psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L91	6.75	Yes	No	0	0	4
2	L:L:?1	R:R:T94	11.68	Yes	No	1	0	6
3	L:L:?1	R:R:H95	4.7	Yes	Yes	0	0	6
4	L:L:?1	R:R:F168	34.9	Yes	Yes	1	0	5
5	L:L:?1	R:R:V169	6.36	Yes	No	0	0	4
6	L:L:?1	R:R:M174	6.9	Yes	No	0	0	3
7	L:L:?1	R:R:W243	8.33	Yes	Yes	1	0	8
8	L:L:?1	R:R:L246	11.81	Yes	No	0	0	6
9	L:L:?1	R:R:N250	9.21	Yes	No	0	0	5
10	L:L:?1	R:R:I268	6.96	Yes	No	1	0	5
11	L:L:?1	R:R:S271	5.49	Yes	No	1	0	7
12	L:L:?1	R:R:H272	10.19	Yes	Yes	1	0	7
13	R:R:A11	R:R:L262	4.73	No	No	0	4	2
14	R:R:N12	R:R:Y265	9.3	No	Yes	0	3	4
15	R:R:E19	R:R:Y15	15.71	Yes	Yes	1	5	4
16	R:R:S73	R:R:Y15	5.09	No	Yes	1	5	4
17	R:R:Y15	R:R:Y265	18.86	Yes	Yes	0	4	4
18	R:R:I268	R:R:Y15	7.25	No	Yes	1	5	4
19	R:R:L269	R:R:Y15	5.86	No	Yes	1	5	4
20	R:R:I16	R:R:I70	10.3	No	No	1	5	6
21	R:R:L269	R:R:M18	7.07	No	No	0	5	4
22	R:R:E19	R:R:M66	4.06	Yes	No	0	5	6
23	R:R:E19	R:R:L269	6.63	Yes	No	1	5	5
24	R:R:E19	R:R:H272	9.85	Yes	Yes	1	5	7
25	R:R:C25	R:R:F21	4.19	No	No	0	5	4
26	R:R:I22	R:R:M276	4.37	No	Yes	0	7	6
27	R:R:G23	R:R:M66	5.24	No	No	0	6	6
28	R:R:D58	R:R:N30	10.77	Yes	No	0	9	9
29	R:R:N30	R:R:P279	11.4	No	No	0	9	9
30	R:R:F289	R:R:V33	7.87	Yes	No	0	8	9
31	R:R:F289	R:R:V36	7.87	Yes	No	0	8	8
32	R:R:T292	R:R:V36	4.76	No	No	0	7	8
33	R:R:F48	R:R:V37	6.55	Yes	No	0	9	8
34	R:R:V37	R:R:V52	4.81	No	No	0	8	5
35	R:R:L43	R:R:N40	5.49	No	No	0	8	5
36	R:R:N40	R:R:T292	8.77	No	No	0	5	7
37	R:R:K288	R:R:S42	4.59	No	No	0	6	5
38	R:R:F48	R:R:L43	9.74	Yes	No	0	9	8
39	R:R:K288	R:R:L43	7.05	No	No	0	6	8
40	R:R:T46	R:R:Y118	4.99	No	Yes	0	5	8
41	R:R:R111	R:R:T47	9.06	No	No	0	8	8
42	R:R:F48	R:R:I286	8.79	Yes	No	0	9	8
43	R:R:F289	R:R:F48	8.57	Yes	Yes	0	8	9
44	R:R:H124	R:R:Y49	11.98	No	No	0	3	4
45	R:R:W128	R:R:Y49	5.79	No	No	0	1	4
46	R:R:D107	R:R:F50	17.91	No	Yes	0	9	8
47	R:R:F50	R:R:I127	6.28	Yes	No	0	8	6
48	R:R:F50	R:R:L131	6.09	Yes	No	0	8	7
49	R:R:S100	R:R:S53	4.89	No	No	0	7	9
50	R:R:L131	R:R:S53	10.51	No	No	0	7	9
51	R:R:S53	R:R:W135	4.94	No	No	0	9	9
52	R:R:D58	R:R:L54	10.86	Yes	Yes	1	9	9
53	R:R:L54	R:R:S100	4.5	Yes	No	0	9	7
54	R:R:L101	R:R:L54	5.54	Yes	Yes	1	8	9
55	R:R:L54	R:R:N278	12.36	Yes	Yes	1	9	9
56	R:R:D58	R:R:S97	4.42	Yes	No	0	9	9
57	R:R:D58	R:R:S275	4.42	Yes	No	0	9	9
58	R:R:D58	R:R:N278	10.77	Yes	Yes	1	9	9
59	R:R:A60	R:R:F93	6.93	No	Yes	0	6	6
60	R:R:V61	R:R:V65	4.81	Yes	Yes	1	8	7
61	R:R:H272	R:R:V61	4.15	Yes	Yes	1	7	8
62	R:R:S275	R:R:V61	9.7	No	Yes	0	9	8
