psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S9	R:R:T11	6.4	No	Yes	5	4	4
2	R:R:Q261	R:R:S9	5.78	No	No	5	2	4
3	R:R:Q261	R:R:T11	9.92	No	Yes	5	2	4
4	R:R:T11	R:R:T262	4.71	Yes	No	0	4	2
5	R:R:T11	R:R:Y265	7.49	Yes	Yes	5	4	4
6	R:R:S12	R:R:Y265	5.09	No	Yes	0	3	4
7	R:R:Y15	R:R:Y265	28.79	No	Yes	0	4	4
8	R:R:I268	R:R:Y15	13.3	Yes	No	0	5	4
9	R:R:L269	R:R:Y15	5.86	No	No	0	5	4
10	R:R:L269	R:R:V18	11.92	No	No	0	5	4
11	R:R:E19	R:R:M66	5.41	No	Yes	0	5	6
12	R:R:A69	R:R:E19	4.53	No	No	0	6	5
13	R:R:E19	R:R:H272	17.23	No	Yes	0	5	7
14	R:R:I20	R:R:M66	4.37	No	Yes	0	4	6
15	R:R:A273	R:R:I22	4.87	No	No	0	6	7
16	R:R:C25	R:R:M276	6.48	No	No	0	5	6
17	R:R:I27	R:R:I59	4.42	Yes	Yes	6	6	7
18	R:R:G29	R:R:V28	3.68	No	No	0	8	4
19	R:R:D58	R:R:N30	6.73	Yes	No	0	9	9
20	R:R:N30	R:R:P279	8.15	No	No	0	9	9
21	R:R:K38	R:R:W35	8.12	No	No	8	1	4
22	R:R:L39	R:R:W35	15.94	No	No	8	5	4
23	R:R:F289	R:R:V36	11.8	No	No	0	8	8
24	R:R:Q44	R:R:V37	4.3	No	No	0	7	8
25	R:R:K38	R:R:L39	4.23	No	No	8	1	5
26	R:R:N40	R:R:S42	5.96	Yes	No	0	5	5
27	R:R:L43	R:R:N40	13.73	No	Yes	9	8	5
28	R:R:N40	R:R:T292	4.39	Yes	No	9	5	7
29	R:R:F48	R:R:L43	12.18	Yes	No	0	9	8
30	R:R:L43	R:R:T292	4.42	No	No	9	8	7
31	R:R:R111	R:R:T46	3.88	Yes	Yes	7	8	5
32	R:R:T46	R:R:Y118	6.24	Yes	Yes	7	5	8
33	R:R:R119	R:R:T46	3.88	No	Yes	0	4	5
34	R:R:F48	R:R:T47	6.49	Yes	No	0	9	8
35	R:R:R111	R:R:T47	3.88	Yes	No	0	8	8
36	R:R:F48	R:R:I51	3.77	Yes	No	0	9	8
37	R:R:F48	R:R:I286	3.77	Yes	No	0	9	8
38	R:R:Q124	R:R:Y49	10.15	No	No	10	3	4
39	R:R:I127	R:R:Y49	7.25	No	No	0	6	4
40	R:R:W128	R:R:Y49	4.82	No	No	10	1	4
41	R:R:F50	R:R:I104	3.77	No	Yes	0	8	8
42	R:R:D107	R:R:F50	15.52	No	No	0	9	8
43	R:R:L131	R:R:S53	9.01	No	No	0	7	9
44	R:R:L54	R:R:S100	7.51	No	No	0	9	7
45	R:R:I104	R:R:L54	4.28	Yes	No	0	8	9
46	R:R:L54	R:R:N278	8.24	No	Yes	0	9	9
47	R:R:D58	R:R:S97	8.83	Yes	No	0	9	9
48	R:R:D58	R:R:S275	5.89	Yes	No	0	9	9
49	R:R:D58	R:R:N278	8.08	Yes	Yes	0	9	9
50	R:R:A60	R:R:F93	9.71	No	Yes	0	6	6
51	R:R:S275	R:R:V61	4.85	No	No	0	9	8
52	R:R:L64	R:R:L89	4.15	No	No	11	4	5
53	R:R:F93	R:R:L64	3.65	Yes	No	11	6	4
54	R:R:M90	R:R:V65	7.61	No	No	0	6	7
55	R:R:H272	R:R:V65	4.15	Yes	No	0	7	7
56	R:R:M66	R:R:P67	10.06	Yes	No	0	6	8
57	R:R:L68	R:R:M86	8.48	No	No	0	5	6
58	R:R:L68	R:R:L89	5.54	No	No	0	5	5
59	R:R:L68	R:R:M90	8.48	No	No	0	5	6
60	R:R:L74	R:R:S73	4.5	No	No	0	4	5
61	R:R:I78	R:R:V76	6.14	No	No	0	5	2
62	R:R:P165	R:R:T77	5.25	No	No	0	5	3
63	R:R:H79	R:R:Y81	4.36	Yes	No	0	7	1
64	R:R:H79	R:R:S82	6.97	Yes	No	0	7	5
65	R:R:H79	R:R:T162	4.11	Yes	No	0	7	3
66	R:R:F163	R:R:H79	6.79	No	Yes	0	2	7
67	R:R:F80	R:R:Y81	11.35	Yes	No	0	3	1
68	R:R:F80	R:R:L84	15.83	Yes	No	0	3	6
69	R:R:F80	R:R:N150	4.83	Yes	No	0	3	5
70	R:R:F80	R:R:K152	18.61	Yes	No	0	3	4
