psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L91	4.22	Yes	Yes	1	0	4
2	L:L:?1	R:R:T94	10.78	Yes	No	1	0	6
3	L:L:?1	R:R:H95	3.14	Yes	Yes	1	0	6
4	L:L:?1	R:R:F168	40.84	Yes	No	0	0	5
5	L:L:?1	R:R:V169	6.36	Yes	No	0	0	4
6	L:L:?1	R:R:M174	4.31	Yes	No	1	0	3
7	L:L:?1	R:R:M177	5.17	Yes	Yes	1	0	5
8	L:L:?1	R:R:W243	3.47	Yes	Yes	1	0	8
9	L:L:?1	R:R:N250	3.35	Yes	No	1	0	5
10	L:L:?1	R:R:I253	6.96	Yes	No	1	0	4
11	L:L:?1	R:R:L264	11.81	Yes	No	0	0	4
12	L:L:?1	R:R:I268	16.53	Yes	Yes	1	0	5
13	L:L:?1	R:R:H272	5.49	Yes	No	1	0	7
14	R:R:I16	R:R:N12	5.66	No	No	0	5	3
15	R:R:N12	R:R:Y265	3.49	No	No	0	3	4
16	R:R:E19	R:R:Y15	6.73	No	Yes	1	5	4
17	R:R:Y15	R:R:Y265	27.8	Yes	No	0	4	4
18	R:R:I268	R:R:Y15	4.84	Yes	Yes	1	5	4
19	R:R:L269	R:R:Y15	7.03	No	Yes	1	5	4
20	R:R:I16	R:R:I70	7.36	No	No	0	5	6
21	R:R:L269	R:R:M18	8.48	No	No	0	5	4
22	R:R:E19	R:R:L269	5.3	No	No	1	5	5
23	R:R:E19	R:R:H272	17.23	No	No	1	5	7
24	R:R:I20	R:R:M66	4.37	No	No	0	4	6
25	R:R:C25	R:R:F21	8.38	No	No	0	5	4
26	R:R:I22	R:R:M276	5.83	No	No	0	7	6
27	R:R:G23	R:R:M66	3.49	No	No	0	6	6
28	R:R:C25	R:R:M276	6.48	No	No	0	5	6
29	R:R:I27	R:R:I59	4.42	No	No	5	6	7
30	R:R:G62	R:R:I27	3.53	No	No	0	6	6
31	R:R:A55	R:R:N30	4.69	No	Yes	0	9	9
32	R:R:D58	R:R:N30	12.12	Yes	Yes	0	9	9
33	R:R:I59	R:R:N30	4.25	No	Yes	0	7	9
34	R:R:N30	R:R:P279	3.26	Yes	No	0	9	9
35	R:R:F289	R:R:V33	9.18	Yes	No	0	8	9
36	R:R:A55	R:R:I34	3.25	No	No	0	9	7
37	R:R:F289	R:R:V36	10.49	Yes	No	2	8	8
38	R:R:T292	R:R:V36	3.17	No	No	2	7	8
39	R:R:L43	R:R:V37	4.47	No	No	2	8	8
40	R:R:F48	R:R:V37	3.93	Yes	No	2	9	8
41	R:R:L39	R:R:N40	4.12	No	No	0	5	5
42	R:R:N40	R:R:T292	4.39	No	No	0	5	7
43	R:R:P41	R:R:Q44	4.74	No	No	0	6	7
44	R:R:F48	R:R:L43	17.05	Yes	No	2	9	8
45	R:R:K288	R:R:L43	4.23	No	No	0	6	8
46	R:R:T45	R:R:T46	4.71	No	Yes	0	7	5
47	R:R:T45	R:R:T47	3.14	No	No	0	7	8
48	R:R:T46	R:R:Y49	3.75	Yes	No	0	5	4
49	R:R:R111	R:R:T46	5.17	Yes	Yes	3	8	5
50	R:R:T46	R:R:Y118	4.99	Yes	Yes	3	5	8
51	R:R:F48	R:R:T47	3.89	Yes	No	0	9	8
52	R:R:R111	R:R:T47	9.06	Yes	No	0	8	8
53	R:R:F48	R:R:I51	11.3	Yes	No	0	9	8
54	R:R:F289	R:R:F48	6.43	Yes	Yes	2	8	9
55	R:R:H124	R:R:Y49	19.6	No	No	0	3	4
56	R:R:I127	R:R:Y49	6.04	No	No	0	6	4
57	R:R:F50	R:R:I104	3.77	Yes	No	0	8	8
58	R:R:D107	R:R:F50	11.94	No	Yes	0	9	8
59	R:R:F50	R:R:I127	7.54	Yes	No	0	8	6
60	R:R:F50	R:R:L131	3.65	Yes	Yes	0	8	7
61	R:R:L131	R:R:S53	9.01	Yes	No	0	7	9
62	R:R:D58	R:R:L54	6.79	Yes	No	0	9	9
63	R:R:L54	R:R:S100	7.51	No	No	0	9	7