63	R:R:F93	R:R:L64	7.31	Yes	No	0	6	4
64	R:R:L90	R:R:V65	4.47	No	Yes	0	6	7
65	R:R:F93	R:R:V65	3.93	Yes	Yes	0	6	7
66	R:R:H272	R:R:V65	4.15	Yes	Yes	1	7	7
67	R:R:M66	R:R:P67	8.39	No	No	0	6	8
68	R:R:L68	R:R:M86	8.48	No	No	0	5	6
69	R:R:L68	R:R:L89	4.15	No	No	0	5	5
70	R:R:M86	R:R:V71	4.56	No	No	0	6	4
71	R:R:T87	R:R:V72	4.76	No	No	1	4	5
72	R:R:F168	R:R:V72	3.93	Yes	No	1	5	5
73	R:R:I76	R:R:I78	5.89	No	No	0	2	5
74	R:R:I78	R:R:S82	9.29	No	No	0	5	5
75	R:R:C166	R:R:I78	6.55	No	No	0	9	5
76	R:R:H79	R:R:Y81	6.53	No	No	0	7	1
77	R:R:H79	R:R:T162	6.85	No	No	0	7	3
78	R:R:F80	R:R:Y81	4.13	Yes	No	4	3	1
79	R:R:F80	R:R:K152	6.2	Yes	Yes	4	3	4
80	R:R:F80	R:R:L164	4.87	Yes	No	0	3	4
81	R:R:F80	R:R:V171	9.18	Yes	Yes	0	3	5
82	R:R:K152	R:R:Y81	4.78	Yes	No	4	4	1
83	R:R:C166	R:R:C83	7.28	No	No	0	9	9
84	R:R:C83	R:R:V171	5.12	No	Yes	0	9	5
85	R:R:L84	R:R:M146	4.24	No	No	0	6	5
86	R:R:L84	R:R:N150	5.49	No	No	0	6	5
87	R:R:L84	R:R:V171	4.47	No	Yes	0	6	5
88	R:R:F85	R:R:L89	7.31	No	No	0	5	5
89	R:R:F168	R:R:T87	5.19	Yes	No	1	5	4
90	R:R:M172	R:R:T87	7.53	No	No	1	4	4
91	R:R:C88	R:R:P145	5.65	No	No	0	6	5
92	R:R:C88	R:R:M146	4.86	No	No	0	6	5
93	R:R:L91	R:R:Y176	8.21	No	Yes	0	4	6
94	R:R:L91	R:R:M177	4.24	No	No	0	4	5
95	R:R:F93	R:R:I92	7.54	Yes	No	0	6	5
96	R:R:F139	R:R:I92	11.3	No	No	0	4	5
97	R:R:T94	R:R:W243	6.06	No	Yes	1	6	8
98	R:R:H95	R:R:V141	6.92	Yes	Yes	0	6	4
99	R:R:H95	R:R:S181	6.97	Yes	No	0	6	5
100	R:R:H95	R:R:I186	5.3	Yes	No	0	6	7
101	R:R:A96	R:R:W135	7.78	No	No	0	7	9
102	R:R:F239	R:R:I98	5.02	Yes	No	1	8	8
103	R:R:I98	R:R:W243	18.79	No	Yes	1	8	8
104	R:R:C134	R:R:M99	6.48	No	No	0	7	5
105	R:R:L101	R:R:N274	5.49	Yes	Yes	1	8	9
106	R:R:L101	R:R:N278	4.12	Yes	Yes	1	8	9
107	R:R:L101	R:R:Y282	8.21	Yes	Yes	1	8	9
108	R:R:L102	R:R:P189	8.21	No	No	0	7	8
109	R:R:I104	R:R:R108	7.52	No	No	1	8	9
110	R:R:I104	R:R:Y282	7.25	No	Yes	1	8	9
111	R:R:A105	R:R:Y197	4	No	Yes	0	8	9
112	R:R:D107	R:R:R111	11.91	No	No	3	9	8
113	R:R:D107	R:R:Y118	9.2	No	Yes	3	9	8
114	R:R:R108	R:R:Y197	8.23	No	Yes	0	9	9
115	R:R:R108	R:R:Y282	6.17	No	Yes	1	9	9
116	R:R:K113	R:R:Y109	15.53	No	No	0	6	8
117	R:R:I196	R:R:Y109	14.51	Yes	No	0	6	8
118	R:R:D199	R:R:Y109	9.2	No	No	0	4	8
119	R:R:L110	R:R:L114	8.3	No	No	0	5	5
120	R:R:R111	R:R:Y118	22.64	No	Yes	3	8	8
121	R:R:I200	R:R:V112	6.14	No	No	0	9	9
122	R:R:I203	R:R:V112	4.61	No	No	0	5	9
123	R:R:T122	R:R:Y118	11.24	No	Yes	0	6	8
124	R:R:R126	R:R:T123	7.76	No	No	0	5	8