71	R:R:F80	R:R:V171	6.55	Yes	No	0	3	5
72	R:R:C166	R:R:C83	7.28	No	No	0	9	9
73	R:R:L84	R:R:T87	4.42	No	No	0	6	4
74	R:R:L84	R:R:M146	7.07	No	No	0	6	5
75	R:R:F85	R:R:M86	3.73	No	No	0	5	6
76	R:R:F168	R:R:T87	5.19	No	No	0	5	4
77	R:R:C88	R:R:P145	5.65	No	Yes	0	6	5
78	R:R:F93	R:R:L89	4.87	Yes	No	11	6	5
79	L:L:?1	R:R:M90	4.39	Yes	No	0	0	6
80	R:R:L91	R:R:M177	4.24	No	Yes	0	4	5
81	R:R:F139	R:R:I92	10.05	No	No	0	4	5
82	R:R:H95	R:R:T94	4.11	Yes	No	0	6	6
83	R:R:T94	R:R:W243	4.85	No	Yes	0	6	8
84	R:R:H95	R:R:S181	5.58	Yes	No	0	6	5
85	R:R:H95	R:R:W185	5.29	Yes	Yes	0	6	5
86	R:R:H95	R:R:I186	5.3	Yes	No	0	6	7
87	R:R:A96	R:R:W135	7.78	No	No	0	7	9
88	R:R:F239	R:R:I98	3.77	Yes	No	2	8	8
89	R:R:I98	R:R:W243	11.74	No	Yes	2	8	8
90	R:R:C134	R:R:M99	4.86	No	No	0	7	5
91	R:R:L101	R:R:N278	6.87	No	Yes	0	8	9
92	R:R:L101	R:R:Y282	4.69	No	Yes	0	8	9
93	R:R:L102	R:R:V192	5.96	No	No	0	7	6
94	R:R:I104	R:R:R108	6.26	Yes	No	4	8	9
95	R:R:I104	R:R:Y282	3.63	Yes	Yes	4	8	9
96	R:R:A105	R:R:M193	4.83	No	No	0	8	8
97	R:R:A105	R:R:Y197	4	No	Yes	0	8	9
98	R:R:D107	R:R:R111	8.34	No	Yes	7	9	8
99	R:R:D107	R:R:Y118	5.75	No	Yes	7	9	8
100	R:R:R108	R:R:Y197	7.2	No	Yes	4	9	9
101	R:R:R108	R:R:Y282	8.23	No	Yes	4	9	9
102	R:R:K113	R:R:Y109	16.72	No	No	0	6	8
103	R:R:I196	R:R:Y109	8.46	No	No	0	6	8
104	R:R:I200	R:R:Y109	4.84	No	No	0	9	8
105	R:R:L110	R:R:L114	5.54	No	No	0	5	5
106	R:R:R111	R:R:Y118	21.61	Yes	Yes	7	8	8
107	R:R:L114	R:R:R117	4.86	No	No	0	5	5
108	R:R:T115	R:R:V116	4.76	No	No	0	8	6
109	R:R:T122	R:R:Y118	13.73	No	Yes	0	6	8
110	R:R:R126	R:R:T123	5.17	No	No	0	5	8
111	R:R:Q124	R:R:W128	9.86	No	No	10	3	1
112	R:R:V137	R:R:W185	4.9	No	Yes	0	4	5
113	R:R:G142	R:R:V141	3.68	No	Yes	0	7	4
114	R:R:F180	R:R:V141	6.55	No	Yes	1	5	4
115	R:R:V141	R:R:W185	13.48	Yes	Yes	1	4	5
116	R:R:M172	R:R:P145	5.03	No	Yes	1	4	5
117	R:R:P145	R:R:Y176	8.34	Yes	Yes	1	5	6
118	R:R:M151	R:R:S155	6.13	No	No	0	4	3
119	R:R:M151	R:R:R173	4.96	No	No	0	4	4
120	R:R:K152	R:R:L161	8.46	No	No	0	4	3
121	R:R:R173	R:R:S154	6.59	No	No	0	4	2
122	R:R:D158	R:R:L161	12.21	No	No	0	2	3
123	R:R:N160	R:R:T162	4.39	No	No	0	4	3
124	R:R:L161	R:R:L164	6.92	No	No	0	3	4
125	R:R:R167	R:R:S170	3.95	No	No	0	5	4
126	R:R:F168	R:R:M177	4.98	No	Yes	0	5	5
127	L:L:?1	R:R:F168	31.8	Yes	No	0	0	5
128	R:R:M174	R:R:R169	7.44	No	No	0	3	4
129	R:R:M172	R:R:Y176	9.58	No	Yes	1	4	6
130	R:R:M172	R:R:M177	4.33	No	Yes	1	4	5
131	R:R:D175	R:R:R173	16.68	No	No	0	4	4
132	R:R:M174	R:R:Y254	3.59	No	Yes	0	3	4
133	L:L:?1	R:R:M174	6.15	Yes	No	0	0	3
134	R:R:M177	R:R:Y176	3.59	Yes	Yes	1	5	6
135	R:R:F180	R:R:Y176	9.28	No	Yes	1	5	6
136	R:R:Y179	R:R:Y254	10.92	No	Yes	0	3	4
137	R:R:F180	R:R:W185	7.02	No	Yes	1	5	5
138	R:R:F182	R:R:I186	3.77	Yes	No	0	5	7
