psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D138	21.72	Yes	No	1	0	7
2	L:L:?1	R:R:V139	5.61	Yes	No	0	0	7
3	L:L:?1	R:R:V142	9.82	Yes	No	0	0	6
4	L:L:?1	R:R:F218	4.59	Yes	Yes	1	0	6
5	L:L:?1	R:R:S228	8.48	Yes	No	0	0	6
6	L:L:?1	R:R:S232	5.65	Yes	No	0	0	7
7	L:L:?1	R:R:F340	14.91	Yes	Yes	1	0	7
8	L:L:?1	R:R:F341	10.32	Yes	Yes	1	0	7
9	L:L:?1	R:R:N344	3.88	Yes	No	0	0	6
10	L:L:?1	R:R:N363	12.93	Yes	No	1	0	6
11	R:R:M65	R:R:W364	13.96	No	Yes	0	6	7
12	R:R:L67	R:R:L71	8.3	No	No	0	4	4
13	R:R:I68	R:R:I72	4.42	No	No	0	7	8
14	R:R:I68	R:R:W364	3.52	No	Yes	0	7	7
15	R:R:P113	R:R:V69	3.53	No	No	0	9	6
16	R:R:I72	R:R:S370	6.19	No	No	0	8	9
17	R:R:D104	R:R:N76	20.2	No	No	0	9	9
18	R:R:N76	R:R:P374	8.15	No	No	0	9	9
19	R:R:F387	R:R:L78	9.74	Yes	No	0	7	7
20	R:R:L391	R:R:L78	4.15	No	No	0	6	7
21	R:R:C378	R:R:V79	6.83	No	No	0	8	9
22	R:R:I80	R:R:S102	4.64	No	No	0	7	6
23	R:R:L390	R:R:V81	5.96	No	No	0	5	4
24	R:R:I83	R:R:L89	7.14	Yes	Yes	2	7	8
25	R:R:I83	R:R:N94	5.66	Yes	Yes	2	7	9
26	R:R:F383	R:R:I83	3.77	Yes	Yes	2	8	7
27	R:R:L89	R:R:T86	4.42	Yes	No	0	8	6
28	R:R:D382	R:R:R88	10.72	No	No	0	7	6
29	R:R:D382	R:R:L89	8.14	No	Yes	0	7	8
30	R:R:F383	R:R:L89	7.31	Yes	Yes	2	8	8
31	R:R:N94	R:R:T91	4.39	Yes	No	0	9	7
32	R:R:L170	R:R:L92	4.15	No	No	4	7	6
33	R:R:D155	R:R:T93	4.34	No	No	0	9	8
34	R:R:I97	R:R:N94	5.66	No	Yes	0	8	9
35	R:R:F383	R:R:N94	8.46	Yes	Yes	2	8	9
36	R:R:L95	R:R:V179	4.47	No	No	0	5	7
37	R:R:F96	R:R:V151	7.87	Yes	No	5	8	7
38	R:R:F96	R:R:I152	3.77	Yes	No	0	8	9
39	R:R:D155	R:R:F96	4.78	No	Yes	0	9	8
40	R:R:F96	R:R:L178	7.31	Yes	No	5	8	6
41	R:R:I97	R:R:Y377	3.63	No	Yes	0	8	9
42	R:R:S99	R:R:T148	7.99	No	No	0	9	7
43	R:R:S99	R:R:W183	6.18	No	Yes	0	9	9
44	R:R:L100	R:R:L149	5.54	No	Yes	1	9	8
45	R:R:L100	R:R:N373	15.1	No	No	1	9	9
46	R:R:D104	R:R:S370	10.31	No	No	0	9	9
47	R:R:L105	R:R:L109	4.15	No	No	0	7	5
48	R:R:C141	R:R:V106	5.12	No	No	0	7	7
49	R:R:C141	R:R:M107	8.1	No	No	0	7	7
50	R:R:M107	R:R:Y367	3.59	No	Yes	0	7	8
51	R:R:M107	R:R:S370	7.67	No	No	0	7	9
52	R:R:G108	R:R:V112	3.68	No	No	0	7	7
53	R:R:L110	R:R:V137	8.94	No	No	0	6	5
54	R:R:V111	R:R:W134	9.81	No	Yes	0	7	5
55	R:R:D138	R:R:V111	10.22	No	No	1	7	7
56	R:R:V111	R:R:Y367	5.05	No	Yes	1	7	8
57	R:R:P113	R:R:V112	3.53	No	No	0	9	7
58	R:R:V112	R:R:W364	3.68	No	Yes	0	7	7
59	R:R:F114	R:R:W134	7.02	No	Yes	0	5	5
60	R:R:G115	R:R:I118	3.53	No	No	0	6	6
61	R:R:G115	R:R:W134	4.22	No	Yes	0	6	5
62	R:R:T117	R:R:Y126	6.24	No	Yes	0	5	5
63	R:R:I118	R:R:W124	8.22	No	Yes	0	6	7
64	R:R:V119	R:R:W364	3.68	No	Yes	0	5	7
65	R:R:V120	R:R:W121	6.13	No	No	0	5	4
66	R:R:E125	R:R:W121	10.9	No	No	0	3	4
67	R:R:K214	R:R:R123	6.19	No	No	0	1	3
68	R:R:D217	R:R:R123	3.57	No	No	0	4	3
69	R:R:W124	R:R:Y126	15.43	Yes	Yes	0	7	5
70	R:R:C131	R:R:W124	7.84	No	Yes	6	9	7
71	R:R:W124	R:R:W134	10.31	Yes	Yes	0	7	5
72	R:R:C216	R:R:W124	11.75	No	Yes	6	9	7
73	R:R:E125	R:R:K214	8.1	No	No	0	3	1
74	R:R:F130	R:R:Y126	5.16	No	Yes	0	4	5
75	R:R:F129	R:R:F130	4.29	No	No	0	1	4
76	R:R:C131	R:R:C216	7.28	No	No	6	9	9
77	R:R:E132	R:R:H197	4.92	No	No	0	6	3
78	R:R:T135	R:R:W134	3.64	No	Yes	0	5	5
79	R:R:F218	R:R:T135	5.19	Yes	No	0	6	5
80	R:R:F191	R:R:S136	5.28	No	No	0	4	6
81	R:R:I194	R:R:S136	9.29	No	No	0	6	6
82	R:R:D138	R:R:Y367	11.49	No	Yes	1	7	8
83	R:R:S190	R:R:V139	4.85	No	No	0	7	7
84	R:R:L140	R:R:S190	7.51	Yes	No	0	6	7
85	R:R:F191	R:R:L140	3.65	No	Yes	0	4	6
86	R:R:V142	R:R:W337	9.81	No	Yes	0	6	8
87	R:R:E147	R:R:T143	4.23	No	No	0	6	7
88	R:R:S232	R:R:T143	7.99	No	No	0	7	7
89	R:R:A144	R:R:W183	7.78	No	Yes	0	8	9