125	R:R:V137	R:R:W185	6.13	No	Yes	0	4	5
126	R:R:F180	R:R:V141	5.24	Yes	Yes	2	5	4
127	R:R:V141	R:R:W185	12.26	Yes	Yes	2	4	5
128	R:R:T144	R:R:Y176	6.24	No	Yes	2	5	6
129	R:R:F180	R:R:T144	6.49	Yes	No	2	5	5
130	R:R:M172	R:R:P145	6.71	No	No	0	4	5
131	R:R:P145	R:R:Y176	16.69	No	Yes	0	5	6
132	R:R:G148	R:R:N150	5.09	No	No	0	6	5
133	R:R:R173	R:R:W149	9	No	No	0	4	6
134	R:R:W149	R:R:Y176	9.65	No	Yes	2	6	6
135	R:R:F180	R:R:W149	7.02	Yes	No	2	5	6
136	R:R:K152	R:R:N150	4.2	Yes	No	0	4	5
137	R:R:M151	R:R:T154	9.03	No	No	0	4	2
138	R:R:H158	R:R:M151	10.51	No	No	0	2	4
139	R:R:K152	R:R:R159	6.19	Yes	No	0	4	2
140	R:R:L153	R:R:R159	4.86	No	No	0	3	2
141	R:R:R173	R:R:T154	9.06	No	No	0	4	2
142	R:R:H158	R:R:S155	6.97	No	No	0	2	3
143	R:R:H158	R:R:Y157	5.44	No	No	0	2	4
144	R:R:L164	R:R:V161	7.45	No	No	0	4	3
145	R:R:F168	R:R:M172	8.71	Yes	No	1	5	4
146	R:R:S170	R:R:V171	4.85	No	Yes	0	4	5
147	R:R:D175	R:R:R173	13.1	No	No	0	4	4
148	R:R:I253	R:R:M174	4.37	No	No	0	4	3
149	R:R:M174	R:R:Y254	7.18	No	Yes	0	3	4
150	R:R:D175	R:R:Y254	6.9	No	Yes	0	4	4
151	R:R:F180	R:R:Y176	7.22	Yes	Yes	2	5	6
152	R:R:M177	R:R:S181	6.13	No	No	0	5	5
153	R:R:V178	R:R:Y254	7.57	No	Yes	0	5	4
154	R:R:Y179	R:R:Y254	11.91	No	Yes	0	3	4
155	R:R:F180	R:R:W185	13.03	Yes	Yes	2	5	5
156	R:R:F182	R:R:I186	5.02	Yes	No	0	5	7
157	R:R:F182	R:R:S247	17.18	Yes	No	0	5	6
158	R:R:T184	R:R:W185	10.92	No	Yes	0	3	5
159	R:R:F187	R:R:V191	7.87	No	No	0	4	4
160	R:R:F239	R:R:L190	7.31	Yes	No	0	8	6
161	R:R:L190	R:R:L244	4.15	No	No	0	6	6
162	R:R:F239	R:R:M193	4.98	Yes	No	0	8	8
163	R:R:C194	R:R:L236	6.35	No	No	0	4	7
164	R:R:V235	R:R:Y197	6.31	No	Yes	0	8	9
165	R:R:L236	R:R:Y197	7.03	No	Yes	0	7	9
166	R:R:L198	R:R:Y202	4.69	No	No	0	4	3
167	R:R:I200	R:R:L232	4.28	No	Yes	0	9	8
168	R:R:F201	R:R:Y202	5.16	No	No	0	5	3
169	R:R:I204	R:R:T228	9.12	No	No	0	8	7
170	R:R:F233	R:R:F237	13.93	No	No	0	5	4
171	R:R:L234	R:R:L238	4.15	Yes	No	0	6	6
172	R:R:L234	R:R:V281	7.45	Yes	No	0	6	8
173	R:R:V235	R:R:Y282	12.62	No	Yes	0	8	9
174	R:R:F237	R:R:L241	6.09	No	No	0	4	5
175	R:R:F239	R:R:W243	9.02	Yes	Yes	1	8	8
176	R:R:N274	R:R:S242	8.94	Yes	No	0	9	8
177	R:R:N274	R:R:W243	6.78	Yes	Yes	1	9	8
178	R:R:I249	R:R:V259	10.75	No	Yes	0	5	4
179	R:R:I253	R:R:V259	6.14	No	Yes	0	4	4
180	R:R:F255	R:R:Y254	5.16	No	Yes	0	4	4
181	R:R:P260	R:R:V263	5.3	No	No	0	4	4
182	R:R:L264	R:R:Q261	3.99	No	No	0	4	2
183	R:R:Q261	R:R:Y265	15.78	No	Yes	0	2	4