139	R:R:F182	R:R:L187	3.65	Yes	No	0	5	4
140	R:R:F182	R:R:S247	18.5	Yes	No	0	5	6
141	R:R:L184	R:R:W185	14.81	No	Yes	0	3	5
142	R:R:F239	R:R:L190	7.31	Yes	No	2	8	6
143	R:R:L190	R:R:L244	4.15	No	No	2	6	6
144	R:R:F239	R:R:M193	7.46	Yes	No	0	8	8
145	R:R:I196	R:R:Y197	3.63	No	Yes	0	6	9
146	R:R:L232	R:R:Y197	17.58	No	Yes	0	8	9
147	R:R:V235	R:R:Y197	7.57	No	Yes	4	8	9
148	R:R:L236	R:R:Y197	7.03	No	Yes	0	7	9
149	R:R:Y197	R:R:Y282	4.96	Yes	Yes	4	9	9
150	R:R:D199	R:R:I203	5.6	No	No	0	4	5
151	R:R:A229	R:R:F201	5.55	No	No	0	7	5
152	R:R:I203	R:R:Y202	7.25	No	No	0	5	3
153	R:R:I204	R:R:T228	6.08	No	No	0	8	7
154	R:R:E225	R:R:R205	8.14	No	No	0	7	5
155	R:R:E225	R:R:F226	7	No	No	0	7	4
156	R:R:K285	R:R:S231	6.12	No	No	0	7	8
157	R:R:L234	R:R:L238	5.54	No	Yes	12	6	6
158	R:R:L234	R:R:V281	7.45	No	No	12	6	8
159	R:R:V235	R:R:Y282	11.36	No	Yes	4	8	9
160	R:R:F237	R:R:L238	3.65	No	Yes	0	4	6
161	R:R:L238	R:R:M277	4.24	Yes	No	0	6	6
162	R:R:L238	R:R:V281	4.47	Yes	No	12	6	8
163	R:R:F239	R:R:W243	6.01	Yes	Yes	2	8	8
164	R:R:C242	R:R:N274	7.87	No	No	0	8	9
165	R:R:S271	R:R:W243	11.12	No	Yes	0	7	8
166	R:R:L246	R:R:N250	4.12	Yes	No	3	6	5
167	R:R:G267	R:R:L246	5.13	No	Yes	0	6	6
168	R:R:I268	R:R:L246	5.71	Yes	Yes	3	5	6
169	L:L:?1	R:R:L246	5.16	Yes	Yes	3	0	6
170	L:L:?1	R:R:N250	16.22	Yes	No	3	0	5
171	R:R:L253	R:R:V259	8.94	No	Yes	0	4	4
172	L:L:?1	R:R:L253	4.3	Yes	No	0	0	4
173	R:R:F255	R:R:Y254	12.38	No	Yes	0	4	4
174	R:R:P260	R:R:V263	10.6	No	No	0	4	4
175	R:R:Q261	R:R:Y265	14.65	No	Yes	5	2	4
176	L:L:?1	R:R:L264	7.74	Yes	No	0	0	4
177	R:R:H272	R:R:I268	5.3	Yes	Yes	3	7	5
178	L:L:?1	R:R:I268	14.19	Yes	Yes	3	0	5
179	L:L:?1	R:R:H272	10.39	Yes	Yes	3	0	7
180	R:R:M277	R:R:N274	5.61	No	No	0	6	9
181	R:R:N274	R:R:N278	5.45	No	Yes	0	9	9
182	R:R:A283	R:R:F289	6.93	No	No	0	7	8
183	R:R:K290	R:R:Y284	4.78	No	Yes	0	8	5
184	R:R:Y284	R:R:Y293	7.94	Yes	No	0	5	7
185	R:R:I286	R:R:K288	4.36	No	No	0	8	6
186	R:R:F289	R:R:Y293	5.16	No	No	0	8	7
187	R:R:P279	R:R:V33	3.53	No	No	0	9	9
188	R:R:P189	R:R:V188	3.53	No	No	0	8	4
189	R:R:P260	R:R:V259	3.53	No	Yes	0	4	4
190	R:R:L32	R:R:Y293	3.52	No	No	0	6	7
191	R:R:I296	R:R:W35	3.52	No	No	0	5	4
192	R:R:P145	R:R:T144	3.5	Yes	No	0	5	5
193	R:R:G23	R:R:M66	3.49	No	Yes	0	6	6
194	R:R:D175	R:R:Y254	3.45	No	Yes	0	4	4
195	R:R:A26	R:R:S275	3.42	No	No	0	7	9
196	R:R:A57	R:R:S97	3.42	No	No	0	8	9
197	R:R:A96	R:R:S138	3.42	No	No	0	7	8
198	R:R:G267	R:R:L266	3.42	No	No	0	6	4
199	R:R:A283	R:R:V33	3.39	No	No	0	7	9
200	R:R:I98	R:R:P189	3.39	No	No	0	8	8
201	R:R:L270	R:R:P245	3.28	No	No	0	7	9
202	R:R:N40	R:R:P41	3.26	Yes	No	0	5	6
203	R:R:A55	R:R:I34	3.25	No	No	0	9	7
204	R:R:R117	R:R:R120	3.2	No	No	0	5	5
205	R:R:C194	R:R:L236	3.17	No	No	0	4	7