64	R:R:L101	R:R:L54	5.54	No	No	0	8	9
65	R:R:L56	R:R:W135	4.56	No	Yes	0	6	9
66	R:R:D58	R:R:S275	7.36	Yes	No	0	9	9
67	R:R:D58	R:R:N278	5.39	Yes	No	0	9	9
68	R:R:A60	R:R:F93	9.71	No	Yes	0	6	6
69	R:R:V61	R:R:V65	3.21	No	No	0	8	7
70	R:R:S275	R:R:V61	6.46	No	No	0	9	8
71	R:R:L64	R:R:V63	5.96	No	No	0	4	4
72	R:R:F93	R:R:L64	6.09	Yes	No	0	6	4
73	R:R:L90	R:R:V65	11.92	No	No	0	6	7
74	R:R:F93	R:R:V65	5.24	Yes	No	0	6	7
75	R:R:M66	R:R:P67	10.06	No	No	0	6	8
76	R:R:L68	R:R:M86	11.31	No	No	0	5	6
77	R:R:L68	R:R:L90	5.54	No	No	0	5	6
78	R:R:I70	R:R:S73	3.1	No	No	0	6	5
79	R:R:T87	R:R:V72	3.17	No	No	0	4	5
80	R:R:S165	R:R:T77	3.2	No	No	0	5	3
81	R:R:I78	R:R:S82	4.64	Yes	No	0	5	5
82	R:R:C83	R:R:I78	4.91	No	Yes	4	9	5
83	R:R:C166	R:R:I78	3.27	No	Yes	4	9	5
84	R:R:F80	R:R:Y81	13.41	Yes	No	0	3	1
85	R:R:F80	R:R:N150	4.83	Yes	No	0	3	5
86	R:R:F80	R:R:V161	5.24	Yes	No	0	3	3
87	R:R:F80	R:R:V171	5.24	Yes	Yes	0	3	5
88	R:R:C166	R:R:C83	7.28	No	No	4	9	9
89	R:R:C83	R:R:V171	3.42	No	Yes	4	9	5
90	R:R:C88	R:R:L84	3.17	No	No	0	6	6
91	R:R:F85	R:R:M146	7.46	No	No	0	5	5
92	R:R:M172	R:R:T87	4.52	No	No	0	4	4
93	R:R:C88	R:R:P145	5.65	No	No	0	6	5
94	R:R:C88	R:R:M146	6.48	No	No	0	6	5
95	R:R:F93	R:R:L89	10.96	Yes	No	0	6	5
96	R:R:H95	R:R:L91	3.86	Yes	Yes	1	6	4
97	R:R:L91	R:R:M172	4.24	Yes	No	0	4	4
98	R:R:L91	R:R:M177	4.24	Yes	Yes	1	4	5
99	R:R:F139	R:R:I92	12.56	No	No	0	4	5
100	R:R:H95	R:R:T94	5.48	Yes	No	1	6	6
101	R:R:T94	R:R:W243	4.85	No	Yes	1	6	8
102	R:R:H95	R:R:V141	6.92	Yes	No	1	6	4
103	R:R:H95	R:R:S181	4.18	Yes	No	0	6	5
104	R:R:H95	R:R:W185	3.17	Yes	Yes	1	6	5
105	R:R:A96	R:R:W135	6.48	No	Yes	0	7	9
106	R:R:A96	R:R:S138	3.42	No	No	0	7	8
107	R:R:I98	R:R:P189	3.39	No	No	0	8	8
108	R:R:I98	R:R:W243	9.4	No	Yes	0	8	8
109	R:R:C134	R:R:M99	4.86	No	No	0	7	5
110	R:R:M99	R:R:W185	4.65	No	Yes	0	5	5
111	R:R:L101	R:R:Y282	4.69	No	Yes	0	8	9
112	R:R:I104	R:R:R108	6.26	No	No	6	8	9
113	R:R:I104	R:R:Y282	4.84	No	Yes	6	8	9
114	R:R:A105	R:R:M193	4.83	No	No	0	8	8
115	R:R:D107	R:R:R111	10.72	No	Yes	3	9	8
116	R:R:D107	R:R:Y118	5.75	No	Yes	3	9	8
117	R:R:R108	R:R:Y282	6.17	No	Yes	6	9	9
118	R:R:K113	R:R:Y109	9.55	No	No	0	6	8
119	R:R:I196	R:R:Y109	9.67	No	No	0	6	8
120	R:R:D199	R:R:Y109	8.05	No	No	0	4	8
121	R:R:R111	R:R:Y118	20.58	Yes	Yes	3	8	8
122	R:R:K113	R:R:L114	11.28	No	No	0	6	5
123	R:R:R117	R:R:V116	7.85	No	No	0	5	6
124	R:R:R117	R:R:R120	3.2	No	No	0	5	5
125	R:R:R117	R:R:V121	3.92	No	No	0	5	4
126	R:R:T122	R:R:Y118	8.74	No	Yes	0	6	8