184	R:R:H272	R:R:I268	3.98	Yes	No	1	7	5
185	R:R:H272	R:R:S271	9.76	Yes	No	1	7	7
186	R:R:N274	R:R:N278	8.17	Yes	Yes	1	9	9
187	R:R:M276	R:R:M277	4.33	Yes	No	0	6	6
188	R:R:N278	R:R:Y282	4.65	Yes	Yes	1	9	9
189	R:R:A283	R:R:F289	8.32	No	Yes	0	7	8
190	R:R:K290	R:R:Y284	16.72	No	No	0	8	5
191	R:R:Y284	R:R:Y293	3.97	No	No	0	5	7
192	R:R:V281	R:R:Y282	3.79	No	Yes	0	8	9
193	R:R:F48	R:R:I51	3.77	Yes	No	0	9	8
194	R:R:F93	R:R:L89	3.65	Yes	No	0	6	5
195	R:R:F182	R:R:L183	3.65	Yes	No	0	5	4
196	R:R:L114	R:R:R117	3.64	No	No	0	5	5
197	R:R:K119	R:R:Y118	3.58	No	Yes	0	4	8
198	R:R:P279	R:R:V33	3.53	No	No	0	9	9
199	R:R:P260	R:R:V259	3.53	No	Yes	0	4	4
200	R:R:L232	R:R:Y197	3.52	Yes	Yes	0	8	9
201	R:R:A96	R:R:S138	3.42	No	No	0	7	8
202	R:R:G267	R:R:L246	3.42	No	No	0	6	6
203	R:R:A55	R:R:V33	3.39	No	No	0	9	9
204	R:R:F163	R:R:H79	3.39	No	No	0	2	7
205	R:R:I188	R:R:P189	3.39	No	No	0	4	8
206	R:R:G75	R:R:Q167	3.29	No	No	0	5	5
207	R:R:L270	R:R:P245	3.28	No	No	0	7	9
208	R:R:A55	R:R:I34	3.25	No	No	0	9	7
209	R:R:A105	R:R:I196	3.25	No	Yes	0	8	6
210	R:R:C25	R:R:M276	3.24	No	Yes	0	5	6
211	R:R:F182	R:R:F187	3.22	Yes	No	0	5	4
212	R:R:T115	R:R:V116	3.17	No	No	0	8	6
213	R:R:A240	R:R:L244	3.15	No	No	0	6	6
214	R:R:I16	R:R:S73	3.1	No	No	1	5	5
215	R:R:I70	R:R:S73	3.1	No	No	1	6	5
216	R:R:I59	R:R:V31	3.07	No	No	0	7	4
217	R:R:M99	R:R:S138	3.07	No	No	0	5	8
218	R:R:I196	R:R:V192	3.07	Yes	No	0	6	6
219	R:R:I252	R:R:V259	3.07	No	Yes	0	4	4
220	R:R:A69	R:R:E19	3.02	No	Yes	0	6	5
221	R:R:L56	R:R:V52	2.98	No	No	0	6	5
222	R:R:L102	R:R:V192	2.98	No	No	0	7	6
223	R:R:L133	R:R:V137	2.98	No	No	0	3	4
224	R:R:L232	R:R:T228	2.95	Yes	No	0	8	7
225	R:R:K230	R:R:K285	2.87	No	No	5	7	7
226	R:R:I20	R:R:L24	2.85	No	No	0	4	4
227	R:R:I27	R:R:L24	2.85	No	No	0	6	4
228	R:R:I70	R:R:L74	2.85	No	No	0	6	4
229	R:R:I92	R:R:L143	2.85	No	No	0	5	4
230	R:R:I59	R:R:N30	2.83	No	No	0	7	9
231	R:R:C251	R:R:F182	2.79	No	Yes	0	5	5
232	R:R:A103	R:R:F50	2.77	No	Yes	0	6	8
233	R:R:L136	R:R:L140	2.77	No	No	0	3	4
234	R:R:A229	R:R:F201	2.77	No	No	0	7	5
235	R:R:H124	R:R:T46	2.74	No	No	0	3	5
236	R:R:A11	R:R:Y265	2.67	No	Yes	0	4	4
237	R:R:A57	R:R:W135	2.59	No	No	0	8	9
238	R:R:F201	R:R:L232	2.44	No	Yes	0	5	8
239	R:R:L110	R:R:Y118	2.34	No	Yes	0	5	8
240	R:R:G29	R:R:P279	2.03	No	No	0	8	9
241	R:R:A26	R:R:G23	1.95	No	No	0	7	6
242	R:R:G75	R:R:S165	1.86	No	No	0	5	5
243	R:R:G29	R:R:V28	1.84	No	No	0	8	4
244	R:R:G62	R:R:V61	1.84	No	Yes	0	6	8