206	R:R:A240	R:R:L190	3.15	No	No	2	6	6
207	R:R:A240	R:R:L244	3.15	No	No	2	6	6
208	R:R:T45	R:R:T47	3.14	No	No	0	7	8
209	R:R:I16	R:R:S73	3.1	No	No	0	5	5
210	R:R:I27	R:R:V63	3.07	Yes	No	6	6	4
211	R:R:I34	R:R:V52	3.07	No	No	0	7	5
212	R:R:I59	R:R:V63	3.07	Yes	No	6	7	4
213	R:R:M99	R:R:S138	3.07	No	No	0	5	8
214	R:R:I203	R:R:V112	3.07	No	No	0	5	9
215	R:R:I249	R:R:V259	3.07	No	Yes	0	5	4
216	R:R:I249	R:R:V263	3.07	No	No	0	5	4
217	R:R:I252	R:R:V259	3.07	No	Yes	0	4	4
218	R:R:I127	R:R:T46	3.04	No	Yes	0	6	5
219	R:R:I127	R:R:T122	3.04	No	No	0	6	6
220	R:R:L102	R:R:V106	2.98	No	No	0	7	6
221	R:R:L232	R:R:T228	2.95	No	No	0	8	7
222	R:R:I70	R:R:M66	2.92	No	Yes	0	6	6
223	R:R:I22	R:R:L269	2.85	No	No	0	7	5
224	R:R:I92	R:R:L143	2.85	No	No	0	5	4
225	R:R:H95	R:R:S138	2.79	Yes	No	0	6	8
226	R:R:C251	R:R:F255	2.79	No	No	0	5	4
227	R:R:A103	R:R:F50	2.77	No	No	0	6	8
228	R:R:L266	R:R:L270	2.77	No	No	0	4	7
229	R:R:E291	R:R:K288	2.7	No	No	0	5	6
230	R:R:E291	R:R:L295	2.65	No	No	0	5	4
231	R:R:F201	R:R:T228	2.59	No	No	0	5	7
232	R:R:V178	R:R:Y254	2.52	No	Yes	0	5	4
233	R:R:F93	R:R:I92	2.51	Yes	No	0	6	5
234	R:R:F182	R:R:I248	2.51	Yes	No	0	5	5
235	R:R:F147	R:R:M146	2.49	No	No	0	5	5
236	R:R:F237	R:R:L241	2.44	No	No	0	4	5
237	R:R:I280	R:R:Y284	2.42	No	Yes	0	6	5
238	R:R:L110	R:R:Y118	2.34	No	Yes	0	5	8
239	R:R:R167	R:R:R169	2.13	No	No	0	5	4
240	R:R:G23	R:R:G62	2.11	No	No	0	6	6
241	L:L:?1	R:R:I72	1.77	Yes	No	0	0	5
242	R:R:G62	R:R:I27	1.76	No	Yes	0	6	6
243	R:R:G132	R:R:L131	1.71	No	No	0	4	7
244	R:R:C166	R:R:V171	1.71	No	No	0	9	5
245	R:R:A55	R:R:V33	1.7	No	No	0	9	9
246	R:R:L164	R:R:P165	1.64	No	No	0	4	5
247	R:R:S100	R:R:S53	1.63	No	No	0	7	9
248	R:R:A26	R:R:M276	1.61	No	No	0	7	6
249	R:R:T17	R:R:V13	1.59	No	No	0	6	3
250	R:R:T14	R:R:V18	1.59	No	No	0	4	4
251	R:R:T77	R:R:V76	1.59	No	No	0	3	2
252	R:R:P41	R:R:Q44	1.58	No	No	0	6	7
253	R:R:I27	R:R:V31	1.54	Yes	No	6	6	4
254	R:R:I59	R:R:V31	1.54	Yes	No	6	7	4
255	R:R:I200	R:R:V112	1.54	No	No	0	9	9
256	R:R:I196	R:R:V192	1.54	No	No	0	6	6
257	R:R:L32	R:R:V28	1.49	No	No	0	6	4
258	R:R:L133	R:R:V137	1.49	No	No	0	3	4
259	R:R:L140	R:R:V141	1.49	No	Yes	0	4	4
260	R:R:L187	R:R:V191	1.49	No	No	0	4	4
261	R:R:I16	R:R:I70	1.47	No	No	0	5	6
262	R:R:L21	R:R:T17	1.47	No	No	0	4	6
263	R:R:I20	R:R:L21	1.43	No	No	0	4	4
264	R:R:I20	R:R:L24	1.43	No	No	0	4	4
265	R:R:I59	R:R:L56	1.43	Yes	No	0	7	6
266	R:R:I204	R:R:L208	1.43	No	No	0	8	4
267	R:R:Q258	R:R:V259	1.43	No	Yes	0	2	4
268	R:R:K285	R:R:L234	1.41	No	No	0	7	6
269	R:R:L233	R:R:L236	1.38	No	No	0	5	7
270	R:R:L153	R:R:N150	1.37	No	No	0	3	5
271	R:R:E225	R:R:L208	1.33	No	No	0	7	4
272	R:R:R117	R:R:V116	1.31	No	No	0	5	6
273	R:R:R125	R:R:T123	1.29	No	No	0	4	8
274	R:R:F183	R:R:L187	1.22	No	No	0	4	4
