R:M66	2.92	No	Yes	0	4	6
237	R:R:I34	R:R:L56	2.85	No	No	0	7	6
238	R:R:I249	R:R:L246	2.85	No	No	0	5	6
239	R:R:L24	R:R:M66	2.83	No	Yes	0	4	6
240	R:R:L102	R:R:M99	2.83	Yes	No	0	7	5
241	R:R:L143	R:R:M146	2.83	No	Yes	0	4	5
242	R:R:L238	R:R:M277	2.83	No	No	0	6	6
243	R:R:K288	R:R:L43	2.82	No	Yes	0	6	8
244	R:R:A103	R:R:F50	2.77	No	No	0	6	8
245	R:R:L161	R:R:L164	2.77	No	No	0	3	4
246	R:R:L190	R:R:L244	2.77	No	No	0	6	6
247	R:R:F48	R:R:T45	2.59	No	No	0	9	7
248	R:R:A57	R:R:W135	2.59	No	No	0	8	9
249	R:R:V36	R:R:Y293	2.52	No	Yes	0	8	7
250	R:R:F147	R:R:M146	2.49	No	Yes	0	5	5
251	R:R:F183	R:R:L184	2.44	No	No	0	4	3
252	R:R:L114	R:R:R117	2.43	Yes	No	0	5	5
253	R:R:T144	R:R:W149	2.43	No	No	0	5	6
254	R:R:I203	R:R:Y202	2.42	No	No	0	5	3
255	R:R:N206	R:R:Y202	2.33	No	No	0	4	3
256	R:R:G23	R:R:G62	2.11	No	No	0	6	6
257	R:R:A103	R:R:C134	1.81	No	No	0	6	7
258	R:R:G257	R:R:I252	1.76	No	No	0	1	4
259	R:R:G23	R:R:M66	1.75	No	Yes	0	6	6
260	R:R:G132	R:R:L131	1.71	No	No	0	4	7
261	R:R:G267	R:R:L266	1.71	No	No	0	6	4
262	R:R:G267	R:R:L270	1.71	No	No	0	6	7
263	R:R:I280	R:R:P279	1.69	No	No	0	6	9
264	R:R:N40	R:R:P41	1.63	No	No	0	5	6
265	R:R:A283	R:R:I51	1.62	No	No	0	7	8
266	R:R:T17	R:R:V13	1.59	No	No	0	6	3
267	R:R:T14	R:R:V18	1.59	No	No	0	4	4
268	R:R:I27	R:R:V31	1.54	No	No	0	6	4
269	R:R:L187	R:R:V191	1.49	No	No	0	4	4
270	R:R:L140	R:R:T144	1.47	No	No	0	4	5
271	R:R:I248	R:R:I252	1.47	No	No	0	5	4
272	R:R:I70	R:R:M66	1.46	No	Yes	0	6	6
273	R:R:I20	R:R:L21	1.43	No	No	0	4	4
274	R:R:I204	R:R:L208	1.43	No	No	0	8	4
275	R:R:K285	R:R:L234	1.41	No	No	0	7	6
276	R:R:L153	R:R:N150	1.37	No	Yes	0	3	5
277	R:R:E159	R:R:K152	1.35	No	No	0	2	4
278	R:R:E225	R:R:L208	1.33	Yes	No	0	7	4
279	R:R:R117	R:R:V116	1.31	No	No	0	5	6
280	R:R:E159	R:R:N160	1.31	No	No	0	2	4
281	R:R:L32	R:R:Y293	1.17	No	Yes	0	6	7
282	R:R:L294	R:R:Y293	1.17	No	Yes	0	4	7
283	R:R:Y284	R:R:Y293	0.99	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y15	12.138	5	1	4
2	R:R:E19	7.256	5	1	5
3	R:R:N30	6.52	4	0	9
4	R:R:L43	6.4925	4	2	8
5	R:R:L54	5.89	5	1	9
6	R:R:D58	7.8525	4	1	9
7	R:R:M66	4.14	5	0	6
8	R:R:F80	6.19	5	8	3
9	R:R:T87	4.7225	4	1	4
10	R:R:L91	4.414	5	1	4
11	R:R:F93	6.902	5	0	6
12	R:R:H95	6.795	4	1	6
13	R:R:L102	3.8025	4	0	7
14	R:R:R111	11.9375	4	3	8
15	R:R:L114	3.6425	4	0	5
16	R:R:Y118	9.19833	6	3	8
17	R:R:P145	6.675	4	1	5
18	R:R:M146	3.79	4	0	5
19	R:R:N150	4.235	4	8	5
20	R:R:F168	14.74	4	1	5
21	R:R:M172	5.936	5	1	4
22	R:R:Y176	7.698	5	1	6
23	R:R:M177	6.56	4	1	5
24	R:R:Y197	6.73	6	1	9
25	R:R:E225	3.8275	4	0	7
26	R:R:F239	7.98	4	1	8
27	R:R:W243	8.05333	6	1	8
28	R:R:Y254	7.102	5	9	4
29	R:R:V259	4.3425	4	10	4
30	R:R:Y265	14.13	4	0	4
31	R:R:I268	7.685	4	1	5
32	R:R:H272	8.48	4	1	7
33	R:R:N274	6.2775	4	1	9