127	R:R:V137	R:R:W185	3.68	No	Yes	0	4	5
128	R:R:F180	R:R:V141	5.24	Yes	No	1	5	4
129	R:R:V141	R:R:W185	11.03	No	Yes	1	4	5
130	R:R:F147	R:R:L143	3.65	No	No	0	5	4
131	R:R:P145	R:R:T144	5.25	No	No	1	5	5
132	R:R:T144	R:R:Y176	11.24	No	No	1	5	6
133	R:R:F180	R:R:T144	3.89	Yes	No	1	5	5
134	R:R:P145	R:R:Y176	13.91	No	No	1	5	6
135	R:R:K152	R:R:N150	5.6	No	No	0	4	5
136	R:R:M151	R:R:T154	7.53	No	No	0	4	2
137	R:R:H158	R:R:M151	9.19	No	No	0	2	4
138	R:R:K152	R:R:R159	6.19	No	No	0	4	2
139	R:R:S155	R:R:T154	4.8	No	No	0	3	2
140	R:R:R173	R:R:T154	10.35	No	No	0	4	2
141	R:R:E156	R:R:R159	3.49	No	No	0	2	2
142	R:R:L164	R:R:V161	11.92	No	No	0	4	3
143	R:R:F163	R:R:T162	3.89	No	No	0	2	3
144	R:R:C166	R:R:V171	5.12	No	Yes	4	9	5
145	R:R:F168	R:R:M172	11.2	No	No	0	5	4
146	R:R:D175	R:R:R173	15.48	No	No	0	4	4
147	R:R:M174	R:R:N250	5.61	No	No	1	3	5
148	R:R:I253	R:R:M174	4.37	No	No	1	4	3
149	R:R:D175	R:R:Y254	4.6	No	No	0	4	4
150	R:R:F180	R:R:Y176	11.35	Yes	No	1	5	6
151	R:R:M177	R:R:S181	4.6	Yes	No	0	5	5
152	R:R:M177	R:R:N250	4.21	Yes	No	1	5	5
153	R:R:V178	R:R:Y179	3.79	No	No	0	5	3
154	R:R:C251	R:R:V178	3.42	No	No	0	5	5
155	R:R:Y179	R:R:Y254	13.9	No	No	0	3	4
156	R:R:F180	R:R:W185	5.01	Yes	Yes	1	5	5
157	R:R:I186	R:R:S181	3.1	No	No	0	7	5
158	R:R:F182	R:R:L183	4.87	Yes	No	0	5	4
159	R:R:F182	R:R:I186	7.54	Yes	No	0	5	7
160	R:R:F182	R:R:F187	10.72	Yes	No	0	5	4
161	R:R:F182	R:R:S247	13.21	Yes	No	0	5	6
162	R:R:T184	R:R:W185	9.7	No	Yes	0	3	5
163	R:R:F187	R:R:V191	5.24	No	No	0	4	4
164	R:R:I188	R:R:P189	3.39	No	No	0	4	8
165	R:R:F239	R:R:L190	6.09	No	No	0	8	6
166	R:R:F239	R:R:M193	7.46	No	No	0	8	8
167	R:R:L232	R:R:Y197	4.69	No	No	0	8	9
168	R:R:V235	R:R:Y197	3.79	No	No	0	8	9
169	R:R:L198	R:R:Y202	5.86	No	No	0	4	3
170	R:R:E225	R:R:F201	8.16	No	No	0	7	5
171	R:R:E225	R:R:I204	5.47	No	No	0	7	8
172	R:R:N206	R:R:R205	6.03	No	Yes	0	4	5
173	R:R:R205	R:R:S209	6.59	Yes	No	0	5	4
174	R:R:E225	R:R:R205	5.82	No	Yes	0	7	5
175	R:R:K285	R:R:S231	6.12	No	No	0	7	8
176	R:R:L234	R:R:L238	6.92	No	Yes	0	6	6
177	R:R:V235	R:R:Y282	5.05	No	Yes	0	8	9
178	R:R:L238	R:R:M277	8.48	Yes	No	0	6	6
179	R:R:L238	R:R:V281	4.47	Yes	No	0	6	8
180	R:R:F239	R:R:W243	14.03	No	Yes	0	8	8
181	R:R:A240	R:R:L244	3.15	No	No	0	6	6
182	R:R:S242	R:R:W243	3.71	No	Yes	1	8	8
183	R:R:N274	R:R:S242	8.94	No	No	1	9	8
184	R:R:S271	R:R:W243	3.71	No	Yes	0	7	8
185	R:R:N274	R:R:W243	5.65	No	Yes	1	9	8
186	R:R:I268	R:R:L246	5.71	Yes	No	0	5	6
187	R:R:L246	R:R:S271	6.01	No	No	0	6	7