275	R:R:L294	R:R:Y284	1.17	No	Yes	0	4	5
276	R:R:N206	R:R:Y202	1.16	No	No	0	4	3
277	R:R:L153	R:R:W149	1.14	No	No	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T11	7.13	4	5	4
2	R:R:I27	2.6975	4	6	6
3	R:R:N40	6.835	4	9	5
4	R:R:T46	4.26	4	7	5
5	R:R:F48	6.5525	4	0	9
6	R:R:D58	7.3825	4	0	9
7	R:R:I59	2.615	4	6	7
8	R:R:M66	5.25	5	0	6
9	R:R:H79	5.5575	4	0	7
10	R:R:F80	11.434	5	0	3
11	R:R:F93	5.185	4	11	6
12	R:R:H95	4.614	5	0	6
13	R:R:I104	4.485	4	4	8
14	R:R:R111	9.4275	4	7	8
15	R:R:Y118	9.934	5	7	8
16	R:R:V141	6.3	4	1	4
17	R:R:P145	5.63	4	1	5
18	R:R:Y176	7.6975	4	1	6
19	R:R:M177	4.285	4	1	5
20	R:R:F182	7.1075	4	0	5
21	R:R:W185	9.1	5	1	5
22	R:R:Y197	7.42429	7	4	9
23	R:R:L238	4.475	4	12	6
24	R:R:F239	6.1375	4	2	8
25	R:R:W243	8.43	4	2	8
26	R:R:L246	5.03	4	3	6
27	R:R:Y254	6.572	5	0	4
28	R:R:V259	4.008	5	0	4
29	R:R:Y265	14.005	4	5	4
30	R:R:I268	9.625	4	3	5
31	R:R:H272	9.2675	4	3	7
32	R:R:N278	7.16	4	0	9
33	R:R:Y282	6.574	5	4	9
34	R:R:Y284	4.0775	4	0	5
35	L:L:?1	10.211	10	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I268	R:R:Y15	16.3948	13.3	Yes	No	0	5	4
2	R:R:E19	R:R:H272	26.2171	17.23	No	Yes	0	5	7
3	R:R:E19	R:R:M66	23.7487	5.41	No	Yes	0	5	6
4	R:R:D58	R:R:N278	25.0555	8.08	Yes	Yes	0	9	9
5	R:R:L101	R:R:N278	26.815	6.87	No	Yes	0	8	9
6	R:R:L101	R:R:Y282	27.5325	4.69	No	Yes	0	8	9
7	R:R:Y197	R:R:Y282	62.5641	4.96	Yes	Yes	4	9	9
8	R:R:A105	R:R:Y197	100	4	No	Yes	0	8	9
9	R:R:A105	R:R:M193	99.9616	4.83	No	No	0	8	8
10	R:R:F239	R:R:M193	99.8078	7.46	Yes	No	0	8	8
11	R:R:F239	R:R:W243	97.301	6.01	Yes	Yes	2	8	8
12	R:R:T94	R:R:W243	98.7402	4.85	No	Yes	0	6	8
13	R:R:H95	R:R:T94	98.5694	4.11	Yes	No	0	6	6
14	R:R:H95	R:R:W185	95.281	5.29	Yes	Yes	0	6	5
15	R:R:F180	R:R:W185	91.5613	7.02	No	Yes	1	5	5
16	R:R:F180	R:R:Y176	92.5735	9.28	No	Yes	1	5	6
17	R:R:M177	R:R:Y176	90.2204	3.59	Yes	Yes	1	5	6
18	R:R:F168	R:R:M177	90.9506	4.98	No	Yes	0	5	5
19	L:L:?1	R:R:F168	77.2463	31.8	Yes	No	0	0	5
20	L:L:?1	R:R:I268	15.9421	14.19	Yes	Yes	3	0	5
21	R:R:A283	R:R:F289	10.5526	6.93	No	No	0	7	8
22	R:R:A283	R:R:V33	11.5818	3.39	No	No	0	7	9
23	R:R:P279	R:R:V33	15.6175	3.53	No	No	0	9	9
24	R:R:N30	R:R:P279	16.5998	8.15	No	No	0	9	9
25	R:R:D58	R:R:N30	17.5735	6.73	Yes	No	0	9	9
26	R:R:F48	R:R:L43	12.1498	12.18	Yes	No	0	9	8
27	R:R:F48	R:R:T47	22.2156	6.49	Yes	No	0	9	8
28	R:R:R111	R:R:T47	25.5594	3.88	Yes	No	0	8	8
29	R:R:D107	R:R:R111	36.1121	8.34	No	Yes	7	9	8
30	R:R:D107	R:R:F50	66.9072	15.52	No	No	0	9	8
31	R:R:F50	R:R:I104	69.9265	3.77	No	Yes	0	8	8
32	R:R:I104	R:R:R108	35.48	6.26	Yes	No	4	8	9
33	R:R:R108	R:R:Y197	35.7661	7.2	No	Yes	4	9	9
34	R:R:I104	R:R:Y282	35.5612	3.63	Yes	Yes	4	8	9
35	R:R:R111	R:R:T46	10.1939	3.88	Yes	Yes	7	8	5
36	R:R:D107	R:R:Y118	29.403	5.75	No	Yes	7	9	8