245	R:R:G142	R:R:V141	1.84	No	Yes	0	7	4
246	R:R:G23	R:R:I22	1.76	No	No	0	6	7
247	R:R:G62	R:R:I27	1.76	No	No	0	6	6
248	R:R:G257	R:R:I252	1.76	No	No	0	1	4
249	R:R:C35	R:R:V31	1.71	No	No	0	4	4
250	R:R:G267	R:R:L270	1.71	No	No	0	6	7
251	R:R:A11	R:R:T14	1.68	No	No	0	4	4
252	R:R:N40	R:R:P41	1.63	No	No	0	5	6
253	R:R:A273	R:R:M276	1.61	No	Yes	0	6	6
254	R:R:T17	R:R:V13	1.59	No	No	0	6	3
255	R:R:T122	R:R:V121	1.59	No	No	0	6	4
256	R:R:I27	R:R:V63	1.54	No	No	0	6	4
257	R:R:I59	R:R:V63	1.54	No	No	0	7	4
258	R:R:I196	R:R:V106	1.54	Yes	No	0	6	6
259	R:R:M266	R:R:V263	1.52	No	No	0	4	4
260	R:R:N12	R:R:S9	1.49	No	No	0	3	4
261	R:R:I248	R:R:I252	1.47	No	No	0	5	4
262	R:R:I280	R:R:M277	1.46	No	No	0	6	6
263	R:R:E156	R:R:S155	1.44	No	No	0	2	3
264	R:R:Q167	R:R:S170	1.44	No	No	0	5	4
265	R:R:Q44	R:R:V37	1.43	No	No	0	7	8
266	R:R:K230	R:R:L234	1.41	No	Yes	5	7	6
267	R:R:K285	R:R:L234	1.41	No	Yes	5	7	6
268	R:R:L238	R:R:L241	1.38	No	No	0	6	5
269	R:R:R117	R:R:V116	1.31	No	No	0	5	6
270	R:R:R126	R:R:V121	1.31	No	No	0	5	4
271	R:R:F163	R:R:T77	1.3	No	No	0	2	3
272	R:R:R125	R:R:T123	1.29	No	No	0	4	8
273	R:R:F147	R:R:M146	1.24	No	No	0	5	5
274	R:R:N160	R:R:R159	1.21	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.2733	12	1	0
2	R:R:Y15	10.554	5	1	4
3	R:R:E19	7.854	5	1	5
4	R:R:F48	7.484	5	0	9
5	R:R:F50	8.2625	4	0	8
6	R:R:L54	8.315	4	1	9
7	R:R:D58	8.248	5	1	9
8	R:R:V61	5.125	4	1	8
9	R:R:V65	4.34	4	1	7
10	R:R:F80	6.095	4	4	3
11	R:R:F93	5.872	5	0	6
12	R:R:H95	5.9725	4	0	6
13	R:R:L101	5.84	4	1	8
14	R:R:Y118	8.99833	6	3	8
15	R:R:V141	6.565	4	2	4
16	R:R:K152	5.3425	4	4	4
17	R:R:F168	13.1825	4	1	5
18	R:R:V171	5.905	4	0	5
19	R:R:Y176	9.602	5	2	6
20	R:R:F180	7.8	5	2	5
21	R:R:F182	6.372	5	0	5
22	R:R:W185	10.585	4	2	5
23	R:R:I196	5.5925	4	0	6
24	R:R:Y197	5.818	5	0	9
25	R:R:L232	3.2975	4	0	8
26	R:R:L234	3.605	4	5	6
27	R:R:F239	6.5825	4	1	8
28	R:R:W243	9.796	5	1	8
29	R:R:Y254	7.744	5	0	4
30	R:R:V259	5.8725	4	0	4
31	R:R:Y265	11.6525	4	0	4
32	R:R:H272	7.01333	6	1	7
33	R:R:N274	7.345	4	1	9
34	R:R:M276	3.3875	4	0	6
35	R:R:N278	8.014	5	1	9
36	R:R:Y282	7.115	6	1	9
37	R:R:F289	8.1575	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I268	14.4589	6.96	Yes	No	1	0	5
2	R:R:I268	R:R:Y15	17.0987	7.25	No	Yes	1	5	4
3	R:R:Y15	R:R:Y265	12.3436	18.86	Yes	Yes	0	4	4
4	L:L:?1	R:R:H272	33.2648	10.19	Yes	Yes	1	0	7
5	R:R:E19	R:R:H272	21.4426	9.85	Yes	Yes	1	5	7