188	R:R:I249	R:R:V259	4.61	No	Yes	0	5	4
189	R:R:I253	R:R:V259	6.14	No	Yes	0	4	4
190	R:R:F255	R:R:Y254	4.13	No	No	0	4	4
191	R:R:E258	R:R:G257	3.27	No	No	0	2	1
192	R:R:P260	R:R:V259	3.53	No	Yes	0	4	4
193	R:R:P260	R:R:V263	10.6	No	No	0	4	4
194	R:R:Q261	R:R:Y265	16.91	No	No	0	2	4
195	R:R:H272	R:R:I268	6.63	No	Yes	1	7	5
196	R:R:N274	R:R:N278	14.98	No	No	0	9	9
197	R:R:N278	R:R:Y282	4.65	No	Yes	0	9	9
198	R:R:V281	R:R:Y282	3.79	No	Yes	0	8	9
199	R:R:K285	R:R:V281	4.55	No	No	0	7	8
200	R:R:A283	R:R:F289	5.55	No	Yes	0	7	8
201	R:R:K290	R:R:Y284	19.11	No	No	0	8	5
202	R:R:F289	R:R:I286	3.77	Yes	No	0	8	8
203	R:R:F289	R:R:T292	3.89	Yes	No	2	8	7
204	R:R:L297	R:R:Y293	3.52	No	No	0	6	7
205	R:R:M86	R:R:S82	3.07	No	No	0	6	5
206	R:R:I200	R:R:V112	3.07	No	No	0	9	9
207	R:R:I203	R:R:V112	3.07	No	No	0	5	9
208	R:R:I196	R:R:V192	3.07	No	No	0	6	6
209	R:R:I252	R:R:V259	3.07	No	Yes	0	4	4
210	R:R:F139	R:R:W135	3.01	No	Yes	0	4	9
211	R:R:L10	R:R:S9	3	No	No	0	4	4
212	R:R:L24	R:R:V28	2.98	No	No	0	4	4
213	R:R:L32	R:R:V28	2.98	No	No	0	6	4
214	R:R:L102	R:R:V192	2.98	No	No	0	7	6
215	R:R:L262	R:R:V263	2.98	No	No	0	2	4
216	R:R:L232	R:R:T228	2.95	No	No	0	8	7
217	R:R:I20	R:R:I70	2.94	No	No	0	4	6
218	R:R:I196	R:R:I200	2.94	No	No	0	6	9
219	R:R:I22	R:R:M18	2.92	No	No	0	7	4
220	R:R:I203	R:R:K207	2.91	No	No	0	5	7
221	R:R:I76	R:R:L74	2.85	No	No	0	2	4
222	R:R:I92	R:R:L143	2.85	No	No	0	5	4
223	R:R:I204	R:R:L208	2.85	No	No	0	8	4
224	R:R:K113	R:R:L110	2.82	No	No	0	6	5
225	R:R:H95	R:R:S138	2.79	Yes	No	0	6	8
226	R:R:A103	R:R:F50	2.77	No	Yes	0	6	8
227	R:R:L136	R:R:L140	2.77	No	No	0	3	4
228	R:R:L190	R:R:L244	2.77	No	No	0	6	6
229	R:R:A229	R:R:F201	2.77	No	No	0	7	5
230	R:R:L241	R:R:L270	2.77	No	No	0	5	7
231	R:R:H79	R:R:T162	2.74	No	No	0	7	3
232	R:R:A57	R:R:W135	2.59	No	Yes	0	8	9
233	R:R:R126	R:R:T123	2.59	No	No	0	5	8
234	R:R:L129	R:R:R125	2.43	No	No	0	1	4
235	R:R:L153	R:R:R173	2.43	No	No	0	3	4
236	R:R:L208	R:R:R224	2.43	No	No	0	4	5
237	R:R:L110	R:R:Y118	2.34	No	Yes	0	5	8
238	R:R:L183	R:R:Y179	2.34	No	No	0	4	3
239	R:R:L131	R:R:W128	2.28	Yes	No	0	7	1
240	R:R:H79	R:R:Y81	2.18	No	No	0	7	1
241	R:R:R125	R:R:R126	2.13	No	No	0	4	5
242	R:R:R205	R:R:Y202	2.06	Yes	No	0	5	3
243	R:R:F147	R:R:W149	2	No	No	0	5	6
244	R:R:G75	R:R:S165	1.86	No	No	0	5	5
245	R:R:G29	R:R:V28	1.84	No	No	0	8	4
246	R:R:G142	R:R:I92	1.76	No	No	0	7	5
247	R:R:A26	R:R:S275	1.71	No	No	0	7	9
248	R:R:C35	R:R:V31	1.71	No	No	0	4	4
249	R:R:A57	R:R:S97	1.71	No	No	0	8	9
