psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S9	R:R:T11	4.8	No	No	0	4	4
2	R:R:S12	R:R:S9	3.26	No	No	0	3	4
3	R:R:T11	R:R:Y265	3.75	No	Yes	0	4	4
4	R:R:S12	R:R:Y265	3.82	No	Yes	0	3	4
5	R:R:E19	R:R:Y15	7.86	Yes	Yes	1	5	4
6	R:R:S73	R:R:Y15	5.09	No	Yes	0	5	4
7	R:R:Y15	R:R:Y265	26.81	Yes	Yes	0	4	4
8	R:R:I268	R:R:Y15	12.09	Yes	Yes	1	5	4
9	R:R:L269	R:R:Y15	5.86	No	Yes	1	5	4
10	R:R:I16	R:R:I70	5.89	No	No	0	5	6
11	R:R:L269	R:R:V18	11.92	No	No	0	5	4
12	R:R:E19	R:R:I268	4.1	Yes	Yes	1	5	5
13	R:R:E19	R:R:L269	5.3	Yes	No	1	5	5
14	R:R:E19	R:R:H272	16	Yes	Yes	1	5	7
15	R:R:A273	R:R:I22	4.87	No	No	0	6	7
16	R:R:I22	R:R:M276	10.2	No	No	0	7	6
17	R:R:C25	R:R:M276	6.48	No	No	0	5	6
18	R:R:A26	R:R:S275	3.42	No	No	0	7	9
19	R:R:G62	R:R:I27	3.53	No	No	0	6	6
20	R:R:D58	R:R:N30	12.12	Yes	No	0	9	9
21	R:R:I59	R:R:N30	5.66	No	No	0	7	9
22	R:R:N30	R:R:P279	4.89	No	No	0	9	9
23	R:R:F289	R:R:V33	7.87	No	No	0	8	9
24	R:R:L39	R:R:W35	18.22	No	No	0	5	4
25	R:R:I296	R:R:W35	4.7	No	No	0	5	4
26	R:R:F289	R:R:V36	13.11	No	No	0	8	8
27	R:R:T292	R:R:V36	4.76	Yes	No	0	7	8
28	R:R:V37	R:R:V52	4.81	No	No	0	8	5
29	R:R:L43	R:R:N40	4.12	Yes	No	4	8	5
30	R:R:N40	R:R:T292	16.08	No	Yes	4	5	7
31	R:R:F48	R:R:L43	13.4	Yes	Yes	0	9	8
32	R:R:K288	R:R:L43	4.23	No	Yes	0	6	8
33	R:R:L43	R:R:T292	4.42	Yes	Yes	4	8	7
34	R:R:R111	R:R:T46	5.17	Yes	No	3	8	5
35	R:R:T46	R:R:Y118	4.99	No	Yes	3	5	8
36	R:R:I127	R:R:T46	4.56	No	No	0	6	5
37	R:R:F48	R:R:T47	6.49	Yes	No	0	9	8
38	R:R:R111	R:R:T47	6.47	Yes	No	0	8	8
39	R:R:Q124	R:R:Y49	9.02	No	No	5	3	4
40	R:R:I127	R:R:Y49	6.04	No	No	0	6	4
41	R:R:W128	R:R:Y49	8.68	No	No	5	1	4
42	R:R:D107	R:R:F50	11.94	No	No	0	9	8
43	R:R:F50	R:R:L131	4.87	No	No	0	8	7
44	R:R:S100	R:R:S53	3.26	No	No	0	7	9
45	R:R:L131	R:R:S53	6.01	No	No	0	7	9
46	R:R:D58	R:R:L54	5.43	Yes	Yes	2	9	9
47	R:R:L54	R:R:S100	6.01	Yes	No	0	9	7
48	R:R:I104	R:R:L54	4.28	No	Yes	2	8	9
49	R:R:L54	R:R:N278	6.87	Yes	Yes	2	9	9
50	R:R:D58	R:R:S275	4.42	Yes	No	0	9	9
51	R:R:D58	R:R:N278	6.73	Yes	Yes	2	9	9
52	R:R:A60	R:R:F93	4.16	No	Yes	0	6	6
53	R:R:S275	R:R:V61	6.46	No	No	0	9	8
54	R:R:F93	R:R:L64	10.96	Yes	No	0	6	4
55	R:R:M90	R:R:V65	9.13	Yes	No	0	6	7
56	R:R:F93	R:R:V65	3.93	Yes	No	0	6	7
57	R:R:H272	R:R:V65	4.15	Yes	No	0	7	7
58	R:R:M66	R:R:P67	11.74	Yes	No	0	6	8
59	R:R:L68	R:R:M86	4.24	No	No	0	5	6
60	R:R:L68	R:R:L89	4.15	No	No	0	5	5
61	R:R:L68	R:R:M90	4.24	No	Yes	0	5	6
62	R:R:C166	R:R:I72	3.27	No	No	0	9	5
63	R:R:P165	R:R:T77	3.5	No	No	0	5	3
64	R:R:C83	R:R:I78	3.27	No	No	6	9	5
65	R:R:C166	R:R:I78	6.55	No	No	6	9	5
66	R:R:H79	R:R:Y81	3.27	No	No	0	7	1
67	R:R:H79	R:R:T162	4.11	No	No	7	7	3
68	R:R:F163	R:R:H79	9.05	No	No	7	2	7
69	R:R:F80	R:R:Y81	9.28	Yes	No	0	3	1
70	R:R:F80	R:R:N150	9.67	Yes	Yes	8	3	5
71	R:R:F80	R:R:K152	6.2	Yes	No	8	3	4
72	R:R:F80	R:R:L164	3.65	Yes	No	0	3	4