90	R:R:F333	R:R:I146	10.05	Yes	No	1	9	8
91	R:R:I146	R:R:W337	8.22	No	Yes	1	8	8
92	R:R:E147	R:R:V182	7.13	No	No	0	6	6
93	R:R:E147	R:R:I185	5.47	No	No	0	6	5
94	R:R:F333	R:R:L149	3.65	Yes	Yes	1	9	8
95	R:R:L149	R:R:N373	6.87	Yes	No	1	8	9
96	R:R:L149	R:R:Y377	5.86	Yes	Yes	1	8	9
97	R:R:C150	R:R:I239	4.91	No	No	0	7	6
98	R:R:L178	R:R:V151	4.47	No	No	5	6	7
99	R:R:I152	R:R:Y377	8.46	No	Yes	0	9	9
100	R:R:A153	R:R:M240	4.83	No	Yes	1	9	8
101	R:R:A153	R:R:Y244	6.67	No	Yes	1	9	9
102	R:R:I239	R:R:L154	4.28	No	No	0	6	6
103	R:R:D155	R:R:Y166	5.75	No	No	0	9	8
104	R:R:R156	R:R:Y244	5.14	No	Yes	0	9	9
105	R:R:T161	R:R:Y157	16.23	No	No	3	6	8
106	R:R:V243	R:R:Y157	7.57	No	No	0	7	8
107	R:R:R246	R:R:Y157	12.35	No	No	3	5	8
108	R:R:L158	R:R:Y166	7.03	No	No	0	5	8
109	R:R:A159	R:R:Y166	9.34	No	No	0	8	8
110	R:R:E250	R:R:I160	5.47	No	No	0	6	9
111	R:R:R246	R:R:T161	5.17	No	No	3	5	6
112	R:R:E250	R:R:T161	9.88	No	No	3	6	6
113	R:R:R165	R:R:S162	3.95	No	No	0	6	6
114	R:R:L169	R:R:R165	14.58	No	No	0	5	6
115	R:R:L169	R:R:R174	3.64	No	No	0	5	7
116	R:R:R174	R:R:T171	5.17	No	No	0	7	8
117	R:R:R172	R:R:R176	8.53	No	No	0	3	4
118	R:R:S186	R:R:W183	4.94	No	Yes	0	8	9
119	R:R:L188	R:R:L192	4.15	No	No	0	4	7
120	R:R:P193	R:R:W198	6.76	No	No	0	7	5
121	R:R:P193	R:R:Y224	9.74	No	Yes	0	7	7
122	R:R:I194	R:R:W199	4.7	No	Yes	1	6	6
123	R:R:I194	R:R:Y224	3.63	No	Yes	1	6	7
124	R:R:M196	R:R:W198	9.31	No	No	0	4	5
125	R:R:H197	R:R:W199	4.23	No	Yes	0	3	6
126	R:R:H197	R:R:R200	11.28	No	No	0	3	5
127	R:R:W199	R:R:Y210	7.72	Yes	Yes	1	6	4
128	R:R:F218	R:R:W199	4.01	Yes	Yes	1	6	6
129	R:R:T220	R:R:W199	4.85	No	Yes	1	5	6
130	R:R:W199	R:R:Y224	3.86	Yes	Yes	1	6	7
131	R:R:R200	R:R:Y210	7.2	No	Yes	0	5	4
132	R:R:D204	R:R:R207	9.53	No	No	0	2	3
133	R:R:D204	R:R:R208	5.96	No	No	0	2	1
134	R:R:E205	R:R:R351	6.98	No	No	0	2	4
135	R:R:A206	R:R:Y210	4	Yes	Yes	1	3	4
136	R:R:A206	R:R:V219	5.09	Yes	No	1	3	4
137	R:R:C209	R:R:C215	7.28	No	No	0	5	4
138	R:R:V219	R:R:Y210	3.79	No	Yes	1	4	4
139	R:R:D212	R:R:P213	4.83	No	No	0	3	3
140	R:R:C215	R:R:D217	6.22	No	No	0	4	4
141	R:R:F218	R:R:T220	11.67	Yes	No	1	6	5
142	R:R:F349	R:R:R222	7.48	No	No	0	5	3
143	R:R:S228	R:R:Y224	5.09	No	Yes	0	6	7
144	R:R:I226	R:R:V345	4.61	No	No	0	5	5
145	R:R:F349	R:R:I226	3.77	No	No	0	5	5
146	R:R:V230	R:R:Y234	7.57	No	Yes	0	4	5
147	R:R:F233	R:R:Y234	6.19	Yes	Yes	0	8	5
148	R:R:F233	R:R:L237	10.96	Yes	No	1	8	6
149	R:R:F233	R:R:F333	8.57	Yes	Yes	1	8	9
150	R:R:F233	R:R:L338	7.31	Yes	No	0	8	6
151	R:R:F233	R:R:F341	19.29	Yes	Yes	1	8	7
152	R:R:V345	R:R:Y234	5.05	No	Yes	0	5	5
153	R:R:P236	R:R:V235	3.53	No	No	0	9	6
154	R:R:F333	R:R:L237	3.65	Yes	No	1	9	6
155	R:R:M240	R:R:Y244	3.59	Yes	Yes	1	8	9
156	R:R:M240	R:R:M330	7.22	Yes	No	1	8	8
157	R:R:F333	R:R:M240	6.22	Yes	Yes	1	9	8
158	R:R:F242	R:R:V243	3.93	No	No	0	5	7
159	R:R:L326	R:R:Y244	3.52	No	Yes	0	8	9
160	R:R:I329	R:R:Y244	9.67	No	Yes	1	8	9
161	R:R:M330	R:R:Y244	3.59	No	Yes	1	8	9
162	R:R:L245	R:R:R249	8.5	No	No	0	2	4
163	R:R:E250	R:R:R246	8.14	No	No	3	6	5
164	R:R:F248	R:R:Q252	11.71	Yes	No	0	6	6
165	R:R:F248	R:R:L323	4.87	Yes	No	0	6	8
166	R:R:F248	R:R:L326	3.65	Yes	No	0	6	8
167	R:R:D259	R:R:S260	4.42	No	No	0	4	4
168	R:R:K321	R:R:L317	4.23	No	No	0	8	5
169	R:R:K324	R:R:L317	4.23	No	No	0	7	5
170	R:R:L323	R:R:Q320	6.65	No	No	0	8	5
171	R:R:K324	R:R:Q320	6.78	No	No	0	7	5
172	R:R:I328	W:W:?1	14.26	No	Yes	0	6	0
173	R:R:I329	R:R:I376	4.42	No	No	1	8	8
174	R:R:I329	R:R:Y377	3.63	No	Yes	1	8	9
175	R:R:N369	R:R:V332	4.43	No	No	0	9	6
176	R:R:F372	R:R:V332	3.93	No	No	0	6	6