34	R:R:N278	9.2125	4	1	9
35	R:R:Y282	6.94	5	1	9
36	R:R:T292	7.075	4	2	7
37	R:R:Y293	1.4625	4	0	7
38	L:L:?1	9.71167	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I268	R:R:Y15	17.9456	12.09	Yes	Yes	1	5	4
2	R:R:G23	R:R:M66	10.7796	1.75	No	Yes	0	6	6
3	R:R:G23	R:R:G62	11.9308	2.11	No	No	0	6	6
4	R:R:G62	R:R:I27	13.0727	3.53	No	No	0	6	6
5	R:R:I27	R:R:V63	15.3282	3.07	No	No	0	6	4
6	R:R:L64	R:R:V63	16.4419	2.98	No	No	0	4	4
7	R:R:F93	R:R:L64	17.5462	7.31	Yes	No	0	6	4
8	R:R:F93	R:R:V65	24.106	3.93	Yes	No	0	6	7
9	R:R:H272	R:R:V65	29.4206	4.15	Yes	No	0	7	7
10	R:R:E19	R:R:H272	11.8791	16	Yes	Yes	1	5	7
11	R:R:L269	R:R:V18	19.844	11.92	No	No	0	5	4
12	R:R:I22	R:R:V18	13.2654	3.07	No	No	0	7	4
13	R:R:D58	R:R:N278	17.4569	8.08	Yes	Yes	1	9	9
14	R:R:N274	R:R:N278	98.8018	9.54	Yes	Yes	1	9	9
15	R:R:N274	R:R:W243	89.1358	5.65	Yes	Yes	1	9	8
16	L:L:?1	R:R:W243	100	6.32	Yes	Yes	1	0	8
17	L:L:?1	R:R:I268	26.916	7.92	Yes	Yes	1	0	5
18	R:R:V36	R:R:Y293	11.1367	2.52	No	Yes	0	8	7
19	R:R:T292	R:R:V36	18.7679	4.76	Yes	No	0	7	8
20	R:R:L43	R:R:T292	24.2329	4.42	Yes	Yes	2	8	7
21	R:R:F48	R:R:L43	31.5587	14.61	No	Yes	0	9	8
22	R:R:F48	R:R:T47	34.4439	6.49	No	No	0	9	8
23	R:R:R111	R:R:T47	35.8583	9.06	Yes	No	0	8	8
24	R:R:D107	R:R:R111	43.0337	11.91	No	Yes	3	9	8
25	R:R:D107	R:R:F50	64.1699	13.14	No	No	0	9	8
26	R:R:F50	R:R:L131	67.8962	3.65	No	No	0	8	7
27	R:R:L131	R:R:S53	70.3679	6.01	No	No	0	7	9
28	R:R:S100	R:R:S53	71.5709	3.26	No	No	0	7	9
29	R:R:L54	R:R:S100	72.7597	6.01	Yes	No	0	9	7
30	R:R:L54	R:R:N278	57.5255	6.87	Yes	Yes	1	9	9
31	R:R:D58	R:R:N30	17.0669	10.77	Yes	Yes	0	9	9
32	R:R:A55	R:R:N30	10.2439	3.13	No	Yes	0	9	9
33	R:R:D107	R:R:Y118	20.0742	5.75	No	Yes	3	9	8
34	R:R:I127	R:R:T46	12.3255	4.56	No	No	0	6	5
35	R:R:L101	R:R:N278	26.385	12.36	No	Yes	1	8	9
36	R:R:I104	R:R:L54	13.7682	4.28	No	Yes	1	8	9
37	R:R:T87	R:R:V171	21.2678	4.76	Yes	No	0	4	5
38	R:R:F168	R:R:T87	26.6529	5.19	Yes	Yes	1	5	4
39	L:L:?1	R:R:F168	35.4213	36.35	Yes	Yes	1	0	5
40	R:R:F80	R:R:V171	14.6375	7.87	Yes	No	0	3	5
41	R:R:C88	R:R:M146	11.5596	4.86	No	Yes	0	6	5
42	R:R:C88	R:R:P145	15.4222	5.65	No	Yes	0	6	5
43	R:R:M172	R:R:P145	15.737	5.03	Yes	Yes	1	4	5
44	L:L:?1	R:R:L91	18.002	4.8	Yes	Yes	1	0	4
45	R:R:P145	R:R:Y176	14.6469	12.52	Yes	Yes	1	5	6
46	L:L:?1	R:R:M177	10.1264	5.89	Yes	Yes	1	0	5
47	R:R:L102	R:R:P189	30.0644	4.93	Yes	No	0	7	8
48	R:R:I98	R:R:P189	33.4665	3.39	No	No	0	8	8
49	R:R:I98	R:R:W243	25.7225	10.57	No	Yes	1	8	8
50	R:R:L101	R:R:Y282	32.146	4.69	No	Yes	1	8	9
51	R:R:L102	R:R:V192	18.0443	4.47	Yes	No	0	7	6
52	R:R:Y197	R:R:Y282	24.1765	3.97	Yes	Yes	1	9	9
53	R:R:I196	R:R:Y109	14.4683	4.84	No	No	0	6	8
54	R:R:I196	R:R:V192	16.2633	3.07	No	No	0	6	6