73	R:R:F80	R:R:V171	7.87	Yes	No	0	3	5
74	R:R:C166	R:R:C83	7.28	No	No	6	9	9
75	R:R:C83	R:R:V171	6.83	No	No	0	9	5
76	R:R:L84	R:R:T87	4.42	No	Yes	0	6	4
77	R:R:L84	R:R:M146	4.24	No	Yes	0	6	5
78	R:R:L84	R:R:N150	5.49	No	Yes	0	6	5
79	R:R:F85	R:R:L89	9.74	No	No	0	5	5
80	R:R:F85	R:R:M146	3.73	No	Yes	0	5	5
81	R:R:F168	R:R:T87	5.19	Yes	Yes	1	5	4
82	R:R:T87	R:R:V171	4.76	Yes	No	0	4	5
83	R:R:M172	R:R:T87	4.52	Yes	Yes	1	4	4
84	R:R:C88	R:R:P145	5.65	No	Yes	0	6	5
85	R:R:C88	R:R:M146	4.86	No	Yes	0	6	5
86	R:R:F93	R:R:L89	9.74	Yes	No	0	6	5
87	L:L:?1	R:R:M90	6.45	Yes	Yes	0	0	6
88	R:R:H95	R:R:L91	5.14	Yes	Yes	1	6	4
89	R:R:G142	R:R:L91	5.13	No	Yes	0	7	4
90	R:R:L91	R:R:M172	4.24	Yes	Yes	1	4	4
91	R:R:L91	R:R:Y176	10.55	Yes	Yes	1	4	6
92	R:R:F93	R:R:I92	11.3	Yes	Yes	0	6	5
93	R:R:F139	R:R:I92	6.28	No	Yes	0	4	5
94	R:R:G142	R:R:I92	3.53	No	Yes	0	7	5
95	R:R:H95	R:R:T94	4.11	Yes	No	0	6	6
96	R:R:T94	R:R:W243	3.64	No	Yes	0	6	8
97	R:R:H95	R:R:V141	6.92	Yes	No	1	6	4
98	R:R:H95	R:R:S181	6.97	Yes	No	0	6	5
99	R:R:H95	R:R:W185	4.23	Yes	Yes	1	6	5
100	R:R:A96	R:R:W135	5.19	No	No	0	7	9
101	R:R:A96	R:R:S138	3.42	No	No	0	7	8
102	R:R:I98	R:R:P189	3.39	No	No	0	8	8
103	R:R:F239	R:R:I98	6.28	Yes	No	2	8	8
104	R:R:I98	R:R:W243	10.57	No	Yes	2	8	8
105	R:R:M99	R:R:W185	4.65	No	Yes	0	5	5
106	R:R:L101	R:R:N278	9.61	No	Yes	0	8	9
107	R:R:L101	R:R:Y282	7.03	No	Yes	0	8	9
108	R:R:L102	R:R:V192	7.45	No	No	0	7	6
109	R:R:I104	R:R:R108	5.01	No	No	2	8	9
110	R:R:I104	R:R:Y282	6.04	No	Yes	2	8	9
111	R:R:A105	R:R:Y197	4	No	Yes	0	8	9
112	R:R:D107	R:R:R111	13.1	No	Yes	3	9	8
113	R:R:D107	R:R:Y118	5.75	No	Yes	3	9	8
114	R:R:R108	R:R:Y197	6.17	No	Yes	2	9	9
115	R:R:R108	R:R:Y282	6.17	No	Yes	2	9	9
116	R:R:K113	R:R:Y109	5.97	No	No	0	6	8
117	R:R:I196	R:R:Y109	3.63	No	No	0	6	8
118	R:R:D199	R:R:Y109	4.6	No	No	0	4	8
119	R:R:L110	R:R:L114	4.15	No	Yes	0	5	5
120	R:R:R111	R:R:Y118	19.55	Yes	Yes	3	8	8
121	R:R:I200	R:R:V112	6.14	No	No	0	9	9
122	R:R:I203	R:R:V112	4.61	No	No	0	5	9
123	R:R:L114	R:R:Y118	3.52	Yes	Yes	0	5	8
124	R:R:L114	R:R:V121	4.47	Yes	No	0	5	4
125	R:R:R117	R:R:T115	5.17	No	No	0	5	8
126	R:R:T122	R:R:Y118	14.98	No	Yes	0	6	8
127	R:R:R126	R:R:T123	5.17	No	No	0	5	8
128	R:R:Q124	R:R:W128	4.38	No	No	5	3	1
129	R:R:V137	R:R:W185	4.9	No	Yes	0	4	5
130	R:R:F180	R:R:V141	5.24	No	No	1	5	4
131	R:R:V141	R:R:W185	14.71	No	Yes	1	4	5
132	R:R:P145	R:R:T144	3.5	Yes	No	0	5	5
133	R:R:M172	R:R:P145	5.03	Yes	Yes	1	4	5
134	R:R:P145	R:R:Y176	12.52	Yes	Yes	1	5	6
135	R:R:K152	R:R:N150	4.2	No	Yes	8	4	5
136	R:R:L161	R:R:L164	5.54	No	No	0	3	4
137	R:R:F163	R:R:T162	6.49	No	No	7	2	3
138	R:R:L164	R:R:P165	3.28	No	No	0	4	5
139	R:R:R167	R:R:S170	5.27	No	No	0	5	4
140	R:R:F168	R:R:M172	7.46	Yes	Yes	1	5	4
141	R:R:F168	R:R:M177	8.71	Yes	No	1	5	5
142	L:L:?1	R:R:F168	26.18	Yes	Yes	1	0	5