6	R:R:E19	R:R:M66	13.8601	4.06	Yes	No	0	5	6
7	R:R:G23	R:R:M66	11.3932	5.24	No	No	0	6	6
8	L:L:?1	R:R:W243	98.5788	8.33	Yes	Yes	1	0	8
9	R:R:N274	R:R:W243	100	6.78	Yes	Yes	1	9	8
10	R:R:N274	R:R:N278	56.1852	8.17	Yes	Yes	1	9	9
11	R:R:D58	R:R:N278	24.6782	10.77	Yes	Yes	1	9	9
12	R:R:H272	R:R:V61	27.753	4.15	Yes	Yes	1	7	8
13	R:R:S275	R:R:V61	29.338	9.7	No	Yes	0	9	8
14	R:R:D58	R:R:S275	29.1354	4.42	Yes	No	0	9	9
15	R:R:D58	R:R:N30	36.2412	10.77	Yes	No	0	9	9
16	R:R:N30	R:R:P279	30.6489	11.4	No	No	0	9	9
17	R:R:P279	R:R:V33	26.9575	3.53	No	No	0	9	9
18	R:R:F289	R:R:V33	23.2005	7.87	Yes	No	0	8	9
19	R:R:F289	R:R:F48	15.6507	8.57	Yes	Yes	0	8	9
20	R:R:L101	R:R:N274	44.0085	5.49	Yes	Yes	1	8	9
21	R:R:L101	R:R:L54	20.1555	5.54	Yes	Yes	1	8	9
22	R:R:L54	R:R:S100	47.694	4.5	Yes	No	0	9	7
23	R:R:S100	R:R:S53	46.2162	4.89	No	No	0	7	9
24	R:R:L131	R:R:S53	35.7049	10.51	No	No	0	7	9
25	R:R:F50	R:R:L131	34.1795	6.09	Yes	No	0	8	7
26	R:R:D107	R:R:F50	29.5436	17.91	No	Yes	0	9	8
27	R:R:D107	R:R:Y118	24.994	9.2	No	Yes	3	9	8
28	R:R:L54	R:R:N278	19.9648	12.36	Yes	Yes	1	9	9
29	R:R:F93	R:R:V65	10.4844	3.93	Yes	Yes	0	6	7
30	L:L:?1	R:R:L91	45.5786	6.75	Yes	No	0	0	4
31	R:R:L91	R:R:Y176	44.1962	8.21	No	Yes	0	4	6
32	R:R:P145	R:R:Y176	37.1589	16.69	No	Yes	0	5	6
33	R:R:C88	R:R:P145	69.5835	5.65	No	No	0	6	5
34	R:R:C88	R:R:M146	67.5545	4.86	No	No	0	6	5
35	R:R:L84	R:R:M146	63.4728	4.24	No	No	0	6	5
36	R:R:L84	R:R:V171	38.3298	4.47	No	Yes	0	6	5
37	R:R:C83	R:R:V171	10.9552	5.12	No	Yes	0	9	5
38	L:L:?1	R:R:F168	37.4806	34.9	Yes	Yes	1	0	5
39	R:R:F168	R:R:M172	35.0852	8.71	Yes	No	1	5	4
40	R:R:M172	R:R:P145	34.4655	6.71	No	No	0	4	5
41	R:R:L84	R:R:N150	23.5461	5.49	No	No	0	6	5
42	R:R:K152	R:R:N150	19.2915	4.2	Yes	No	0	4	5
43	R:R:K152	R:R:Y81	10.7645	4.78	Yes	No	4	4	1
44	R:R:H79	R:R:Y81	17.3251	6.53	No	No	0	7	1
45	R:R:F80	R:R:V171	17.4353	9.18	Yes	Yes	0	3	5
46	R:R:F80	R:R:Y81	10.8718	4.13	Yes	No	4	3	1
47	L:L:?1	R:R:H95	17.3132	4.7	Yes	Yes	0	0	6
48	R:R:L101	R:R:Y282	34.5042	8.21	Yes	Yes	1	8	9
49	R:R:R108	R:R:Y282	34.0335	6.17	No	Yes	1	9	9
50	R:R:R108	R:R:Y197	32.8477	8.23	No	Yes	0	9	9
51	R:R:A105	R:R:Y197	29.2665	4	No	Yes	0	8	9
52	R:R:A105	R:R:I196	26.5523	3.25	No	Yes	0	8	6
53	R:R:I196	R:R:V192	11.9384	3.07	Yes	No	0	6	6
54	R:R:N278	R:R:Y282	46.0642	4.65	Yes	Yes	1	9	9
55	R:R:V235	R:R:Y282	33.8666	12.62	No	Yes	0	8	9
56	R:R:V235	R:R:Y197	32.6421	6.31	No	Yes	0	8	9
57	R:R:L232	R:R:Y197	28.7123	3.52	Yes	Yes	0	8	9