177	R:R:F333	R:R:W337	4.01	Yes	Yes	1	9	8
178	R:R:C336	R:R:N369	7.87	No	No	0	8	9
179	R:R:F340	R:R:W337	7.02	Yes	Yes	1	7	8
180	R:R:F341	R:R:W337	9.02	Yes	Yes	1	7	8
181	R:R:G366	R:R:W337	11.26	No	Yes	0	7	8
182	R:R:N369	R:R:W337	6.78	No	Yes	0	9	8
183	R:R:F362	R:R:P339	10.11	No	No	0	5	9
184	R:R:F340	R:R:F341	8.57	Yes	Yes	1	7	7
185	R:R:F340	R:R:F359	7.5	Yes	No	0	7	5
186	R:R:F340	R:R:N363	8.46	Yes	No	1	7	6
187	R:R:F359	R:R:N344	3.62	No	No	0	5	6
188	R:R:K347	R:R:R351	4.95	Yes	No	0	4	4
189	R:R:K347	R:R:V354	4.55	Yes	Yes	0	4	5
190	R:R:F359	R:R:K347	4.96	No	Yes	0	5	4
191	R:R:E352	R:R:H350	9.85	No	No	8	5	4
192	R:R:H350	R:R:L353	3.86	No	No	8	4	3
193	R:R:E352	R:R:L353	3.98	No	No	8	5	3
194	R:R:P355	R:R:V354	3.53	No	Yes	0	5	5
195	R:R:R357	R:R:V360	7.85	No	No	0	1	5
196	R:R:F361	R:R:L358	3.65	No	No	7	4	5
197	R:R:F362	R:R:L358	6.09	No	No	7	5	5
198	R:R:F361	R:R:F362	6.43	No	No	7	4	5
199	R:R:F361	R:R:L365	3.65	No	No	0	4	7
200	R:R:N363	R:R:Y367	15.12	No	Yes	1	6	8
201	R:R:W364	R:R:Y367	6.75	Yes	Yes	0	7	8
202	R:R:I375	W:W:?1	12.23	No	Yes	0	6	0
203	R:R:I376	R:R:Y377	4.84	No	Yes	1	8	9
204	R:R:C378	R:R:F383	9.78	No	Yes	0	8	8
205	R:R:R379	W:W:?1	15.61	No	Yes	0	5	0
206	R:R:P381	R:R:S380	3.56	No	No	0	5	9
207	R:R:F383	R:R:S380	6.61	Yes	No	0	8	9
208	R:R:F383	R:R:F387	7.5	Yes	Yes	0	8	7
209	R:R:P87	R:R:T86	3.5	No	No	0	7	6
210	R:R:N221	R:R:Y224	3.49	No	Yes	0	5	7
211	R:R:F387	W:W:?1	3.48	Yes	Yes	0	7	0
212	R:R:L140	R:R:W183	3.42	Yes	Yes	0	6	9
213	R:R:I146	R:R:P236	3.39	No	No	0	8	9
214	R:R:L338	R:R:P339	3.28	No	No	0	6	9
215	R:R:L358	R:R:P355	3.28	No	No	0	5	5
216	R:R:A371	R:R:I72	3.25	No	No	0	6	8
217	R:R:A101	R:R:I80	3.25	No	No	0	9	7
218	R:R:A348	R:R:I226	3.25	No	No	0	5	5
219	R:R:S99	R:R:V179	3.23	No	No	0	9	7
220	R:R:S229	R:R:V345	3.23	No	No	0	7	5
221	R:R:V189	R:R:V231	3.21	No	No	0	6	4
222	R:R:V346	R:R:V354	3.21	No	Yes	0	5	5
223	R:R:A386	R:R:L89	3.15	No	Yes	0	7	8
224	R:R:C215	R:R:D212	3.11	No	No	0	4	3
225	R:R:I160	R:R:V247	3.07	No	No	0	9	9
226	R:R:M61	R:R:V120	3.04	No	No	0	4	5
227	R:R:L100	R:R:S145	3	No	No	0	9	9
228	R:R:L158	R:R:S162	3	No	No	0	5	6
229	R:R:L109	R:R:V73	2.98	No	No	0	5	5
230	R:R:L105	R:R:V77	2.98	No	No	0	7	3
231	R:R:L110	R:R:V106	2.98	No	No	0	6	7
232	R:R:L338	R:R:T334	2.95	No	No	0	6	6
233	R:R:I83	R:R:M98	2.92	Yes	No	0	7	6
234	R:R:W121	R:R:Y126	2.89	No	Yes	0	4	5
235	R:R:F164	R:R:P163	2.89	No	No	0	6	8
236	R:R:P381	R:R:R384	2.88	No	No	0	5	9
237	R:R:G127	R:R:W124	2.81	No	Yes	0	5	7
238	R:R:A82	R:R:F387	2.77	No	Yes	0	8	7
239	R:R:L158	R:R:L170	2.77	No	No	0	5	7
240	R:R:A322	R:R:F248	2.77	No	Yes	0	8	6
241	R:R:A368	R:R:F372	2.77	No	No	0	4	6
242	R:R:A103	R:R:W183	2.59	No	Yes	0	8	9
243	R:R:A116	R:R:W364	2.59	No	Yes	0	6	7
244	R:R:V360	R:R:W364	2.45	No	Yes	0	5	7
245	R:R:L342	R:R:Y234	2.34	No	Yes	0	5	5
246	R:R:C180	R:R:G177	1.96	No	No	0	3	2
247	R:R:A59	R:R:G62	1.95	No	No	0	4	5
248	R:R:A74	R:R:G75	1.95	No	No	0	3	8
249	R:R:C150	R:R:P236	1.88	No	No	0	7	9
250	R:R:A394	R:R:C392	1.81	No	No	0	4	4
251	R:R:A201	R:R:A206	1.79	No	Yes	0	4	3
252	R:R:A225	R:R:A348	1.79	No	No	0	6	5
253	R:R:A251	R:R:A322	1.79	No	No	0	9	8
254	R:R:P163	R:R:S162	1.78	No	No	0	8	6
255	R:R:G75	R:R:L78	1.71	No	No	0	8	7
256	R:R:G108	R:R:L109	1.71	No	No	0	7	5
257	R:R:A206	R:R:S203	1.71	Yes	No	0	3	2
258	R:R:A101	R:R:V79	1.7	No	No	0	9	9
259	R:R:A153	R:R:V243	1.7	No	No	0	9	7
260	R:R:A343	R:R:V354	1.7	No	Yes	0	4	5
261	R:R:L192	R:R:P193	1.64	No	No	0	7	7
262	R:R:G389	R:R:Q388	1.64	No	No	0	5	5
263	R:R:G331	W:W:?1	1.63	No	Yes	0	6	0
264	R:R:V77	R:R:V81	1.6	No	No	0	3	4