55	R:R:D199	R:R:Y109	11.038	6.9	No	No	0	4	8
56	R:R:P145	R:R:T144	12.4994	3.5	Yes	No	0	5	5
57	R:R:M174	R:R:Y254	12.1564	3.59	No	Yes	0	3	4
58	R:R:M174	R:R:N250	14.6422	4.21	No	No	0	3	5
59	L:L:?1	R:R:N250	15.7464	8.58	Yes	No	0	0	5
60	R:R:L232	R:R:Y197	18.9982	15.24	No	Yes	0	8	9
61	R:R:V235	R:R:Y282	12.3396	12.62	No	Yes	1	8	9
62	R:R:E225	R:R:L208	10.9534	1.33	Yes	No	0	7	4
63	R:R:I204	R:R:L208	13.1291	1.43	No	No	0	8	4
64	R:R:I204	R:R:T228	14.9946	4.56	No	No	0	8	7
65	R:R:L232	R:R:T228	17.1468	2.95	No	No	0	8	7
66	R:R:V235	R:R:V281	11.1837	3.21	No	No	1	8	8
67	L:L:?1	R:R:L246	18.6786	10.57	Yes	No	0	0	6
68	R:R:I249	R:R:L246	12.147	2.85	No	No	0	5	6
69	R:R:I249	R:R:V263	10.8125	4.61	No	No	0	5	4
70	R:R:E19	R:R:L269	15.5209	5.3	Yes	No	1	5	5
71	L:L:?1	R:R:H272	35.5246	7.14	Yes	Yes	1	0	7
72	R:R:F239	R:R:N274	10.8735	3.62	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E19	R:R:Y15	7.86	1	Yes	Yes	5	4	2	2
R:R:I268	R:R:Y15	12.09	1	Yes	Yes	5	4	1	2
R:R:E19	R:R:I268	4.1	1	Yes	Yes	5	5	2	1
R:R:E19	R:R:H272	16	1	Yes	Yes	5	7	2	1
R:R:H272	R:R:V65	4.15	1	Yes	No	7	7	1	2
R:R:F168	R:R:T87	5.19	1	Yes	Yes	5	4	1	2
R:R:M172	R:R:T87	4.52	1	Yes	Yes	4	4	2	2
R:R:H95	R:R:L91	3.86	1	Yes	Yes	6	4	1	1
R:R:L91	R:R:M172	4.24	1	Yes	Yes	4	4	1	2
R:R:L91	R:R:Y176	3.52	1	Yes	Yes	4	6	1	2
R:R:L91	R:R:M177	5.65	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:L91	4.8	1	Yes	Yes	0	4	0	1
R:R:T94	R:R:W243	3.64	1	No	Yes	6	8	1	1
L:L:?1	R:R:T94	11.25	1	Yes	No	0	6	0	1
R:R:H95	R:R:V141	6.92	1	Yes	No	6	4	1	2
R:R:H95	R:R:S181	8.37	1	Yes	No	6	5	1	2
L:L:?1	R:R:H95	8.03	1	Yes	Yes	0	6	0	1
R:R:F239	R:R:I98	7.54	1	Yes	No	8	8	2	2
R:R:I98	R:R:W243	10.57	1	No	Yes	8	8	2	1
R:R:F168	R:R:M172	8.71	1	Yes	Yes	5	4	1	2
R:R:F168	R:R:M177	8.71	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:F168	36.35	1	Yes	Yes	0	5	0	1
R:R:M172	R:R:Y176	7.18	1	Yes	Yes	4	6	2	2
R:R:M174	R:R:N250	4.21	0	No	No	3	5	2	1
R:R:M177	R:R:Y176	5.99	1	Yes	Yes	5	6	1	2
L:L:?1	R:R:M177	5.89	1	Yes	Yes	0	5	0	1
R:R:F182	R:R:I186	7.54	0	No	No	5	7	2	1
R:R:F239	R:R:W243	11.02	1	Yes	Yes	8	8	2	1
R:R:F239	R:R:N274	3.62	1	Yes	Yes	8	9	2	2
R:R:S271	R:R:W243	11.12	0	No	Yes	7	8	2	1
R:R:N274	R:R:W243	5.65	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:W243	6.32	1	Yes	Yes	0	8	0	1
R:R:G267	R:R:L246	3.42	0	No	No	6	6	2	1
L:L:?1	R:R:L246	10.57	1	Yes	No	0	6	0	1
L:L:?1	R:R:N250	8.58	1	Yes	No	0	5	0	1
R:R:L264	R:R:Q261	7.99	0	No	No	4	2	1	2
L:L:?1	R:R:L264	6.72	1	Yes	No	0	4	0	1
R:R:H272	R:R:I268	6.63	1	Yes	Yes	7	5	1	1
L:L:?1	R:R:I268	7.92	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:H272	7.14	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I186	2.97	1	Yes	No	0	7	0	1