58	L:L:?1	R:R:M174	23.5639	6.9	Yes	No	0	0	3
59	R:R:M174	R:R:Y254	12.2959	7.18	No	Yes	0	3	4
60	R:R:R173	R:R:T154	12.0605	9.06	No	No	0	4	2
61	R:R:M151	R:R:T154	10.2908	9.03	No	No	0	4	2
62	R:R:F201	R:R:L232	11.9265	2.44	No	Yes	0	5	8
63	R:R:V281	R:R:Y282	12.4359	3.79	No	Yes	0	8	9
64	R:R:L234	R:R:V281	10.8688	7.45	Yes	No	0	6	8
65	R:R:I253	R:R:M174	10.9552	4.37	No	No	0	4	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L91	6.75	1	Yes	No	0	4	0	1
L:L:?1	R:R:T94	11.68	1	Yes	No	0	6	0	1
L:L:?1	R:R:H95	4.7	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F168	34.9	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V169	6.36	1	Yes	No	0	4	0	1
L:L:?1	R:R:M174	6.9	1	Yes	No	0	3	0	1
L:L:?1	R:R:W243	8.33	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:L246	11.81	1	Yes	No	0	6	0	1
L:L:?1	R:R:N250	9.21	1	Yes	No	0	5	0	1
L:L:?1	R:R:I268	6.96	1	Yes	No	0	5	0	1
L:L:?1	R:R:S271	5.49	1	Yes	No	0	7	0	1
L:L:?1	R:R:H272	10.19	1	Yes	Yes	0	7	0	1
R:R:E19	R:R:Y15	15.71	1	Yes	Yes	5	4	2	2
R:R:I268	R:R:Y15	7.25	1	No	Yes	5	4	1	2
R:R:E19	R:R:H272	9.85	1	Yes	Yes	5	7	2	1
R:R:V61	R:R:V65	4.81	1	Yes	Yes	8	7	2	2
R:R:H272	R:R:V61	4.15	1	Yes	Yes	7	8	1	2
R:R:H272	R:R:V65	4.15	1	Yes	Yes	7	7	1	2
R:R:T87	R:R:V72	4.76	1	No	No	4	5	2	2
R:R:F168	R:R:V72	3.93	1	Yes	No	5	5	1	2
R:R:F168	R:R:T87	5.19	1	Yes	No	5	4	1	2
R:R:M172	R:R:T87	7.53	1	No	No	4	4	2	2
R:R:L91	R:R:Y176	8.21	0	No	Yes	4	6	1	2
R:R:L91	R:R:M177	4.24	0	No	No	4	5	1	2
R:R:T94	R:R:W243	6.06	1	No	Yes	6	8	1	1
R:R:H95	R:R:V141	6.92	0	Yes	Yes	6	4	1	2
R:R:H95	R:R:S181	6.97	0	Yes	No	6	5	1	2
R:R:H95	R:R:I186	5.3	0	Yes	No	6	7	1	2
R:R:F239	R:R:I98	5.02	1	Yes	No	8	8	2	2
R:R:I98	R:R:W243	18.79	1	No	Yes	8	8	2	1
R:R:F168	R:R:M172	8.71	1	Yes	No	5	4	1	2
R:R:I253	R:R:M174	4.37	0	No	No	4	3	2	1
R:R:M174	R:R:Y254	7.18	0	No	Yes	3	4	1	2
R:R:M177	R:R:S181	6.13	0	No	No	5	5	2	2
R:R:F239	R:R:W243	9.02	1	Yes	Yes	8	8	2	1
R:R:N274	R:R:W243	6.78	1	Yes	Yes	9	8	2	1
R:R:H272	R:R:I268	3.98	1	Yes	No	7	5	1	1
R:R:H272	R:R:S271	9.76	1	Yes	No	7	7	1	1
R:R:G267	R:R:L246	3.42	0	No	No	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9EBI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.93
Number of Linked Nodes	248
Number of Links	274
Number of Hubs	37
Number of Links mediated by Hubs	143
Number of Communities	5
Number of Nodes involved in Communities	43
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	67677