265	R:R:C393	R:R:L391	1.59	No	No	0	8	6
266	R:R:A371	R:R:L71	1.58	No	No	0	6	4
267	R:R:P87	R:R:Q90	1.58	No	No	0	7	8
268	R:R:A175	R:R:L92	1.58	No	No	4	7	6
269	R:R:A175	R:R:L95	1.58	No	No	0	7	5
270	R:R:A187	R:R:L140	1.58	No	Yes	0	4	6
271	R:R:A175	R:R:L170	1.58	No	No	4	7	7
272	R:R:A223	R:R:N221	1.56	No	No	0	3	5
273	R:R:I185	R:R:V189	1.54	No	No	0	5	6
274	R:R:G122	R:R:R123	1.5	No	No	0	4	3
275	R:R:G177	R:R:R176	1.5	No	No	0	2	4
276	R:R:L70	R:R:V73	1.49	No	No	0	4	5
277	R:R:L64	R:R:M65	1.41	No	No	0	4	6
278	R:R:L63	R:R:L64	1.38	No	No	0	4	4
279	R:R:A173	R:R:R176	1.38	No	No	0	5	4
280	R:R:D259	R:R:K257	1.38	No	No	0	4	5
281	R:R:D356	R:R:K347	1.38	No	Yes	0	2	4
282	R:R:E202	R:R:N221	1.31	No	No	0	2	5
283	R:R:F191	R:R:L133	1.22	No	No	0	4	4
284	R:R:F248	R:R:L245	1.22	Yes	No	0	6	2
285	R:R:D212	R:R:R208	1.19	No	No	0	3	1
286	R:R:F164	R:R:Q167	1.17	No	No	0	6	6
287	R:R:F349	R:R:H350	1.13	No	No	0	5	4
288	R:R:T325	W:W:?1	0.7	No	Yes	0	9	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.791	10	1	0
2	R:R:I83	4.8725	4	2	7
3	R:R:L89	6.032	5	2	8
4	R:R:N94	6.0425	4	2	9
5	R:R:F96	5.9325	4	5	8
6	R:R:W124	9.39333	6	6	7
7	R:R:Y126	7.43	4	0	5
8	R:R:W134	7	5	0	5
9	R:R:L140	4.04	4	0	6
10	R:R:L149	5.48	4	1	8
11	R:R:W183	4.982	5	0	9
12	R:R:W199	4.895	6	1	6
13	R:R:A206	3.1475	4	1	3
14	R:R:Y210	5.6775	4	1	4
15	R:R:F218	6.365	4	1	6
16	R:R:Y224	5.162	5	1	7
17	R:R:F233	10.464	5	1	8
18	R:R:Y234	5.2875	4	0	5
19	R:R:M240	5.465	4	1	8
20	R:R:Y244	5.36333	6	1	9
21	R:R:F248	4.844	5	0	6
22	R:R:F333	6.025	6	1	9
23	R:R:W337	8.01714	7	1	8
24	R:R:F340	9.292	5	1	7
25	R:R:F341	11.8	4	1	7
26	R:R:K347	3.96	4	0	4
27	R:R:V354	3.2475	4	0	5
28	R:R:W364	5.23286	7	0	7
29	R:R:Y367	8.4	5	1	8
30	R:R:Y377	5.284	5	1	9
31	R:R:F383	7.23833	6	2	8
32	R:R:F387	5.8725	4	0	7
33	W:W:?1	7.985	6	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D138	47.2786	21.72	Yes	No	1	0	7
2	R:R:W364	R:R:Y367	21.1509	6.75	Yes	Yes	0	7	8
3	R:R:N363	R:R:Y367	31.3602	15.12	No	Yes	1	6	8
4	R:R:M107	R:R:Y367	11.7857	3.59	No	Yes	0	7	8
5	R:R:V112	R:R:W364	10.2679	3.68	No	Yes	0	7	7
6	L:L:?1	R:R:V142	30.09	9.82	Yes	No	0	0	6
7	R:R:V142	R:R:W337	29.9116	9.81	No	Yes	0	6	8
8	R:R:F333	R:R:W337	100	4.01	Yes	Yes	1	9	8
9	R:R:F333	R:R:L149	90.2594	3.65	Yes	Yes	1	9	8
10	R:R:L149	R:R:Y377	84.987	5.86	Yes	Yes	1	8	9
11	R:R:I97	R:R:Y377	65.4844	3.63	No	Yes	0	8	9
12	R:R:I97	R:R:N94	63.9852	5.66	No	Yes	0	8	9
13	R:R:F383	R:R:N94	46.4398	8.46	Yes	Yes	2	8	9
14	R:R:F383	R:R:F387	21.3293	7.5	Yes	Yes	0	8	7
15	L:L:?1	R:R:F340	32.7209	14.91	Yes	Yes	1	0	7
16	R:R:F340	R:R:W337	52.2687	7.02	Yes	Yes	1	7	8
17	L:L:?1	R:R:F341	66.4829	10.32	Yes	Yes	1	0	7
18	R:R:F341	R:R:W337	30.2391	9.02	Yes	Yes	1	7	8
19	R:R:F233	R:R:F341	39.8253	19.29	Yes	Yes	1	8	7
20	R:R:F233	R:R:F333	32.4892	8.57	Yes	Yes	1	8	9
21	R:R:I83	R:R:N94	14.5204	5.66	Yes	Yes	2	7	9
22	R:R:I83	R:R:L89	11.3304	7.14	Yes	Yes	2	7	8
23	R:R:F383	R:R:L89	11.7031	7.31	Yes	Yes	2	8	8
24	L:L:?1	R:R:V139	22.232	5.61	Yes	No	0	0	7
25	R:R:S190	R:R:V139	20.7168	4.85	No	No	0	7	7
26	R:R:L140	R:R:S190	19.231	7.51	Yes	No	0	6	7
27	R:R:L140	R:R:W183	15.0636	3.42	Yes	Yes	0	6	9
28	R:R:I152	R:R:Y377	25.3022	8.46	No	Yes	0	9	9
29	R:R:F96	R:R:I152	23.7471	3.77	Yes	No	0	8	9
30	R:R:D155	R:R:F96	19.2789	4.78	No	Yes	0	9	8
31	R:R:D138	R:R:V111	38.5445	10.22	No	No	1	7	7
32	L:L:?1	R:R:F218	57.6104	4.59	Yes	Yes	1	0	6
33	R:R:F218	R:R:T135	40.1662	5.19	Yes	No	0	6	5
34	R:R:T135	R:R:W134	39.0717	3.64	No	Yes	0	5	5
35	R:R:V111	R:R:W134	49.0787	9.81	No	Yes	0	7	5
36	R:R:W124	R:R:W134	75.6963	10.31	Yes	Yes	0	7	5