143	R:R:M174	R:R:R169	8.69	No	No	0	3	4
144	R:R:L253	R:R:R169	4.86	No	No	0	4	4
145	R:R:M172	R:R:Y176	7.18	Yes	Yes	1	4	6
146	R:R:M174	R:R:N250	5.61	No	No	0	3	5
147	R:R:M174	R:R:Y254	5.99	No	Yes	0	3	4
148	R:R:D175	R:R:Y254	13.79	No	Yes	0	4	4
149	R:R:M177	R:R:Y176	5.99	No	Yes	1	5	6
150	R:R:F180	R:R:Y176	9.28	No	Yes	1	5	6
151	L:L:?1	R:R:M177	5.52	Yes	No	1	0	5
152	R:R:C251	R:R:V178	3.42	No	No	0	5	5
153	R:R:V178	R:R:Y254	5.05	No	Yes	0	5	4
154	R:R:F180	R:R:W185	5.01	No	Yes	1	5	5
155	R:R:F182	R:R:I186	7.54	Yes	No	0	5	7
156	R:R:F182	R:R:L187	4.87	Yes	No	0	5	4
157	R:R:F182	R:R:S247	17.18	Yes	No	0	5	6
158	R:R:L184	R:R:W185	11.39	No	Yes	0	3	5
159	R:R:P189	R:R:V188	3.53	No	No	0	8	4
160	R:R:F239	R:R:L190	9.74	Yes	No	0	8	6
161	R:R:C194	R:R:L236	6.35	No	No	0	4	7
162	R:R:L232	R:R:Y197	15.24	No	Yes	0	8	9
163	R:R:V235	R:R:Y197	6.31	No	Yes	2	8	9
164	R:R:L236	R:R:Y197	4.69	No	Yes	0	7	9
165	R:R:Y197	R:R:Y282	3.97	Yes	Yes	2	9	9
166	R:R:D199	R:R:I203	4.2	No	No	0	4	5
167	R:R:A229	R:R:F201	5.55	No	No	0	7	5
168	R:R:I204	R:R:T228	4.56	No	No	0	8	7
169	R:R:E225	R:R:R205	6.98	No	No	0	7	5
170	R:R:E225	R:R:F226	3.5	No	No	0	7	4
171	R:R:K285	R:R:S231	6.12	No	No	0	7	8
172	R:R:L234	R:R:V281	10.43	No	No	0	6	8
173	R:R:V235	R:R:Y282	12.62	No	Yes	2	8	9
174	R:R:F237	R:R:L238	3.65	No	No	0	4	6
175	R:R:F237	R:R:L241	12.18	No	No	0	4	5
176	R:R:L238	R:R:M277	5.65	No	No	0	6	6
177	R:R:L238	R:R:V281	4.47	No	No	0	6	8
178	R:R:F239	R:R:W243	13.03	Yes	Yes	2	8	8
179	R:R:F239	R:R:N274	4.83	Yes	Yes	2	8	9
180	R:R:C242	R:R:N274	7.87	No	Yes	0	8	9
181	R:R:S271	R:R:W243	11.12	No	Yes	0	7	8
182	R:R:N274	R:R:W243	7.91	Yes	Yes	2	9	8
183	R:R:L270	R:R:P245	8.21	No	No	0	7	9
184	R:R:G267	R:R:L246	3.42	No	No	0	6	6
185	L:L:?1	R:R:L246	13.52	Yes	No	0	0	6
186	R:R:I249	R:R:V263	4.61	No	No	0	5	4
187	L:L:?1	R:R:N250	14.31	Yes	No	0	0	5
188	R:R:L253	R:R:V259	4.47	No	Yes	0	4	4
189	R:R:F255	R:R:Y254	11.35	No	Yes	0	4	4
190	R:R:G257	R:R:Q258	3.29	No	No	0	1	2
191	R:R:P260	R:R:V259	3.53	No	Yes	9	4	4
192	R:R:V259	R:R:V263	4.81	Yes	No	9	4	4
193	R:R:P260	R:R:V263	5.3	No	No	9	4	4
194	R:R:L264	R:R:Q261	9.32	No	No	0	4	2
195	R:R:Q261	R:R:Y265	19.16	No	Yes	0	2	4
196	L:L:?1	R:R:L264	9.92	Yes	No	0	0	4
197	R:R:H272	R:R:I268	6.63	Yes	Yes	1	7	5
198	L:L:?1	R:R:I268	11.16	Yes	Yes	1	0	5
199	L:L:?1	R:R:H272	6.7	Yes	Yes	1	0	7
200	R:R:N274	R:R:N278	10.9	Yes	Yes	2	9	9
201	R:R:A283	R:R:F289	8.32	No	No	0	7	8
202	R:R:K290	R:R:Y284	16.72	No	No	0	8	5
203	R:R:Y284	R:R:Y293	4.96	No	No	10	5	7
204	R:R:I286	R:R:K288	4.36	No	No	0	8	6
205	R:R:E291	R:R:K287	8.1	No	No	0	5	5
206	R:R:A55	R:R:I34	3.25	No	No	0	9	7
207	R:R:S97	R:R:V61	3.23	No	No	0	9	8
208	R:R:A69	R:R:M90	3.22	No	Yes	0	6	6
209	R:R:A105	R:R:M193	3.22	No	No	0	8	8
210	R:R:T115	R:R:V116	3.17	No	No	0	8	6
211	R:R:A240	R:R:L190	3.15	No	No	0	6	6