250	R:R:G132	R:R:L131	1.71	No	Yes	0	4	7
251	R:R:G267	R:R:L246	1.71	No	No	0	6	6
252	R:R:G148	R:R:N150	1.7	No	No	0	6	5
253	R:R:L244	R:R:P245	1.64	No	No	0	6	9
254	R:R:L270	R:R:P245	1.64	No	No	0	7	9
255	R:R:N40	R:R:P41	1.63	No	No	0	5	6
256	R:R:A273	R:R:I22	1.62	No	No	0	6	7
257	R:R:S170	R:R:V171	1.62	No	Yes	0	4	5
258	R:R:V37	R:R:V52	1.6	No	No	0	8	5
259	R:R:T17	R:R:V13	1.59	No	No	0	6	3
260	R:R:T122	R:R:V121	1.59	No	No	0	6	4
261	R:R:C194	R:R:L236	1.59	No	No	0	4	7
262	R:R:A69	R:R:L90	1.58	No	No	0	6	6
263	R:R:I27	R:R:V31	1.54	No	No	5	6	4
264	R:R:I59	R:R:V31	1.54	No	No	5	7	4
265	R:R:I296	R:R:V36	1.54	No	No	0	5	8
266	R:R:I76	R:R:V71	1.54	No	No	0	2	4
267	R:R:I204	R:R:T228	1.52	No	No	0	8	7
268	R:R:F226	R:R:G223	1.51	No	No	0	4	5
269	R:R:I76	R:R:I78	1.47	No	Yes	0	2	5
270	R:R:G223	R:R:Y222	1.45	No	No	0	5	1
271	R:R:Q167	R:R:S170	1.44	No	No	0	5	4
272	R:R:L270	R:R:M266	1.41	No	No	0	7	4
273	R:R:K290	R:R:L294	1.41	No	No	0	8	4
274	R:R:K298	R:R:L297	1.41	No	No	0	5	6
275	R:R:F163	R:R:T77	1.3	No	No	0	2	3
276	R:R:R126	R:R:T122	1.29	No	No	0	5	6
277	R:R:F226	R:R:K230	1.24	No	No	0	4	7
278	R:R:F237	R:R:L238	1.22	No	Yes	0	4	6
279	R:R:F237	R:R:L241	1.22	No	No	0	4	5
280	R:R:N160	R:R:R159	1.21	No	No	0	4	2
281	R:R:K119	R:R:Y118	1.19	No	Yes	0	4	8
282	R:R:H158	R:R:Y157	1.09	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.41769	13	1	0
2	R:R:Y15	11.6	4	1	4
3	R:R:N30	6.08	4	0	9
4	R:R:T46	4.655	4	3	5
5	R:R:F48	8.52	5	2	9
6	R:R:F50	5.934	5	0	8
7	R:R:D58	7.915	4	0	9
8	R:R:I78	3.5725	4	4	5
9	R:R:F80	7.18	4	0	3
10	R:R:L91	4.14	4	1	4
11	R:R:F93	8	4	0	6
12	R:R:H95	4.22	7	1	6
13	R:R:R111	11.3825	4	3	8
14	R:R:Y118	7.265	6	3	8
15	R:R:L131	4.1625	4	0	7
16	R:R:W135	4.16	4	0	9
17	R:R:V171	3.85	4	4	5
18	R:R:M177	4.555	4	1	5
19	R:R:F180	6.3725	4	1	5
20	R:R:F182	9.085	4	0	5
21	R:R:W185	6.20667	6	1	5
22	R:R:R205	5.125	4	0	5
23	R:R:L238	5.2725	4	0	6
24	R:R:W243	6.40286	7	1	8
25	R:R:V259	4.3375	4	0	4
26	R:R:I268	8.4275	4	1	5
27	R:R:Y282	4.865	6	6	9
28	R:R:F289	6.55167	6	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I268	16.5828	16.53	Yes	Yes	1	0	5
2	R:R:I268	R:R:Y15	15.3492	4.84	Yes	Yes	1	5	4
3	R:R:L269	R:R:M18	10.4722	8.48	No	No	0	5	4
4	L:L:?1	R:R:W243	68.8015	3.47	Yes	Yes	1	0	8
5	R:R:N274	R:R:W243	99.703	5.65	No	Yes	1	9	8
6	R:R:N274	R:R:N278	100	14.98	No	No	0	9	9
7	R:R:D58	R:R:N278	63.5578	5.39	Yes	No	0	9	9
8	R:R:N278	R:R:Y282	71.7144	4.65	No	Yes	0	9	9
9	R:R:I104	R:R:Y282	55.5832	4.84	No	Yes	6	8	9