37	R:R:W124	R:R:Y126	60.2546	15.43	Yes	Yes	0	7	5
38	R:R:W121	R:R:Y126	47.7286	2.89	No	Yes	0	4	5
39	R:R:E125	R:R:W121	38.2782	10.9	No	No	0	3	4
40	R:R:E125	R:R:K214	35.1174	8.1	No	No	0	3	1
41	R:R:K214	R:R:R123	31.9513	6.19	No	No	0	1	3
42	R:R:D217	R:R:R123	25.6031	3.57	No	No	0	4	3
43	R:R:F218	R:R:W199	18.1632	4.01	Yes	Yes	1	6	6
44	L:L:?1	R:R:S228	16.6747	8.48	Yes	No	0	0	6
45	R:R:S228	R:R:Y224	15.0477	5.09	No	Yes	0	6	7
46	L:L:?1	R:R:S232	12.1878	5.65	Yes	No	0	0	7
47	R:R:S232	R:R:T143	10.4623	7.99	No	No	0	7	7
48	R:R:F333	R:R:M240	42.4056	6.22	Yes	Yes	1	9	8
49	R:R:A153	R:R:M240	17.5933	4.83	No	Yes	1	9	8
50	R:R:M240	R:R:Y244	21.971	3.59	Yes	Yes	1	8	9
51	R:R:D155	R:R:Y166	16.3578	5.75	No	No	0	9	8
52	R:R:A153	R:R:V243	18.4774	1.7	No	No	0	9	7
53	R:R:V243	R:R:Y157	15.1489	7.57	No	No	0	7	8
54	R:R:L158	R:R:Y166	13.4926	7.03	No	No	0	5	8
55	R:R:L158	R:R:S162	12.6804	3	No	No	0	5	6
56	R:R:C215	R:R:D217	22.421	6.22	No	No	0	4	4
57	R:R:C215	R:R:D212	16.0409	3.11	No	No	0	4	3
58	R:R:F233	R:R:Y234	12.6405	6.19	Yes	Yes	0	8	5
59	R:R:L326	R:R:Y244	20.171	3.52	No	Yes	0	8	9
60	R:R:F248	R:R:L326	18.4987	3.65	Yes	No	0	6	8
61	R:R:F340	R:R:N363	24.0161	8.46	Yes	No	1	7	6
62	R:R:V111	R:R:Y367	12.2171	5.05	No	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D138	21.72	1	Yes	No	0	7	0	1
L:L:?1	R:R:V139	5.61	1	Yes	No	0	7	0	1
L:L:?1	R:R:V142	9.82	1	Yes	No	0	6	0	1
L:L:?1	R:R:F218	4.59	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S228	8.48	1	Yes	No	0	6	0	1
L:L:?1	R:R:S232	5.65	1	Yes	No	0	7	0	1
L:L:?1	R:R:F340	14.91	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F341	10.32	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N344	3.88	1	Yes	No	0	6	0	1
L:L:?1	R:R:N363	12.93	1	Yes	No	0	6	0	1
R:R:D138	R:R:V111	10.22	1	No	No	7	7	1	2
R:R:V111	R:R:Y367	5.05	1	No	Yes	7	8	2	2
R:R:F218	R:R:T135	5.19	1	Yes	No	6	5	1	2
R:R:D138	R:R:Y367	11.49	1	No	Yes	7	8	1	2
R:R:S190	R:R:V139	4.85	0	No	No	7	7	2	1
R:R:V142	R:R:W337	9.81	0	No	Yes	6	8	1	2
R:R:S232	R:R:T143	7.99	0	No	No	7	7	1	2
R:R:F218	R:R:W199	4.01	1	Yes	Yes	6	6	1	2
R:R:T220	R:R:W199	4.85	1	No	Yes	5	6	2	2
R:R:W199	R:R:Y224	3.86	1	Yes	Yes	6	7	2	2
R:R:F218	R:R:T220	11.67	1	Yes	No	6	5	1	2
R:R:S228	R:R:Y224	5.09	0	No	Yes	6	7	1	2
R:R:F233	R:R:F341	19.29	1	Yes	Yes	8	7	2	1
R:R:F340	R:R:W337	7.02	1	Yes	Yes	7	8	1	2
R:R:F341	R:R:W337	9.02	1	Yes	Yes	7	8	1	2
R:R:F340	R:R:F341	8.57	1	Yes	Yes	7	7	1	1
R:R:F340	R:R:F359	7.5	1	Yes	No	7	5	1	2
R:R:F340	R:R:N363	8.46	1	Yes	No	7	6	1	1
R:R:F359	R:R:N344	3.62	0	No	No	5	6	2	1
R:R:N363	R:R:Y367	15.12	1	No	Yes	6	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F387	R:R:L78	9.74	0	Yes	No	7	7	1	2
R:R:I328	W:W:?1	14.26	0	No	Yes	6	0	1	0
R:R:I375	W:W:?1	12.23	0	No	Yes	6	0	1	0
R:R:R379	W:W:?1	15.61	0	No	Yes	5	0	1	0
R:R:F383	R:R:F387	7.5	2	Yes	Yes	8	7	2	1
R:R:F387	W:W:?1	3.48	0	Yes	Yes	7	0	1	0
R:R:A82	R:R:F387	2.77	0	No	Yes	8	7	2	1
R:R:G331	W:W:?1	1.63	0	No	Yes	6	0	1	0
R:R:T325	W:W:?1	0.7	0	No	Yes	9	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9L84_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	259
Number of Links	288
Number of Hubs	33
Number of Links mediated by Hubs	135
Number of Communities	8
Number of Nodes involved in Communities	53
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	80064
Length Of Smallest Path	3
Average Path Length	13.6411
Length of Longest Path	31
Minimum Path Strength	1.165
Average Path Strength	6.97581
Maximum Path Strength	18.315
Minimum Path Correlation	0.7
Average Path Correlation	0.934498