212	R:R:R119	R:R:Y118	3.09	No	Yes	0	4	8
213	R:R:F183	R:R:Y179	3.09	No	No	0	4	3
214	R:R:I22	R:R:V18	3.07	No	No	0	7	4
215	R:R:I34	R:R:V52	3.07	No	No	0	7	5
216	R:R:I78	R:R:V76	3.07	No	No	0	5	2
217	R:R:M99	R:R:S138	3.07	No	No	0	5	8
218	R:R:I196	R:R:V192	3.07	No	No	0	6	6
219	R:R:K38	R:R:V37	3.04	No	No	0	1	8
220	R:R:M86	R:R:V71	3.04	No	No	0	6	4
221	R:R:I296	R:R:T292	3.04	No	Yes	0	5	7
222	R:R:L74	R:R:S73	3	No	No	0	4	5
223	R:R:L32	R:R:V28	2.98	No	No	0	6	4
224	R:R:L64	R:R:V63	2.98	No	No	0	4	4
225	R:R:L102	R:R:V106	2.98	No	No	0	7	6
226	R:R:L110	R:R:V106	2.98	No	No	0	5	6
227	R:R:L133	R:R:V137	2.98	No	No	0	3	4
228	R:R:L21	R:R:T17	2.95	No	No	0	4	6
229	R:R:L232	R:R:T228	2.95	No	No	0	8	7
230	R:R:I20	R:R:M66	2.92	No	Yes	0	4	6
231	R:R:I34	R:R:L56	2.85	No	No	0	7	6
232	R:R:I92	R:R:L143	2.85	Yes	No	0	5	4
233	R:R:I204	R:R:L208	2.85	No	No	0	8	4
234	R:R:L24	R:R:M66	2.83	No	Yes	0	4	6
235	R:R:A103	R:R:F50	2.77	No	No	0	6	8
236	R:R:L190	R:R:L244	2.77	No	No	0	6	6
237	R:R:R173	R:R:S154	2.64	No	No	0	4	2
238	R:R:F48	R:R:T45	2.59	Yes	No	0	9	7
239	R:R:A57	R:R:W135	2.59	No	No	0	8	9
240	R:R:V36	R:R:Y293	2.52	No	No	0	8	7
241	R:R:F48	R:R:I51	2.51	Yes	No	0	9	8
242	R:R:F147	R:R:M146	2.49	No	Yes	0	5	5
243	R:R:M151	R:R:R173	2.48	No	No	0	4	4
244	R:R:F182	R:R:L244	2.44	Yes	No	0	5	6
245	R:R:F183	R:R:L184	2.44	No	No	0	4	3
246	R:R:T144	R:R:W149	2.43	No	No	0	5	6
247	R:R:I203	R:R:Y202	2.42	No	No	0	5	3
248	R:R:D175	R:R:R173	2.38	No	No	0	4	4
249	R:R:N206	R:R:Y202	2.33	No	No	0	4	3
250	R:R:G23	R:R:G62	2.11	No	No	0	6	6
251	R:R:G267	R:R:P245	2.03	No	No	0	6	9
252	R:R:A26	R:R:G23	1.95	No	No	0	7	6
253	R:R:G29	R:R:V28	1.84	No	No	0	8	4
254	R:R:G257	R:R:I252	1.76	No	No	0	1	4
255	R:R:G23	R:R:M66	1.75	No	Yes	0	6	6
256	R:R:G132	R:R:L131	1.71	No	No	0	4	7
257	R:R:A55	R:R:V33	1.7	No	No	0	9	9
258	R:R:I280	R:R:P279	1.69	No	No	0	6	9
259	R:R:N40	R:R:P41	1.63	No	No	0	5	6
260	R:R:C134	R:R:M99	1.62	No	No	0	7	5
261	R:R:V235	R:R:V281	1.6	No	No	0	8	8
262	R:R:T17	R:R:V13	1.59	No	No	0	6	3
263	R:R:T14	R:R:V18	1.59	No	No	0	4	4
264	R:R:T11	R:R:T262	1.57	No	No	0	4	2
265	R:R:I27	R:R:V31	1.54	No	No	0	6	4
266	R:R:I59	R:R:V31	1.54	No	No	0	7	4
267	R:R:I252	R:R:V259	1.54	No	Yes	0	4	4
268	R:R:L187	R:R:V191	1.49	No	No	0	4	4
269	R:R:L140	R:R:T144	1.47	No	No	0	4	5
270	R:R:I248	R:R:I252	1.47	No	No	0	5	4
271	R:R:I70	R:R:M66	1.46	No	Yes	0	6	6
272	R:R:I20	R:R:L21	1.43	No	No	0	4	4
273	R:R:K285	R:R:L234	1.41	No	No	0	7	6
274	R:R:L153	R:R:N150	1.37	No	Yes	0	3	5
275	R:R:D158	R:R:L161	1.36	No	No	0	2	3
276	R:R:E159	R:R:K152	1.35	No	No	0	2	4
277	R:R:E225	R:R:L208	1.33	No	No	0	7	4
278	R:R:F201	R:R:T228	1.3	No	No	0	5	7
279	R:R:R125	R:R:T123	1.29	No	No	0	4	8
280	R:R:L114	R:R:R117	1.21	Yes	No	0	5	5
281	R:R:L294	R:R:Y284	1.17	No	No	10	4	5