10	R:R:F50	R:R:I104	55.1134	3.77	Yes	No	0	8	8
11	R:R:D107	R:R:F50	45.7717	11.94	No	Yes	0	9	8
12	R:R:D107	R:R:R111	20.6656	10.72	No	Yes	3	9	8
13	R:R:R111	R:R:T47	19.1622	9.06	Yes	No	0	8	8
14	R:R:F48	R:R:T47	17.3891	3.89	Yes	No	0	9	8
15	R:R:F289	R:R:F48	11.3543	6.43	Yes	Yes	2	8	9
16	R:R:D107	R:R:Y118	24.2726	5.75	No	Yes	3	9	8
17	L:L:?1	R:R:H95	41.9162	3.14	Yes	Yes	1	0	6
18	R:R:H95	R:R:S138	16.3646	2.79	Yes	No	0	6	8
19	R:R:A96	R:R:S138	15.0339	3.42	No	No	0	7	8
20	R:R:A96	R:R:W135	13.6973	6.48	No	Yes	0	7	9
21	R:R:D58	R:R:S275	55.3134	7.36	Yes	No	0	9	9
22	R:R:S275	R:R:V61	53.7312	6.46	No	No	0	9	8
23	R:R:V61	R:R:V65	52.931	3.21	No	No	0	8	7
24	R:R:L90	R:R:V65	48.0025	11.92	No	No	0	6	7
25	R:R:L68	R:R:L90	46.2961	5.54	No	No	0	5	6
26	R:R:L68	R:R:M86	45.4444	11.31	No	No	0	5	6
27	R:R:M86	R:R:S82	44.5835	3.07	No	No	0	6	5
28	R:R:I78	R:R:S82	43.7167	4.64	Yes	No	0	5	5
29	R:R:C83	R:R:I78	20.0928	4.91	No	Yes	4	9	5
30	R:R:C83	R:R:V171	19.1349	3.42	No	Yes	4	9	5
31	R:R:F80	R:R:V171	32.5321	5.24	Yes	Yes	0	3	5
32	R:R:F80	R:R:Y81	14.5096	13.41	Yes	No	0	3	1
33	R:R:H79	R:R:Y81	12.4545	2.18	No	No	0	7	1
34	R:R:H79	R:R:T162	10.3934	2.74	No	No	0	7	3
35	R:R:C166	R:R:I78	20.0928	3.27	No	Yes	4	9	5
36	R:R:C166	R:R:V171	19.1349	5.12	No	Yes	4	9	5
37	R:R:H95	R:R:V141	17.9741	6.92	Yes	No	1	6	4
38	R:R:F180	R:R:V141	16.7101	5.24	Yes	No	1	5	4
39	R:R:F180	R:R:T144	15.3219	3.89	Yes	No	1	5	5
40	R:R:P145	R:R:T144	12.8758	5.25	No	No	1	5	5
41	R:R:C88	R:R:P145	20.511	5.65	No	No	0	6	5
42	R:R:H95	R:R:W185	22.8571	3.17	Yes	Yes	1	6	5
43	R:R:F180	R:R:W185	16.5373	5.01	Yes	Yes	1	5	5
44	R:R:F180	R:R:Y176	15.334	11.35	Yes	No	1	5	6
45	R:R:P145	R:R:Y176	12.7182	13.91	No	No	1	5	6
46	R:R:C88	R:R:M146	10.5389	6.48	No	No	0	6	5
47	L:L:?1	R:R:M177	13.7518	5.17	Yes	Yes	1	0	5
48	R:R:M177	R:R:S181	13.5215	4.6	Yes	No	0	5	5
49	R:R:L110	R:R:Y118	12.891	2.34	No	Yes	0	5	8
50	R:R:K113	R:R:L110	11.8362	2.82	No	No	0	6	5
51	R:R:F80	R:R:N150	12.2545	4.83	Yes	No	0	3	5
52	R:R:H95	R:R:S181	26.2185	4.18	Yes	No	0	6	5
53	R:R:I186	R:R:S181	37.6788	3.1	No	No	0	7	5
54	R:R:F182	R:R:I186	35.7299	7.54	Yes	No	0	5	7
55	R:R:F182	R:R:L183	27.8734	4.87	Yes	No	0	5	4
56	R:R:L183	R:R:Y179	25.8942	2.34	No	No	0	4	3
57	R:R:Y179	R:R:Y254	19.92	13.9	No	No	0	3	4
58	R:R:D175	R:R:Y254	16.0827	4.6	No	No	0	4	4
59	R:R:D175	R:R:R173	14.067	15.48	No	No	0	4	4
60	R:R:R173	R:R:T154	10.2267	10.35	No	No	0	4	2
61	R:R:V235	R:R:Y282	15.8705	5.05	No	Yes	0	8	9