Length Of Smallest Path	3
Average Path Length	13.9195
Length of Longest Path	28
Minimum Path Strength	1.45
Average Path Strength	7.19711
Maximum Path Strength	22.055
Minimum Path Correlation	0.7
Average Path Correlation	0.913667
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	39.7272
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8972
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	Q8L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	Q8L
Name	Piclidenoson
Synonyms	(2S,3S,4R,5R)-3,4-dihydroxy-5-(6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-N-methyloxolane-2-carboxamide (non-preferred name)
Identifier
Formula	C18 H19 I N6 O4
Molecular Weight	510.286
SMILES
PubChem	123683
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	4
Total Bonds	51
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P0DMS8
Sequence	>9EBI_nogp_Chain_R S L A N V T Y I T M E I F I G L C A I V G N V L V I C V V K L N P S L Q T T T F Y F I V S L A L A D I A V G V L V M P L A I V V S L G I T I H F Y S C L F M T C L L L I F T H A S I M S L L A I A V D R Y L R V K L T V R Y K R V T T H R R I W L A L G L C W L V S F L V G L T P M F G W N M K L T S E Y H R N V T F L S C Q F V S V M R M D Y M V Y F S F L T W I F I P L V V M C A I Y L D I F Y I I R N K F K T A K S L F L V L F L F A L S W L P L S I I N C I I Y F N G E V P Q L V L Y M G I L L S H A N S M M N P I V Y A Y K I K K F K E T Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8X16	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	Gi1/β1/γ2	3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X16 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8YH0	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-	Gi1/β1/γ2	2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH0 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-		2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-	Gi1/β1/γ2	3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-		3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	9EHS	A	Nucleotide	Adenosine	A_3A	Homo sapiens	LUF7602	-	-	3.2	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	chim(NtGi1L-Gs-CtGi1)/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBH	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBH (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x

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