282	R:R:L294	R:R:Y293	1.17	No	No	10	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y15	11.542	5	1	4
2	R:R:E19	8.315	4	1	5
3	R:R:L43	6.5425	4	4	8
4	R:R:F48	6.2475	4	0	9
5	R:R:L54	5.6475	4	2	9
6	R:R:D58	7.175	4	2	9
7	R:R:M66	4.14	5	0	6
8	R:R:F80	7.334	5	8	3
9	R:R:T87	4.7225	4	1	4
10	R:R:M90	5.76	4	0	6
11	R:R:L91	6.265	4	1	4
12	R:R:I92	5.99	4	0	5
13	R:R:F93	8.018	5	0	6
14	R:R:H95	5.474	5	1	6
15	R:R:R111	11.0725	4	3	8
16	R:R:L114	3.3375	4	0	5
17	R:R:Y118	8.64667	6	3	8
18	R:R:P145	6.675	4	1	5
19	R:R:M146	3.83	4	0	5
20	R:R:N150	5.1825	4	8	5
21	R:R:F168	11.885	4	1	5
22	R:R:M172	5.686	5	1	4
23	R:R:Y176	9.104	5	1	6
24	R:R:F182	8.0075	4	0	5
25	R:R:W185	7.48167	6	1	5
26	R:R:Y197	6.73	6	2	9
27	R:R:F239	8.47	4	2	8
28	R:R:W243	9.254	5	2	8
29	R:R:Y254	9.045	4	0	4
30	R:R:V259	3.5875	4	9	4
31	R:R:Y265	13.385	4	0	4
32	R:R:I268	8.495	4	1	5
33	R:R:H272	8.37	4	1	7
34	R:R:N274	7.8775	4	2	9
35	R:R:N278	8.5275	4	2	9
36	R:R:Y282	7.166	5	2	9
37	R:R:T292	7.075	4	4	7
38	L:L:?1	11.72	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I268	R:R:Y15	19.6026	12.09	Yes	Yes	1	5	4
2	R:R:G23	R:R:M66	11.7481	1.75	No	Yes	0	6	6
3	R:R:A26	R:R:G23	14.1817	1.95	No	No	0	7	6
4	R:R:A26	R:R:S275	15.427	3.42	No	No	0	7	9
5	R:R:D58	R:R:S275	19.1427	4.42	Yes	No	0	9	9
6	R:R:D58	R:R:N278	19.861	6.73	Yes	Yes	2	9	9
7	R:R:N274	R:R:N278	95.1967	10.9	Yes	Yes	2	9	9
8	R:R:N274	R:R:W243	91.1889	7.91	Yes	Yes	2	9	8
9	R:R:T94	R:R:W243	99.7013	3.64	No	Yes	0	6	8
10	R:R:H95	R:R:T94	100	4.11	Yes	No	0	6	6
11	R:R:H95	R:R:L91	95.3377	5.14	Yes	Yes	1	6	4
12	R:R:L91	R:R:M172	51.7555	4.24	Yes	Yes	1	4	4
13	R:R:F168	R:R:M172	35.1168	7.46	Yes	Yes	1	5	4
14	L:L:?1	R:R:F168	41.2225	26.18	Yes	Yes	1	0	5
15	R:R:L91	R:R:Y176	37.9062	10.55	Yes	Yes	1	4	6
16	R:R:M177	R:R:Y176	38.6647	5.99	No	Yes	1	5	6
17	L:L:?1	R:R:M177	38.319	5.52	Yes	No	1	0	5
18	L:L:?1	R:R:I268	30.1121	11.16	Yes	Yes	1	0	5
19	R:R:L269	R:R:V18	22.4926	11.92	No	No	0	5	4
20	R:R:E19	R:R:H272	10.5632	16	Yes	Yes	1	5	7
21	R:R:I22	R:R:V18	15.0208	3.07	No	No	0	7	4
22	R:R:F289	R:R:V36	10.7411	13.11	No	No	0	8	8
23	R:R:T292	R:R:V36	16.4306	4.76	Yes	No	0	7	8
24	R:R:L43	R:R:T292	20.5693	4.42	Yes	Yes	4	8	7
25	R:R:F48	R:R:L43	26.2017	13.4	Yes	Yes	0	9	8
26	R:R:F48	R:R:T47	29.424	6.49	Yes	No	0	9	8
27	R:R:R111	R:R:T47	30.4679	6.47	Yes	No	0	8	8
28	R:R:D107	R:R:R111	34.4589	13.1	No	Yes	3	9	8
29	R:R:D107	R:R:F50	62.4597	11.94	No	No	0	9	8
30	R:R:F50	R:R:L131	64.1716	4.87	No	No	0	8	7
31	R:R:L131	R:R:S53	65.8365	6.01	No	No	0	7	9
32	R:R:S100	R:R:S53	66.6588	3.26	No	No	0	7	9
33	R:R:L54	R:R:S100	67.4745	6.01	Yes	No	0	9	7
34	R:R:L54	R:R:N278	56.0889	6.87	Yes	Yes	2	9	9
35	R:R:D107	R:R:Y118	27.2355	5.75	No	Yes	3	9	8
36	R:R:I104	R:R:L54	13.3123	4.28	No	Yes	2	8	9
37	R:R:T87	R:R:V171	15.4706	4.76	Yes	No	0	4	5
38	R:R:F80	R:R:V171	10.335	7.87	Yes	No	0	3	5