37	R:R:I127	R:R:Y49	15.4339	7.25	No	No	0	6	4
38	R:R:I127	R:R:T46	13.3498	3.04	No	Yes	0	6	5
39	R:R:I104	R:R:L54	14.9385	4.28	Yes	No	0	8	9
40	R:R:L68	R:R:M90	13.5847	8.48	No	No	0	5	6
41	L:L:?1	R:R:M90	14.9257	4.39	Yes	No	0	0	6
42	R:R:F80	R:R:K152	10.1939	18.61	Yes	No	0	3	4
43	R:R:F80	R:R:L84	25.5808	15.83	Yes	No	0	3	6
44	R:R:L84	R:R:T87	28.6684	4.42	No	No	0	6	4
45	R:R:F168	R:R:T87	29.6336	5.19	No	No	0	5	4
46	R:R:I196	R:R:Y197	15.0709	3.63	No	Yes	0	6	9
47	R:R:I196	R:R:Y109	10.1512	8.46	No	No	0	6	8
48	R:R:L110	R:R:Y118	10.732	2.34	No	Yes	0	5	8
49	R:R:M174	R:R:Y254	12.6238	3.59	No	Yes	0	3	4
50	L:L:?1	R:R:M174	17.4453	6.15	Yes	No	0	0	3
51	R:R:L232	R:R:Y197	11.1505	17.58	No	Yes	0	8	9
52	R:R:L232	R:R:T228	10.0871	2.95	No	No	0	8	7
53	R:R:N274	R:R:N278	10.6722	5.45	No	Yes	0	9	9
54	L:L:?1	R:R:H272	25.6876	10.39	Yes	Yes	3	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I268	R:R:Y15	13.3	3	Yes	No	5	4	1	2
R:R:E19	R:R:H272	17.23	0	No	Yes	5	7	2	1
R:R:M90	R:R:V65	7.61	0	No	No	6	7	1	2
R:R:H272	R:R:V65	4.15	3	Yes	No	7	7	1	2
R:R:L68	R:R:M90	8.48	0	No	No	5	6	2	1
R:R:F168	R:R:T87	5.19	0	No	No	5	4	1	2
L:L:?1	R:R:M90	4.39	3	Yes	No	0	6	0	1
R:R:F168	R:R:M177	4.98	0	No	Yes	5	5	1	2
L:L:?1	R:R:F168	31.8	3	Yes	No	0	5	0	1
R:R:M174	R:R:R169	7.44	0	No	No	3	4	1	2
R:R:M174	R:R:Y254	3.59	0	No	Yes	3	4	1	2
L:L:?1	R:R:M174	6.15	3	Yes	No	0	3	0	1
R:R:L246	R:R:N250	4.12	3	Yes	No	6	5	1	1
R:R:G267	R:R:L246	5.13	0	No	Yes	6	6	2	1
R:R:I268	R:R:L246	5.71	3	Yes	Yes	5	6	1	1
L:L:?1	R:R:L246	5.16	3	Yes	Yes	0	6	0	1
L:L:?1	R:R:N250	16.22	3	Yes	No	0	5	0	1
R:R:L253	R:R:V259	8.94	0	No	Yes	4	4	1	2
L:L:?1	R:R:L253	4.3	3	Yes	No	0	4	0	1
L:L:?1	R:R:L264	7.74	3	Yes	No	0	4	0	1
R:R:H272	R:R:I268	5.3	3	Yes	Yes	7	5	1	1
L:L:?1	R:R:I268	14.19	3	Yes	Yes	0	5	0	1
L:L:?1	R:R:H272	10.39	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:I72	1.77	3	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YH5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	254
Number of Links	277
Number of Hubs	35
Number of Links mediated by Hubs	139
Number of Communities	12
Number of Nodes involved in Communities	50
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	41239
Length Of Smallest Path	3
Average Path Length	16.5826
Length of Longest Path	35
Minimum Path Strength	1.255
Average Path Strength	7.03766
Maximum Path Strength	22.995
Minimum Path Correlation	0.7
Average Path Correlation	0.92322
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	37.2217
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.1048