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	53.9021
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.3957
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein binding • binding • PDZ domain binding • protein domain specific binding • protein heterodimerization activity • protein dimerization activity • beta1-adrenergic receptor activity • adrenergic receptor binding • signaling receptor binding • G protein-coupled receptor binding • alpha-2A adrenergic receptor binding • multicellular organismal process • response to nutrient levels • multicellular organismal-level homeostasis • response to stimulus • homeostatic process • response to dietary excess • diet induced thermogenesis • temperature homeostasis • energy homeostasis • adaptive thermogenesis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus
Gene Ontology	Biological Process	• multicellular organismal process • response to nutrient levels • multicellular organismal-level homeostasis • response to stimulus • homeostatic process • response to dietary excess • diet induced thermogenesis • temperature homeostasis • energy homeostasis • adaptive thermogenesis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • heart process • system process • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of heart contraction • regulation of system process • positive regulation of biological process • positive regulation of blood pressure • positive regulation of blood circulation • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • circulatory system process • positive regulation of blood pressure by epinephrine-norepinephrine • regulation of multicellular organismal process • regulation of biological quality • blood circulation • regulation of heart rate • regulation of biological process • regulation of blood pressure • biological regulation • positive regulation of heart rate • positive regulation of heart rate by epinephrine-norepinephrine • positive regulation of heart contraction • regulation of blood circulation • regulation of systemic arterial blood pressure • positive regulation of multicellular organismal process • heart contraction • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • behavior • circadian behavior • sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • fear response • multicellular organismal response to stress • positive regulation of cardiac muscle cell apoptotic process • regulation of cellular process • positive regulation of programmed cell death • muscle cell apoptotic process • positive regulation of striated muscle cell apoptotic process • regulation of apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • cardiac muscle cell apoptotic process • positive regulation of muscle cell apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • cellular process • apoptotic process • programmed cell death • positive regulation of cellular process • developmental process • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • regulation of developmental process • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of cold-induced thermogenesis • cold-induced thermogenesis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • regulation of the force of heart contraction by chemical signal • regulation of the force of heart contraction • positive regulation of the force of heart contraction by chemical signal • positive regulation of the force of heart contraction by