62	R:R:V235	R:R:Y197	14.8672	3.79	No	No	0	8	9
63	R:R:L232	R:R:Y197	13.961	4.69	No	No	0	8	9
64	R:R:L232	R:R:T228	12.9001	2.95	No	No	0	8	7
65	R:R:I204	R:R:T228	11.9756	1.52	No	No	0	8	7
66	R:R:H95	R:R:T94	33.7445	5.48	Yes	No	1	6	6
67	R:R:T94	R:R:W243	34.0658	4.85	No	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L91	4.22	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:T94	10.78	1	Yes	No	0	6	0	1
L:L:?1	R:R:H95	3.14	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F168	40.84	1	Yes	No	0	5	0	1
L:L:?1	R:R:V169	6.36	1	Yes	No	0	4	0	1
L:L:?1	R:R:M174	4.31	1	Yes	No	0	3	0	1
L:L:?1	R:R:M177	5.17	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W243	3.47	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N250	3.35	1	Yes	No	0	5	0	1
L:L:?1	R:R:I253	6.96	1	Yes	No	0	4	0	1
L:L:?1	R:R:L264	11.81	1	Yes	No	0	4	0	1
L:L:?1	R:R:I268	16.53	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:H272	5.49	1	Yes	No	0	7	0	1
R:R:E19	R:R:Y15	6.73	1	No	Yes	5	4	2	2
R:R:I268	R:R:Y15	4.84	1	Yes	Yes	5	4	1	2
R:R:E19	R:R:H272	17.23	1	No	No	5	7	2	1
R:R:H95	R:R:L91	3.86	1	Yes	Yes	6	4	1	1
R:R:L91	R:R:M172	4.24	1	Yes	No	4	4	1	2
R:R:L91	R:R:M177	4.24	1	Yes	Yes	4	5	1	1
R:R:H95	R:R:T94	5.48	1	Yes	No	6	6	1	1
R:R:T94	R:R:W243	4.85	1	No	Yes	6	8	1	1
R:R:H95	R:R:V141	6.92	1	Yes	No	6	4	1	2
R:R:H95	R:R:S181	4.18	1	Yes	No	6	5	1	2
R:R:H95	R:R:W185	3.17	1	Yes	Yes	6	5	1	2
R:R:I98	R:R:W243	9.4	0	No	Yes	8	8	2	1
R:R:V141	R:R:W185	11.03	1	No	Yes	4	5	2	2
R:R:F168	R:R:M172	11.2	0	No	No	5	4	1	2
R:R:M174	R:R:N250	5.61	1	No	No	3	5	1	1
R:R:I253	R:R:M174	4.37	1	No	No	4	3	1	1
R:R:M177	R:R:S181	4.6	1	Yes	No	5	5	1	2
R:R:M177	R:R:N250	4.21	1	Yes	No	5	5	1	1
R:R:F239	R:R:W243	14.03	0	No	Yes	8	8	2	1
R:R:S242	R:R:W243	3.71	1	No	Yes	8	8	2	1
R:R:N274	R:R:S242	8.94	1	No	No	9	8	2	2
R:R:S271	R:R:W243	3.71	0	No	Yes	7	8	2	1
R:R:N274	R:R:W243	5.65	1	No	Yes	9	8	2	1
R:R:I268	R:R:L246	5.71	1	Yes	No	5	6	1	2
R:R:L246	R:R:S271	6.01	0	No	No	6	7	2	2
R:R:I253	R:R:V259	6.14	1	No	Yes	4	4	1	2
R:R:H272	R:R:I268	6.63	1	No	Yes	7	5	1	1
R:R:H95	R:R:S138	2.79	1	Yes	No	6	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X16_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	262
Number of Links	282
Number of Hubs	28
Number of Links mediated by Hubs	120
Number of Communities	6
Number of Nodes involved in Communities	42
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	54875
Length Of Smallest Path	3