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • synapse • cell junction • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • cation binding • magnesium ion binding • ion binding • metal ion binding • small molecule binding • guanyl nucleotide binding • nucleotide binding • GDP binding • guanyl ribonucleotide binding • purine ribonucleotide binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • G protein-coupled serotonin receptor binding • signaling receptor binding • G protein-coupled receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • GTP binding • purine ribonucleoside triphosphate binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • regulation of protein localization • positive regulation of biological process • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of protein localization to cell cortex • macromolecule localization • positive regulation of protein localization • intracellular protein localization • protein localization to cell cortex • cell division • cellular response to forskolin • response to forskolin • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • midbody • cell cortex • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • intracellular membrane-bounded organelle • identical protein binding • host cell surface binding • host cell surface receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled adenosine receptor activity • bioluminescence • metabolic process • generation of precursor metabolites and energy • viral process • fusion of virus membrane with host endosome membrane • membrane fusion involved in viral entry into host cell • membrane organization • membrane fusion • fusion of virus membrane with host plasma membrane • virion attachment to host cell • biological process involved in interspecies interaction between organisms • adhesion of symbiont to host cell • viral life cycle • adhesion of symbiont to host • biological process involved in interaction with host • biological process involved in symbiotic interaction • non-lytic viral release • viral budding • virion assembly • exit from host cell • viral budding from plasma membrane • viral release from host cell • import into cell • receptor-mediated endocytosis of virus by host cell • transport • establishment of localization • vesicle-mediated transport • symbiont entry into host cell • clathrin-dependent endocytosis • symbiont entry into host • clathrin-dependent endocytosis of virus by host cell • receptor-mediated endocytosis • endocytosis • endocytosis involved in viral entry into host cell • virion component • virion membrane • viral membrane • viral envelope • host cell plasma membrane • host cellular component • host cell part • host cell membrane • other organism part • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ZIR