39	R:R:L101	R:R:N278	22.9592	9.61	No	Yes	0	8	9
40	R:R:L101	R:R:Y282	21.9019	7.03	No	Yes	0	8	9
41	R:R:L102	R:R:V106	13.1747	2.98	No	No	0	7	6
42	R:R:L110	R:R:V106	14.3092	2.98	No	No	0	5	6
43	R:R:L110	R:R:L114	15.4672	4.15	No	Yes	0	5	5
44	R:R:L114	R:R:Y118	21.1399	3.52	Yes	Yes	0	5	8
45	R:R:L102	R:R:V192	12.0435	7.45	No	No	0	7	6
46	R:R:Y197	R:R:Y282	16.4642	3.97	Yes	Yes	2	9	9
47	R:R:I196	R:R:V192	10.8687	3.07	No	No	0	6	6
48	R:R:M174	R:R:N250	25.4733	5.61	No	No	0	3	5
49	L:L:?1	R:R:N250	26.6615	14.31	Yes	No	0	0	5
50	R:R:M174	R:R:R169	13.7419	8.69	No	No	0	3	4
51	R:R:L253	R:R:R169	12.4698	4.86	No	No	0	4	4
52	R:R:M174	R:R:Y254	10.9694	5.99	No	Yes	0	3	4
53	R:R:L232	R:R:Y197	13.6815	15.24	No	Yes	0	8	9
54	R:R:V235	R:R:Y282	10.7311	12.62	No	Yes	2	8	9
55	R:R:L232	R:R:T228	12.302	2.95	No	No	0	8	7
56	R:R:V235	R:R:V281	10.0396	1.6	No	No	0	8	8
57	R:R:L253	R:R:V259	11.1137	4.47	No	Yes	0	4	4
58	L:L:?1	R:R:H272	11.8589	6.7	Yes	Yes	1	0	7
59	R:R:E19	R:R:L269	17.4543	5.3	Yes	No	1	5	5
60	R:R:M172	R:R:T87	15.4505	4.52	Yes	Yes	1	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E19	R:R:Y15	7.86	1	Yes	Yes	5	4	2	2
R:R:I268	R:R:Y15	12.09	1	Yes	Yes	5	4	1	2
R:R:E19	R:R:I268	4.1	1	Yes	Yes	5	5	2	1
R:R:E19	R:R:H272	16	1	Yes	Yes	5	7	2	1
R:R:M90	R:R:V65	9.13	0	Yes	No	6	7	1	2
R:R:H272	R:R:V65	4.15	1	Yes	No	7	7	1	2
R:R:L68	R:R:M90	4.24	0	No	Yes	5	6	2	1
R:R:F168	R:R:T87	5.19	1	Yes	Yes	5	4	1	2
R:R:M172	R:R:T87	4.52	1	Yes	Yes	4	4	2	2
L:L:?1	R:R:M90	6.45	1	Yes	Yes	0	6	0	1
R:R:F168	R:R:M172	7.46	1	Yes	Yes	5	4	1	2
R:R:F168	R:R:M177	8.71	1	Yes	No	5	5	1	1
L:L:?1	R:R:F168	26.18	1	Yes	Yes	0	5	0	1
R:R:M172	R:R:Y176	7.18	1	Yes	Yes	4	6	2	2
R:R:M174	R:R:N250	5.61	0	No	No	3	5	2	1
R:R:M177	R:R:Y176	5.99	1	No	Yes	5	6	1	2
L:L:?1	R:R:M177	5.52	1	Yes	No	0	5	0	1
R:R:G267	R:R:L246	3.42	0	No	No	6	6	2	1
L:L:?1	R:R:L246	13.52	1	Yes	No	0	6	0	1
L:L:?1	R:R:N250	14.31	1	Yes	No	0	5	0	1
R:R:L264	R:R:Q261	9.32	0	No	No	4	2	1	2
L:L:?1	R:R:L264	9.92	1	Yes	No	0	4	0	1
R:R:H272	R:R:I268	6.63	1	Yes	Yes	7	5	1	1
L:L:?1	R:R:I268	11.16	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:H272	6.7	1	Yes	Yes	0	7	0	1
R:R:A69	R:R:M90	3.22	0	No	Yes	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YH3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.26
Number of Linked Nodes	250
Number of Links	282
Number of Hubs	38
Number of Links mediated by Hubs	137
Number of Communities	10
Number of Nodes involved in Communities	54
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	49871
Length Of Smallest Path	3
Average Path Length	16.0263
Length of Longest Path	36
Minimum Path Strength	1.505
Average Path Strength	6.86067
Maximum Path Strength	22.985
Minimum Path Correlation	0.7
Average Path Correlation	0.926881
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	44.6629