epinephrine-norepinephrine • regulation of tube diameter • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • heat generation • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • cell periphery • plasma membrane • membrane • early endosome • endosome • Schaffer collateral - CA1 synapse • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • cell body • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • insulin-like growth factor receptor binding • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ALE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ALE
Name	Epinephrine
Synonyms	Epinephrine acetate
Identifier
Formula	C9 H13 N O3
Molecular Weight	183.204
SMILES
PubChem	139148732
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


Code	DR7
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	DR7
Name	Atazanavir
Synonyms	ATAZANAVIR; METHYL [(1S,4S,5S,10S)-4-BENZYL-1,10-DI-TERT-BUTYL-5-HYDROXY-2,9,12-TRIOXO-7-(4-PYRIDIN-2-YLBENZYL)-13-OXA-3,7,8,11-TETRAAZATETRADEC-1-YL]CARBAMATE
Identifier
Formula	C38 H52 N6 O7
Molecular Weight	704.855
SMILES
PubChem	148192
Formal Charge	0
Total Atoms	103
Total Chiral Atoms	4
Total Bonds	105
Total Aromatic Bonds	19


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08588
Sequence	>9L84_nogp_Chain_R A G M G L L M A L I V L L I V A G N V L V I V A I A K T P R L Q T L T N L F I M S L A S A D L V M G L L V V P F G A T I V V W G R W E Y G S F F C E L W T S V D V L C V T A S I E T L C V I A L D R Y L A I T S P F R Y Q S L L T R A R A R G L V C T V W A I S A L V S F L P I L M H W W R A E S D E A R R C Y N D P K C C D F V T N R A Y A I A S S V V S F Y V P L C I M A F V Y L R V F R E A Q K Q V K K I D S L R E Q K A L K T L G I I M G V F T L C W L P F F L A N V V K A F H R E L V P D R L F V F F N W L G Y A N S A F N P I I Y C R S P D F R K A F Q G L L C C A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	2VT4	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.7	2008-06-24	doi.org/10.1038/nature07101
	2Y00	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.5	2011-01-12	doi.org/10.1038/nature09746
	2Y02	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carmoterol	-	-	2.6	2011-01-12	doi.org/10.1038/nature09746
	2Y03	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.85	2011-01-12	doi.org/10.1038/nature09746
	2Y04	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	3.05	2011-01-12	doi.org/10.1038/nature09746
	2Y01	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.6	2011-03-30	doi.org/10.1038/nature09746
	2YCW	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carazolol	-	-	3	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCX	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.25	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCZ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Iodocyanopindolol	-	-	3.65	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCY	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.15	2011-06-08	doi.org/10.1073/pnas.1100185108
	4AMI	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Bucindolol	-	-	3.2	2012-05-23	doi.org/10.1016/j.str.2012.03.014
	4AMJ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carvedilol	-	-	2.3	2012-05-23	doi.org/10.1016/j.str.2012.03.014
	4GPO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	-	-	-	3.5	2013-02-27	doi.org/10.1038/nsmb.2504
	3ZPQ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	PubChem 594590	Na	-	2.8	2013-04-03	doi.org/10.1021/jm400140q