R:R:I249	R:R:L246	2.85	0	No	No	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YH0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.26
Number of Linked Nodes	250
Number of Links	283
Number of Hubs	38
Number of Links mediated by Hubs	139
Number of Communities	10
Number of Nodes involved in Communities	62
Number of Links involved in Communities	85

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	45068
Length Of Smallest Path	3
Average Path Length	13.1041
Length of Longest Path	33
Minimum Path Strength	1.08
Average Path Strength	6.91769
Maximum Path Strength	24.475
Minimum Path Correlation	0.7
Average Path Correlation	0.921756
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	46.9465
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.8916
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NEC
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NEC
Name	N-Ethyl-5'-Carboxamido Adenosine
Synonyms	N-Ethyl-5'-Carboxamido Adenosine
Identifier
Formula	C12 H16 N6 O4
Molecular Weight	308.293
SMILES
PubChem	448222
Formal Charge	0
Total Atoms	38
Total Chiral Atoms	4
Total Bonds	40
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P0DMS8
Sequence	>8YH0_nogp_Chain_R S V T Y I T E I I G L C A I V G N V L V I V V K L N P S L Q T T T F Y F I V S L A L A D I A V G V L V M P L A I V S L G T I H F Y S C L F M T C L L I F T H A S I M S L L A I A V D R Y L R V K L T V R Y R V T T R R I W L A L G L C W L V S F L V G L T P M F G W N M K L S N T F L C F S V M R M D Y M V Y F S F W I P L V V M C A I Y D I F Y I I R N L E F K T A K S L L V L F L F A L W L P L S I I N C I Y F G V P Q V L Y G I L L S H A N S M M N P I V Y A Y K I K K F K E T Y L L I W T S V L W I V M R Q S A D E L P R R F L L V F R L C L D Q T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8X16	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	Gi1/β1/γ2	3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X16 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8YH0	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-	Gi1/β1/γ2	2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH0 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-		2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-	Gi1/β1/γ2	3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-		3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	9EBH	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBH (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	chim(NtGi1L-Gs-CtGi1)/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EHS	A	Nucleotide	Adenosine	A_3A	Homo sapiens	LUF7602	-	-	3.2	2025-08-20	doi.org/10.1038/s41467-025-62872-x

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