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.9131
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • synapse • cell junction • intracellular anatomical structure • cytoplasm • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled adenosine receptor activity • identical protein binding • protein binding • binding • host cell surface binding • host cell surface receptor binding • bioluminescence • metabolic process • cellular process • generation of precursor metabolites and energy • viral process • fusion of virus membrane with host endosome membrane • membrane fusion involved in viral entry into host cell • membrane organization • cellular component organization • membrane fusion • fusion of virus membrane with host plasma membrane • cellular component organization or biogenesis • virion attachment to host cell • biological process involved in interspecies interaction between organisms • adhesion of symbiont to host cell • viral life cycle • adhesion of symbiont to host • biological process involved in interaction with host • biological process involved in symbiotic interaction • non-lytic viral release • viral budding • virion assembly • exit from host cell • viral budding from plasma membrane • viral release from host cell • import into cell • receptor-mediated endocytosis of virus by host cell • transport • establishment of localization • vesicle-mediated transport • localization • symbiont entry into host cell • clathrin-dependent endocytosis • symbiont entry into host • clathrin-dependent endocytosis of virus by host cell • receptor-mediated endocytosis • endocytosis • endocytosis involved in viral entry into host cell • somatodendritic compartment • dendrite • dendritic tree • virion component • virion membrane • viral membrane • viral envelope • host cell plasma membrane • host cellular component • host cell part • host cell membrane • cation binding • magnesium ion binding • ion binding • metal ion binding • small molecule binding • guanyl nucleotide binding • nucleotide binding • GDP binding • guanyl ribonucleotide binding • purine ribonucleotide binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • G protein-coupled serotonin receptor binding • signaling receptor binding • G protein-coupled receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • GTP binding • purine ribonucleoside triphosphate binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • G-protein beta-subunit binding • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of cellular process • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of biological process • regulation of cell cycle process • biological regulation • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of biological process • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • positive regulation of cellular process • cell division • cellular response to stimulus • response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to lipid • response to alcohol • cellular response to forskolin • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to chemical • response to forskolin • cellular response to lipid • cellular response to ketone • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • response to prostaglandin • response to endogenous stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • response to hormone • response to prostaglandin E • cellular response to hormone stimulus • midbody • cell cortex • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • intracellular membrane-bounded organelle • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle
SCOP2	Domain Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	6MD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	6MD
Name	N-methyladenosine
Synonyms
Identifier
Formula	C11 H15 N5 O4
Molecular Weight	281.268
SMILES
PubChem	102175
Formal Charge	0
Total Atoms	35
Total Chiral Atoms	4
Total Bonds	37
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P0DMS8
Sequence	>8YH3_nogp_Chain_R S V T Y I T E I I G L C A I V G N V L V I V V K L N P S L Q T T T F Y F I V S L A L A D I A V G V L V M P L A I V S L G T I H F Y S C L F M T C L L I F T H A S I M S L L A I A V D R Y L R V K L T V R Y R V T T R R I W L A L G L C W L V S F L V G L T P M F G W N M K L S N T F L C F S V M R M D Y M V Y F S F W I P L V V M C A I Y D I F Y I I R N L E F K T A K S L L V L F L F A L W L P L S I I N C I Y F G V P Q V L Y G I L L S H A N S M M N P I V Y A Y K I K K F K E T Y L L I W T S V L W I V M R Q S A D E L P R R F L L V F R L C L D Q T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YH6	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-	Gi1/β1/γ2	3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-		3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH0	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-	Gi1/β1/γ2	2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH0 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-		2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8X17	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.19	2024-04-24	10.1038/s41467-024-47207-6
	8X17 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.19	2024-04-24	10.1038/s41467-024-47207-6
	8X16	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	Gi1/β1/γ2	3.29	2024-04-24	10.1038/s41467-024-47207-6
	8X16 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.29	2024-04-24	10.1038/s41467-024-47207-6

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