	3ZPR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	PubChem 598754	Na	-	2.7	2013-04-03	doi.org/10.1021/jm400140q
	4BVN	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	Na	-	2.1	2014-04-02	doi.org/10.1371/journal.pone.0092727
	5A8E	A	Amine	Adrenergic	β₁	Meleagris gallopavo	7-Methylcyanopindolol	Na	-	2.4	2015-09-30	doi.org/10.1124/mol.115.101030
	5F8U	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.35	2015-12-23	doi.org/10.1038/nsmb.3130
	6H7J	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.8	2018-10-17	doi.org/10.1126/science.aau5595
	6H7L	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.7	2018-10-17	doi.org/10.1126/science.aau5595
	6H7M	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	2.76	2018-10-17	doi.org/10.1126/science.aau5595
	6H7N	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Xamoterol	-	-	2.5	2018-10-17	doi.org/10.1101/436212
	6H7O	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.8	2018-10-17	doi.org/10.1126/science.aau5595
	6IBL	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	-	2.7	2019-01-09	doi.org/10.1038/s41586-020-2419-1
	6TKO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	Arrestin2	3.3	2020-06-17	doi.org/10.1038/s41586-020-2419-1
	7JJO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gs/β1/γ2	2.6	2020-09-02	doi.org/10.1016/j.molcel.2020.08.001
	7JJO (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.6	2020-09-02	doi.org/10.1016/j.molcel.2020.08.001
	7BTS	A	Amine	Adrenergic	β₁	Homo sapiens	Epinephrine	-	-	3.13	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BU6	A	Amine	Adrenergic	β₁	Homo sapiens	Norepinephrine	-	-	2.7	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BU7	A	Amine	Adrenergic	β₁	Homo sapiens	BI167107	-	-	2.6	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BVQ	A	Amine	Adrenergic	β₁	Homo sapiens	Carazolol	-	-	2.5	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7S0F	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gi1/β1/γ2	2.96	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0F (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.96	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0G	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	chim(Gi1-CtGs)/β1/γ2	3.86	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0G (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		3.86	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	8DCR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	Gs/β1/γ2	2.6	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCR (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-		2.6	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCS	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	Gs/β1/γ2	2.5	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCS (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-		2.5	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8S2T	A	Amine	Adrenergic	β₁	Homo sapiens	Isoprenaline	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-05-21	To be published
	8S2T (No Gprot)	A	Amine	Adrenergic	β₁	Homo sapiens	Isoprenaline	-		3.3	2025-05-21	To be published
	9L84	A	Amine	Adrenergic	β₁	Homo sapiens	Epinephrine	Atazanavir	Gs/β1/γ2	3.22	2025-12-31	To be published
	9L84 (No Gprot)	A	Amine	Adrenergic	β₁	Homo sapiens	Epinephrine	Atazanavir		3.22	2025-12-31	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9L84_nogp.zip

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