Average Path Length	15.5983
Length of Longest Path	36
Minimum Path Strength	1.22
Average Path Strength	6.33206
Maximum Path Strength	28.685
Minimum Path Correlation	0.7
Average Path Correlation	0.923888
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.0223
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.6434
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	Q8L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	Q8L
Name	Piclidenoson
Synonyms	(2S,3S,4R,5R)-3,4-dihydroxy-5-(6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-N-methyloxolane-2-carboxamide (non-preferred name)
Identifier
Formula	C18 H19 I N6 O4
Molecular Weight	510.286
SMILES
PubChem	123683
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	4
Total Bonds	51
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P0DMS8
Sequence	>8X16_nogp_Chain_R S L A N V T Y I T M E I F I G L C A I V G N V L V I C V V K L N P S L Q T T T F Y F I V S L A L A D I A V G V L V M P L A I V V S L G I T I H F Y S C L F M T C L L L I F T H A S I M S L L A I A V D R Y L R V K L T V R Y K R V T T H R R I W L A L G L C W L V S F L V G L T P M F G W N M K L T S E Y H R N V T F L S C Q F V S V M R M D Y M V Y F S F L T W I F I P L V V M C A I Y L D I F Y I I R N K L S L Y G R E F K T A K S L F L V L F L F A L S W L P L S I I N C I I Y F N G E V P Q L V L Y M G I L L S H A N S M M N P I V Y A Y K I K K F K E T Y L L I L K A C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8X16	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	Gi1/β1/γ2	3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X16 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8YH0	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-	Gi1/β1/γ2	2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH0 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-		2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-	Gi1/β1/γ2	3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-		3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	9EBH	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBH (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	chim(NtGi1L-Gs-CtGi1)/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EHS	A	Nucleotide	Adenosine	A_3A	Homo sapiens	LUF7602	-	-	3.2	2025-08-20	doi.org/10.1038/s41467-025-62872-x

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8X16_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.