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ZIR
Name	Riboprine
Synonyms	Riboprine IPA riboprina
Identifier
Formula	C15 H21 N5 O4
Molecular Weight	335.358
SMILES
PubChem	24405
Formal Charge	0
Total Atoms	45
Total Chiral Atoms	4
Total Bonds	47
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P0DMS8
Sequence	>8YH5_nogp_Chain_R S V T Y I T E I I G L C A I V G N V L V I V V K L N P S L Q T T T F Y F I V S L A L A D I A V G V L V M P L A I V S L G T I H F Y S C L F M T C L L I F T H A S I M S L L A I A V D R Y L R V K L T V R Y R V T T R R I W L A L G L C W L V S F L V G L T P M F G W N M K L S N T F L C F S V M R M D Y M V Y F S F W I P L V V M C A I Y D I F Y I I R N L E F K T A K S L L V L F L F A L W L P L S I I N C I Y F G V P Q V L Y G I L L S H A N S M M N P I V Y A Y K I K K F K E T Y L L I W T S V L W I V M R Q S A D E L P R R F L L V F R L C L D Q T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8X16	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	Gi1/β1/γ2	3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X16 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.29	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8X17 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.19	2024-04-24	doi.org/10.1038/s41467-024-47207-6
	8YH0	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-	Gi1/β1/γ2	2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH0 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	NECA	-		2.86	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH2 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.27	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-	Gi1/β1/γ2	3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH5 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Riboprine	-		3.66	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-	Gi1/β1/γ2	3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH6 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Namodenoson	-		3.62	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	9EHS	A	Nucleotide	Adenosine	A_3A	Homo sapiens	LUF7602	-	-	3.2	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-	chim(NtGi1L-Gs-CtGi1)/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBI (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Piclidenoson	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBH	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-	Gi1/β1/γ2	3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x
	9EBH (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	Adenosine	-		3.6	2025-08-20	doi.org/10.1038/s41467-025-62872-x

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